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- Forteza, MJ, et al.
(författare)
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Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients
- 2018
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Ingår i: Oxidative medicine and cellular longevity. - : Hindawi Limited. - 1942-0994 .- 1942-0900. ; 2018, s. 1975167-
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Tidskriftsartikel (refereegranskat)abstract
- ST-segment elevation myocardial infarction (STEMI) is the most severe outcome of coronary artery disease. Despite rapid reperfusion of the artery, acute irrigation of the cardiac tissue is associated with increased inflammation. While innate immune response in STEMI is well described, an in-depth characterization of adaptive immune cell dynamics and their potential role remains elusive. We performed a translational study using a controlled porcine reperfusion model of STEMI and the analysis of lymphocyte subsets in 116 STEMI patients undergoing percutaneous coronary intervention (PCI). In the animal model, a sharp drop in circulating T lymphocytes occurred within the first hours after reperfusion. Notably, increased apoptosis of circulating lymphocytes and infiltration of proinflammatory Th1 lymphocytes in the heart were observed 48 h after reperfusion. Similarly, in STEMI patients, a sharp drop in circulating T lymphocyte subsets occurred within the first 24 h post-PCI. A cardiac magnetic resonance (CMR) evaluation of these patients revealed an inverse association between 24 h circulating T lymphocyte numbers and infarction size at 1-week and 6-month post-PCI. Our translational approach revealed striking changes in the circulating and tissue-infiltrating T lymphocyte repertoire in response to ischemia-reperfusion. These findings may help in developing new diagnostic and therapeutic approaches for coronary diseases.
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- Harper, David A.T., et al.
(författare)
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The Furongian (late Cambrian) Biodiversity Gap : Real or apparent?
- 2019
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Ingår i: Palaeoworld. - Amsterdam : Elsevier BV. - 1871-174X .- 1875-5887. ; 28:1-2, s. 4-12
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Tidskriftsartikel (refereegranskat)abstract
- Two major, extended diversifications punctuated the evolution of marine life during the Early Palaeozoic. The interregnum, however, between the Cambrian Explosion and the Great Ordovician Biodiversification Event, is exemplified by the Furongian Gap when there was a marked drop in biodiversity. It is unclear whether the gap is apparent, due to sampling failure or lack of rock, or real — associated with unique and fluctuating environments, a distinctive palaeogeography and extreme climates during the late Cambrian. Indications suggest that there has been little attention paid to this interval compared with those below and above, while some of the classical areas for Cambrian research, such as Bohemia, have poor coverage through the Furongian. Moreover, based on information available in databases and the literature, together with the ghost ranges of many higher taxa through the Furongian, data suggest that biodiversity in this stage has been significantly underestimated. Emphasis, to date, has been placed on widespread, deeper-water dark shale facies of the interval, with generally low diversity faunas, whereas shallow-water communities have often been neglected.
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