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- Purans, J., et al.
(författare)
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Local electronic structure rearrangements and strong anharmonicity in YH3 under pressures up to 180 GPa
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- The discovery of superconductivity above 250 K at high pressure in LaH10 and the prediction of overcoming the room temperature threshold for superconductivity in YH10 urge for a better understanding of hydrogen interaction mechanisms with the heavy atom sublattice in metal hydrides under high pressure at the atomic scale. Here we use locally sensitive X-ray absorption fine structure spectroscopy (XAFS) to get insight into the nature of phase transitions and the rearrangements of local electronic and crystal structure in archetypal metal hydride YH3 under pressure up to 180 GPa. The combination of the experimental methods allowed us to implement a multiscale length study of YH3: XAFS (short-range), Raman scattering (medium-range) and XRD (long-range). XANES data evidence a strong effect of hydrogen on the density of 4d yttrium states that increases with pressure and EXAFS data evidence a strong anharmonicity, manifested as yttrium atom vibrations in a double-well potential.
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| 4. |
- Gadner, H, et al.
(författare)
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Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification
- 2008
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 111:5, s. 2556-2562
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Tidskriftsartikel (refereegranskat)abstract
- Multisystem Langerhans cell histiocytosis (MS-LCH) is associated with high mortality when patients have risk organ involvement (RO+) or are younger than 2 years. In an international randomized trial, LCH-II, we intensified their treatment: arm A consisted of 6 weeks of daily prednisone and weekly vinblastine followed by 18 weeks of daily 6-mercaptopurine with vinblastine/prednisone pulses; etoposide was added in arm B. Considering all 193 randomized risk patients, there were similar outcomes: rapid (6 weeks) response (arm A vs arm B: 63%/71%), 5-year survival probability (74%/79%), disease reactivation frequency (46%/46%), and permanent consequences (43%/37%). However, (1) patients younger than 2 years without RO involvement (RO−) had 100% survival and uniformly high (> 80%) rapid response, (2) RO+ patients not responding within 6 weeks had highest mortality, and (3) importantly, the more intensive arm B reduced mortality in RO+ patients (relative hazard rate, accounting for differences in risk organ involvement, of 0.54; 95% CI = 0.29-1.00). Finally, comparison of RO+ patients in LCH-I and LCH-II confirmed that increasing treatment intensity increased rapid responses (from 43% in arm A LCH-I to 68% in arm B LCH-II; P = .027) and reduced mortality (from 44% in arm A LCH-I to 27% in arm B LCH-II; P = .042). We conclude that intensified treatment significantly increases rapid response and reduces mortality in risk MS-LCH. This trial was registered at http://www.controlled-trials.com as no. ISRCTN57679341.
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- Sorensen, S. L., et al.
(författare)
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Electronic Doppler effect in resonant Auger decay of CO molecules upon excitation near a shake-up Pi resonance
- 2007
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : APS. - 1050-2947 .- 1094-1622. ; 76:062704
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Tidskriftsartikel (refereegranskat)abstract
- Wepresent an experimental observation of the electronic Doppler effect inresonant Auger spectra upon core excitation slightly above the carbonK edge of the CO molecule. Thus the electronic Dopplereffect has been identified in above-threshold excitation, and in atransition of symmetry. Ab initio calculations of the potentialenergy curves of the relevant states of CO and thewave packet technique have been employed to provide a theoreticalbackground to the experimental studies. The weak feature around 299.4 eVin the photoabsorption spectrum, whose decay has been investigated bythe present experiment, is assigned to double (core-valence) excitations toC 1s shake-up states |1s1−1*2 with a strong dissociative character,and the Doppler splitting of the atomic peak has beenreproduced by the simulation.
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