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| 8. |
- Bitar, C., et al.
(författare)
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11-Year outcomes in patients with metal-on-metal ASR hip arthroplasty
- 2022
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Ingår i: Journal of Orthopaedics. - : Elsevier BV. - 0972-978X .- 2589-9082. ; 32, s. 98-103
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Tidskriftsartikel (refereegranskat)abstract
- Background: We analysed the long-term revision rate, clinical outcomes and metal ion concentrations in blood over time in patients who had undergone metal-on metal Articular Surface Replacement (ASR) hip arthroplasty. Methods: A total of 38 patients (43 hips) were included: 24 patients (28 hips) underwent large-head total hip arthroplasty (XL THA), and 14 patients (15 hips) underwent hip resurfacing arthroplasty (HRA). The median follow-up time was 11 (range 7-12) years. Results: None of 15 HRA implants were revised. Nine of 28 XL THA implants (32%) in 8 patients were revised. The Co ion levels significantly increased in the XL THA group (p=0.009) over a median time period of 84 (25-97) months. Conclusion: The levels of Co ions in blood were higher in the patients who had undergone XL THA and increased significantly over time.
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| 9. |
- Brugnara, Y., et al.
(författare)
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A collection of sub-daily pressure and temperature observations for the early instrumental period with a focus on the "year without a summer" 1816
- 2015
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Ingår i: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 11:8, s. 1027-1047
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Tidskriftsartikel (refereegranskat)abstract
- The eruption of Mount Tambora (Indonesia) in April 1815 is the largest documented volcanic eruption in history. It is associated with a large global cooling during the following year, felt particularly in parts of Europe and North America, where the year 1816 became known as the "year without a summer". This paper describes an effort made to collect surface meteorological observations from the early instrumental period, with a focus on the years of and immediately following the eruption (1815–1817). Although the collection aimed in particular at pressure observations, correspondent temperature observations were also recovered. Some of the series had already been described in the literature, but a large part of the data, recently digitised from original weather diaries and contemporary magazines and newspapers, is presented here for the first time. The collection puts together more than 50 sub-daily series from land observatories in Europe and North America and from ships in the tropics. The pressure observations have been corrected for temperature and gravity and reduced to mean sea level. Moreover, an additional statistical correction was applied to take into account common error sources in mercury barometers. To assess the reliability of the corrected data set, the variance in the pressure observations is compared with modern climatologies, and single observations are used for synoptic analyses of three case studies in Europe. All raw observations will be made available to the scientific community in the International Surface Pressure Databank.
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| 11. |
- Gamfeldt, Lars, 1975, et al.
(författare)
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Higher levels of multiple ecosystem services are found in forests with more tree species
- 2013
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000km2, we report that tree species richness in production forests shows positive to positively hump-shaped relationships with multiple ecosystem services. These include production of tree biomass, soil carbon storage, berry production and game production potential. For example, biomass production was approximately 50% greater with five than with one tree species. In addition, we show positive relationships between tree species richness and proxies for other biodiversity components. Importantly, no single tree species was able to promote all services, and some services were negatively correlated to each other. Management of production forests will therefore benefit from considering multiple tree species to sustain the full range of benefits that the society obtains from forests.
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| 12. |
- Jungclaus, Johann H., et al.
(författare)
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The PMIP4 contribution to CMIP6 - Part 3 : The last millennium, scientific objective, and experimental design for the PMIP4 past1000 simulations
- 2017
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Ingår i: Geoscientific Model Development. - : Copernicus GmbH. - 1991-959X .- 1991-9603. ; 10:11, s. 4005-4033
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Tidskriftsartikel (refereegranskat)abstract
- The pre-industrial millennium is among the periods selected by the Paleoclimate Model Intercomparison Project (PMIP) for experiments contributing to the sixth phase of the Coupled Model Intercomparison Project (CMIP6) and the fourth phase of the PMIP (PMIP4). The past1000 transient simulations serve to investigate the response to (mainly) natural forcing under background conditions not too different from today, and to discriminate between forced and internally generated variability on interannual to centennial timescales. This paper describes the motivation and the experimental set-ups for the PMIP4-CMIP6 past1000 simulations, and discusses the forcing agents orbital, solar, volcanic, and land use/land cover changes, and variations in greenhouse gas concentrations. The past1000 simulations covering the pre-industrial millennium from 850 Common Era (CE) to 1849 CE have to be complemented by historical simulations (1850 to 2014 CE) following the CMIP6 protocol. The external forcings for the past1000 experiments have been adapted to provide a seamless transition across these time periods. Protocols for the past1000 simulations have been divided into three tiers. A default forcing data set has been defined for the Tier 1 (the CMIP6 past1000) experiment. However, the PMIP community has maintained the flexibility to conduct coordinated sensitivity experiments to explore uncertainty in forcing reconstructions as well as parameter uncertainty in dedicated Tier 2 simulations. Additional experiments (Tier 3) are defined to foster collaborative model experiments focusing on the early instrumental period and to extend the temporal range and the scope of the simulations. This paper outlines current and future research foci and common analyses for collaborative work between the PMIP and the observational communities (reconstructions, instrumental data).
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- Pettersson, Gunilla, et al.
(författare)
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Strong and bulky paperboard plies from low energy CTMP
- 2014
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Ingår i: International Mechanical Pulping Conference, IMPC 2014. - 9780000000002
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Konferensbidrag (refereegranskat)abstract
- A description is given regarding methods used to manufacture strong and bulky sheets from furnishes based on a broad range of surface modified CTMP qualities. Starch and CMC are adsorbed on the fibre surfaces using a multilayer or a MIX concept. It is shown that both the in-plane and out-of-plane strength for the CTMP based sheets after such surface treatment can be more than doubled at a maintained density. This can be utilized to improve bending stiffness or to reduce the basis weight in multi-ply paperboards.
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- Andersson, Helene, et al.
(författare)
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Consecutive microcontact printing - ligands for asymmetric catalysis in silicon channels
- 2001
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Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 79:1, s. 78-84
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Tidskriftsartikel (refereegranskat)abstract
- Consecutive microcontact printing ( mu CP) has been developed to enable multiple functionalization of silicon surfaces, such as the immobilization of chiral ligands. The technique involves two subsequent printing steps using unstructured poly(methylsiloxane) stamps. The pattern is already defined on the substrate, consisting of etched channels. Hence, no precise alignment is needed between the two printing steps. A carboxylic acid group containing reagent was initially printed onto the silicon oxide surface and transformed to an anhydride. hi the second printing step an ester bond was formed with the hydroxy-functionalized ligand. The formed molecular layers were evaluated by contact angle measurements, scanning electron microscopy (SEM) and electron spectroscopy for chemical analysis (ESCA), indicating that the consecutive mu CP was successful. Initially, printing was performed on planar silicon surfaces but to realize a flow-through microfluidic device for high throughput screening a mu CP technique was developed for etched channels. To verify the technique, hydrophobic valves consisting of octadecyltrichlorosilane were formed using mu CP in deep reactive ion etched channels (50 mum wide and 50 mum deep). The printed hydrophobic patches were visualized by SEM and functioned well. Finally, the consecutive mu CP technique was applied to immobilize the ligand in the channels. The channels were then sealed with a low-temperature bonding technique using an adhesive PDMS film, which does not destroy the printed ligand. In this study mu CP is used in a novel manner. It enables a convenient method for performing complex surface modification of etched structures, which is a frequently appearing problem in biochemical microfluidic systems.
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| 21. |
- Andersson, Helene, et al.
(författare)
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Patterned self-assembled beads in silicon channels
- 2001
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Ingår i: Electrophoresis. - 0173-0835 .- 1522-2683. ; 22:18, s. 3876-3882
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Tidskriftsartikel (refereegranskat)abstract
- A novel technique enabling selective bead trapping in microfluidic devices without the use of physical barriers is presented in this paper. It is a fast, convenient and simple method, involving microcontact printing and self-assembly, that can be applied to silicon, quartz or plastic substrates. In the first step, channels are etched in the substrate. The surface chemistry of the internal walls of the channels is then modified by microcontact printing. The chip is submerged in a bead slurry where beads self-assemble based on surface chemistry and immobilize on the internal walls of the channels. Silicon channels (100 mum wide and 50 mum deep) have been covered with monolayers of streptavidin-, amino- and hydroxy-functionalized microspheres and resulted in good surface coverage of beads on the channel walls. A high-resolution pattern of lines of self-assembled streptavidin beads, as narrow as 5 mum, has also been generated on the bottom of a 500 mum wide and 50 mum deep channel. Flow tests were performed in sealed channels with the different immobilized beads to confirm that the immobilized beads could withstand the forces generated by water flowing in the channels. The presented results indicate that single beads can be precisely positioned within microfluidic devices based on self-assembly which is useful as screening and analysis tools within the field of biochemistry and organic chemistry.
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| 22. |
- Andersson, Helene, et al.
(författare)
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Self-assembled and self-sorted array of chemically active beads for analytical and biochemical screening
- 2002
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Ingår i: Talanta. - 0039-9140 .- 1873-3573. ; 56:2, s. 301-308
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Tidskriftsartikel (refereegranskat)abstract
- A technique for generating a general screening platform consisting of dots of immobilized beads on silicon has been developed via self-sorting and -assembly of different kinds of beads. The dots are defined by a teflon-like film, which due to its hydrophobic characteristics also prevents cross-contamination of liquid from different dots. To enable functionalization of individual dots with different target molecules simultaneously a new way of microcontact printing has been explored where different target solutions are printed in parallel using one stamp. In order to show that this platform can be designed for both biochemical assays and organic chemistry, streptavidin-, amino- and hydroxy-functionalized beads have been self-sorted and -assembled both on separate and common platforms. The self-sorting and -arrangement are based on surface chemistry only, which has not previously been reported. Beads of different sizes and material have successfully been immobilized in line patterns as narrow as 5 mum. Besides silicon, quartz and polyethylene have also been used as substrates.
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| 23. |
- Arushanyan, Yevgeniya, et al.
(författare)
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A framework for sustainability assessment of ICT futures Scenarios and sustainability impacts of future ICT-societies
- 2015
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Ingår i: PROCEEDINGS OF ENVIROINFO AND ICT FOR SUSTAINABILITY 2015. - : Atlantis Press. - 9789462520929 ; , s. 1-9
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Konferensbidrag (refereegranskat)abstract
- The rapid development of information and communication technology (ICT) has an influence on all societal sectors and can have both positive and negative consequences. To support ICT for sustainability (ICT4S), we need to learn when and how ICT can enable sustainable development. It is important to take into account all types of potential impacts environmental and social, direct and indirect. Looking at future ICT societies and their potential environmental and social implications is of special interest, as this can provide valuable knowledge for planning and policy-making today to enable ICT4S. A methodological framework for environmental and social assessment of future ICT societies with a consumption perspective was developed as a part of a joint project with researchers at KTH, ICT industry, municipality and county. The overall goal of the project was to develop five different future scenarios for Swedish ICT societies and to assess the risks and opportunities for environmental and social consequences in those scenarios. This paper presents the framework for environmental and social assessment of future scenarios and discusses the challenges experienced and lessons learned in the process of the framework development. The framework is aimed to deal with a broad and complex object and scope of assessment, the inherent uncertainty and data restrictions of future scenarios, and is applying qualitative analysis.
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| 25. |
- Ballof, J., et al.
(författare)
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A concept for the extraction of the most refractory elements at CERN-ISOLDE as carbonyl complex ions
- 2022
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 58:5
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a novel thick-target concept tailored to the extraction of refractory 4d and 5d transition metal radionuclides of molybdenum, technetium, ruthenium and tungsten for radioactive ion beam production. Despite the more than 60-year old history of thick-target ISOL mass-separation facilities like ISOLDE, the extraction of these most refractory elements as radioactive ion beam has so far not been successful. In ordinary thick ISOL targets, their radioisotopes produced in the target are stopped within the condensed target material. Here, we present a concept which overcomes limitations associated with this method. We exploit the recoil momentum of nuclear reaction products for their release from the solid target material. They are thermalized in a carbon monoxide-containing atmosphere, in which volatile carbonyl complexes form readily at ambient temperature and pressure. This compound serves as volatile carrier for transport to the ion source. Excess carbon monoxide is removed by cryogenic gas separation to enable low pressures in the source region, in which the species are ionized and hence made available for radioactive ion beam formation. The setup is operated in batch mode. Initially, we investigate the feasibility of the approach with isotopes of more than 35s half-life. At the cost of reduced efficiency, the concept could also be applied to isotopes with half-lives of at least one to 10s. We report parameter studies of the key processes of the method, which validate this concept and which define the parameters for the setup. This would allow for the first time the extraction of radioactive molybdenum, tungsten and several other transition metals at thick-target ISOL facilities.
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| 26. |
- Beetz, Andrea, et al.
(författare)
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The Effect of a Real Dog, Toy Dog and Friendly Person on Insecurely Attached Children During a Stressful Task : An Exploratory Study
- 2011
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Ingår i: Anthrozoos. - : Taylor & Francis. - 0892-7936 .- 1753-0377. ; 24:4, s. 349-368
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Tidskriftsartikel (refereegranskat)abstract
- The regulation of stress by an attachment figure is a key feature of attachment relationships. Previous research suggests that in some cases animal companionship may be regarded as an attachment relationship. This may be particularly important for persons with an insecure or disorganized attachment pattern who may find it more difficult than securely attached individuals to accept social support from humans. In our study, we investigated whether 31 boys (aged 7-12 years) with insecure/disorganized attachment would profit more from the presence of a dog (n = 11) than of a friendly human (n = 11) or a toy dog (n = 9) as support during a socially stressful situation (Trier Social Stress Test for Children, TSST-C). Stress levels were assessed via salivary cortisol recorded five times before, during, and after the TSST-C. The behavior of the children was coded from video recordings. Self-reported stress levels did not significantly differ between the groups before and after the TSST-C. Salivary cortisol, however, was significantly lower in the real dog condition than in the other two conditions (Kruskal-Wallis H test on area under the curve increase (AUCi): chi(2) = 15.17, df = 2, p = 0.001). Also, the more the children stroked the dog, the less pronounced was their stress reaction (r(s) = -0.818, p = 0.002). Our data suggest an important role of physical contact in the stress reducing effect. We conclude that the children investigated profited more from interacting with a friendly dog than with either a human or a toy dog in a stressful situation. We discuss the relevance of our findings for animal-assisted interventions.
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| 29. |
- Bremberg, U, et al.
(författare)
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Rapid microwave-induced palladium-catalyzed asymmetric allylic alkylation
- 1999
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Ingår i: Journal of Organic Chemistry. - Royal Inst Technol, Dept Chem Organ Chem, S-10044 Stockholm, Sweden. Uppsala Univ, Uppsala Biomed Ctr, Dept Organ Pharmaceut Chem, S-75123 Uppsala, Sweden. : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 64, s. 1082-
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Tidskriftsartikel (refereegranskat)
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| 30. |
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| 31. |
- Byström, Jonas, et al.
(författare)
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Eosinophil cationic protein is stored in, but not produced by, peripheral blood neutrophils
- 2002
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 32:7, s. 1082-1091
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Eosinophil cationic protein (ECP) is an eosinophil-derived protein, which has been shown to be present in circulating neutrophils. OBJECTIVE: To establish whether ECP is produced or internalized by peripheral blood neutrophils. METHODS: This was done using microscopy, flow cytometry, fractionation of cells and RT-PCR techniques. RESULTS: No ECP mRNA was detected after extensive cell purification to eliminate all traces of contaminating eosinophils. Examination of immunostained neutrophils by light, confocal, electron microscopy together with cell fraction experiments, established that ECP is present intracellularly and is mostly associated to cell granules. Uptake studies by flow cytometry and by using both cold and radiolabelled ECP showed that it is internalized by neutrophils and stored in some proportion in their primary granules. Upon stimulation with serum-treated Sephadex particles, the internalized ECP was partially released from cells. CONCLUSION: ECP is not produced but can be internalized by circulating neutrophils, which take it from the environment and partially store it in their primary granules.
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| 32. |
- Cernerud, M, et al.
(författare)
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Chiral polymers via asymmetric epoxidation and asymmetric dihydroxylation
- 1996
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Ingår i: TETRAHEDRON-ASYMMETRY. - : PERGAMON-ELSEVIER SCIENCE LTD. ; 7:10
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Asymmetric epoxidation and dihydroxylation performed on suitably substituted styrene-divinylbenzene polymers yielded products which in some cases were difficult to analyze accurately, whereas asymmetric dihydroxylation of a p-hydroxycinnamic acid derivat
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| 33. |
- Coroama, Vlad C, et al.
(författare)
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Dematerialization Through Electronic Media?
- 2015
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Ingår i: ICT Innovations for Sustainability. - Cham : Springer. - 9783319092287 ; , s. 405-421
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- While the traditional roles of the computer as a machine for scientific calculations, text editing, and graphic design are still significant, computers are increasingly perceived as means of accessing information and interacting with other people – i.e., as electronic media. The aim of this chapter is to analyze digital electronic media and their effects on environmental sustainability. Two fields of application are addressed: electronic media that may replace or augment traditional print media such as newspapers or magazines, and videoconferencing as a potential substitute for traveling to a face-to-face meeting or conference. In both cases, the environmental costs of the electronic media are compared to those of their conventional counterparts. The examples show that electronic media can represent an energy-efficient alternative to traditional activities such as long-distance travel. But they can also be added on top of existing activities instead of replacing them. In such cases, a net increase in the environmental impact results. The availability of small, energy-efficient devices being used as electronic media does not guarantee dematerialization. The overall resource use and emissions throughout the life cycle of the media product systems and, more importantly, at the macro level of total global production and consumption need to be considered. To achieve the dematerialization potential of new electronic media solutions, their efficiency needs to be combined with sufficiency; thus additional measures are necessary to turn the dematerialization potential of electronic media into environmental relief.
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| 34. |
- Daly, D., et al.
(författare)
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How much synthetic oxytocin is infused during labour? A review and analysis of regimens used in 12 countries
- 2020
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:7
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Tidskriftsartikel (refereegranskat)abstract
- Objective To compare synthetic oxytocin infusion regimens used during labour, calculate the International Units (IU) escalation rate and total amount of IU infused over eight hours. Design Observational study Setting Twelve countries, eleven European and South Africa. Sample National, regional or institutional-level regimens on oxytocin for induction and augmentation labour Methods Data on oxytocin IU dose, infusion fluid amount, start dose, escalation rate and maximum dose were collected. Values for each regimen were converted to IU in 1000ml diluent. One IU corresponded to 1.67 mu g for doses provided in grams/micrograms. IU hourly dose increase rates were based on escalation frequency. Cumulative doses and total IU amount infused were calculated by adding the dose administered for each previous hour. Main Outcome Measures Oxytocin IU dose infused Results Data were obtained on 21 regimens used in 12 countries. Details on the start dose, escalation interval, escalation rate and maximum dose infused were available from 16 regimens. Starting rates varied from 0.06 IU/hour to 0.90 IU/hour, and the maximum dose rate varied from 0.90 IU/hour to 3.60 IU/hour. The total amount of IU oxytocin infused, estimated over eight hours, ranged from 2.38 IU to 27.00 IU, a variation of 24.62 IU and an 11-fold difference. Conclusion Current variations in oxytocin regimens for induction and augmentation of labour are inexplicable. It is crucial that the appropriate minimum infusion regimen is administered because synthetic oxytocin is a potentially harmful medication with serious consequences for women and babies when inappropriately used. Estimating the total amount of oxytocin IU received by labouring women, alongside the institution's mode of birth and neonatal outcomes, may deepen our understanding and be the way forward to identifying the optimal infusion regimen.
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| 39. |
- Hallberg, Ida, et al.
(författare)
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Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro
- 2022
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Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 109, s. 19-30
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Tidskriftsartikel (refereegranskat)abstract
- Knowledge on the effects of perfluorohexane sulfonate (PFHxS) on ovarian function is limited. In the current study, we investigated the sensitivity of oocytes to PFHxS during in vitro maturation (IVM), including conse-quences on embryo development at the morphological, transcriptomic, and epigenomic levels. Bovine cumulus-oocyte complexes (COCs) were exposed to PFHxS during 22 h IVM. Following fertilisation, developmental competence was recorded until day 8 of culture. Two experiments were conducted: 1) exposure of COCs to 0.01 mu g mL(-1) -100 mu g mL(-1) PFHxS followed by confocal imaging to detect neutral lipids and nuclei, and 2) exposure of COCs to 0.1 mu g mL(-1) PFHxS followed by analysis of transcriptomic and DNA methylation changes in blastocysts. Decreased oocyte developmental competence was observed upon exposure to & nbsp;>= 40 mu g mL(-1) PFHxS and altered lipid distribution was observed in the blastocysts upon exposure to 1-10 mu g mL(-1) PFHxS (not observed at lower or higher concentrations). Transcriptomic data showed that genes affected by 0.1 mu g mL(-1) PFHxS were enriched for pathways related to increased synthesis and production of reactive oxygen species. Enrichment for peroxisome proliferator-activated receptor-gamma and oestrogen pathways was also observed. Genes linked to DNA methylation changes were enriched for similar pathways. In conclusion, exposure of the bovine oocyte to PFHxS during the narrow window of IVM affected subsequent embryonic development, as reflected by morphological and mo- lecular changes. This suggests that PFHxS interferes with the final nuclear and cytoplasmic maturation of the oocyte leading to decreased developmental competence to blastocyst stage.
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| 43. |
- Juckes, Martin N., et al.
(författare)
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Millennial temperature reconstruction intercomparison and evaluation
- 2007
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Ingår i: Climate of the Past. - 1814-9324. ; 3, s. 591-609
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Tidskriftsartikel (refereegranskat)abstract
- There has been considerable recent interest in paleoclimate reconstructions of the temperature history of the last millennium. A wide variety of techniques have been used. The interrelation among the techniques is sometimes unclear, as different studies often use distinct data sources as well as distinct methodologies. Here recent work is reviewed and some new calculations performed with an aim to clarifying the consequences of the different approaches used. A range of proxy data collections introduced by different authors is used to estimate Northern Hemispheric annual mean temperatures with two reconstruction algorithms: (1) inverse regression and, (2) compositing followed by variance matching (CVM). It is found that inverse regression tends to give large weighting to a small number of proxies and that the second approach (CVM) is more robust to varying proxy input. The choice of proxy records is one reason why different reconstructions show different ranges. A reconstruction using 13 proxy records extending back to AD 1000 shows a maximum pre-industrial temperature of 0.25 K (relative to the 1866 to 1970 mean). The standard error on this estimate, based on the residual in the calibration period, is 0.14 K. Instrumental temperatures for two recent years (1998 and 2005) have exceeded the pre-industrial estimated maximum by more than 4 standard deviations of the calibration period residual.
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| 47. |
- Karlsson, Kristin C., et al.
(författare)
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A population pharmacokinetic model of gabapentin developed in nonparametric adaptive grid and nonlinear mixed effects modeling
- 2009
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Ingår i: Therapeutic Drug Monitoring. - 0163-4356 .- 1536-3694. ; 31:1, s. 86-94
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Tidskriftsartikel (refereegranskat)abstract
- Gabapentin is used in analgesic treatment of neuropathic pain, and large interindividual variation has been observed in the pharmacokinetics (PK) of the drug. The aim of this study was to develop a population PK model for gabapentin appropriate for monitoring patients with neuropathic pain and for individualizing their dose regimens. Steady-state serum concentrations of gabapentin, distributed over a dosage interval, were obtained from 16 adult patients. Data were analyzed with an iterative 2-stage Bayesian and a nonparametric adaptive grid algorithm (NPAG) (USC*PACK) and with nonlinear mixed effects modeling (NONMEM). Compartmental population models for gabapentin PK were developed in NPAG and NONMEM using creatinine clearance and body weight as covariates. Bioavailability was included in the models as a function of dose by using a hyperbolic function derived from data previously reported in the literature. The mean population parameter estimates from the final NPAG model predicted individual serum concentrations reasonably well. The models developed in NONMEM provided additional information about the relevance of the various possible covariates and also allowed for further evaluation by simulation from the model. The population PK model may be utilized in the MM-USCPACK monitoring software (MM: multiple model dosage design) for predicting and achieving individually optimized steady-state serum concentrations of gabapentin.
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