| 1. |
- Rosendahl, J, et al.
(författare)
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Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- 2018
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Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 67:10, s. 1855-1863
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Tidskriftsartikel (refereegranskat)abstract
- Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
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| 2. |
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Context-aware, Autonomous and Smart Architectures (CASA@ECSA 2017)
- 2017
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Proceedings (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Software is becoming more and more aware of its execution context. Decisions made at design time are moved at run time to enhance the services offered by the software. The Context-aware, Autonomous, and Smart Architectures (CASA) workshop aims to address the issues and challenges raised by the development and evaluation of software that is context-aware, dynamic, autonomous, smart, adaptive, selfmanaged. Novel approaches are needed to face the new issues raised by such software. Further, existing architectural solutions should be adapted and improved to meet the dynamic requirements of today systems.
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| 3. |
- Wang, X., et al.
(författare)
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Weak first-order quantum phase transition in the spin-tetrahedron system Cu(2)Te(2)O(5)Br(2) without lattice contributions
- 2011
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 83:13, s. 134403-
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Tidskriftsartikel (refereegranskat)abstract
- Under pressure the spin tetrahedron system Cu(2)Te(2)O(5)Br(2) shows a softening of the collective magnetic mode whereas the energy of local spin-exchange processes increases. This apparent contradiction is due to the system's proximity to a quantum critical point induced by competing interactions that effectively decouple the tetrahedra. The high-pressure state is therefore nonmagnetic and dominated by valence bond excitations. Anomalies in the frequency and the intensity of magnetic Raman scattering are evidence for a weakly discontinuous evolution of the quantum critical state. In contrast, structural parameters as well as optical phonon modes evolve continuously with pressure without any sign for discontinuous criticality. No new low-energy excitations are observed. In contrast, the expected fingerprints of the spin-liquid phase are broadened due to Dzyaloshinskii-Moriya interactions.
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| 5. |
- Isakov, S V, et al.
(författare)
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Magnetization process of spin ice in a [111] magnetic field
- 2004
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Ingår i: Physical Review B. - : American Physical Society. - 1550-235X. ; 70:10, s. 104418-
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Tidskriftsartikel (refereegranskat)abstract
- Spin ice in a magnetic field in the [111] direction displays two magnetization plateaus: one at saturation and an intermediate one with finite entropy. We study the crossovers between the different regimes from a point of view of (entropically) interacting defects. We develop an analytical theory for the nearest-neighbor spin ice model, which covers most of the magnetization curve. We find that the entropy is nonmonotonic, exhibiting a giant spike between the two plateaus. This regime is described by a monomer-dimer model with tunable fugacities. At low fields, we develop an RG treatment for the extended string defects, and we compare our results to extensive Monte Carlo simulations. We address the implications of our results for cooling by adiabatic (de)magnetization.
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| 9. |
- Prakash, A, et al.
(författare)
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Deliverable D6.3 : Trials and experimentation (cycle 3)
- 2022
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Rapport (refereegranskat)abstract
- This deliverable presents the third and final cycle of trials and experimentation activities executed over 5GENESIS facilities. The document is the continuation of deliverables D6.1 and D6.2, in the sense that it captures tests carried out over the evolved infrastructures hosting 5GENESIS facilities following the methodology defined in the previous editions of this deliverable. The tests reported in this document focus on i) the final 5G infrastructure deployments that includes radio and core elements mostly in Stand-Alone (SA) deployment configurations based on commercial and open implementations, and ii) the various use cases/applications, some of them also involving field trials. Most of the tests described herein, especially the generic/lab ones are performed using the Open5GENESIS experimentation suite.
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