| 1. |
- Naehrlich, L., et al.
(författare)
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Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020
- 2021
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Ingår i: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993. ; 20:4, s. 566-577
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Tidskriftsartikel (refereegranskat)abstract
- Background: Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Methods: We used the 38-country European Cystic Fibrosis Society Patient Registry (ECFSPR) to collect case data about pwCF and SARS-CoV-2 infection. Results: Up to 30 June 2020, 16 countries reported 130 SARS-CoV-2 cases in people with CF, yielding an incidence of 2.70/10 0 0 pwCF. Incidence was higher in lung-transplanted patients (n = 23) versus non transplanted patients (n = 107) (8.43 versus 2.36 cases/10 0 0). Incidence was higher in pwCF versus the age-matched general population in the age groups < 15, 15-24, and 25-49 years (p < 0.001), with similar trends for pwCF with and without lung transplant. Compared to the general population, pwCF (regardless of transplantation status) had significantly higher rates of admission to hospital for all age groups with available data, and higher rates of intensive care, although not statistically significant. Most pwCF recovered (96.2%), however 5 died, of whom 3 were lung transplant recipients. The case fatality rate for pwCF (3.85%, 95% CI: 1.26-8.75) was non-significantly lower than that of the general population (7.46%; p = 0.133). Conclusions: SARS-CoV-2 infection can result in severe illness and death for pwCF, even for younger patients and especially for lung transplant recipients. PwCF should continue to shield from infection and should be prioritized for vaccination. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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| 2. |
- Carr, S.B., et al.
(författare)
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Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
- 2022
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Ingår i: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993. ; 21:4, s. E221-E231
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Tidskriftsartikel (refereegranskat)abstract
- Background: This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen. Results: SARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were solid-organ transplant recipients. 74.5% were symptomatic and 22% were admitted to hospital. In the non-transplanted cohort, 39.5% of patients with ppFEV1<40% were hospitalised with oxygen verses 3.2% with ppFEV >70%: a 17-fold increase in odds. Worse outcomes were independently associated with older age, non-white race, underweight body mass index, and CF-related diabetes. Prescription of highly effective CFTR modulator therapies was associated with a significantly reduced odds of being hospitalised with oxygen (AOR 0.43 95%CI 0.31-0.60 p<0.001). Transplanted patients were hospitalised with supplemental oxygen therapy (21.9%) more often than non-transplanted (8.8%) and was independently associated with the primary outcome (Adjusted OR 2.45 95%CI 1.27-4.71 p=0.007). Conclusions: This is the first study to show that there is a protective effect from the use of CFTR modulator therapy and that people with CF from an ethnic minority are at more risk of severe infection with SARS-CoV-2. © 2022
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| 3. |
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| 4. |
- Mondejar, M. E., et al.
(författare)
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A review of the use of organic Rankine cycle power systems for maritime applications
- 2018
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Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1879-0690 .- 1364-0321. ; 91, s. 126-151
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Forskningsöversikt (refereegranskat)abstract
- Diesel engines are by far the most common means of propulsion aboard ships. It is estimated that around half of their fuel energy consumption is dissipated as low-grade heat. The organic Rankine cycle technology is a well-established solution for the energy conversion of thermal power from biomass combustion, geothermal reservoirs, and waste heat from industrial processes. However, its economic feasibility has not yet been demonstrated for marine applications. This paper aims at evaluating the potential of using organic Rankine cycle systems for waste heat recovery aboard ships. The suitable vessels and engine heat sources are identified by estimating the total recoverable energy. Different cycle architectures, working fluids, components, and control strategies are analyzed. The economic feasibility and integration on board are also evaluated. A number of research and development areas are identified in order to tackle the challenges limiting a widespread use of this technology in currently operating vessels and new-buildings. The results indicate that organic Rankine cycle units recovering heat from the exhaust gases of engines using low-sulfur fuels could yield fuel savings between 10% and 15%.
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| 5. |
- Baldasso, Enrico, et al.
(författare)
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Prediction of the annual performance of marine organic Rankine cycle power systems
- 2018
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Ingår i: ECOS 2018 - Proceedings of the 31st International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems.
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Konferensbidrag (refereegranskat)abstract
- The increasing awareness about the environmental impact of shipping and the increasingly stricter regulations introduced by the International Maritime Organization are driving the development of solutions to reduce the pollutant emissions from ships. While some previous studies focused on the implementation of a specific technology, others considered a wider perspective and investigated the feasibility of the integration of various technologies on board vessels. Among the screened technologies, organic Rankine cycle (ORC) power systems represent a viable solution to utilize the waste heat contained in the main engine exhaust gases to produce additional power for on board use. The installation of ORC power systems on board ships could result in a reduction of the CO 2 emissions by 5 – 10 %. Although a number of methods to derive the optimal design of ORC units in marine applications have been proposed, these methods are complex, computationally expensive and require specialist knowledge to be included as part of a general optimization procedure to define the optimal set of technologies to be implemented on board a vessel. This study presents a novel method to predict the performance of ORC units installed on board vessels, based upon the characteristics of the main engine exhaust gases and the ship sailing profile. The method is not computationally intensive, and is therefore suitable to be used in the context of large optimization problems, such as holistic optimization and evaluation of a ship performance given the operational profile, weather and route. The model predicted the annual energy production of two case studies with an accuracy within 4 %.
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| 6. |
- Baldasso, Enrico, et al.
(författare)
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Technical and economic feasibility of organic Rankine cycle-based waste heat recovery systems on feeder ships: Impact of nitrogen oxides emission abatement technologies
- 2019
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Ingår i: Energy Conversion and Management. - : Elsevier BV. - 0196-8904. ; 183, s. 577-589
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Tidskriftsartikel (refereegranskat)abstract
- The International Maritime Organization recently revised the regulations concerning nitrogen and sulphur oxides emissions from commercial ships. In this context, it is important to investigate how emission abatement technologies capable of meeting the updated regulation on nitrogen oxides emissions affect the performance of waste heat recovery units to be installed on board new vessels. The objective of this paper is to assess the potential fuel savings of installing an organic Rankine cycle unit on board a hypothetical liquefied natural gas-fuelled feeder ship operating inside emission control areas. The vessel complies with the updated legislation on sulphur oxides emissions by using a dual fuel engine. Compliance with the nitrogen oxides emission regulation is reached by employing either a high or low-pressure selective catalytic reactor, or an exhaust gas recirculation unit. A multi-objective optimization was carried out where the objective functions were the organic Rankine cycle unit annual electricity production, the volume of the heat exchangers, and the net present value of the investment. The results indicate that the prospects for attaining a cost-effective installation of an organic Rankine unit are larger if the vessel is equipped with a low-pressure selective catalytic reactor or an exhaust gas recirculation unit. Moreover, the results suggest that the cost-effectiveness of the organic Rankine cycle units is highly affected by fuel price and the waste heat recovery boiler design constraints.
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| 7. |
- Mondejar, Maria E., et al.
(författare)
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Power generation from low heat sources
- 2014
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Ingår i: Advances in Energy Research and Development. - 9780989559010 ; , s. 49-82
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Bokkapitel (refereegranskat)abstract
- In this chapter a thorough review of the latest research findings on power generation from non-conventional low heat sources is presented. Main discoveries and results of research works ranging from source exploitation technologies to final power production are reported and discussed to offer an overview of their potential. Firstly the concept of low-grade source is presented and the main energy sources in this group (i.e. geothermal energy, solar thermal systems, industrial waste heat and ocean thermal energy) are introduced. Each of them is briefly described and the latest developments and improvements on the technologies for their exploitation are enumerated. Afterwards the state-of-the-art available power cycles for the conversion of low heat into electricity are reported. Only thermal power conversion technologies are presented due to their higher presence in commercial applications and their potential for small scale power generation. Among these technologies, last findings and results on organic Rankine cycles (ORC) and power cycles based on working fluid mixtures (e.g. Kalina cycle) are described. A special emphasis is placed on organic Rankine cycles (ORC) since over the last few years this technology has experienced a significant global growth, boosted by their viable performance and the inherited knowledge from the refrigeration industry. In addition, the suitability of less known technologies such as Stirling cycles and their current development status and perspectives are also commented. After this review it follows an examination of the implementation of these technologies in present power production systems. Discussion will be provided on which are the current barriers that the mentioned technologies are facing for their introduction or during their operation. On the other hand, practical restrictions concerning the availability of suitable technology, environmental requirements or economic viability are stated. Limitations regarding thermodynamic and technological aspects, as well as operational concerns will be considered of special interest. In the final section we deal with the future scenario for the integration of small-scale power generation. Potential solutions for overcoming technology development barriers are presented and directions of current research works on this topic are pointed out.
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