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Sökning: WFRF:(Montanelli Alessandro)

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1.
  • Dragisic, Zlatan, et al. (författare)
  • Results of the Ontology Alignment Evaluation Initiative 2014
  • 2014
  • Ingår i: International Workshop on Ontology Matching. ; , s. 61-104
  • Konferensbidrag (refereegranskat)abstract
    • Ontology matching consists of finding correspondences between se-mantically related entities of two ontologies. OAEI campaigns aim at comparingontology matching systems on precisely defined test cases. These test cases canuse ontologies of different nature (from simple thesauri to expressive OWL on-tologies) and use different modalities, e.g., blind evaluation, open evaluation andconsensus. OAEI 2014 offered 7 tracks with 9 test cases followed by 14 partici-pants. Since 2010, the campaign has been using a new evaluation modality which provides more automation to the evaluation. This paper is an overall presentationof the OAEI 2014 campaign.
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2.
  • Jaillon, Sébastien, et al. (författare)
  • The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection.
  • 2014
  • Ingår i: Immunity. - : Elsevier BV. - 1074-7613. ; 40:4, s. 621-632
  • Tidskriftsartikel (refereegranskat)abstract
    • Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88-dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In cohorts of UTI-prone patients, PTX3 gene polymorphisms correlated with susceptibility to acute pyelonephritis and cystitis. These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs.
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