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- Gärdlund, B, et al.
(författare)
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Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases. The Heparin Prophylaxis Study Group.
- 1996
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Ingår i: The Lancet. - : Elsevier BV. - 0140-6736 .- 1474-547X. ; 347:9012, s. 1357-61
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Fatal pulmonary embolism and other thromboembolic complications are common in hospital inpatients. However, there is little evidence on the routine use of pharmacological thromboprophylaxis in non-surgical patients. We assessed the efficacy and safety of low-dose heparin in the prevention of hospital-acquired, clinically relevant, fatal pulmonary embolism in patients with infectious diseases.METHODS: Our study used the postrandomisation consent design. 19,751 consecutive patients, aged 55 years or older, admitted to departments of infectious diseases in six Swedish hospitals, were screened for inclusion in the randomised, controlled, unblinded, multicentre trial. Of the eligible patients, 5776 were assigned subcutaneous standard heparin (5000 IU every 12 h) until hospital discharge or for a maximum of 3 weeks; 5917 were assigned no prophylactic treatment (control group). We sought consent only from the heparin group. Follow-up was for 3 weeks after discharge from hospital or for a maximum of 60 days from randomisation. The primary endpoint was necropsy-verified pulmonary embolism of predefined clinical relevance.FINDINGS: By intention-to-treat analysis mortality was similar in the heparin and control groups (5.3 vs 5.6%, p = 0.39) and the median time from admission to death was 16 days in both groups (IQR 8-31 vs 6-28 days). Necropsy-verified pulmonary embolism occurred in 15 heparin-treated and 16 control-group patients. There was a significant difference between heparin and control groups in median time from randomisation to fatal pulmonary embolism (28 [24-36] vs 12.5 [10-20] days, p = 0.007). This difference corresponds to the duration of heparin prophylaxis. Non-fatal thromboembolic complications occurred in more of the control than of the heparin group (116 vs 70, p = 0.0012).INTERPRETATION: Our findings do not support the routine use of heparin prophylaxis for 3 weeks or less in large groups of non-surgical patients. Further studies are needed to investigate whether heparin prophylaxis of longer duration may prevent fatal pulmonary embolism.
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| 9. |
- Carlsson, N, et al.
(författare)
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IMPROVED SIZE HOMOGENEITY OF INP-ON-GAINP STRANSKI-KRASTANOW ISLANDS BY GROWTH ON A THIN GAP INTERFACE LAYER
- 1995
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Ingår i: Journal of Crystal Growth. - : Elsevier BV. - 0022-0248. ; 156:1-2, s. 23-29
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Tidskriftsartikel (refereegranskat)abstract
- Coherent InP nano-sized islands, embedded into GaInP, have been grown by metal-organic vapour phase epitaxy using the Stranski-Krastanow growth mode. Photoluminescence, atomic force microscopy and transmission electron microscopy studies show that the insertion of a thin ∼ 4 monolayer thick GaP layer affects the critical thickness of the subsequently deposited two-dimensional InP wetting layer, increasing it from ∼ 1.5 monolayers (without an inserted GaP layer) to ∼ 2.5 monolayers (with an inserted GaP layer). We demonstrate that the inserted GaP layer affects also the island formation. The bimodal size distribution of Stranski-Krastanow islands, typical for low InP coverages, can be overcome without island coalescence by deposition on top of the thin GaP layer, where a coverage of InP of about 3.5–4.5 monolayers results in the formation of almost only the larger, fully developed, pyramidal islands. Annealing experiments at growth temperature of 580°C show that these islands (base area ≈ 40 × 50 nm2, height ≈ 10–15 nm, surface density ≈ (1−2) × 109 cm−2) are rather stable in a time-scale over several minutes before they slowly undergo an Ostwald ripening process.
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- Chaudhary, Shilpi, et al.
(författare)
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Adsorption of 3-(triethoxysilyl)propionitrile on a rutile TiO2(110) surface : An X-ray photoelectron spectroscopy study
- 2020
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Ingår i: DAE Solid State Physics Symposium 2019. - : AIP Publishing. - 1551-7616 .- 0094-243X. - 9780735420250 ; 2265
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Konferensbidrag (refereegranskat)abstract
- The adsorption of 3-(triethoxysilyl)propionitrile (TESP) on a reduced rutile TiO2(110) surface has been investigated using synchrotron-based X-ray photoelectron spectroscopy in ultrahigh vacuum (UHV). We have studied TESP adsorption on two surface preparation of rutile TiO2 (110) to explore the role of surface defects. In the first preparation, the adsorption of TESP was studied on reduced TiO2 (110) surface at room temperature. In the second experiment TESP was adsorbed on the oxygen-treated TiO2 surface to quench the oxygen vacancies generated by UHVannealing of the TiO2 crystal. The molecular footprints of the TESP molecules confirms the adsorption on both types of TiO2(110) surfaces. In the case of the reduced surface, temperature-dependent XPS measurements show the thermal stability of TESP molecules up to 600 °C. The comparison of the nitrogen and carbon lineshapes for both preparations suggests different adsorption geometries on the reduced and oxygen-dosed surfaces. To the best of our knowledge, the UHV preparations and measurements of TESP adsorption on rutile TiO2 (110) in the present study are reported for the first time.
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- Forsen, E, et al.
(författare)
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Ultrasensitive mass sensor fully integrated with complementary metal-oxide-semiconductor circuitry
- 2005
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 87:4
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Tidskriftsartikel (refereegranskat)abstract
- Nanomechanical resonators have been monolithically integrated on preprocessed complementary metal-oxide-semiconductor (CMOS) chips. Fabricated resonator systems have been designed to have resonance frequencies up to 1.5 MHz. The systems have been characterized in ambient air and vacuum conditions and display ultrasensitive mass detection in air. A mass sensitivity of 4 ag/Hz has been determined in air by placing a single glycerine drop, having a measured weight of 57 fg, at the apex of a cantilever and subsequently measuring a frequency shift of 14.8 kHz. CMOS integration enables electrostatic excitation, capacitive detection, and amplification of the resonance signal directly on the chip.
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- Ghatnekar-Nilsson, Sara, et al.
(författare)
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Multi-frequency response from a designed array of micromechanical cantilevers fabricated using a focused ion beam
- 2006
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Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 17:20, s. 5233-5237
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate arrays of cantilevers with different lengths, fabricated by focused ion beam milling. The arrays of oscillators generate a spectrum of different resonant frequencies, where each frequency correlates to the corresponding individual cantilever. The frequency response from all the cantilevers is collected from a single measurement under the same environment and conditions for the entire array. The mass response of the system generated the same Delta f/f(0) for the cantilevers, within 0.1% accuracy. We denote the method MFSAC: multi-frequency signal analysis from an array of cantilevers. The simultaneous detection of several frequencies in one spectrum has great benefits in mass sensor applications, offering the possibility for true label-free detection.
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- Gourgon, C., et al.
(författare)
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Benchmarking of 50 nm features in thermal nanoimprint
- 2007
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Ingår i: Journal of Vacuum Science and Technology B. - : American Vacuum Society. - 1520-8567. ; 25:6, s. 2373-2378
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this benchmarking is to establish a comparison of several tools and processes used in thermal NIL with Si stamps at the nanoscale among the authors' laboratories. The Si stamps have large arrays of 50 nm dense lines and were imprinted in all these laboratories in a similar to 100 nm thick mr-18010E film. Other materials, such as mr-17010E, were also tested. Good patterns were obtained and some limitations were identified. Reducing the pressure to 15 bars enables the printing of 50 nm structures without pulling them off. At higher pressures, some bending effects resulting in pattern deformation were observed. It was proven that a pressure of 1.5 bars is sufficient to imprint perfect 50 nm lines. The influence of the antiadhesive layer and mold design has been characterized by the demonstration of pulled off lines in some cases. Moreover, it has been shown that the scatterometry method is particularly useful for the characterization of 50 nm lines and that the residual layer thickness corresponds to the theoretical estimate as long as the lines are well defined. One process was demonstrated which combines high reproducibility with high throughput, achieving a cycle time of 2 min. (c) 2007 American Vacuum Society.
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| 16. |
- Jensenius, M, et al.
(författare)
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Scrub typhus imported to Scandinavia
- 2006
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Ingår i: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 38:3, s. 200-202
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Tidskriftsartikel (refereegranskat)
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- Montelius, M., et al.
(författare)
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Chemical evolution of ytterbium in the Galactic disk
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
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Tidskriftsartikel (refereegranskat)abstract
- Context. Measuring the abundances of neutron-capture elements in Galactic disk stars is an important part of understanding key stellar and galactic processes. In the optical wavelength regime a number of different neutron-capture elements have been measured; however, only the s-process-dominated element cerium has been accurately measured for a large sample of disk stars from the infrared H band. The more r-process dominated element ytterbium has only been measured in a small subset of stars so far. Aims. In this study we aim to measure the ytterbium (Yb) abundance of local disk giants using the Yb II line at lambda(air) = 16 498 angstrom. We also compare the resulting abundance trend with cerium and europium abundances for the same stars to analyse the s- and r-process contributions. Methods. We analyse 30 K giants with high-resolution H band spectra using spectral synthesis. The very same stars have already been analysed using high-resolution optical spectra via the same method, but it was not possible to determine the abundance of Yb from those spectra due to blending issues for stars with [Fe/H] > -1. In the present analysis, we utilise the stellar parameters determined from the optical analysis. Results. We determined the Yb abundances with an estimated uncertainty for [Yb/Fe] of 0.1 dex. By comparison, we found that the [Yb/Fe] trend closely follows the [Eu/Fe] trend and has clear s-process enrichment in identified s-rich stars. This comparison confirms both that the validity of the Yb abundances is ensured and that the theoretical prediction that the s-/r-process contribution to the origin of Yb of roughly 40/60 is supported. Conclusions. These results show that, with a careful and detailed analysis of infrared spectra, reliable Yb abundances can be derived for a wider sample of cooler giants in the range -1.1 < [Fe/H] < 0.3. This is promising for further studies of the production of Yb and for the r-process channel, key for galactochemical evolution, in the infrared.
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- Nandakumar, G., et al.
(författare)
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M giants with IGRINS : III. Abundance trends for 21 elements in the solar neighborhood from high-resolution near-infrared spectra
- 2024
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Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 684
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Tidskriftsartikel (refereegranskat)abstract
- Context. To be able to investigate the chemical history of the entire Milky Way, it is imperative to also study its dust-obscured regions in detail, as this is where most of the mass lies. The Galactic Center is an example of such a region. Due to the intervening dust along the line of sight, near-infrared spectroscopic investigations are necessary to study this region of interest.Aims. The aim of this work is to demonstrate that M giants observed at high spectral resolution in the H- and K-bands (1.5–2.4 μm) can yield useful abundance ratio trends versus metallicity for 21 elements. These elements can then also be studied for heavily dust-obscured regions of the Galaxy, such as the Galactic Center. The abundance ratio trends will be important for further investigation of the Galactic chemical evolution in these regions.Methods. We observed near-infrared spectra of 50 M giants in the solar neighborhood at high signal-to-noise and at a high spectral resolution with the IGRINS spectrometer on the Gemini South telescope. The full H- and K-bands were recorded simultaneously at R = 45 000. Using a manual spectral synthesis method, we determined the fundamental stellar parameters for these stars and derived the stellar abundances for 21 atomic elements, namely, F, Mg, Si, S, Ca, Na, Al, K, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Y, Ce, Nd, and Yb. We systematically studied useful spectral lines of all these elements in the H- and K-bands.Results. We demonstrate that elements can be analyzed from H- and K-band high-resolution spectra, and we show which spectral lines can be used for an abundance analysis, identifying them line by line. We discuss the 21 abundance ratio trends and compare them with those determined from APOGEE and from the optical Giants in the Local Disk (GILD) sample. From high-resolution H- and K-band spectra, the trends of the heavy elements Cu, Zn, Y, Ce, Nd, and Yb can be retrieved. This opens up the nucleosynthetic channels, including the s-process and the r-process in dust-obscured populations. The [Mn/Fe] versus [Fe/H] trend is shown to be more or less flat at low metallicities, implying that existing non-local thermodynamic equilibrium correction is relevant.Conclusions. With high-resolution near-infrared spectra, it is possible to determine reliable abundance ratio trends versus metallicity for 21 elements, including elements formed in several different nucleosynthetic channels. It is also possible to determine the important neutron-capture elements, both s- and r-dominated elements. This opens up the possibility to study the chemical evolution in detail of dust-obscured regions of the Milky Way, such as the Galactic Center. The M giants are useful bright probes for these regions and for future studies of extra-galactic stellar populations. A careful analysis of high-quality spectra is needed to retrieve all of these elements, which are often from weak and blended lines. A spectral resolution of R ≳ 40 000 is a further quality that helps in deriving precise abundances for this range of elements. In comparison to APOGEE, we can readily obtain the abundances for Cu, Ce, Nd, and Yb from the H-band, demonstrating an advantage of analyzing high-resolution spectra.
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