| 1. |
- Bäck, S A, et al.
(author)
-
Verification of single beam treatment planning using a ferrous dosimeter gel and MRI (FeMRI)
- 1998
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In: Acta Oncologica. - 0284-186X. ; 37:6, s. 6-561
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Journal article (peer-reviewed)abstract
- A method for analysing and comparing treatment planning system (TPS) data and ferrous dosimeter gel measurements evaluated with MRI (FeMRI) was developed, including image processing to final absorbed dose images. Measurements were analysed according to this method and FeMRI data were thereby compared with the TPS-calculated dose distribution. For photons, differences between FeMRI- and TPS dose data were mainly within +/- 2%. Minor shortcomings found in both the FeMRI system and the TPS are explained and discussed. For electron beams, there was an overall good agreement. It was found that the TPS underestimates the lateral scattering dose outside the primary beam, but the reported dose difference corresponds to a small spatial deviation (less than 2 mm). It is important to consider this single beam data comparison when the method is extended to more complicated situations, for example when using several beams.
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| 2. |
- Johansson, S A, et al.
(author)
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Dosimeter gel and MR imaging for verification of calculated dose distributions in clinical radiation therapy
- 1997
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In: Acta Oncologica. - 0284-186X. ; 36:3, s. 90-283
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Journal article (peer-reviewed)abstract
- A dosimeter gel, based on an agarose gel infused with a ferrous sulphate solution and evaluated in a magnetic resonance scanner, was used for complete verification of calculated dose distributions. Two standard treatment procedures, treatment of cancer in the urinary bladder and treatment of breast cancer after modified radical mastectomy, were examined using pixel-by-pixel and dose volume histogram comparison. The dose distributions calculated with the dose planning system was in very good agreement with the measured ones. However, in the case of the more complicated breast cancer treatment, some discrepancies were found, mainly at the beam abutment region. This may be explained by field displacements errors and by a small limitation of the dose planning utilising small electron beams in this region. The dosimeter gel system have proven to be a useful tool for dosimetry in clinical radiation therapy applications.
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| 3. |
- Zankovych, S, et al.
(author)
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Nanoimprint-induced effects on electrical and optical properties of quantum well structures
- 2003
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In: Microelectronic Engineering (Proceedings of the 28th International Conference on Micro- and Nano-Engineering). - 0167-9317 .- 1873-5568. ; 67-8, s. 214-220
-
Conference paper (peer-reviewed)abstract
- A study of optical and transport properties of semiconductor quantum well structures subjected to nanoimprint lithography (NIL), with its pressure and temperature cycles, has been undertaken to ascertain if this lithography technique induces detrimental changes in these properties of the active layers over a range of pressures and temperatures, typically used in this printing process. Ga0.47In0.53As-InP and GaAs-Al0.3Ga0.7As multiple quantum well samples were investigated. Luminescence and the photoluminescence excitation were recorded before and after printing. No impact upon the luminescence energy and intensity were detected. From the photoluminescence spectrum no evidence of induced strain was found. The magneto transport experiments yielded no evidence of deterioration of neither the mobility nor carrier concentration of a two-dimensional electron gas in a modulation-doped Ga0.25In0.75As/InP heterostructure. Results on samples subjected to the NIL process over a wide range of applied pressure and temperature are presented and discussed. (C) 2003 Elsevier Science B.V. All rights reserved.
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| 4. |
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| 5. |
- Bunk, Richard, et al.
(author)
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Actomyosin motility on nanostructured surfaces
- 2003
-
In: Biochemical and Biophysical Research Communications. - 1090-2104. ; 301:3, s. 783-788
-
Journal article (peer-reviewed)abstract
- We have here, for the first time, used nanofabrication techniques to reproduce aspects of the ordered actomyosin arrangement in a muscle cell. The adsorption of functional heavy meromyosin (HMM) to five different resist polymers was first assessed. One group of resists (MRL-6000.1XP and ZEP-520) consistently exhibited high quality motility of actin filaments after incubation with HMM. A second group (PMMA-200, PMMA-950, and MRI-9030) generally gave low quality of motility with only few smoothly moving filaments. Based on these findings electron beam lithography was applied to a bi-layer resist system with PMMA-950 on top of MRL-6000.1XP. Grooves (100-200 nm wide) in the PMMA layer were created to expose the MRL-6000.1XP surface for adsorption of HMM and guidance of actin filament motility. This guidance was quite efficient allowing no U-turns of the filaments and approximately 20 times higher density of moving filaments in the grooves than on the surrounding PMMA.
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| 6. |
- Bunk, Richard, et al.
(author)
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Guiding molecular motors with nano-imprinted structures
- 2005
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In: Japanese Journal of Applied Physics. - 0021-4922. ; 44:5A, s. 3337-3340
-
Journal article (peer-reviewed)abstract
- This work, for the first time, demonstrates that nano-imprinted samples, with 100 nm wide polymer lines, can act as guides for molecular motors consisting of motor proteins actin and myosin. The motor protein function was characterized using fluorescence microscopy and compared to actomyosin motility on non-structured nitrocellulose surfaces. Our results open for further use of the nano-imprint technique in the production of disposable chips for bio-nanotechnological applications and miniaturized biological test systems. We discuss how the nano-imprinted motor protein assay system may be optimized and also how it compares to previously tested assay systems involving low-resolution UV-lithography and low throughput but high-resolution electron beam lithography.
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| 7. |
- Bunk, Richard, et al.
(author)
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Guiding motor-propelled molecules with nanoscale precision through silanized bi-channel structures
- 2005
-
In: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 16:6, s. 710-717
-
Journal article (peer-reviewed)abstract
- We report on the design and fabrication of a channel structure for high precision guidance and achieving excellent confinement properties for motor-propelled molecular shuttles. The techniques used to manufacture the channel structure are mainly e-beam lithography and selective monolayer functionalization. The structure consists of two lateral layers of concentric channels on a SiO2 surface made biocompatible with the molecular motors. The quality and advantages of the design are demonstrated by experiments using the motor proteins actin and myosin. The special channel geometry leads to stable biochemical conditions with full motor protein functionality. ATP is sufficiently supplied to all parts of the structure by dedicated service channels, as is the venting of ADP and P-i (inorganic phosphorus). Channels of different widths (100-700 nm) and shapes are fabricated and measurements made on them.
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| 8. |
- Bunk, Richard, et al.
(author)
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Towards a 'nano-traffic' system powered by molecular motors
- 2003
-
In: Microelectronic Engineering. - 1873-5568. ; 67-8, s. 899-904
-
Journal article (peer-reviewed)abstract
- In this work, we reconstructed in vitro the behavior of two motor proteins-myosin and actin-responsible for the mechanical action of muscle cells. By transferring this in vivo system to an artificial environment, we were able to study the interaction between the proteins in more detail, as well as investigating the central mechanism of force production. Nm-patterning by e-beam lithography (EBL) could restore parts of the in vivo protein order, essential for potential nanotechnological applications. Much work was put into establishing the necessary compatibility between the biological and nano-lithographical processes. A range of EBL-resists were tested for protein compatibility. One particular kind (MRL-6000.1XP) supported good actin filament motility, while another (PMMA-950) behaved in the opposite way. Taking advantage of these findings, nm-sized lines were created in a double-layer structure of the two resists. The lines were found to act as binding sites for myosin, and as rectifying guides for the linearized motion of actin filaments. Velocities around 5 mum/s were measured. (C) 2003 Elsevier Science B.V. All rights reserved.
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| 9. |
- Bäck, Sven, et al.
(author)
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Improvements in absorbed dose measurements for external radiation therapy using ferrous dosimeter gel and MR imaging (FeMRI)
- 1998
-
In: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 43, s. 261-
-
Journal article (peer-reviewed)abstract
- A ferrous gel, based on ferrous (Fe) sulphate and agarose, was used with a clinical magnetic resonance imaging (MRI) scanner to obtain relative dose distribution data from therapeutic photon and electron beams. The FeMRI gel was scanned using a new MRI acquisition protocol optimized for T1 measurements. Thorough comparisons with silicon semiconductor detector and ionization chamber measurements, as well as with Monte Carlo calculations, were performed in order to quantify the improvements obtained using FeMRI for dose estimations. Most of the relative doses measured with FeMRI were within 2% of the doses measured with other methods. The larger discrepancies (2-4%) found at shallow depths are discussed. The uncertainty in relative dose measurements using FeMRI was significantly improved compared with previously reported results (5-10%, one standard deviation, 1 SD), and is today between 1.6% and 3.3% (depending on dose level, 2 SD). This corresponds to an improvement in the minimum detectable dose (3 SD above background) from approximately 2 Gy to better than 0.6 Gy. The results obtained in this study emphasize the importance of obtaining basic FeMRI dose data before the method is extended to complicated treatment regimes.
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| 10. |
- Carlberg, Patrick, et al.
(author)
-
Nanoimprint - a tool for realizing nano-bio research
- 2004
-
In: 2004 4th IEEE Conference on Nanotechnology. - 0780385365 ; , s. 199-200
-
Conference paper (peer-reviewed)abstract
- In this paper, we present a status report on how implementation of nanoimprint lithography has advanced our research. Contact guidance nerve growth experiments have so far primarily been done on micrometer-structured surfaces. We have made a stamp with 17 areas of different, submicron, line width and spacing covering a total 2.6 mm
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| 11. |
- Chaudhary, Shilpi, et al.
(author)
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Adsorption of 3-(triethoxysilyl)propionitrile on a rutile TiO2(110) surface : An X-ray photoelectron spectroscopy study
- 2020
-
In: DAE Solid State Physics Symposium 2019. - : AIP Publishing. - 1551-7616 .- 0094-243X. - 9780735420250 ; 2265
-
Conference paper (peer-reviewed)abstract
- The adsorption of 3-(triethoxysilyl)propionitrile (TESP) on a reduced rutile TiO2(110) surface has been investigated using synchrotron-based X-ray photoelectron spectroscopy in ultrahigh vacuum (UHV). We have studied TESP adsorption on two surface preparation of rutile TiO2 (110) to explore the role of surface defects. In the first preparation, the adsorption of TESP was studied on reduced TiO2 (110) surface at room temperature. In the second experiment TESP was adsorbed on the oxygen-treated TiO2 surface to quench the oxygen vacancies generated by UHVannealing of the TiO2 crystal. The molecular footprints of the TESP molecules confirms the adsorption on both types of TiO2(110) surfaces. In the case of the reduced surface, temperature-dependent XPS measurements show the thermal stability of TESP molecules up to 600 °C. The comparison of the nitrogen and carbon lineshapes for both preparations suggests different adsorption geometries on the reduced and oxygen-dosed surfaces. To the best of our knowledge, the UHV preparations and measurements of TESP adsorption on rutile TiO2 (110) in the present study are reported for the first time.
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| 12. |
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| 13. |
- Finder, C, et al.
(author)
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Fluorescence microscopy for quality control in nanoimprint lithography
- 2003
-
In: Microelectronic Engineering (Proceedings of the 28th International Conference on Micro- and Nano-Engineering). - 0167-9317 .- 1873-5568. ; 67-8, s. 623-628
-
Conference paper (peer-reviewed)abstract
- Fluorescence microscopy is introduced as a low cost quality control process for nanoimprint lithography. To depict imprinted structures down to 1 mum lateral size and to detect residues down to 100 nm lateral size, the standard printable polymer mr-18000 is labelled with less than 0.1 wt.% fluorescent dye. Three different types of stamps are used to determine the dependence of the shape and size of stamp features in a series of imprints. The quality of a stamp is given by the sticking polymer residues per unit area. Fluorescence light images as well as visible light images are analysed. Changes in the area of the stamp covered with polymer as a function of the number of imprints is summarised in a statistical process chart. Adhesion was artificially induced in order to observe self cleaning of virgin stamps. They were detected and monitored, suggesting that this method is a suitable technique for quality control and that it could be easily adapted to the nanoimprint process. (C) 2003 Elsevier Science B.V. All rights reserved.
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| 14. |
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| 15. |
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| 16. |
- Gourgon, C., et al.
(author)
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Benchmarking of 50 nm features in thermal nanoimprint
- 2007
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In: Journal of Vacuum Science and Technology B. - : American Vacuum Society. - 1520-8567. ; 25:6, s. 2373-2378
-
Journal article (peer-reviewed)abstract
- The objective of this benchmarking is to establish a comparison of several tools and processes used in thermal NIL with Si stamps at the nanoscale among the authors' laboratories. The Si stamps have large arrays of 50 nm dense lines and were imprinted in all these laboratories in a similar to 100 nm thick mr-18010E film. Other materials, such as mr-17010E, were also tested. Good patterns were obtained and some limitations were identified. Reducing the pressure to 15 bars enables the printing of 50 nm structures without pulling them off. At higher pressures, some bending effects resulting in pattern deformation were observed. It was proven that a pressure of 1.5 bars is sufficient to imprint perfect 50 nm lines. The influence of the antiadhesive layer and mold design has been characterized by the demonstration of pulled off lines in some cases. Moreover, it has been shown that the scatterometry method is particularly useful for the characterization of 50 nm lines and that the residual layer thickness corresponds to the theoretical estimate as long as the lines are well defined. One process was demonstrated which combines high reproducibility with high throughput, achieving a cycle time of 2 min. (c) 2007 American Vacuum Society.
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| 17. |
- Gärdlund, B, et al.
(author)
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Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases. The Heparin Prophylaxis Study Group.
- 1996
-
In: The Lancet. - : Elsevier BV. - 0140-6736 .- 1474-547X. ; 347:9012, s. 1357-61
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Fatal pulmonary embolism and other thromboembolic complications are common in hospital inpatients. However, there is little evidence on the routine use of pharmacological thromboprophylaxis in non-surgical patients. We assessed the efficacy and safety of low-dose heparin in the prevention of hospital-acquired, clinically relevant, fatal pulmonary embolism in patients with infectious diseases.METHODS: Our study used the postrandomisation consent design. 19,751 consecutive patients, aged 55 years or older, admitted to departments of infectious diseases in six Swedish hospitals, were screened for inclusion in the randomised, controlled, unblinded, multicentre trial. Of the eligible patients, 5776 were assigned subcutaneous standard heparin (5000 IU every 12 h) until hospital discharge or for a maximum of 3 weeks; 5917 were assigned no prophylactic treatment (control group). We sought consent only from the heparin group. Follow-up was for 3 weeks after discharge from hospital or for a maximum of 60 days from randomisation. The primary endpoint was necropsy-verified pulmonary embolism of predefined clinical relevance.FINDINGS: By intention-to-treat analysis mortality was similar in the heparin and control groups (5.3 vs 5.6%, p = 0.39) and the median time from admission to death was 16 days in both groups (IQR 8-31 vs 6-28 days). Necropsy-verified pulmonary embolism occurred in 15 heparin-treated and 16 control-group patients. There was a significant difference between heparin and control groups in median time from randomisation to fatal pulmonary embolism (28 [24-36] vs 12.5 [10-20] days, p = 0.007). This difference corresponds to the duration of heparin prophylaxis. Non-fatal thromboembolic complications occurred in more of the control than of the heparin group (116 vs 70, p = 0.0012).INTERPRETATION: Our findings do not support the routine use of heparin prophylaxis for 3 weeks or less in large groups of non-surgical patients. Further studies are needed to investigate whether heparin prophylaxis of longer duration may prevent fatal pulmonary embolism.
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| 18. |
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| 19. |
- Jensenius, M, et al.
(author)
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Scrub typhus imported to Scandinavia
- 2006
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In: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 38:3, s. 200-202
-
Journal article (peer-reviewed)
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| 20. |
- Koksharov, Yu.A., et al.
(author)
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Magnetostatic interactions in planar ring-like nanoparticle structures
- 2006
-
In: Thin Solid Films. - : Elsevier BV. - 0040-6090. ; 515, s. 731-734
-
Journal article (peer-reviewed)abstract
- Numerical calculations of equilibrium state energies and local magnetic fields in planar ring-like nanoparticle structures were performed. The dipole–dipole, Zeeman and magnetic anisotropy interactions were included into the model. The result of their competition depends on the value of the external magnetic field, magnetic parameters of an individual nanoparticle, size and shape of the structures. Flux-closed vortexes, single domain, two- domain ‘‘onion’’-like, ‘‘hedgehog’’-like and more complex spin structures can be realized. The critical field, providing a sharp transition from the flux-closed vortex to the ‘‘onion’’-like state, can be regulated by a variation of the particle magnetization and anisotropy constant, their easy directions, and particle space arrangement.
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| 21. |
- Lind, Karin, et al.
(author)
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Non-LTE abundance corrections for late-type stars from 2000Å to 3 μm
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
-
Journal article (peer-reviewed)abstract
- Context. It is well known that cool star atmospheres depart from local thermodynamic equilibrium (LTE). Making an accurate abundance determination requires taking those effects into account, but the necessary non-LTE (hereafter NLTE) calculations are often lacking.Aims. Our goal is to provide detailed estimates of NLTE effects for FGK type stars for all spectral lines from the ultraviolet (UV) to the near infrared (NIR) that are potentially useful as abundance diagnostics. The first paper in this series focusses on the light elements Na, Mg, and Al.Methods. The code PySME was used to compute curves of growth for 2158 MARCS model atmospheres in the parameter range 3800 < T-eff < 8000 K, 0.0 < log(g) < 5.5, and -5 < [Fe/H] < +0.5. Two microturbulence values, 1 and 2 km s(-1), and nine abundance points spanning -1 < [X/Fe] < 1 for element X, are used to construct individual line curves of growth by calculating the equivalent widths of 35 Na lines, 134 Mg lines, and 34 Al lines. The lines were selected in the wavelength range between 2000 angstrom and 3 mu m.Results. We demonstrate the power of the new grids with LTE and NLTE abundance analysis by means of equivalent width measurements of five benchmark stars; the Sun, Arcturus, HD 84937, HD 140283 and HD 122563. For Na, the NLTE abundances are lower than in LTE and show markedly reduced line-to-line scatter in the metal-poor stars. For Mg, we confirm previous reports of a significant similar to 0.25 dex LTE ionisation imbalance in metal-poor stars that is only slightly improved in NLTE (similar to 0.18 dex). LTE abundances based on Mg II lines agree better with models of Galactic chemical evolution. For Al, NLTE calculations strongly reduce an similar to 0.6 dex ionisation imbalance seen in LTE for the metal-poor stars. The abundance corrections presented in this work are in good agreement with previous studies for the subset of lines that overlap, with the exception of strongly saturated lines.Conclusions. A consensus between different abundance diagnostics is the most powerful tool available to stellar spectroscopists to assess the accuracy of the models. Here we report that NLTE abundance analysis in general leads to improved agreement, in particular for metal-poor stars. The residual scatter is believed to be caused mainly by unresolved blends and/or poor atomic data, with the notable exception of Mg, which calls for further investigation.
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| 22. |
- Magnusson, Peter S., et al.
(author)
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Performance Debugging and Tuning using an Instruction-Set Simulator
- 1997. - 1
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Reports (other academic/artistic)abstract
- Instruction-set simulators allow programmers a detailed level of insight into, and control over, the execution of a program, including parallel programs and operating systems. In principle, instruction set simulation can model any target computer and gather any statistic. Furthermore, such simulators are usually portable, independent of compiler tools, and deterministic-allowing bugs to be recreated or measurements repeated. Though often viewed as being too slow for use as a general programming tool, in the last several years their performance has improved considerably. We describe SIMICS, an instruction set simulator of SPARC-based multiprocessors developed at SICS, in its rôle as a general programming tool. We discuss some of the benefits of using a tool such as SIMICS to support various tasks in software engineering, including debugging, testing, analysis, and performance tuning. We present in some detail two test cases, where we've used SimICS to support analysis and performance tuning of two applications, Penny and EQNTOTT. This work resulted in improved parallelism in, and understanding of, Penny, as well as a performance improvement for EQNTOTT of over a magnitude. We also present some early work on analyzing SPARC/Linux, demonstrating the ability of tools like SimICS to analyze operating systems.
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| 23. |
- Mansson, A, et al.
(author)
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Actin-based molecular motors for cargo transportation in nanotechnology - Potentials and challenges
- 2005
-
In: IEEE Transactions on Advanced Packaging. - 1521-3323. ; 28:4, s. 547-555
-
Journal article (peer-reviewed)abstract
- Here, we review the use of actin-based motors, (myosins; e.g., the molecular motor of muscle) in. nanotechnology. The review starts from the viewpoints of the molecular motors as being important devices responsible of cargo transportation in the cell and end in discussions about their employment in nanotechnological applications. First, we describe basic biophysics of the myosin motors with focus on their involvement in cargo transportation in the living cell, leading us over into a discussion about in vitro motility assays. These are biological test systems where the myosin-induced translocation of actin filaments is studied on an artificial surface outside the cell. Then follows a review about modified motility assays for production of ordered motion. Here, we discuss ours and others' work with regards to making micro- and nanostructured surfaces and channels where the position and direction of movement produced by molecular motors is controlled. In this section, we consider the role of the channel size in promoting unidirectional myosin-induced motion of actin filaments. Furthermore, we consider the usefulness of surface modifications, e.g., various silanization procedures in order to promote and hinder molecular motility, respectively. Particularly, we describe our latest test system being both morphologically and chemically nanostructured giving us unsurpassed possibilities to perform functional studies as well as extremely good spatio-temporal control. Then follows a section about nanotechnological cargo transportation systems based on the actomyosin motor system. For instance, we present results of attaching fluorescent quantum dots as cargoes to the actin filaments. In this section, we also discuss the possibilities of having cargo attachment and detachment being performed on demand. Finally, we consider the usefulness of molecular motors for lab-on-a-chip applications and the requirements for incorporating these motors in commercially viable devices. In this context, the significant potential of the actomyosin motor system to overcome traditional limitations of micro- and nanofluidics is stressed.
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| 24. |
- Mansson, A, et al.
(author)
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In vitro sliding of actin filaments labelled with single quantum dots
- 2004
-
In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 314:2, s. 529-534
-
Journal article (peer-reviewed)abstract
- We recently refined the in vitro motility assay for studies of actomyosin function to achieve rectified myosin induced sliding of actin filaments. This paves the way, both for detailed functional studies of actomyosin and for nanotechnological applications. In the latter applications it would be desirable to use actin filaments for transportation of cargoes (e.g., enzymes) between different predetermined locations on a chip. We here describe how single quantum dot labelling of isolated actin filaments simultaneously provides handles for cargo attachment and bright and photostable fluorescence labels facilitating cargo detection and filament tracking. Labelling was achieved with preserved actomyosin function using streptavidin-coated CdSe quantum dots (Qdots). These nanocrystals have several unique physical properties and the present work describes their first use for functional studies of isolated proteins outside the cell. The results, in addition to the nanotechnology developments, open for new types of in vitro assays of isolated biomolecules. (C) 2003 Elsevier Inc. All rights reserved.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- MONTELIUS, L, et al.
(author)
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CHARACTERIZATION OF THE MN ACCEPTOR LEVEL IN GAAS
- 1988
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In: Journal of Applied Physics. - CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 : AIP Publishing. - 0021-8979 .- 1089-7550. ; 64, s. 1564-1567
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Journal article (peer-reviewed)
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| 29. |
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| 30. |
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| 31. |
- Montelius, S, et al.
(author)
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Skin rash for 15 years
- 1998
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In: Lancet (London, England). - 0140-6736. ; 352:9138, s. 1438-1438
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Journal article (peer-reviewed)
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| 32. |
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| 33. |
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| 34. |
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| 35. |
- Nyholm, Tufve, et al.
(author)
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A national approach for automated collection of standardized and population-based radiation therapy data in Sweden
- 2016
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In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 119:2, s. 344-350
-
Journal article (peer-reviewed)abstract
- Purpose: To develop an infrastructure for structured and automated collection of interoperable radiation therapy (RT) data into a national clinical quality registry. Materials and methods: The present study was initiated in 2012 with the participation of seven of the 15 hospital departments delivering RT in Sweden. A national RT nomenclature and a database for structured unified storage of RT data at each site (Medical Information Quality Archive, MIQA) have been developed. Aggregated data from the MIQA databases are sent to a national RT registry located on the same IT platform (INCA) as the national clinical cancer registries. Results: The suggested naming convention has to date been integrated into the clinical workflow at 12 of 15 sites, and MIQA is installed at six of these. Involvement of the remaining 3/15 RT departments is ongoing, and they are expected to be part of the infrastructure by 2016. RT data collection from ARIA (R), Mosaiq (R), Eclipse (TM), and Oncentra (R) is supported. Manual curation of RT-structure information is needed for approximately 10% of target volumes, but rarely for normal tissue structures, demonstrating a good compliance to the RT nomenclature. Aggregated dose/volume descriptors are calculated based on the information in MIQA and sent to INCA using a dedicated service (MIQA2INCA). Correct linkage of data for each patient to the clinical cancer registries on the INCA platform is assured by the unique Swedish personal identity number. Conclusions: An infrastructure for structured and automated prospective collection of syntactically inter operable RT data into a national clinical quality registry for RT data is under implementation. Future developments include adapting MIQA to other treatment modalities (e.g. proton therapy and brachytherapy) and finding strategies to harmonize structure delineations. How the RT registry should comply with domain-specific ontologies such as the Radiation Oncology Ontology (ROO) is under discussion.
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| 36. |
- Pfeiffer, K, et al.
(author)
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A comparison of thermally and photochemically cross-linked polymers for nanoimprinting
- 2003
-
In: Microelectronic Engineering. - 1873-5568. ; 67-8, s. 266-273
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Journal article (peer-reviewed)abstract
- The characteristics and benefits of two types of cross-linking prepolymers with low glass transition temperature (T-g) for nanoimprinting are reported. They are soluble in organic solvents and their solutions can be processed like those of common thermoplastics. The imprinted patterns receive high thermal and mechanical stability through cross-linking polymerization. The course of the polymerization was investigated to determine the appropriate conditions for the imprint process. In thermally cross-linked polymers mr-I 9000, the cross-linking occurs during imprinting. Process time and temperature depend on the polymerization rate. Volume shrinkage during the polymerization does not adversely affect imprinting. Photochemically cross-linked polymers mr-L 6000 make possible imprint temperatures below 100 T and short imprint times. The T-g of the prepolymer determines the imprint temperature. The cross-linking reaction and structural stabilization is performed after imprinting. 50-nm trenches and sub-50-nm dots confirm the successful application of the polymers.
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| 37. |
- Pfeiffer, K, et al.
(author)
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Polymer stamps for nanoimprinting
- 2002
-
In: Microelectronic Engineering. - 1873-5568. ; 61-2, s. 393-398
-
Journal article (peer-reviewed)abstract
- Stamp fabrication for nanoimprinting can be significantly simplified, when specialized crosslinking polymers are applied to pattern definition. The polymer patterns can be used as stamps themselves. Two possibilities are reported: (1) An e-beam sensitive resist was developed, which enables the fabrication of polymer-on-silicon stamps. Patterns with a feature size of 70 nm could be created. (2) Full plastic stamps were obtained by a casting-moulding technique, which enable pattern transfer from any conventional mould. The quality of the two stamp variants were proved by imprinting experiments. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- Seekamp, J, et al.
(author)
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Nanoimprinted passive optical devices
- 2002
-
In: Nanotechnology. - : IOP Publishing. - 0957-4484. ; 13:5, s. 581-586
-
Journal article (peer-reviewed)abstract
- We report on the feasibility and process parameters of nanoimprint lithography to fabricate low refractive index passive optical devices. Diffraction gratings printed in polymethylmethacrylate (PMMA) exhibit a sharp dispersion with a full width at half maximum of about 20 nm. Waveguides were printed in polystyrene (PS) on silicon oxide and had losses between 8-20 dB cm(-1) at wavelengths between 650-400 nm, respectively. Finally, one-dimensional photonic structures were also printed in PS and their transmission and morphology characterized. The expected Bragg peak was observed in transmission and atomic force microscopy images have shown a good pattern transfer. A square lattice was printed in PMMA and more than 40 print cycles were obtained, i.e., potentially more than 1000 imprints from one master stamp.
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| 42. |
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| 43. |
- Sundberg, M, et al.
(author)
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Silanized surfaces for in vitro studies of actomyosin function and nanotechnology applications
- 2003
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In: Analytical Biochemistry. - : Elsevier BV. - 1096-0309 .- 0003-2697. ; 323:1, s. 127-138
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Journal article (peer-reviewed)abstract
- We have previously shown that selective heavy meromyosin (HMM) adsorption to predefined regions of nanostructured polymer resist surfaces may be used to produce a nanostructured in vitro motility assay. However, actomyosin function was of lower quality than on conventional nitrocellulose films. We have therefore studied actomyosin function on differently derivatized glass surfaces with the aim to find a substitute for the polymer resists. We have found that surfaces derivatized with trimethylchlorosilane (TMCS) were superior to all other surfaces tested, including nitrocellulose. High-quality actin filament motility was observed up to 6 days after incubation with HMM and the fraction of motile actin filaments and the velocity of smooth sliding were generally higher on TMCS than on nitrocellulose. The actomyosin function on TMCS-derivatized glass and nitrocellulose is considered in relation to roughness and hydrophobicity of these surfaces. The results suggest that TMCS is an ideal substitute for polymer resists in the nanostructured in vitro motility assay. Furthermore, TMCS derivatized glass also seems to offer several advantages over nitrocellulose for HMM adsorption in the ordinary in vitro motility assay. (C) 2003 Elsevier Inc. All rights reserved.
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