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- Egeler, M. D., et al.
(författare)
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Understanding quality of life issues in patients with advanced melanoma: Phase 1 and 2 in the development of the EORTC advanced melanoma module
- 2024
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Ingår i: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 207
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We aimed to develop a European Organization for Research and Treatment of Cancer (EORTC) Quality of Life (QoL) module tailored for patients with advanced (resectable or unresectable stage III/IV) melanoma receiving immune checkpoint inhibitors or targeted therapy. Methods: Following the EORTC QoL Group module development guidelines, we conducted phases 1 and 2 of the development process. In phase 1, we generated a list of health-related (HR)QoL issues through a systematic literature review and semi-structured interviews with healthcare professionals (HCPs) and patients with advanced melanoma. In phase 2, these issues were converted into questionnaire items to create the preliminary module. Results: Phase 1: we retrieved 8006 articles for the literature review, of which 35 were deemed relevant, resulting in 84 HRQoL issues being extracted to create the initial issue list. Semi-structured interviews with 18 HCPs and 28 patients with advanced melanoma resulted in 28 issues being added to the initial issue list. Following EORTC module development criteria, 26 issues were removed, and two issues were added after review by patient advocates. Phase 2: To ensure uniformity and avoid duplication, 16 issues were consolidated into eight items. Additionally, an independent expert contributed one new item, resulting in a preliminary module comprising 80 HRQoL items. Conclusion: We identified a range of HRQoL issues (dry skin, xerostomia, and arthralgia) relevant to patients with stage III/IV melanoma. Future module development phases will refine the questionnaire. Once completed, this module will enable standardized assessment of HRQoL in patients with (locally) advanced melanoma.
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| 3. |
- Ganot, Noam, et al.
(författare)
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The GALEX-PTF Experiment. II. Supernova Progenitor Radius and Energetics via Shock-cooling Modeling
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 931:1
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Tidskriftsartikel (refereegranskat)abstract
- The radius and surface composition of an exploding massive star, as well as the explosion energy per unit mass, can be measured using early ultraviolet (UV) observations of core-collapse supernovae (CC SNe). We present the results from a simultaneous Galaxy Evolution Explorer (GALEX) and Palomar Transient Factory (PTF) search for early UV emission from SNe. We analyze five CC SNe for which we obtained near-UV (NUV) measurements before the first ground-based R-band detection. We introduce SOPRANOS, a new maximum likelihood fitting tool for models with variable temporal validity windows, and use it to fit the Sapir & Waxman shock-cooling model to the data. We report four Type II SNe with progenitor radii in the range of R* ≈ 600–1100 R⊙ and a shock velocity parameter in the range of vs* ≈ 2700–6000 km s−1 (E/M ≈ 2–8 × 1050 erg/M⊙) and one Type IIb SN with R* ≈ 210 R⊙ and vs* ≈ 11,000 km s−1 (E/M ≈ 1.8 × 1051 erg/M⊙). Our pilot GALEX/PTF project thus suggests that a dedicated, systematic SN survey in the NUV band, such as the wide-field UV explorer ULTRASAT mission, is a compelling method to study the properties of SN progenitors and SN energetics.
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| 4. |
- Soumagnac, Maayane T., et al.
(författare)
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SN 2018fif : The Explosion of a Large Red Supergiant Discovered in Its Infancy by the Zwicky Transient Facility
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 902:1
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Tidskriftsartikel (refereegranskat)abstract
- High-cadence transient surveys are able to capture supernovae closer to their first light than ever before. Applying analytical models to such early emission, we can constrain the progenitor stars' properties. In this paper, we present observations of SN 2018fif (ZTF 18abokyfk). The supernova was discovered close to first light and monitored by the Zwicky Transient Facility (ZTF) and the Neil Gehrels Swift Observatory. Early spectroscopic observations suggest that the progenitor of SN 2018fif was surrounded by relatively small amounts of circumstellar material compared to all previous cases. This particularity, coupled with the high-cadence multiple-band coverage, makes it a good candidate to investigate using shock-cooling models. We employ the SOPRANOS code, an implementation of the model by Sapir & Waxman and its extension to early times by Morag et al. Compared with previous implementations, SOPRANOS has the advantage of including a careful account of the limited temporal validity domain of the shock-cooling model as well as allowing usage of the entirety of the early UV data. We find that the progenitor of SN 2018fif was a large red supergiant with a radius of R = 744.0(-128.0)(+183.0) R-circle dot and an ejected mass of M-ej = 9.3(-5.8)(+0.4) M-circle dot. Our model also gives information on the explosion epoch, the progenitor's inner structure, the shock velocity, and the extinction. The distribution of radii is double-peaked, with smaller radii corresponding to lower values of the extinction, earlier recombination times, and a better match to the early UV data. If these correlations persist in future objects, denser spectroscopic monitoring constraining the time of recombination, as well as accurate UV observations (e.g., with ULTRASAT), will help break the extinction/radius degeneracy and independently determine both.
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| 5. |
- Susilo, Yusak O., et al.
(författare)
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The influence of individuals’ environmental attitudes and urban design features on their travel patterns in sustainable neighborhoods in the UK
- 2012
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Ingår i: Transportation Research Part D. - Stockholm : Centre for Transport Studies Stockholm, Swedish National Road & Transport Research Institute (VTI), KTH Royal Institute of Technology, S-WoPEc, Scandinavian Working Papers in Economics. - 1361-9209 .- 1879-2340. ; 17:3, s. 190-200
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper explores the influence of individuals’ environmental attitudes and urban design features on travel behavior, including mode choice. It uses data from residents of 13 new neighborhood UK developments designed to support sustainable travel. It is found that almost all respondents were concerned about environmental issues, but their views did not necessarily ‘match’ their travel behavior. Individuals’ environmental concerns only had a strong relationship with walking within and near their neighborhood, but not with cycling or public transport use. Residents’ car availability reduced public transport trips, walking and cycling. The influence of urban design features on travel behaviors was mixed, higher incidences of walking in denser, mixed and more permeable developments were not found and nor did residents own fewer cars than the population as a whole. Residents did, however, make more sustainable commuting trips than the population in general. Sustainable modes of travel were related to urban design features including secured bike storage, high connectivity of the neighborhoods to the nearby area, natural surveillance, high quality public realm and traffic calming. Likewise the provision of facilities within and nearby the development encouraged high levels of walking.
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