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Sökning: WFRF:(Morsy A)

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1.
  • 2021
  • swepub:Mat__t
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2.
  • Bravo, L, et al. (författare)
  • 2021
  • swepub:Mat__t
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3.
  • Tabiri, S, et al. (författare)
  • 2021
  • swepub:Mat__t
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4.
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5.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • New homogeneous and alternating Mn(II)-azido 1D systems
  • 2005
  • Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 24:4, s. 557-562
  • Tidskriftsartikel (refereegranskat)abstract
    • Reaction of sodium azide with manganese(II) and 4-amino-1,2,4-triazol or 3-chloropyridine leads to the 1D systems [Mn(N-3)(2) (4-amtr)(2)](,) (1) or {[Mn(N-3)(2)(3-Clpy)(2)]center dot 1/2(3-Clpy)}(n) (2), respectively. Compound 1 crystallises in the C2/m (monoclinic) group and consists of chains of Mn(II) cations bridged by double mu(1,3)-azido bridges in trans arrangement. Compound 2 crystallises in the I2/a (monoclinic) group and in this case the 1D system shows alternating double mu(1,1) and mu(1,3) bridges. Magnetic properties follow the expected antiferromagnetic (compound 1) and alternating ferro-antiferromagnetic (compound 2) behaviour. (c) 2005 Published by Elsevier Ltd.
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6.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • Synthesis, structure, network and thermal analysis of four 5-(pyrazinyl)tetrazolato copper(II) and cobalt(II) complexes
  • 2007
  • Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 26:7, s. 1531-1540
  • Tidskriftsartikel (refereegranskat)abstract
    • Three new copper complexes and one cobalt complex with 5-(pyrazinyl)tetrazolate anion, (pyztz)(-), as chelating bidentate ligand, were obtained by the reaction of pyrazinecarbonitrile with sodium azide in the presence of copper(II) nitrate or cobalt(II)chloride. Complexes of composition [Cu(pyztz)(2)(H2O)] (1) deep blue crystals, [Cu(pyztz)(2)(H2O)(2)] (2a) green crystals, [Co(pyztz)(2)(H2O)(2)] (2b) orange crystals, [Cu(pyztz)2(H2O)(2)] center dot (H2O) (3) blue crystals were obtained. The single crystal X-ray diffraction revealed that complex I has square pyramidal structure with one water molecule at apical and two pyrazine-tetrazolato ligands at basal sites, while structures of 2a, 2b and 3 consist of octahedrally coordinated metal ions, where two pyztz anions act as bidentate ligands via one of the pyrazine-N atoms and one of the tetrazole-N atoms in trans-positions and two trans water molecules. Complex 3 contains one extra lattice water molecule. Hydrogen bonds of the types O-H center dot center dot center dot O and O-H center dot center dot center dot N connect the mononuclear units to a three-dimensional network structure in 2 (a and b are isostructural) and 3. Although the H-bond patterns look complex it is shown that they can be related to the well-known three- and six-connected rutile net (rtl) in 2 and the four- and six-connected fsh-net in 3. (C) 2006 Elsevier Ltd. All rights reserved.
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7.
  • Chatron, N., et al. (författare)
  • Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy
  • 2020
  • Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 143:5, s. 1447-1461
  • Tidskriftsartikel (refereegranskat)abstract
    • Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathy caused by bi-allelic loss-of-function variants in GAD1, as presented by 11 patients from six independent consanguineous families. Seizure onset occurred in the first 2 months of life in all patients. All 10 patients, from whom early disease history was available, presented with seizure onset in the first month of life, mainly consisting of epileptic spasms or myoclonic seizures. Early EEG showed suppression-burst or pattern of burst attenuation or hypsarrhythmia if only recorded in the post-neonatal period. Eight patients had joint contractures and/or pes equinovarus. Seven patients presented a cleft palate and two also had an omphalocele, reproducing the phenotype of the knockout Gad1(-/-) mouse model. Four patients died before 4 years of age. GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the c-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylation of glutamic acid to form GABA. Our findings evoke a novel syndrome related to GAD67 deficiency, characterized by the unique association of developmental and epileptic encephalopathies, cleft palate, joint contractures and/or omphalocele.
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8.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • Synthesis, X-ray structure and anti-corrosion activity of two silver(I) pyrazino complexes
  • 2009
  • Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 28:13, s. 2794-2802
  • Tidskriftsartikel (refereegranskat)abstract
    • Two new silver(I) pyrazine complexes [Ag2(ampyz)(NO3)2]n, 1 and {[Ag(2,3-pyzdic)](NO3)}n, 2 (where ampyz = aminopyrazine, and 2,3-pyzdic = 2,3-pyrazinedicarboxamide) were synthesized and structurally characterized by X-ray single crystal structure analysis. Complex 1 has a 2D sheet structure through both bridging μO,O′-(NO3) groups and μN,N′-pyrazine moieties. A 3D structure with a characteristic (10,3)-d or 103-utp net is formed through extensive hydrogen bonding. Complex 2 has a 1D chain structure through bridging μN,N′-pyrazine moieties. Strong hydrogen bonds further connect these chains to extend the dimensionality to a 3D network structure. The complexes were tested as corrosion inhibitors for mild steel in 0.1 M nitric acid medium using potentiodynamic polarization technique. Both complexes are of mixed type corrosion inhibitors with dominant anodic effect. The inhibition efficiencies are 68% and 50% for complexes 1 and 2, respectively. The inhibition mechanisms of both inhibitors are mainly due to adsorption of the inhibitor molecules on the surface of mild steel. All data were compared and fitted to the kinetic-thermodynamic model. The binding constants K are 3263 and 1147 for complexes 1 and 2, respectively.
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9.
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10.
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11.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • Synthesis and Structure of Silver Complexes with Nicotinate-Type Ligands Having Antibacterial Activities against Clinically Isolated Antibiotic Resistant Pathogens
  • 2007
  • Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 46:15, s. 5893-5903
  • Tidskriftsartikel (refereegranskat)abstract
    • The synthesis and low-temperature X-ray crystal structures of five new silver complexes, [Ag2-μ-O,O'(2-aminonicotinium)2(NO3)2]n (7), [Ag(isonicotinamide)2-μ-O,O'(NO3)]2 (8), [Ag(ethyl nicotinate)2](NO3) (9), [Ag(ethyl isonicotinate)2(NO3)] (10), and [Ag(methyl isonicotinate)2(H2O)](NO3) (11), are presented and fully characterized by spectral and elemental analysis. The antimicrobial activities of these complexes were screened using 12 different clinical isolates belonging to four pathogenic bacteria, S. aureus, S. pyogenes, P. mirabilis, and Ps. Aeruginosa, all obtained from diabetic foot ulcers. These tested bacteria were resistant for at least 10 antibiotics commonly used for treatment of diabetic foot ulcers. Compounds 7 and 8 had considerable activity against Ps. Aeruginosa (MIC values 2-8 µg/mL), compound 9 against S. aureus (MIC 4-16 µg/mL) and S. pyogenes (MIC 2-4 µg/mL), and also 9 and 11 against P. mirabilis (MIC 1-16 µg/mL). All complexes were non-toxic for daphnia at concentrations above 512 µg/mL overnight.
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12.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • 2D Bipyrimidine silver(I) nitrate: Synthesis, X-ray structure, solution chemistry and anti-microbial activit
  • 2011
  • Ingår i: Inorganic Chemistry Communication. - : Elsevier BV. - 1387-7003. ; 14:4, s. 550-553
  • Tidskriftsartikel (refereegranskat)abstract
    • Synthesis and X-ray single crystal structure analysis of the compound {[Ag2(μ2-bpym)(μ-O-NO3)2]}n, (1), (where bpym = 2,2′-bipyrimidine) are presented. Compound (1) has a (6,3)-2D honeycomb structure with a tetrahedral coordination geometry around the Ag(I) ion. In contrary to the solid state structural investigation, ESI-MS for (1) in solution shows a strong peak at m/z 423.0269 which indicates that the [Ag(bpym)2]+ cation is dominating instead of [Ag2(bpym)]2+. The anti-microbial activity of (1) was screened against 15 multi-drug resistant bacteria in comparison to silver(I) sulphadiazine and it showed a high activity against Burkholderia mallei which causes glanders; with a MIC value of 4 μg/ml.
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13.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening
  • 2011
  • Ingår i: New Journal of Chemistry. - : Royal Society of Chemistry (RSC). - 1369-9261 .- 1144-0546. ; 35:3, s. 640-648
  • Tidskriftsartikel (refereegranskat)abstract
    • Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)2NO3], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)2]NO3 . H2O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)o. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0o. Compound I was characterized by 1H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml-1, respectively). Three different hydrogels containing I or Ag2SO4 were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself.
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14.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • Bis[4-(dimethylamino)pyridine-κN1]silver(I) nitrate dihydrate
  • 2009
  • Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; C65:9, s. m352-m354
  • Tidskriftsartikel (refereegranskat)abstract
    • The title compound, [Ag(C7H10N2)2]NO3·2H2O or [Ag(dmap)2]NO3·2H2O, where dmap is 4-(dimethylamino)pyridine, has a distorted linear coordination geometry around the AgI ion. A novel pattern of water-nitrate hydrogen-bonded anionic strands is formed in the c direction, with the cationic [Ag(dmap)2]+ monomers trapped between them. The AgI ion and the nitrate group atoms, as well as the water molecules (including the H atoms), are on a crystallographic mirror plane (Wyckoff position 4a). The influence of bulky methyl substituents in position 4 of the 4-(dimethylamino)pyridine ligand on packing is discussed. The absolute structure was determined unequivocally.
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15.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • Effects of Different Substituents on the Crystal Structures and Antimicrobial Activities of Six Ag(I) Quinoline Compounds
  • 2013
  • Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 52:7, s. 4046-4060
  • Tidskriftsartikel (refereegranskat)abstract
    • The syntheses and single crystal X-ray structures of [Ag(5-nitroquinoline)(2)]NO3 (1), [Ag(8-nitroquinoline)(2)]NO3 center dot H2O (2), [Ag(6-methoxy-8-nitroquinoline)(NO3)](n) (3), [Ag(3-quinolinecarbonitrile)(NO3)](n) (4), [Ag(3-quinolinecarbonitrile)(2)]NO3 (5), and [Ag(6-quinolinecarboxylic acid)(2)]NO3 (6) are described. As an alternative to solution chemistry, solid-state grinding could be used to prepare compounds 1 and 3, but the preparation of 4 and 5 in this way failed. The Ag(I) ions in the monomeric compounds 1, 2, 5, and 6 are coordinated to two ligands via the nitrogen atoms of the quinoline rings, thereby forming a distorted linear coordination geometry with Ag-N bond distances of 2.142(2)-2.336(2) angstrom and N-Ag-N bond angles of 163.62(13)degrees-172.25(13)degrees. The 1D coordination polymers 3 and 4 contain Ag(I) centers coordinating one ligand and two bridging nitrate groups, thereby forming a distorted trigonal planar coordination geometry with Ag-N bond distances of 2.2700(14) and 2.224(5) angstrom, Ag-O bond distances of 2.261(4)-2.536(5) angstrom, and N-Ag-O bond angles of 115.23(5)degrees-155.56(5)degrees. Hirshfeld surface analyses of compounds 1-6 are presented as d(norm) and curvedness maps. The d(norm) maps show different interaction sites around the Ag(I) ions, i.e., Ag center dot center dot center dot Ag interactions and possible O-H center dot center dot center dot O, C-H center dot center dot center dot O, C-H center dot center dot center dot N, and C-H center dot center dot center dot C hydrogen bonds. Curvedness maps are a good way of visualizing pi-pi tacking interactions between molecules. The antimicrobial activities of compounds 1, 2, and 6 were screened against 15 different multidrug-resistant strains of bacteria isolated from diabetic foot ulcers and compared to the antimicrobial activities of the clinically used silver sulfadiazine (SS). Compound 2 showed activity similar to SS against this set of test organisms, being active against all strains and having slightly better average silver efficiency than SS (5 vs 6 mu g Ag/mL). Against the standard nonresistant bacterial strains of Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, and Streptococcus pyogenes, compound 1 performed better than silver nitrate, with an average MIC of 6 mu g Ag/mL versus 18 mu g Ag/mL for the reference AgNO3. Electrospray ionization mass spectrometry (ESI-MS) analyses of compounds 3 and 6 in DMSO/MeOH confirm the two-coordinated Ag+ complexes in solution, and the results of the H-1 NMR titrations of DMSO solutions of 5-nitroquinoline and 8-nitroquinoline with AgNO3 in DMSO suggest that 5-nitroquinoline is more strongly coordinated to the silver ion.
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16.
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17.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • The coordination polymer poly[(μ3-3-aminocarbonylpyrazine-2-carboxylato-κ3N1:O2:O2')silver(I)]
  • 2011
  • Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; C67:1, s. m1-m4
  • Tidskriftsartikel (refereegranskat)abstract
    • The title compound, [Ag(C6H4N3O3)]n or [Ag(pyzca)]n (where pyzca is 3-aminocarbonylpyrazine-2-carboxylate), (I), was obtained by silver-catalysed partial hydrolysis of pyrazine-2,3-dicarbonitrile in aqueous solution. The compound has a distorted trigonal-planar coordination geometry around the AgI ion, with each ligand bridging three AgI ions to form a one-dimensional strand of molecules parallel to the b axis. An extensive hydrogen-bond pattern connects these strands to form a three-dimensional network of mog topology.
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18.
  • Massoud, Al-Shimaà A A, 1980, et al. (författare)
  • Two 2-D copper(II) azido compounds: catena-poly[di-μ1,1- azido,di-μN,O-(quinolinecarboxylato)(aqua)copper(II)] and 1-D catena-poly[di-μN,N'-(quinoxaline)copper(II)nitrate]
  • 2009
  • Ingår i: Journal of Coordination Chemistry. - : Informa UK Limited. - 0095-8972 .- 1029-0389. ; 62:4, s. 519-530
  • Tidskriftsartikel (refereegranskat)abstract
    • We synthesized three copper(II) complexes with two structurally related polydentate ligands,quinoline-4-carboxylic acid (quCOOH) and quinoxaline (qux). The structures of these complexes were determined using X-ray single crystal crystallography. Complex 1,[Cu(quCOO)(N3)(H2O)]n, has a 2-D polymeric structure through di-μ1,1 azido groups forming (Cu2N2) dimeric units and di-μN,O quinoline carboxylate bridging the binuclear copper units.[Cu(quCOO)(N3)(H2O)]n . 0.87MeOH, (2), has the same structure as 1 in addition to MeOH molecules separating the 2-D sheets of [Cu(quCOO)(N3)(H2O)]n. [Cu(qux)(NO3)2]n, (3), has nocoordinated azido groups, but the quinoxaline is a bidentate bridging ligand giving a 1-D chain,while the μO,O' chelating nitrato groups stabilize the chain structure by forming a square planarcoordination sphere around copper. IR and UV–Vis spectra of the complexes are in agreementwith the crystal structures.
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19.
  • Mautner, F. A., et al. (författare)
  • 1D and 3D coordination polymers with the M(mu(1),mu(1)-X)(2)M motif (M = Na, Zn, Cd): Observation of a linear [Na(H2O)(4)](n)(n+) cation and a five-connected sqp-net
  • 2007
  • Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 26:12, s. 2703-2712
  • Tidskriftsartikel (refereegranskat)abstract
    • Three polymeric complexes [Zn(pydz)(N-3)(SO4)](n)[Na(H2O)(4)](n)(H2O)(4n) (1), [Cd(3-ampy)(N-3)Cl](n) (2), and [Cd(DENA)Cl-2(H2O)](n)(3), (pydz = pyridazine or 1,2-diazine, 3-ampy = 3-aminopyridine, DENA = NN-diethylnicotineamide) have been synthesized and characterized by spectral and structural methods and their network topologies analysed. Complex 1 crystallizes in monoclinic C-centred space group C2/m, the Zn(1) center is octahedrally coordinated; and simultaneously bridged by EO-azido, NN'-pydz, and O,O'-sulphato ligands. The ZnN4O2-octahedra form a ID anionic chain along b-axis. The Na(OH2)(6)-octahedra have also common water molecules, thus also forming a 1D chain along b-axis. The cationic and anionic chains are connected via hydrogen bonds of type O-H...O including lattice water molecules to form a supramolecular 3D network structure. In complex 2, the Cd(1) is six-coordinated by two EE-bridging azide groups, and two nitrogen atoms of bridging NN', 3-ampy ligand, and two bridging chloro ligands. The three different bridging ligands connect the distorted octahedra of the Cd(II) centres to form a 3D network structure with the topology of a square pyramidal net (4(3) (.) 6(6)-sqp). The centrosymmetric Cd2Cl2-rings are planar and the NH2- of the 3-ampy groups forms additional hydrogen bonds of type N-H...N to the adjacent azido groups. In complex 3, the octahedrally coordinated Cd(1) centres are occupied by alternating monodentate DENA ligand and a water molecule and the other four sites are occupied by four bridging chloro ligands. Thus the Cd2Cl2-rings form common edges to form 1D chains of Cd(II) octahedra along the b-axis of the monoclinic unit cell. 2D supramolecular sheets extended along the bc-planes of the unit cell are formed by the 0-H...O hydrogen bond. The IR spectra of the three complexes were measured and they confirm the X-ray structural data. (C) 2007 Elsevier Ltd. All rights reserved.
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20.
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21.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • 1D and 2D FeII Azide Coordination Polymers with Ferromagnetic Canting
  • 2008
  • Ingår i: European Journal of Inorganic Chemistry. - : Wiley. - 1434-1948 .- 1099-0682. ; 2008:1, s. 112-118
  • Tidskriftsartikel (refereegranskat)abstract
    • The two compounds [FeII(pyridine)2(N3)2(H2O)] (1) and [FeII(4-acetylpyridine)2(N3)2] (2) were prepared. The X-ray crystal structures show end-to-end (EE) bridging azides in both cases with a 1D Fe-NNN-Fe chain for 1 and a 2D Fe-NNN-Fe net in 2. Both compounds show similar magnetic behaviour where the high-temperature data are consistent with antiferromagnetic couplings and the low-temperature data indicate ferrimagnetic ordering based on spin canting at 20 and 45 K. Compound 2 also shows a hysteresis loop. These findings are compared to the related 3D coordination polymer [Fe(N3)2(4,4'-bipyridine)]. According to network analyses the latter compound was shown to contain the new uninodal six-connected-network topology (510 · 64 · 7)-jsm.
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22.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • Synthesis, Crystal Structure, Quantum Chemical Calculations, DNA Interactions, and Antimicrobial Activity of [Ag(2-amino-3-methylpyridine)2]NO3 and [Ag(pyridine-2-carboxaldoxime)NO3]
  • 2010
  • Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 49:21, s. 9788-9797
  • Tidskriftsartikel (refereegranskat)abstract
    • [Ag(2-amino-3-methylpyridine)2]NO3 (1) and [Ag(pyridine-2-carboxaldoxime)NO3] (2) were prepared from corresponding ligands and AgNO3 in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2-carboxaldoxime)]+ ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea, M. lutea, and S. aureus and against the yeast Candida albicans, while 2-amino-3-methylpyridine is slightly active and pyridine-2-carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change.
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23.
  • El-Sayed, Ashraf S. A., et al. (författare)
  • Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects
  • 2020
  • Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 25:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible polymers, is the challenge. Four fungal isolates, namely, Aspergillus flavipes, A. terreus, A. flavus, and A. parasiticus, were selected from our previous study as potential Taxol producers, and their potency for Taxol production was evaluated in response to fluconazole and silver nitrate. A higher Taxol yield was reported in the cultures of A. flavipes (185 mu g/L) and A. terreus (66 mu g/L). With addition of fluconazole, the yield of Taxol was increased 1.8 and 1.2-fold for A. flavipes and A. terreus, respectively, confirming the inhibition of sterol biosynthesis and redirecting the geranyl phosphate pool to terpenoids synthesis. A significant inhibition of ergosterol biosynthesis by A. flavipes with addition of fluconazole was observed, correlating with the increase on Taxol yield. To increase the Taxol solubility and to reduce its cytotoxicity, Taxol was modified via chemical conjugation with porphyrin, and the degree of conjugation was checked from the Thin layer chromatography and UV spectral analysis. The antiproliferative activity of native and modified Taxol conjugates was evaluated; upon porphyrin conjugation, the activity of Taxol towards HepG2 was increased 1.5-fold, while its cytotoxicity to VERO cells was reduced 3-fold.
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24.
  • El-Sayed, Ashraf S. A., et al. (författare)
  • Purification and biochemical characterization of taxadiene synthase from bacillus koreensis and stenotrophomonas maltophilia
  • 2021
  • Ingår i: Scientia pharmaceutica. - : MDPI. - 0036-8709 .- 2218-0532. ; 89:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possible that silencing the expression of TDS is the most noticeable genomic feature associated with Taxol-biosynthetic abolishing in fungi. As such, the characterization of TDS with unique biochemical properties and autonomous expression that is independent of transcriptional factors from the host is the main challenge. Thus, the objective of this study was to kinetically characterize TDS from endophytic bacteria isolated from different plants harboring Taxol-producing endophytic fungi. Among the recovered 23 isolates, Bacillus koreensis and Stenotrophomonas maltophilia achieved the highest TDS activity. Upon using the Plackett–Burman design, the TDS productivity achieved by B. koreensis (18.1 µmol/mg/min) and S. maltophilia (14.6 µmol/mg/min) increased by ~2.2-fold over the control. The enzyme was purified by gel-filtration and ion-exchange chromatography with ~15 overall folds and with molecular subunit structure 65 and 80 kDa from B. koreensis and S. maltophilia, respectively. The chemical identity of taxadiene was authenticated from the GC-MS analyses, which provided the same mass fragmentation pattern of authentic taxadiene. The tds gene was screened by PCR with nested primers of the conservative active site domains, and the amplicons were sequenced, displaying a higher similarity with tds from T. baccata and T. brevifolia. The highest TDS activity by both bacterial isolates was recorded at 37–40 °C. The Apo-TDSs retained ~50% of its initial holoenzyme activities, ensuring their metalloproteinic identity. The activity of purified TDS was completely restored upon the addition of Mg2+, confirming the identity of Mg2+ as a cofactor. The TDS activity was dramatically reduced upon the addition of DTNB and MBTH, ensuring the implementation of cysteine-reactive thiols and ammonia groups on their active site domains. This is the first report exploring the autonomous robust expression TDS from B. koreensis and S. maltophilia with a higher affinity to cyclize GGPP into taxadiene, which could be a novel platform for taxadiene production as intermediary metabolites of Taxol biosynthesis.
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25.
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26.
  • Shaheen, H. I., et al. (författare)
  • Phenotypic profiles of enterotoxigenic Escherichia coli associated with early childhood diarrhea in rural Egypt
  • 2004
  • Ingår i: J Clin Microbiol. ; 42:12, s. 5588-95
  • Tidskriftsartikel (refereegranskat)abstract
    • Enterotoxigenic Escherichia coli (ETEC) causes substantial diarrheal morbidity and mortality in young children in countries with limited resources. We determined the phenotypic profiles of 915 ETEC diarrheal isolates derived from Egyptian children under 3 years of age who participated in a 3-year population-based study. For each strain, we ascertained enterotoxin and colonization factor (CF) expression, the O:H serotype, and antimicrobial susceptibility. Sixty-one percent of the strains expressed heat-stable enterotoxin (ST) only, 26% expressed heat-labile enterotoxin (LT) alone, and 12% expressed both toxins. The most common CF phenotypes were colonization factor antigen I (CFA/I) (10%), coli surface antigen 6 (CS6) (9%), CS14 (6%), and CS1 plus CS3 (4%). Fifty-nine percent of the strains did not express any of the 12 CFs included in our test panel. Resistance of ETEC strains to ampicillin (63%), trimethoprim-sulfamethoxazole (52%), and tetracycline (43%) was common, while resistance to quinolone antibiotics was rarely detected. As for the distribution of observed serotypes, there was an unusually wide diversity of O antigens and H types represented among the 915 ETEC strains. The most commonly recognized composite ETEC phenotypes were ST CS14 O78:H18 (4%), ST (or LTST) CFA/I O128:H12 (3%), ST CS1+CS3 O6:H16 (2%), and ST CFA/I O153:H45 (1.5%). Temporal plots of diarrheal episodes associated with ETEC strains bearing common composite phenotypes were consistent with discrete community outbreaks either within a single or over successive warm seasons. These data suggest that a proportion of the disease that is endemic to young children in rural Egypt represents the confluence of small epidemics by clonally related ETEC strains that are transiently introduced or that persist in a community reservoir.
  •  
27.
  • Soliman, S.M., et al. (författare)
  • Towards the chemical control of molecular packing: syntheses and crystal structures of three trans-[NiL4(NCS)2] complexes
  • 2014
  • Ingår i: Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. - 2052-5206 .- 2052-5192. ; 70:1, s. 115-125
  • Tidskriftsartikel (refereegranskat)abstract
    • Three nickel(II) isothiocyanato complexes of the formulatrans-[NiL4(NCS)2] (L = ethylisonicotinate, methylisonicotinateand 4-benzoylpyridine) have been prepared: [Ni(ethylisonicotinate)4(NCS)2] (I), [Ni(methylisonicotinate)4(NCS)2](II) and [Ni(4-benzoylpyridine)4(NCS)2] (III). All threecomplexes are monomeric and have a distorted octahedralgeometry around NiII. Despite their apparent molecularsimilarity, the crystal density of (III) (1.454 g cm 3) issignificantly higher than that of (I) and (II) (both1.408 g cm 3), suggesting that the molecular packing is mostefficient in (III). A study of the molecular Hirshfeld surfaces,together with density functional theory (DFT) calculations,provide insights into the origin of the molecular packingfeatures, and it is suggested that the greater crystal density of(III) results from smaller intermolecular electrostatic repulsions.
  •  
28.
  • Abdelrazak Morsy, Mohammad Hamdy, et al. (författare)
  • SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma
  • 2024
  • Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 143:19, s. 1953-1964
  • Tidskriftsartikel (refereegranskat)abstract
    • Sterile alpha motif and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with ara-CTPase activity that confers cytarabine (ara -C) resistance in several hematological malignancies. Targeting SAMHD1's ara-CTPase activity has recently been demonstrated to enhance ara -C ef fi cacy in acute myeloid leukemia. Here, we identify the transcription factor SRY-related HMGbox containing protein 11 (SOX11) as a novel direct binding partner and fi rst known endogenous inhibitor of SAMHD1. SOX11 is aberrantly expressed not only in mantle cell lymphoma (MCL), but also in some Burkitt lymphomas. Coimmunoprecipitation of SOX11 followed by mass spectrometry in MCL cell lines identi fi ed SAMHD1 as the top SOX11 interaction partner, which was validated by proximity ligation assay. In vitro, SAMHD1 bound to the HMG box of SOX11 with low-micromolar af fi nity. In situ crosslinking studies further indicated that SOX11-SAMHD1 binding resulted in a reduced tetramerization of SAMHD1. Functionally, expression of SOX11 inhibited SAMHD1 ara-CTPase activity in a dose-dependent manner resulting in ara -C sensitization in cell lines and in a SOX11-inducible mouse model of MCL. In SOX11-negative MCL, SOX11-mediated ara-CTPase inhibition could be mimicked by adding the recently identi fi ed SAMHD1 inhibitor hydroxyurea. Taken together, our results identify SOX11 as a novel SAMHD1 interaction partner and its fi rst known endogenous inhibitor with potentially important implications for clinical therapy strati fi cation.
  •  
29.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • 1D, 2D and 3D cadmium(II) polymeric complexes with quinoline-4-carboxylato anion, quinazoline and 2,5-dimethylpyrazine
  • 2006
  • Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 25:5, s. 1187-1194
  • Tidskriftsartikel (refereegranskat)abstract
    • Three new cadmium(II) complexes, namely [Cd(Qux)2(H2O)]n (1), [Cd(Quz)2(N3)2]n (2) and [Cd(dmpz)(N3)2]n (3) (Qux = quinoline-4-carboxylato anion, Quz = quinazoline, dmpz = 2,5-dimethylpyrazine), have been synthesized and characterized by spectroscopic and crystallographic methods. The structure of 1 contains CdO6 slightly distorted octahedral geometry around the Cd(II) atoms, axialy coordinated to two bridging water molecules forming the 1D chain and four oxygen atoms from four different μ-O,O′-bridging caboxylato groups of (Qux) in the equatorial plane. The 1D chains are further held together through hydrogen bonds between the μ-aqua molecule and the meta non-coordinated nitrogen atom of the quinoline moiety. In complex 2, two quinazoline ligands are linked to the central Cd(II) ion in a trans position through the meta hetero nitrogen atom and di(EE), (μ1,3-N3) groups and show a two dimensional (2D) topology. In complex 3 the central cadmium(II) atom is simultaneously coordinated to di(EE), (μ1,3-N3) groups (NCdN, 180.0°) forming a sheet structure in the bc plane and further bridging μ-N,N′-dimethylpyrazine ligand in the a-direction (NCdN, 180.0°) giving rise to a 3D network structure. The IR spectra of the three complexes were measured and they confirm the X-ray structural data.
  •  
30.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • A unique example of a high symmetry three- and four-connected hydrogen bonded 3D-network
  • 2006
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; 2006:10, s. 1082-1084
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a three- and four-connected 3D-net based on 4-aminopyridine coordinated to Ag(I) and hydrogen bonded to nitrate with the unusual, high symmetry, topology (83)(86)2-tfa.
  •  
31.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • Global Engagement in Science: The University’s Fourth Mission?
  • 2018
  • Ingår i: Science & Diplomacy. ; 7:2
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, the authors - three scientists and a diplomat, working across multiple continents - intend to impart some of the broad perspective and deep experience they’ve gained over the years as professionals. The diplomat among us, stationed in the Middle East, has played a role in fostering peace in a region long beset by conflict. Drawing from accumulated lessons, we intend to discuss how others can be encouraged to contribute to global science, regardless of their background or national origin. In taking on this challenge, we will share insights from our various tenures as operators of bilateral aid programs, members of international science organizations, and participants in government negotiations and other events featuring the development of global science.
  •  
32.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • Molecular, supramolecular structures combined with hirshfeld and dft studies of centrosymmetric m(Ii)-azido {m=ni(ii), fe(ii) or zn(ii)} complexes of 4-benzoylpyridine
  • 2021
  • Ingår i: Symmetry. - : MDPI AG. - 2073-8994. ; 13:11
  • Tidskriftsartikel (refereegranskat)abstract
    • The supramolecular structures of the three metal (II) azido complexes [Fe(4bzpy)4 (N3 )2 ]; 1, [Ni(4bzpy)4 (N3 )2 ]; 2 and [Zn(4bzpy)2 (N3 )2 ]n; 3 with 4-benzoylpyridine (4bzpy) were presented. All complexes contain hexa-coordinated divalent metal ions with a slightly distorted octahedral MN6 coordination sphere. Complexes 1 and 2 are monomeric with terminal azido groups while 3 is one-dimensional coordination polymer containing azido groups with µ(1,1) and µ(1,3) bridging modes of bonding. Hirshfeld analysis was used to quantitatively determine the different contacts affecting the molecular packing in the studied complexes. The most common interactions are the polar O … H and N … H interactions and the hydrophobic C … H contacts. The charges at the M(II) sites are calculated to be 1.004, 0.847, and 1.147 e for complexes 1–3, respectively. The degree of asymmetry is the highest in the case of the terminal azide in complexes 1 and 2 while was found the lowest in the µ(1,1) and µ(1,3) azide bonding modes in the Zn(II) complex 3. These facts were further explained in terms of atoms in molecules (AIM) topological parameters.
  •  
33.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • New Polymeric Manganese Azide Derivatives with Quinazoline
  • 2005
  • Ingår i: European Journal of Inorganic Chemistry. - 1434-1948 .- 1099-0682. ; 2005:22, s. 4659 - 4664
  • Tidskriftsartikel (refereegranskat)abstract
    • Two new polymeric derivatives of the (azido)MnII system with formula [Mn(H2O)(μ-N3)(N3)(quinaz)2]n (1) and [Mn(μ-N3)2(quinaz)2]n (2) (quinaz = quinazoline) have been structurally and magnetically characterised. Compound 1 crystallises in the triclinic system, space group P-1, and consists of 1D chains with single end-to-end azido bridges. These chains give a two-dimensional supramolecular arrangement by means of H-bond interactions. Compound 2 crystallises in the monoclinic system, space group C2/c, and contains a square alternating 2D network bridged by azido ligands in the end-to-end coordination mode. Compound 2 exhibits some unusual features, such as the unprecedented linear coordination of the azido bridge. Magnetic analysis reveals moderate antiferromagnetic coupling, with J values in good agreement with the expected range, as a function of the Mn-N-N bond angles.
  •  
34.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • Synthesis, a case of isostructural packing, and antimicrobial activity of silver(I)quinoxaline nitrate, silver(I)(2,5-dimethylpyrazine) nitrate and two related silver aminopyridine compounds
  • 2006
  • Ingår i: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; 2006:21, s. 2542-2550
  • Tidskriftsartikel (refereegranskat)abstract
    • The synthesis and low temperature crystal structures of [Ag(quinoxaline)]n(NO3)n, 1, [Ag(2,5-dimethylpyrazine)(NO3)]n, 2 and [Ag4(3-aminopyridine)4(NO3)4]n 3 are presented. The quinoxaline compound forms a 1D coordination polymer with the characteristic linear 2-coordination figure of silver(I), the NAgN angle being 164.2(1)°, and only weak silvernitrate interactions. In addition there is an interaction giving pairs of parallel chains as the main structural theme. The 2,5-dimethylpyrazine compound has approximately trigonal-planar coordination, also binding one nitrate at the relatively short AgO distances 2.444(3)Å and 2.484(3)Å, respectively, for the two crystallographically different silver atoms. This also results in a 1D coordination polymer that, despite the large differences in the Ag(I) coordination environment, is isostructural with 1. [Ag4(3-aminopyridine)4(NO3)4]n 3 forms a 2D coordination polymer by bridging nitrate ions. The antimicrobial activity of 13, and also of [Ag3(2-aminopyridine)4](NO3)3, 4 was screened for 13 different pathogens and substantial activity was shown for 1 against Escherichia coli and Pseudomonas aeruginosa (MIC 4 µg cm3) and somewhat lower activity was registered against Sarcina lutea and Salmonella typhi for 1, Bordetella bronchiseptica for 2, Salmonella typhi and Pseudomonas aeruginosa for 3, and Escherichia coli and Shigella sonnie for 3 (MIC 8 µg cm3). Only low activity was shown against the yeast Candida albicans for 1, 2 and 4 whereas no activity against this pathogen was registered for 3.
  •  
35.
  • Abu-Youssef, Morsy A.M., et al. (författare)
  • Synthesis, Structure, and Magnetic Behavior of Two New 1D Polymeric Manganese Azido Complexes
  • 2006
  • Ingår i: European Journal of Inorganic Chemistry. ; 2006:16, s. 3177-3184
  • Tidskriftsartikel (refereegranskat)abstract
    • Two new MnII one-dimensional compounds with formulae [Mn(μ-N3)2(pyzamid)2]n (1) and [Mn2(3-ampy)4(μ-N3)2(N3)2(H2O)2]n, (2) (pyzamid = pyrazineamide and 3-ampy = 3-aminopyridine) were structurally and magnetically characterized. Compound 1 crystallizes in the monoclinic system, P2/c space group, and polymerizes through double end-on azido bridges giving 1D chains with the MnII atoms in a MnN6 environment. Compound 2 crystallizes in the triclinic system, P-1 space group, and consists of alternate [Mn(3-ampy)2(μ-N3)2(N3)2] and [Mn(3-ampy)2(μ-N3)2(H2O)2] octahedrons (MnN6 - MnN4O2 environments), linked by single end-to-end azido bridges. Both chains show very uncommon topologies. Attemps to obtain manganese/azido derivatives with the qux = quinoline-4-carboxylato anion gave the recently reported compound [Mn(μ-qux)2(μ-H2O)]n (3), which consists of a chain with only carboxylato and aqua bridges with the MnII atoms in a MnO6 slightly distorted octahedron. In good agreement with the expected behavior, magnetic susceptibility measurements show weak ferromagnetic interactions for 1, whereas compound 2 exhibits moderate antiferromagnetic coupling.
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36.
  • Abu-Youssef, Morsy A. M., et al. (författare)
  • Topology Analysis Reveals Supramolecular Organisation of 96 Large Complex Ions into one Geometrical Object
  • 2016
  • Ingår i: CrystEngComm. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 18:11, s. 1883-1886
  • Tidskriftsartikel (refereegranskat)abstract
    • It is shown that the highly complex crystal structure of [Ag(4-(pyrrolidin-1-yl)pyridine)2]NO3·1/2H2O, 1, with 12 symmetry-independent Ag+ ions and 96 units of complex ions in a unit cell can be understood by the ubiquitous srs topology, reducing thousands of atom positions into a single geometrical object in one go.
  •  
37.
  • Ghazzali, Mohamed I D M, 1974, et al. (författare)
  • 4,4'-(Azinodimethylene)dipyridinium bis(tetrafluoroborate) and 4-[(4-pyridylmethylene)hydrazonomethyl]pyridinium perchlorate: two different hydrogen-bonding motifs
  • 2007
  • Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; C63:5, s. o312-o314
  • Tidskriftsartikel (refereegranskat)abstract
    • In the crystal structures of the title compounds, C12H12N42+·2BF4-, (I), and C12H11N4+·ClO4-, (II), respectively, infinite two- and one-dimensional architectures are built up via N-H...F [in (I)] and conventional N-H...N [in (II)] hydrogen bonding. The N-N single bond in (I) lies on a crystallographic centre of symmetry; as a result, the two pyridinium rings are parallel. In (II), the pyridinium and pyridyl ring planes are inclined with a dihedral angle of 14.45(3)°.
  •  
38.
  • Ghazzali, Mohamed I D M, 1974, et al. (författare)
  • catena-Poly[[chloro(pyridinium-3-carboxylato-κO)zinc(II)]-μ-nicotinato-κ2O:N]
  • 2007
  • Ingår i: Acta Crystallographica Section E: Structure Reports Online. - 1600-5368. ; E63:1, s. m114-m116
  • Tidskriftsartikel (refereegranskat)abstract
    • The title bis-nicotinate zinc chloride, [Zn(C6H4NO2)Cl(C6H5NO2)]n, has an infinite head-to-tail one-dimensional chain structure. The compound was synthesized under mild hydrothermal conditions. The ZnII atom exhibits a distorted tetrahedral coordination geometry. The structure is statistically disordered, with 0.5 site occupancy for the Zn atom and the H atom located on the pyridine N atom. As a result, Zn positions in the crystal structure alternate between two sites related by a crystallographic twofold axis and rows of molecules are formed, supported by strong N-H...O hydrogen bonds.
  •  
39.
  • Ghazzali, Mohamed I D M, 1974, et al. (författare)
  • Synthesis, EPR and DFT calculations of rare Ag(II)porphyrins and the crystal structure of [Zn(II)tetrakis(4-bromo-2-thiophene)porphyrin]
  • 2008
  • Ingår i: Inorganic Chemistry Communication. - : Elsevier BV. - 1387-7003 .- 1879-0259. ; 11:9, s. 1019-1022
  • Tidskriftsartikel (refereegranskat)abstract
    • Meso-tetrakis (4-bromo-2-thiophene) and (5-bromo-2-thiophene) porphyrins were synthesized in 18% yield from freshly distilled pyrrole and the corresponding aldehydes in refluxing propionic acid. Reaction of both porphyrins with either Zn(OAc) 2 · 2H 2 O or Ag(OAc) afforded the corresponding metal complexes in 20% yield. The free bases and metal complexes were characterized by IR, NMR, EPR, MS and XPS. The crystal structure of 5,10,15,20(4-bromo-2-thiophene)porphyrinato Zn(II) was determined by X-ray diffraction and shows a 'zigzag-like' packing pattern due to S···S intermolecular interaction. Structural features of these molecules are discussed by DFT quantum chemical calculations. © 2008 Elsevier B.V. All rights reserved.
  •  
40.
  • Merrien, Magali, et al. (författare)
  • Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
  • 2022
  • Ingår i: Virchows Archiv. - : Springer Science and Business Media LLC. - 0945-6317 .- 1432-2307. ; 480:3, s. 655-666
  • Tidskriftsartikel (refereegranskat)abstract
    • SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment before autologous stem cell transplantation for younger patients with mantle cell lymphoma (MCL). We here investigated the expression of SAMHD1 in a population-based cohort of MCL (N = 150). SAMHD1 was highly variably expressed in MCL (range, 0.4% to 100% of positive tumor cells). Cases with blastoid/pleomorphic morphology had higher SAMHD1 expression (P = 0.028) and SAMHD1 was also correlated to tumor cell proliferation (P = 0.016). SAMHD1 expression showed moderate correlation to the expression of the transcriptional regulator SOX11 (P = 0.036) but genetic silencing of SOX11 and SAMHD1 by siRNA in MCL cell lines did not suggest mutual regulation. We hypothesized that expression of SAMHD1 could predict short time to progression in patients treated with Cytarabine as part of high-dose chemotherapy. Despite the correlation with known biological adverse prognostic factors, neither low or high SAMHD1 expression correlated to PFS or OS in patients treated according to the Nordic MCL2 or MCL3 protocols (N = 158).
  •  
41.
  • Yousri, Amal, et al. (författare)
  • A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity
  • 2023
  • Ingår i: Crystals. - 2073-4352. ; 13:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The pincer ligand 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (bpmt) was used to synthesize the novel [Na(bpmt)(2)][AuCl4] complex through the self-assembly method. In this complex, the Na(I) ion is hexa-coordinated with two tridentate N-pincer ligands (bpmt). The two bpmt ligand units are meridionally coordinated to Na(I) via one short Na-N(s-triazine) and two slightly longer Na-N-(pyrazole) bonds, resulting in a distorted octahedral geometry around the Na(I) ion. In the coordinated bpmt ligand, the s-triazine core is not found to be coplanar with the two pyrazole moieties. Additionally, the two bpmt units are strongly twisted from one another by 64.94 & DEG;. Based on Hirshfeld investigations, the H & BULL;& BULL;& BULL;H (53.4%) interactions have a significant role in controlling the supramolecular arrangement of the [Na(bpmt)(2)][AuCl4] complex. In addition, the Cl & BULL;& BULL;& BULL;H (12.2%), C & BULL;& BULL;& BULL;H (11.5%), N & BULL;& BULL;& BULL;H (9.3%), and O & BULL;& BULL;& BULL;H (4.9%) interactions are significant. Antimicrobial investigations revealed that the [Na(bpmt)(2)][AuCl4] complex has promising antibacterial and antifungal activities. The [Na(bpmt)(2)][AuCl4] complex showed enhanced antibacterial activity for the majority of the studied gram-positive and gram-negative bacteria compared to the free bpmt (MIC = 62.5-125 & mu;g/mL vs. MIC = 62.5-500 & mu;g/mL, respectively) and Amoxicillin (MIC > 500 & mu;g/mL) as a positive control. Additionally, the [Na(bpmt)(2)][AuCl4] complex had better antifungal efficacy (MIC = 125 & mu;g/mL) against C. albicans compared to bpmt (MIC = 500 & mu;g/mL).
  •  
42.
  • Yousri, Amal, et al. (författare)
  • Synthesis, structure diversity, and antimicrobial studies of Ag(i) complexes with quinoline-type ligands
  • 2023
  • Ingår i: CrystEngComm. - 1466-8033. ; 25:27, s. 3922-3930
  • Tidskriftsartikel (refereegranskat)abstract
    • Compounds [Ag(5NO2Qu)2]BF4 (1) and [Ag(Qu3CN)(H2O)]BF4 (2) were prepared and studied from a structural perspective and screened for antimicrobial activity. The Ag(i) in the monomeric complex 1 is coordinated to two 5-nitroquinoline (5NO2Qu) ligands via the N-atoms of the quinoline rings with equidistant Ag-N bonds (2.146(2) Å) and a N-Ag-N# bond angle of 171.42(8)°. The 2D coordination polymer 2 contains tetracoordinated Ag(i) with two N-atoms (N1 and N2#1) from two quinoline-3-carbonitrile (Qu3CN) ligands and two O-atoms (O1 and O1#1) from two water molecules. The Qu3CN ligand acts as a connector between the Ag(i) sites along the b-direction via two short Ag1-N1 (2.185(4) Å) and Ag1-N2#1 (2.204(4) Å) bonds. In addition, the Ag(i) is coordinated with two symmetry related water molecules which are also acting as connectors between the Ag(i) sites along the a-direction via two longer Ag1-O1 (2.470(4) Å) and Ag1-O1#2 (2.546(4) Å) bonds. Hirshfeld surface analysis confirmed the significance of the polar F⋯H contacts in the molecular packing of 1 (25.9%) and 2 (39.9%). In addition, the crystal packing of 1 showed a significant amount of polar O⋯H (23.5%) contacts. Also, both complexes displayed π-π stacking interactions. The Ag(i) complexes and the free ligand were assessed for their antimicrobial activities. It was found that 1 (MIC = 7.8 μg mL−1) and 2 (MIC = 31.25 μg mL−1) have higher antifungal potency against C. albicans than their free ligands (MIC = 125 μg mL−1). Interestingly, 1 has better antifungal activity than the standard nystatin (15.6 μg mL−1). Also, both Ag(i) complexes and the free ligands as well have better activity against P. mirabilis than the common antibiotic amoxicillin.
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