| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 3. |
- Barack, Leor, et al.
(författare)
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Black holes, gravitational waves and fundamental physics : a roadmap
- 2019
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Ingår i: Classical and quantum gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 36:14
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Forskningsöversikt (refereegranskat)abstract
- The grand challenges of contemporary fundamental physics dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress. This write-up is an initiative taken within the framework of the European Action on 'Black holes, Gravitational waves and Fundamental Physics'.
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| 4. |
- Sandholm, Niina, et al.
(författare)
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New susceptibility loci associated with kidney disease in type 1 diabetes
- 2012
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Ingår i: PLOS Genetics. - San Francisco, USA : Public Library of Science, PLOS. - 1553-7390 .- 1553-7404. ; 8:9, s. e1002921-
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Tidskriftsartikel (refereegranskat)abstract
- Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a pivotal role in DN, a subset of individuals with poorly controlled T1D do not develop DN. Furthermore, strong familial aggregation supports genetic susceptibility to DN. However, the genes and the molecular mechanisms behind the disease remain poorly understood, and current therapeutic strategies rarely result in reversal of DN. In the GEnetics of Nephropathy: an International Effort (GENIE) consortium, we have undertaken a meta-analysis of genomewide association studies (GWAS) of T1D DN comprising similar to 2.4 million single nucleotide polymorphisms (SNPs) imputed in 6,691 individuals. After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 x 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 x 10(-9)). Functional data suggest that AFF3 influences renal tubule fibrosis via the transforming growth factor-beta (TGF-beta 1) pathway. The strongest association with DN as a primary phenotype was seen for an intronic SNP in the ERBB4 gene (rs7588550, P = 2.1 x 10(-7)), a gene with type 2 diabetes DN differential expression and in the same intron as a variant with cis-eQTL expression of ERBB4. All these detected associations represent new signals in the pathogenesis of DN.
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| 5. |
- Allentoft, Morten E., et al.
(författare)
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Population genomics of post-glacial western Eurasia
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 301-311
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Tidskriftsartikel (refereegranskat)abstract
- Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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| 6. |
- Søgaard Jørgensen, Peter, et al.
(författare)
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Antibiotic and pesticide susceptibility and the Anthropocene operating space
- 2018
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Ingår i: Nature Sustainability. - : Springer Science and Business Media LLC. - 2398-9629. ; 1:11, s. 632-641
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Forskningsöversikt (refereegranskat)abstract
- Rising levels of antimicrobial and pesticide resistance increasingly undermine human health and systems for biomass production, and emphasize the sustainability challenge of preserving organisms susceptible to these biocides. In this Review, we introduce key concepts and examine dynamics of biocide susceptibility that must be governed to address this challenge. We focus on the impact of biocides on the capacity of susceptible organisms to prevent spread of resistance, and we then review how biocide use affects a broader suite of ecosystem services. Finally, we introduce and assess the state of what we term the Anthropocene operating space of biocide susceptibility, a framework for assessing the potential of antibiotic and pesticide resistance to undermine key functions of human society. Based on current trends in antibiotic, insecticide and herbicide resistance, we conclude that the states of all six assessed variables are beyond safe zones, with three variables surpassed regionally or globally.
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| 7. |
- Søgaard Jørgensen, Peter, et al.
(författare)
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Coevolutionary Governance of Antibiotic and Pesticide Resistance
- 2020
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Ingår i: Trends in Ecology & Evolution. - : Elsevier BV. - 0169-5347 .- 1872-8383. ; 35:6, s. 484-494
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Forskningsöversikt (refereegranskat)abstract
- Development of new biocides has dominated human responses to evolution of antibiotic and pesticide resistance. Increasing and uniform biocide use, the spread of resistance genes, and the lack of new classes of compounds indicate the importance of navigating toward more sustainable coevolutionary dynamics between human culture and species that evolve resistance. To inform this challenge, we introduce the concept of coevolutionary governance and propose three priorities for its implementation: (i) new norms and mental models for lowering use, (ii) diversifying practices to reduce directional selection, and (iii) investment in collective action institutions to govern connectivity. We highlight the availability of solutions that facilitate broader sustainable development, which for antibiotic resistance include improved sanitation and hygiene, strong health systems, and decreased meat consumption.
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| 8. |
- Aubert, Salome, et al.
(författare)
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Global Matrix 3.0 Physical Activity Report Card Grades for Children and Youth: Results and Analysis From 49 Countries
- 2018
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Ingår i: Journal of Physical Activity and Health. - : HUMAN KINETICS PUBL INC. - 1543-3080 .- 1543-5474. ; 15, s. S251-S273
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Tidskriftsartikel (refereegranskat)abstract
- Background: Accumulating sufficient moderate to vigorous physical activity is recognized as a key determinant of physical, physiological, developmental, mental, cognitive, and social health among children and youth (aged 5-17 y). The Global Matrix 3.0 of Report Card grades on physical activity was developed to achieve a better understanding of the global variation in child and youth physical activity and associated supports. Methods: Work groups from 49 countries followed harmonized procedures to develop their Report Cards by grading 10 common indicators using the best available data. The participating countries were divided into 3 categories using the United Nations human development index (HDI) classification (low or medium, high, and very high HDI). Results: A total of 490 grades, including 369 letter grades and 121 incomplete grades, were assigned by the 49 work groups. Overall, an average grade of "C-," "D+," and "C-" was obtained for the low and medium HDI countries, high HDI countries, and very high HDI countries, respectively. Conclusions: The present study provides rich new evidence showing that the situation regarding the physical activity of children and youth is a concern worldwide. Strategic public investments to implement effective interventions to increase physical activity opportunities are needed.
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| 9. |
- Aubert, Salome, et al.
(författare)
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Report Card Grades on the Physical Activity of Children and Youth Comparing 30 Very High Human Development Index Countries
- 2018
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Ingår i: Journal of Physical Activity and Health. - : HUMAN KINETICS PUBL INC. - 1543-3080 .- 1543-5474. ; 15, s. S298-S314
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Tidskriftsartikel (refereegranskat)abstract
- Background: To better understand the childhood physical inactivity crisis, Report Cards on physical activity of children and youth were prepared concurrently in 30 very high Human Development Index countries. The aim of this article was to present, describe, and compare the findings from these Report Cards. Methods: The Report Cards were developed using a harmonized process for data gathering, assessing, and assigning grades to 10 common physical activity indicators. Descriptive statistics were calculated after converting letter grades to interval variables, and correlational analyses between the 10 common indicators were performed using Spearmans rank correlation coefficients. Results: A matrix of 300 grades was obtained with substantial variations within and between countries. Low grades were observed for behavioral indicators, and higher grades were observed for sources of influence indicators, indicating a disconnect between supports and desired behaviors. Conclusion: This analysis summarizes the level and context of the physical activity of children and youth among very high Human Development Index countries, and provides additional evidence that the situation regarding physical activity in children and youth is very concerning. Unless a major shift to a more active lifestyle happens soon, a high rate of noncommunicable diseases can be anticipated when this generation of children reaches adulthood.
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| 10. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 11. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 12. |
- Carriere, Yves, et al.
(författare)
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Governing evolution : A socioecological comparison of resistance management for insecticidal transgenic Bt crops among four countries
- 2020
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 49:1, s. 1-16
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Forskningsöversikt (refereegranskat)abstract
- Cooperative management of pest susceptibility to transgenic Bacillus thuringiensis (Bt) crops is pursued worldwide in a variety of forms and to varying degrees of success depending on context. We examine this context using a comparative socioecological analysis of resistance management in Australia, Brazil, India, and the United States. We find that a shared understanding of resistance risks among government regulators, growers, and other actors is critical for effective governance. Furthermore, monitoring of grower compliance with resistance management requirements, surveillance of resistance, and mechanisms to support rapid implementation of remedial actions are essential to achieve desirable outcomes. Mandated resistance management measures, strong coordination between actors, and direct linkages between the group that appraises resistance risks and growers also appear to enhance prospects for effective governance. Our analysis highlights factors that could improve current governance systems and inform other initiatives to conserve susceptibility as a contribution to the cause of public good.
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| 13. |
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| 14. |
- Hagstotz, Steffen, et al.
(författare)
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Breaking cosmic degeneracies : Disentangling neutrinos and modified gravity with kinematic information
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 629
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Tidskriftsartikel (refereegranskat)abstract
- Searches for modified gravity in the large-scale structure try to detect the enhanced amplitude of density fluctuations caused by the fifth force present in many of these theories. Neutrinos, on the other hand, suppress structure growth below their free-streaming length. Both effects take place on comparable scales, and uncertainty in the neutrino mass leads to a degeneracy with modified gravity parameters for probes that are measuring the amplitude of the matter power spectrum. We explore the possibility to break the degeneracy between modified gravity and neutrino effects in the growth of structures by considering kinematic information related to either the growth rate on large scales or the virial velocities inside of collapsed structures. In order to study the degeneracy up to fully non-linear scales, we employ a suite of N-body simulations including both f (R) modified gravity and massive neutrinos. Our results indicate that velocity information provides an excellent tool to distinguish massive neutrinos from modified gravity. Models with different values of neutrino masses and modified gravity parameters possessing a comparable matter power spectrum at a given time have different growth rates. This leaves imprints in the velocity divergence, which is therefore better suited than the amplitude of density fluctuations to tell the models apart. In such models with a power spectrum comparable to ACDM today, the growth rate is strictly enhanced. We also find the velocity dispersion of virialised clusters to be well suited to constrain deviations from general relativity without being affected by the uncertainty in the sum of neutrino masses.
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| 15. |
- Högås, Marcus, 1991-
(författare)
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Was Einstein Wrong? : Theoretical and observational constraints on massive gravity
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- For more than a century, Einstein's theory of general relativity has described gravitational phenomena with astonishing precision. However, for the theory to fit observations we need to add two elusive substances: dark energy and dark matter. Together they add up to 95% of the energy budget of the Universe. Yet, we do not know what these substances are. Another question mark is the expansion rate of the Universe; two incompatible values are obtained depending on the measuring method. These problems (dark energy, dark matter, and the expansion rate) belong to the big questions within gravity today and they may be interpreted as signs that general relativity is not the final theory for gravity. As an alternative, in this thesis we analyze an extended theory of gravity called bimetric gravity. In general relativity (GR), gravity is massless which means that gravitational waves propagate at the speed of light. Hence, a natural extension is to consider theories where gravity has a mass. This is precisely what bimetric gravity achieves. The theoretical consistency of this theory is firmly established but it is also crucial to test if the theory agrees with observations. In fact, in this theory there are two types of gravitational waves/fields, one massless as in GR but also one massive. When observing gravitational phenomena, we observe a mix of the two. Depending on the mixing and on the mass of the massive field, observational signatures appear for example on cosmological scales, in gravitational wave events or on solar-system scales. Until recently the phenomenology of the full theory was still uncharted, and an important question was if all observational tests could be satisfied at the same time. To address this, we devised a unified framework that enables straightforward comparison between constraints from different probes, without being restricted to a particular region of the parameter space. The result is that bimetric gravity is compatible with observations and even fit data slightly better than GR. Together with the fact that the dark energy can be explained by the interaction between the two gravitational fields, we have shown that the theory is a viable dark energy candidate. At the same time, the observational data provides a substantial restriction on the parameter space that excludes many of the popular models in the literature – an important result in and of itself.A longstanding issue within this theory has been to predict the growth of structure while avoiding exponential instabilities. Here, we propose a simple model which solves the full, nonlinear equations of motion, which can be used to calculate the growth of structure, without any instabilities. We also describe our work towards a framework for calculating the process of gravitational collapse in this theory where we manage to solve the equations numerically for a short time interval. The results indicate that the gravitational collapse proceeds as in general relativity, assuming that the initial conditions are similar.Future work is needed to decide whether bimetric gravity can solve any of the other big questions within gravity today, such as the discrepant expansion rate of the Universe. In this thesis, we show that it is an observationally viable dark energy candidate that exhibits novel gravitational features. In short, gravity can be massive.
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| 16. |
- Jaromin, Anna, et al.
(författare)
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Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model.
- 2024
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Ingår i: Antimicrobial Agents and Chemotherapy. - 1098-6596. ; 68:1
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Tidskriftsartikel (refereegranskat)abstract
- The newly emerged pathogen, Candida auris, presents a serious threat to public health worldwide. This multidrug-resistant yeast often colonizes and persists on the skin of patients, can easily spread from person to person, and can cause life-threatening systemic infections. New antifungal therapies are therefore urgently needed to limit and control both superficial and systemic C. auris infections. In this study, we designed a novel antifungal agent, PQA-Az-13, that contains a combination of indazole, pyrrolidine, and arylpiperazine scaffolds substituted with a trifluoromethyl moiety. PQA-Az-13 demonstrated antifungal activity against biofilms of a set of 10 different C. auris clinical isolates, representing all four geographical clades distinguished within this species. This compound showed strong activity, with MIC values between 0.67 and 1.25 µg/mL. Cellular proteomics indicated that PQA-Az-13 partially or completely inhibited numerous enzymatic proteins in C. auris biofilms, particularly those involved in both amino acid biosynthesis and metabolism processes, as well as in general energy-producing processes. Due to its hydrophobic nature and limited aqueous solubility, PQA-Az-13 was encapsulated in cationic liposomes composed of soybean phosphatidylcholine (SPC), 1,2-dioleoyloxy-3-trimethylammonium-propane chloride (DOTAP), and N-(carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl- sn-glycero-3-phosphoethanolamine, sodium salt (DSPE-PEG 2000), and characterized by biophysical and spectral techniques. These PQA-Az-13-loaded liposomes displayed a mean size of 76.4 nm, a positive charge of +45.0 mV, a high encapsulation efficiency of 97.2%, excellent stability, and no toxicity to normal human dermal fibroblasts. PQA-Az-13 liposomes demonstrated enhanced antifungal activity levels against both C. auris in in vitro biofilms and ex vivo skin colonization models. These initial results suggest that molecules like PQA-Az-13 warrant further study and development.
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| 17. |
- Lang, Justin J., et al.
(författare)
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Top 10 International Priorities for Physical Fitness Research and Surveillance Among Children and Adolescents : A Twin-Panel Delphi Study
- 2023
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Ingår i: Sports Medicine. - New Zealand : Adis International Ltd.. - 0112-1642 .- 1179-2035. ; 53:2, s. 549-564
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Tidskriftsartikel (refereegranskat)abstract
- Background The measurement of physical fitness has a history that dates back nearly 200 years. Recently, there has been an increase in international research and surveillance on physical fitness creating a need for setting international priorities that could help guide future efforts. Objective This study aimed to produce a list of the top 10 international priorities for research and surveillance on physical fitness among children and adolescents. Methods Using a twin-panel Delphi method, two independent panels consisting of 46 international experts were identified (panel 1 = 28, panel 2 = 18). The panel participants were asked to list up to five priorities for research or surveillance (round 1), and then rated the items from their own panel on a 5-point Likert scale of importance (round 2). In round 3, experts were asked to rate the priorities identified by the other panel. Results There was strong between-panel agreement (panel 1: r(s) = 0.76, p < 0.01; panel 2: r(s) = 0.77, p < 0.01) in the priorities identified. The list of the final top 10 priorities included (i) "conduct longitudinal studies to assess changes in fitness and associations with health". This was followed by (ii) "use fitness surveillance to inform decision making", and (iii) "implement regular and consistent international/national fitness surveys using common measures". Conclusions The priorities identified in this study provide guidance for future international collaborations and research efforts on the physical fitness of children and adolescents over the next decade and beyond.
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| 18. |
- Li, Dongqing, et al.
(författare)
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Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:19, s. 9443-9452
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Tidskriftsartikel (refereegranskat)abstract
- An increasing number of studies reveal the importance of long noncoding RNAs (lncRNAs) in gene expression control underlying many physiological and pathological processes. However, their role in skin wound healing remains poorly understood. Our study focused on a skin-specific lncRNA, LOC105372576, whose expression was increased during physiological wound healing. In human nonhealing wounds, however, its level was significantly lower compared with normal wounds under reepithelialization. We characterized LOC105372576 as a nuclear-localized, RNAPII-transcribed, and polyadenylated lncRNA. In keratinocytes, its expression was induced by TGF-beta signaling. Knockdown of LOC105372576 and activation of its endogenous transcription, respectively, reduced and increased the motility of keratinocytes and reepithelialization of human ex vivo skin wounds. Therefore, LOC105372576 was termed "wound and keratinocyte migration-associated lncRNA 1" (WAKMAR1). Further study revealed that WAKMAR1 regulated a network of protein-coding genes important for cell migration, most of which were under the control of transcription factor E2F1. Mechanistically, WAKMAR1 enhanced E2F1 expression by interfering with E2F1 promoter methylation through the sequestration of DNA methyltransferases. Collectively, we have identified a lncRNA important for keratinocyte migration, whose deficiency may be involved in the pathogenesis of chronic wounds.
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| 19. |
- Renk, Janina J., 1990-
(författare)
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Delving in the Dark : Searching for Signatures of Non-Standard Physics in Cosmological and Astrophysical Observables
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The dark sectors of our Universe, dark matter and dark energy, together constitute about 96 % of the total energy content of the Universe. To date, we only have observational evidence for their existence. What is still lacking is a complete theoretical framework consistent with all observational data to embed a dark matter particle or component into the standard models of particle physics and cosmology, as well as an explanation for the nature or origin of dark energy.Since the discovery of these dark components decades ago, a variety of different theories have been proposed to overcome the shortcomings of our current standard models. To assess the viability of these non-standard theories, they ideally should be tested against all relevant available datasets. In this thesis, I show two examples of how cosmological and astrophysical observables are used to constrain or even rule out non-standard cosmological models. Further, I present the first software tool that provides a general framework to test non-standard physics with global fits to data from particle physics and cosmology simultaneously.The first example is minimally coupled covariant Galileons, a modification of General Relativity to explain dark energy without the need for a fine-tuned cosmological constant. I demonstrate how the combination of constraints arising from the integrated Sachs-Wolf effect and the propagation speed of gravitational waves can rule out all three branches of the theory.The second example shows how the existence and parameter space of cosmic superstrings can be constrained. These are the hypothesised fundamental building blocks of Type IIb Superstring theory, stretched out to cosmological scales during the phase of inflation. The theory can be tested through the unique microlensing signature of cosmic superstrings when crossing the line of sight of an observer monitoring a point-like source. I show how, based on simulations, we can estimate the expected detection rates from observations of distant Type Ia Supernovae and stars in Andromeda; from these estimates I assess the implications for the theory.Finally, I present CosmoBit, a new module for the Global and Modular Beyond-Standard Model Inference Tool (GAMBIT). \gambit allows the user to test a variety of extensions to the Standard Model of particle physics against data from, e.g. collider searches, dark matter direct and indirect detection experiments, as well as laboratory measurements of neutrino properties. CosmoBit augments this with the inclusion of cosmological likelihoods. This addition opens up the possibility to test a given model against data from, e.g. the Big Bang Nucleosynthesis proceeding minutes after the Big Bang, probes of the Cosmic Microwave Background ~ 380,000 years later, and (laboratory) measurements from the present day, 13.8 billion years after the Big Bang. Including measurements that span several different epochs and orders of magnitude in energy, the combination of CosmoBit with other GAMBIT modules provides a promising tool for shedding light on the dark sectors of the Universe.
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| 20. |
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| 21. |
- Van Den Berg, F. D., et al.
(författare)
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In-line Characterisation of Microstructure and Mechanical Properties in the Manufacturing of Steel Strip for the Purpose of Product Uniformity Control
- 2016
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Ingår i: DGZfP-Proceedings BB 158. - 9783940283788
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Konferensbidrag (refereegranskat)abstract
- The uniformity of the microstructure of steel strip over the entire coil length and between different coils of the same grade is key to stable and consistent material behaviour in steel manufacturers’ proprietary processes, like rolling and levelling, and customers’ processes, like pressing and deep-drawing. In particular for high-strength steels, like dual phase and complex phase steels, the microstructure is very sensitive to processing variations resulting in a potentially larger spread in the mechanical properties of the product. In July 2013, a large European consortium consisting of 15 institutes started an RFCS [1] – funded project called “Product Uniformity Control” (PUC) with the primary objective to achieve enhanced and sustained product uniformity of steel strip by improved interpretation of data from inline measurement methods that aim 2 for real-time and non-destructive characterisation of microstructure and technomechanical parameters. Commonly, these techniques are based on electromagnetic (EM) or ultrasonic (US) measurement principles, which are favoured because of their non-destructive and potentially contact-free nature. To improve the techniques for inline materials characterisation, the PUC consortium takes a systematic approach to investigate the interrelations between mechanical properties -- microstructural parameters -- EM & US properties -- inline measurement thereof. The studies involve dedicated laboratory experiments, modelling of the EM and US properties of steel, modelling of inline measurement setups and statistical analysis of data from inline measurement systems. The synthesis of these activities should result in improved, model-based, calibrations and finally in a broader deployment and integration of the inline material characterisation techniques in steel manufacturing, adding value to the product and enhancing the process efficiency throughout the production chain from hot-rolling to finishing. This paper outlines the project approach, highlights interconnecting modelling and experimental research work, and demonstrates first results. Various contributions being presented at this WCNDT conference originate from the collaborative activities of this PUC project.
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| 22. |
- Volker, A., et al.
(författare)
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Ultrasonic Assessment of Metal Microstructures, Modelling and Validation
- 2016
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Ingår i: DGZfP-Proceedings BB 158, ISBN 978-3-940283-78-8. - 9783940283788
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Konferensbidrag (refereegranskat)abstract
- The uniformity of strip rolled steel and its mechanical properties are intrinsically linked to the complex microstructure along the strip length. Ultrasonic methods are sensitive to differences in grain size, grain distribution and texture. This with the intention to provide suitable tools to inline monitors the properties of hot rolled steel. In this paper, we present a comparison of results from numerical and analytical simulations of the elastic wave propagation in deterministic and stochastic models of the microstructures. Modelled microstructures are used to provide the flexibility of assessing single microstructural parameters of different steel grades and rolling conditions. The individual simulations are validated against laser ultrasonic measurements on metal sheets in thickness range of 2mm-5mm, which were independently characterized metallurgically. The correlation to parameters as texture, grain size and dual phase composition was addressed. The simulation facilitates the development of methodologies to identify quantitative values that will enable to non-destructively assess the quality of a component. Different methods are developed based on changes in attenuation and velocity. These were tested against the simulated as well as the experimental data.
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| 23. |
- Xu, Johanna, 1989, et al.
(författare)
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Effect of tension during stabilization on carbon fiber multifunctionality for structural battery composites
- 2023
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Ingår i: Carbon. - : Elsevier BV. - 0008-6223. ; 209
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Tidskriftsartikel (refereegranskat)abstract
- Here we demonstrate carbon fibers with tailorable multifunctional properties for energy storage composites. Carbon fibers made from the same precursor but with different processing tensions are investigated. The applied tension during the stabilization/oxidation stage of fiber manufacturing determines the microstructure and the resulting mechanical and electrochemical performance. Understanding of the interconnected effects enables tailoring of fibers to function as electrodes in structural battery composites. The study reveals that both amorphous and crystalline phases affect the electrochemical capacity, as higher capacity is achieved by larger d-spacing as well as higher void content. Further, the study confirms the trade-off between high tensile strength and high electrochemical capacity that needs to be taken into consideration when designing multifunctional carbon fibers.
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| 24. |
- Yang, Weiqiang, et al.
(författare)
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Listening to the sound of dark sector interactions with gravitational wave standard sirens
- 2019
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We consider two stable Interacting Dark Matter-Dark Energy models and confront them against current Cosmic Microwave Background data from the Planck satellite. We then generate luminosity distance measurements from O(10(3)) mock Gravitational Wave events matching the expected sensitivity of the proposed Einstein Telescope. We use these to forecast how the addition of Gravitational Wave standard sirens data can improve current limits on the Dark Matter-Dark Energy coupling strength (xi). We find that the addition of Gravitational Waves data can reduce the current uncertainty by a factor of 5. Moreover, if the underlying cosmological model truly features Dark Matter-Dark Energy interactions with a value of xi within the currently allowed 1 sigma upper limit, the addition of Gravitational Wave data would help disentangle such an interaction from the standard case of no interaction at a significance of more than 3 sigma.
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| 25. |
- Yang, Weiqiang, et al.
(författare)
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Tale of stable interacting dark energy, observational signatures, and the H0 tension
- 2018
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :9
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the observational consequences of a novel class of stable interacting dark energy (IDE) models, featuring interactions between dark matter (DM) and dark energy (DE). In the first part of our work, we start by considering two IDE models which are known to present early-time linear perturbation instabilities. Applying a transformation depending on the dark energy equation of state (EoS) to the DM-DE coupling, we then obtain two novel stable IDE models. Subsequently, we derive robust and accurate constraints on the parameters of these models, assuming a constant EoS w(x) for the DE fluid, in light of some of the most recent publicly available cosmological data. These include Cosmic Microwave Background (CMB) temperature and polarization anisotropy measurements from the Planck satellite, a selection of Baryon Acoustic Oscillation measurements, Supernovae Type-Ia luminosity distance measurements from the JLA sample, and measurements of the Hubble parameter up to redshift 2 from cosmic chronometers. Our analysis displays a mild preference for the DE fluid residing in the phantom region (w(x) < -1), with significance up to 95% confidence level, while we obtain new upper limits on the coupling parameter between the dark components. The preference for a phantom DE suggests a coupling function Q < 0, thus a scenario where energy flows from the DE to the DM. We also examine the possibility of addressing the H-0 and sigma(8) tensions, finding that only the former can be partially alleviated. Finally, we perform a Bayesian model comparison analysis to quantify the possible preference for the two IDE models against the standard concordance ACDM model, finding that the latter is always preferred with the strength of the evidence ranging from positive to very strong.
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