| 1. |
- Ali, Irfan, et al.
(författare)
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A thermal-aware scheduling algorithm for reducing thermal risks in DAG-based applications in cyber-physical systems
- 2023
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Ingår i: Ubiquitous security. - Singapore : Springer. - 9789819902712 - 9789819902729 ; , s. 497-508
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Konferensbidrag (refereegranskat)abstract
- Directed Acyclic Graph (DAG)-based scheduling applications are critical to resource allocation in the Cloud, Edge, and Fog layers of cyber-physical systems (CPS). However, thermal anomalies in DVFS-enabled homogeneous multiprocessor systems (HMSS) may be exploited by malicious applications posing risks to the availability of the underlying CPS. This can negatively affect the trustworthiness of CPS. This paper proposes an algorithm to address the thermal risks in DVFS-enabled HMSS for periodic DAG-based applications. It also improves the current list scheduling-based Depth-First and Breadth-First techniques without violating the timing constraints of the system. We test the algorithm using standard benchmarks and synthetic applications in a simulation setup. The results show a reduction in the temperature peaks by up to 30%, average temperature by up to 22%, temperature variations up to 3 times, and temperature spatial gradients by up to 4 times as compared to the conventional Depth-First Scheduling algorithms.
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| 2. |
- Hjort, Line, et al.
(författare)
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Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children
- 2018
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 3:17
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Tidskriftsartikel (refereegranskat)abstract
- Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMethylation450 BeadChip. Pyrosequencing was performed for validation/replication of putative GDM-associated, differentially methylated CpGs in additional 905 offspring (462 GDM, 444 control offspring). We identified 76 differentially methylated CpGs in GDM offspring compared with controls in the discovery cohort (FDR, P < 0.05). Adjusting for offspring BMI did not affect the association between methylation levels and GDM status for any of the 76 CpGs. Most of these epigenetic changes were due to confounding by maternal prepregnancy BMI; however, 13 methylation changes were independently associated with maternal GDM. Three prepregnancy BMI-associated CpGs (cg00992687 and cg09452568 of ESM1 and cg14328641 of MS4A3) were validated in the replication cohort, while cg09109411 (PDE6A) was found to be associated with GDM status. The identified methylation changes may reflect developmental programming of organ disease mechanisms and/or may serve as disease biomarkers.
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| 3. |
- Liu, DJ, et al.
(författare)
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Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
- 2023
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 369-
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1. This recent study—and most other large-scale human genetics studies—was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48; P = 5.4 × 10−6). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes (SRRM2 and AKAP11) were newly implicated as SCZ risk genes, and one gene (PCLO) was identified as shared by individuals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across diverse human populations.
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