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- Bjorklund, K, et al.
(författare)
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Pregnancy-related back and pelvic pain and changes in bone density
- 1999
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Ingår i: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. - : MUNKSGAARD INT PUBL LTD. - 0001-6349. ; 78:8, s. 681-685
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objective. To elucidate whether there is an association between pregnancy-related back and pelvic pain and changes in bone density. Methods. In this prospective cohort study. bone density was measured in the distal and ultradistal forearm at 12 and 35 wee
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- FALKEBORN, M, et al.
(författare)
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Validity of information on gynecological operations in the Swedish in-patient registry
- 1995
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Ingår i: Scandinavian journal of social medicine. - : SAGE Publications. - 0300-8037. ; 23:3, s. 220-224
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Tidskriftsartikel (refereegranskat)abstract
- In order to validate information held at the Swedish Inpatient Registry on oophorectomy and/or hysterectomy procedures, the register codes were compared with data from the medical records in a random sample of 1,338 women. Only 1% of these codes were missing but 5% were erroneous, which in most cases meant that the oophorectomy had been misclassified. The positive predictive value of operation codes was high, ranging from 86 to 100% of the registered events. The actual procedures among women registered with a code for hysterectomy with or without oophorectomy comprised hysterectomy alone in 47% of the women and hysterectomy with a bilateral or unilateral oophorectomy in 30% and 20%, respectively. The reliability of register codes for major gynecological surgical procedures is good, but when the code for hysterectomy is used, medical record data are needed to ascertain the ovarian status. Revised codes are therefore recommended.
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- Naessen, T, et al.
(författare)
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Bone loss in elderly women prevented by ultralow doses of parenteral 17beta-estradiol.
- 1997
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Ingår i: American Journal of Obstetrics and Gynecology. - : Elsevier BV. - 0002-9378 .- 1097-6868. ; 177:1, s. 115-9
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Our purpose was to assess whether an ultralow dose of parental estradiol, aimed for treatment of vaginal atrophy, affects bone metabolism and bone density.STUDY DESIGN: Thirty healthy women > or = 60 years old were randomly assigned to a 6-month treatment with either an ultralow dose of parenteral estradiol (7.5 microg/24 hours) delivered by vaginal rings or no treatment in the proportion 2:1.RESULTS: Forearm bone density increased in estradiol users by 2.1% (95% confidence interval 0.4 to 3.8, p = 0.008), contrasting to a decrease in nonusers of -2.7% (95% confidence interval -5.9 to 0.4, p = 0.077). In analysis of variance the changes in the two study groups differed significantly (p = 0.0004). Consistently, serum alkaline phosphatases, bone-specific alkaline phosphatases, and osteocalcin concentrations decreased in the treatment group (8%, p = 0.019; 14%, p = 0.0006; and 9%, p = 0.02, respectively), suggesting reduced bone turnover. No significant changes were found in nonusers.CONCLUSION: Ultralow doses of estradiol may potentially prevent bone loss in women > or = 60 years old.
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