| 1. |
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| 2. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
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| 6. |
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| 7. |
- Schael, S., et al.
(författare)
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Electroweak measurements in electron positron collisions at W-boson-pair energies at LEP
- 2013
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 532:4, s. 119-244
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Forskningsöversikt (refereegranskat)abstract
- Electroweak measurements performed with data taken at the electron positron collider LEP at CERN from 1995 to 2000 are reported. The combined data set considered in this report corresponds to a total luminosity of about 3 fb(-1) collected by the four LEP experiments ALEPH, DELPHI, 13 and OPAL, at centre-of-mass energies ranging from 130 GeV to 209 GeV. Combining the published results of the four LEP experiments, the measurements include total and differential cross-sections in photon-pair, fermion-pair and four-fermion production, the latter resulting from both double-resonant WW and ZZ production as well as singly resonant production. Total and differential cross-sections are measured precisely, providing a stringent test of the Standard Model at centre-of-mass energies never explored before in electron positron collisions. Final-state interaction effects in four-fermion production, such as those arising from colour reconnection and Bose Einstein correlations between the two W decay systems arising in WW production, are searched for and upper limits on the strength of possible effects are obtained. The data are used to determine fundamental properties of the W boson and the electroweak theory. Among others, the mass and width of the W boson, m(w) and Gamma(w), the branching fraction of W decays to hadrons, B(W -> had), and the trilinear gauge-boson self-couplings g(1)(Z), K-gamma and lambda(gamma), are determined to be: m(w) = 80.376 +/- 0.033 GeV Gamma(w) = 2.195 +/- 0.083 GeV B(W -> had) = 67.41 +/- 0.27% g(1)(Z) = 0.984(-0.020)(+0.018) K-gamma - 0.982 +/- 0.042 lambda(gamma) = 0.022 +/- 0.019. (C) 2013 Elsevier B.V. All rights reserved.
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| 8. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 9. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 10. |
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| 11. |
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| 12. |
- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 13. |
- de Graauw, Th., et al.
(författare)
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The Herschel-Heterodyne Instrument for the Far-Infrared (HIFI)
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L6-
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Tidskriftsartikel (refereegranskat)abstract
- Aims: This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI) that was launched onboard ESA's Herschel Space Observatory in May 2009. Methods: The instrument is a set of 7 heterodyne receivers that are electronically tuneable, covering 480-1250 GHz with SIS mixers and the 1410-1910 GHz range with hot electron bolometer (HEB) mixers. The local oscillator (LO) subsystem comprises a Ka-band synthesizer followed by 14 chains of frequency multipliers and 2 chains for each frequency band. A pair of auto-correlators and a pair of acousto-optical spectrometers process the two IF signals from the dual-polarization, single-pixel front-ends to provide instantaneous frequency coverage of 2 × 4 GHz, with a set of resolutions (125 kHz to 1 MHz) that are better than 0.1 km s-1. Results: After a successful qualification and a pre-launch TB/TV test program, the flight instrument is now in-orbit and completed successfully the commissioning and performance verification phase. The in-orbit performance of the receivers matches the pre-launch sensitivities. We also report on the in-orbit performance of the receivers and some first results of HIFI's operations. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.
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| 14. |
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| 15. |
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| 16. |
- Randler, C., et al.
(författare)
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Animal welfare attitudes : Effects of gender and diet in university samples from 22 countries
- 2021
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Ingår i: Animals. - : MDPI AG. - 2076-2615. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Animal Welfare Attitudes (AWA) are defined as human attitudes towards the welfare of animals in different dimensions and settings. Demographic factors, such as age and gender are associated with AWA. The aim of this study was to assess gender differences among university students in a large convenience sample from twenty-two nations in AWA. A total of 7914 people participated in the study (5155 women, 2711 men, 48 diverse). Participants completed a questionnaire that collected demographic data, typical diet and responses to the Composite Respect for Animals Scale Short version (CRAS-S). In addition, we used a measure of gender empowerment from the Human Development Report. The largest variance in AWA was explained by diet, followed by country and gender. In terms of diet, 6385 participants reported to be omnivores, 296 as pescatarian, 637 ate a vegetarian diet and 434 were vegans (n = 162 without answer). Diet was related with CRAS-S scores; people with a vegan diet scored higher in AWA than omnivores. Women scored significantly higher on AWA than men. Furthermore, gender differences in AWA increased as gender inequality decreased. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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| 17. |
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Andersson, Mike, et al.
(författare)
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Development of a ChemFET sensor with molecular films of porphyrins as sensitive layer
- 2001
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Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 77:1-2, s. 567-571
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Tidskriftsartikel (refereegranskat)abstract
- The interaction of chemical species with molecular films of porphyrins causes variations of the work function of the film itself, as it has been recently demonstrated by using the Kelvin probe technique. This characteristic makes porphyrins films suitable to be used as sensitive layers in ChemFET sensors. In this paper, we present a preliminary report about the fabrication and testing of such gas sensitive devices. The technological solutions towards an optimised device are also illustrated and discussed. © 2001 Elsevier Science B.V.
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| 23. |
- Benetti, M., et al.
(författare)
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POLYSILICON MESOSCOPIC WIRES COATED BY Pd AS H(2) SENSORS
- 2009
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Ingår i: PROCEEDINGS OF THE 13TH ITALIAN CONFERENCE ON SENSORS AND MICROSYSTEMS. - SINGAPORE : WORLD SCIENTIFIC PUBL CO PTE LTD. ; , s. 161-165
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Konferensbidrag (refereegranskat)abstract
- In this work a novel monocrystalline silicon nanowires array has been investigated and presented as hydrogen sensor, designed and fabricated by employing high resolution microfabrication techniques and featuring a high surface/volume ratio. The nanowires arrays makes up the channel of a MOS system, palladium-silicon dioxide-silicon. Several devices have been fabricated by using a SOI (Silicon On Insulator) substrate, Source and Drain have been geometrically patterned by optical lithography and Boron p-doped. Electron Beam Litography (EBL) defined the MOS channel made up of a nanowires array of different length and width in different transistors. The pads of Source and Drain have been manufactured with an aluminium film deposition. The Gate has been fabricated with a grown silicon oxide layer (17.4 nm) and Palladium has been used as gate contact. Polarizing and exposing the device to H(2)/N(2) cycles at different concentrations some preliminary measurements have been successfully conducted.
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| 24. |
- Di, Natale C., et al.
(författare)
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An experimental biomimetic platform for artificial olfaction
- 2008
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 3:9
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Tidskriftsartikel (refereegranskat)abstract
- Artificial olfactory systems have been studied for the last two decades mainly from the point of view of the features of olfactory neuron receptor fields. Other fundamental olfaction properties have only been episodically considered in artificial systems. As a result, current artificial olfactory systems are mostly intended as instruments and are of poor benefit for biologists who may need tools to model and test olfactory models. Herewith, we show how a simple experimental approach can be used to account for several phenomena observed in olfaction. An artificial epithelium is formed as a disordered distributed layer of broadly selective color indicators dispersed in a transparent polymer layer. The whole epithelium is probed with colored light, imaged with a digital camera and the olfactory response upon exposure to an odor is the change of the multispectral image. The pixels are treated as olfactory receptor neurons, whose optical properties are used to build a convergence classifier into a number of mathematically defined artificial glomeruli. A non-homogenous exposure of the test structure to the odours gives rise to a time and spatial dependence of the response of the different glomeruli strikingly similar to patterns observed in the olfactory bulb. The model seems to mimick both the formation of glomeruli, the zonal nature of olfactory epithelium, and the spatio-temporal signal patterns at the glomeruli level. This platform is able to provide a readily available test vehicle for chemists developing optical indicators for chemical sensing purposes and for biologists to test models of olfactory system organization. © 2008 Di Natale et al.
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| 25. |
- Di Natale, C, et al.
(författare)
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An artificial olfaction system based on the optical imaging of a large array of chemical reporters
- 2009
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Ingår i: SENSORS AND ACTUATORS B-CHEMICAL. - : Elsevier BV. - 0925-4005. ; 142:2, s. 412-417
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Tidskriftsartikel (refereegranskat)abstract
- Electronic noses are object of research since more than two decades; nonetheless. the analogies between natural and olfaction systems are still limited to the selectivity properties of the receptors. The implementation of more sophisticated features such as the large number of receptors and the glomeruli layer have been hampered by technical difficulties related to the management of a large number of contemporaneous signals. As demonstrated in the past, optical imaging is a read-out technique for sensors development that can provide large sensor arrays. In this paper an artificial olfaction system based on the imaging of a continuous layer of chemical indicators is illustrated. The system incorporates an array of thousands of sensors, corresponding to the pixels of the image. The choice of Computer Screen Photoassisted Technology as a platform for optical interrogation of the sensing layer allows for the definition of a strategy for an automatic definition of a glomeruli layer based on the classification of the optical fingerprints of the image pixels. Chemical indicators were dissolved into a polymeric matrix providing the further property of odor diffusion mimicking the functions of the olfactory mucosa. The system has been tested in a simple experiment and data have been treated applying a lateral inhibition to the glomeruli layer resulting in a dynamic pattern resembling that observed in natural olfaction.
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| 26. |
- Di Natale, Corrado, et al.
(författare)
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Investigation of the selectivity properties of metalloporphyrines self-assembled-monolayers on QMB and FET transducers
- 2006
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Ingår i: Proc Eurosensors XX.
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Konferensbidrag (refereegranskat)abstract
- Progresses of synthetic chemistry methodologies have allowed the preparation of a great variety of artificial receptors that are particularly appealing for chemical sensor development. In this paper, we investigate and compare the properties of gas sensors based on two types of devices, quartz microbalances (QMBs) and field effect transistors (FETs), which give the means to exploit the molecular recognition events occurring in non-conductive sensing layers formed by a thiol-modified cobalt tetraphenylporphyrin (CoTPPSH). Since QMB is sensitive to mass and FET is sensitive to electric dipoles, the resulting sensors are expected to exhibit different sensitivities and selectivities, although both based on the same sensing layer. In particular we show that the high sensitivity of CoTPPSH-coated FETs towards CO and NO is a consequence of the significant CoTPPSH electric dipole change after the gas coordination to the metal centre.
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| 27. |
- Gatto, E., et al.
(författare)
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Polychromatic fingerprinting of excitation emission matrices
- 2008
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Ingår i: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 14:20, s. 6057-6060
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Tidskriftsartikel (refereegranskat)abstract
- The ability of a ubiquitous polychromatic excitation to support the fingerprinting of the Excitation Emission Matrices (EEM) of fluorescent indicators was reported. Solutions of fluorescent molecules, with concentration of 2µM for the absorption and 10µM for the emission measurements were prepared. Spectroscopic grade THF and distilled water passed through Milli-Q purification system were used as solvents. EEM measurements were carried out on a spectrofluorimeter, operating in the 390-700 nm detection range, with excitations at 20 nm intervals within the same range. During the measurement, the screen displayed a sequence of 50 colors and for every color, the transmission and emission spectrum of both the reference and the sample were recorded. Illuminating colors in the red region are not able to excite fluorescence and this can be seen in the spectra for red light.
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| 28. |
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| 29. |
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| 30. |
- Marchesini, Renato, et al.
(författare)
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In vivo spectrophotometric evaluation of neoplastic and non-neoplastic skin pigmented lesions--I. Reflectance measurements
- 1991
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Ingår i: Photochemistry and Photobiology. - : Wiley. - 0031-8655 .- 1751-1097. ; 53:1, s. 77-84
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Tidskriftsartikel (refereegranskat)abstract
- Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectance spectra of the different lesions manifest dissimilar patterns, particularly in the near IR region. Comparison of reflectance of nevi with that of malignant melanomas results in a highly significant difference (P less than 10(-6)) between the two samples. Though interpretation of the spectra remains difficult as a result of the complexity of the optical processes of scattering and absorption, our results suggest that a detailed analysis of the reflectance spectrum may give clinically useful information, and could be utilized as an aid in clinical diagnosis of cutaneous pigmented lesions, especially where malignant melanoma is concerned.
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| 31. |
- Martinelle, E, et al.
(författare)
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FET Transduction of Electric Dipole Changes in Organic Layers
- 2007
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Ingår i: TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference. - : IEEE. - 1424408423 - 1424408415 ; , s. 1895-1898
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Konferensbidrag (refereegranskat)abstract
- Modern chemistry makes possibile the production of artificial receptors endowed with interaction sites specific towards selected analytes. To fabricate chemical sensors a transducer able to preserve the selectivity of such sensing layers is requested. We demonstrate the Field Effect Transistors (FET) coated by metalloporphyrins emphasizes the coordination of analytes with the sensing molecules with respect to the weakest forces that tend to cancel the selectivity. Molecular simulations show that coordination of gases such as carbon monoxide and nitric oxide greatly change the porphyrin electric dipole both in magnitude and direction inducing a large FET signal shift.
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| 32. |
- Martinelli, E, et al.
(författare)
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Odor Processing with an experimental model of Olfactory epithelium and bulb
- 2011
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Ingår i: Chemical Senses. - : Oxford University Press. - 0379-864X .- 1464-3553. ; 36:1, s. E4-E4
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Artificial olfaction was introduced as a model tool to investigateolfaction properties [1]. Nonetheless, the only analogy between the natural and the artificial system lies just in the selectivity proper- ties of the receptors. The implementation of more sophisticated fea- tures such as the large number of receptors and the glomerular layer have been hampered by technical difficulties related to the manage- ment of large numbers of simultaneous signals.As demonstrated in the past, optical imaging is a read-out tech- nique for sensors development that can provide large sensor arrays [2]. On that basis, we recently introduced an artificial olfaction sys- tem based on the imaging of a continuous layer of chemical indi- cators [3]. In this situation an image sensor provides a segmentation of the whole sensing layer in a number of elementary units corre- sponding to the pixels of the image. Eventually, since it is possible to evaluate the optical properties of every single pixel, each pixel of the image may correspond to an individual sensor. In this regard, even low-resolution images may easily result in thousands of independ- ent sensing units.In our system a collection of arbitrarily shaped regions of color indicators is illuminated by a controlled light source; the optical characteristics of each pixel of the image are measured by a camera yielding the light intensities in the three channels red, green, and blue. The combination of illumination sequence and cameraread-out results in a fingerprint encoding the optical properties of the sensing layer portioned in image pixels. Even a simple clas- sification of these fingerprints assigns each pixel to a class, and each class contains pixels carrying the same color indicator. This behav- ior resembles the association between ORNs carrying the same chemical receptors into the same glomerulus [4]. On the basis of this analogy it is straightforward to describe the layer of indicators as an artificial epithelium, pixels of the image as artificial olfactory neu- rons, and the classes provided by the classifier as an abstract rep- resentation of artificial glomeruli.This system thus allows the generation of a complex model of olfaction, including glomerular compartmentalization [5], which is then applied to data generated by the exposure to pure and mixed gases. Results show that such a model enhances the discrimination of pure and mixed odors. Eventually, such a platform, apart from evidencing the similarities between natural and artificial olfactory systems, is also proposed as a practical tool to test olfactory models.1. K. Persaud and G. Dodds, Nature 299 (1982) 3522. Dickinson et al., Nature 382 (1996) 6973. C. Di Natale et al., PLoS ONE 3 (2008) 31394. P. Mombaerts, Annu Rev Neurosci 22 (1999) 4875. D. Schild and H. Riedel, Biophysical Journal, 61 (1992) 704
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| 33. |
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| 34. |
- Polese, D, et al.
(författare)
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Sharing data processing among replicated optical sensor arrays
- 2013
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 179:SI, s. 252-258
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Tidskriftsartikel (refereegranskat)abstract
- Sensor networks prompt a great deal of research interest within the computer and analytical sciences. To this regard, one of the most important issues is concerned with the interpretation of data that are collected by different sensors. Due to sensors non-reproducibility, this problem may also persist even when many replicas of the same sensors are considered. In this case additional calibrations may be required to use a common knowledge database. Noteworthy, the same problem arises in case of sensors replacement. In this paper we demonstrate that in case of optical chemical sensors drawing inspiration from the connectivity strategy of the olfactory bulb, this problem can find a straightforward solution when an image sensor is used to measure the optical properties of an extended sensing layer. If the sensing layer is formed by a number of spots of different indicators, it is demonstrated that a common data processing can be applied to any replica of the sensing layer even if the indicators are spotted with different geometries and in different quantities.
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| 35. |
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| 36. |
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