| 1. |
- Adrian-Martinez, S., et al.
(author)
-
A first search for coincident gravitational waves and high energy neutrinos using LIGO, Virgo and ANTARES data from 2007
- 2013
-
In: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :6
-
Journal article (peer-reviewed)abstract
- We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.
|
|
| 2. |
- Fenstermacher, M.E., et al.
(author)
-
DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
-
Journal article (peer-reviewed)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
|
|
| 3. |
- Ageron, M., et al.
(author)
-
ANTARES : The first undersea neutrino telescope
- 2011
-
In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 656:1, s. 11-38
-
Journal article (peer-reviewed)abstract
- The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given. (C) 2011 Elsevier B.V. All rights reserved.
|
|
| 4. |
- Heine, M., et al.
(author)
-
Determination of the neutron-capture rate of C-17 for r-process nucleosynthesis
- 2017
-
In: Physical Review C. - 2469-9985 .- 2469-9993. ; 95:1, s. Article no 014613 -
-
Journal article (peer-reviewed)abstract
- With the (RB)-B-3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C-18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C-17 into the ground state of C-18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C-18. This allowed to derive the astrophysical cross section sigma(n gamma)*. accounting for the thermal population of C-17 target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures T-9
|
|
| 5. |
- Leisawitz, David, et al.
(author)
-
The origins space telescope
- 2019
-
In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 11115
-
Conference paper (peer-reviewed)abstract
- The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid-and far-infrared wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of Herschel, the largest telescope flown in space to date. After a 3 1/2 year study, the Origins Science and Technology Definition Team will recommend to the Decadal Survey a concept for Origins with a 5.9-m diameter telescope cryocooled to 4.5 K and equipped with three scientific instruments. A mid-infrared instrument (MISC-T) will measure the spectra of transiting exoplanets in the 2.8-20 μm wavelength range and offer unprecedented sensitivity, enabling definitive biosignature detections. The Far-IR Imager Polarimeter (FIP) will be able to survey thousands of square degrees with broadband imaging at 50 and 250 μm. The Origins Survey Spectrometer (OSS) will cover wavelengths from 25-588 μm, make wide-area and deep spectroscopic surveys with spectral resolving power R ∼ 300, and pointed observations at R ∼ 40,000 and 300,000 with selectable instrument modes. Origins was designed to minimize complexity. The telescope has a Spitzer-like architecture and requires very few deployments after launch. The cryo-thermal system design leverages JWST technology and experience. A combination of current-state-of-the-art cryocoolers and next-generation detector technology will enable Origins' natural backgroundlimited sensitivity.
|
|
| 6. |
- Leisawitz, David, et al.
(author)
-
The Origins Space Telescope: Mission concept overview
- 2018
-
In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10698
-
Conference paper (peer-reviewed)abstract
- Downloading of the abstract is permitted for personal use only. The Origins Space Telescope (OST) will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did the universe evolve in response to its changing ingredients? How common are life-bearing planets? To accomplish its scientific objectives, OST will operate at mid- and far-infrared wavelengths and offer superlative sensitivity and new spectroscopic capabilities. The OST study team will present a scientifically compelling, executable mission concept to the 2020 Decadal Survey in Astrophysics. To understand the concept solution space, our team studied two alternative mission concepts. We report on the study approach and describe both of these concepts, give the rationale for major design decisions, and briefly describe the mission-enabling technology.
|
|
| 7. |
- Bender, R., et al.
(author)
-
Corrosion challenges towards a sustainable society
- 2022
-
In: Materials and corrosion - Werkstoffe und Korrosion. - : Wiley. - 0947-5117 .- 1521-4176. ; 73:11, s. 1730-1751
-
Journal article (peer-reviewed)abstract
- A global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate-resilient energy systems and infrastructures brings with it a long-term direction, so as a result the long-term behaviour of structural materials (mainly metals and alloys) becomes a major prospect. With this in mind “Corrosion Challenges Towards a Sustainable Society” presents a series of cases showing the importance of corrosion protection of metals and alloys in the development of energy production to further understand the science of corrosion, and bring the need for research and the consequences of corrosion into public and political focus. This includes emphasis on the limitation of greenhouse gas emissions, on the lifetime of infrastructures, implants, cultural heritage artefacts, and a variety of other topics.
|
|
| 8. |
- Leisawitz, David, et al.
(author)
-
Origins Space Telescope: Baseline mission concept
- 2021
-
In: Journal of Astronomical Telescopes, Instruments, and Systems. - 2329-4221 .- 2329-4124. ; 7:1
-
Journal article (peer-reviewed)abstract
- The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the Universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid-and far-infrared (IR) wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of the Herschel Space Observatory, the largest telescope flown in space to date. We describe the baseline concept for Origins recommended to the 2020 US Decadal Survey in Astronomy and Astrophysics. The baseline design includes a 5.9-m diameter telescope cryocooled to 4.5 K and equipped with three scientific instruments. A mid-infrared instrument (Mid-Infrared Spectrometer and Camera Transit spectrometer) will measure the spectra of transiting exoplanets in the 2.8 to 20 μm wavelength range and offer unprecedented spectrophotometric precision, enabling definitive exoplanet biosignature detections. The far-IR imager polarimeter will be able to survey thousands of square degrees with broadband imaging at 50 and 250 μm. The Origins Survey Spectrometer will cover wavelengths from 25 to 588 μm, making wide-area and deep spectroscopic surveys with spectral resolving power R ∼ 300, and pointed observations at R ∼ 40,000 and 300,000 with selectable instrument modes. Origins was designed to minimize complexity. The architecture is similar to that of the Spitzer Space Telescope and requires very few deployments after launch, while the cryothermal system design leverages James Webb Space Telescope technology and experience. A combination of current-state-of-the-art cryocoolers and next-generation detector technology will enable Origins' natural background-limited sensitivity.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Soranno, Patricia A., et al.
(author)
-
LAGOS-NE : A multi-scaled geospatial and temporal database of lake ecological context and water quality for thousands of U.S. lakes
- 2017
-
In: GigaScience. - : Oxford University Press (OUP). - 2047-217X. ; 6:12, s. 1-22
-
Journal article (peer-reviewed)abstract
- Understanding the factors that affect water quality and the ecological services provided by freshwater ecosystems is an urgent global environmental issue. Predicting how water quality will respond to global changes not only requires water quality data, but also information about the ecological context of individual water bodies across broad spatial extents. Because lake water quality is usually sampled in limited geographic regions, often for limited time periods, assessing the environmental controls of water quality requires compilation of many data sets across broad regions and across time into an integrated database. LAGOS-NE accomplishes this goal for lakes in the northeastern-most 17 US states. LAGOS-NE contains data for 51101 lakes and reservoirs larger than 4 ha in 17 lake-rich US states. The database includes 3 datamodules for: lake location and physical characteristics for all lakes; ecological context (i.e., the land use, geologic, climatic, and hydrologic setting of lakes) for all lakes; and in situmeasurements of lake water quality for a subset of the lakes fromthe past 3 decades for approximately 2600–12 000 lakes depending on the variable. The database contains approximately 150000 measures of total phosphorus, 200 000 measures of chlorophyll, and 900 000 measures of Secchi depth. The water quality data were compiled from87 lake water quality data sets fromfederal, state, tribal, and non-profit agencies, university researchers, and citizen scientists. This database is one of the largest andmost comprehensive databases of its type because it includes both in situmeasurements and ecological context data. Because ecological context can be used to study a variety of other questions about lakes, streams, and wetlands, this database can also be used as the foundation for other studies of freshwaters at broad spatial and ecological scales
|
|
| 12. |
- Arguedas Cuendis, S., et al.
(author)
-
First results on the search for chameleons with the KWISP detector at CAST
- 2019
-
In: Physics of the Dark Universe. - : Elsevier. - 2212-6864. ; 26
-
Journal article (peer-reviewed)abstract
- We report on a first measurement with a sensitive opto-mechanical force sensor designed for the direct detection of coupling of real chameleons to matter. These dark energy candidates could be produced in the Sun and stream unimpeded to Earth. The KWISP detector installed on the CAST axion search experiment at CERN looks for tiny displacements of a thin membrane caused by the mechanical effect of solar chameleons. The displacements are detected by a Michelson interferometer with a homodyne readout scheme. The sensor benefits from the focusing action of the ABRIXAS X-ray telescope installed at CAST, which increases the chameleon flux on the membrane. A mechanical chopper placed between the telescope output and the detector modulates the incoming chameleon stream. We present the results of the solar chameleon measurements taken at CAST in July 2017, setting an upper bound on the force acting on the membrane of 80pN at 95% confidence level. The detector is sensitive for direct coupling to matter 104≤βm≤108, where the coupling to photons is locally bound to βγ≤1011.
|
|
| 13. |
- Battersby, C., et al.
(author)
-
The Origins Space Telescope
- 2018
-
In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 2:8, s. 596-599
-
Journal article (other academic/artistic)abstract
- The Origins Space Telescope, one of four large Mission Concept Studies sponsored by NASA for review in the 2020 US Astrophysics Decadal Survey, will open unprecedented discovery space in the infrared, unveiling our cosmic origins.
|
|
| 14. |
- Goldstone, A. P., et al.
(author)
-
Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity
- 2016
-
In: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 101:2, s. 599-609
-
Journal article (peer-reviewed)abstract
- Context: Roux-en-Y gastric bypass (RYGB) surgery is an effective long-term intervention for weight loss maintenance, reducing appetite, and also food reward, via unclear mechanisms. Objective: To investigate the role of elevated satiety gut hormones after RYGB, we examined food hedonic-reward responses after their acute post-prandial suppression. Design: These were randomized, placebo-controlled, double-blind, crossover experimental medicine studies. Patients: Two groups, more than 5 months after RYGB for obesity (n = 7-11), compared with nonobese controls (n = 10), or patients after gastric banding (BAND) surgery (n = 9) participated in the studies. Intervention: Studies were performed after acute administration of the somatostatin analog octreotide or saline. In one study, patients after RYGB, and nonobese controls, performed a behavioral progressive ratio task for chocolate sweets. In another study, patients after RYGB, and controls after BAND surgery, performed a functional magnetic resonance imaging food picture evaluation task. Main Outcome Measures: Octreotide increased both appetitive food reward (breakpoint) in the progressive ratio task (n = 9), and food appeal (n = 9) and reward system blood oxygen level dependent signal (n = 7) in the functional magnetic resonance imaging task, in the RYGB group, but not in the control groups. Results: Octreotide suppressed postprandial plasma peptide YY, glucagon-like peptide-1, and fibroblast growth factor-19 after RYGB. The reduction in plasma peptide YY with octreotide positively correlated with the increase in brain reward system blood oxygen level-dependent signal in RYGB/BAND subjects, with a similar trend for glucagon-like peptide-1. Conclusions: Enhanced satiety gut hormone responses after RYGB may be a causative mechanism by which anatomical alterations of the gut in obesity surgery modify behavioral and brain reward responses to food.
|
|
| 15. |
- Meixner, Margaret, et al.
(author)
-
Origins Space Telescope science drivers to design traceability
- 2021
-
In: Journal of Astronomical Telescopes, Instruments, and Systems. - 2329-4221 .- 2329-4124. ; 7:1
-
Journal article (peer-reviewed)abstract
- The Origins Space Telescope (Origins) concept is designed to investigate the creation and dispersal of elements essential to life, the formation of planetary systems, and the transport of water to habitable worlds and the atmospheres of exoplanets around nearby K-and M-dwarfs to identify potentially habitable-and even inhabited-worlds. These science priorities are aligned with NASA's three major astrophysics science goals: How does the Universe work? How did we get here? and Are we alone? We briefly describe the science case that arose from the astronomical community and the science traceability matrix for Origins. The science traceability matrix prescribes the design of Origins and demonstrates that it will address the key science questions motivated by the science case.
|
|
| 16. |
- Niemann, C., Rosmej, F.B., Tauschwitz, A., Neff, S., Penache, D., Birkner, R., Constantin, C., Knobloch, R., Presura, R., Hoffmann, D.H.H., Yu, S.S., Lee, R.W.
(author)
-
pectroscopic density and temperature measurements and modelling of a discharge plasma for neutralized ion-beam transport.
- 2003
-
In: J.Physics D-Appl. Physics. ; 36, s. 2102-9
-
Journal article (peer-reviewed)
|
|
| 17. |
- Stoehlker, Th., et al.
(author)
-
APPA at FAIR : From fundamental to applied research
- 2015
-
In: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 235, s. 680-685
-
Journal article (peer-reviewed)abstract
- FAIR with its intense beams of ions and antiprotons provides outstanding and worldwide unique experimental conditions for extreme matter research in atomic and plasma physics and for application oriented research in biophysics, medical physics and materials science. The associated research programs comprise interaction of matter with highest electromagnetic fields, properties of plasmas and of solid matter under extreme pressure, density, and temperature conditions, simulation of galactic cosmic radiation, research in nanoscience and charged particle radiotherapy. A broad variety of APPA-dedicated facilities including experimental stations, storage rings, and traps, equipped with most sophisticated instrumentation will allow the APPA community to tackle new challenges. The worldwide most intense source of slow antiprotons will expand the scope of APPA related research to the exciting field of antimatter.
|
|
| 18. |
- Sun, Jielun, et al.
(author)
-
Review of wave-turbulence interactions in the stable atmospheric boundary layer
- 2015
-
In: Reviews of geophysics. - 8755-1209 .- 1944-9208. ; 53:3, s. 956-993
-
Research review (peer-reviewed)abstract
- Flow in a stably stratified environment is characterized by anisotropic and intermittent turbulence and wavelike motions of varying amplitudes and periods. Understanding turbulence intermittency and wave-turbulence interactions in a stably stratified flow remains a challenging issue in geosciences including planetary atmospheres and oceans. The stable atmospheric boundary layer (SABL) commonly occurs when the ground surface is cooled by longwave radiation emission such as at night over land surfaces, or even daytime over snow and ice surfaces, and when warm air is advected over cold surfaces. Intermittent turbulence intensification in the SABL impacts human activities and weather variability, yet it cannot be generated in state-of-the-art numerical forecast models. This failure is mainly due to a lack of understanding of the physical mechanisms for seemingly random turbulence generation in a stably stratified flow, in which wave-turbulence interaction is a potential mechanism for turbulence intermittency. A workshop on wave-turbulence interactions in the SABL addressed the current understanding and challenges of wave-turbulence interactions and the role of wavelike motions in contributing to anisotropic and intermittent turbulence from the perspectives of theory, observations, and numerical parameterization. There have been a number of reviews on waves, and a few on turbulence in stably stratified flows, but not much on wave-turbulence interactions. This review focuses on the nocturnal SABL; however, the discussions here on intermittent turbulence and wave-turbulence interactions in stably stratified flows underscore important issues in stably stratified geophysical dynamics in general.
|
|
| 19. |
|
|
| 20. |
- Balzani, D., et al.
(author)
-
A polyconvex framework for soft biological tissues. Adjustment to experimental data
- 2006
-
In: International Journal of Solids and Structures. - : Elsevier BV. - 0020-7683 .- 1879-2146. ; 43:20, s. 6052-6070
-
Journal article (peer-reviewed)abstract
- The main goal of this contribution is to provide a simple method for constructing transversely isotropic polyconvex functions suitable for the description of biological soft tissues. The advantage of our approach is that only a few parameters are necessary to approximate a variety of stress-strain curves and to satisfy the condition of a stress-free reference configuration a priori in the framework of polyconvexity. The proposed polyconvex stored energies are embedded into the concept of structural tensors and the representation theorems for isotropic tensor functions are utilized. As an example, the medial layer of a human abdominal aorta is investigated, modeled by some of the proposed polyconvex functions and compared with experimental data. Hereby, the economic fitting to experimental data, and hence the easy handling of the functions is shown.
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
- Meixner, Margaret, et al.
(author)
-
Overview of the Origins Space telescope: Science drivers to observatory requirements
- 2018
-
In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10698
-
Conference paper (peer-reviewed)abstract
- The Origins Space Telescope (OST) mission concept study is the subject of one of the four science and technology definition studies supported by NASA Headquarters to prepare for the 2020 Astronomy and Astrophysics Decadal Survey. OST will survey the most distant galaxies to discern the rise of metals and dust and to unveil the co-evolution of galaxy and blackhole formation, study the Milky Way to follow the path of water from the interstellar medium to habitable worlds in planetary systems, and measure biosignatures from exoplanets. This paper describes the science drivers and how they drove key requirements for OST Mission Concept 2, which will operate between ∼5 and ∼600 microns with a JWST sized telescope. Mission Concept 2 for the OST study optimizes the engineering for the key science cases into a powerful and more economical observatory compared to Mission Concept 1.
|
|
| 24. |
- Neff, A, et al.
(author)
-
The ESTMJS (European Society of Temporomandibular Joint Surgeons) Consensus and Evidence-Based Recommendations on Management of Condylar Dislocation
- 2021
-
In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 10:21
-
Journal article (peer-reviewed)abstract
- Although condylar dislocation is not uncommon, terminology, diagnostics, and treatment concepts vary considerably worldwide. This study aims to present a consensus recommendation based on systematically reviewed literature and approved by the European Society of TMJ Surgeons (ESTMJS). Based on the template of the evidence-based German guideline (register # 007-063) the ESTMJS members voted on 30 draft recommendations regarding terminology, diagnostics, and treatment initially via a blinded modified Delphi procedure. After unblinding, a discussion and voting followed, using a structured consensus process in 2019. An independent moderator documented and evaluated voting results and alterations from the original draft. Although the results of the preliminary voting were very heterogenous and differed significantly from the German S3 guideline (p < 0.0005), a strong consensus was achieved in the final voting on terminology, diagnostics, and treatment. In this voting, multiple alterations, including adding and discarding recommendations, led to 24 final recommendations on assessment and management of TMJ dislocation. To our knowledge, the ESTMJS condylar dislocation recommendations are the first both evidence and consensus-based international recommendations in the field of TMJ surgery. We recommend they form the basis for clinical practice guidelines for the management of dislocations of the mandibular condyle.
|
|
| 25. |
- Neff, Bryan D., et al.
(author)
-
Polyandry and alternative mating tactics
- 2013
-
In: Philosophical Transactions of the Royal Society B: Biological Sciences. - : The Royal Society. - 1471-2970 .- 0962-8436. ; 368:1613
-
Research review (peer-reviewed)abstract
- Many species in the animal kingdom are characterized by alternative mating tactics (AMTs) within a sex. In males, such tactics include mate guarding versus sneaking behaviours, or territorial versus female mimicry. Although AMTs can occur in either sex, they have been most commonly described in males. This sex bias may, in part, reflect the increased opportunity for sexual selection that typically exists in males, which can result in a higher probability that AMTs evolve in that sex. Consequently, females and polyandry can play a pivotal role in governing the reproductive success associated with male AMTs and in the evolutionary dynamics of the tactics. In this review, we discuss polyandry and the evolution of AMTs. First, we define AMTs and review game theoretical and quantitative genetic approaches used to model their evolution. Second, we review several examples of AMTs, highlighting the roles that genes and environment play in phenotype expression and development of the tactics, as well as empirical approaches to differentiating among the mechanisms. Third, ecological and genetic constraints to the evolution of AMTs are discussed. Fourth, we speculate on why female AMTs are less reported on in the literature than male tactics. Fifth, we examine the effects of AMTs on breeding outcomes and female fitness, and as a source, and possibly also a consequence, of sexual conflict. We conclude by suggesting a new model for the evolution of AMTs that incorporates both environmental and genetic effects, and discuss some future avenues of research.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- Neff, J. and Caldwell, K.D.
(author)
-
Surface Modification of Biomaterials.
- 1999
-
In: A. von Recum, (ed.), Handbook of Biomaterials. - : Taylor & Francis, Philadelphia. ; , s. 201-226
-
Book chapter (other academic/artistic)
|
|
| 29. |
- Zulkifli, M, et al.
(author)
-
Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
- 2020
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4866-
-
Journal article (peer-reviewed)abstract
- Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein complex whose assembly in the inner mitochondrial membrane is facilitated by the scaffold factor MCUR1. Intriguingly, many fungi that lack MCU contain MCUR1 homologs, suggesting alternate functions. Herein, we characterize Saccharomyces cerevisiae homologs Put6 and Put7 of MCUR1 as regulators of mitochondrial proline metabolism. Put6 and Put7 are tethered to the inner mitochondrial membrane in a large hetero-oligomeric complex, whose abundance is regulated by proline. Loss of this complex perturbs mitochondrial proline homeostasis and cellular redox balance. Yeast cells lacking either Put6 or Put7 exhibit a pronounced defect in proline utilization, which can be corrected by the heterologous expression of human MCUR1. Our work uncovers an unexpected role of MCUR1 homologs in mitochondrial proline metabolism.
|
|
