| 1. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 2. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Ngo, Son Tung, et al.
(författare)
-
Distal Hydrophobic Loop Modulates the Copper Active Site and Reaction of AA13 Polysaccharide Monooxygenases
- 2022
-
Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 126:39, s. 7567-7578
-
Tidskriftsartikel (refereegranskat)abstract
- Polysaccharide monooxygenases (PMOs) use a type-2 copper center to activate O2 for the selective hydroxylation of one of the two C-H bonds of glycosidic linkages. Our electron paramagnetic resonance (EPR) analysis and molecular dynamics (MD) simulations suggest the unprecedented dynamic roles of the loop containing the residue G89 (G89 loop) on the active site structure and reaction cycle of starch-active PMOs (AA13 PMOs). In the Cu(II) state, the G89 loop could switch between an open and closed conformation, which is associated with the binding and dissociation of an aqueous ligand in the distal site, respectively. The conformation of the G89 loop influences the positioning of the copper center on the preferred substrate of AA13 PMOs. The dissociation of the distal ligand results in the bending of the T-shaped core of the Cu(II) active site, which could help facilitate its reduction to the active Cu(I) state. In the Cu(I) state, the G89 loop is in the closed conformation with a confined copper center, which could allow for efficient O2 binding. In addition, the G89 loop remains in the closed conformation in the Cu(II)-superoxo intermediate, which could prevent off-pathway superoxide release via exchange with the distal aqueous ligand. Finally, at the end of the reaction cycle, aqueous ligand binding to the distal site could switch the G89 loop to the open conformation and facilitate product release.
|
|
| 4. |
|
|
| 5. |
- Nguyen, T. H., et al.
(författare)
-
Pilot Assignment for Joint Uplink-Downlink Spectral Efficiency Enhancement in Massive MIMO Systems with Spatial Correlation
- 2021
-
Ingår i: IEEE Transactions on Vehicular Technology. - : Institute of Electrical and Electronics Engineers Inc.. - 0018-9545 .- 1939-9359. ; 70:8, s. 8292-8297
-
Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a flexible pilot assignment method to jointly optimize the uplink and downlink data transmission in multi-cell Massive multiple input multiple output (MIMO) systems with correlated Rayleigh fading channels. By utilizing a closed-form expression of the ergodic spectral efficiency (SE) achieved with maximum ratio processing, we formulate an optimization problem for maximizing the minimum weighted sum of the uplink and downlink SEs subject to the transmit powers and pilot assignment sets. This combinatiorial optimization problem is solved by two sequential algorithms: a heuristic pilot assignment is first proposed to obtain a good pilot reuse set and the data power control is then implemented. Numerical results manifest that the proposed algorithm converges fast to a better minimum sum SE per user than the algorithms in previous works.
|
|
| 6. |
- Pagan, C, et al.
(författare)
-
The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders.
- 2014
-
Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 4
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated whole-blood serotonin and decreased plasma melatonin (a circadian synchronizer hormone that derives from serotonin) have been reported independently in patients with autism spectrum disorders (ASDs). Here, we explored, in parallel, serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD and their relatives. We then investigated the clinical correlates of these biochemical parameters. Whole-blood serotonin, platelet NAS and plasma melatonin were assessed in 278 patients with ASD, their 506 first-degree relatives (129 unaffected siblings, 199 mothers and 178 fathers) and 416 sex- and age-matched controls. We confirmed the previously reported hyperserotonemia in ASD (40% (35-46%) of patients), as well as the deficit in melatonin (51% (45-57%)), taking as a threshold the 95th or 5th percentile of the control group, respectively. In addition, this study reveals an increase of NAS (47% (41-54%) of patients) in platelets, pointing to a disruption of the serotonin-NAS-melatonin pathway in ASD. Biochemical impairments were also observed in the first-degree relatives of patients. A score combining impairments of serotonin, NAS and melatonin distinguished between patients and controls with a sensitivity of 80% and a specificity of 85%. In patients the melatonin deficit was only significantly associated with insomnia. Impairments of melatonin synthesis in ASD may be linked with decreased 14-3-3 proteins. Although ASDs are highly heterogeneous, disruption of the serotonin-NAS-melatonin pathway is a very frequent trait in patients and may represent a useful biomarker for a large subgroup of individuals with ASD.
|
|
| 7. |
- Tran, Son N., et al.
(författare)
-
Improving Recurrent Neural Networks with Predictive Propagation for Sequence Labelling
- 2018
-
Ingår i: Neural Information Processing. - Cham : Springer. - 9783030041663 - 9783030041670 ; , s. 452-462
-
Konferensbidrag (refereegranskat)abstract
- Recurrent neural networks (RNNs) is a useful tool for sequence labelling tasks in natural language processing. Although in practice RNNs suffer a problem of vanishing/exploding gradient, their compactness still offers efficiency and make them less prone to overfitting. In this paper we show that by propagating the prediction of previous labels we can improve the performance of RNNs while keeping the number of parameters in RNNs unchanged and adding only one more step for inference. As a result, the models are still more compact and efficient than other models with complex memory gates. In the experiment, we evaluate the idea on optical character recognition and Chunking which achieve promising results.
|
|
| 8. |
- Tran, Son N., et al.
(författare)
-
On multi-resident activity recognition in ambient smart-homes
- 2020
-
Ingår i: Artificial Intelligence Review. - : Springer. - 0269-2821 .- 1573-7462. ; 53:6, s. 3929-3945
-
Tidskriftsartikel (refereegranskat)abstract
- Increasing attention to the research on activity monitoring in smart homes has motivated the employment of ambient intelligence to reduce the deployment cost and solve the privacy issue. Several approaches have been proposed for multi-resident activity recognition, however, there still lacks a comprehensive benchmark for future research and practical selection of models. In this paper, we study different methods for multi-resident activity recognition and evaluate them on the same sets of data. In particular, we explore the effectiveness and efficiency of temporal learning algorithms using sequential data and non-temporal learning algorithms using temporally-manipulated features. In the experiments we compare and analyse the results of the studied methods using datasets from three smart homes.
|
|
