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- Yi-Ting, Lin, 1981-, et al.
(författare)
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Association of the gut microbiome composition with 24-hour blood pressure measurements in 4,459 participants from the SCAPIS cohort
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundHypertension is a multifactorial condition affected by genetic and environmental factors. Previous studies have indicated a link between gut microbiome characteristics and blood pressure regulation but studies were limited by small sample size, restriction to office measurements, and/or using amplicon sequencing techniques, limiting taxonomic resolution and functional profiling. This study aims to examine the relationship between the gut microbiome composition measured with deep shotgun metagenomics and blood pressure measured over 24 hours.MethodsWe analyzed data from 4,459 participants without antihypertensive medication from two sites of the Swedish CArdioPulmonary BioImage Study (SCAPIS). In the first step, we assessed the association of each metagenomic species with mean 24-hour systolic and diastolic blood pressure in regression models adjusting for age, sex, country of birth, plate effect and microbiota richness, in 3,480 participants from Uppsala. Species identified in the first step were assessed for replication in the 879 participants from Malmö/Lund. As a second step, we applied models additionally adjusted for smoking, renal function, and diabetes mellitus.ResultsWe found Dorea longicatena to be positively associated with both systolic and diastolic blood pressure in fully adjusted models and Alistipes sp. 6CPBBH3, to be negatively associated. Dorea longicatena and Alistipes family have previously both been linked to metabolic outcomes. Moreover, we found Roseburia faecis and Collinsella aerofaciens to be positively associated with mean systolic blood pressure, and Fusicatenibacter saccharivorans, Coprococcus comes, and Clostridium sp. TM06-18 positively with mean diastolic blood pressure in the fully adjusted analysis. ConclusionsIn the large, well characterized population-based study SCAPIS, we found specific bacterial species associated with blood pressure. Further studies are needed to understand the causal mechanisms.
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