| 1. |
- Cederlöf, Erik, et al.
(författare)
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Antipsychotic medications and sleep problems in patients with schizophrenia
- 2024
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Ingår i: Schizophrenia Research. - : Elsevier. - 0920-9964 .- 1573-2509. ; 267, s. 230-238
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear.Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h).Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83–2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98–4.44, p < .001).Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics.
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| 2. |
- Khanna, Chand, et al.
(författare)
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The dog as a cancer model
- 2006
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 24:9, s. 1065-1066
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Lähteenvuo, Markku, et al.
(författare)
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Cohort profile: SUPER-Finland - the Finnish study for hereditary mechanisms of psychotic disorders
- 2023
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to include Asian, Latin American and African populations in addition to known population isolates, such as Finland.PARTICIPANTS: 10 474 individuals aged 18 years or older were recruited throughout the country. The subjects have been genotyped with a genome-wide genotyping chip and exome sequenced. A subset of 897 individuals selected from known population sub-isolates were selected for whole-genome sequencing. Recruitment was done between November 2015 and December 2018.FINDINGS TO DATE: 5757 (55.2%) had a diagnosis of schizophrenia, 944 (9.1%) schizoaffective disorder, 1612 (15.5%) type I or type II bipolar disorder, 532 (5.1 %) psychotic depression, 1047 (10.0%) other psychosis and for 530 (5.1%) self-reported psychosis at recruitment could not be confirmed from register data. Mean duration of schizophrenia was 22.0 years at the time of the recruitment. By the end of the year 2018, 204 of the recruited individuals had died. The most common cause of death was cardiovascular disease (n=61) followed by neoplasms (n=40). Ten subjects had psychiatric morbidity as the primary cause of death.FUTURE PLANS: Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.
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| 4. |
- Moghadasi, Ramin, et al.
(författare)
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Determining Gas Re-Mobilization and Critical Saturation : From Field Scale CO2 Injection Experiments to Pore-Scale Modelling
- 2022
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Ingår i: Proceedings of the 16th Greenhouse Gas Control Technologies Conference (GHGT-16) 23-24 Oct 2022. - : Greenhouse Gas Control Technologies (GHGT).
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Konferensbidrag (refereegranskat)abstract
- Residual trapping is a key mechanism in geological CO2 storage, which is quantitively characterized by residual gas saturation (Sgr). Remobilization of residually trapped CO2 can occur during pressure depletion, which can take place due to dissipation of near wellbore pressure build-up or any type of leakage. The occurrence of remobilization is characterized quantitively by critical gas saturation (Sgc). In this study, we present the first ever field-scale observations of trapped gas remobilization in the context of CO2 storage. We then present the preliminary results from pore-network modelling (PNM) study using a 3D network constructed from a series of X-ray computed tomography (CT) on Heletz sandstone. Our findings provide a multi-scale insight into the remobilization process in the context of CO2 storage and outline future work in terms of modelling the process to achieve a better assessment of stability of CO2 residual trapping in long-terms.
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| 5. |
- Moghadasi, Ramin, et al.
(författare)
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Determining residual gas remobilization and critical saturation in geological CO2 storage by pore-scale modelling
- 2022
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Remobilization of residually trapped CO2 as a result of pressure depletion occurs inherently at the pore-scale but affects the long-term stability of the residual trapping of CO2 at larger scales. In this study, pore-network modelling (PNM) is used to investigate this phenomenon under pressure depletion conditions. 3D networks of Bentheimer and Heletz sandstone as well as statistically generated generic 2D and 3D networks are used. The gas remobilization does occur at a higher gas saturation than residual saturation, so-called critical saturation. The difference is denoted as mobilization saturation, which varies according to the network properties (e.g., dimensionality) and the processes/mechanisms involved. Slightly smaller values are obtained for 3D networks due to the higher order of geometric connectivity between the pores and the effects of gravity. Regardless of the network types and properties, Ostwald ripening tends to slightly increase the mobilization saturation, thereby enhancing the security of residual trapping. Moreover, a significant hysteresis and reduction in gas relative permeability is observed during the depletion process, implying slow reconnection of the trapped gas clusters. These observations are safety enhancing features, due to which the remobilization of the residual trapped CO2 is delayed. The results, which are consistent with our previous analysis of field-scale Heletz experiments, have important implications for underground gas and CO2 storage. In the context of geological CO2 storage, they provide important insights into the fate of residual trapping in both the short and long term.
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| 6. |
- Moghadasi, Ramin, et al.
(författare)
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Pore-scale characterization of residual phase remobilization in geological CO2 storage using X-ray microtomography and pore-network modelling
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this study, the pore-scale characteristics of trapped CO2 remobilization under pressure depletion conditions were studied with the use of 3D X-ray microtomography and pore-network modelling. Three-dimensional X-ray microtomographic images of a sandstone sample with a voxel size of 3.83 mm were acquired from which a pore network was extracted. Experimental results show that trapped CO2 remobilization during pressure depletion is an intermittent process in nature, due to which the CO2 relative permeability is significantly reduced. This serves as a safety enhancing feature as it delays CO2 remobilization and migration. Ostwald ripening plays a significant role in the CO2 phase redistribution, which could potentially lead to remobilization even in the absence of pressure depletion. According to the pore network simulation results, weakly wetting conditions enhances the reconnection of the trapped CO2 ganglia, which in turn promotes the remobilization of the trapped phase. The simulation and experimental results agree in terms of the saturation increment needed to remobilize the CO2 – approximately 0.06 – and the pressure at which the CO2 connects – around 7 MPa. The findings of the current study provide valuable insights into the pore-scale aspects of trapped phase remobilization, a phenomenon that affects the fate of CO2 residual trapping in both the short and long term.
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| 7. |
- Moghadasi, Ramin, et al.
(författare)
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Pore‐Scale Determination of Residual Gas Remobilization and Critical Saturation in Geological CO2 Storage : A Pore‐Network Modeling Approach
- 2023
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Ingår i: Water resources research. - : American Geophysical Union (AGU). - 0043-1397 .- 1944-7973. ; 59:6
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Tidskriftsartikel (refereegranskat)abstract
- Remobilization of residually trapped CO2 can occur under pressure depletion, caused by any sort of leakage, brine extraction for pressure maintenance purposes, or simply by near wellbore pressure dissipation once CO2 injection has ceased. This phenomenon affects the long-term stability of CO2 residual trapping and should therefore be considered for an accurate assessment of CO2 storage security. In this study, pore-network modeling is performed to understand the relevant physics of remobilization. Gas remobilization occurs at a higher gas saturation than the residual saturation, the so-called critical saturation; the difference is called the mobilization saturation, a parameter that is a function of the network properties and the mechanisms involved. Regardless of the network type and properties, Ostwald ripening tends to slightly increase the mobilization saturation, thereby enhancing the security of residual trapping. Moreover, significant hysteresis and reduction in gas relative permeability is observed, implying slow reconnection of the trapped gas clusters. These observations are safety enhancing features, due to which the remobilization of residual CO2 is delayed. The results, consistent with our previous analysis of the field-scale Heletz experiments, have important implications for underground gas and CO2 storage. In the context of CO2 storage, they provide important insights into the fate of residual trapping in both the short and long term.
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