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- Brooks, BR, et al.
(författare)
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CHARMM: the biomolecular simulation program
- 2009
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Ingår i: Journal of computational chemistry. - : Wiley. - 1096-987X .- 0192-8651. ; 30:10, s. 1545-1614
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Brooks, CL III, et al.
(författare)
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Biomolecular dynamics in the 21st century
- 2024
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Ingår i: Biochimica et biophysica acta. General subjects. - 1872-8006. ; 1868:2, s. 130534-
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Tidskriftsartikel (refereegranskat)
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- Clarke, DL, et al.
(författare)
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Generalized potential of adult neural stem cells
- 2000
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 288:5471, s. 1660-1663
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Tidskriftsartikel (refereegranskat)abstract
- The differentiation potential of stem cells in tissues of the adult has been thought to be limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.
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- Healy, JA, et al.
(författare)
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Cholinergic augmentation of insulin release requires ankyrin-B
- 2010
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Ingår i: Science signaling. - : American Association for the Advancement of Science (AAAS). - 1937-9145 .- 1945-0877. ; 3:113, s. ra19-
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Tidskriftsartikel (refereegranskat)abstract
- The scaffolding protein ankyrin-B is needed for maximal insulin release, and loss of function is a risk factor for diabetes.
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- Jain, M, et al.
(författare)
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A systematic survey of lipids across mouse tissues
- 2014
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Ingår i: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 306:8, s. E854-E868
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Tidskriftsartikel (refereegranskat)abstract
- Lipids are a diverse collection of macromolecules essential for normal physiology, but the tissue distribution and function for many individual lipid species remain unclear. Here, we report a mass spectrometry survey of lipid abundance across 18 mouse tissues, detecting ∼1,000 mass spectrometry features, of which we identify 179 lipids from the glycerolipids, glycerophospholipids, lysophospholipids, acylcarnitines, sphingolipids, and cholesteryl ester classes. Our data reveal tissue-specific organization of lipids and can be used to generate testable hypotheses. For example, our data indicate that circulating triglycerides positively and negatively associated with future diabetes in humans are enriched in mouse adipose tissue and liver, respectively, raising hypotheses regarding the tissue origins of these diabetes-associated lipids. We also integrate our tissue lipid data with gene expression profiles to predict a number of substrates of lipid-metabolizing enzymes, highlighting choline phosphotransferases and sterol O-acyltransferases. Finally, we identify several tissue-specific lipids not present in plasma under normal conditions that may be of interest as biomarkers of tissue injury, and we show that two of these lipids are released into blood following ischemic brain injury in mice. This resource complements existing compendia of tissue gene expression and may be useful for integrative physiology and lipid biology.
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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 41. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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