| 1. |
- Nilsson, E.J.C., et al.
(författare)
-
Using microdispensing to manufacture a customized cell dish for microbeam irradiation of single, living cells
- 2009
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 267:7, s. 1199-1205
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper is described the preparation of patterned cell dishes to be used in studies of low dose irradiation effects on living cells. Using a droplet microdispenser, an 8 mu m thick polypropylene cell substrate, to which cells do not naturally adhere, was coated in a matrix pattern with the cell adhesive mussel protein Cell-Tak. Cells were shown to adhere and grow on the protein-coated spots, but not on the uncoated parts, providing for guided cell growth. Cultivation of isolated cell colonies provides an opportunity to study how low doses of ionizing radiation affect neighbouring un-irradiated cell colonies. (C) 2009 Elsevier B.V. All rights reserved.
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| 2. |
- Dereke, Jonatan, et al.
(författare)
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Soluble CD163 and TWEAK in early pregnancy gestational diabetes and later glucose intolerance
- 2019
-
Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:5
-
Tidskriftsartikel (refereegranskat)abstract
- Gestational diabetes mellitus (GDM) is today universally diagnosed during late pregnancy. Treating hyperglycaemia during pregnancy reduces the risk of complications, the effect of interventions is however limited due to the late diagnosis. It is thus important to identify biomarkers reaching a high precision for GDM development in early pregnancy. Here we aim to investigate soluble CD163 (sCD163) and soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) in early pregnancy GDM and their association to the development of later glucose intolerance. In this case-control study, women diagnosed with GDM in early pregnancy (n = 70) at Lund University Hospital, Lund, Sweden in 2011–2015 were age- and BMI matched to pregnant volunteers without diabetes (n = 70) recruited in early pregnancy from maternal health care centres in 2014–2015. Plasma levels of sCD163 and sTWEAK were analysed using commercial ELISA. Plasma levels of sCD163 did not differ between patients with and without GDM in early pregnancy (p = 0.86), plasma levels of sTWEAK however was decreased in women with GDM (0.71 [0.4–1.75] ng/ml) compared to controls (1.38 [0.63–4.86] ng/ml; p = 0.003). Women with sTWEAK levels in the lowest tertile had an increased risk of GDM in early pregnancy (p = 0.014). Neither sCD163 nor sTWEAK were associated with later glucose intolerance in women with GDM. This study reports decreased levels of sTWEAK in women with early pregnancy GDM, independent of age and BMI. Neither sCD163 nor sTWEAK were found to be associated to later glucose intolerance.
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| 3. |
- Jespersen, Henrik, et al.
(författare)
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Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study.
- 2019
-
Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 19:1
-
Tidskriftsartikel (refereegranskat)abstract
- While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic uveal melanoma remains a disease with an urgent unmet medical need. Reports of treatment with immune checkpoint inhibitors have thus far been disappointing. Based on animal experiments, it is reasonable to hypothesize that the effect of immunotherapy may be augmented by epigenetic therapy. Proposed mechanisms include enhanced expression of HLA class I and cancer antigens on cancer cells, as well as suppression of myeloid suppressor cells.The PEMDAC study is a multicenter, open label phase II study assessing the efficacy of concomitant use of the PD1 inhibitor pembrolizumab and the class I HDAC inhibitor entinostat in adult patients with metastatic uveal melanoma. Primary endpoint is objective response rate. Eligible patients have histologically confirmed metastatic uveal melanoma, ECOG performance status 0-1, measurable disease as per RECIST 1.1 and may have received any number of prior therapies, with the exception of anticancer immunotherapy. Twenty nine patients will be enrolled. Patients receive pembrolizumab 200mg intravenously every third week in combination with entinostat 5mg orally once weekly. Treatment will continue until progression of disease or intolerable toxicity or for a maximum of 24months.The PEMDAC study is the first trial to assess whether the addition of an HDAC inhibitor to anti-PD1 therapy can yield objective anti-tumoral responses in metastatic UM.ClinicalTrials.gov registration number: NCT02697630 . (Registered 3 March 2016). EudraCT registration number: 2016-002114-50.
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| 4. |
- Johnsson, Charlotta, et al.
(författare)
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Metacognition and Learning Journals in Higher Education
- 2013
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Ingår i: International Journal of Economics and Management Engineering. - 2226-7344. ; 3:4, s. 152-159
-
Tidskriftsartikel (refereegranskat)abstract
- The studies in higher education have its natural focus on the subject matters of study. This also holds for the master program Technology Management (TM). In addition it is important to complement the students’ academic knowledge with insights about metacognition, i.e. knowledge and understanding of themselves and their own behaviour. The introduction of so-called Learning Journals has proved to be a successful step in this direction. TM is a unique program at Lund University, where a selected number (40) of students from the Faculty of Economics (20) and from the Faculty of Engineering (20) are taught together during their last 2 years of study. Their different views on problems and challenges in today’s industry often complement each other. By the introduction of learning journals, they also learn about themselves, what influence their motivation, behaviour and attitude have on a group, and an understanding of their own preferred learning method. The learning journals are introduced in the course Project Leadership. In this course, the students are divided in groups of 4-5 students, each one managing one project. Throughout the whole course (2 semesters) the students are writing learning journals and supervisors are commenting monthly. The learning journals have four purposes; 1) providing an opportunity to reflect on the development of the project itself 2) enabling personal reflection on the own process, 2) enabling reflection on the own position and part in the group, and 4) through the longitudinal effect of the course; it provides an opportunity to compare journals over time to become aware of and able to analyse the own learning process. In a newly performed Placement report, students that have graduated from the Technology Management programme the last 10 years, rate their education 4.37 out of 5. Some students even consider the Learning Journals among the most valuable parts of the whole programme in retrospect.
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| 5. |
- Johnsson, Charlotta, et al.
(författare)
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The Usage of Learning Journals in a Technology Management Education
- 2011
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Ingår i: [Host publication title missing]. - 9781612849515 ; , s. 900-904
-
Konferensbidrag (refereegranskat)abstract
- Technology Management is a unique program at Lund University, where a selected number (40) of students from the Faculty of Economics and from the Faculty of Engineering are taught together during their last 2 years of study. Their degree will be a Master's degree. Their views on problems and challenges in today's industry often complement each other. In addition it is important to complement their academic knowledge with insights about themselves and their own behavior. The introduction of so-called Learning Journals has proved to be a successful step in this direction. The learning journals are introduced in the course Project Leadership. Throughout the whole course (2 semesters) the students are writing learning journals and supervisors are commenting monthly. The learning journals have the purpose of 1) enabling personal reflection on the own process, 2) enabling reflection on the own position and part in the group, and 3) through the longitudinal effect of the course; it provides an opportunity to compare journals over time to become aware of and able to analyze the own learning process. In a newly performed Placement report, students that have graduated from the Technology Management programme the last 10 years, rate their education 4.37 out of 5. Some students even consider the Learning Journals among the most valuable parts of the whole programme in retrospect.
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| 6. |
- Marking, Ulrika, et al.
(författare)
-
Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines
- 2022
-
Ingår i: Vaccines. - : MDPI AG. - 2076-393X. ; 10:3, s. 359-
-
Tidskriftsartikel (refereegranskat)abstract
- Heterologous primary immunization against SARS-CoV-2 is part of applied recommendations. However, little is known about duration of immune responses after heterologous vaccine regimens. To evaluate duration of immune responses after primary vaccination with homologous adeno-vectored ChAdOx1 nCoV-19 vaccine (ChAd) or heterologous ChAd/BNT162b2 mRNA vaccine (BNT), anti-spike-IgG and SARS-CoV-2 VOC-neutralizing antibody responses were measured in 354 healthcare workers (HCW) at 2 weeks, 3 months, 5 months and 6 months after the second vaccine dose. T-cell responses were investigated using a whole blood interferon gamma (IFN-gamma) release assay 2 weeks and 3 months post second vaccine dose. Two hundred and ten HCW immunized with homologous BNT were enrolled for comparison of antibody responses. In study participants naive to SARS-CoV-2 prior to vaccination, heterologous ChAd/BNT resulted in 6-fold higher peak anti-spike IgG antibody titers compared to homologous ChAd vaccination. The half-life of antibody titers was 3.1 months (95% CI 2.8-3.6) following homologous ChAd vaccination and 1.9 months (95% CI 1.7-2.1) after heterologous vaccination, reducing the GMT difference between the groups to 3-fold 6 months post vaccination. Peak T-cell responses were stronger in ChAd/BNT vaccinees, but no significant difference was observed 3 months post vaccination. SARS-CoV-2 infection prior to vaccination resulted in substantially higher peak GMTs and IFN-gamma levels and enhanced SARS-CoV-2 specific antibody and T cell responses over time. Heterologous primary SARS-CoV-2 immunization with ChAd and BNT elicits a stronger initial immune response compared to homologous vaccination with ChAd. However, although the differences in humoral responses remain over 6 months, the difference in SARS-CoV-2 specific T cell responses are no longer significant three months after vaccination.
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| 7. |
- Nilsson, Charlotta, et al.
(författare)
-
Characterisation of a pre-cell hit detector to be used in single cell irradiation experiments at the Lund Nuclear Microprobe
- 2008
-
Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - Amsterdam : Elsevier BV. - 0168-583X .- 1872-9584. ; 266:21, s. 4808-4815
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes the characterisation of an ultra-thin silicon semicondoctor Delta E detector to be used as a pre-cell ion hit detector in single ion experiments on individual, living cells. The characteristics of interest for this specific application are the hit detection efficiency, which has to be close to 100% to enable bombardment with either a single ion or a counted number of ions, the beam spreading, which should be as small as possible to maintain the targeting accuracy, and the vacuum tightness, since the detector is intended, if possible, to be used simultaneously as vacuum window. The hit detection efficiency was shown to be above 99% when detecting alpha particles or 2 MeV protons, the increase in beam size was about 1 mu m and the vacuum tightness was comparable to that of the Si3N4 wafer which is normally used as vacuum window, thus the Delta E detector fulfils the main criteria to function properly as a single ion hit detector. (C) 2008 Elsevier B.V. All rights reserved.
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| 8. |
- Nilsson, Charlotta, et al.
(författare)
-
Evaluation of a pre-cell hit detector for the future single ion hit facility in Lund
- 2006
-
Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 249:1-2, s. 924-927
-
Tidskriftsartikel (refereegranskat)abstract
- Currently, a single ion hit facility, for irradiation of single cells with single, light MeV ions is under development at the Lund Nuclear Microprobe. In this paper, a novel approach to the ion detection issue is presented. A silicon detector, a type utilized at other facilities for post-cell ion detection, has been investigated as a possible option for pre-cell hit detection. If proven successful, this detector could possibly also be used simultaneously as vacuum window. The first experiments carried out on the 9 mu m thick silicon detector, with an area of 4 mm(2), have been aimed at investigations of signal-to-noise ratio and efficiency. The results thus far reveal a low noise level and a noise distribution, which is well separated from the signal peak. However, the efficiency remains a problem, since at present it is far from the required 100%.
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| 9. |
- Olsson, Marie, et al.
(författare)
-
Utveckling av näringsladdad broccolisoppa
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Hälsosamma livsmedel är idag något som många konsumenter prioriterar när de väljer mat till måltider, och intresset är också stort för färdiga rätter. Detta projekt initierades för att öka intresset för konsumtion av broccoli, en produkt med bra hälsovärde beaktat innehåll av näringsämnen och andra nyttiga ämnen, och att möta konsumenters efterfrågan på hälsosamma färdiga rätter. Broccolisorten ’Beneforte’ valdes eftersom denna sort har en dokumenterad högre halt av glukorafanin*. Det pågår kliniska studier i Europa om hälsoeffekter av broccolisorter med hög halt av detta ämne och dessa skulle kunna leda till att ett hälsopåstående blir godkänt av EFSA, den europeiska livssäkerhetsmyndigheten. Produkter baserade på denna broccolisort skulle då kunna marknadsföras med hälsopåståendet.
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| 10. |
- Pallon, Jan, et al.
(författare)
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At the Tip of an MeV Beam: Provoking Cells and Performing Tomographic Imaging
- 2009
-
Ingår i: Acta Physica Polonica A. - 0587-4246. ; 115:2, s. 501-506
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Konferensbidrag (refereegranskat)abstract
- Biological applications of ion beams have recently become a new important research field using single ion hit facilities to study individual living cells and their response to the hit of a counted number of ions. One motivation is the search for a better understanding of the fundamental processes taking place in cells and organs as a result of irradiation. Another comes from the increasing interest in using high energy protons and heavy ions as a modality for radiotherapy of deep seated tumours. In the view of treatment efficiency, study of cell culture behaviour under controlled radiation experiments, and in different chemical environments at single ion hit facilities, is a first step towards a better understanding of the processes. Tomographic techniques are applicable to situations where you need information of the inside of an object but do not want to section it into thin slices or cannot do it. Using focused MeV ion beams for tomography restricts the sample size to the order of 10-100 mu m, depending of the initial energy. On the other hand, the ability to focus at a sub-micrometer level makes ion beams well suited for analyses of small sized objects as cells, spores, etc. The scanning transmission ion microscopy mode of tomography gives the mass density and corresponding morphological structure of holes and pores. It can then be used to correct the results from the other mode, particle induced X-ray emission tomography. Here is discussed a porosity analysis of bentonite clay that is planned to form an important buffer zone around canisters filled with spent nuclear reactor fuel waste deposited 500 m underground in Sweden.
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| 11. |
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| 12. |
- Abdel, Naseem S., et al.
(författare)
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Characterizations of new Delta E detectors for single-ion hit facility
- 2014
-
Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 318, s. 281-286
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes the performance evaluation of new Delta E detectors to be used as pre-cell hit detectors in living cell irradiation experiments at the Lund Ion Beam Analysis facility (LIBAF). Using these detectors with a thickness down to 4.15 mu m fabricated at Lund University, an experiment was setup in which Delta E-detectors were used together with a stop E-detector in a telescope system under coincidence measurements. The characteristics of Delta E detectors were based on the optimal detection of the passage of 2.55 MeV protons. The results of these tests demonstrate that the detector telescope clearly separates the protons, this due to high signal-to-noise ratio and good energy resolution of the Delta E-detectors. The best performing detector was shown to have a detection efficiency of 95% at thickness of 9.7 mu m. This type of high-performing detector is suitable for the planned role of the Delta E-detector in the future cell irradiation experiments. (C) 2013 Elsevier B.V. All rights reserved.
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| 13. |
- Abrahamsson, Victor, et al.
(författare)
-
Method development in inverse modeling applied to supercritical fluid extraction of lipids
- 2016
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Ingår i: Journal of Supercritical Fluids. - : Elsevier BV. - 0896-8446. ; 111, s. 14-27
-
Tidskriftsartikel (refereegranskat)abstract
- Modeling of the supercritical fluid extraction of solid materials is an important aspect in order to understand and predict the process. A comparison of two empirical models, two semi-empirical models and two mechanistic models is performed using calibration of single experiments. It is concluded that the best fit is obtained using a simple empirical expression. Furthermore, single calibrations did not generate reliable parameters with physical meaning and a methodology is proposed for inverse modeling with complete calibration using several experiments. The experimental dataset contained 29 extractions of lipids from crushed linseeds with varying temperatures, pressures and flow rates. A general rate model and a proposed extension of the hot ball model were evaluated for this purpose. The methodology includes data acquisition, model structure estimation, model calibration and a cross-validation. In general, it was found that the solubility model of Sovová outperformed the other evaluated correlations, and for the general rate model the Toth partition isotherm was also found in the top model structures. However, no generalization could be made regarding the correlations describing the Nernst diffusion layer and diffusivity.
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| 14. |
- Abrahamsson, Victor, et al.
(författare)
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Multicomponent inverse modeling of supercritical fluid extraction of carotenoids, chlorophyll A, ergosterol and lipids from microalgae
- 2018
-
Ingår i: Journal of Supercritical Fluids. - : Elsevier BV. - 0896-8446. ; 139, s. 53-61
-
Tidskriftsartikel (refereegranskat)abstract
- The fundamentals of analyte extractable fraction, solubility, partitioning and mass transfer resistance in supercritical fluid extraction were studied using inverse modeling. These phenomena are essential for understanding, predicting and optimizing the supercritical fluid extraction process. Carotenoids, chlorophyll A, ergosterol and total lipids were extracted from the microalgae Chlorella sp. The analytes were measured continuously in-line and on-line using UV/Vis absorption spectroscopy measurements and by evaporative light scattering detection. Various pressures, temperatures, flow rates and fractions of ethanol as a co-solvent were evaluated. The extractable fraction of carotenoids, chlorophyll A and total lipids were dependent on the co-solvent fraction in the extraction phase. The additional amount that could be extracted by using more co-solvent followed a normal distribution, indicating that analytes should not simply be categorized into weakly or strongly bound. The characteristics of diminishing extraction rates over time was accounted for by analyte partitioning rather than intra-particle diffusion limitations.
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| 15. |
- Ahnesjö, Ingrid, et al.
(författare)
-
En beteende-ekologisk forskningsperiod på Klubbans biologiska station : Rapport från återträff med Doktorer som disputerade (1983-2001) på avhandlingar med fältarbete på Klubbans Biologiska station. I en värld av kantnålar, stubbar, spiggar och nudingar.
- 2018
-
Rapport (populärvet., debatt m.m.)abstract
- We had the fortune as PhD-students and scientists in Animal Ecology at Uppsala University, to spend joyful and creative field work summers at Klubban Biological Station, during the 1980-90’s. A reunion in June 2018 resulted in this report highlighting research on pipefishes, gobies, sticklebacks and nudibranchs. Our research on these animals have provided novel insights and knowledge of the process of sexual selection and paternal care. These animals have, in many aspects, now become model organisms in evolutionary behavioral ecology in marine environments. Our list of publications provides many examples of how environmental factors influence how sexual selection and mate choice operate, how predictors like potential reproductive rates, operational sex ratios work and how male parental care is prominent in influencing selection. This research, that started at Klubban, has broadened our understanding of the ecological importance of shallow marine areas. The evolutionary understanding of how males and females can behave and how adaptive traits are selected in interaction with social and an increasingly changing ambient environment is in focus in our continued scientific endeavors. We have happily compiled this report illustrating how science and scientist can stimulate each other at a wonderful place like Klubban Biological Station, with the access to amazing organisms like pipefishes, gobies, sticklebacks and nudibranchs.
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| 16. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby
- 2015
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Ingår i: Dagens Nyheter. - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 17. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Annan publikation (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 18. |
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| 19. |
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| 20. |
- Alvehus, Johan, et al.
(författare)
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Critical theories
- 2020
-
Ingår i: Theories and perspectives in business administration. - 9789144127088 ; , s. 325-350
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 21. |
- Andreasson, Rebecka, et al.
(författare)
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HbA1c levels in children with type 1 diabetes and correlation to diabetic retinopathy
- 2018
-
Ingår i: Journal of Pediatric Endocrinology and Metabolism. - : Walter de Gruyter GmbH. - 0334-018X .- 2191-0251. ; 31:4, s. 369-374
-
Tidskriftsartikel (refereegranskat)abstract
- Type 1 diabetes mellitus (T1D) is a metabolic disease causing hyperglycemia due to β-cell destruction. Despite adequate treatment, complications such as diabetic retinopathy (DR) are common. The first aim was to investigate if acute onset of type 1 diabetes differed between those who had developed retinopathy and who had not after 15 years from diagnosis. The second aim was to investigate if mean glycosylated hemoglobin (HbA1c) levels affect the time to development of DR. The medical records of all children and adolescents diagnosed with type 1 diabetes during 1993-2001 in our area in Sweden were studied retrospectively and the mean HbA1c each year until the development of retinopathy was investigated. In total 72 patients were included and the follow-up time was between 15 and 23 years. Gender, p-glucose, age and HbA1c at diagnosis were analyzed for possible correlations to years to retinopathy. HbA1c was significantly higher among those who had developed DR after 15 years from diagnosis, 98±9.2 (n=25) vs. 86±9.2 (n=46; p=0.025). A negative correlation was found between age at diagnosis and years to DR (rs=-0.376; p=0.026). Mean HbA1c levels at years 6-10 after diabetes diagnosis correlated significantly (rs=-0.354, p=0.037) to years until retinopathy. Mean HbA1c levels at years 1-15 after diabetes diagnosis were significantly higher at years 2-3 and years 5-8 for those who had developed retinopathy after 15 years from diagnosis. Higher HbA1c levels shortened the time to development of retinopathy. It is therefore important to keep HbA1c as close to normal as possible.
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| 22. |
- Arteaga, Natalia, et al.
(författare)
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Applications of SU-8 in the development of a Single Ion Hit Facility
- 2009
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 267:12-13, s. 2117-2121
-
Konferensbidrag (refereegranskat)abstract
- The Lund Nuclear Microprobe (LNM) has been adapted to be used as a Single Ion Hit Facility (SIHF) for proton cell irradiation experiments at low dose. In order to test the capabilities of the system, Ni dot arrays and artificial cells have been fabricated with the photopolymer SU-8 and common lithographic techniques. The primary purpose of the Ni dot arrays was to determine the targeting accuracy of the beam in vacuum and in air. Additionally, this sample was employed to evaluate the system performance during cell target irradiation experiments. The Ni dot arrays were also used for beam characterization. The artificial cells were originally fabricated to test the software for cell recognition and localization, developed and implemented at the LNM. However, this sample became very functional to make small adjustments at the irradiation chamber for cell irradiation experiments. A description of the samples, fabrication procedure and applications are presented in this paper. (C) 2009 Elsevier B.V. All rights reserved.
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| 23. |
- Auzelyte, Vaida, et al.
(författare)
-
On-line measurement of proton beam current in pA range
- 2006
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 249, s. 760-763
-
Tidskriftsartikel (refereegranskat)abstract
- A MeV proton beam with a current in the range of fA-nA is usually measured using a secondary beam signal that is dependent on a sample or requires noise-free accurate charge integration in a Faraday cup. We propose a simple on-line beam current measurement setup that can be used to directly measure beam current during ion beam analysis. A fast beam blanker is used to modulate the beam position after the last set of collimator slits in and out of a mini Faraday cup connected to fA-sensitive electrometer. Less than 100 fA current can be measured during an undisturbed irradiation with kHz sampling frequency. The fast, simple and easily controlled current measurement set-up is going to be routinely used for ion beam analysis and modification at the new Lund sub-micron beam line. (c) 2006 Elsevier B.V. All rights reserved.
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| 24. |
- Bernhardsson, Christian, et al.
(författare)
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Environmental radiation baseline around the Belarusian nuclear power plant – assessments in Belarus and Lithuania
- 2023
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Ingår i: Medical Physics in the Baltic States : Proceedings of the 16<sup>th</sup> International Conference on Medical Physics - Proceedings of the 16<sup>th</sup> International Conference on Medical Physics. - 1822-5721. ; , s. 121-125
-
Konferensbidrag (refereegranskat)abstract
- Prior to the operation of the first Belarussian nuclear power plant (BelNPP), the baseline of the radiation environment was determined within a radius of about 30 km from BelNPP. This independent assessment was carried out during two expeditions in 2019. In 2022, a similar survey was carried out (during the initialoperation of BelNPP) on the Lithuanian side of the boarder. Here we present the overall project and some general results of the baseline assessments.
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| 25. |
- Bernhardsson, Christian, et al.
(författare)
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ZERO POINT ASSESSMENT OF THE RADIATION ENVIRONMENT – EXAMPLES OF A PROGRAM APPLIED IN SWEDEN (ESS) AND IN BELARUS (BELNPP)
- 2019
-
Ingår i: MEDICAL PHYSICS IN THE BALTIC STATES : Proceedings of the 14th International Conference on Medical Physics - Proceedings of the 14th International Conference on Medical Physics. ; , s. 85-88
-
Konferensbidrag (refereegranskat)abstract
- Before commissioning of a nuclear facility it is important to determine the baseline of the radiation environment. Such baseline or Zero Point assessments can only,and uniquely, be made before start of operation of the facility and will serve several purposes when the facility is in operation. Here we report on the planning and implementation of such a Zero Point program for achieving high reproducibility and effectiveness of the assessments around two nuclear installations.
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| 26. |
- Borysiuk, Maciek, et al.
(författare)
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Hydrogen analysis and profiling with a position sensitive detector
- 2013
-
Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 306, s. 49-53
-
Tidskriftsartikel (refereegranskat)abstract
- The double sided silicon strip detector (DSSSD) is a segmented silicon detector commonly used in the fields of high energy physics and nuclear physics. This type of detector is used for analysis of reactions produced by charged particles. This makes it well suited for a number of analytical methods commonly used in ion beam analysis (IBA), such as Rutherford Backscattering (RBS) and elastic recoil detection (ERDA). One such detector was installed and tested at Lund Ion Beam Analysis Facility (LIBAF) recently. This is a modification to the existing setup used to measure hydrogen concentrations and depth profiles. When completed it will be used primarily for geological applications. Exact knowledge of the hydrogen content is important in a number of fields, but high enough accuracy can be difficult to achieve with most methods. In IBA normally some variant of ERDA, such as the proton-proton (p-p) coincidence method is used. We describe how the p-p coincidence technique was optimized to get the most out of our experimental setup. Previously this type of spectroscopy has been performed with two detector channels. In the present setup we expand that number from 2 to 96 channels, 64 on the front and 32 on the back of the detector. The intersecting strips give 2048 distinct detector elements or 1024 possible coincidences as dictated by the reaction kinematics. This increase in complexity requires a more detailed data analysis but it rewards us with higher sensitivity and a better background suppression. (C) 2013 Elsevier B.V. All rights reserved.
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| 27. |
- Borysiuk, Maciek, et al.
(författare)
-
Preliminary results of oxygen isotope ratio measurement with a particle-gamma coincidence method
- 2015
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 348, s. 269-272
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Tidskriftsartikel (refereegranskat)abstract
- The possibility to study variations in the oxygen isotopic ratio with photon tagged nuclear reaction analysis (pNRA) is evaluated in the current work. The experiment described in the article was performed at Lund Ion Beam Analysis Facility (LIBAF) with a 2 MeV deuteron beam. Isotopic fractionation of light elements such as carbon, oxygen and nitrogen is the basis of many analytical tools in hydrology, geology, paleobiology and paleogeology. IBA methods provide one possible tool for measurement of isotopic content. During this experimental run we focused on measurement of the oxygen isotopic ratio. The measurement of stable isotopes of oxygen has a number of applications; the particular one driving the current investigation belongs to the field of astrogeology and specifically evaluation of fossil extraterrestrial material. There are three stable isotopes of oxygen; O-16, O-17 and O-18. We procured samples highly enriched with all three isotopes. Isotopes O-16 and O-18 were easily detected in the enriched samples, but no significant signal from O-17 was detected in the same samples. The measured yield was too low to detect O-18 in a sample with natural abundances of oxygen isotopes, at least in the current experimental setup, but the spectral line from the reaction with O-16 was clearly visible. (C) 2015 Elsevier B.V. All rights reserved.
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| 28. |
- Bosi, Ferdinando, et al.
(författare)
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Late magmatic controls on the origin of schorlitic and foititic tourmalines from late-Variscan peraluminous granites of the Arbus pluton (SW Sardinia, Italy) : Crystal-chemical study and petrological constraints
- 2018
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Ingår i: Lithos. - : Elsevier BV. - 0024-4937 .- 1872-6143. ; 308-309, s. 395-411
-
Tidskriftsartikel (refereegranskat)abstract
- Tourmalines from the late-Variscan Arbus pluton (SW Sardinia) and its metamorphic aureole were structurally and chemically characterized by single-crystal X-ray diffraction, electron and nuclear microprobe analysis, Mössbauer, infrared and optical absorption spectroscopy, to elucidate their origin and relationships with the magmatic evolution during the pluton cooling stages. The Arbus pluton represents a peculiar shallow magmatic system, characterized by sekaninaite (Fe-cordierite)-bearing peraluminous granitoids, linked via AFC processes to gabbroic mantle-derived magmas. The Fe2+-Al-dominant tourmalines occur in: a) pegmatitic layers and pods, as prismatic crystals; b) greisenized rocks and spotted granophyric dikes, as clots or nests of fine-grained crystals in small miaroles locally forming orbicules; c) pegmatitic veins and pods close to the contacts within the metamorphic aureole. Structural formulae indicate that tourmaline in pegmatitic layers is schorl, whereas in greisenized rocks it ranges from schorl to fluor-schorl. Tourmalines in thermometamorphosed contact aureole are schorl, foitite and Mg-rich oxy-schorl. The main substitution is Na + Fe2+ ↔ □ + Al, which relates schorl to foitite. The homovalent substitution (OH) ↔ F at the O1 crystallographic site relates schorl to fluor-schorl, while the heterovalent substitution Fe2+ + (OH, F) ↔ Al + O relates schorl/fluor-schorl to oxy-schorl. Tourmaline crystallization in the Arbus pluton was promoted by volatile (B, F and H2O) enrichment, low oxygen fugacity and Fe2+ activity. The mineralogical evolutive trend is driven by decreasing temperature, as follows: sekaninaite + quartz → schorl + quartz → fluor-schorl + quartz → foitite + quartz. The schorl → foitite evolution represents a distinct trend towards (Al + □) increase and unit-cell volume decrease. These trends are typical of granitic magmas and consistent with Li-poor granitic melts, as supported by the absence of elbaite and other Li-minerals in the Arbus pluton. Tourmaline-bearing rocks reflect the petrogenetic significance of contribution from a metapelitic crustal component during the evolution of magmas in the middle-upper crust.
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| 29. |
- Buli, Benti Geleta
(författare)
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Mental health problems among adolescents in Sweden : Analysis of trends, developmental trajectories, and associated factors
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis was to investigate trends and trajectories of mental health problems and associated factors among adolescents in Sweden. The project consisted of four studies, with the first presenting trends and the subsequent ones exploring influencing factors. The first two studies used data from SALVe, repeated cross-sectional surveys from 2004 – 2020, while the third used national HBSC data from 2002 – 2018. Study IV was based on data from SALVe cohorts conducted among young people born in 1997 and 1999 where data were collected in four waves every three years from 2012 – 2021. Study I investigated trends in mental health problems among adolescents in Västmanland County, revealing an overall decrease but disparities based on socioeconomic status (SES) and sex. Higher SES was associated with reduced mental health problems, while lower SES showed an increase. Girls exhibited a more pronounced decrease in depressive symptoms and suicidal ideations than boys. Study II, using the same dataset, confirmed these trends and identified school-related factors influencing mental health problems, with improvements correlating with reduced problems in the high SES group. Study III found a significant increase in PSS over time, higher in girls, and linked to lifestyle factors, particularly alcohol drunkenness among high SES adolescents. Study IV focused on cohorts born in 1997 and 1999, exploring the impact of family and peer relationships on depressive and anxiety symptoms among young people.The results indicate that intermediary factors, including school-related factors, lifestyle choices, and social relationships, which vary across SES gradients, are linked to adolescent mental health problems. The associations between these intermediary factors and the mental health problems were, in most cases, influenced by a group of factors, including SES, sex, country of origin, and birth cohort, collectively named structural determinants. These determinants discriminated results between boys and girls, high SES and low SES, Nordic and non-Nordic origin, and the 1997 and 1999 cohorts. This underscores the need for at least two-tiered policy intervention. The first involves an immediate to mid-term response, targeting these intermediary factors with a special focus on the low SES group, girls, and young people with foreign backgrounds. The second entails a long-term policy intervention to narrow the divide.
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| 30. |
- Buli, Benti Geleta, et al.
(författare)
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The impact of family and peer relationships on developmental trajectories of depressive and anxiety symptoms among young people
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Adolescent mental health is a growing global concern, with depressive and anxiety symptoms on the rise over recent decades. The significance of supportive social relationships, particularly within family and peer groups, is well-established in research. However, limited evidence exists on the impact of social relationships in predicting the developmental trajectories of mental health problems over time.Methods: This study aims to fill this gap by identifying distinct trajectories of depressive and anxiety symptoms among adolescents and exploring the impact of various factors, including family relationships, peer relationships, sex, and country of origin, on predicting individuals' likelihood of belonging to specific trajectories. Based on data collected from adolescents in Sweden born in 1997 and 1999, the study utilized Group-Based Trajectory Modeling (GBTM) to analyze longitudinal data. Statistical analyses, including multinomial logistic regression, were conducted to examine the predictive effects of social relationships on depressive and anxiety symptom trajectories.Results: Positive social relationships with family and peers emerged as robust predictors across depressive and anxiety symptom trajectories. Female participants consistently exhibited higher mean scores of depressive and anxiety symptoms than males, while participants originating from countries outside the Nordic region were at higher risk of belonging to depressive symptom trajectory groups with higher mean scores. Despite limitations such as high attrition rates, the study's methodological rigor offers valuable insights into the predictive effects of social relationships on mental health trajectories.Conclusions: The study underscores the importance of addressing social factors in adolescent mental health prevention strategies. Despite facing limitations such as high attrition rates, the study's strengths lie in its methodological rigor, providing valuable insights into the predictive effects of social relationships on mental health trajectories and addressing crucial gaps in the literature. This pioneering approach offers implications for future intervention and prevention strategies, emphasizing the importance of social factors in understanding and addressing adolescent mental health.
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| 31. |
- Buli, Benti Geleta, et al.
(författare)
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Trends in adolescent mental health problems and the role of lifestyle factors
- 2023
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background:Adolescent mental health problems are on the rise globally, including in Sweden. One indicator is an increase in psychosomatic symptoms (PSS) over time. Lifestyle factors such as physical activity (PA), diet, smoking, and alcohol consumption may influence the trends in PSS. However, we found limited research on such associations.Methods:This study is based on data collected every four years from nationally representative samples of 15-year-old boys and girls in Sweden (N = 9,196, 50.5% girls), as part of the Health Behavior in School-aged Children (HBSC) study. PSS was measured using a scale developed from the HBSC symptom checklist. We analyzed the trends in PSS from 2002 to 2018 and fitted models to investigate the associations between the trends and lifestyle factors. We included interaction terms between time and each lifestyle factor and fitted separate models for the high and low socioeconomic status (SES) groups.ResultsIn general, the mean scores for PSS increased from 2.26 in 2002 to 2.49 in 2018 (p<.001). Compared to the average mean scores during preceding years, the changes in PSS mean scores at each survey year were also significant in all years except 2010. More frequent breakfast intake, daily consumption of fruits and vegetables, and higher PA were associated with lower PSS mean scores while smoking and alcohol consumption had the opposite association. The only significant interaction (B = .050; CI: .015, ¬ .085; p<.01) was observed in the high SES group, indicating that the increasing trend in PSS was stronger among those who had been drunk once or more in a lifetime, compared to those who had never been drunk.ConclusionsThe results indicate increasing trends in mental health problems among young people in Sweden. Furthermore, the study revealed that alcohol drunkenness was associated with a more substantial rise in PSS over time among those in the high SES group. Further research is needed to understand the reasons behind these findings.
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| 32. |
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| 33. |
- Buli, Benti Geleta, et al.
(författare)
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Trends in mental health problems among Swedish adolescents : Do school-related factors play a role?
- 2024
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Ingår i: PLOS ONE. - 1932-6203. ; 19:3
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Tidskriftsartikel (refereegranskat)abstract
- AimThe aim of this study is to investigate the extent to which school-related factors, such as school liking, participation in decision-making, school-related parental support, teachers’ support, and school physical environment, explain trends in mental health problems. The problems considered are psychosomatic symptoms (PSS), depressive symptoms (DS), suicidal ideations (SI), and suicide attempts (SA) among Swedish adolescents of varying socioeconomic status (SES) from 2004 to 2020.MethodsWe analyzed data collected through repeated cross-sectional surveys from 19,873 15-year-old students at schools in a county in Sweden. Boys and girls each constituted 50% of the participants. We fitted linear and logistic regression models to investigate associations between the school-related factors and trends in mental health problems.ResultsIncreased school-related parental support and school liking were cross-sectionally associated with decreased PSS, DS and SI, with school liking also associated with decreased SA. Conducive school physical environment was also found to be cross-sectionally associated with lower PSS and DS scores. Over time, mental health problems have shown a general increase among adolescents in the low SES group and a decrease among those in the high SES group. While school-related factors explained the improvement in mental health in the high SES group, we found such association only between parental support trends in PSS and DS, along with participation and trends in SA over time among adolescents in the low SES group.ConclusionsThe results show that school-related factors play significant roles in influencing adolescent mental health. The influence, however, varied across SES gradients over time. This suggests that working against inequities in school-related factors would help address inequities in mental health.
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| 34. |
- Buli, Benti Geleta, et al.
(författare)
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Trends in psychosomatic symptoms among adolescents and the role of lifestyle factors
- 2024
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Ingår i: BMC Public Health. - 1471-2458. ; 24
-
Tidskriftsartikel (refereegranskat)abstract
- Background Adolescent mental health problems are on the rise globally, including in Sweden. One indicator of this trend is increased psychosomatic symptoms (PSS) over time. Lifestyle factors such as physical activity (PA), diet, smoking, and alcohol consumption may influence the time trends in PSS; however, the evidence base is scarce. The aim of this study was to investigate associations between time trends in PSS and lifestyle factors.Methods The study was based on data collected from a nationally representative sample of 9,196 fifteen-year-old boys and girls in Sweden using the Health Behavior in School-aged Children (HBSC) symptom checklist. The sample comprised nearly equal proportions of girls (50.5%) and boys. The lifestyle factors examined in this study included PA, regular breakfast intake, consumption of fruits, vegetables, sweets, or soft drinks, smoking, and alcohol drunkenness. We used data from 2002 to 2018 and stratified by family affluence scale (FAS) to demonstrate how the associations varied among the FAS groups. We fitted separate regression models for the high- and low-FAS groups, where interaction terms between the year of survey and each lifestyle factor were used to estimate the level and direction of associations between the factors and trends in PSS.Results There was a generally increasing trend in PSS mean scores from 2.26 in 2002 to 2.49 in 2018 (p <.001). The changes in each survey year compared to the average mean scores during the preceding years were significant in all years except 2010. Regular breakfast intake, daily fruit and vegetable consumption, and higher PA were associated with lower PSS mean scores, while smoking and drunkenness had opposite associations with PSS. The only significant interaction between survey year and the lifestyle factors was observed regarding drunkenness in the high FAS group, suggesting that the association between trends in PSS and the experience of getting drunk at least twice got stronger over time (B = 0.057; CI:0.016, 0.097; p <.01).Conclusions The results indicate increasing trends in PSS among young people in Sweden from 2002 to 2018, with a significant increase observed among adolescents in the high FAS group who reported getting drunk on at least two occasions.
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| 35. |
- De La Rosa, Nathaly, et al.
(författare)
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Lithium analysis using a double-sided silicon strip detector at LIBAF
- 2017
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 404, s. 29-33
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Tidskriftsartikel (refereegranskat)abstract
- Quantification and mapping possibilities of lithium in geological material, by Nuclear Reaction Analysis (NRA), was evaluated at the Lund Ion Beam Analysis Facility (LIBAF). LiF and two Standard Reference Materials, (SRM 610 and SRM 612) were used in the investigation. The main part of the data was obtained at the beam energy 635keV studying the high Q-value reaction 7Li(p, α)4He, but reaction yield and detection limits were also briefly investigated as a function of the energy. A double-sided silicon strip detector (DSSSD) was used to detect the α-particles emitted in the reaction in the backward direction. The combination of the high Q-value, a reasonably good cross-section and the possibility to use a high beam current have been demonstrated to allow for measurement of concentrations down below 50ppm. Proton energies below 800keV were demonstrated to be appropriate energies for extracting lithium in combination with boron analysis.
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| 36. |
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| 37. |
- de la Rosa, Nathaly, et al.
(författare)
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Quantification of lithium at ppm level in geological samples using nuclear reaction analysis
- 2018
-
Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 317:1, s. 253-259
-
Tidskriftsartikel (refereegranskat)abstract
- Proton-induced reaction (p,α) is one type of nuclear reaction analysis (NRA) suitable especially for light element quantification. In the case of lithium quantification presented in this work, accelerated protons with an energy about of 850 keV were used to induce the 7Li(p,α)4He reaction in standard reference and geological samples such as tourmaline and other Li-minerals. It is shown that this technique for lithium quantification allowed for measurement of concentrations down below one ppm. The possibility to relate the lithium content with the boron content in a single analysis was also demonstrated using tourmaline samples, both in absolute concentration and in lateral distribution. In addition, Particle induced X-ray emission (PIXE) was utilized as a complementary IBA technique for simultaneous mapping of elements heavier than sodium.
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| 38. |
- Dereke, Jonatan, et al.
(författare)
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HbA1c levels and circulating inflammatory proteins at onset of type 1 diabetes in children and adolescents
- 2022
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Ingår i: Journal of Diabetes and Metabolic Disorders. - : Springer Science and Business Media LLC. - 2251-6581. ; 21:2, s. 1427-1432
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Type 1 diabetes is an autoimmune disease that often develops during childhood. Complications such as retinopathy often occur during the course of the disease. Studies to identify possible predictors of complications in type 1 diabetes are needed; in particular markers able to identify risk of complications long before they occur. The first aim of this study was to investigate plasma levels of sCD163, sST2 and Gal-3 at diagnosis of type 1 diabetes in children and adolescents. The second aim was to study their correlation to HbA1c in this study cohort. Methods: Patients (n = 242, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital were included in this study and circulating levels of sCD163, sST2 and Gal-3 were investigated in plasma using commercially available DuoSet ELISA and supplementary ancillary kit. Results: Circulating sCD163 was significantly higher at diagnosis compared to after diagnosis (666 ± 318ng/ml and 505 ± 223ng/ml respectively; p < 0.001). Also sST2 was significantly higher (18.2 [12.7–25.6] ng/ml respectively 9.1 [6.3–13.5] ng/ml (p < 0.001), but Gal-3 levels did not differ from onset of diabetes to after diagnosis. HbA1c was shown to correlate to sCD163 (rs=0.36; p < 0.001), sST2 (rs=0.22; p = 0.016) and Gal-3 (rs=0.2; p = 0.020) in patients with a diabetes duration < 5 years. Conclusions: sCD163 levels increased in patients with recent-onset type 1 diabetes and the levels increased with higher HbA1c. Patients included in this study will be followed annually until the eventual development of diabetic complications, while continuously studying circulating levels of inflammatory proteins such as sCD163.
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| 39. |
- Dereke, Jonatan, et al.
(författare)
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IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.
- 2016
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Ingår i: Clinical Immunology. - : Elsevier BV. - 1521-6616. ; 162, s. 45-48
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Tidskriftsartikel (refereegranskat)abstract
- Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of GADA IgG4 (index=0.01 vs 0.04; p=0.03). In conclusion we found that that women with high titers of total GADA but low titers of GADA IgG4 were more prone to develop type 1 diabetes postpartum.
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| 40. |
- Dereke, Jonatan, et al.
(författare)
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The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes
- 2016
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Ingår i: Endocrine. - : Springer Science and Business Media LLC. - 1355-008X .- 1559-0100. ; 53:3, s. 740-746
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Tidskriftsartikel (refereegranskat)abstract
- The objectives were to evaluate possible associations between the SLC30A8 R325W polymorphism and gestational diabetes mellitus (GDM) as well as postpartum development of type 2 diabetes. Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific autoantibodies in postpartum development of type 1 diabetes. Women diagnosed with GDM (n = 776) and women without diabetes (n = 511) were included in the study. Autoantibodies were analyzed in all women using enzyme-linked immunosorbent assay. DNA was extracted when possible from women with GDM (n = 536) and all of the controls. R325W was detected through polymerase chain reaction and specific restriction digestion. The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes. Autoantibodies were found in 6.8 % (53/776) of the women with GDM and approximately 3.2 % (25/776) were ZnT8A positive. Approximately 19 % (10/53) of the autoantibody positive women with GDM developed postpartum type 1 diabetes. In conclusion, this is the first study to report a significant association between the R325W C-allele and increased risk of developing GDM. All of the autoantibody positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase (GADA). Thus ZnT8A did not have any additional predictive value in postpartum development of type 1 diabetes.
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| 41. |
- Ebrahimabadi, Saeed, et al.
(författare)
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Microclimate assessment method for urban design – A case study in subarctic climate
- 2018
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Ingår i: Urban Design International. - : Palgrave Macmillan. - 1357-5317 .- 1468-4519. ; 23:2, s. 116-131
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Tidskriftsartikel (refereegranskat)abstract
- Interest in climate-sensitive urban design has grown in recent decades. Nevertheless, there are various difficulties associated with such an approach. One of these is the lack of simple comfort assessment tools. This paper presents a method for microclimate assessment that is composed of a wind comfort analysis and a microclimate assessment based on measuring a combination of solar access and wind velocity. The study includes analysis of a proposed urban project situated in Kiruna, a Swedish town located in the subarctic region of the country. The results from the simulations were then overlaid to produce combined microclimate maps for three specific dates: winter solstice, spring equinox and summer solstice. The maps illustrate relative microclimate differences between areas in the proposed project based on combinations of wind/lee and sun/shadow conditions. The outcomes showed that only a small proportion of the area studied had favourable microclimate conditions at the winter solstice and spring equinox. The thermal comfort Index OUT_SET* was calculated for the summer solstice in the study area. Comparisons between the spatial distribution of OUT_SET* values and the microclimate assessment map showed a large degree of correlation. The method is intended to be a simple and representative evaluation of microclimate.
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| 42. |
- Ebrahimabadi, Saeed, et al.
(författare)
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The problems of addressing microclimate factors in urban planning of the subarctic regions
- 2015
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Ingår i: Environment and Planning, B. - : SAGE Publications. - 0265-8135 .- 1472-3417. ; 42:3, s. 415-430
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Tidskriftsartikel (refereegranskat)abstract
- Urban life in the towns of the subarctic regions is affected by the severity of the local climate, which must be taken into account in urban planning. Previous studies show that the use of climate knowledge in urban planning is hindered by different constraints. In this study we focus specifically on the problems of incorporating microclimate factors into the urban planning practices in northern Sweden. We rely on a literature study and focus on interviews as our study methods. Some of the major problems identified are the lack of design knowledge relevant to a cold climate, lack of user-friendly tools to analyze microclimate, overlooking the potential uses of local climate, and lack of support from politicians. The problems related to knowledge development and the lack of tools for microclimate analysis are discussed further. In terms of knowledge issues, the planners’ awareness of climate objectives achievable at different planning scales needs to be improved. There should be further research into the effect of urban form on the use of snow and on snow-removal activities. Tools for microclimate analysis should become more user friendly for planners. More importantly, planners need methods that combine different microclimate analyses and offer a complete assessment of a given design scheme.
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| 43. |
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| 44. |
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| 45. |
- Eckerberg, Katarina, et al.
(författare)
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Institutional analysis of energy and agriculture
- 2007. - 1
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Ingår i: Environmental policy integration in practice. - London : Earthscan Publications Ltd.. - 1844073939 - 9781844078158 - 9781849773843 ; , s. 111-136
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Bokkapitel (refereegranskat)
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| 46. |
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| 47. |
- Elfman, Mikael, et al.
(författare)
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A tailored 200 parameter VME based data acquisition system for IBA at the Lund Ion Beam Analysis Facility - Hardware and software
- 2016
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 371, s. 148-152
-
Tidskriftsartikel (refereegranskat)abstract
- With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Facility (LIBAF). The system is based on the VX-511 Single Board Computer (SBC), acting as master with arbiter functionality and consists of standard VME modules like Analog to Digital Converters (ADC's), Charge to Digital Converters (QDC's), Time to Digital Converters (TDC's), scaler's, IO-cards, high voltage and waveform units. The modules have been specially selected to support all of the present detector systems in the laboratory, with the option of future expansion. Typically, the detector systems consist of silicon strip detectors, silicon drift detectors and scintillator detectors, for detection of charged particles, X-rays and γ-rays. The data flow of the raw data buffers out from the VME bus to the final storage place on a 16 terabyte network attached storage disc (NAS-disc) is described. The acquisition process, remotely controlled over one of the SBCs ethernet channels, is also discussed. The user interface is written in the Kmax software package, and is used to control the acquisition process as well as for advanced online and offline data analysis through a user-friendly graphical user interface (GUI). In this work the system implementation, layout and performance are presented. The user interface and possibilities for advanced offline analysis are also discussed and illustrated.
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| 48. |
- Enerbäck, Charlotta, 1965, et al.
(författare)
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Stronger association with HLA-Cw6 than with corneodesmosin (S-gene) polymorphisms in Swedish psoriasis patients.
- 2000
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Ingår i: Archives of dermatological research. - : Springer Science and Business Media LLC. - 0340-3696 .- 1432-069X. ; 292:11, s. 525-30
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Tidskriftsartikel (refereegranskat)abstract
- Psoriasis vulgaris is strongly associated with certain human leukocyte antigens, especially in early onset. The purpose of this study was to study the HLA-Cw6 allele and its contribution to disease susceptibility in a set of 104 families with at least two affected siblings. A sequencing method was utilized to examine the two exons that build up the antigen binding site of the C locus receptor. DNA from patients homozygous for Cw6 based on haplotype information were sequenced. The results confirmed the identity of the Cw6 allele in affected individuals with the consensus sequence for Cw*0602. We screened the set of families for psoriasis patients homozygous for Cw6 and found 11 individuals with a mean age at onset of 16.1 years. The corresponding figure for the Cw6 heterozygotes was 18.45 years and for the Cw6-negatives 22.36 years. This is indicative of a gene dose effect. We performed a transmission disequilibrium test (TDT) on the Cw6 allele per se, used as a biallelic marker. The analysis resulted in a P-value of 5.3 x 10(-17) (t167/nt45). This greatly exceeds our previous results of a TDT in the region, including microsatellite markers and single nucleotide polymorphisms (SNPs) in the coding part of the S gene (corneodesmosin), which is a suggested candidate gene in the region. The maximum nonparametric linkage (NPL) value was also reached using HLA-C as a marker. We conclude that Cw6 is the allele which shows the highest degree of association with psoriasis in our set of families and we propose that it directly influences the age at onset of the disease rather than increasing the genetic load in accordance with a polygenic theory.
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| 49. |
- Eriksson, Cecilia, et al.
(författare)
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Microfluidic analysis of antibody specificity in a compact disk format
- 2006
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 5:7, s. 1568-1574
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Tidskriftsartikel (refereegranskat)abstract
- A new and flexible technology for high throughput analysis of antibody specificity and affinity is presented. The method is based on microfluidics and takes advantage of compact disks (CDs) in which the centrifugal force moves fluids through microstructures containing immobilized metal affinity chromatography columns. Analyses are performed as a sandwich assay, where antigen is captured to the column via a genetically attached His(6)-tag. The antibodies to be analyzed are applied onto the columns. Thereafter, fluorescently labeled secondary antibodies recognize the bound primary antibodies, and detection is carried out by laser-induced fluorescence. The CDs contain 104 microstructures enabling analysis of antibodies against more than 100 different proteins using a single CD. Importantly, through the three- dimensional visualization of the binding patterns in a column it is possible to separate high affinity from low affinity binding. The method presented here is shown to be very sensitive, flexible and reproducible.
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| 50. |
- Eriksson, Charlotta, et al.
(författare)
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Residential traffic noise exposure assessment : application and evaluation of European Environmental Noise Directive maps
- 2013
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Ingår i: Journal of Exposure Science and Environmental Epidemiology. - : Springer Science and Business Media LLC. - 1559-0631 .- 1559-064X. ; 23:5, s. 531-538
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Tidskriftsartikel (refereegranskat)abstract
- Digital noise maps produced according to the European Environmental Noise Directive (END) could provide valuable exposure information in noise and health research. However, their usefulness in epidemiological studies has not been evaluated. The objective of this study was to apply and evaluate Swedish END maps for assessments of residential traffic noise exposure. END maps from three Swedish cities were used to assess residential traffic noise exposure for a population sample of 2496 men and women included in a national Environmental Health Survey. For each subject, we assessed noise levels manually and automatically at three geographical points, using survey data to locate dwellings within buildings. Cohen's kappa coefficient (kappa) was used to assess agreement between the noise estimates. To evaluate the maps, we compared the observed and predicted proportions of annoyed residents as a function of noise exposure using survey data and already established exposure-response relationships. The root mean square deviation (r.m.s.) was used to assess the precision of observed estimates. The agreement between the noise estimates ranged from kappa = 0.4 to 0.8. Generally, there was a high correspondence between observed and predicted exposure-response relationships for noise annoyance, regardless of method and if data on dwelling location within building were used. The best precision was, however, found when we manually corrected the noise level according to the location of the dwelling within buildings (r.m.s. = 0.029). Noise maps based on the END appear useful for assessing residential traffic noise exposure, particularly if combined with survey data on dwelling location.
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