| 1. |
- Chapman, Colin D., et al.
(författare)
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Acute sleep deprivation increases food purchasing in men
- 2013
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Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 21:12
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate if acute sleep deprivation affects food purchasing choices in a mock supermarket. Design and Methods On the morning after one night of total sleep deprivation (TSD) or after one night of sleep, 14 normal-weight men were given a fixed budget (300 SEKapproximately 50 USD). They were instructed to purchase as much as they could out of a possible 40 items, including 20 high-caloric foods (>2 kcal/g) and 20 low-caloric foods (<2 kcal/g). The prices of the high-caloric foods were then varied (75%, 100% (reference price), and 125%) to determine if TSD affects the flexibility of food purchasing. Before the task, participants received a standardized breakfast, thereby minimizing the potential confound produced by hunger. In addition, morning plasma concentrations of the orexigenic hormone ghrelin were measured under fasting conditions. Results Independent of both type of food offered and price condition, sleep-deprived men purchased significantly more calories (+9%) and grams (+18%) of food than they did after one night of sleep (both P<0.05). Morning plasma ghrelin concentrations were also higher after TSD (P<0.05). However, this increase did not correlate with the effects of TSD on food purchasing. Conclusions This experiment demonstrates that acute sleep loss alters food purchasing behavior in men.
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| 2. |
- Hogenkamp, Pleunie S, et al.
(författare)
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Acute sleep deprivation increases portion size and affects food choice in young men.
- 2013
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Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 1873-3360 .- 0306-4530. ; 38:9, s. 1668-1674
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Tidskriftsartikel (refereegranskat)abstract
- Acute sleep loss increases food intake in adults. However, little is known about the influence of acute sleep loss on portion size choice, and whether this depends on both hunger state and the type of food (snack or meal item) offered to an individual. The aim of the current study was to compare portion size choice after a night of sleep and a period of nocturnal wakefulness (a condition experienced by night-shift workers, e.g. physicians and nurses). Sixteen men (age: 23±0.9 years, BMI: 23.6±0.6kg/m(2)) participated in a randomized within-subject design with two conditions, 8-h of sleep and total sleep deprivation (TSD). In the morning following sleep interventions, portion size, comprising meal and snack items, was measured using a computer-based task, in both fasted and sated state. In addition, hunger as well as plasma levels of ghrelin were measured. In the morning after TSD, subjects had increased plasma ghrelin levels (13%, p=0.04), and chose larger portions (14%, p=0.02), irrespective of the type of food, as compared to the sleep condition. Self-reported hunger was also enhanced (p<0.01). Following breakfast, sleep-deprived subjects chose larger portions of snacks (16%, p=0.02), whereas the selection of meal items did not differ between the sleep interventions (6%, p=0.13). Our results suggest that overeating in the morning after sleep loss is driven by both homeostatic and hedonic factors. Further, they show that portion size choice after sleep loss depend on both an individual's hunger status, and the type of food offered.
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| 3. |
- Nilsson, Emil, et al.
(författare)
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A low power-long range active RFID-system consisting of active RFID backscatter transponders
- 2010
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Ingår i: 2010 IEEE International Conference on RFID-Technology and Applications (RFID-TA). - Piscataway, N.J. : IEEE Press. - 9781424466986 ; , s. 26-30, s. 26-30
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a novel active radio frequency identification system consisting of transponders with low complexity, low power consumption, and long system reading range. The transponder’s low complexity and small circuit integration area indicate that the production cost is comparable to the one of a passive tag. The hardware keystone is the transponder’s radio wake-up transceiver, which is a single oscillator with very low power consumption. The communication protocol, based on frequency signalling binary tree, contributes to the low complexity of the tag architecture. More than 1500 tags can be read per second. The average transponder ID read-out delay is 319 ms when there are 1000 transponders within reach of the interrogator. The calculated expected life time for a transponder is estimated to be almost three years.
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| 4. |
- Nilsson, Emil, et al.
(författare)
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A Pharmaceutical Anti-counterfeiting Method Using Time Controlled Numeric Tokens
- 2011
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Ingår i: 2011 IEEE International Conference on RFID-Technologies and Applications. - Piscataway, NJ : IEEE Press. - 9781457700286 ; , s. 335-339
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Konferensbidrag (refereegranskat)abstract
- An anti-counterfeit and authentication method usingtime controlled numeric tokens enabling a secure logistic chain ispresented. Implementation of the method is illustrated with apharmaceutical anti-counterfeit system. The method uses activeRFID technology in combination with product seal. Authenticityis verified by comparing time controlled ID-codes, i.e. numerictokens, stored in RFID tags and by identical numeric tokensstored in a secure database. The pharmaceutical products areprotected from the supplier to the pharmacist, with thepossibility to extend the authentication out to the end customer.The ability of the method is analyzed by discussion of severalpossible scenarios. It is shown that an accuracy of 99.9% tellingthe customer she has an authentic product is achieved by the useof 11-bit ID-code strings.
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| 5. |
- Persson Lindell, Olof, et al.
(författare)
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Clinical decision support for familial hypercholesterolemia (CDS-FH) : Rationale and design of a cluster randomized trial in primary care
- 2022
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Ingår i: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 247, s. 132-148
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Tidskriftsartikel (refereegranskat)abstract
- Background: Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder with high risk of premature atherosclerotic cardiovascular disease and death. Clinical decision support (CDS) systems have the potential to aid in the identification and management of patients with FH. Prior studies using computer-based systems to screen patients for FH have shown promising results, but there has been no randomized controlled trial conducted. The aim of the current cluster randomized study is to evaluate if a CDS can increase the identification of FH.Methods: We have developed a CDS integrated in the electronic health records that will be activated in patients with elevated cholesterol levels (total cholesterol > 8 mmol/L or low-density lipoprotein-cholesterol > 5.5 mmol/L, adjusted for age, ongoing lipid lowering therapy and presence of premature coronar y arter y disease) at increased risk for FH. When activated, the CDS will urge the physician to send an automatically generated referral to the local lipid clinic for further evaluation. To evaluate the effects of the CDS, all primary care clinics will be cluster randomized 1:1 to either CDS intervention or standard care in a Swedish region with almost 500,000 inhabitants. The primary endpoint will be the number of patients diagnosed with FH at 30 months. Resource use and long-term health consequences will be estimated to assess the cost-effectiveness of the intervention.Conclusion : Despite increasing awareness of FH, the condition remains underdiagnosed and undertreated. The present study will investigate whether a CDS can increase the number of patients being diagnosed with FH.
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| 6. |
- Sundberg, Emil, 1990-, et al.
(författare)
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Low numbers of COVID-19 in Swedish pediatric oncology patients during the first pandemic year despite an open society
- 2022
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Ingår i: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 69:10
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Tidskriftsartikel (refereegranskat)abstract
- Background Sweden adopted a different strategy than many other countries to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and kept most schools open. Initial reports from China suggested that coronavirus disease 2019 (COVID-19) was milder in children compared to adults, but there was a lack of data from immunocompromised children. Therefore, we investigated the rate of verified SARS-CoV-2 infections in our Swedish pediatric oncology patients.Procedure This was a multicenter retrospective study. A questionnaire including patient data as well as SARS-CoV-2 data was sent to the six Swedish childhood cancer centers in May 2021.Results During the first pandemic year, 49 patients were identified as SARS-CoV-2 positive, and 22 (45%) children were hospitalized with COVID-19. Two children needed intensive care, but no COVID-19-related deaths were reported. Most patients (n = 36, 73%) were on active chemotherapy treatment and 23 children (49%) attended school or daycare at least part-time. Half of the SARS-CoV-2-positive patients experienced a delay in cancer treatment.Conclusions Despite the rapid spread of SARS-CoV-2 in Sweden, without a strict lockdown of the society, the number of nationally reported pediatric oncology patients with polymerase chain reaction (PCR)-verified infection was low, and the majority of children had mild disease. Our data show that treatment interruptions occurred frequently and this should clearly be avoided for the coming years.
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| 7. |
- Ygland, Emil, et al.
(författare)
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Slowly progressive dementia caused by MAPT R406W mutations : longitudinal report on a new kindred and systematic review
- 2018
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Ingår i: Alzheimer's Research & Therapy. - : BioMed Central. - 1758-9193. ; 10
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Forskningsöversikt (refereegranskat)abstract
- Background: The MAPT c.1216C > T (p.Arg406Trp; R406W) mutation is a known cause of frontotemporal dementia with Parkinsonism linked to chromosome 17 tau with Alzheimer's disease-like clinical features. Methods: We compiled clinical data from a new Swedish kindred with R406W mutation. Seven family members were followed longitudinally for up to 22 years. Radiological examinations were performed in six family members and neuropathological examinations in three. We systematically reviewed the literature and compiled clinical, radiological, and neuropathological data on 63 previously described R406W heterozygotes and 3 homozygotes. Results: For all cases combined, the median age of onset was 56 years and the median disease duration was 13 years. Memory impairment was the most frequent symptom, behavioral disturbance and language impairment were less common, and Parkinsonism was rare. Disease progression was most often slow. The most frequent clinical diagnosis was Alzheimer's disease. R406W homozygotes had an earlier age at onset and a higher frequency of behavioral symptoms and Parkinsonism than heterozygotes. In the new Swedish kindred, a consistent imaging finding was ventromedial temporal lobe atrophy, which was evident also in early disease stages as a widening of the collateral sulcus with ensuing atrophy of the parahippocampal gyrus. Unlike previously published R406W carriers, all three autopsied patients from the novel family showed neuropathological similarities with progressive supranuclear palsy, with predominant four-repeat (exon 10+) tau isoform (4R) tauopathy and neurofibrillary tangles accentuated in the basal-medial temporal lobe. Amyloid-beta pathology was absent. Conclusions: Dominance of 4R over three-repeat (exon 10-) tau isoforms contrasts with earlier reports of R406W patients and was not sufficiently explained by the presence of H1/H2 haplotypes in two of the autopsied patients. R406W patients often show a long course of disease with marked memory deficits. Both our neuropathological results and our imaging findings revealed that the ventromedial temporal lobes were extensively affected in the disease. We suggest that this area may represent the point of origin of tau deposition in this disease with relatively isolated tauopathy.
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| 8. |
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| 9. |
- Ahrentorp, Fredrik, et al.
(författare)
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Sensitive magnetic biodetection using magnetic multi-core nanoparticles and RCA coils
- 2017
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 427, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- We use functionalized iron oxide magnetic multi-core particles of 100 nm in size (hydrodynamic particle diameter) and AC susceptometry (ACS) methods to measure the binding reactions between the magnetic nanoparticles (MNPs) and bio-analyte products produced from DNA segments using the rolling circle amplification (RCA) method. We use sensitive induction detection techniques in order to measure the ACS response. The DNA is amplified via RCA to generate RCA coils with a specific size that is dependent on the amplification time. After about 75 min of amplification we obtain an average RCA coil diameter of about 1 mu m. We determine a theoretical limit of detection (LOD) in the range of 11 attomole (corresponding to an analyte concentration of 55 fM for a sample volume of 200 mu L) from the ACS dynamic response after the MNPs have bound to the RCA coils and the measured ACS readout noise. We also discuss further possible improvements of the LOD.
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| 10. |
- Almén, Markus Sällman, et al.
(författare)
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Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity
- 2014
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Ingår i: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 548:1, s. 61-67
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Tidskriftsartikel (refereegranskat)abstract
- The combination of the obesity epidemic and an aging population presents growing challenges for the healthcare system. Obesity and aging are major risk factors for a diverse number of diseases and it is of importance to understand their interaction and the underlying molecular mechanisms. Herein the authors examined the methylation levels of 27578 CpG sites in 46 samples from adult peripheral blood. The effect of obesity and aging was ascertained with general linear models. More than one hundred probes were correlated to aging, nine of which belonged to the KEGG group map04080. Additionally, 10 CpG sites had diverse methylation profiles in obese and lean individuals, one of which was the telomerase catalytic subunit (TERT). In eight of ten cases the methylation change was reverted between obese and lean individuals. One region proved to be differentially methylated with obesity (LINC00304) independent of age. This study provides evidence that obesity influences age driven epigenetic changes, which provides a molecular link between aging and obesity. This link and the identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases.
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| 11. |
- Almqvist, Erik, et al.
(författare)
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Solving the ADAPT Benchmark Problem - A Student Project Study
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper describes a solution to the Advanced Diagnosis and Prognostics testbed (ADAPT) diagnosis benchmark problem. One main objective was to study and discuss how engineering students, with no diagnosis research background, would solve a challenging diagnosis problem. The study was performed within the framework of a final year project course for control engineering students. A main contribution of the work is the discussion on the development process used by the students. The solution is based on physical models of components and includes common techniques from control theory, like observers and parameter estimators, together with established algorithms for consistency based fault isolation. The system is fully implemented in C++ and evaluated, using the DXC software platform, with good diagnosis performance.
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| 12. |
- Alvbrant, Joakim, 1973-
(författare)
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A study on emerging electronics for systems accepting soft errors
- 2016
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Moore’s law has until today mostly relied on shrinkage of the size of the devices inintegrated circuits. However, soon the granularity of the atoms will set a limit together with increased error probability of the devices. How can Moore’s law continue in thefuture? To overcome the increased error rate, we need to introduce redundancy. Applyingmethods from biology may be a way forward, using some of the strategies that transformsan egg into a fetus, but with electronic cells.A redundant system is less sensitive to failing components. We define electronic clayas a massive redundancy system of interchangeable and unified subsystems. We show how a mean voter, which is simpler than a majority voter, impact a redundant systemand how optimization can be formalized to minimize the impact of failing subsystems.The performance at given yield can be estimated with a first order model, without the need for Monte-Carlo simulations. The methods are applied and verified on a redundant finite-impulse response filter.The elementary circuit behavior of the memristor, ”the missing circuit element”, is investigated for fundamental understanding and how it can be used in applications. Different available simulation models are presented and the linear drift model is simulated with Joglekar-Wolf and Biolek window functions. Driven by a sinusoidal current, the memristor is a frequency dependent component with a cut-off frequency. The memristor can be densely packed and used in structures that both stores and compute in the same circuit, as neurons do. Surrounding circuit has to affect (write) and react (read) to the memristor with the same two terminals.We looked at artificial neural network for pattern recognition, but also for self organization in electronic cell array. Finally we look at wireless sensor network and how such system can adopt to the environment. This is also a massive redundant clay-like system.Future electronic systems will be massively redundant and adaptive. Moore’s law will continue, not based on shrinking device sizes, but on cheaper, numerous, unified and interchangeable subsystems.
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| 13. |
- Aydogdu, Canan, 1978, et al.
(författare)
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Radar Interference Mitigation for Automated Driving : Exploring Proactive Strategies
- 2020
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Ingår i: IEEE signal processing magazine (Print). - Piscataway : Institute of Electrical and Electronics Engineers (IEEE). - 1053-5888 .- 1558-0792. ; 37:4, s. 72-84
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Tidskriftsartikel (refereegranskat)abstract
- Autonomous driving relies on a variety of sensors, especially radars, which have unique robustness under heavy rain/fog/snow and poor light conditions. With the rapid increase of the amount of radars used on modern vehicles, where most radars operate in the same frequency band, the risk of radar interference becomes a compelling issue. This article analyzes automotive radar interference and proposes several new approaches that combine industrial and academic expertise toward the goal of achieving interference-free autonomous driving (AD). © IEEE.
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| 14. |
- Aydogdu, Canan, 1978, et al.
(författare)
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Radar Interference Mitigation through Active Coordination
- 2021
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Ingår i: IEEE National Radar Conference - Proceedings. - : IEEE. - 1097-5659. ; 2021-May, s. 1-6
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Konferensbidrag (refereegranskat)abstract
- Intelligent transportation is heavily reliant on radar, which have unique robustness under heavy rain/fog/snow and poor light conditions. With the rapid increase of the number of radars used on modern vehicles, most operating in the same frequency band, the risk of radar interference becomes an important issue. As in radio communication, interference can be mitigated through coordination. We present and evaluate two approaches for radar interference coordination, one for FMCW and one for OFDM, and highlight their challenges and opportunities.
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| 15. |
- Bandstein, Marcus, 1988-, et al.
(författare)
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A genetic risk score is associated with weight loss following Roux-Y gastric bypass surgery
- 2016
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Ingår i: Obesity Surgery. - : Springer Science and Business Media LLC. - 0960-8923 .- 1708-0428. ; 26:9, s. 2183-2189
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Tidskriftsartikel (refereegranskat)abstract
- Currently, Roux-en Y gastric bypass (RYGB) is the most efficient therapy for severe obesity. Weight loss after surgery is, however, highly variable and genetically influenced. Genome-wide association studies have identified several single nucleotide polymorphisms (SNP) associated with body mass index (BMI) and waist-hip ratio (WHR). We aimed to identify two genetic risk scores (GRS) composed of weighted BMI and WHR-associated SNPs to estimate their impact on excess BMI loss (EBMIL) after RYGB surgery. Two hundred and thirty-eight obese patients (BMI 45.1 +/- 6.2 kg/m(2), 74 % women), who underwent RYGB, were genotyped for 35 BMI and WHR-associated SNPs and were followed up after 2 years. SNPs with high impact on post-surgical weight loss were filtered out using a random forest model. The filtered SNPs were combined into a GRS and analyzed in a linear regression model. An up to 11 % lower EBMIL with higher risk score was estimated for two GRS models (P = 0.026 resp. P = 0.021) composed of seven BMI-associated SNPs (closest genes: MC4R, TMEM160, PTBP2, NUDT3, TFAP2B, ZNF608, MAP2K5, GNPDA2, and MTCH2) and of three WHR-associated SNPs (closest genes: HOXC13, LYPLAL1, and DNM3-PIGC). Patients within the lowest GRS quartile had higher EBMIL compared to patients within the other three quartiles in both models. We identified two GRSs composed of BMI and WHR-associated SNPs with significant impact on weight loss after RYGB surgery using random forest analysis as a SNP selection tool. The GRS may be useful to pre-surgically evaluate the risks for patients undergoing RYGB surgery.
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| 16. |
- Benedict, Christian, et al.
(författare)
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Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men.
- 2014
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Ingår i: Sleep. - : Oxford University Press (OUP). - 1550-9109 .- 0161-8105. ; 37:1, s. 195-8
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Tidskriftsartikel (refereegranskat)abstract
- To investigate whether total sleep deprivation (TSD) affects circulating concentrations of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in humans. These factors are usually found in the cytoplasm of neurons and glia cells. Increasing concentrations of these factors in blood may be therefore indicative for either neuronal damage, impaired blood brain barrier function, or both. In addition, amyloid β (Aβ) peptides 1-42 and 1-40 were measured in plasma to calculate their ratio. A reduced plasma ratio of Aβ peptides 1-42 to 1-40 is considered an indirect measure of increased deposition of Aβ 1-42 peptide in the brain.
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| 17. |
- Blom-Nilsson, Marcus, Fil. dr, et al.
(författare)
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Socionomers förutsättningar för ett systematiskt arbetssätt? : Organisatoriska hinder i arbetet med ASI Uppföljning
- 2023
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Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 100:5, s. 666-678
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Tidskriftsartikel (refereegranskat)abstract
- I det systematiserade arbetet med att följa upp hjälpbehov för personer med alkohol- eller narkotikaproblem har Addiction Severity Index uppföljnings-intervju (ASI U) en central funktion. I den här deskriptiva tvärsnittsstudien undersöker vi närmare hur demografiska, yrkesrelaterade och organisato-riska faktorer är relaterade till yrkesverksamma socionomers benägenhet att arbeta med ASI uppföljning. Studien omfattar 135 yrkesverksamma socionomer som arbetar med att utreda och följa upp hjälpbehov för personer med skadligt bruk eller beroende av alkohol eller narkotika. Bristande kompetens framträder som förenat med en lägre sannolikhet att arbeta med ASU upp-följning. För att öka medarbetares benägenhet att arbeta med ASU U bör chefer och andra personer i arbetsledande position ge medarbetare reella förutsättningar till fortbildning och vidareutbildning.
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| 18. |
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| 19. |
- Bojsen-Møller, Emil, 1989-
(författare)
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Movement Behaviors and Cognitive Health for Office Workers
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The lifetime trajectories of movement behavior and cognitive functioning depend on complex interactions between genetic and environmental factors. There is substantial evidence suggesting that physical activity benefits cognitive functions. However, how sedentary behavior and the composition of movement behaviors (i.e., sleep, physical activity, and sedentary behavior) influences cognitive functions remains to be elucidated. Observational studies suggest that sedentary time is unfavorably related to cognitive functions in older adults, but the majority of evidence comes from self-reported estimates of movement behavior, which are rather weakly related to device-based measures. Furthermore, while evidence suggests that structured exercise can have protective effects on cognition in inactive older adults, much less is known about how midlife movement behavior is related to cognitive functions. Thus, knowledge of how midlife movement behavior relates to and possibly affects cognitive functions and its underlying mechanisms is much needed. This thesis is part of a larger research project investigating how movement behaviors relate to and influence cognitive function, mental health, and neurophysiological mechanisms underpinning these. The project specifically targets healthy office workers and is co-produced with employers of office workers and health-promoting companies. This thesis aimed to investigate how movement behaviors relate to and influence cognitive functions and neuroplasticity among office workers.The first study investigated cross-sectional relationships between device-measured movement behavior and cognitive functions among 334 office workers. The results revealed no association between total time spent in moderate to vigorous physical activity or sedentary behavior and cognitive functions, suggesting that this association may not be as robust as previously suggested in older populations or as inferred from self-report. The second study investigated the extent to which corticospinal excitability is influenced by different movement behaviors. Sixteen sedentary office workers participated in a cross-over randomized controlled trial. We contrasted 3 hours of prolonged sitting with 3 hours of interrupted sitting and 2.5 hours sitting followed by a 25-minute bout of exercise. Acute changes in corticospinal excitability and long-term potentiation-like neuroplasticity were investigated using transcranial magnetic stimulation and paired associative stimulation. Changes in corticospinal excitability over time did not differ between conditions, suggesting that in inactive middle-aged office workers, a physical activity bout or frequently breaking up prolonged sitting does not induce immediate changes in corticospinal excitability or long-term potentiation-like neuroplasticity. The third and fourth studies are based on a 6-month cluster-randomized intervention conducted in 263 healthy office workers. An ecological model for behavior change was used to design two interventions aiming at reducing sedentary behavior or increasing physical activity relative to a passive control group, with the ultimate aim of improving cognitive functions and mental health. The third study investigated how effective each intervention was at changing the 24-hour movement behavior, and the fourth study examined intervention effects on cognitive functions. The results showed that the interventions were ineffective in reducing sedentary behavior and increasing physical activity, respectively, with no detected beneficial effects on cardiorespiratory fitness or cognitive functions relative to the control group. Changes in cognition from baseline to follow-up were not associated with changes in the composition of movement behaviors or cardiorespiratory fitness, but some associations between changes in movement behaviors and cognition were moderated by sex, age, and cardiorespiratory fitness. Thus, the third and fourth studies of the thesis have highlighted the challenges involved in successfully achieving movement behavior change to address the possible effects on cognitive improvements in an ecological setting.In summary, the results presented in this thesis did not provide support for an association between movement behaviors and cognitive functions in healthy physically active office workers, demonstrated no acute effect of a single session of physical activity or breaking up prolonged sitting on corticospinal excitability in sedentary office workers, and revealed no evidence for successful movement behavior change or benefits for cognition in an ecological cluster-randomized intervention in healthy physically active office workers. The findings suggest that among physically active office workers, sedentary behavior may not be as detrimental for cognition and neuroplasticity as previously suggested and shows that changing movement behavior in office workers at the workplace represents a challenging endeavor. Still, these findings do not exclude the possibility that changes in movement behaviors might benefit cognitive functions in physically inactive office workers at higher cardiovascular risk, with lower cardiorespiratory fitness and/or lower daily cognitive stimulation.
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| 20. |
- Bojsen-Møller, Emil, 1989-, et al.
(författare)
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The effect of two multi-component behavior change interventions on cognitive functions.
- 2022
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Ingår i: BMC Public Health. - : BioMed Central (BMC). - 1471-2458. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We previously reported the effects of two cluster-randomized 6-month multi-component workplace interventions, targeting reducing sedentary behavior or increasing physical activity among office workers, on movement behaviors and cardiorespiratory fitness. The primary aim of this study was to investigate the effects of these interventions on cognitive functions compared to a wait-list control group. The secondary aims were to examine if changes in cognition were related to change in cardiorespiratory fitness or movement behaviors and if age, sex, or cardiorespiratory fitness moderated these associations.METHODS: Both interventions encompassed multi-components acting on the individual, environmental, and organizational levels and aimed to change physical activity patterns to improve mental health and cognitive function. Out of 263 included participants, 139 (mean age 43 years, 76% females) completed a neuropsychological test battery and wore accelerometers at baseline and 6-month follow-up. The intervention effect (aim 1) on cognitive composite scores (i.e., Executive Functions, Episodic Memory, Processing Speed, and Global Cognition) was investigated. Additionally, associations between changes in movement behaviors and cardiorespiratory fitness, and changes in cognition were examined (aim 2). Moreover, age, sex, and cardiorespiratory fitness level were investigated as possible moderators of change associations (aim 3).RESULTS: Overall, cognitive performance improved from baseline to follow-up, but the change did not differ between the intervention groups and the control group. Changes in cardiorespiratory fitness or any movement behavior category did not predict changes in cognitive functions. The association between changes in time in bed and changes in both Executive Function and Global Cognition were moderated by age, such that a more positive relation was seen with increasing age. A less positive association was seen between changes in sedentary behavior and Processing Speed for men vs. women, whereas higher cardiorespiratory fitness was related to a more positive association between changes in moderate-intensity physical activity and Global Cognition.CONCLUSION: The lack of an intervention effect on cognitive functions was expected since the intervention did not change movement behavior or fitness. Age, sex, and cardiorespiratory fitness level might moderate the relationships between movement behaviors and cognitive functions changes.TRIAL REGISTRATION: ISRCTN92968402 . Registered 09/04/2018.
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| 21. |
- Brooks, Samantha J, et al.
(författare)
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BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:1, s. e82707-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Brain-derived neurotrophic factor (BDNF) links learning, memory and cognitive decline in elderly, but evidence linking BDNF allele variation, cognition and brain structural differences is lacking.METHODS: 367 elderly Swedish men (n = 181) and women (n = 186) from Prospective Investigation of the Vasculature in Uppsala seniors (PIVUS) were genotyped and the BDNF functional rs6265 SNP was further examined in subjects who completed the Trail Making Task (TMT), verbal fluency task, and had a magnetic resonance imaging (MRI) scan. Voxel-based morphometry (VBM) examined brain structure, cognition and links with BDNF.RESULTS: The functional BDNF SNP (rs6265,) predicted better working memory performance on the TMT with positive association of the Met rs6265, and was linked with greater cerebellar, precuneus, left superior frontal gyrus and bilateral hippocampal volume, and reduced brainstem and bilateral posterior cingulate volumes.CONCLUSIONS: The functional BDNF polymorphism influences brain volume in regions associated with memory and regulation of sensorimotor control, with the Met rs6265 allele potentially being more beneficial to these functions in the elderly.
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| 22. |
- Brooks, S. J., et al.
(författare)
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Psychological intervention with working memory training increases basal ganglia volume : A VBM study of inpatient treatment for methamphetamine use
- 2016
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Ingår i: NeuroImage. - : Elsevier BV. - 2213-1582. ; 12, s. 478-491
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Protracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known. Methods: 66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18-50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis. Results: TAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores. Conclusions: While psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.
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| 23. |
- Bååth, Lars, 1948-, et al.
(författare)
-
Method and device for multidimensional imaging
- 2007
-
Patent (populärvet., debatt m.m.)abstract
- PROBLEM TO BE SOLVED: To provide a method and system using transmission of an electromagnetic signal in order to determine the positions of reflection points by detecting the signals reflected at the reflection points in space. ; SOLUTION: The present invention provides a method, antenna, and system for defining the positions of the reflection points using microwave. The electromagnetic signal is generated at a determined frequency, and is transmitted by an antenna unit. The antenna unit comprises a transmitting antenna, and many receiving antennas that are separated at a known interval in the direction perpendicular to the main visual axis and are designed to receive a part of the reflected wave of the transmitted wave. A phase comparing means is connected to the transmitting antenna and receiving antennas, and a control unit connected to the phase comparing means can calculate an angle to the reflection points and calculate the distances to the reflection points. ; COPYRIGHT: (C)2007,JPO&INPIT
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| 24. |
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| 25. |
- Bååth, Lars, 1948-, et al.
(författare)
-
Multi-dimensional imaging method and apparatus
- 2007
-
Patent (populärvet., debatt m.m.)abstract
- A method, an antenna, and a system for determining positions for reflection points using microwaves. An electromagnetic wave signal is generated at a defined frequency, and transmitted by an antenna unit the antenna unit includes a transmitter antenna and a plurality of receiver antennas, separated by a known spacing perpendicular to a main line of sight and devised to receive reflected portions of the transmitted wave. Phase comparator means are connected to the transmitter antenna and the receiver antennas, and a control unit connected to the phase comparator means is operable to calculate an angle to a reflection point from detected phase difference between at least two receiver antennas and the spacing between said at least two receiver antennas, and to calculate a distance to the reflection point from detected phase difference between the transmitter antenna and a receiver antenna dependent on the frequency.
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| 26. |
- Carlsson Tedgren, Åsa, et al.
(författare)
-
Experience from long-term monitoring of RAKR ratios in Ir-192 brachytherapy
- 2008
-
Ingår i: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 89:2, s. 217-221
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Ratios of values of brachytherapy source strengths, as measured by hospitals and vendors, comprise constant differences as, e.g., systematic errors in ion chamber calibration factors and measurement setup. Such ratios therefore have the potential to reveal the systematic changes in routines or calibration services at either the hospital or the vendor laboratory, which could otherwise be hidden by the uncertainty in the source strength values. Methods: The RAKR of each new source in 13 afterloading units at five hospitals were measured by well-type ion chambers and compared to values for the same source stated on vendor certificates. Results: Differences from unity in the ratios of RAKR values determined by hospitals and vendors are most often small and stable around their mean values to within +/- 11.5%. Larger deviations are rare but occur. A decreasing ratio, seen at two hospitals for the same source, was useful in detecting an erroneous pressure gauge at the vendors site. Conclusions: Establishing a mean ratio of RAKR values, as measured at the hospital and supplied on the vendor certificate, and monitoring this as a function of time are an easy way for the early detection of problems with equipment or routines at either the hospital or the vendor site.
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| 27. |
- Carvajal, Gisela, 1983, et al.
(författare)
-
Comparison of Automotive FMCW and OFDM Radar Under Interference
- 2020
-
Ingår i: IEEE National Radar Conference - Proceedings. - New York, NY : IEEE. - 1097-5659. ; 2020-September
-
Konferensbidrag (refereegranskat)abstract
- Automotive radars are subject to interference in spectrally congested environments. To mitigate this interference, various waveforms have been proposed. We compare two waveforms (FMCW and OFDM) in terms of their radar performance and robustness to interference, under similar parameter settings. Our results indicate that under proper windowing both waveforms can achieve similar performance, but OFDM is more sensitive to interference.
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| 28. |
- Christoffersson, Gustaf, et al.
(författare)
-
Acute sleep deprivation in healthy young men : Impact on population diversity and function of circulating neutrophils
- 2014
-
Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 41, s. 162-172
-
Tidskriftsartikel (refereegranskat)abstract
- Lack of sleep greatly affects our immune system. The present study investigates the acute effects of total sleep deprivation on blood neutrophils, the most abundant immune cell in our circulation and the first cell type recruited to sites of infection. Thus, the population diversity and function of circulating neutrophils were compared in healthy young men following one night of total sleep deprivation (TSD) or after 8 h regular sleep. We found that neutrophil counts were elevated after nocturnal wakefulness (2.0 +/- 0.2 x 10(9)/l vs. 2.6 +/- 0.2 x 10(9)/l, sleep vs. TSD, respectively) and the population contained more immature CD16(dim)/CD62L(bright) cells (0.11 +/- 0.040 x 10(9)/l [5.5 +/- 1.1%] vs. 0.26 +/- 0.020 x 10(9)/l [9.9 +/- 1.4%]). As the rise in numbers of circulating mature CD16(bright)/CD62L(bright) neutrophils was less pronounced, the fraction of this subpopulation showed a significant decrease (1.8 +/- 0.15 x 10(9)/l [88 +/- 1.8%] vs. 2.1 +/- 0.12 x 10(9)/l [82 +/- 2.8%]). The surface expression of receptors regulating mobilization of neutrophils from bone marrow was decreased (CXCR4 and CD49d on immature neutrophils; CXCR2 on mature neutrophils). The receptor CXCR2 is also involved in the production of reactive oxygen species (ROS), and in line with this, total neutrophils produced less ROS. In addition, following sleep loss, circulating neutrophils exhibited enhanced surface levels of CD11b, which indicates enhanced granular fusion and concomitant protein translocation to the membrane. Our findings demonstrate that sleep loss exerts significant effects on population diversity and function of circulating neutrophils in healthy men. To which extent these changes could explain as to why people with poor sleep patterns are more susceptible to infections warrants further investigation.
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| 29. |
- Engström, Gunnar, et al.
(författare)
-
Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications
- 2024
-
Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 39:1, s. 35-49
-
Tidskriftsartikel (refereegranskat)abstract
- Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
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| 30. |
- Ernst, Robert, et al.
(författare)
-
60GHz Vital Sign Radar using 3D-printed Lens
- 2016
-
Ingår i: 2016 IEEE SENSORS. - Piscataway : IEEE. - 9781479982875 - 9781479982882
-
Konferensbidrag (refereegranskat)abstract
- There is an increased interest in contact-less vital sign monitoring methods as they offer higher flexibility to the individual being observed. Recent industrial development enabled radar functionality to be packed in single-chip solutions, decreasing application complexity and speeding up designs. Within this paper, a vital sign radar has been developed utilizing a recently released 60GHz frequency modulated continuous wave single-chip radar in combination with 3D-printed quasi-optics. The electronics development has been focused on compactness and high system integration using a low cost design process. The final experiments prove that the radar is capable of tracking human respiration rate and heartbeat at the same time from a distance of 1m.
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| 31. |
- Friel, Ross, Dr, 1982-, et al.
(författare)
-
3D Printed Radar Lenses with Anti-Reflective Structures
- 2019
-
Ingår i: Designs. - Basel : MDPI. - 2411-9660. ; 3:2
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose of this study was to determine if 3D printed lenses with wavelength specific anti-reflective (AR) surface structures would improve beam intensity and thus radar efficiency for a Printed Circuit Board (PCB)-based 60 GHz radar. This would have potential for improved low-cost radar lenses for the consumer product market. Methods: A hyperbolic lens was designed in 3D Computer Aided Design (CAD) software and was then modified with a wavelength specified AR structure. Electromagnetic computer simulation was performed on both the ‘smooth’ and ‘AR structure’ lenses and compared to actual 60 GHz radar measurements of 3D printed polylactic acid (PLA) lenses. Results: The simulation results showed an increase of 10% in signal intensity of the AR structure lens over the smooth lens. Actual measurement showed an 8% increase in signal of the AR structure lens over the smooth lens. Conclusions: Low cost and readily available Fused Filament Fabrication (FFF) 3D printing has been shown to be capable of printing an AR structure coated hyperbolic lens for millimeter wavelength radar applications. These 3D Printed AR structure lenses are effective in improving radar measurements over non-AR structure lenses. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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| 32. |
- Guarese, Renan, et al.
(författare)
-
A proposal for augmented situated visualization towards EMC testing
- 2020
-
Ingår i: CEUR Workshop Proceedings. - : CEUR-WS. ; , s. 12-15
-
Konferensbidrag (refereegranskat)abstract
- Copyright © 2020 for this paper by its authors.In EMC testing, 3D electromagnetic field data often needs to be visually analysed by an expert in order to detect product defects or unwanted interference between multiple devices. In this sense, the present work proposes the use of data visualization techniques allied to an Augmented Reality user interface to provide information that helps professionals to analyse the same data, however spatially situated where it was first measured. Apart from visualizing it, users may also interact with the data to narrow down their search by switching the attributes being displayed, combining them together, applying filters or changing the formatting in which data is presented. The approaches being proposed in this work will ultimately be tested against each other in comparable 2D and 3D interactive visualizations of the same data in a series of usability assessments with users to validate the solutions. The goal is to ultimately expose whether AR can help users to make more accurate decisions, particularly in EMC related tasks.
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| 33. |
- Guarese, Renan, et al.
(författare)
-
Augmented situated visualization methods towards electromagnetic compatibility testing
- 2021
-
Ingår i: Computers & graphics. - Oxford : Elsevier. - 0097-8493 .- 1873-7684. ; 94, s. 1-10
-
Tidskriftsartikel (refereegranskat)abstract
- In electrical engineering, hardware experts often need to analyze electromagnetic radiation data to detect any external interference or anomaly. The field that studies this sort of assessment is called electromagnetic compatibility (EMC). As a way to support EMC analysis, we propose the use of Augmented Situated Visualization (ASV) to supply professionals with visual and interactive information that helps them to comprehend that data, however situating it where it is most relevant in its spatial context. Users are able to interact with the visualization by changing the attributes being displayed, comparing the overlaps of multiple fields, and extracting data, as a way to refine their search. The solutions being proposed in this work were tested against each other in comparable 2D and 3D interactive visualizations of the same data in a series of data-extraction assessments with users, as a means to validate the approaches. Results exposed a correctness-time trade-off between the interaction methods. The hand-based techniques (Hand Slider and Touch Lens) were the least error-prone, being near to half as error-inducing as the gaze-based method. Touch Lens also performed as the least time-consuming method, taking in average less than half of the average time required by the others. For the visualization methods tested, the 2D ray casts presented a higher usability score and lesser workload index than the 3D topology view, however exposing over two times the error ratio. Ultimately, this work exposes how AR can help users to have better performances in a decision-making context, particularly in EMC related tasks, while also furthering the research in the ASV field. © 2020 Elsevier Ltd
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| 34. |
- Gupta, Ankit, 1988, et al.
(författare)
-
A Framework for Vehicle Lateral Motion Control With Guaranteed Tracking and Performance
- 2019
-
Ingår i: 2019 IEEE Intelligent Transportation Systems Conference, ITSC 2019. ; , s. 3607-3612
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we propose a framework to design a controller for the vehicle lateral dynamics, which guarantees to meet desired safety and performance requirement. Bounded lateral deviation from the reference trajectory is the strict safety requirement considered in this paper.The proposed control design relies on a mild assumption. That is, the trajectory planner generates a trajectory that is piece-wise clothoidal (PWC), with bounded curvature and curvature rate.Closed-loop simulations using a linear quadratic regulator (LQR) and a model predictive control (MPC) controller, developed based on the proposed framework, validates the proposed approach.
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| 35. |
|
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| 36. |
- Gåhlin, Emil, et al.
(författare)
-
Tillståndprocesser för kärnkraft : internationella lärdomar
- 2010
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det övergripande syftet med denna rapport är att analysera och jämföra den lagstiftning som kringgärdar tillståndsgivningen för (i första hand) nya kärnkraftverk i ett antal utvalda länder. Rapporten kan på så sätt bidra med ett viktigt kunskapsunderlag för att diskutera ändamålsenligheten i olika nationella processer (inklusive den svenska). Analysen i rapporten bygger till stora delar på rättsvetenskapliga undersökningar, och behandlar såväl de formella kraven på tillstånd och fysisk planering samt former för medborgar-samverkan i respektive fall. Studien fokuserar i första hand på lagstiftningens utformning i de utvalda länderna, och i begränsad omfattning på praxis. Denna juridiska ansats kompletteras dock också med ett investerarperspektiv på lagstiftningen, dvs. en analys av hur de relevant rättsreglerna kan påverka investeringsbeslut i praktiken. Arbetet bygger till stora delar på synteser av tidigare studier samt intervjuer med forskare, elbolag och myndighetsrepresentanter i Sverige och utomlands. De länder som ingår i jämförelsen är Sverige, Finland, Frankrike, Schweiz, Storbritannien, USA, Sydkorea och Kanada. Dessa länder inkluderar de som nu investerar i kärnkraft samt de som nyligen reformerat sina tillståndsprocesser under de senaste åren. Viktiga skillnader länderna emellan belyses, t.ex. frågor som det politiska inflytandet i prövningen, förhållandet mellan den nationella och lokala makten, former för medborgarsamverkan, samt den övergripande transparensen och förutsägbarheten i lagstiftningen. Ambitionen är också att studera de praktiska konsekvenserna av den rådande lagstiftningen; empiriska erfarenheter finns i en del relevanta fall.
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| 37. |
- Hagström, A. L., et al.
(författare)
-
An iterative approach to determine the refractive index of 3D printed 60GHz PLA lenses
- 2018
-
Ingår i: Proceedings of the 14th Loughborough Antennas and Propagation Conference (LAPC 2018). - Piscataway, N.J. : IEEE. - 9781785619694
-
Konferensbidrag (refereegranskat)abstract
- This paper describes an iterative approach to determine quasi-optical properties of standard 3D printer filament material to, in an inexpensive and fast way, construct focusing lenses for millimetre wave systems. Results from three lenses with different focal lengths are shown and discussed. The real part of the permittivity at 60GHz for polylactic acid (PLA) is in this paper determined to be εr=2.74. © 2018 Institution of Engineering and Technology. All rights reserved.
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| 38. |
- Hamsten, Carl, et al.
(författare)
-
Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients
- 2016
-
Ingår i: Respiratory Research. - : BioMed Central. - 1465-9921 .- 1465-993X. ; 17
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Sarcoidosis is a granulomatous systemic inflammatory disease in which more than 90 % of all patients develop pulmonary manifestations. Several gene associations have previously been described, but established and clinically useful biomarkers are still absent. This study aimed to find proteins in bronchoalveolar lavage (BAL) fluid that can be associated with the disease. Methods: We developed and performed profiling of 94 selected proteins in BAL fluid and serum samples obtained from newly diagnosed and non-treated patients with sarcoidosis. Using multiplexed immunoassays, a total of 317 BAL and 217 serum samples were analyzed, including asthmatic patients and healthy individuals as controls. Results: Our analyses revealed increased levels of eight proteins in sarcoidosis patients compared to controls. Out of these, fibronectin (FN1) and C-C motif chemokine 2 (CCL2) revealed the strongest associations. In addition, cadherin 5 (CDH5) was found to correlate positively with lymphocyte cell numbers in BAL fluid. Conclusions: Applying a high throughput proteomics screening technique, we found proteins of potential clinical relevance in the context of sarcoidosis.
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| 39. |
- Hanse, John
(creator_code:cre_t)
-
Rekonstruktion: Festen
- 2018
-
Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Rekonstruktion:Festen är ett labb som genomförs av grupperna Banditsagor (Malmö) och Skuggteatern (Umeå). Tillsammans undersöker de en form av scenkonst där publiken är aktörerna men inte behöver ta ansvar eller agera. Labbet pågår i en vecka och avslutas med två test i form av föreställningar. Det är dessa test som vi nu bjuder in till.Rekonstruktion:Festen är en rekonstruktion av ett fiktivt händelseförlopp. En fest kommer att återskapas, eller närmare bestämt, en klassåterträff. Klassen gick ut nionde klass för snart 20 år sedan, nu ska för första gången de ses igen. Hur mycket av högstadiedramatiken lever kvar? Är relationerna sinsemellan desamma? Påverkar tonårstiden vilka vi blir och vad vi gör med resten av våra liv? Vi kommer att återskapa en lägenhetsfest. Klassträffen är en fiktion och varje person i publiken kommer få representera en av personerna i den fiktiva klassen. Det är skådespelarnas uppgift är att spela rollerna åt publiken, att berätta vad de gör för handlingar och ibland vad de tänker.
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| 40. |
- Hellsten, Hans, et al.
(författare)
-
Multiple Access Radar Using Slow Chirp Modulation
- 2020
-
Ingår i: 2020 IEEE Radar Conference (RadarConf20). - New York, NY : IEEE. - 9781728189420 - 9781728189437 ; , s. 1-6
-
Konferensbidrag (refereegranskat)abstract
- The cohabitation of several radars, operating in the same frequency band, has become an essential and urgent topic as active safety systems for automotive applications are rolled out. An obvious concern is that mutual interference must be managed. Separating users in time, i.e. TDMA, achieves the required level of isolation in a straightforward way. CDMA techniques providing sufficient channel isolation are less obvious. The paper develops an alternative CDMA method, called Slow Chirp Modulation (SCM). SCM utilizes the full coherent integration time for transmission of a single aperiodic but ergodic signal, allowing target range and velocity to be retrieved but minimizing spectral occupancy. Spectral efficiency two orders of magnitude higher than for the discussed alternative methods is obtained, allowing more than a thousand non-interfering channels. Relying on indicated hardware schematics, the paper demonstrates the functionality of the novel signal processing algorithms, which are required for SCM. ©2020 IEEE
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| 41. |
- Hogenkamp, Pleunie S, et al.
(författare)
-
Sweet taste perception not altered after acute sleep deprivation in healthy young men.
- 2013
-
Ingår i: Somnologie : Schlafforschung und Schlafmedizin = Somnology : sleep research and sleep medicine. - : Springer Science and Business Media LLC. - 1432-9123 .- 1439-054X. ; 17:2, s. 111-114
-
Tidskriftsartikel (refereegranskat)abstract
- We hypothesized that acutely sleep-deprived participants would rate ascending concentrations of sucrose as more intense and pleasant, than they would do after one night of normal sleep. Such a finding would offer a potential mechanism through which acute sleep loss could promote overeating in humans.
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| 42. |
- Häggmark, Anna, et al.
(författare)
-
Proteomic Profiling Reveals Autoimmune Targets in Sarcoidosis
- 2015
-
Ingår i: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 191:5, s. 574-583
-
Tidskriftsartikel (refereegranskat)abstract
- Rationale: There is a need to further characterize the antibody repertoire in relation to sarcoidosis and potentially related autoantigens. Objectives: We investigated bronchoalveolar lavage (BAL) and serum samples from patients with sarcoidosis and healthy and diseased control subjects to discover sarcoidosis-associated autoantigens. Methods: Antigen microarrays built on 3,072 protein fragments were used to screen for IgG reactivity in 73 BAL samples from subjects with sarcoidosis, subjects with asthma, and healthy subjects. A set of 131 targets were selected for subsequent verification on suspension bead arrays using 272 additional BAL samples and 141 paired sera. Reactivity to four antigens was furthermore analyzed in 22 unprocessed BAL samples from patients with fibrosis and 269 plasma samples from patients diagnosed with myositis. Measurements and Main Results: Reactivity toward zinc finger protein 688 and mitochondrial ribosomal protein L43 were discovered with higher frequencies in patients with sarcoidosis, for mitochondrial ribosomal protein L43 especially in patients with non-Lofgren syndrome. Increased reactivity toward nuclear receptor coactivator 2 was also observed in patients with non-Lofgren syndrome as compared with patients with Lofgren syndrome. The antigen representing adenosine diphosphate-ribosylation factor GTPase activating protein 1 revealed high reactivity frequency in all sample groups but with significantly higher level of IgG reactivities in patients with sarcoidosis. Conclusions: Autoantigen reactivity was present in most BAL and serum samples analyzed, and the results revealed high interindividual heterogeneity, with most of the reactivities observed in single individuals only. Four proteins are here proposed as sarcoidosis-associated autoimmune targets and of interest for further validation in independent cohorts.
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| 43. |
- Iqbal, Amjad, et al.
(författare)
-
SIW-based frequency-adjustable antenna for IoT-based duplex wireless devices
- 2024
-
Ingår i: AEU - International Journal of Electronics and Communications. - München : Elsevier. - 1434-8411 .- 1618-0399. ; 173
-
Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a compact and frequency-adjustable/reconfigurable dielectric (DR)-loaded eighth-mode substrate integrated waveguide (EMSIW) antenna for duplex wireless communications. The miniaturization of the resonators is realized using a rectangular slot and high isolation is achieved by keeping a reasonable space between them. The proposed design is simulated using a three-dimensional (3D) full-wave simulator, then analysed with a circuit model and finally validated experimentally. Frequency-reconfigurability in the suggested antenna is achieved by placing DRs with different permittivities in the designated holes that are realized in the open-ended portion of each resonator. Consequently, the lower- and high-resonant bands can be reconfigured from 4.70 to 5.23 GHz and from 5.55 to 6.34 GHz, respectively. It is worth mentioning that both resonant band can be independently reconfigured. Moreover, the inter-resonator coupling is always lower than −23.5 dB in the bands of interest. Furthermore, the peak realized gains are always greater than 4.7 dBi in the lower frequency band and 5.5 dBi in the higher one. The suggested antenna has stable radiation properties in both bands in all frequency ranges. Hence, this design is suitable for compact reconfigurable devices due to its compactness, large frequency ranges, stable radiation patterns, and high isolation. © 2023 Elsevier GmbH
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| 44. |
- Johansson, Erika, et al.
(författare)
-
Can an ecological-transactional systems model in occupational therapy contribute to a social prescribing programme?
- 2021
-
Ingår i: Irish Journal of Occupational Therapy. - : Emerald Group Publishing Limited. - 0791-8437. ; 49:2, s. 115-118
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: The spread and level of loneliness is today considered a public health issue. Attempts to promote or reduce the level of loneliness have been made, one of which is social prescribing (SP), developed and extensively used. Complex interventions such as SP are advised to be connected to theory.Design/methodology/approach: For this purpose, the Person-Environment-Occupation-Participation model (PEOP) will be reviewed and used as an example, both as a way of organize occupational knowledge and as a model for practice.Findings: Occupational therapy underpinned by transactional system theory such as the PEOP model seems to give comprehensive and relevant support in the SP process. Particularly, this model can guide practitioners through crucial phases when assessing needs, matching interests and goals with relevant occupations, as well as understanding of important components embedded in the program.Originality/value: This opinion piece offers insights in why and how specific components connected to SP needs to be understood by theory and applied by personnel to facilitate a meaningful and sustainable occupational performance for the individuals.
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| 45. |
- Johansson, Erika, et al.
(författare)
-
Let’s Try Social Prescribing in Sweden (SPiS) : an Interventional Project Targeting Loneliness among Older Adults Using a Model for Integrated Care: A Research Protocol
- 2021
-
Ingår i: International Journal of Integrated Care. - : Ubiquity Press. - 1568-4156. ; 21:2
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Loneliness and social isolation among older adults (≥65) are an emerging issue of public concern, associated with increased morbidity and mortality. Today there is no systematic intervention developed, implemented or evaluated in Sweden addressing loneliness. The overall aim for this project is to develop, test and refine a person-centred Swedish model for social prescribing (SPiS), and to assess whether and how it reduces loneliness, promotes health and improves well-being among older adults.Description: The focus will be to develop, culturally adapt, evaluate and refine the SPiS model. Following the sequential structure of realist evaluation in three consecutive phases qualitative and quantitative data along with subsequent analysis methods will be collected and utilized. The project will provide knowledge of what works with the social prescribing model, for whom, in what conditions and why, in relation to loneliness, health and well-being among older adults.Discussion: SPiS has the unique position of providing initial knowledge regarding how to reduce loneliness in the Swedish context. However, evaluation is complex as this research goes beyond the unidimensional question “Is it working?”.Conclusion: Developing, implementing and evaluating such a complex program needs systematic and close evaluation.
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| 46. |
- Klintberg, Emil, 1989, et al.
(författare)
-
A primal active-set minimal-representation algorithm for polytopes with application to invariant-set calculations
- 2018
-
Ingår i: Proceedings of the IEEE Conference on Decision and Control. - 2576-2370 .- 0743-1546. ; 2018-December, s. 6862-6867
-
Konferensbidrag (refereegranskat)abstract
- This paper provides a description of a practically efficient minimal-representation algorithm for polytopes. The algorithm is based on a primal active-set method that heavily exploits warm-starts and low-rank updates of matrix factorizations in order to reduce the required computational work. By using a primal active-set method, several nonredundant inequalities can be identified for each solved linear program. Implementation details are provided both for the minimalrepresentation algorithm and for the underlying active-set method.
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| 47. |
- Klintberg, Emil, 1989, et al.
(författare)
-
Tree-Structured Polyhedral Invariant Set Calculations
- 2020
-
Ingår i: IEEE Control Systems Letters. - 2475-1456. ; 4:2, s. 426-431
-
Tidskriftsartikel (refereegranskat)abstract
- This letter provides a description of how hierarchical dependencies between inequalities can be exploited in order to efficiently calculate polyhedral approximations of maximal robust positive invariant sets using geometrically motivated methods. Due to the hierarchical dependencies, the calculations of preimage sets and minimal representations can be alleviated. It is also shown that as a byproduct from the calculations of minimal representations, a stopping criterion is obtained, which means that the commonly used subset test is superfluous.
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| 48. |
|
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| 49. |
- Kristensson, Elias, et al.
(författare)
-
Stray light suppression in spectroscopy using periodic shadowing
- 2014
-
Ingår i: Optics Express. - 1094-4087. ; 22:7, s. 7711-7721
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Tidskriftsartikel (refereegranskat)abstract
- It is well known that spectroscopic measurements suffer from an interference known as stray light, causing spectral distortion that reduces measurement accuracy. In severe situations, stray light may even obscure the existence of spectral lines. Here a novel general method is presented, named Periodic Shadowing, that enables effective stray light elimination in spectroscopy and experimental results are provided to demonstrate its capabilities and versatility. Besides its efficiency, implementing it in a spectroscopic arrangement comes at virtually no added experimental complexity. (C) 2014 Optical Society of America
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- Kristensson, Elias, et al.
(författare)
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Stray light suppression in spectroscopy using periodic shadowing
- 2014
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Ingår i: Optics Express. - : Optica Publishing Group. - 1094-4087. ; 22:7, s. 7711-7711
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Tidskriftsartikel (refereegranskat)abstract
- It is well known that spectroscopic measurements suffer from an interference known as stray light, causing spectral distortion that reduces measurement accuracy. In severe situations, stray light may even obscure the existence of spectral lines. Here a novel general method is presented, named Periodic Shadowing, that enables effective stray light elimination in spectroscopy and experimental results are provided to demonstrate its capabilities and versatility. Besides its efficiency, implementing it in a spectroscopic arrangement comes at virtually no added experimental complexity.
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