| 1. |
- Nilsson, Maria, 1957-
(författare)
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Promoting health in adolescents : preventing the use of tobacco
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There is a robust evidence base for the negative health effects from smoking. Smoking is linked to severe morbidity and to mortality, and kills up to half of its regular users. Tobacco use and production also bring other negative consequences such as economic loss for countries, poverty for individuals, child labour, deforestation and other environmental problems in tobacco growing countries. A combination of comprehensive interventions at different levels is needed to curb the tobacco epidemic. Tobacco control strategies at national levels in the western world often include components of information/education, taxation, legislative measures and influencing public opinion. Two approaches have dominated at the meso and micro levels: cessation support for tobacco users and prevention activities to support young people refraining from tobacco use. Smoking uptake is a complex process that includes factors at the societal level as well as social and individual characteristics. At national level, taxation and legislation can contribute to a societal norm opposing tobacco and creating a context for primary prevention aimed at tobacco free youth. There is no magic bullet in primary prevention. At the meso and micro levels, a continued development of knowledge on the underlying mechanisms and primary prevention methods is essential to prevent young people from starting to use tobacco. The overall aim of this thesis was to gain knowledge about factors that influence young people’s use of tobacco and of preventive mechanisms. The specific aims included to study the relation between Tobacco Free Duo, an intervention program targeting youth in Västerbotten County, and tobacco use prevalence. A specific interest was to explore the role adults can play in supporting young people to refrain from tobacco use. The thesis is based on four studies with three separate sets of data, two were quantitative and one was qualitative. The studies were conducted among adolescents (aged 13-15 yr) in Västerbotten County and on national level in Sweden (aged 13, 15 and 17 yr). Tobacco Free Duo is a school-based community intervention that started in 1993. An essential component of the intervention was to involve adults in supporting adolescents to stay tobacco free. Results showed decreased smoking in adolescents among both boys and girls in the intervention area during the study period of seven years. There was no change in a national reference group during the same time period. A bonus effect was a decrease in adult tobacco use in the intervention area. One out of four adults who supported a young person taking part in the intervention stopped using tobacco. In a qualitative assessment of young smokers, starting to smoke was described as a means of gaining control of their feelings and their situation during early adolescence. They expected adults to intervene against their smoking and claimed that close relations with caring adults could be a reason for smoking less or trying to quit smoking. In a quantitative study that used three decades of national data, over time adolescents became more positive toward parental action on children’s smoking. The adolescents strongly supported the idea of parental action, regardless of whether or not they themselves smoked. Adolescents preferred that actions from parents were dissuading their children from smoking, not smoking themselves, and not allowing their children to smoke at home. These results suggest that the Tobacco Free Duo program contributed to a reduction in adolescent smoking among both boys and girls. Using a multi-faceted intervention that includes an adolescent-adult partnership can decrease adolescent smoking uptake. Engaging adults as partners in tobacco prevention interventions that target adolescents has an important tobacco reducing bonus effect in the adults. The intervention has proven sustainable within communities. A growing majority of adolescents support parental interventions to help them refrain from tobacco. The findings dismiss the notion that adolescents ignore or even disdain parental practices concerning tobacco. A common and consequent norm against tobacco from both schools and parents using a supportive attitude can prevent tobacco use in young people.
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| 2. |
- Fagerberg, Jesper, 1976-
(författare)
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Occupational Fraud : Auditors’ Perceptions of Red Flags and Internal Control
- 2008
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose of this thesis is to increase the understanding of auditors’perceptions of occupational fraud. The focus is limited to red flags andinternal control, i.e. to the indications or symptoms of occupational fraud andthe internal control systems which are implemented in order to detect andprevent such actions from being carried out.The thesis is based on 33 interviews with auditors and experts. In order toincrease confidence, triangulation was applied which implied both aqualitative as well as a quantitative methodological approach. The collecteddata was in turn analysed through two models of analysis – an adjustedversion of the so called fraud triangle and the so called COSO-model. Theanalysis was carried out on the group of auditors as a whole (including subgroupsof auditors) as well as compared to a group of experts on fraud andoccupational fraud.The results from the study indicate several aspects of interest regardingauditors’ perceptions of occupational fraud. First, the results indicate a tendencyamong auditors to emphasise “harder” aspects stronger than “softer”aspects. Seen from the fraud triangle, this was manifested by an emphasis onopportunity; when concerning internal control of control activities in theCOSO model, this was emphasised relatively stronger. Second, the resultsindicate a rather strong heterogeneity among auditors in their perceptions ofoccupational fraud. Third, all subparts of the applied models were seldomcovered on an individual basis. Fourth, the interconnection between harderand softer sides, both concerning red flags and internal control, were not verystrongly emphasised. The results were given additional strength from thecomparison with the group of experts.The study also included a comparison among different subgroups of auditors.The subgroups were constructed based on accumulated working experience aswell as whether the respondents primarily audit larger or smaller companies.The results that were based on years of experience indicate a tendency amongolder auditors with more accumulated working experience to emphasise softeraspects relatively stronger, than auditors with less working experience. Thistendency was present for red flags as well as for internal control. More experienced auditors also demonstrated a tendency to emphasise a relativelylarger part of the two applied models of analysis. The division based on sizeof audited companies indicated similar tendencies as were found for bothmore and less experienced auditors. Hence, auditors who mainly audit largercompanies showed a tendency to emphasise softer aspects relatively strongercompared to auditors who mainly audit smaller companies.
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| 3. |
- Hultin, Kim, 1976-
(författare)
-
Primary Marine Aerosol Production : Studies using bubble-bursting experiments
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aerosol particles affect the Earth’s climate, although their impact is associated with large uncertainties. Primary marine aerosol represents a significant fraction of the global aerosol budget considering the Earth’s 70-percentage coverage by oceans. They are produced when bubbles burst at the ocean surface and can consist of sea salt, organic matter and bacteria. An experimental approach was here used to investigate the primary marine aerosol production from the bubble-bursting mechanism using water from four different geographical locations. The main findings include: Similar and stable aerosol number size distributions at all locations, centered close to 0.2 μm. Largely varying aerosol organic fractions, both with size and location. Clear tendency for increased water temperature to negatively influence the aerosol production. No covariance between surface water chlorophyll α and aerosol production on a 10-minute time scale, although decreased aerosol production was observed at times of elevated phytoplankton activity on longer time scales. Mainly external mixtures of sea salt and organics was observed. A high tendency for colony-forming marine bacteria to use bubble-bursting to reach the atmosphere. A clear diurnal cycle in aerosol production was found for both laboratory produced aerosol and in-situ aerosol fluxes, probably biologically driven. The first near coastal sea spray fluxes with limited fetch and low salinity. While the primary marine aerosol spectral shape is stable, emission concentration varies with environmental parameters. Above that, the organic fraction of the aerosol varies largely between locations. This shows that observations of primary marine aerosol emissions not necessarily can be applied to large time- or spatial scales.
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| 4. |
- Nilsson, Erik A. A., 1986-
(författare)
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Degradation Mechanisms of Heat Resistant Steel at Elevated Temperatures : In an Iron Ore Pelletizing Industry
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis focuses on the different degradation mechanisms of the stainless steel in a travelling grate in a Grate-Kiln iron ore pellet indurator. The travelling grate is a conveyor belt that transports green-body pellets to a rotary kiln while the pellets are being dried and pre-heated to a temperature of 900-1100 °C by recycled hot air. After unloading of the pellets to the rotary-kiln for further sintering, the travelling grate is cooled in room temperature while returning to the loading zone of the wet pellets.The steel was tested during thermal cycling in a test-rig, in order to simulate the influence of thermo mechanical fatigue and oxide spallation. The influence of erosion-deposition was investigated in a modified horizontal industrial combustion kiln at 800 °C, with slag and coal from production used as erosive media and combustion fuel, respectively. The influence of minor alloying additions of Mn, Si and Ti on the microstructure was explored by eight different casted alloy compositions. Isothermal heat treatments were performed at 800 °C during 200 hours on steel immersed in deposits recovered from a travelling grate in production.The three main degradation mechanisms found in this work are thermal spallation, erosion-deposition and deposit induced accelerated corrosion (DIAC). Thermal spallation of the oxide layer is caused by the thermal expansion difference between the oxide and the metal during heating and cooling. It has been found that Ti improves the spallation resistance while Si reduces it. Spallation of deposits is another cause believed to increase the degradation. Erosion-deposition appears due to simultaneous erosion and deposition of particles on the travelling grate that causes erosion or deposition depending on the amount of alkali metals in the environment. The velocity of the particles also influences erosion and deposition in the way that higher velocities increase erosion. DIAC is proposed to form on the travelling grate due to the concentration of chloride- and sulphate containing alkali metals in the deposits. Other than these major degrading mechanisms, minor degradation mechanisms such as internal oxidation, sigma formation, carburization and sensitization towards inter-granular attack have been found inside the steel during heating. Thermo mechanical fatigue (TMF) causes intergranular cracks in the material of the travelling grate. Casting issues such as micro-segregation have also been addressed in this thesis.A few different ways to improve degradation resistance have been proposed, such as homogenization heat treatments, optimization of process parameters and inhibitor solutions.
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| 5. |
- Nilsson Jannesson, Erik B, 1979-
(författare)
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Strategi, styrning och konkurrenskraft : En longitudinell studie av Saab AB
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Att skapa sammanhängande koncern-, affärs- och funktionsstrategier (strategisk kongruens), samt ett styrsystem med ett samstämmigt informationsflöde i och mellan de centrala styrverktygen (integrerad styrning), har sedan länge hävdats vara centralt för koncerners konkurrenskraft. I den mängd empiriska studier som legat till grund för detta har främst en eller två organisatoriska nivåer fokuserats när relationerna mellan strategier, styrning och konkurrenskraft diskuterats. Studier som tar ett helhetsgrepp om dessa samband efterfrågas därför för att öka kunskapen om och förståelsen av sambanden. Föreliggande avhandling svarar mot den efterfrågan.En longitudinell fallstudie för perioden 1995–2007 har genomförts. Strategier, ekonomistyrning och produktionsstyrning på koncern-, affärs- och funktionsnivå har studerats inom försvars- och säkerhetskoncernen Saab AB. Tre affärsenheter har studerats i detalj: Saab Aerosystems, Saab Bofors Dynamics och Saab Systems. Det empiriska materialet har samlats in genom 74 intervjuer med totalt 54 respondenter samt via både internt och publikt skriftligt material.Avhandlingen visar att strategisk kongruens och integrerad styrning skapas genom ömsesidig anpassning av strategier och styrning på koncern-, affärs- och funktionsnivå. Genom en sådan ömsesidighet anpassas styrningen till koncernens kritiska framgångsfaktorer och ett integrerat informationsflöde skapas. Inom Saab har detta i sin tur påverkat beteendet på alla nivåer och bidragit till att det förändrats i enlighet med strategierna. De senare har därmed implementerats. Samtidigt som dessa beteendeförändringar skett har Saabs konkurrenskraft varit god. Då implementerade strategier, anpassade utifrån omgivningen, kan antas vara en viktig del i ett företags framgång har Saabs strategiska kongruens och integrerade styrning rimligen haft en väsentlig betydelse för koncernens konkurrenskraft.
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| 6. |
- Nilsson, Sara, 1990-
(författare)
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How requirements development could support design of effective and resource-efficient offerings
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- What a company offers its customers has to fulfil several different needs, desires, constraints, which can originate from multiple different sources that affect the offering throughout its life cycle. All these criteria have to come together and be translated into statements that can support the designer’s understanding of the offering’s purpose. This translation is done through a requirements development process to provide a controlled process to define statements that describe what the offering is supposed to fulfil.This research provides insights on key challenges and success factors in requirements development to support the design of effective and resource-efficient offerings. Namely, it identifies crucial sources and aspects to be considered, and a requirements development process demonstrating how to overcome identified challenges. By getting the requirements right from the beginning, sub-optimisation and unnecessary time and risks can be avoided. The consideration of accurate sources and aspects is considered to be one of the most important factors for the successful design of offerings. It is also in the earliest phases of design, that is to say requirements development, where one has the greatest possibility to affect the environmental impact of the offering. What is missing, however, is sufficient and appropriate support in industry on how to do so.The gap between the three areas of effectiveness and resource efficiency, design of integrated offerings, and requirements development has been investigated. Results are based on findings in the literature and in industry, identified primarily by qualitative studies. In the research, 15 different companies have been included through a number of interviews and discussions.Key sources and aspects to consider in the requirements development process are identified along with challenges, and success factors that can be utilised to overcome the identified challenges. This research’s final results include an adapted requirements development process that considers the earlier-mentioned sources and aspect, challenges, and success factors. Such a requirements development process should support the design of effective and resource-efficient offerings.
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| 7. |
- Folkersen, Lasse, et al.
(författare)
-
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
- 2020
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Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
-
Tidskriftsartikel (refereegranskat)abstract
- Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
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| 8. |
- Henricson, Joakim, 1977-
(författare)
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Assessment of microvascular effects of vasoactive drugs : Methodological in vivo studies in humansbased on iontophoresis
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cardiovascular disease is the leading cause of death in western societies and endothelial dysfunction is one of the earliest signs seen in the development of such conditions. Thedevelopment of prognostic tools to aid in the prediction of micro- and macrovascular diseasebased on assessment of vascular reactivity is therefore of paramount importance.Transdermal iontophoresis offers a quick, non-invasive and relatively straightforward way todeliver vasoactive substances in order to provoke a vascular response in man. When combined with either laser Doppler flowmetry (LDF) or tissue viability imaging (TiVi) for quantification of these responses the methodology offers a potentially powerful tool forvascular investigations. The technique has, however, not been established in clinical practice yet and is mostly used in experimental settings. The lack of consensus in what data analysistechnique to use, uncertainty concerning the actual drug dose applied, and the difficulties associated with the assessment of responses to vasoconstrictors may have contributed to thisfact. The aim of this thesis is therefore to address these issues and thus facilitate the use and improve the applicability of transdermal iontophoresis for assessment of cutaneous microvascular function.More specifically, a non-linear dose-response model (Emax-model) that is commonly used in in vitro investigations of vascular function was applied to the iontophoresis data. The resultsshow that the Emax-model accurately describes the cutaneous vascular responses totransdermally iontophoresed acetylcholine (ACh) and, sodium nitroprusside (SNP). The Emaxmodelgenerates variables that can be used for quantitative statistical analysis of data andenables a more powerful analysis compared to the methods presently used. It is furtherdemonstrated that the maximal dose effect and vascular responses vary between differentprotocols with the same total iontophoretic charge but with different current strengths anddurations. This finding implies that the assumption that the local drug dose is linearlyproportional to the iontophoretic charge (used for estimation of delivered drug dose to themicrovascular bed) may be inaccurate in in vivo investigations and that there is need for amore refined model.It is also demonstrated that in a vasoconstrictive setting (iontophoresis of noradrenaline andphenylephrine) TiVi is the favourable technique for measuring vascular responses as it issensitive enough to generate data that can be fitted to the Emax-model even without predilatationof the vessels.
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| 9. |
- Karlsson, Markus
(författare)
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Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Oxidative stress is a major pathogenic factor in the development of age-related macular degeneration (AMD), which is the most common cause of severe central visual impairment in the elderly population in the western world.It is believed that the degenerative process starts in the retinal pigment epithelium (RPE). The post-mitotic RPE is a single layer of pigmented cells located behind the photoreceptors – rods and cones – of the retina. Daily, the RPE cells phagocytose and recycle the expended tips of the photoreceptor outer segments. This heavy phagocytic burden leads to substantial oxidative stress in the cells, which is further enhanced by intense illumination and a high oxygen tension. A hallmark of early AMD is a progressive build-up of the non-degradable age pigment lipofuscin (LF) in lysosomes of the RPE. LF accumulation hampers phagocytosis and autophagy in the RPE, resulting in increased amounts of cellular debris in and around the cells. This decreases the function and viability of both RPE cells and photoreceptors.Iron is known to accumulate in the retina with increasing age, particularly in AMDaffected eyes, and amplifies oxidative stress by acting as a potent catalyst in the generation of hydroxyl radicals. These highly reactive radicals contribute to LF formation and may, if abundantly present, also directly damage lysosomal membranes. The subsequent leakage of degrading enzymes to the cytosol initiates cell death via apoptosis or necrosis.In this thesis, we have investigated the oxidative stress response of human RPE (ARPE-19) cells compared to murine J774 cells, another type of lysosome-rich cells with a high phagocytic capacity. The ARPE-19 cells were found to be extremely resistant to oxidative stress and tolerated exposure to single doses of H2O2 in concentrations up to 150 times higher than the J774 cells before lysosomal rupture and ensuing cell death occurred. This resistance was increased even further when the cells were protected with a potent iron chelator that prevents redox-active iron to participate in hydroxyl radical generation. Both cell lines were shown to be equally effective in degrading H2O2 and seem to contain comparable amounts of total as well as intralysosomal iron. Therefore, we reasoned that the insensitivity of ARPE-19 cells to H2O2 exposure might be related to a mechanism which keeps their intralysosomal iron bound in a non redox-active form. This theory was supported by our finding of very high basal expression levels of metallothionein (MT), heat shock-protein 70 (HSP70) and ferritin (FT) in ARPE-19 cells compared to J774 cells. All of these proteins have previously been shown to possess potent iron-binding properties. The ARPE-19 cells were also shown to have a higher basal rate of autophagy. SiRNA-mediated attenuation of MT, HSP70 and FT levels in the ARPE-19 cells resulted, to some degree, in an increased sensitivity to H2O2 treatment. Furthermore, a human cell stress array showed several other stress-related proteins to be up-regulated in ARPE-19 cells.Additionally, we evaluated the commonly used, but frequently misinterpreted, H2DCF test for oxidative stress. It was demonstrated that oxidation of H2DCF into fluorescent DCF mainly reflects relocation to the cytosol of lysosomal iron and mitochondrial cytochrome c, rather than being the result of some poorly defined “general” oxidative stress.In conclusion, our results indicate that the extreme resistance to oxidative stress exhibited by the ARPE-19 cells might be related to a high continuous autophagic influx of iron-binding proteins into the lysosomal compartment. Before being degraded, such proteins will temporarily keep intralysosomal iron bound in a non redox-active form, thereby inhibiting hydroxyl radical formation. This may partly explain why RPE cells, in spite of their exposed location and heavy burden of phagocytosis, usually manage to survive and evade significant LF accumulation until late in life.
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| 10. |
- Nilsson, Lars-Erik, 1949-
(författare)
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"But can't you see they are lying" : student moral positions and ethical practices in the wake of technological change
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Today it is considered important that modern digital technology be implemented and that all citizens learn to use it. Students already use mobile phones, personal digital assistants, computers, and their applications to do much of their work. This includes searching for and retrieving information, and collaborating on assignments and writing. Recently, claims have been made in both the media and academic research that student technology use is an important factor underlying an increase in student attempts to deceive on exams and other graded work. For example, it is assumed that students sometimes use the Internet to download other people’s essays, then handing them in as their own, and to make patchwork compositions of other people’s texts using the copy and paste functions. Such claims, however, risk not considering other changes that have occurred, for example, changing forms of exams/assessed assignments. Accordingly, one aim of this thesis has been to go beyond the categorization of students as cheaters and their use of digital technology as the use of unauthorized aids when discussing student use of technology in exams/graded assignments, and consider what rights and duties and what other subject positions are being made available for them. Four studies have been conducted, the first into the work of high-school students on research reports and the other three into interaction in disciplinary inquiries. These studies illustrate how exams/graded assignments and assessment in general introduce dilemmas for students and how it is important to consider how these dilemmas are solved in practice before making assumptions about technology use as cheating. As a contribution to the debate about students’ moral values and their use of technology, this work has demonstrated the importance of distinguishing between actions and the meaning ascribed to them as acts. A general observation is that student use of technology is generally met with suspicion. Cheating functions as a device for making good texts appear as possible downloads, texts with uneven quality as possible patchwork, inadvertent textual overlaps (i.e., unintentional near reproduction of the wording of a source) as intentional plagiarism, and student references to technical problems as probable rationalizations. From a methodological perspective, the utility of investigating cheating as an interactional accomplishment is demonstrated. This approach has made it possible to investigate how students reason about using existing texts and asking others for help. As well, the application of a dynamic perspective on subjectivity has made a theoretical contribution. Through this perspective, it is possible to criticize the normalization of students as cheaters based on how they use technology. That their actions could as easily make other positions available to them is shown.
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| 11. |
- Nilsson, Susanna, 1978-
(författare)
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Augmentation in the Wild : User Centered Development and Evaluation of Augmented Reality Applications
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Augmented Reality (AR) technology has, despite many applications in the research domain, not made it to a widespread end user market. The one exception is AR applications for mobile phones. One of the main reasons for this development is technological constraints of the non-mobile phone based systems - the devices used are still neither mobile nor lightweight enough or simply not usable enough. This thesis addresses the latter issue by taking a holistic approach to the development and evaluation of AR applications for both single user and multiple user tasks. The main hypothesis is that in order for substantial wide spread use of AR technology, the applications must be developed with the aim to solve real world problems with the end user and goal in focus.Augmented Reality systems are information systems that merge real and virtual information with the purpose of aiding users in different tasks. An AR system is a general system much like a computer is general; it has potential as a tool for many different purposes in many different situations. The studies in this thesis describe user studies of two different types of AR applications targeting different user groups and different application areas. The first application, described and evaluated, is aimed at giving users instructions for use and assembly of different medical devices. The second application is a study where AR technology has been used as a tool for supporting collaboration between the rescue services, the police and military personnel in a crisis management scenario.Both applications were iteratively developed with end user representatives involved throughout the process and the results illustrate that users both in the context of medical care, and the emergency management domain, are positive towards AR systems as a technology and as a tool in their work related tasks. The main contributions of the thesis are not only the end results of the user studies, but also the methodology used in the studies of this relatively new type of technology. The studies have shown that involving real end users both in the design of the application and in the user task is important for the user experience of the system. Allowing for an iterative design process is also a key point. Although AR technology development is often driven by technological advances rather than user demands, there is room for a more user centered approach, for single user applications as well as for more dynamic and complex multiple user applications.
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| 12. |
- Petersson, Erik, 1985-
(författare)
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Vadstena krigsmanshus : En studie av den svenska kronans inrättning för sårade och gamla soldater cirka 1640–1780
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Den här avhandlingen handlar det underhåll till sårade och gamla soldater som den svenskastatsmakten organiserade under tidigmodern tid. Undersökningen tar sin utgångspunkt i den tid närstatsmakten började organisera mer omfattande hjälp för soldater, vilket var slutet på Gustav Vasasoch under Erik XIV:s regeringstid i mitten av 1500-talet. Motiven till att statsmakten organiseradehjälp för en del soldater var att dessa skulle ha offrat sin hälsa och arbetsförmåga i kronans tjänst, menså länge statsmakten fortsatte att vara relativt löst organiserad var även hjälpen till soldaterna avganska liten omfattning. Det ändrades under Gustav II Adolfs regering då planerna på att skapa ettkrigsmanshus i Vadstena etablerades, vilka senare genomfördes efter hans död och institutionen kundeta emot de första soldaterna senast 1640. I krigsmanshuset fick ett trettiotal soldater med familjeruppehälle, samtidigt som soldater boende i andra delar av landet fick stöd från krigsmanshuskassansom också administrerades från Vadstena. Mot slutet av 1600-talet blev kassan proportionellt merbetydelsefull än krigsmanshuset och runt år 1700 försörjde kassan flera tusen soldater runtom i riket.1700-talet innebar stora förändringar, bland annat genom att krigen blev färre, att krigaryrket intelängre var lika attraktivt som karriärväg för adelsmän och att statsmakten utvecklade andra mer civiladelar. Behovet av ett krigsmanshus fanns till sist inte längre och institutionen i Vadstena stängde förboende våren 1784, men kassan fanns kvar in på 1970-talet.
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| 13. |
- Rezk, Kamal, 1983-
(författare)
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Methods for Reducing the Complexity of Geometrical Structures Based on CFD Programming : Time Efficient Simulations Based on Volume Forces Coupled with Single and Two-phase Flow
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Throughout recent years, computer based programs have been applied to solve and analyse industrial problems encountered global fields such as automobile design for reduction of CO2-gas, designing wind parks aimed at increasing power output etc. One of these developed programs is Computational Fluid Dynamics (CFD) which numerically solves complex flow behaviour based on computer power.As there is an ongoing expansion of CFD usage in industry, certain issues need to be addressed as they are becoming more frequently encountered. The general demand for the simulation of larger control volumes and more advanced flow processes result in an extensive requirement of computer resources. Moreover, the implementation of commercial CFD codes in small-scaled industrial companies seems to generally be utilised as a black box based on the knowledge of fluid mechanic theory. Increased partnerships between industry and the academic world involving various CFD based design processes generally yield to a verbal communication interface, which is a crucial step in the process given the level of dependency between both sides.Based on these notions, a method for establishing time efficient CFD-models with implementation of volume forces as sink terms in the momentum equation is presented. The internal structure, or parts of the structure, in the simulation domain is removed which reduces the geometrical complexity and along with it, computational demand. These models are the basis of assessing the benefits of utilizing a numerical based design process in industry in which the CFD code is used as a communication tool for knowledge sharing with counterparts in different fields.
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| 14. |
- Strandberg, Gustav, 1977-
(författare)
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High-resolution simulations of two cold palaeo climates in Europe : MIS 3 and LGM
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The study of past climate is important because it increases our understanding of how the climate system works. Past climate is often reconstructed by using proxies (that is observations of things that tell something about past climate, for example tree rings, pollen in lake sediments and fossils). Model simulations of past climate further increases the knowledge since it has the possibility to gap the space and time between the sparse and scattered proxy observations, since a model simulation gives relatively continuous information about the whole simulated area. Model simulations can also give internally coherent information about parameters that is not easily reconstructed from proxies (for example heat fluxes). In this thesis two periods in the past are simulated by climate models: the Marine Isotope Stage 3 (MIS 3), 44 000 years ago, and the Last Glacial Maximum (LGM), 21 000 years ago. Both periods are characterised by low temperature, low sea level and low level of carbon dioxide. The topography in northern Europe is dominated by ice sheets covering Iceland, Norway and parts of Sweden at MIS3; and more extensive ice sheets covering Iceland, Scandinavia, the British Isles and Northern Germany at LGM. These periods are firstly simulated by a global climate model. Those simulations are subsequently used in a regional climate model to increase the level of detail over Europe. To make the regional climate model simulation more realistic vegetation simulated by a dynamical vegetation model is used in the regional climate model. The climate models simulate European climates much colder than today, especially at LGM. The temperature differences ranges from 5 to 45 °C colder than today; the largest differences being at the ice sheets where the perennial ice cover and the high altitude keep temperatures low. Precipitation is reduced with as much as almost 100 % in northern Europe due to reduced evaporation. Precipitation is increased with as much as 100 % in parts of southern Europe due to changes in atmospheric circulation. The simulations are in broad agreement with proxies, although there are differences. The vegetation model simulates tundra like vegetation (herbs and shrubs) in the ice-free parts of central and southern Europe. The eastern parts of Europe are dominated by needle-leaved trees. The short and cool summers limit vegetation. The simulated vegetation is in broad agreement with reconstructions. Sensitivity studies of vegetation show that changed vegetation can change the monthly mean temperature with 1-3 °C in some seasons and regions. The response depends on regional surface characteristics. Sensitivity studies of ice sheets show that the simulated climate is consistent with the assumptions about the ice sheet extent made in the simulation. The simulated climate is cold enough in northern Europe to support the ice sheet, and warm enough in southern Europe to prevent the ice sheet from expanding in this direction. A removal of the ice sheet would only have an effect on the local scale in the vicinity of the ice sheet, but this experiment did not include changes in the large-scale global atmospheric circulation. Although the regional climate model simulations are to a large degree depending on the global climate model simulations they provide new information. When comparing proxies with model data or studying local/regional climatic features (such as the interplay between climate and vegetation) high horizontal resolution, as in the regional climate model, is important.
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| 15. |
- Strandberg, Gustav, 1977-
(författare)
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Modelling regional climate-vegetation interactions in Europe : A palaeo perspective
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Studies in paleoclimate are important because they give us knowledge about how the climate system works and puts the current climate change in necessary perspective. By studying (pre)historic periods we increase our knowledge not just about these periods, but also about the processes that are important for climatic variations and changes. This thesis deals mainly with the interaction between climate and vegetation. Vegetation changes can affect climate in many different ways. These effects can be divided into two main categories: biogeochemical and biogeophysical processes. This thesis studies the biogeophysical effects of vegetation changes on climate in climate models. Climate models are a necessary tool for investigating how climate responds to changes in the climate system, as well as for making predictions of future climate. The biogeophysical processes are strongly related to characteristics of the land surface. Vegetation changes alter the land surface’s albedo (ability to reflect incoming solar radiation), roughness and evapotranspiration (the sum of evaporation and tran-spiration), which in turn affects the energy fluxes between the land surface and the atmosphere and thereby the climate. It is not, however, evident in what way; denser vegetation (e.g. forest instead of grassland) gives decreased albedo, which results in higher temperature, but also increased evapotranspiration, which contrastingly results in lower temperature. Vegetation changes are in this thesis studied in four different (pre)historic periods: two very cold periods with no human influence (c. 44,000 and 21,000 years ago), one warm period with minor human influence (c. 6,000 years ago) and a cold period with substantial human influence (c. 200 years ago). In addition to that the present climate is studied. The combination of these periods gives an estimate of the effect of both natural and anthropogenic vegetation on climate in different climatic contexts. The results show that vegetation changes can change temperature with 1–3 °C depending on season and region. The response is not the same everywhere, but depends on local properties of the land surface. During the winter half of the year, the albedo effect is usually most important as the difference in albedo between forest and open land is very large. During the summer half of the year the evapotranspiration effect is usually most important as differences in albedo between different vegetation types are smaller. A prerequisite for differences in evapotranspiration is that there is sufficient amount of water available. In dry regions, evapotranspiration does not change much with changes in vegetation, which means that the albedo effect will dominate also in summer. The conclusion of these studies is that vegetation changes can have a considerable effect on climate, comparable to the effect of increasing amounts of greenhouse gases in scenarios of future climate. Thus, it is important to have an appropriate description of the vegetation in studies of past, present and future climate. This means that vegetation has the potential to work as a feedback mechanism to natural climatic variations, but also that man can alter climate by altering the vegetation. It also means that mankind may have influenced climate before we started to use fossil fuel. Consequently, vegetation changes can be used as a means to mitigate climate change locally.
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| 16. |
- Thiagarajan, Kannan, 1981-
(författare)
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Tight-binding calculations of electron scattering rates in semiconducting zigzag carbon nanotubes
- 2011
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The technological interest in a material depends very much on its electrical, magnetic, optical and/or mechanical properties. In carbon nanotubes the atoms form a cylindrical structure with a diameter of the order 1 nm, but the nanotubes can be up to several hundred micrometers in length. This makes carbon nanotubes a remarkable model for one-dimensional systems. A lot of efforts have been dedicated to manufacturing carbon nanotubes, which is expected to be the material for the next generation of devices. Despite all the attention that carbon nanotubes have received from the scientific community, only rather limited progress has been made in the theoretical understanding of their physical properties. In this work, we attempt to provide an understanding of the electron-phonon and electron-defect interactions in semiconducting zigzag carbon nanotubes using a tight-binding approach. The electronic energy dispersion relations are calculated by applying the zone-folding technique to the dispersion relations of graphene. A fourth-nearest-neighbour force constant model has been applied to study the vibrational modes in the carbon nanotubes. Both the electron-phonon interaction and the electron-defect interaction are formulated within the tight-binding approximation, and analyzed in terms of their quantum mechanical scattering rates. Apart from the scattering rates, their components in terms of phonon absorption, phonon emission, backscattering and forward scattering have been determined and analyzed. The scattering rates for (5,0), (7,0), (10,0), (13,0) and (25,0) carbon nanotubes at room temperature and at 10K are presented and discussed. The phonon scattering rate is dependent on the lattice temperature in the interval 0-0.17 eV. We find that backscattering and phonon emission are dominant over forward scattering and phonon absorption in most of the energy interval. However, forward scattering and phonon absorption can be comparable to backscattering and phonon emission in limited energy intervals. The phonon modes associated with each peak in the electron-phonon scattering rates have been identified, and the similarities in the phonon scattering rates between different nanotubes are discussed. The dependence of the defect scattering rate on the tube diameter is similar to that of the phonon scattering rate. Both the phonon and the defect scattering rates show strong dependence on the tube diameter (i.e., the scattering rate decreases as a function of the index of the nanotube). It is observed that the backscattering and forward scattering for electrons interacting with defects occur with same frequency at all energies, in sharp contrast to the situation for phonon scattering. It is demonstrated that the differences in the scattering rate between different tubes are mainly due to the differences in their band structures.
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| 17. |
- Unander, Tomas
(författare)
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Characterization of Low Cost Printed Sensors for Smart Packaging
- 2008
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Currently there are very significant interests in printed electronics in the world. The possibility to produce electronics in a roll to roll printing process will considerably reduce the cost of the electronic devices. However, these new devices will most probably not replace the traditional silicon based electronics, but will be a complement in low cost applications such as in intelligent packages and other printable media. One interesting area is printable low cost sensors that add value to packages. In this thesis a study of the performance of low cost sensors is presented. The sensors were fabricated using commercial printing processes used in the graphical printing business. The sensors were characterized and evaluated for the intended application. The evaluated sensors were moisture sensing sensor solutions and touch sensitive sensor solutions. A printable touch sensitive sensor solution is presented where the sensor is incorporated into a high quality image such as in point of sales displays. The sensor solution showed good touch sensitivity at a variety of humidity levels. Four printed moisture sensor concepts are presented and characterized. Firstly, a moisture sensor that shows good correlation to the moisture content of cellulose based substrates. Secondly, a sensor that measures the relative humidity in the air, the sensor has a measuring accuracy of 0.22% at high relative humidity levels. Thirdly, a moisture sensor that utilizes unsintered silver nano-particles to measure the relative humidity in the air, the sensor has a linear response at very low relative humidity levels. And fourth, an action activated energy cell that provides power when activated by moisture. A concept of remote moisture sensing that utilizes ordinary low cost RFID tags has also been presented and characterized. The remote sensor solution works both with passive and semi-passive RFID systems. The study shows that it is possible to manufacture low cost sensors in commercial printing processes.
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| 18. |
- Unander, Tomas
(författare)
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System integration of electronic functionality in packaging application
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Sensor applications are becoming increasingly important as products are now being requested to be more and more intelligent and safe. As the costs involved in sensor technology decrease its usage will spread to new market segments including new areas with products that have never previously used such functionalities, including, wood fibre based products for packaging, hygiene or graphical use. Currently there is a significant interest in developing technology that will allow packages to become interactive and be integrated with digital services accessible on the Internet. In this thesis, the system integration of a hybrid RFID based sensor platform is presented. This proposed platform provides a trade-off between the communication performance and its compatibility with international standards and also includes flexibility in on‐package customization, including the type and number of sensors. In addition it combines the use of traditional silicon based electronics with printed electronics directly onto wood fibre based materials so as to enable the possibility of creating smart packages. Together with the system integration of the sensor platform, five printed moisture sensor concepts that are designed to work with the sensor platform are presented and characterized. Firstly, there is a moisture sensor that shows a good correlation to the moisture content of wood fibre based substrates. The second one involves a sensor that detects high relative humidity levels in the air and the third is an action activated energy cell that provides power when activated by moisture. The fourth one deals with two types of moisture sensors that utilize silver nano-particles in order to measure the relative humidity in the air. The final one is a printable touch sensitive sensor that is sensitive to the moisture contained in the hand. A concept of remote moisture sensing that utilizes ordinary low cost RFID tags has also been presented and characterized.The main focus is thus on system integration to, by combining silicon based electronics with printed electronics, find the most low cost solution with regards to flexibility, sensor functions and still meet the communication standards.
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| 19. |
- Öhlund, Thomas
(författare)
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Metal Films for Printed Electronics : Ink-substrate Interactions and Sintering
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A new manufacturing paradigm may lower the cost and environmental impact of existing products, as well as enable completely new products. Large scale, roll-to-roll manufacturing of flexible electronics and other functionality has great potential. However, a commercial breakthrough depends on a lower consumption of materials and energy compared with competing alternatives, and that sufficiently high performance and reliability of the products can be maintained. The substrate constitutes a large part of the product, and therefore its cost and environmental sustainability are important. Electrically conducting thin films are required in many functional devices and applications. In demanding applications, metal films offer the highest conductivity. In this thesis, paper substrates of various type and construction were characterized, and the characteristics were related to the performance of inkjet-printed metal patterns. Fast absorption of the ink carrier was beneficial for well-defined pattern geometry, as well as high conductivity. Surface roughness with topography variations of sufficiently large amplitude and frequency, was detrimental to the pattern definition and conductivity. Porosity was another important factor, where the characteristic pore size was much more important than the total pore volume. Apparent surface energy was important for non-absorbing substrates, but of limited importance for coatings with a high absorption rate. Applying thin polymer–based coatings on flexible non-porous films to provide a mechanism for ink solvent removal, improved the pattern definition significantly. Inkjet-printing of a ZnO-dispersion on uncoated paper provided a thin spot-coating, allowing conductivity of silver nanoparticle films. Conductive nanoparticle films could not form directly on the uncoated paper. The resulting performance of printed metal patterns was highly dependent on a well adapted sintering methodology. Several sintering methods were examined in this thesis, including conventional oven sintering, electrical sintering, microwave sintering, chemical sintering and intense pulsed light sintering. Specially designed coated papers with modified chemical and physical properties, were utilized for chemical low-temperature sintering of silver nanoparticle inks. For intense pulsed light sintering and material conversion of patterns, custom equipment was designed and built. Using the equipment, inkjet-printed copper oxide patterns were processed into highly conducting copper patterns. Custom-designed papers with mesoporous coatings and porous precoatings improved the reliablility and performance of the reduction and sintering process. The thesis aims to clarify how ink-substrate interactions and sintering methodology affect the performance and reliability of inkjet-printed nanoparticle patterns on flexible substrates. This improves the selection, adaptation, design and manufacturing of suitable substrates for inkjet-printed high conductivity patterns, such as circuit boards or RFID antennas.
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| 20. |
- Gustafsson, Stefan, et al.
(författare)
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Markers of imminent myocardial infarction
- 2024
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Ingår i: Nature Cardiovascular Research. - : Springer Nature. - 2731-0590.
-
Tidskriftsartikel (refereegranskat)abstract
- Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction within 6 months after the baseline blood draw. We analyzed 817 proteins and 1,025 metabolites in biobanked blood and 16 clinical variables. Forty-eight proteins, 43 metabolites, age, sex and systolic blood pressure were associated with the risk of an imminent first myocardial infarction. Brain natriuretic peptide was most consistently associated with the risk of imminent myocardial infarction. Using clinically readily available variables, we devised a prediction model for an imminent first myocardial infarction for clinical use in the general population, with good discriminatory performance and potential for motivating primary prevention efforts.
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| 21. |
- Hammarling, Krister, 1968-
(författare)
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Hydrogel-based pH-sensors : Development and characterisation of optical and electrical pH sensors based on stimuli-responsive hydrogels
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The ability to measure the chemical parameter pH is of high importance in many areas. With new government regulations and evolving markets, there is a strong motivation for improving such measurements and conducting research on new types of pH sensors and sensor materials. Stimuli-responsive hydrogels (a group of polymers) have attracted a lot of attention in recent decades, due to their ability to be customized to suit many applications. One specific area where they have attracted attention is pH sensor technology.Two stimuli-responsive hydrogels are used in this thesis. One is a non-toxic hydrogel, 1,4-acryl-terminated oligo(beta-amino esters) (1,4-AOBAE). Although it was previously used in drug- and DNA- delivery systems, it has not (to my knowledge) been used in a sensor configuration, and thus it is interesting to study. The second hydrogel, 1,3-acryl-terminated oligo(beta-amino esters) (1,3-AOBAE), is an improved variant of the first one. This improved hydrogel was synthesized because the original hydrogel crystallizes at room temperature, which meant that it was not optimal for various coating techniques. This hydrogel was characterized and verified for pH responsivity in two sensor configurations: electrical and optical. Designing a hydrogel for a specific application can be a complex procedure due to the many synthesizing parameters. For example, increasing a hydrogel's mechanical strength by introducing a higher degree of cross linking, leads to a smaller mesh size, which in turn leads to a lower diffusion rate and less solution absorption. The two hydrogels examined in this thesis respond to pH changes by absorbing or desorbing water; this change in the hydrogel's water content also changes its effective refractive index and permittivity. These changes can be measured using optical or electrical sensor systems. Three types of sensor systems were used in this thesis to verify the hydrogel's pH response and to ensure that they are suitable for use in thin-film techniques on various substrates (e.g. glass and plastic). The experimental results prove that these hydrogels are suitable for use in both electrical and optical sensor configurations. For electrical systems, a pH range of approximately 3-12 was achieved, and for optical, the range was approximately 2-12. These ranges can likely be improved, as the sensor film delaminated from the substrate at low pHs due to adhesion problems and as measurements above 12 were not conducted.The findings of this thesis could, after more research, have strong implications for the development of improved pH-sensor configurations, especially for medical and healthcare applications and in environmental monitoring.
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| 22. |
- Hertz, Erik, 1956-
(författare)
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Methodologies for Approximation of Unary Functions and Their Implementation in Hardware
- 2016
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Applications in computer graphics, digital signal processing, communication systems, robotics, astrophysics, fluid physics and many other areas have evolved to become very computation intensive. Algorithms are becoming increasingly complex and require higher accuracy in the computations. In addition, software solutions for these applications are in many cases not sufficient in terms of performance. A hardware implementation is therefore needed. A recurring bottleneck in the algorithms is the performance of the approximations of unary functions, such as trigonometric functions, logarithms and the square root, as well as binary functions such as division. The challenge is therefore to develop a methodology for the implementation of approximations of unary functions in hardware that can cope with the growing requirements. The methodology is required to result in fast execution time, low complexity basic operations that are simple to implement in hardware, and – sincemany applications are battery powered – low power consumption. To ensure appropriate performance of the entire computation in which the approximation is a part, the characteristics and distribution of the approximation error are also things that must be possible to manage. The new approximation methodologies presented in this thesis are of the type that aims to reduce the sizes of the look-up tables by the use of auxiliary functions. They are founded on a synthesis of parabolic functions by multiplication – instead of addition, which is the most common. Three approximation methodologies have been developed; the two last being further developments of the first. For some functions, such as roots, inverse and inverse roots, a straightforward solution with an approximation is not manageable. Since these functions are frequent in many computation intensive algorithms, it is necessary to find very efficient implementations of these functions. New methods for this are also presented in this thesis. They are all founded on working in a floating-point format, and, for the roots functions, a change of number base is also used. The transformations not only enable simpler solutions but also increased accuracy, since the approximation algorithm is performed on a mantissa of limited range. Tools for error analysis have been developed as well. The characteristics and distribution of the approximation error in the new methodologies are presented and compared with existing state-of-the-art methods such as CORDIC. The verification and evaluation of the solutions have to a large extent been made as comparative ASIC implementations with other approximation methods, separately or embedded in algorithms. As an example, an implementation of the logarithm made using the third methodology developed, Harmonized Parabolic Synthesis (HPS), is compared with an implementation using the CORDIC algorithm. Both implementations are designed to provide 15-bit resolution. The design implemented using HPS performs 12 times better than the CORDIC implementation in terms of throughput. In terms of energy consumption, the new methodology consumes 96% less. The chip area is 60% smaller than for the CORDIC algorithm. In summary, the new approximation methodologies presented are found to well meet the demanding requirements that exist in this area.
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| 23. |
- Hidman, Erik
(författare)
-
Attractiveness in Urban Design : A study of the production of attractive places
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This research project investigates the production of attractive places, through theory form and everyday life. The research study was originally sprung from practical questions regarding the extensive use of the term attractiveness in urban planning and design. What is the term intended to address? How is the term understood in local contexts? How is the term transformed to built environments? The term is rarely scrutinized and criticized and the understanding of the term, its meaning and implications is diverse. Starting from critical urban theory, the research project critically scrutinizes the term and contrasts it with local citizens perspectives of attractive towns. The research project proceeds from the idea of that places are produced not only by planning and urban design professionals, but also by people living in and visiting a place (Lefebvre, 1991). The research question addressed is How is the term attractiveness in built environments understood and designed in the perspectives of architects/urban designers and local citizens, and how can the term be explained to inform future planning of attractive urban environments?The research design consists of four sub-studies to investigate planning and local perspectives of attractiveness, its presentations and urban forms. The research design was set up in Kiruna and Gällivare, two mining towns in the sparsely populated Swedish north. These towns are undertaking major urban transformations due to the mining activities. Both municipalities explain the transformation processes as opportunities to become more attractive for people to settle as permanent residents. The term was investigated through discourse and qualitative content analysis, whilst the local citizen perspective was investigated through urban living labs.The conclusion was that the urban planning and design sphere of place production defines the term attractiveness according to their challenges. The term addresses the contemporary situation of place competition where places compete about labour, companies and capital on a global market (Harvey, 1989; Brenner et al. 2014). A discourse of attractiveness can be formulated to focus on three interest areas: urban economics, social wellbeing, and urban townscapes. The term can further be explained as an approach of reinventing places as attractive through urbanization and agglomeration.The local citizens idea of attractiveness is produced through societal challenges, local opportunities as well as practical experiences. The production of attractiveness is affected partly by everyday experiences and partly by assimilated knowledge about the place and society, from among others media reporting and official urban planning documents. As produced through knowledge, pedagogical processes also affect the idea of attractiveness. Physically, the attractive town is described as a place someone has cared of designing, including a legible town plan, locally distinct character, clear borders between built up areas and nature, and coherent connections between neighbourhoods.Some reflections drawn from the studies. In order to create truly attractive places, the term attractiveness should be inclusive to perspectives of local citizens. There are, among others, an ethical concern and a potential in this statement. The ethical consideration is that the term attractiveness has different meanings by different communities and individuals; the use of the term is persuasive with the potential to hide agendas seen as attractive according to only some viewpoints. On the other hand there is a potential in acknowledging attractiveness as being produced by everyone practicing place; it opens possibilities for a more diverse and inclusive term with richer ideas of attractive places.
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| 24. |
- Jung, Bärbel, 1961-
(författare)
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On effectiveness in colorectal surgery : mechanical bowel preparation or not in elective colonic surgery and treatment options for elderly patients with rectal cancer
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The management of patients undergoing colorectal surgery has changed in recent decades. Efforts have been made to show that perioperative physiological stress to the patient can be minimised with standardised care programmes and thus improve short term outcome after colorectal surgery. Mechanical bowel preparation (MBP), for instance, has been questioned as part of standard management. There are studies highlighting the effect of cancer treatment and its side effects in the elderly, showing that geriatric patients benefit from oncological therapy in much the same way as younger patients. The impact of this information on surgical and oncological practice in Sweden today is not known. To assess the effectiveness of colorectal surgery we need both randomised controlled trials and population-based cohort studies. We have performed a trial on colonic surgery with and without preoperative mechanical bowel preparation, as well as a nation-wide register study comparing treatment and outcome of rectal cancer in two age groups. In a randomised controlled trial 1505 patients from 21 hospitals were randomised to MBP or no-MBP prior to open elective colonic resection. There were no differences in overall complication rates between the groups: cardiovascular 5.1% with MBP vs. 4.6% without MBP; general infection 7.9% vs. 6.8%; and surgical site complications 15.1% vs. 16.1%. The proportion of patients reaching at least one primary endpoint was 24.5% vs. 23.7% respectively. The patients experience of and postoperative recovery after MBP or no-MBP was evaluated in 105 of the patients in the bowel preparation trial at three of the participating hospitals. Sixty-five patients received MBP and 40 patients did not. In the MBP group 52% needed assistance with bowel preparation. Day 4 postoperatively patients in the no-MBP group perceived more discomfort than patients in the MBP group, p<0.05. Bowel emptying occurred significantly earlier in the no-MBP group than in the MBP group, p<0.05.In an experimental study the effect of MBP on intramucosal bacterial count was evaluated. Macroscopically normal colon mucosa was collected from 37 patients (20 MBP and 17 No-MBP) undergoing elective colorectal surgery at three hospitals. MBP did not influence the median colony count of E. coli, Bacteroides, or total median colony count, information that was previously unknown. These three studies imply that MBP can be omitted before elective colonic resection. In a population-based register study, treatment for rectal cancer in patients ≥ 75 years and those < 75 years was evaluated using data from the Swedish Rectal Cancer Register 1995-2004 (N=15104). This study revealed that preoperative radiotherapy was used less in patients > 75 years. There was also a higher threshold for surgery in this group, and they more often received a permanent stoma compared to younger patients. Outcome in terms of 5-year local recurrence rate and 5-year cancer-specific survival differed very little between the older and younger patient groups who underwent abdominal tumour resection with curative intent. We suggest future studies focusing on ways of reducing surgical and perioperative stress and on quality of life when assessing suitable treatment modalities for rectal cancer.
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| 25. |
- Lindberg, Malin, Professor, 1978-, et al.
(författare)
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Co-Creative Place Innovation in an Arctic Town
- 2020
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Ingår i: Journal of Place Management and Development. - : Emerald Group Publishing Limited. - 1753-8335 .- 1753-8343. ; 13:4, s. 447-463
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – The purpose of the study is to shed light on co-creative approaches for place innovation in an Arctic town, based on the relocation of Kiruna’s city center in northern Sweden. Three cases of co-creative innovation processes in Kiruna are investigated and compared: an R&D project about local perceptions and visions of attractive urban environments, an R&D project about norm-creative design principles for inclusive and attractive urban design, and an R&D project about cross-industrial synergies for city center attractiveness.Design/methodology/approach – The study’s research design encompasses a comparative and participatory approach. The comparative approach implies investigation and comparison of three cases of co-creative innovation processes in Kiruna. The participatory approach implies joint development of new knowledge by researchers and local actors. The data consists of participatory observations of workshops and qualitative interviews with local actors.Findings – The study reveals that the studied processes have harnessed the city center relocation as an opportunity to make Kiruna more attractive to residents and visitors, by employing the co-creative approaches of Living Lab, Now-Wow-How and Norm-creative design. These approaches have enabled experts and local actors to jointly identify excluding patterns and norms in the relocation process, and to envision inclusive and attractive (re-)configurations and (re-)conceptualizations of the future Kiruna.Research implications – The results add to the academic strand of inclusive urban transformation, by providing insights into co-creative approaches for re-imagining an Arctic town in times of industrial and social change. New insights are provided regarding how the geographical, industrial and cultural identity of an Arctic town can be harnessed to envision new configuration, content and communication that is attractive and accessible for a diversity of residents and visitors. Practical implications – The results highlight the potential to harness Arctic and rural characteristics in the promotion of urban attractiveness and public wellbeing, especially when combined with co-creative identification and transformation of excluding norms and patterns.Originality/value – The results provide new insights into how co-creative approaches may facilitate innovative and inclusive renewal of towns and cities in the Arctic and beyond.
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| 26. |
- Lindfeldt, Erik G., 1978-
(författare)
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A trinity of sense : Using biomass in the transport sector for climate change mitigation
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyses two strategies for decreasing anthropogenic carbon dioxide (CO2) emissions: to capture and store CO2, and to increase the use of biomass. First, two concepts for CO2 capture with low capture penalties are evaluated. The concepts are an integrated gasification combined cycle where the oxygen is supplied by a membrane reactor, and a hybrid cycle where the CO2 is captured at elevated pressure. Although the cycles have comparatively high efficiencies and low penalties, they illustrate the inevitable fact that capturing CO2 will always induce significant efficiency penalties. Other strategies are also needed if CO2 emissions are to be forcefully decreased. An alternative is increased use of biomass, which partially could be used for production of motor fuels (biofuels). This work examines arguments for directing biomass to the transport sector, analyses how biofuels (and also some other means) may be used to reduce CO2 emissions and increase security of motor fuel supply. The thesis also explores the possibility of reducing CO2 emissions by comparatively easy and cost-efficient CO2 capture from concentrated CO2 streams available in some types of biofuel plants. Many conclusions of the thesis could be associated with either of three meanings of the word sense: First, there is reason in biofuel production – since it e.g. reduces oil dependence. From a climate change mitigation perspective, however, motor fuel production is often a CO2-inefficient use of biomass, but the thesis explores how biofuels’ climate change mitigation effects may be increased by introducing low-cost CO2 capture. Second, the Swedish promotion of biofuels appears to have been governed more by a feeling for attaining other goals than striving for curbing climate change. Third, it seems to have been the prevalent opinion among politicians that the advantages of biofuels – among them their climate change mitigation benefits – are far greater than the disadvantages and that they should be promoted. Another conclusion of the thesis is that biofuels alone are not enough to drastically decrease transport CO2 emissions; a variety of measures are needed such as fuels from renewable electricity and improvements of vehicle fuel economy.
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| 27. |
- Nilsson, Anna, 1974-
(författare)
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Identification and Syntheses of Semiochemicals Affecting Mnesampela privata and Trioza apicalis
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Autumn gum moth, Mnesampela privata (Lepidoptera: Geometridae) is an endemic Australian moth whose larvae feed upon species of Eucalyptus. The moths favorite host plants are E. globulus and E. nitens which are the most important species used in commercial plantations of the Australian pulpwood industry. The autumn gum moth has become one of the most significant outbreak insects of eucalyptus plantations throughout Australia. As a consequence great financial losses to the forest industry occur. Today insecticides such as pyrethroids are used for control of eucalyptus defoliators as M. privata. The carrot psyllid, Trioza apicalis (Homoptera: Psylloidea), is one of the major pests of carrot (Daucus carota) in northern Europe. The psyllid causes curling of the carrot leafs and reduction of plant growth. Today the carrot crops are protected with the pyrethroid insecticide cypermethrin, which is toxic to aquatic organisms and is, from 2010, prohibited for use in Sweden by the Swedish Chemicals Inspectorate. An alternative to insecticides is to protect the seedlings with semiochemicals, a chemical substance or mixture of them that carries a message. This thesis describes the identification and the syntheses of semiochemicals from the above mentioned insect species. From analysis of abdominal tip extracts of M. privata females from Tasmania a blend of (3Z,6Z,9Z)-3,6,9-nonadecatriene and (3Z,6Z,9Z)-3,6,9-heneicosatriene was identified as the sex pheromone of this species. The identification of the C19- and C21-trienes was confirmed by synthesis. In the analysis of carrot leaf extracts we found a compound, α-cis-bergamotene, that induces antennal response in the carrot psyllid. This is just the beginning of the studies of trying to manipulate this psyllid with semiochemicals instead of insecticides.
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| 28. |
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| 29. |
- Nilsson, Maria
(författare)
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Differences and similarities in work absence behavior : - empirical evidence from micro data
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis consists of three self-contained essays about absenteeism. Essay I analyzes if the design of the insurance system affects work absence, i.e. the classic insurance problem of moral hazard. Several reforms of the sickness insurance system were implemented during the period 1991-1996. Using Negative binomial models with fixed effects, the analysis show that both workers and employers changed their behavior due to the reforms. We also find that the extent of moral hazard varies depending on work contract structures. The reforms reducing the compensation levels decreased workers’ absence, both the number of absent days and the number of absence spells. The reform in 1992, introducing sick pay paid by the employers, also decreased absence levels, which probably can be explained by changes in personnel policy such as increased use of monitoring and screening of workers. Essay II examines the background to gender differences in work absence. Women are found, as in many earlier studies, to have higher absence levels than men. Our analysis, using finite mixture models, reveals that there are a group of women, comprised of about 41% of the women in our sample, that have a high average demand of absence. Among men, the high demand group is smaller consisting of about 36% of the male sample. The absence behavior differs as much between groups within gender as it does between men and women. The access to panel data covering the period 1971-1991 enables an analysis of the increased gender gap over time. Our analysis shows that the increased gender gap can be attributed to changes in behavior rather than in observable characteristics. Essay III analyzes the difference in work absence between natives and immigrants. Immigrants are found to have higher absence than natives when measured as the number of absent days. For the number of absence spells, the pattern for immigrants and natives is about the same. The analysis, using panel data and count data models, show that natives and immigrants have different characteristics concerning family situation, work conditions and health. We also find that natives and immigrants respond differently to these characteristics. We find, for example, that the absence of natives and immigrants are differently related to both economic incentives and work environment. Finally, our analysis shows that differences in work conditions and work environment only can explain a minor part of the ethnic differences in absence during the 1980’s.
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| 30. |
- Nilsson, Per-Erik, 1981-
(författare)
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“Everybody Welcome to France” : Secularism, Governmentality & Fantasy in the French Republic 2003-2011
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- What does it mean to be “secular”? How are “secular” identities constructed and negotiated? How can one understand that “secularism” has become an important marker of identity for nationalistic forces in Europe?In the dissertation “Everybody, Welcome to France” the author sets out to inquire into the topic of secularism and national identity in contemporary France. The specific research question is how France has been articulated as a “secular” republic in political speech and legislative text in 2003-2011 and how this articulation relates to conceptions of “nation”, “integration”, and “citizenship”. The author analyzes the articulation of France as a secular republic in two case studies. The first one is the Islamic Veil Affair in 2003-4 when the French Republic legislated against the wearing of conspicuous religious symbols in public schools, and the second is when the wearing of burkas and niqabs were prohibited in public space in 2010 (law implemented in 2011). The author argues that these affairs became sceneries for a nationalistic reification by the political elite through the construction of an imagined intrusive other whose presence was thought to be in need of neutralization or deportation. The author subsequently suggests that the political elite’s conceptions of secularism during the analyzed period can be understood in light of an illiberal turn in European politics where categories like “secularism”, “tolerance”, and “freedom” have become emblems in a self-righteous construction of a unified and enlightened national “we” as opposed to an uncivilized and unworthy “them”.The analysis is carried out with discourse analytical methodology and rests on critical religion/secularism theory.
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| 31. |
- Nilsson, Staffan, 1974-
(författare)
-
From Higher Education To Professional Practice : A comparative study of physicians' and engineers' learning and competence use
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus of this thesis is on describing and analysing recently graduated physicians’ and engineers’ experiences of the relationship between the professional education programs and the respective professional practices. The aim is to explore the professionals’ reasons for their educational and career choices, what they learn in professional education, the demands they encounter in the workplace, and the perceived needs and opportunities for learning and further development in their professional practices.This study is based on a comparative design and the empirical data have been collected in interviews with physicians and master’s level engineers in information technology.The theoretical framework is structured around three parts, consisting of theories of professionalisation, theories concerned with the functions of higher education, and theories concerned with the concepts of knowledge, competence and qualifications. There is a close relationship between the process of professionalisation, the authority of the professions, the legitimacy of professional knowledge, and the higher education institutions.The results indicate that theory and practice are intimately integrated in the physicians’ professional education, whereas the engineers’ experiences of the educational program are characterised by little overlap between theory and practice. Furthermore, the physicians emphasise the importance of theoretical specialist knowledge and socio-communicative competence while the engineers instead stress the importance of generalist competence. The educational knowledge base is relatively static for both physicians and engineers. However, whereas there is a correspondence between the educational and the professional knowledge base in the case of the physicians they are only a loosely coupled in the case of the engineers. This can be attributed to the changing nature of the engineers’ professional knowledge base, which is characterised by constant change. The physicians regard their professional education as a rational preparation for the world of work. Although education does provide a general foundation for further professional development and learning, the engineers associate their professional education more with a symbolic ritual. For physicians, the formal credentials are a legal requirement to practise the profession. Education is regarded as constituting an important credential also for the engineers as it increases individual employability. The physicians tend to emphasise the use value of the educational program, while the engineers instead stress the exchange value of their educational program.
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| 32. |
- Nilsson, Viktor, 1985-
(författare)
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Highly Concentrated Electrolytes for Lithium Batteries : From fundamentals to cell tests
- 2018
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The electrolyte is a crucial part of any lithium battery, strongly affecting longevity and safety. It has to survive rather severe conditions, not the least at the electrode/electrolyte interfaces. Current commercial electrolytes based on 1 M LiPF 6 in a mixture of organic solvents balance the requirements on conductivity and electrochemical stability, but they are volatile and degrade when operated at temperatures above ca. 70°C. The salt could potentially be replaced with e.g. LiTFSI, but corrosion of the aluminium current collector is an issue. Replacing the graphite negative electrode by Li metal for large gains in energy density challenges the electrolyte further by exposing it to freshly deposited Li, leading to poor coulombic efficiency (CE) and consumption of both Li and electrolyte. Highly concentrated electrolytes (up to > 4 M) have emerged as a possible remedy, by a changed solvation structure such that all solvent molecules are coordinated to cations – leading to a lowered volatility and melting point, an increased charge carrier density and electrochemical stability, but a higher viscosity and a lower ionic conductivity.Here two approaches to highly concentrated electrolytes are evaluated. First, LiTFSI and acetonitrile electrolytes with respect to increased electrochemical stability and in particular the passivating solid electrolyte interphase (SEI) on the anode is studied using electrochemical techniques and X-ray photoelectron spectroscopy. Second, lowering the liquidus temperature by high salt concentration is utilized to create an electrolyte solely of LiTFSI and ethylene carbonate, tested for application in Li metal batteries by characterizing the morphology of plated Li using scanning electron microscopy and the CE by galvanostatic polarization. While the first approach shows dramatic improvements, the inherent weaknesses cannot be completely avoided, the second approach provides some promising cycling results for Li metal based cells. This points towards further investigations of the SEI, and possibly long-term safe cycling of Li metal anodes.
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| 33. |
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| 34. |
- Pape Møller, Anders, et al.
(författare)
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Interaction of climate change with effects of conspecific and heterospecific density on reproduction
- 2020
-
Ingår i: Oikos. - : Wiley. - 0030-1299 .- 1600-0706. ; 129:12, s. 1807-1819
-
Tidskriftsartikel (refereegranskat)abstract
- We studied the relationship between temperature and the coexistence of great tit Parus major and blue tit Cyanistes caeruleus, breeding in 75 study plots across Europe and North Africa. We expected an advance in laying date and a reduction in clutch size during warmer springs as a general response to climate warming and a delay in laying date and a reduction in clutch size during warmer winters due to density‐dependent effects. As expected, as spring temperature increases laying date advances and as winter temperature increases clutch size is reduced in both species. Density of great tit affected the relationship between winter temperature and laying date in great and blue tit. Specifically, as density of great tit increased and temperature in winter increased both species started to reproduce later. Density of blue tit affected the relationship between spring temperature and blue and great tit laying date. Thus, both species start to reproduce earlier with increasing spring temperature as density of blue tit increases, which was not an expected outcome, since we expected that increasing spring temperature should advance laying date, while increasing density should delay it cancelling each other out. Climate warming and its interaction with density affects clutch size of great tits but not of blue tits. As predicted, great tit clutch size is reduced more with density of blue tits as temperature in winter increases. The relationship between spring temperature and density on clutch size of great tits depends on whether the increase is in density of great tit or blue tit. Therefore, an increase in temperature negatively affected the coexistence of blue and great tits differently in both species. Thus, blue tit clutch size was unaffected by the interaction effect of density with temperature, while great tit clutch size was affected in multiple ways by these interactions terms.
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| 35. |
- Perjons, Erik, 1959-
(författare)
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Model-Driven Process Design : Aligning Value Networks, Enterprise Goals, Services and IT Systems
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of business-IT alignment is to optimise the relation between business and IT in order to maximise the business value of IT. Successful business-IT alignment can be enabled by business processes and e-processes functioning as adaptive mediators between business and IT systems. Business processes are the ways actors work in enterprises and collaborate in value networks, while e-processes support a flexible flow of information between IT systems and business processes. The overall goal of this thesis is to propose methods for business process and e-process design and evaluation for achieving alignment between enterprise goals and IT systems. The methods are based on model-driven approaches, using enterprise and software models. More precisely, the proposed methods can be used for designing models of business processes supporting the fulfilment of enterprise goals in the setting of a value network; for designing models of generic and reusable business processes that support the fulfilment of enterprise goals; for designing models of e-processes that support a flexible alignment of IT systems with business processes; and for evaluating the extent to which business processes are aligned with enterprise goals and IT systems. The result of the thesis can be used to support business and system designers with practical knowledge on how to align business and IT systems in order to create efficient, high-quality, flexible and innovative organisations. The research presented in this thesis has been carried out following the design science paradigm. This paradigm is characterised by the creation of new and innovative artefacts for solving general problems, and the evaluation of their benefits and drawbacks.
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| 36. |
- Sandzén, Birger, 1944-
(författare)
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Complicated gallstone disease in Sweden 1988-2006 : a register study
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background The gallstone prevalence in the western world is 10-20%. Most gallstones are silent, but symptoms and complications appear in 20-40%. The incidence of symptom development in patients with silent gallstones is 2-4% per year. The indication for surgical (including endoscopic) treatment of gallstones is symptoms of certain magnitude, and no contraindications. During the past three decades an intense technical development in imaging (ultrasound, computerised tomography and magnetic resonance imaging), endoscopic therapy, and surgery has taken place. The aim of this thesis is to scrutinize changes in management of complicated gallstone disease on a population-based level, using national register data. Have the new methods improved the treatment of acute pancreatitis, common bile duct stones and acute gallbladder disease?Methods Data is collected from National Patient Register (NPR) run by The Swedish National Board of Health and Welfare. NPR collects discharge data from every admission from every Swedish hospital. Mortality is calculated as standardised mortality ratio (SMR) using age-, gender-, and calendar year specific survival estimates. We have studied both general trends in admissions and treatment alternatives and outcomes in defined patient cohorts. Length of hospital stay, readmission, and mortality has been used as proxy indicators of the effectiveness of treatment strategies used.Results During the study period mortality in acute pancreatitis (SMR within 90 days of admission) improved and hospital stay for all patients with acute pancreatitis decreased. Cholecystectomy rate at or shortly after index stay for mild acute biliary pancreatitis increased from 14.5 % to 22.7 %. Of all patients with acute pancreatitis 68.4 % of the patients had no aetiological diagnosis in the register. The incidence of bile duct interventions increased 27.8% from 1988 through 2006. The favoured treatment of bile duct stones changed from open choledocholithectomy to endoscopic sphincterotomy with stone extraction during the same period. However, in 2006, still 19.6% of bile duct interventions for stones were performed as choledochotomy and in the great majority of these cases as open surgery. This indicates a continuing need of education in open bile duct surgery. Mean hospital stay for treatment of common bile duct stones decreased significantly (4.5 days) during the period studied. The mortality (SMR) diminished although without statistical significance during the time period, and there was no significant difference in SMR between choledochotomy and endoscopic sphincterotomy. For acute gallbladder disease a moderate increase of admissions occurred from 1988 through 2006. The relation between acute cholecystectomies versus all cholecystectomies did not change during this period. Of all patients admitted with acute gallbladder disease 32.3 % were cholecystectomised during their first hospital stay, whereas 20.3 % underwent elective cholecystectomy and 6.1 % emergency cholecystectomy within two years of first admission. 41.4 % of patients were not operated on for gallbladder disease within two years of first admission with this diagnosis. Mortality from first admission and 90 days onwards was elevated three-fold during the entire period without time trend, without statistical difference between age groups, and between patients who had cholecystectomy at first admission or later.Conclusion During the audit period treatment of acute pancreatitis improved. However, etiological classification and timing of cholecystectomy in mild acute biliary pancreatitis fell below accepted guidelines. Interventions on the common bile duct for gallstone disease increased significantly. Common bile duct clearance has been separated from cholecystectomy, and cholecystectomy often not done. Only one third of all patients with acute gallbladder disease underwent cholecystectomy at first admission. There is room for improvement in treatment of complicatedgallstone disease, and, gallstone surgeons still need good knowledge in open biliary surgery.
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| 37. |
- Sidén, Johan
(författare)
-
On the Design, Characterization and Optimization of RFID Tag Antennas
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Remotely read electronic identification tags are establishing as the standard method of identifying objects in transport logistcs. They are referred to as RFID tags and with successful research and development they are likely to one day replace all of todays barcodes, found on a wide variety of items and objects. As RFID systems consist of many different parts spanning over just as many academic subjects, this thesis investigates some of the main issues regarding RFID tag antennas. Large focus is put on performance and cost optimization of relatively simple one‐layer antennas, suitable for mass production in commercial printing presses using electrically conductive ink. Examples of specially designed antennas include ones that can operate upon metallic objects and antennas that can be physicall bent. It is also shown how RFID tag antennas that will be widely exposed to the human eye can include a commercial value by letting heir geometric design originate from group insignias and company logos. The thesis also presents a solution of how pairs of ordinary low cost RFID tags can be used as remotely read moisture sensors.
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| 38. |
- Wölbing, Dirk, 1985-
(författare)
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The PANDA electromagnetic calorimeter at photon energies below 100 MeV
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The PANDA experiment (antiproton annihilation at Darmstadt) is designed for studies of the strong force in the transition region between perturbative and non-perturbative quantum chromo dynamics (QCD). It will be built and placed at the high-energy storage ring, HESR, at FAIR (Facility for antiproton and ion research) in Darmstadt and start its first experiments in 2025. In the HESR antiprotons with a momentum in the range 1.5 GeV/c to 15 GeV/c will collide with a fixed hydrogen or nuclear target. The PANDA detector is designed for e.g. detailed spectroscopy of hadrons produced in antiproton-proton interactions. In 2026 PANDA will be upgraded with the implementation and completion of some subdetectors, e.g. the EDD (end disc detector of internal reflected Cherenkov light) for charged particle velocity measurements in the forward direction.This thesis summarizes preparatory experiments with a PANDA forward endcap electromagnetic calorimeter (EMC) prototype, performed at the tagged photon facility at the MAX IV laboratory in Lund to study the response to photons with energies below 100 MeV using vacuum photo tetrodes (VPTTs) as photo sensors. The results show that with VPTT photo sensors, in combination with sampling ADCs, the technical design report (TDR) requirement, with regard to energy resolution, can be fulfilled even for energies below 100 MeV. It is also shown that the energy resolution is not significantly influenced by the insertion of the EDD in front of the forward endcap EMC.
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| 39. |
- Zartova, Irina, 1976-
(författare)
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Mesonic fusion - pion and eta meson production in light ion nuclear fusion reactions
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis describes two experiments performed in the storage ring CELSIUS at The Svedberg Laboratory in Uppsala. In the first experiment the importance of three - nucleon clustering in the six - nucelon system was investigated. The total cross section for the production of the ground state and the 3.56 MeV second excited state of 6Li in the 3He(3He,6Li)π+ reaction has been measured at two beam energies, 261.1 and 262.5 MeV, corresponding to center - of - mass energies 1.2 and 1.9 MeV above the production threshold for the 3.56 MeV state. For the ground state the result was 347 ± 84 ± 42 and 92 ± 84 ± 11 nb respectively. The result for the 3.56 MeV state, 104 ± 23 ± 12 and 56 ± 35 ± 7 nb respectively, is compared to the result of a previous study where the 3.56 MeV state was populated in the d(4He,6Li)π0 reaction. In the second experiment a clean sample of 5×105 eta mesons was prepared by means of the d(p,3He)η reaction. Eta production was tagged by the precise determination of the kinetic energy of the associated 3He ions. In the subsequent decay of eta mesons, channels with lepton - anti - lepton pairs were studied in the WASA detector. In a separate study properties of the WASA deuterium pellet target were investigated and in particular the effects on the beam of the beam - target interactions. In both sets of experiments the fused nuclear system was detected by means of a zero - degree spectrometer with a semiconductor detector telescope. Choosing the detectors to match the rather different requirements, precise information regarding the identity and the momentum of the detected ions could be obtained in both cases.
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| 40. |
- Åhlin, Erik, 1980-
(författare)
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Functional Role of Immune Complexes in Rheumatic and Parasitic Diseases
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Immune complexes (IC) have key pathological roles in both autoimmune and infectious diseases. In this thesis functional mechanisms behind IC-driven inflammation in rheumatic diseases and tropical infections have been studied, with special focus on the contribution of autoantibodies and cytokine-inducing properties of IC. In the autoimmune disease SLE, increased levels of IC-induced cytokines were associated with both increased classical complement activation and the occurrence of the autoantibodies anti-SSA and anti-SSB, both directed against RNA-associated antigens. In addition, complement activation and anti-SSA synergistically predisposed to higher levels of IC in sera. In the following study it was demonstrated that also other autoantibodies against RNA-associated autoantigens were more enriched than anti-dsDNA in SLE IC. Sudanese Visceral Leishmaniasis (VL) patients had elevated IC levels, and precipitated IC induced higher levels of GM-CSF, IL10, IL6 and IL1RA than control IC. Levels of IC were especially prominent in severely ill patients receiving antimony treatment, and a parallel association with IC induction of GM-CSF was demonstrated. Leishmania-infected patients were often rheumatoid factor (RF) positive and a substantial number displayed reactivity towards cyclic citrullinated peptide (CCP) antigens. Contrary to what was seen in Sudanese RA sera, the CCP reactivity was not restricted to citrulline but reacted equally well with arginine-containing control peptides. Levels of anti-CCP among VL patients were not due to cross-reactions with, or CCP-reactivity bound to IC. I have demonstrated that IC are associated with the presence of autoantibodies in both SLE and in Leishmania infection. In SLE, autoantibodies against RNA-associated antigens were more prone to form circulating IC than anti-dsDNA. In Leishmania infection false reactivity against the CCP-autoantigen correlated to IC levels although the IC themselves did not contain such reactivity. In both diseases higher IC levels were associated with a more active disease, and purified IC induced key cytokines in disease pathogeneses.
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| 41. |
- Öhlund, Thomas, 1973-
(författare)
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Coated Surfaces for Inkjet-Printed Conductors
- 2012
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, a number of commercially available paper substrates of various types are characterized and their characteristics related to the performance of inkjet-printed conductors using silver nanoparticle ink. The evaluated performance variables are electrical conductivity as well as the minimum achievable conductor width and the edge raggedness. It is shown that quick absorption of the ink carrier is beneficial for achieving well defined conductor geometry and high conductivity. Surface roughness with topography variations of sufficiently large amplitude and frequency is detrimental to print definition and conductivity. Porosity is another important factor, where the characteristic pore size is much more important than the total pore volume. A nearly ideal porous coating has large total pore volume but small characteristic pore size, preferably smaller than individual nanoparticles in the ink. Apparent surface energy is important for non-absorbing substrates but of limited importance for coatings with a high absorption rate.Additionally, a concept for improving the geometric definition of inkjet-printed conductors on nonporous films has been demonstrated. By coating the films with polymer–based coatings to provide a means of ink solvent removal, minimum conductor width were reduced a factor 2 or more.Intimately connected to the end performance of printed conductors is a well adapted sintering methodology. A comparative evaluation of a number of selective sintering methods has been performed on paper substrates with different heat tolerance. Pulsed high-power white light was found to be a good compromise between conductivity performance, reliability and production adaptability.The purpose of the work conducted in this thesis is to increase the knowledge base in how surface characteristics of papers and flexible films affect performance of printed nanoparticle structures. This would improve selection, adaption of, or manufacturing of such substrates to suit printed high conductivity patterns such as printed antennas for packaging.
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| 42. |
- Andersson, Erik, 1979-, et al.
(författare)
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Kollegialt Lärande i Örebros Skolor – KLÖS-projektet : Hur kan lärares kollegiala lärprocesser stödjas i syfte att skapa hållbara strukturer för utvecklingsarbete?
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet KLÖS har undersökt hur lärares kollegiala lärprocesser kan stödjas i syfte att skapa hållbara strukturer för utvecklingsarbete. Målet var att skapa en Örebromodell för kollegialt lärande. En avslutande reflektion kring resultatet är att etableringen av denna modell kräver ett omfattande engagemang och tar tid att få på plats. Det är vår uppfattning att ett flertal aspekter återstår att undersöka. Bland annat är det intressant att undersöka hur arbetet med det kollegiala lärandet fortskrider på pilotskolan. Frågor som är intressanta är: Vilka faktorer har betydelse för att arbetet med kollegialt lärande ska bli permanent och fungera som ett naturligt sätt att arbeta med utveckling av praktiken? Vad blir resultatet av de utvecklingsomgångar som genomförts? Hur följs detta resultat upp och leder det till bestående gynnsamma förändringar? Frågorna handlar om hållbarhet och därmed om hur projektet går från att vara ett projekt som avslutas och glöms bort till att bli ett levande verktyg för utvecklingsarbete som kan göra en verklig skillnad i och för praktiken över tid. Eftersom mycket tid och resurser används till utvecklingsarbete i skolan är det viktigt att det arbete som görs verkligen leder till en konkret och för verksamheten gynnsam förändring. Det innebär att frågan om utvecklings- arbetets hållbarhet är en av de viktigaste frågorna. Det verktyg som utvecklats i projektet och som kommit att symbolisera det kollegiala arbetet på pilotskolan är KLÖS-hjulet. Frågan om hur KLÖS-hjulet 2.0 kan utvecklas och anpassas så att det verkligen blir ett flexibelt och användbart verktyg för att stötta det kollegiala lärandet är kanske den alla viktigaste konkreta frågan. Frågor som är besläktade med frågan om hållbarhet är de som syftar till att undersöka hur det kollegiala lärandet kan bli mer robust. Till dessa hör frågor om hur lärledarens roll kan förstärkas, hur verktyg som stöttar lärares observation och analys av den egna verksamheten kan designas, hur ansvar och engagemang på alla nivåer kan förstärkas och bli synligt samt hur arbetet med kollegialt lärande kan utvärderas. Vi har under projektets gång sett hur lärare behöver stöd i arbetet med att systematiskt identifiera behov i verksamheten för att sedan utforska möjligheter att utveckla och förändra praktiken. Medverkan från forskare som ställt frågor, problematiserat och belyst olika perspektiv har i flera fall varit avgörande för hur ett utvecklingsbehov har identifierats, avgränsats och formulerats som en undersökningsbar fråga. Det är av avgörande betydelse att utvecklingsarbetet inte står och faller med denna medverkan. Verksamheten måste själv ta fram strukturer för hur lärare och lärledare får ett tillfredsställande stöd i sitt utvecklingsarbete så att de har möjlighet att göra kollegialt lärande till en naturlig del av sitt arbete där de känner sig så bekanta med KLÖS-hjulet att de själva kan ställa de frågor som krävs. Således behöver många funktioner, både centralt och lokalt samverka för att vidareutveckla och stötta kollegialt lärande för att utveckla undervisningen i Örebro skolor.
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| 43. |
- Andersson, Gunnel, 1958-
(författare)
-
Urinary incontinence : prevalence, treatment seeking behaviour, experiences, and perceptions among persons with and without urinary leakage
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis is to describe urinary incontinence (UI) from a population perspective and to describe experiences and perceptions of UI from an individual perspective. This includes assessing the prevalence of urinary incontinence as well as describing treatment seeking and experiences of living with UI. A secondary aim was to describe the perception of UI among cultures other than the Swedish mainstream, exemplified in this case by Syrian women living in Sweden. Both quantitative and qualitative methods were used, including questionnaires and interviews. Studies I and II were quantitative studies based on a population-based study. Together with a postal survey on general health and living conditions “Life & Health”, a questionnaire on urinary incontinence was sent out to 15 360 randomly-selected residents aged 18-79 in Orebro County, Sweden. In Study I, UI was found to affect 19%. The majority of the respondents experienced minor problems, and only 18% of those reporting UI wanted treatment. However, there was also a group who reported severe problems, but despite this 42% of them did not want treatment. Study II investigated why people with UI refrain from seeking care and treatment. It was found that the desire for treatment was regulated by the frequency of UI, being restricted from participating in various activities, the degree of inconvenience, and the type of UI. Studies III and IV were both qualitative interview studies, describing older women’s experiences of living with UI (Study III) and Syrian women’s perceptions of UI (Study IV). There were similarities between the results of these two studies; the women described UI as a normal and expected problem, and they knew that the district nurse could prescribe incontinence protections and that treatments existed. In both studies, the women expressed difficulties in making contact with the health care service, while the women who did not speak Swedish (Study IV) also had difficulties due to different communication problems. In conclusion, it is important that health care resources are optimized to identify and meet the needs of those who experience major problems with UI, and that there is awareness of the communication difficulties that can be present in meeting with people who speak other languages. However it is also important not to medicalize those who experience minor problems and who have the desire to manage on their own.
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| 44. |
- Andersson, Henrik, 1975-
(författare)
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Position Sensitive Detectors : Device Technology and Applications in Spectroscopy
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with the development, processing and characterization of position sensitive detectors and, in addition, to the development of compact and cost effective spectrometers. Position sensitive detectors are used to measure, with great accuracy and speed, the position of a light spot incident on the surface. Their main use is for triangulation, displacement and vibration measurements. A type of position sensitive detector based on the MOS principle and using optically transparent indium tin oxide as a gate contact has been developed. This type of detector utilizes the MOS principle where an induced channel forms beneath the gate oxide in the surface of the Silicon substrate. One and two dimensional detectors have both been fabricated and characterized. The first measurements showed that the linearity did not fulfil expectations and it was suspected that stress induced by the gate contact could be the reason for the seemingly high nonlinearity. Further investigations into both the p-n junction and the MOS type position sensitive detectors lead to the conclusion that the indium tin oxide gate is responsible for inducing a substantial stress in the surface of the detector, thus giving rise to increased position nonlinearity. The heat treatment step which was conducted was determined to be critical as either a too short or too long heat treatment resulted in stress in the gate and channel leading to position nonlinearity. If a correctly timed heat treatment is performed then the detector’s linearity is in parity with the best commercial position sensitive detectors. In addition, the development of very small, compact and cost effective spectrometers has been performed with the aim of constructing devices for use in the process industry. The development of a wedge shaped array of Fabry-Perot interferometers that can be mounted directly on top of a detector makes it possible to construct a very compact spectrometer using the minimum amount of optics. This wedge interferometer has been evaluated by means of array pixel detectors and position sensitive detectors for both the infrared and the visible wavelength ranges. When used with a position sensitive detector it is necessary to use a slit to record the intensity of the interferogram for many points over the detector, equivalent to pixels on an array detector. Usually the use of moving parts in a spectrometer will impose the use of high precision scanning mechanisms and calibration. By using a position sensitive detector for the interferogram readout both the position and the intensity are known for every measurement point and thus the demands placed on the scanning system are minimized.
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| 45. |
- Beijer, Kristina, et al.
(författare)
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Physical activity may compensate for prolonged TV time regarding pulse rate-a cross-sectional study
- 2018
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 123:4, s. 247-254
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Tidskriftsartikel (refereegranskat)abstract
- Background: Regular exercise reduces pulse rate, but it is less clear how prolonged sitting time affects pulse rate. Our hypothesis was that high physical activity could compensate for prolonged sitting time regarding the pulse rate.Methods: Regression analysis was performed on cross-sectional data including 47,457 men and women based on two Swedish cohort studies, EpiHealth (18–45 years) and LifeGene (45–75 years). Self-reported leisure time physical activity was given in five levels, from low (level 1) to vigorous (level 5), and television time was used as a proxy of sitting time.Results: A higher physical activity (level 4 compared to level 1) was associated with a lower pulse rate in middle-aged females (-2.7 beats per minute [bpm]; 95% CI -3.3 to -2.2) and males (-4.0 bpm; 95% CI -4.7 to -3.4). The relationship between physical activity and pulse rate was strongest in the young. A prolonged television time (3 h compared to 1 h per day) was associated with a slightly higher pulse rate in middle-aged females (+0.6 bpm; 95% CI +0.3 to +0.8) and males (+0.9 bpm; 95% CI +0.7 to +1.2). Among participants with a prolonged television time (3 h), those with a high physical activity (level 4) had a lower pulse rate compared to those with a low physical activity (level 1).Conclusions: A prolonged television time was associated with a high pulse rate, while high physical activity was associated with a low pulse rate. The results suggest that a high physical activity could compensate for a prolonged television time regarding pulse rate.
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| 46. |
- Deusebio, Enrico, 1985-
(författare)
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Numerical Investigation of Rotating and Stratified Turbulence
- 2012
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Atmospheric and oceanic flows are strongly affected by rotation and stratification. Rotation is exerted through Coriolis forces which mainly act in horizontal planes whereas stratification largely affects the motion along the vertical direction through buoyancy forces, the latters related to the vertical variation of the fluid density. Aiming at a better understanding of atmospheric and oceanic processes, in this thesis the properties of turbulence in rotating and stably stratified flows are studied by means of numerical simulations, with and without the presence of solid walls. A new code is developed in order to carry out high-resolution numerical simulations of geostrophic turbulence forced at large scales. The code was heavily parallelized with MPI (Message Passing Interface) in order to be run on massively parallel computers. The main problem which has been investigated is how the turbulent cascade is affected by the presence of strong but finite rotation and stratification. As opposed to the early theories in the field of geostrophic turbulence, we show that there is a forward energy cascade which is initiated at large scales. The contribution of this process to the general dynamic is secondary at large scales but becomes dominant at smaller scales where leads to a shallowing of the energy spectrum. Despite the idealized set-up of the simulations, two-point statistics show remarkable agreement with measurements in the atmosphere, suggesting that this process may be an important mechanism for energy transfer in the atmosphere. The effect of stratification in wall-bounded turbulence is investigated by means of direct numerical simulations of open-channel flows. An existing full-channel code was modified in order to optimize the grid in the vertical direction and avoid the clustering of grid points at the upper boundary, where the solid wall is replaced by a free-shear condition. The stable stratification which results from a cooling applied at the solid wall largely affects the outer structures of the boundary layer, whereas the near-wall structures appear to be mostly unchanged. The effect of gravity waves is also studied, and a new decomposition is introduced in order to separate the gravity wave field from the turbulent field.
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| 47. |
- Eklund, Michael, 1988-, et al.
(författare)
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Effect of spironolactone on vascular stiffness in hemodialysis patients : a randomized crossover trial
- 2022
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Ingår i: Upsala Journal of Medical Sciences. - : Upsala Medical Society. - 0300-9734 .- 2000-1967. ; 127:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The role of spironolactone treatment in hemodialysis patients is debated, but a survival benefit is suggested. Mineralocorticoids and chronic kidney disease have been linked to cardiovascular fibrosis. Therefore, we hypothesized that spironolactone would affect vascular stiffness, cardiac systolic, and diastolic function in hemodialysis patients.Methods: This was a randomized crossover study in hemodialysis patients supplemented with an echocardiographic case series. All outcomes reported here were secondary in the trial and were assessed without blinding. Block randomization and allocation determined treatment order. Participants received 50 mg spironolactone daily for 12 weeks and untreated observation for another 12 weeks. Pulse wave velocity (PWV) was measured before and after treatment and observation. Doppler-echocardiography was conducted before and after treatment. Systemic arterial compliance indexed to body surface area (SACi), left ventricular ejection fraction (LVEF), the peak early diastolic mitral inflow velocity (E), the peak late diastolic mitral inflow velocity (A), and the peak early diastolic myocardial lengthening velocity (E') were measured. E/A and E/E' were then calculated. Statistical analyses were conducted per protocol. A generalized linear mixed model with random participant effects was used for PWV. The Wilcoxon signed-rank test was used for echocardiographic variables.Results: Thirty participants were recruited, 18 completed follow-up, and 17 were included in PWV-analyses. Spironolactone treatment showed a tendency toward an increase in PWV of 1.34 (95% confidence interval: -0.11 to 2.78) m/s, which was not statistically significant (P = 0.07). There were no significant changes in any of the other variables (LVEF, E/A, E/E', or SACi).Conclusions: We found no evidence supporting an effect of 12-week administration of spironolactone 50 mg daily on vascular stiffness, cardiac systolic, or diastolic function in hemodialysis patients.
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| 48. |
- Eklund, Michael, 1988-, et al.
(författare)
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Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients : a randomised crossover trial
- 2021
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Läkareförening, Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 126:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Spironolactone treatment reduces mortality in haemodialysis (HD) patients. The objective of this study was to evaluate if spironolactone affects cardiac electric activity in this population.Methods: Participants were randomised to start with spironolactone 50 mg daily or observation (12 weeks) with subsequent washout (6 weeks) and crossover to the other intervention (12 weeks). Long-term electrocardiograms were recorded and assessed with blinding to treatment. The primary outcome was premature ventricular complexes (PVC), and secondary outcomes were atrial premature contractions (APC) and heart rate variability (HRV).Results: . HRV time-domain variables increased during treatment, the standard deviation of all beat-to-beat intervals by 18 (95% CI: 3.3 to 32) milliseconds (ms) and the standard deviation of the averages of beat-to-beat intervals in all 5-min segments of the entire recording by 16 (95% CI: 1.5 to 30) ms. There were no significant differences in other variables.Conclusion: Spironolactone treatment increases PVCs in HD, indicating a possible proarrhythmic effect. However, improved cardiac autonomic function, as indicated by an increased HRV, may contribute to the survival benefit from spironolactone treatment in HD patients.
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| 49. |
- Eklöf, Anders, 1956-
(författare)
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Project work, independence and critical thinking
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis studies how students do projects in a Swedish upper secondaryschool. The students have to produce products and at the same time provethem self as independent in relation to the teachers, and negotiate therequirements of the project setting and the written instructions within thegroup. The study focuses on what comes out as problematic for the students,how they solve these dilemma situations and what resources are used in orderto do so.A choice was made only to analyse student group interaction in parts ofthe project process where the teachers were not physically present thus fillinga research gap.The empirical material was collected during three years in sex secondaryschool classes through filmed sessions of groups or pairs working with theirproject.Each of the four articles primarily focuses a special dilemma; structure,independence, instructions and critical thinking. By combining Goffman’sframe analysis with the concepts of risk and uncertainty from a Risk – societyperspective, issues related to what it means to do project work asindependent, critical 21st-century learner are illustrated and discussed.The choice to look only at situations in which students have to managewithout the aid of a physically present teacher illuminates several practicalconsequences like an unwillingness to go to the teacher and ask questions andan increased concentration on and interpretation of the written instructions. Adevelopment of Miller and Parlett’s (1974) discussion of student approach tocues are suggested. The concept of the cue choosing student are constructedin order to better respond to demands from an individualised interactionsociety. The study also emphasises how the students have to balance differentframeworks in order to be both authors and assessed students. Byimplementing a risk society perspective new ways of analysing andunderstanding independence and classroom interaction is suggested and arecontextualization of critical thinking proposed.
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| 50. |
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