| 1. |
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| 2. |
- Andersson, Greger, et al.
(författare)
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Stad och landsbygd
- 1994
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Ingår i: Musiken i Sverige.1. - 9170547009 - 9185428825 ; , s. 359-395
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
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| 4. |
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| 5. |
- Andersson, Greger, et al.
(författare)
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Musicerandet
- 2002
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Ingår i: Slotten & landskapet. - 915183927X ; , s. 145-150
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Bokkapitel (populärvet., debatt m.m.)
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| 6. |
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| 7. |
- Bondesson, Lennart, 1944-, et al.
(författare)
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Probability calculus for silent elimination : A method for medium access control
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A probability problem arising in the context of medium access control in wireless networks is considered. It is described as a problem with n urns, each one having one ball at time 0. Each ball leaves its urn after a geometrically distributed time. Then there is a first time T such that no departures take place at the times T +1, T +2, . . . , T +k, where k is fixed. The focus is on the probability distribution of (XT , ST , T), where XT is the number of balls that leave their urns at time T and ST is the number of balls remaining there at that time. Efficient recursion formulas are derived. Asymptotics and continuous time approximations are considered. For k = ∞, T is the maximum of n geometrically distributed variables. This case has earlier got a large literature.
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| 8. |
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| 9. |
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| 10. |
- Fernberg, Patrik, et al.
(författare)
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Piezoresistive performance of long-fiber composites with carbon nanotube doped matrix
- 2009
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Ingår i: Journal of Intelligent Materials Systems and Structures. - 1045-389X .- 1530-8138. ; 20:9, s. 1017-1023
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Tidskriftsartikel (refereegranskat)abstract
- The electrical and mechanical properties of carbon nanotube (CNT) doped epoxy resin and composites based on this matrix were studied. The investigation was carried out on neat nanocomposites and on structural composites i.e., when the nanocomposite is used as matrix in composite materials reinforced with long continuous fibers. Tensile tests showed that CNT doped epoxy exhibited clear piezoresistive behavior. It was, however, also shown that geometrical changes of the specimen also contribute significantly to resistance changes during tensile loading. Particular effort was made to establish the relations between transverse cracking in glass fiber cross-ply laminates with nanotube doped matrix and changes of electrical resistance. It was shown that changes of electrical resistance during tensile loading of composites containing CNT doped matrix gives highly relevant information about the damage state of the material. In an unloaded state the resistance change is proportional to the relative change of stiffness. This work demonstrates that there are three different mechanisms, which contribute to changes of electrical resistance of a composite specimen subjected to tensile strain. These three mechanisms are: (a) geometrical changes of the specimen (b) piezoresistive material response, and (c) accumulation of micro-damage.
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| 11. |
- Fernberg, Patrik, et al.
(författare)
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Piezoresistive performance of long fibre composites with carbon nanotube doped matrix
- 2007
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Ingår i: Proceedings of COMP07.
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Konferensbidrag (refereegranskat)abstract
- The electrical and mechanical properties of carbon nanotube doped epoxy resin and composites based on this matrix were studied. The investigation was carried out on neat nanocomposites and on structural composites i.e. when the nanocomposite is used as matrix in composite materials reinforced with long continuous fibers. Tensile tests showed that carbon nanotube (CNT) doped epoxy exhibited a clear piezoresistive behavior. It was however also shown that geometrical changes of the specimen also contribute significantly to resistance changes during tensile loading. Particular effort was made to establish the relations between transverse cracking in glass fibre cross-ply laminates with nanotube doped matrix and resistance changes. It was shown that resistance changes during tensile loading of composites containing CNT doped matrix gives highly relevant information about the damage state of the material. In an unloaded state the resistance change is proportional to the relative change of stiffness. This work demonstrates that there are three different mechanisms which contribute to resistance changes of a composite specimen subjected to tensile strain. These three mechanisms are: a) geometrical changes of the specimen b) piezoresistive material response and c) accumulation of micro-damage
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| 12. |
- Fernberg, Patrik, et al.
(författare)
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Strain and damage sensing during loading of carbon nanotube doped composites
- 2009
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Ingår i: ICCM International Conferences on Composite Materials. - London : IOM Communications.
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Konferensbidrag (refereegranskat)abstract
- This work explores the possibility to use resistance changes in a carbon nanotube (CNT) doped composites to monitor deformations and damage. Most other studies in the field are done on simplified uniaxial loading whereas current work also evaluates the possibilities to monitor strain in more complex loading case, such as bending.
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| 13. |
- Joensuu, Heikki, et al.
(författare)
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Adjuvant Capecitabine, Docetaxel, Cyclophosphamide, and Epirubicin for Early Breast Cancer : Final Analysis of the Randomized FinXX Trial
- 2012
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:1, s. 11-18
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Capecitabine is an active agent in the treatment of breast cancer. It is not known whether integration of capecitabine into an adjuvant regimen that contains a taxane, an anthracycline, and cyclophosphamide improves outcome in early breast cancer.Patients and Methods: Women with axillary node-positive or high-risk node-negative breast cancer were randomly assigned to receive either three cycles of docetaxel and capecitabine (TX) followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (CEX; n = 753) or three cycles of docetaxel (T) followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF; n = 747). The primary end point was recurrence-free survival (RFS).Results: During a median follow-up time of 59 months, 214 RFS events occurred (local or distant recurrences or deaths; TX/CEX, n = 96; T/CEF, n = 118). RFS was not significantly different between the groups (hazard ratio [HR], 0.79; 95% CI, 0.60 to 1.04; P = .087; 5-year RFS, 86.6% for TX/CEX v 84.1% for T/CEF). Fifty-six patients assigned to TX/CEX died during the follow-up compared with 75 of patients assigned to T/CEF (HR, 0.73; 95% CI, 0.52 to 1.04; P = .080). In exploratory analyses, TX/CEX improved breast cancer-specific survival (HR, 0.64; 95% CI, 0.44 to 0.95; P = .027) and RFS in women with triple-negative disease and in women who had more than three metastatic axillary lymph nodes at the time of diagnosis. We detected little severe late toxicity. Conclusion: Integration of capecitabine into a regimen that contains docetaxel, epirubicin, and cyclophosphamide did not improve RFS significantly compared with a similar regimen without capecitabine. J Clin Oncol 30:11-18. (c) 2011 by American Society of Clinical Oncology
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| 14. |
- Joensuu, Heikki, et al.
(författare)
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Adjuvant Capecitabine for Early Breast Cancer : 15-Year Overall Survival Results From a Randomized Trial
- 2022
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 40:10, s. 1051-1058
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Few data are available regarding the influence of adjuvant capecitabine on long-term survival of patients with early breast cancer.METHODS: The Finland Capecitabine Trial (FinXX) is a randomized, open-label, multicenter trial that evaluates integration of capecitabine to an adjuvant chemotherapy regimen containing a taxane and an anthracycline for the treatment of early breast cancer. Between January 27, 2004, and May 29, 2007, 1,500 patients with axillary node-positive or high-risk node-negative early breast cancer were accrued. The patients were randomly allocated to either TX-CEX, consisting of three cycles of docetaxel (T) plus capecitabine (X) followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (CEX, 753 patients), or to T-CEF, consisting of three cycles of docetaxel followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF, 747 patients). We performed a protocol-scheduled analysis of overall survival on the basis of approximately 15-year follow-up of the patients.RESULTS: The data collection was locked on December 31, 2020. By this date, the median follow-up time of the patients alive was 15.3 years (interquartile range, 14.5-16.1 years) in the TX-CEX group and 15.4 years (interquartile range, 14.8-16.0 years) in the T-CEF group. Patients assigned to TX-CEX survived longer than those assigned to T-CEF (hazard ratio 0.81; 95% CI, 0.66 to 0.99; P = .037). The 15-year survival rate was 77.6% in the TX-CEX group and 73.3% in the T-CEF group. In exploratory subgroup analyses, patients with estrogen receptor-negative cancer and those with triple-negative cancer treated with TX-CEX tended to live longer than those treated with T-CEF.CONCLUSION: Addition of capecitabine to a chemotherapy regimen that contained docetaxel, epirubicin, and cyclophosphamide prolonged the survival of patients with early breast cancer.
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| 15. |
- Joensuu, Heikki, et al.
(författare)
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Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for breast cancer : an open-label, randomised controlled trial
- 2009
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 10:12, s. 1145-1151
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Tidskriftsartikel (refereegranskat)abstract
- Background Standard adjuvant chemotherapy regimens for patients with moderate-to-high-risk early breast cancer typically contain a taxane, an anthracycline, and cyclophosphamide. We aimed to investigate whether integration of capecitabine into such a regimen enhances outcome. Methods In this open-label trial, we randomly assigned (centrally by computer; stratified by node status, HER2 status, and centre) 1500 women with axillary node-positive or high-risk node-negative breast cancer to either three cycles of capecitabine and docetaxel followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (capecitabine group, n=753), or to three cycles of docetaxel followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (control group, n=747). The primary endpoint was recurrence-free survival. A planned interim analysis was done after 3 years' median follow-tip. Efficacy analyses were by modified intention to treat. The study is registered with ClinicalTrials.gov, number NCT00114816. Findings Two patients in each group were excluded from efficacy analyses because of wthdrawal of consent or distant metastases. After a median follow-up of 35 months (IQR 25.5-43-6), recurrence-free survival at 3 years was better with the capecitabine regimen than with control (93% vs 89%; hazard ratio 0.66, 95% CI 0.47-0-94; p=0.020). The capecitabine regimen was associated with more cases of grade 3 or 4 diarrhoea (46/740 [6%] vs 25/741 [3%]) and hand-foot syndrome (83/741 [11%] vs 2/741 [<1%]) and the control regimen with more occurrences of grade 3 or 4 neutropenia (368/375 198%] vs 325/378 186%]) and febrile neutropenia (65/741[9%] vs 33/742 [4%]). More patients discontinued planned treatment in the capecitabine group than in the control group (178/744 [24%] vs 23/741 [3%]). Four patients in the capecitabine group and two in the control group died from potentially treatment-related causes. Interpretation The capecitabine-containing chemotherapy regimen reduced breast cancer recurrence compared with a control schedule of standard agents. Capecitabine administration was frequently discontinued because of adverse effects. Funding Roche, Sanofi-Aventis, AstraZeneca, Cancer Society of Finland.
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| 16. |
- Joensuu, Heikki, et al.
(författare)
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Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer : The Randomized Clinical FinXX Trial
- 2017
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Ingår i: JAMA Oncology. - : American Medical Association (AMA). - 2374-2437 .- 2374-2445. ; 3:6, s. 793-800
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Capecitabine is not considered a standard agent in the adjuvant treatment of early breast cancer. The results of this study suggest that addition of adjuvant capecitabine to a regimen that contains docetaxel, epirubicin, and cyclophosphamide improves survival outcomes of patients with triple-negative breast cancer (TNBC).OBJECTIVE To investigate the effect of capecitabine on long-term survival outcomes of patients with early breast cancer, particularly in subgroups defined by cancer estrogen receptor (ER) and progesterone receptor (PR) content, and HER2 content (human epidermal growth factor receptor 2).DESIGN, SETTING, AND PARTICIPANTS This is an exploratory analysis of the multicenter FinXX randomized clinical trial that accrued 1500 women in Finland and Sweden between January 27, 2004, and May 29, 2007. About half received 3 cycles of docetaxel followed by 3 cycles of cyclophosphamide, epirubicin, and fluorouracil (T+CEF), while the other half received 3 cycles of docetaxel plus capecitabine followed by 3 cycles of cyclophosphamide, epirubicin, and capecitabine (TX+CEX). Data analysis took place between January 27, 2004, and December 31, 2015.MAIN OUTCOMES AND MEASURES Recurrence-free survival (RFS).RESULTS Following random allocation, 747 women received T+CEF, and 753 women received TX+CEX. Five patients were excluded from the intention-to-treat population (3 had overt distant metastases at the time of randomization; 2 withdrew consent). The median age of the remaining 1495 patients was 53 years at the time of study entry; 157 (11%) had axillary node-negative disease; 1142 (76%) had ER-positive cancer; and 282 (19%) had HER2-positive cancer. The median follow-up time after random allocation was 10.3 years. There was no significant difference in RFS or overall survival between the groups (hazard ratio [HR], 0.88; 95% CI, 0.71-1.08; P = .23; and HR, 0.84, 95% CI, 0.66-1.07; P = .15; respectively). Breast cancer-specific survival tended to favor the capecitabine group (HR, 0.79; 95% CI, 0.60-1.04; P = .10). When RFS and survival of the patients were compared within the subgroups defined by cancer steroid hormone receptor status (ER and/or PR positive vs ER and PR negative) and HER2 status (positive vs negative), TX+CEX was more effective than T+CEF in the subset of patients with TNBC (HR, 0.53; 95% CI, 0.31-0.92; P = .02; and HR, 0.55, 95% CI, 0.31-0.96; P = .03; respectively).CONCLUSIONS AND RELEVANCE Capecitabine administration with docetaxel, epirubicin, and cyclophosphamide did not prolong RFS or survival compared with a regimen that contained only standard agents. Patients with TNBC had favorable survival outcomes when treated with the capecitabine-containing regimen in an exploratory subgroup analysis.
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| 17. |
- Joensuu, Heikki, et al.
(författare)
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Outcome of patients with HER2-positive breast cancer treated with or without adjuvant trastuzumab in the Finland Capecitabine Trial (FinXX)
- 2014
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 53:2, s. 186-194
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundLittle information is available about survival outcomes of patients with HER2-positive early breast cancer treated with adjuvant capecitabine-containing chemotherapy with or without trastuzumab.Patients and methodsOne thousand and five hundred patients with early breast cancer were entered to the Finland Capecitabine trial (FinXX) between January 2004 and May 2007, and were randomly assigned to receive either three cycles of adjuvant TX (docetaxel, capecitabine) followed by three cycles of CEX (cyclophosphamide, epirubicin, capecitabine; TX-CEX) or three cycles of docetaxel followed by three cycles of CEF (cyclophosphamide, epirubicin, fluorouracil; T-CEF). The primary endpoint was recurrence-free survival (RFS). The study protocol was amended in May 2005 while study accrual was ongoing to allow adjuvant trastuzumab for patients with HER2-positive cancer. Of the 284 patients with HER2-positive cancer accrued to FinXX, 176 (62.0%) received trastuzumab after amending the study protocol, 131 for 12 months and 45 for nine weeks. The median follow-up time was 6.7 years.ResultsPatients with HER2-positive cancer who received trastuzumab had better RFS than those who did not (five-year RFS 89.2% vs. 75.9%; HR 0.41, 95% CI 0.23 -0.72; p = 0.001). Patients treated with trastuzumab for 12 months or nine weeks had similar RFS. There was no significant interaction between trastuzumab administration and the type of chemotherapy. Four (2.3%) patients treated with trastuzumab had heart failure or left ventricular dysfunction, three of these received capecitabine.ConclusionAdjuvant trastuzumab improves RFS of patients treated with TX-CEX or T-CEF. Few patients had cardiac failure.
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| 18. |
- Kaplan, Alexander, et al.
(författare)
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The impact of zinc-coating on laser hybrid welding of steel
- 2007
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Ingår i: Congress proceedings. - Orlando, Fla : Laser institute of America. - 9780912035888
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Konferensbidrag (refereegranskat)abstract
- Hybrid Nd:YAG/MAG welding of ultra high strength steel is studied for 1,5 mm thick sheets in I-, T- and overlap joint type configuration. Untreated and zinc-coated steels were compared, causing distinct differences in terms of process stability and welding result. For zinc coating it can be distinguished between domains of trapped zinc layers like in overlap and T-joints and free surface zinc coatings. While the former situation is critical for violent evaporation and in turn spatter in the absence of a gap, in the latter case a zinc domain outside the weld pool area evaporates due to its low boiling point, thus not disturbing the laser welding process. However, during hybrid welding arc instabilities and short circuiting were observed when changing to zinc coated steel, even for butt joints. One hypothesis is an impact of the zinc vapour atoms on the plasma, with an ionisation energy 20% higher than iron, but 40% lower than Ar. The influence was calculated by Saha's equation. The process window is much narrower than for uncoated steel. Moreover, an enhanced generation of spatter and fume can be observed. A theory for the impact of zinc-coating on hybrid welding is postulated.
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| 19. |
- Karakatsanis, Andreas, et al.
(författare)
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Meta-analysis of neoadjuvant therapy and its impact in facilitating breast conservation in operable breast cancer
- 2018
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 105:5, s. 469-481
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundNeoadjuvant therapy (NAT) for operable breast cancer may facilitate more breast-conserving surgery (BCS). It seems, however, that this benefit is not being realized fully.MethodsA systematic review of the literature was performed. RCTs were included. The criteria for inclusion were: documentation of surgical assessment before and after NAT, surgery performed (BCS or mastectomy), and clinical and pathological responses.ResultsA total of 1452 patients from seven RCTs met the inclusion criteria. After NAT, the feasibilityof BCS increased from 43⋅3to60⋅4 per cent (P < 0⋅001), but BCS was performed in only 51⋅8percent(P = 0⋅04). Only 31 per cent of patients who became eligible for BCS (assessed on clinical response)underwent BCS (pooled rate ratio 0⋅31, 95 per cent c.i. 0⋅22 to 0⋅44; P < 0⋅001). Of the mastectomycandidates who achieved a pathological complete response after NAT, only 41 per cent underwent BCS(pooled rate ratio 0⋅41, 0⋅23 to 0⋅74; P = 0⋅003). The main factors that influenced the decision not to shiftto BCS, even though it was feasible, were clinical assessment before NAT, multicentricity and tumoursize at presentation.ConclusionBreast surgery performed after NAT does not reflect tumour response, resulting in potentially unnecessary radical surgery, especially mastectomy. The barriers to maximizing the surgical benefits of NAT need to be better understood and explored. Still unnecessary mastectomies
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| 20. |
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| 21. |
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| 22. |
- Lönn, David, et al.
(författare)
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Experimental and finite element robustness studies of a bumper system subjected to an offset impact loading
- 2011
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Ingår i: International Journal of Crashworthiness. - Abingdon, Oxford, UK : Taylor & Francis Group. - 1358-8265 .- 1754-2111. ; 16:2, s. 155-168
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Tidskriftsartikel (refereegranskat)abstract
- A product of high quality is a product that performs well, not only in exactly the situations it was designed to handle but also in slightly different situations that arise in the usage of the product. As a specific example, the performance of a bumper system should not depend on small fluctuations in the manufacturing process or on small variations in the impact event. In this work, the robustness of an existing vehicle bumper system subjected to a crash load has been evaluated both experimentally and numerically. In the latter case, different widely used approaches to numerically assess the robustness have been utilised. A reliable numerical robustness study provides the designer with a valuable tool for improving a design, and an evaluation of these methods in this context is therefore of interest. It is concluded that for the example under study, both the Monte Carlo method and the metamodel-based Monte Carlo methods work well. Furthermore, for moderate dispersions levels, i.e. a small design space with no bifurcation in the deformation pattern, a linear response approximation is shown to have a sufficient accuracy to be used in the metamodel-based robustness analysis. The performed numerical robustness studies also point out that the performance of a nominal simulation, i.e. a simulation conducted with mean values for all variables, does not in general predict the mean performance of the finite element model. Finally, some possible design improvements for the bumper system under study are also identified
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| 23. |
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| 24. |
- Lönngren, Johanna, 1985-, et al.
(författare)
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Sustainable Development in Nano-Perspectives : An Innovative Student Initiative
- 2010
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Ingår i: Engineering Education in Sustainable Development, conference proceedings. - : Engineering Education in Sustainable Development, Gothenburg, Sweden.
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Konferensbidrag (refereegranskat)abstract
- This paper describes and discusses a novel class for sustainable development at the faculty of engineering at Lund University, Sweden. Based on personal experience and student questionnaires, the study discusses applied pedagogical approaches (case study, role play, matrix approach) and suggests improvements to the structure of the class. The project is a student initiative, making student involvement and its effects on learning for sustainable development central topics of this paper, thereby challenging the notion of engineering students as passive receivers of education for sustainable development.
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| 25. |
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| 26. |
- Malmodin, Jens, et al.
(författare)
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Life Cycle Assessment of ICT : Carbon Footprint and Operational Electricity Use from the Operator, National, and Subscriber Perspective in Sweden
- 2014
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Ingår i: Journal of Industrial Ecology. - : Wiley. - 1088-1980 .- 1530-9290. ; 18:6, s. 829-845
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Tidskriftsartikel (refereegranskat)abstract
- The use of information and communication technology (ICT) is growing throughout society, and new products and solutions are developed at an increasing rate. To enable environmental assessment of specific ICT products and other products that rely on ICT in some way, a more complete, detailed, and up-to-date study based on real measurements is needed. To date, similar studies have not been readily available or fully comprehensive. This study assessed the overall operational electricity use and life-cycle-based carbon footprint (CF) relating to ICT in Sweden, including activities not commonly addressed previously, such as shared data transport networks and data centers and manufacturing of network infrastructure. Specific, detailed inventory data are presented and used for assessment of the Internet Protocol core network, data transmission, operator activities, and access network. These specific data, in combination with secondary, more generic data for end-user equipment, allow a comprehensive overall assessment. The majority of the ICT network CF is the result of end-user equipment, mainly personal computers, followed by third-party enterprise networks and data centers and then access networks. The parts closest to the user proved to be clearly responsible for the majority of the impact. The results are presented for Swedish ICT networks and for ICT networks in general based on a global average electricity mix.
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Nilsson, Greger
(författare)
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Cardiovascular Side Effects of Radiotherapy in Breast Cancer
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the thesis was to study cardiovascular side effects of radiotherapy (RT) in breast cancer (BC).In a study base of 25,171 women with BC diagnosed 1970-2000, we found a statistically significant 12% increase of stroke, compared to the stroke incidence in the background population.A case-control study of 282 cases with BC followed by a stroke and 1:1 matched controls with BC but not stroke was performed. In women irradiated to internal mammary chain (IMC) and supraclavicular lymph nodes (SCL) vs. a pooled group of women not irradiated or irradiated to targets other than IMC and SCL, a statistically significant increase of stroke with an odds ratio of 1.8 was observed. There were no associations between BC laterality, targets of RT, and hemisphere location of stroke. The radiation targets IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose.A study of 199 patients with BC, examined by coronary angiography, detected a four- to seven-fold increase of high grade coronary artery stenosis in mid and distal left anterior descending artery (LAD), including distal diagonal branch, when comparing women with irradiated left-sided BC to those with right-sided. An increase of clinically significant coronary artery stenosis was found in pre-specified hotspot areas for radiation among women irradiated to the left breast/chest wall or to the IMC. Thus, the coronary arteries should be regarded as organs at risk in RT of BC.In a study of 15 BC patients treated with 3D conformal RT, a marked difference in dose distribution in mid and distal LAD between left- and right-sided BC was demonstrated. Irradiated right-sided BC mainly received low doses of scattered and transmitted radiation to the coronary arteries. On the contrary, tangential RT to the left breast without regional lymph node irradiation yielded coronary artery max doses of approximately 50 Gray to distal LAD, probably not safe concerning late radiation vascular effects.To conclude, we found cardiovascular side effects in women irradiated for BC, resulting in stroke and coronary artery disease, and showed an association between the targets for RT and the anatomical location of these vascular events.
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| 31. |
- Nilsson, Greger, et al.
(författare)
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Distribution of Coronary Artery Stenosis After Radiation for Breast Cancer
- 2012
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:4, s. 380-386
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE To study distribution of coronary artery stenosis among patients with breast cancer (BC) and to assess correlation between radiotherapy (RT) and location of stenosis. PATIENTS AND METHODS A Swedish BC cohort diagnosed from 1970 to 2003 was linked to registers of coronary angiography from 1990 to 2004, which yielded 199 patients. Stenoses of the coronary arteries were graded from 0 to 5, where 0 indicated a normal vessel and 5 indicated occlusion. Two hotspot areas for radiation were defined: proximal right coronary artery (prox RCA), mid and distal left anterior descending artery and distal diagonal (mdLAD + dD). RT regimens were categorized as high or low risk of irradiating the hotspot areas. Left breast/chest wall was considered high risk for mdLAD + dD; left internal mammary chain (IMC), high risk for prox RCA and mdLAD + dD from 1970 to 1995 and thereafter solely for mdLAD + dD; and right IMC, high risk for prox RCA. Other RT targets and no RT were considered low risk. Results were expressed in odds ratios (ORs) and 95% CIs. RESULTS For irradiated left- versus right-sided BC, the OR for grade 3 to 5 stenosis in mdLAD + dD was 4.38 (95% CI, 1.64 to 11.7), and for grade 4 to 5 stenosis, the OR was 7.22 (95% CI, 1.64 to 31.8). For high-risk RT versus low-risk or no RT, the OR for grade 3 to 5 stenosis in hotspot areas was 1.90 (95% CI, 1.11 to 3.24). CONCLUSION An increase of stenosis in mdLAD + dD in irradiated left-sided BC and an association between high-risk RT and stenosis in hotspot areas for radiation indicate a direct link between radiation and location of coronary stenoses.
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| 32. |
- Nilsson, Greger, et al.
(författare)
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Flow induced fiber orientation in compression molded glass mat thermoplastics
- 2000
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Ingår i: Polymer Composites. - : Wiley. - 0272-8397 .- 1548-0569. ; 21:6, s. 1007-1013
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Tidskriftsartikel (refereegranskat)abstract
- This study examines how the mechanical properties in GMT are affected by axisymmetric flow during compression molding. Two types of GMT with different architecture are used, swirled mat and short fiber GMT. Tree different grades are tested for each fiber architecture 20, 30, and 40% fiber content by weight. These are in principle the grades of GMT commercially available today. It is found that the flow reduced the tensile strength by 30 to 50% and the tensile modulus up to 30% in the flow direction. The reduction in mechanical properties, which is mainly caused by flow-induced fiber orientation, is larger at high fiber contents. The study also showed that there is no major difference in behavior between swirled mat and short fiber GMT regarding flow induced fiber orientation.
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| 33. |
- Nilsson, Greger, et al.
(författare)
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Increased incidence of stroke in women with breast cancer
- 2005
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 41:3, s. 423-429
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Tidskriftsartikel (refereegranskat)abstract
- Meta-analyses have shown an excess of vascular deaths in women with breast cancer given radiotherapy (RT). In women with breast cancer, RT to the supraclavicular lymph nodes gives a substantial radiation dose to the proximal carotid artery. RT is known to increase the risk of carotid stenosis and ischaemic stroke in head and neck cancer. A study base of 25,171 women with breast cancer was defined. A linkage between the study base and the Hospital Discharge Register yielded 1766 women who were diagnosed with a stroke after a breast cancer. The observed number of strokes was compared with the expected number in the background population. The Relative Risk (RR) of stroke in the study group with breast cancer was 1.12 (95% Confidence Interval (CI)=1.07-1.17). The increased risk was confined to the subtype cerebral infarction, RR=1.12 (95% CI=1.05-1.19). A statistically significant increase in the risk of stroke was seen among women with a history of breast cancer. Whether this risk is associated with the breast cancer disease per se or related to any treatment requires further study.
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| 34. |
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| 35. |
- Nilsson, Greger
(författare)
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Processing and properties of glass mat thermoplastics
- 2000
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The rapid processing of glass mat thermoplastics (GMT) is well known, large complex parts can be processed in less than one minute. It is however important that the material is produced properly to avoid a reduction in mechanical properties. There are some underlying industrial questions for this work. The first, how should the material be put in the mould and how does the flow affect the properties? The second question is if voids are detrimental for the mechanical performance of the material. The two papers of this thesis deal with some common problems during processing of GMT. Effects of variables such as voids, fibre orientation and fibre content variations on properties have been studied. Paper I deals with the flow during the mould-filling step. The work focused on the effect of flow on mechanical properties for two commercial GMT materials. The influence of variations in fibre orientation and fibre content are included. The stiffness has been measured for both specimens moulded with or without flow during compression. The result shows that flow has a significant effect on fibre orientation which in turn has a great effect on the mechanical properties. The fibre content seems to be more or less unaffected by the flow for the tested geometry. Paper II deals with another typical problem during GMT processing which is the presence of voids. To examine the effect voids on properties, materials with different void contents have been moulded. The effect of voids on damage initiation and propagation is investigated and the results show that voids are not a large problem in GMT. Cracks propagate in the same manner in void rich as in void free materials.
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| 36. |
- Nilsson, Greger, et al.
(författare)
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Radiation dose distribution in coronary arteries in breast cancer radiotherapy
- 2016
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 55:8, s. 959-963
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Tidskriftsartikel (refereegranskat)abstract
- Background: Women irradiated for left-sided breast cancer (BC) have an increased risk of coronary artery disease compared to women with right-sided BC. We describe the distribution of radiation dose in segments of coronary arteries in women receiving adjuvant radiotherapy (RT) for left- or right-sided BC.Material and methods: Fifteen women with BC, seven left-sided and eight right-sided, who had received three-dimensional conformal radiotherapy (3DCRT), constituted the study base. The heart and the segments of the coronary arteries were defined as separate organs at risk (OAR), and the mean and maximum radiation doses were calculated for each OAR.Results: In women with left-sided BC, irrespective of if regional lymph node RT was given or not, maximum dose in mid and distal left anterior descending artery (mdLAD) was approximately 50Gy in 6/7 patients, whereas women with right-sided BC mainly received low doses of radiation. In women with left-sided BC, 6/7 patients had substantially higher mean dose to the distal LAD than to the heart, ranging from 30 to 55Gy and 3 to13Gy, respectively.Conclusion: We found a pronounced difference of radiation dose distribution in the coronary arteries between women with left- and right-sided BC. Women with left-sided BC had almost full treatment dose in parts of mdLAD, regardless of if regional lymph node irradiation was given or not, while women with right-sided BC mainly received low doses to the coronary arteries.
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| 37. |
- Nilsson, Greger, et al.
(författare)
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Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke
- 2009
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 100:5, s. 811-816
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a Swedish BC cohort diagnosed during 1970-2003, we carried out a nested case-control study of stroke after BC, with relevant details extracted from medical records. The odds ratio (OR) for radiotherapy (RT) vs that of no RT did not differ between cases and controls (OR=0.85; confidence interval, CI=0.6-1.3). Radiotherapy to internal mammary chain (IMC) and supraclavicular (SCL) lymph nodes vs that of no RT was associated with a higher, although not statistically significant, risk of stroke (OR=1.3; CI=0.8-2.2). In a pooled analysis, RT to IMC and SCL vs the pooled group of no RT and RT to breast/chest wall/axilla (but not IMC and SCL), showed a significant increase of stroke (OR=1.8; CI=1.1-2.8). There were no associations between cancer laterality, targets of RT, and location of stroke. The radiation targets, IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose. Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke.
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| 38. |
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| 39. |
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| 40. |
- Nilsson, Thomas, et al.
(författare)
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A collision detection method for multicast transmissions in CSMA/CA networks
- 2007
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Ingår i: Wireless Communications & Mobile Computing. - : Wiley. - 1530-8669 .- 1530-8677. ; 7:6, s. 795-808
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Tidskriftsartikel (refereegranskat)abstract
- Compared to unicast traffic, multicast is not protected by any ARQ mechanism in 802.11 networks: collisions with other multicast and unicast transmissions are not detected and senders will not adapt to the contention situation by backing off. This results in an unreliable service for multicast transmissions. We propose early multicast collision detection (EMCD), an algorithm with the purpose of increasing the reliability of multicast transmissions in the MAC layer of an IEEE 802.11 network. A multicast sender using it will introduce an early pause in a transmission, perform a clear channel assessment (CCA), and if a collision is detected abort the transmission after a fixed time and schedule a retransmission. This allows for detecting collisions with both multicast and unicast transmissions but also adapting to the contention situation. A probabilistic analysis is provided showing that EMCD is more efficient than ordinary multicast and can be made even more efficient by tuning parameters.
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| 41. |
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| 42. |
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| 43. |
- Olander, Susanne, et al.
(författare)
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Angiosarcoma in the breast: a population-based cohort from Sweden
- 2023
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Ingår i: British Journal of Surgery. - : Oxford University Press. - 0007-1323 .- 1365-2168. ; 110:12, s. 1850-1856
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Tidskriftsartikel (refereegranskat)abstract
- Background: Breast angiosarcoma is a rare disease mostly observed in breast cancer (BC) patients who have previously received radiotherapy (RT). Little is known about angiosarcoma aetiology, management, and outcome. The study aim was to estimate risk and to characterize breast angiosarcoma in a Swedish population-based cohort. Methods: The Swedish Cancer Registry was searched for breast angiosarcoma between 1992 and 2018 in three Swedish healthcare regions (population 5.5 million). Information on previous BC, RT, management, and outcome were retrieved from medical records. Results: Overall, 49 angiosarcomas located in the breast, chest wall, or axilla were identified, 8 primary and 41 secondary to BC treatment. Median age was 51 and 73 years, respectively. The minimum latency period of secondary angiosarcoma after a BC diagnosis was 4 years (range 4–21 years). The cumulative incidence of angiosarcoma after breast RT increased continuously, reaching 1.4‰ after 20 years. Among 44 women with angiosarcoma treated by surgery, 29 developed subsequent local recurrence. Median recurrence-free survival was 3.4 and 1.8 years for primary and secondary angiosarcoma, respectively. The 5-year overall survival probability for the whole cohort was 50 per cent (95 per cent c.i., 21 per cent–100 per cent) for primary breast angiosarcoma and 35 per cent (95 per cent c.i., 23 per cent–54 per cent) for secondary angiosarcoma. Conclusion: Breast angiosarcoma is a rare disease strongly associated with a history of previous BC RT. Overall survival is poor with high rates of local recurrences and distant metastasis.
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| 44. |
- Olofsson, Kurt, et al.
(författare)
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New TailCast manufacturing process
- 2012
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Konferensbidrag (refereegranskat)abstract
- A new material- and manufacturing concept has been developed in the ongoing EU research project COMETA. The concept is called Tailored Reinforcement for Epoxy Casting (TailCast). TailCast uses a pre-consolidated grid structure made of continuous fibers, which is loaded as an insert into a conventional casting process. The resulting material- and product structure can hence be designed to incorporate a tailored reinforcement package of continuous fibers, short fibers and particles. This paper deals with material- and process developments towards a low Coefficient of Thermal Expansion (CTE) as well as the manufacture of a flange demonstrator for COMETA. The gained low composite CTE will furthermore reduce the sensitivity to humidity, which is important for this application.
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| 45. |
- Rask, Gunilla, et al.
(författare)
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Correlation of tumour subtype with long-term outcome in small breast carcinomas: a Swedish population-based retrospective cohort study
- 2022
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 195:3, s. 367-377
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To investigate if molecular subtype is associated with outcome in stage 1 breast cancer (BC). Methods Tissue samples from 445 women with node-negative BC <= 15 mm, treated in 1986-2004, were classified into surrogate molecular subtypes [Luminal A-like, Luminal B-like (HER2-), HER2-positive, and triple negative breast cancer (TNBC)]. Information on treatment, recurrences, and survival were gathered from medical records. Results Tumour subtype was not associated with overall survival (OS). Luminal B-like (HER2-) and TNBC were associated with higher incidence of distant metastasis at 20 years (Hazard ratio (HR) 2.26; 95% CI 1.08-4.75 and HR 3.24; 95% CI 1.17-9.00, respectively). Luminal B-like (HER2-) and TNBC patients also had worse breast cancer-specific survival (BCSS), although not statistically significant (HR 1.53; 95% CI 0.70-3.33 and HR 1.89; 95% CI 0.60-5.93, respectively). HER2-positive BC was not associated with poor outcome despite no patient receiving HER2-targeted therapy, with most of these tumours being ER+. Conclusions Stage 1 TNBC or Luminal B-like (HER2-) tumours behave more aggressively. Women with HER2+/ER+ tumours do not have an increased risk of distant metastasis or death, absent targeted treatment.
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| 46. |
- Sundh, Josefin, 1972-, et al.
(författare)
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Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) - Study protocol from a randomized controlled trial
- 2020
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Ingår i: Trials. - : BioMed Central (BMC). - 1745-6215. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Observational studies indicate that beta-blockers are associated with a reduced risk of exacerbation and mortality in patients with chronic obstructive pulmonary disease (COPD) even without overt cardiovascular disease, but data from randomized controlled trials (RCT) are lacking. The aim of this RCT is to investigate whether beta-blocker therapy in patients with COPD without diagnosed cardiovascular disease is associated with a decreased 1-year risk of the composite endpoint of death, exacerbations, or cardiovascular events.Methods: The Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) study is an open-label, multicentre, prospective RCT. A total of 1700 patients with COPD will be randomly assigned to either standard COPD care and metoprolol at a target dose of 100 mg per day or to standard COPD care only. The primary endpoint is a composite of death, COPD exacerbations, and cardiovascular events. Major exclusion criteria are ischemic heart disease, left-sided heart failure, cerebrovascular disease, critical limb ischemia, and atrial fibrillation/flutter. Study visits are an inclusion visit, a metoprolol titration visit at 1 month, follow-up by telephone at 6 months, and a final study visit after 1 year. Outcome data are obtained from medical history and record review during study visits, as well as from national registries.Discussion: BRONCHIOLE is a pragmatic randomized trial addressing the potential of beta-blockers in patients with COPD. The trial is expected to provide relevant clinical data on the efficacy of this treatment on patient-related outcomes in patients with COPD.
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| 47. |
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| 48. |
- Söderberg, Emma, et al.
(författare)
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Association of clinicopathologic variables and patient preference with the choice of surgical treatment for early-stage breast cancer : A registry-based study
- 2024
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Ingår i: Breast. - : Elsevier. - 0960-9776 .- 1532-3080. ; 73
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Observational studies suggest that breast conserving surgery (BCS) and radiotherapy (RT) offers superior survival compared to mastectomy. The aim was to compare patient and tumour characteristics in women with invasive breast cancer <= 30 mm treated with either BCS or mastectomy, and to explore the underlying reason for choosing mastectomy.Methods: Women registered with breast cancer <= 30 mm and <= 4 positive axillary lymph nodes in the Swedish National Breast Cancer Register 2013-2016 were included. Logistic regression analyses were performed to assess the association of tumour and patient characteristics with receiving a mastectomy vs. BCS.Results: Of 1860 breast cancers in 1825 women, 1346 were treated by BCS and 514 by mastectomy. Adjuvant RT was given to 1309 women (97.1 %) after BCS and 146 (27.6 %) after mastectomy. Variables associated with receiving a mastectomy vs. BCS included clinical detection (Odds Ratio (OR) 4.15 (95 % Confidence Interval (CI) 3.35-5.14)) and clinical stage (T2 vs. T1 (OR 3.68 (95 % CI 2.90-4.68)), N1 vs. N0 (OR 2.02 (95 % CI 1.38-2.96)). Women receiving mastectomy more often had oestrogen receptor negative, HER2 positive tumours of higher histological grade. The most common reported reason for mastectomy was large or multifocal tumours (53.5 %), followed by patient preference (34.5 %).Conclusion: Choice of surgery is strongly associated with key prognostic factors among women undergoing BCS with RT compared to mastectomy. Failure to control for all relevant confounders may bias results in outcome studies in favour of BCS.
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| 49. |
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| 50. |
- Thornell, Greger, et al.
(författare)
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Desktop microfabrication : initial experiments with a piezoceramic
- 1999
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Ingår i: Journal of Micromechanics and Microengineering. - : IOP Publishing. - 0960-1317 .- 1361-6439. ; 9:4, s. 434-437
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Tidskriftsartikel (refereegranskat)abstract
- A method for building microstructures from a suspension of micrometre-sized piezoelectric particles by depositing droplets on top of droplets and promoting drying is devised. A micromachined dispensing unit similar to a drop-on-demand inkjet-printer head is used. The relation of the vertical building rate to the ejection frequency and the substrate temperature is established, and a mechanism explaining the tubular structures built is proposed.
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