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1.	Abarkan, Abdellah, et al. (författare) Lyssna på forskningen : Den visar på avregleringens problem 2019 Ingår i: Dagens nyheter. - Stockholm : Dagens nyheter. - 1101-2447. ; :10/21/2019 Tidskriftsartikel (populärvet., debatt m.m.)
2.	Klionsky, Daniel J, et al. (författare) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016 Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 12:1, s. 1-222 Tidskriftsartikel (refereegranskat)
3.	Nilsson, Abraham, et al. (författare) Improved and sustained triage skills in firemen after a short training intervention 2015 Ingår i: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. - : BIOMED CENTRAL LTD. - 1757-7241. ; 23:81, s. 1-6 Tidskriftsartikel (refereegranskat)abstract Background: A previous study has shown no measurable improvement in triage accuracy among physicians attending the Advanced Trauma Life Support (ATLS) course and suggests a curriculum revision regarding triage. Other studies have indicated that cooperative learning helps students acquire knowledge. Objective: The present study was designed to evaluate the effectiveness of trauma cards in triage training for firemen. Methods: Eighty-six firemen were randomly assigned into two groups: the trauma card group and the direct instruction group. Both groups received the same 30-min PowerPoint lecture on how to perform triage according to the Sort Assess Lifesaving interventions Treatment and transport (SALT) Mass Casualty Triage Algorithm. In the trauma card group, the participants were divided into groups of 3-5 and instructed to triage 10 trauma victims according to the descriptions on the trauma cards. In the direct instruction group, written forms about the same 10 victims were used and discussed as a continuation of the PowerPoint lecture. Total training time was 60 min for both groups. A test was distributed before and after the educational intervention to measure the individual triage skills. The same test was applied again 6 months later. Results: There was a significant improvement in triage skills directly after the intervention and this was sustained 6 months later. No significant difference in triage skills was seen between the trauma card group and the direct instruction group. Previous experience of multi-casualty incidents, years in service, level of education or age did not have any measurable effects on triage accuracy. Conclusions: One hour of triage training with the SALT Mass Casualty Triage Algorithm was enough to significantly improve triage accuracy in both groups of firemen with sustained skills 6 months later. Further studies on the first assessment on scene versus patient outcome are necessary to provide evidence that this training can improve casualty outcome. The efficacy and validity of trauma cards for disaster management training need to be tested in future studies.
4.	Pontén, Fredrik, et al. (författare) Ubiquitous protein expression in human cells, tissues and organs Annan publikation (övrigt vetenskapligt/konstnärligt)
5.	Porritt, Michelle J, et al. (författare) Photothrombosis-Induced Infarction of the Mouse Cerebral Cortex Is Not Affected by the Nrf2-Activator Sulforaphane 2012 Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7 Tidskriftsartikel (refereegranskat)abstract Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of focal cerebral ischemia. However, its ability to attenuate functional and cellular deficits after permanent focal cerebral ischemia is not clear. We assessed the neuroprotective effects of sulforaphane in the photothrombotic model of permanent focal cerebral ischemia. Sulforaphane was administered (5 or 50 mg/kg, i.p.) after ischemic onset either as a single dose or as daily doses for 3 days. Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system. Single or repeated administration of sulforaphane had no effect on the infarct volume, nor did it reduce the number of activated glial cells or proliferating cells when analyzed 24 and 72 h after stroke. Motor-function as assessed by beam-walking, cylinder-test, and adhesive test, did not improve after sulforaphane treatment. The results show that sulforaphane treatment initiated after photothrombosis-induced permanent cerebral ischemia does not interfere with key cellular mechanisms underlying tissue damage.
6.	Schultze, Felix, 1958- (författare) Coteaching chemical bonding with Upper secondary senior students : A way to refine teachers PCK 2018 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract The aim of this study was to investigate how an experienced chemistry teacher gains and refines her pedagogical content knowledge (PCK) by cooperating with two grade 12 students (age 18) as coteachers while teaching chemical bonding in a grade 10 Upper secondary class. The study has been conducted from a sociocultural perspective, especially Vygotsky’s zone of proximal development (ZPD) (Vygotsky, 1978). Other theoretical concepts and models that has framed this study are Shulman´s Pedagogical content knowledge (PCK) and Pedagogical reasoning and action model (Shulman, 1986, 1987). When analysing the data, Magnusson, Krajcik, and Borko´s (1999) model of PCK and the 2017 Refined consensus model of PCK (Carlson, Daehler, et al., in press) was used. Empirical data was collected by video- and audio recorded lessons, coreflection sessions, coplanning sessions and interviews. During 10 weeks, about 28 hours of video and audio recordings was collected. Selected parts of the material were transcribed and analysed in order to answer two questions: (1) How can chemistry teachers refine their PCK when coteaching together with senior students in an Upper secondary science class? (2) How do Upper secondary senior student coteachers´ conceptual knowledge of representations and chemical bonding shape a teacher’s foundation of personal PCK (pPCK) when teaching chemical bonding in an Upper secondary science class?The results relating to research question one indicates that the coteachers contributed with their own learning experiences to help the teacher understand how students perceive difficult concepts. The coteachers were mediating between the teacher and the students, thus bridging the gap between the teacher and the students’ frames of references. The experienced chemistry teacher improved her understanding of students´ thinking about themselves as learners of chemical bonding. Regarding the second research question, the findings showed that the creative process of reconstructing concepts of chemical bonding in the coplanning sessions meant that these were a useful tool for developing new teaching strategies and to further develop representations such as drama to illustrate chemical bonding. Together, the teacher and student coteachers, constructed a new representation that better illustrated polar covalent bonding.Taken together, these results provide important insights into how the chemistry teacher´s pPCK was refined and how the coteachers contributed to improve instructional strategies.
7.	Zimmerman Nilsson, Marie-Helene, 1967-, et al. (författare) Does content matter? : Developing preschool teachers' pedagogical content knowledge in music education 2018 Ingår i: The Finnish Journal of Music Education. - Helsingfors : Sibelius Academy. - 1239-3908 .- 2342-1150. ; 21:1, s. 25-38 Tidskriftsartikel (refereegranskat)
8.	Zimmerman Nilsson, Marie-Helene, 1967-, et al. (författare) From Pedagogical Knowledge to Pedagogical Content Knowledge : Development in Mentor and Student-Teacher Group Conversations 2019 Ingår i: International Journal of Learning, Teaching and Educational Research. - Port Louis : Tresorix Ltd. - 1694-2493 .- 1694-2116. ; 18:10, s. 233-247 Tidskriftsartikel (refereegranskat)abstract This case study focuses on mentor group conversation meetings with primary student-teachers, demonstrating how student-teachers ́ reflections on classroom experiences might influence their understanding of the complicated relationship between teaching, subject matter content and the context. The aim is to study how mentors ́ and student-teachers ́ reflections affect (or not) the student-teachers ́ development of pedagogical content knowledge (PCK). The theoretical framework derives from a sociocultural perspective, emphasising the collective character of teaching and learning. The empirical material consists of video documented mentor group conversations during one semester within an academic school context. Findings show development of PCK, highlighting a transition from pedagogical knowledge and contextual knowledge, to a blending of subject matter knowledge, pedagogical knowledge and contextual knowledge. This blending only occurred when the student teachers reflected on their teaching. Findings demonstrate the need to systematically explore student-teacher reflections of their teaching in practice to discern how different knowledge bases integrate into PCK. ©2019 The authors and IJLTER.ORG. All rights reserved.
9.	Zimmerman Nilsson, Marie-Helene, 1967-, et al. (författare) Teaching in a digital learning platform : A case study of how second language English teachers express their Technological Pedagogical Content Knowledge (TPACK) during collegial reflections 2018 Ingår i: ICERI2018 Proceedings. - : The International Academy of Technology, Education and Development. - 9788409059485 ; , s. 9366-9371 Konferensbidrag (refereegranskat)abstract During the last decade, digital technologies have been more and more integrated into teachers´ classroom practice. Perceptions of knowledge and the teacher´s role might change when digital resources are introduced in the classroom - regardless of the subject. As a consequence, teachers might reconsider the concept of learning in educational contexts. Despite a vast number of studies from a Technological pedagogical content knowledge (TPACK) perspective, there is still a need for studies that focus on how TPACK develops among teachers. Thus, the aim of this case study is to explore how three teachers´ Technological pedagogical content knowledge (TPACK) is expressed during a second language English project in secondary school. The research question is: How are teachers´ components of TPACK expressed and integrated within their reflections on their teaching in a second language English project with a digital learning platform? The theoretical framework is based on Pedagogical Content Knowledge (PCK) and more specifically on technological pedagogical content knowledge (TPACK), which is essential to this study. The empirical data consists of video recorded stimulated recall group interviews and the analysis is inspired by the structures of content analysis. The research context was a compulsory school situated near a larger town. The school had a special license with a digital learning company that provided a digital learning management system called Digital learning platform (DLP), that offered opportunities to arrange teaching projects digitally. The results show that several combined components of TPACK are present in teachers´ reflections on their teaching; Technological pedagogical knowledge (TPK), Technological content knowledge (TCK), and Pedagogical content knowledge (PCK). The way in which these components appear seems to depend on the phase in the project. Thus, when planning the project, expressions of TPACK are characterised by suggestions of how to use the Digital Learning Platform (DPL), whereas reflections after teaching were characterised by analysing the use of the DPL related to advantages or disadvantages for students´ learning processes. Overall, the teachers´ reflections on their teaching developed, where components of TPACK related to functions in the DPL after the project were referred to in a more deepened and differentiated way. In summary, discussions and reflections with regard to the possibilities and limitations for learning with the use of DPL in school and important questions concerning teachers´ digital competence were elucidated. As such, the result of this study might create a discussion of and recommendations for how teachers choose, combine, implement, and evaluate digital technologies for different teaching and learning situations.
10.	Zimmerman Nilsson, Marie-Helene, 1967-, et al. (författare) When Content Matters - Capturing and Developing Preschool Student Teachers´ Pedagogical Content Knowledge in Music 2017 Ingår i: ABSTRACTS. ; , s. 37-37 Konferensbidrag (refereegranskat)abstract This study focuses on a group of preschool student teachers´ reflections of their Pedagogical Content Knowledge (PCK) during a 10-week music methods course. The student teachers created Content Representations (CoRe) when planning before and reflecting after their music lessons in a preschool context. The analysis of written reflections in CoRe protocols about the teaching of “Dynamics” indicates changes in focus between CoRe 1 and CoRe 2, suggesting a development of PCK. More specifically it was a progress from children gaining experience to children´s understanding, from teaching strategies to children´s learning, and from the teacher governing the activity to involve children collaboration. In conclusion, this approach to enhancing preschool teachers´ professional development in music adapting a CoRe based methodology has a promising potential to make their PCK more explicit and elaborate.
11.	Adini, B., et al. (författare) Policies for managing emergency medical services in mass casualty incidents 2017 Ingår i: Injury. - : ELSEVIER SCI LTD. - 0020-1383 .- 1879-0267. ; 48:9, s. 1878-1883 Tidskriftsartikel (refereegranskat)abstract Introduction: Diverse decision-making is needed in managing mass casualty incidents (MCIs), by emergency medical services (EMS). The aim of the study was to review consensus among international experts concerning policies of EMS management during MCIs. Methods: Applicability of 21 EMS policies was tested through a 2-cycle modified e-Delphi process, in which 38 multi-disciplinary experts from 10 countries participated. Threshold for approving proposed solutions was defined as consensus of amp;gt;80%. Policies that did not achieve the targeted consensus were reviewed to detect variability according to respondents origin country. Results: 16 policies were endorsed in the first cycle including collaboration between ambulance service providers; implementing a unified mode of operation; preparing criteria for ground versus aerial evacuation; and, developing support systems for caregivers exposed to violence. An additional policy which proposed that senior EMS officers should not necessarily act as on-site MCI commanders was endorsed in the second cycle. Demographic breakdown of views concerning non-consensual policies revealed differences according to countries of origin. Assigning ambulances to off-duty team members was highly endorsed by experts from Israel and South Africa and strongly rejected by European respondents. Avoiding entry to risk areas until declared safe was endorsed by European, Asian and Oceanic experts, but rejected by Israeli, South African and North American experts. Conclusions: Despite uniqueness of countries and EMS agencies, solutions to most dilemmas were applicable to all organizations, regardless of location or affiliation. Cultural diversity was found concerning readiness to implement military-civilian collaboration in MCIs and a rigid separation between work-leisure responsibilities. (C) 2017 Elsevier Ltd. All rights reserved.
12.	Ahmadian, Afshin, et al. (författare) SNP analysis by allele-specific extension in a micromachined filter chamber 2002 Ingår i: BioTechniques. - : Future Science Ltd. - 0736-6205 .- 1940-9818. ; 32:4, s. 748-754 Tidskriftsartikel (refereegranskat)
13.	Almlöf Ambjörnsson, Heléne, 1968- (författare) Mercerization and Enzymatic Pretreatment of Cellulose in Dissolving Pulps 2013 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis deals with the preparation of chemically and/or enzymatically modified cellulose. This modification can be either irreversible or reversible. Irreversible modification is used to prepare cellulose derivatives as end products, whereas reversible modification is used to enhance solubility in the preparation of regenerated cellulose.The irreversible modification studied here was the preparation of carboxymethyl cellulose (CMC) using extended mercerization of a spruce dissolving pulp. More specifically the parameters studied were the effect of mercerization at different proportions of cellulose I and II in the dissolving pulp, the concentration of alkali, the temperature and the reaction time. The parameters evaluated were the degree of substitution, the filterability and the amount of gel obtained when the resulting CMC was dissolved in water. Molecular structures of CMC and its gel fractions were analysed by using NIR FT Raman spectroscopy. It was found that the alkali concentration in the mercerization stage had an extensive influence on the subsequent etherification reaction. FT Raman spectra of CMC samples and their gel fractions prepared with low NaOH concentrations (9%) in the mercerization stage indicated an incomplete transformation of cellulose to Na-cellulose before carboxymethylation to CMC. Low average DS values of the CMC, i.e. between 0.42 and 0.50 were obtained. Such CMC dissolved in water resulted in very thick and semi solid gum-like gels, probably due to an uneven distribution of substituents along the cellulose backbone. FT Raman spectra of CMC samples and their gel fractions mercerized at higher alkaline concentration, i.e. 18.25 and 27.5% in the mercerization stage, indicated on the other hand a complete transformation of cellulose to Na-cellulose before carboxymethylation to CMC. Higher average DS values of the CMC, i.e. between 0.88 and 1.05 were therefore obtained. When dissolved in water such CMC caused gel formation especially when prepared from dissolving pulp with a high fraction of cellulose II.The reversible modification studied was the dissolution of cellulose in NaOH/ZnO. Here the effect of enzyme pretreatment was investigated by using two mono-component enzymes; namely xylanase and endoglucanase, used in consecutive stages. It was found that although the crystallinity and the specific surface area of the dissolving pulp sustained minimal change during the enzymatic treatment; the solubility of pulp increased in a NaOH/ZnO solution from 29% for untreated pulp up to 81% for enzymatic pretreated pulp.
14.	Andersson, Helene, et al. (författare) A valve-less diffuser micropump for microfluidic analytical systems 2001 Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 72:3, s. 259-265 Tidskriftsartikel (refereegranskat)abstract The suitability of valve-less micropumps in biochemistry has been shown. Fluids encountered in various biochemical methods that are problematic for other micropumps have been pumped with good performance. The pump is fabricated as a silicon-glass stack with a new process involving three subsequent deep reactive ion etching steps. Some of the main advantages of the valve-less diffuser pump are the absence of moving parts (excluding the pump diaphragm), the uncomplicated planar design, and high pump performance in terms of pressure head and flow rare. In addition, the micropump is self-priming and insensitive to particles and bubbles present in the pumped media. The results show that the valve-less micropump successfully pumps fluids within the viscosity range of 0.001-0.9 N s/m(2). The micropump is not sensitive to the density, ionic strength, or pH of the pumped media. Effective pumping of solutions containing beads of different sizes was also demonstrated. Living cells were pumped without inducing cell damage and no cell adhesion within the pump chamber was found. No valve-less micropump has previously been reported to pump such a wide variety of fluids.
15.	Andersson, Helene, et al. (författare) A Valve-Less Diffuser Micropump for Microfluidic Analytical Systems 2001 Ingår i: Sensors and Actuators B: Chemical. ; :72, s. 259-265 Tidskriftsartikel (refereegranskat)
16.	Andersson, Helene, et al. (författare) A Valve-Less Diffuser Micropump for Microfluidic Analytical Systems 2000 Ingår i: µTAS, Enschede, The Netherlands, May 14-18 (2000). Konferensbidrag (refereegranskat)
17.	Andersson, Helene, et al. (författare) Micromachined Flow-Through Filter-Chamber for Solid Phase DNA Analysis 2000 Ingår i: µTAS, Enschede, The Netherlands, May 14-18 (2000). Konferensbidrag (refereegranskat)
18.	Andersson, Heléne, 1973, et al. (författare) Trauma-induced reactive gliosis is reduced after treatment with octanol and carbenoxolone 2011 Ingår i: Neurological research. - 0161-6412. ; 33:6, s. 614-624 Tidskriftsartikel (refereegranskat)abstract Background: Reactive gliosis and scar formation after brain injury can inhibit the recovery process. As many glial cells utilize gap junctions for intercellular signaling, this study investigated whether two commonly used gap junction blockers, octanol and carbenoxolone, could attenuate reactive gliosis following a minor traumatic brain injury. Methods: Octanol (710 mg/kg) or carbenoxolone (90 mg/kg) was administered 30 minutes before or after a needle track injury in adult male Sprague-Dawley rats. To mark dividing cells, animals were injected with bromodeoxyuridine (BrdU; 150 mg/kg) intraperitoneally two times per day, 8 hours apart and killed 2 days later. Immunohistochemistry for BrdU and markers for reactive glial cells [glial fibrillary acidic protein (GFAP), ED1, and NG2] were investigated using immunohistochemistry and western blot techniques. Results: Two days after injury, increased cellular proliferation, activated astrocytes and microglia, and upregulation of NG2 expression were observed surrounding the injury site. Octanol and carbenoxolone administrated prior to injury significantly decreased cell proliferation by 60 and 70% respectively. The distance of GFAP immunoreactive astrocytes from the wound margin was decreased by 32 and 18% when octanol was administrated prior to or post injury respectively. Treatment with octanol also decreased the number of reactive microglia by 55% and, when administrated prior to injury, octanol reduced the distance of NG2 expression from the wound by 48%. Conclusion: The present study demonstrates that two important components of reactive gliosis, cellular activation and proliferation, can be attenuated by octanol and carbenoxolone.
19.	Berggren, Peter, 1971-, et al. (författare) The importance of using the designated duty officers when assessing the medical response organization 2017 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract BackgroundAn important aspect of disaster medicine is to be proactive and respond quickly when disaster strikes. In Sweden, the role responsible for swift medical response on the regional level is the designated duty officer.MethodsA large exercise to assess national medical response ability was conducted. Seven medical regional staffs (a total of 93 individuals participated as tested participants) were involved in handling a large train accident scenario. The exercise was run for 5 hours, where the different regional staffs were located at their regular command posts. The exercise was organized using Emergo Train Systems.ResultsSeveral capabilities were identified during the exercise as important for the organization to maintain the ability to handle a similar event: documentation and operational picture, communication and terminology, command of resources, strategy for distribution of resources, national co-ordination, and exercise development.The designated duty officers were central to the exercise in several aspects: 1) in developing and verifying a realistic scenario and preparing background information, 2) as participants in the exercise, 3) assessors of the staffs’ behaviors, and 4) as domain experts when interpreting the exercise outcome.ConclusionsUsing subject matter experts is central to many research domains. However, the more complex a situation is the larger the demand of expertise is. The technical platform allows for coordinating complex exercises, whereas the subject matter expert in terms of the designated duty officer is required to guarantee validity and reliability in these large-scale exercises.Key messages:Running complex scenarios to train and test abilities requires subject matter experts in both planning, preparation, implementation, and assessment.Sophisticated simulator and training platforms, such as Emergo Train Systems, facilitates while the designated duty officers are necessary to guarantee validity and reliability in the exercise.
20.	Bergström, Petra, et al. (författare) Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage 2011 Ingår i: NEUROPHARMACOLOGY. - 0028-3908. ; 60:2-3, s. 343-353 Tidskriftsartikel (refereegranskat)
21.	Borgström Källén, Carina, 1961, et al. (författare) A new take on gender imbalances in music education - collaboratory visions for equal musical becomings 2023 Ingår i: RIME2023: RESEARCH IN MUSIC EDUCATION (RIME) 2023. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract ABSTRACT. Gender equal accessibility to a diverse musical learning in schools is a well-recognized problem in western music education. A body of research, from a range of theoretical and methodological perspectives, shows that stereotyped gender patterns still affect musical performances in the contemporary music classroom. So far, efforts to solve this problem in practice have been deficient. As there is a lack of studies with a post-human perspective within the area, the aim of this presentation is to focus on gender imbalance in music education from this approach. Based on an ongoing study, we explore practitioners’ visions of a future gender equal classroom from a post-human perspective. More specifically, the presentation focuses on a pilot study, where participants were asked to imagine a future music classroom, offering new possible becomings for gender equal music education. The music classroom was viewed as actor-networks, existing of human-, socio-cultural - and non-human actors. Visual ethnography and arts-based research constituted the methodological approach. The explorative design implied involving participants in reflection-based interviews and collaborative creative activities. Visions of gender equal future music classrooms were envisioned by music practitioners, via an online communication tool. The findings reveal that new possibilities for gender equal musical becomings depend on diverse socio-material, material- and human entanglements in the music classroom, implying that actors, such as rooms, spaces, instruments, furniture, humans and computers, impact on gender imbalance. In conclusion, gender equality in music education practices might be improved by a post-human approach.
22.	Borgström Källén, Carina, 1961, et al. (författare) A posthuman future music classroom for increased equality - a pilot study : A posthuman future music classroom for increased equality - a pilot study 2022 Ingår i: Nordic Network for Research in Music Education Conference 2022. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract A posthuman future music classroom for increased equality - a pilot study Marie-Helene Zimmerman Nilsson, University West; Carina Borgström Källén, School of Music and Drama, Gothenburg University; Cecilia Ferm Almqvist, Södertörn University Keywords: post humanism, music education, equality, classroom, future The school as an institution is inert and changes slowly. In contrast, the contemporary postmodern society in the West is characterized by mobility, change and unpredictability. Students of tomorrow, digital natives raised in a Western postmodern society, represent different genders and different social, cultural and knowledge-based backgrounds and demand a teaching flexibility in school music. Nevertheless, research shows that contemporary Swedish school music insufficiently challenges current unequal traditions (Onsrud et al. 2021), especially regarding stereotyped performance of gender in relation to accessibility for all pupils to all kinds of musical learning. Hence, this ongoing project focuses on how Swedish school music can be changed. The aim is to increase knowledge about how gender equal options for musical becoming can be realized in the future music classroom. The research questions are: What kind of significant actors and entanglements become visible in digitally created visions of a future gender equal music classroom? What kinds of musical becomings are encouraged by the music actors within the actor-networks of the visioned future gender equal musical classroom? What agencies are given to future music classroom human and non-human actors? The theoretical framework emanates from a socio-materialistic, post-human perspective (Ferrando, 2013). Of interest are both visions, experiences and values. Hence, visual ethnography (Pink 2021) and arts-based research (Barone & Eisner, 2012) constitute the methodological approach. This conference presentation will report on a pilot study where participants have produced joint visions for the future music classroom. The task for the participants in the pilot study was to discuss and create visions of the future gender equal musical classroom within the group. The participants’ communications were recorded, as well as the creative collaborative processes. The recordings were transcribed and subjected to ANT-analysis (Latour, 2005). Results concerning how the method worked as well as which actors that appeared as significant for the future music classroom will be presented in the conference presentation. References Barone, T., & Eisner, E. W. (2011). Arts based research. Sage. Ferrando, F. (2013). Posthumanism, Transhumanism, Antihumanism, Metahumanism, and New Materialisms Differences and Relations. Existenz, 8(2), 26-32. Latour, B. (2005). Reassembling the social: An introduction to actor–network-theory. Oxford: Oxford University Press. Onsrud V., S.,Lunde Vestad, I. & Blix, H.S. (Eds.) (2021). Gender Research in Scandinavian and Greek Music Education: From stereotypes to multiple possibilities?. Routledge, ISME-series. Pink, S. (2021). Doing Visual Ethnography. Sage.
23.	Borgström Källén, Carina, 1961, et al. (författare) Framtidens musikklassrum - en posthumanistisk ingång för ökad jämställdhet 2021 Ingår i: Child and Youth Studies Conference University West November 4-5 2021 THE CONVENTION OF THE RIGHTS OF THE CHILD Book. - 9789189325043 Konferensbidrag (refereegranskat)abstract Det övergripande syftet för detta konferensbidrag är att diskutera hur ett sociomateriellt-, posthumanistiskt perspektiv kan vidga potentialen för könsjämlika blivanden i framtidens musikklassrum. Skolan som institution förändras långsamt, i motsats till det samtida samhället som präglas av rörlighet, förändring och oförutsägbarhet. Dagens och framtidens barn och elever som växer upp i detta postmoderna samhälle representerar olika könstillhörigheter och olika sociala, kulturella och kunskapsmässiga bakgrunder. Detta gör att de också har krav på en mer flexibel undervisning. Av Barnkonventionens 29e artikel framgår det att syftet med utbildning är att “…förbereda barnet för ett ansvarsfullt liv i ett fritt samhälle i en anda av förståelse, fred, tolerans, jämställdhet mellan könen…” Musikpedagogisk forskning visar dock att musikundervisning fortfarande präglas av konservativa traditioner som underblåser ojämlikheter mellan könen. Skolans musikundervisning utmanar således inte i tillräcklig omfattning ojämlika traditioner. Mot bakgrund av detta fokuserar föreliggande forskningsprojekt på hur musikundervisning i skolan kan förändras genom att anlägga ett posthumanistiskt perspektiv på framtidens musikklassrum. Utifrån studiens posthumanistiska teoretiska ramverk betraktas det framtida musikklassrummet som ett aktörsnätverk bestående av mänskliga-, sociokulturella- och materiella aktörer, där barnet/eleven som aktör är en ständigt föränderlig del av dessa sammanflätningar.
24.	Bremer, Hanna, et al. (författare) ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease 2018 Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8 Tidskriftsartikel (refereegranskat)abstract Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previously described in dogs. Subsequently, ILF3 autoantibodies were also identified in the same cohort. The results were validated with an independent method in a larger cohort of dogs. ILF2 and ILF3 autoantibodies were found exclusively, and at a high frequency, in dogs that showed a speckled pattern of antinuclear antibodies on immunofluorescence. ILF2 and ILF3 autoantibodies were also found at low frequency in human patients with SLE and Sjogren's syndrome. These autoantibodies have the potential to be used as diagnostic biomarkers for canine, and possibly also human, autoimmune disease.
25.	Bungum, Ane Berger, et al. (författare) Risk of metabolic disorders in childless men : A population-based cohort study 2018 Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 8:8 Tidskriftsartikel (refereegranskat)abstract Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
26.	Caballero-Corbalán, José, et al. (författare) Vitacyte Collagenase HA : A Novel Enzyme Blend for Efficient Human Islet Isolation 2009 Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 88:12, s. 1400-1402 Tidskriftsartikel (refereegranskat)
27.	Cazelles, Kevin, et al. (författare) Homogenization of freshwater lakes : Recent compositional shifts in fish communities are explained by gamefish movement and not climate change 2019 Ingår i: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 25:12, s. 4222-4233 Tidskriftsartikel (refereegranskat)abstract Globally, lake fish communities are being subjected to a range of scale-dependent anthropogenic pressures, from climate change to eutrophication, and from overexploitation to species introductions. As a consequence, the composition of these communities is being reshuffled, in most cases leading to a surge in taxonomic similarity at the regional scale termed homogenization. The drivers of homogenization remain unclear, which may be a reflection of interactions between various environmental changes. In this study, we investigate two potential drivers of the recent changes in the composition of freshwater fish communities: recreational fishing and climate change. Our results, derived from 524 lakes of Ontario, Canada sampled in two periods (1965-1982 and 2008-2012), demonstrate that the main contributors to homogenization are the dispersal of gamefish species, most of which are large predators. Alternative explanations relating to lake habitat (e.g., area, phosphorus) or variations in climate have limited explanatory power. Our analysis suggests that human-assisted migration is the primary driver of the observed compositional shifts, homogenizing freshwater fish community among Ontario lakes and generating food webs dominated by gamefish species.
28.	David, Gregiore, et al. (författare) Using life cycle assessment to quantify the environmental benefit of upcycling vine shoots as fillers in biocomposite packaging materials 2021 Ingår i: The International Journal of Life Cycle Assessment. - : Springer Science and Business Media Deutschland GmbH. - 0948-3349 .- 1614-7502. ; 26, s. 738-752 Tidskriftsartikel (refereegranskat)abstract Purpose: The objective of the present study was to better understand the potential environmental benefit of using vine shoots (ViShs), an agricultural residue, as filler in composite materials. For that purpose, a comparative life cycle assessment (LCA) of a rigid tray made of virgin poly(3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV, polylactic acid (PLA) or polypropylene (PP), and increasing content of ViSh particles was performed. The contribution of each processing step in the life cycle on the different environmental impacts was identified and discussed. Furthermore, the balance between the environmental and the economic benefits of composite trays was discussed. Methods: This work presents a cradle-to-grave LCA of composite rigid trays. Once collected in vineyards, ViShs were dried and ground using dry fractionation processes, then mixed with a polymer matrix by melt extrusion to produce compounds that were finally injected to obtain rigid trays for food packaging. The density of each component was taken into account in order to compare trays with the same volume. The maximum filler content was set to 30 vol% according to recommendations from literature and industrial data. The ReCiPe 2016 Midpoint Hierarchist (H) methodology was used for the assessment using the cutoff system model. Results and discussion: This study showed that bioplastics are currently less eco-friendly than PP. This is in part due to the fact that LCA does not account for, in existing tools, effects of microplastic accumulation and that bioplastic technologies are still under development with low tonnage. This study also demonstrated the environmental interest of the development of biocomposites by the incorporation of ViSh particles. The minimal filler content of interest depended on the matrices and the impact categories. Concerning global warming, composite trays had less impact than virgin plastic trays from 5 vol% for PHBV or PLA and from 20 vol% for PP. Concerning PHBV, the only biodegradable polymer in natural conditions in this study, the price and the impact on global warming are reduced by 25% and 20% respectively when 30 vol% of ViSh are added. Conclusion: The benefit of using vine shoots in composite materials from an environmental and economical point of view was demonstrated. As a recommendation, the polymer production step, which constitutes the most important impact, should be optimized and the maximum filler content in composite materials should be increased. © 2020, The Author(s).
29.	Deland, Lily, et al. (författare) Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib 2021 Ingår i: Cancer Biology & Therapy. - : Taylor & Francis. - 1538-4047 .- 1555-8576. ; 22:3, s. 184-195 Tidskriftsartikel (refereegranskat)abstract Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a BRAF-negative pilocytic astrocytoma. Copy-number variation profiling of fresh frozen tumor material identified two duplications in 9q21.32–33 leading to breakpoints within the GKAP1 and NTRK2 genes. RT-PCR Sanger sequencing revealed a GKAP1-NTRK2 exon 10–16 in-frame fusion, generating a putative fusion protein of 658 amino acids with a retained tyrosine kinase (TK) domain. Functional analysis by transient transfection of HEK293 cells showed the GKAP1-NTRK2 fusion protein to be activated through phosphorylation of the TK domain (Tyr705). Subsequently, downstream mediators of the MAPK- and PI3K-signaling pathways were upregulated in GKAP1-NTRK2 cells compared to NTRK2 wild-type; phosphorylated (p)ERK (3.6-fold), pAKT (1.8- fold), and pS6 ribosomal protein (1.4-fold). Following these findings, the patient was enrolled in a clinical trial and treated with the specific TRK-inhibitor larotrectinib, resulting in the arrest of tumor growth. The patient’s condition is currently stable and the quality of life has improved significantly. Our findings highlight the value of comprehensive clinical molecular screening of BRAF-negative pediatric low-grade gliomas, to reveal rare fusions serving as targets for precision therapy.
30.	Deland, Lily, et al. (författare) Novel TPR::ROS1 Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma. 2022 Ingår i: Cancer genomics & proteomics. - : Anticancer Research USA Inc.. - 1109-6535 .- 1790-6245. ; 19:6, s. 711-726 Tidskriftsartikel (refereegranskat)abstract Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumors.Here, we present a 16-month-old boy, with a brain tumor in the third ventricle. The patient underwent complete resection but relapsed two years after diagnosis and underwent a second operation. The tumor was initially classified as a low-grade glioma (WHO grade 2); however, methylation profiling suggested the newly WHO-recognized type: infant-type hemispheric glioma. To further refine the molecular background, and search for druggable targets, whole genome (WGS) and whole transcriptome (RNA-Seq) sequencing was performed.Concomitant WGS and RNA-Seq analysis revealed several segmental gains and losses resulting in complex structural rearrangements and fusion genes. Among the top-candidates was a novel TPR::ROS1 fusion, for which only the 3' end of ROS1 was expressed in tumor tissue, indicating that wild type ROS1 is not normally expressed in the tissue of origin. Functional analysis by Western blot on protein lysates from transiently transfected HEK293 cells showed the TPR::ROS1 fusion gene to activate the MAPK-, PI3K- and JAK/STAT- pathways through increased phosphorylation of ERK, AKT, STAT and S6. The downstream pathway activation was also confirmed by immunohistochemistry on tumor tissue slides from the patient.We have mapped the activated oncogenic pathways of a novel ROS1-fusion gene and broadened the knowledge of the newly recognized infant-type glioma subtype. The finding facilitates suitable targeted therapies for the patient in case of relapse.
31.	Dänhardt, Juliana, et al. (författare) Ekosystemtjänster i det skånska jordbrukslandskapet 2013 Rapport (populärvet., debatt m.m.)abstract Jordbrukslandskapet tillhandahåller ekosystemtjänster som utgör förutsättningen för en uthållig jordbruksproduktion och är till nytta för samhället i stort. Bakom dessa finns ekologiska processer som beror av samspel mellan en mångfald av organismer. Skånes jordbruk har genomgått betydande förändringar som förändrat landskapet och livsmiljön för många av dessa. För att bevara och förvalta ekosystemtjänsterna krävs en förståelse för sambanden mellan jordbruk, landskap och ekosystemprocesser. Rapporten beskriver ekologiska processer som ligger till grund för några viktiga ekosystemtjänster i Skånes jordbrukslandskap och visar betydelsen av biologisk mångfald för deras funktion. Där så är möjligt beskrivs hur de kan värderas. Slutligen redovisas praktiska åtgärder som gynnar dem. Rapporten visar att ekosystemtjänster inte enkelt går att ersätta med teknologiska lösningar, utan att förvaltning av dessa tjänster lönar sig. Detta kräver ökad ekologisk kunskap och anpassade styrmedel vilket kräver ökat samråd och regelbunden återkoppling mellan lantbrukare, myndigheter och forskare. Förhoppningen är att rapporten, framtagen av Lunds universitet och Region Skåne, inspirerar till detta!
32.	Ejhed, Heléne, et al. (författare) Näringsbelastningen på Östersjön och Västerhavet 2014 : Sveriges underlag till Helcoms sjätte Pollution Load Compilation 2016 Rapport (övrigt vetenskapligt/konstnärligt)abstract Denna rapport presenterar den senaste mest detaljerade och tillförlitliga bedömningen av närsaltsbelastning från svenska källor som hittills genomförts. Denna rapport, tillsammans med underlagsrapporter, redovisar resultat, underlagsdata, och beräkningsmetoder på detaljnivå för att uppnå transparens och spårbarhet samt för att möjliggöra vidareanvändning i arbetet inom svensk vattenförvaltning.Havs- och vattenmyndigheten har gett SMED1 i uppdrag att genomföra beräkningar av källor till kväve- och fosforbelastning avseende år 2014 på sjöar, vattendrag och havet för hela Sverige. Syftet var att ge underlag till Sveriges rapportering till Helcom ”Pollution Load Compilation 6 - PLC6” samt till vattenförvaltningens arbete i Sverige. Liknande beräkningar har genomförts tidigare men aldrig med så hög upplösning i flera av underlagen. Arbetet innebär att stora mängder data har bearbetats och beräknats för att ge heltäckande information för hela Sverige fördelat på cirka 23 000 vattenförekomstområden. Den ökade upplösningen, tillsammans med bättre kvalitet på indata och nyutvecklade beräkningsrutiner ger bättre tillförlitlighet i resultaten av total belastning även på lokal nivå. Utvecklingen som genomförts kommer att ligga till grund för nästa belastningsrapportering, PLC 7, samt den fördjupade uppföljningen av miljökvalitetsmålet Ingen övergödning (FUT) och framtida arbeten inom havs- och vattenförvaltningen.De nya beräkningarna bygger på nya högupplösta markanvändnings- och jordartskartor, nya underlag avseende rening i små avloppsanläggningar och dagvatten samt en ny höjddatabas (2 meters upplösning). Höjddatabasen har använts för beräkning av markens lutning, vilket har stor betydelse för fosforläckaget. Nya mätningar i skogsområden i sydvästra Sverige har lett till en bättre beskrivning av skogsmarkens läckage och att en ny modell för beräkning av näringsämnesretentionen har tagits fram. Dessa förfinade indata och förbättrade beräkningsverktyg gör att resultaten är säkrare även på lokal skala eller för enskilda vattenförekomster.Resultaten är tillgängliga för alla via webbverktyget Tekniskt Beräkningssystem Vatten (TBV, tbv.smhi.se). Resultaten presenteras som brutto- samt nettobelastning. Bruttobelastning är den mängd näringsämnen som släpps ut vid källan till ett vattendrag eller sjö från till exempel ett avloppsreningsverk eller ett jordbruksfält. Nettobelastning är den del av bruttobelastningen som når havet. Dessutom presenteras resultat som antropogen- och totalbelastning. Antropogen belastning kommer från mänskliga aktiviteter, såsom odling av jordbruksmark eller industriutsläpp. Totalbelastning är summan av antropogen belastning och bakgrundsbelastning, den naturliga belastning som skulle ske oberoende av människan. Avgränsningen mellan vad som är bakgrundsbelastning och antropogen belastning har baserats på Helcoms definition och all markanvändning bidrar med en naturlig belastning samt eventuell antropogen belastning. Till exempel anses belastning från mark bevuxen med skog helt vara bakgrund, medan belastningen från hygge och jordbruksmark anses vara en summa av bakgrund och antropogen belastning. I resultat där antropogen belastning presenteras, så har bakgrundsbelastningen tagits bort.Jordbruks- and skogsmark är de två största källorna till den totala belastningen på havet för både kväve och fosfor, med 34 100 respektive 34 900 ton kväve, samt 1 130 resp. 850 ton fosfor år 2014. Tillsammans står dessa källor för cirka 60 % av den totala belastningen. Av den antropogena belastningen står jordbruket för den största andelen (23 300 ton samt 460 ton fosfor), följt av utsläpp från avloppsreningsverk (14 000 ton kväve samt 240 ton fosfor). Belastningen från skogsmark ingår enbart i bakgrund och den antropogena belastningen från hyggen bidrar endast med 1500 ton kväve och 20 ton fosfor Bottenhavet, Egentliga Östersjön och Kattegatt är de bassänger som tar emot mest kväve av Sveriges totala belastning på havet (29 500 ton, 29 400 ton respektive 28 700 ton, vilket motsvarar cirka 25 % vardera). I Bottenhavet är dock en stor del av belastningen naturlig bakgrundsbelastning. Egentliga Östersjön och Kattegatt tar emot mest av Sveriges antropogena belastning, 33 % respektive 31 %. I jämförelse mellan vilka havsbassänger som är mest belastade av fosfor, så är det Bottenhavet som tar emot mest (990 ton eller 30 % av den totala belastningen). Strax under en fjärdedel av Sveriges totala belastning på havet, belastar Egentliga Östersjön (780 ton) och omkring en femtedel belastar Kattegatt och Bottenviken (680 respektive 630 ton). Aktionsplanen för Östersjön (Baltic Sea Action Plan, BSAP) anger utsläppsmål, med syfte att nå God miljöstatus i Östersjön och Kattegatt. För fosfor är målet uppnått i alla bassänger utom Egentliga Östersjön, där det är ett utmanande mål och det kommer att bli mycket svårt att minska fosforbelastningen under belastningstaket (308 ton). Det krävs omfattande åtgärder av de antropogena källorna, och dessutom utgör bakgrundsbelastningen en betydande del av den totala belastningen. Total nettobelastning av fosfor till Egentliga Östersjön är 780 ton enligt dessa beräkningar, varav 370 ton är beräknat som bakgrundsbelastning. Det innebär att åtgärder måste minska även bakgrundsbelastningen, t.ex. genom skapande av våtmarker. För att Egentliga Östersjön ska kunna uppnå god miljöstatus med avseende på övergödning kommer det även att behövas åtgärder i Östersjöns andra delbassänger.På grund av stora skillnader i metoder och indata, är det inte möjligt att direkt jämföra hur belastningen har ändrats sedan PLC 5 och den fördjupade uppföljningen av miljökvalitetsmålet Ingen övergödning. Som exempel har arealen jordbruksmark minskat med omkring 1900 km2 sedan tidigare sammanställningar, och det har lett till minskat näringsämnesläckage. Storleksordningen på denna minskning kan i nuläget inte utläsas från beräkningarna eftersom de är gjorda med förfinad underlagsinformation jämfört med tidigare år. Faktum är att vid en direkt jämförelse mellan belastning år 2006 (PLC5) och år 2011 (FUT) så är den totala fosforbelastningen från jordbruksmarken högre år 2014 (PLC6) jämfört med Havs- och vattenmyndighetens rapport 2016:12 10 tidigare. Samtidigt visar de nya beräkningarna på att den antropogena delen är lägre än vad som tidigare beräknats. Det krävs omräkningar av gamla PLCdata med den nya metoden för att få klarhet i hur mycket av dessa ändringar som beror på åtgärder inom jordbruket och hur mycket som är på grund av förfinade indata och förbättrade metoder. Belastningen från punktkällorna beräknas på samma sätt som förr och där är det tydligt att utsläppen till havet har minskat. I PLC6 (år 2014) stod avloppsreningsverk för 240 ton fosfor samt 14 000 ton kväve, medan i PLC5 (2006) var belastningen 350 ton fosfor- samt 17 000 ton kvävebelastning (netto). Industrier har också minskat sin belastning på havet och svarar nu för 250 ton fosfor samt 3 800 ton kväve, jämfört med 320 fosfor och 4 800 ton kväve år 2006.
33.	Ek, Helene, 1976, et al. (författare) Effects of TNT leakage from dumped ammunition on fish and invertebrates in static brackish water systems 2008 Ingår i: Ecotoxicology and Environmental Safety. ; 69:1, s. 104-111 Tidskriftsartikel (refereegranskat)abstract The objective of the present study was to study the release and effect of TNT from dumped ammunition. Cleaved artillery shells were placed in static brackish water systems for 5 months, and another 12 months with 5 cm sediment burial. The toxicity was determined in bioassays with crustaceans (Nitocra spinipes and Hyalella azteca) and/or European flounder (Platichtys flesus). The water phase was analysed for TNT using colorimetric method and GC-MS. This study showed a rapid release of TNT to acutely toxic concentrations when the cleaved ammuniton was not covered with sediment under static conditions, but that the release was effectively inhibited by sediment burial of the artillery shells. Hence, at least in a short-term perspective, acute adverse effects of sediment-buried ammunition on aquatic organisms should be greatly reduced.
34.	Ek, Helene, 1976, et al. (författare) Fate and effects of 2,4,6-trinitrotoluene (TNT) from dumped ammunition in a field study with fish and invertebrates 2006 Ingår i: Archives of Environmental Contamination and Toxicology. - : Springer Science and Business Media LLC. - 0090-4341 .- 1432-0703. ; 51:2, s. 244-252 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract 2,4,6-Trinitrotoluene (TNT) is the major explosive ingredient in ammunition dumped into lakes and sea after World War II. The aim of the present field study was to study the fate and effect of TNT and its degradation products from dumped ammunition. Artillery shells were cleaved longitudinally to expose TNT and placed in open boxes filled with sediment, and then placed at the sea bottom. Sediment samples were taken in each box at the start and after 3, 9, 13, 20, 24, 33, and 36 months, and the sediments were tested for toxicity with bioassays using Nitocra spinipes (96 h), Hyalella azteca (96 h), and Daphnia magna (24 and 48 h). The result from the bioassays showed no impact of dumped ammunition on the survival of H. azteca and mobility of D. magna. Bioassays with N. spinipes showed significant differences in toxicity between control boxes and boxes with shells after 9 months and thereafter. The mean mortality (+/- SD) of N. spinipes in boxes with shells was 63 +/- 22%, and the mortality in control boxes was 23 +/- 17%. No continuous increase in sediment toxicity over time was found. After 3 years, cages with European flounder (Platichtys flesus) and blue mussels (Mytilus edulis) were attached to the boxes. The fish were examined for biochemical and physiological effects 8 weeks later. Exposure to ammunition, which had rested on the sea bottom 3 years, caused no significant effects on body indices, hematological variables, and detoxification and antioxidant enzymes activities in the flounder. The sediment, bile, and blood plasma of exposed fish, and hepatopancreas of exposed mussels, contained no detectable levels of TNT and its metabolites. Only minor disappearance of TNT from the shells could be detected by visual inspection on site (by scuba divers). This study suggests that the survival of sensitive benthic organisms, e.g., N. spinipes, might be negatively affected at an ammunition dumping site.
35.	Ek, Helene, 1976, et al. (författare) TNT leakage through sediment to water and toxicity to Nitocra spinipes 2007 Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier BV. - 0147-6513. ; 67:3, s. 341-348 Tidskriftsartikel (refereegranskat)abstract The fate and effects of 2,4,6-trinitrotoluene (TNT) at marine ammunition dumping sites are essentially unknown. The objective of this study was to examine the release from solid TNT to seawater when covered by sediment of two different types (sandy and fine-grained) and thickness (0, 1, 2, and 4 cm), under different temperatures (5, 10, and 20 °C), and light conditions (ambient daylight and darkness) in the laboratory. The water column was analysed for TNT and some of its common transformation products, and toxicity to the copepod Nitocra spinipes after 1, 2, 4, 8, 19, and 32 weeks. Leakage of TNT to seawater and the toxicity to N. spinipes was significantly reduced by sediment burial, especially in fine-grained sediment. Hence, this study suggests that adverse effects of TNT in dumped ammunition on aquatic organisms should be delayed/reduced at low temperature and when TNT is covered sediment, especially with fine-grained sediment.
36.	Elenkov, Angel, et al. (författare) Male childlessness as independent predictor of risk of cardiovascular and all-cause mortality : A population-based cohort study with more than 30 years follow-up 2020 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15 Tidskriftsartikel (refereegranskat)abstract In a recent population-based study, an elevated risk of the Metabolic syndrome (MetS) and type 2 diabetes was found in childless men compared to those who have fathered one or more children. Therefore, by using a larger cohort of more than 22 000 men from the Malmo Preventive Project (MPP) we aimed to expand our observations in order to evaluate the metabolic profile of childless men and to evaluate if childlessness is an additional and independent predictor of major adverse cardiovascular events (MACE), mortality and incident diabetes when accounting for well-known biochemical, anthropometric, socio-economic and lifestyle related known risk factors. Logistic regression was used to assess risk of MACE, diabetes and MetS at baseline. Multivariate Cox regression was used to evaluate the risks of MACE and mortality following the men from baseline screening until first episode of MACE, death from other causes, emigration, or end of follow-up (31st December 2016) adjusting for age, family history, marital status, smoking, alcohol consumption, educational status, body mass index, prevalent diabetes, high blood lipids, increased fasting glucose and hypertension. Childless men presented with a worse metabolic profile than fathers at the baseline examination, with elevated risk of high triglycerides, odds ratio (OR) 1.24 (95% CI: 1.10–1.42), high fasting glucose OR 1.23 (95%CI: 1.05–1.43) and high blood pressure, OR 1.28 (95%CI: 1.14–1.45), respectively. In the fully adjusted prospective analysis, childless men presented with elevated risk of cardiovascular mortality, HR: 1.33 (95% CI: 1.18–1.49) and all-cause mortality, HR 1.23 (95%CI: 1.14–1.33), respectively. In conclusion, these results add to previous studies showing associations between male reproductive health, morbidity and mortality. Male childlessness, independently of well-known socio-economic, behavioral and metabolic risk factors, predicts risk of cardiovascular disease and mortality. Consequently, this group of men should be considered as target population for preventive measures.
37.	Enevold, Jessica, et al. (författare) Datorspel som pedagogisk resurs 2012 Ingår i: Ett trollspö på katedern : att arbeta med Fantasy i skolan - att arbeta med Fantasy i skolan. - 9789170187377 Bokkapitel (populärvet., debatt m.m.)abstract Fantasy är en tvärmedial genre. Det innebär att det som är typiskt för fantasy-genren och dess ”outworldliness” (Mackay 2001), det vill säga karaktärer med magiska krafter, talande djur, andar och älvor, geografiskt hisnande sagovärldar inspirerade av historiska och litterära myter och legender – inte bara återfinns i böcker utan även i film, brädspel, LAJV/LARP (rollspel med kostymer där du själv spelar en karaktär) konst och datorspel. I denna bok om fantasy som alternativt material i utbildning, handlar mitt bidrag om just datorspelens möjlighet att utgöra pedagogisk resurs. Jag utgår från flera discipliners perspektiv på datorspel som har det gemensamt att de ingår i en växande spelforskningstradition som vanligtvis betecknas på engelska, Game Studies, men som även ingår i den större kategorin Games Research, dvs spelforskning. I vad som följer redogör jag kortfattat för hur spel förstås inom denna tradition med ett flertal exempel från pågående forskning, och ger ett antal råd om vad en lärare som vill använda sig av datorspel som pedagogisk resurs bör och kan ha i åtanke och några lästips och analysexempel från forskningen som förhoppningsvis kan tjäna som inspiration för att arbeta med datorspel i skolan.
38.	Erfurth, Eva Marie, et al. (författare) Is growth hormone deficiency contributing to heart failure in patients with beta-thalassemia major? 2004 Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 1479-683X .- 0804-4643. ; 151:2, s. 161-166 Tidskriftsartikel (refereegranskat)abstract A 21-year-old woman with beta-thalassemia major (beta-TM) and GH deficiency developed end-stage heart failure, New York Heart Association (NYHA) functional class IV, within 3 months after withdrawal of recombinant human growth hormone (GH). A myocardial biopsy excluded myocarditis and showed moderate iron deposit in the heart. Before her admission, intensified treatments with digoxin, angiotensin-converting enzyme inhibitor, diuretics and extra chelation therapy (desferrioxamine (DFO)) had not improved her progressive heart failure. At admission, GH was reinstituted together with intensified treatment of cardiac drugs and low doses of DFO, and her heart failure reversed. Four months later, NYHA functional class II was reached and within 1 year her cardiac function was normalised. We suggest that GH deficiency due to iron-induced damage to the hypothalamic-pituitary axis can contribute to heart failure in adult patients with beta-TM.
39.	Escobar, Karla, et al. (författare) Multi-level governance and civil society’s work on integrating migrants after the migrant crisis of 2015 in Jönköping 2021 Rapport (övrigt vetenskapligt/konstnärligt)abstract From foreword: This report describes how civil society and the public sector in Jönköping municipality collaborated with each other in assisting the welcoming and integration of the refugees who arrived in the municipality during the so-called ‘migrant crisis’ of 2015.
40.	Escobar, Karla, et al. (författare) Styrda fast ändå inte? : Flernivåstyrning och civilsamhällets arbete med att integrera flyktingar efter flyktingkrisen 2015 i Jönköping 2021 Rapport (övrigt vetenskapligt/konstnärligt)abstract Från förordet: Den här rapporten handlar om hur civilsamhället och offentlig sektor i Jönköpings kommun har samarbetat för att hjälpa till att välkomna och integrera alla de flyktingar som kom i samband med flyktingkrisen 2015. Rapporten är en del av en större studie som i förlängningen syftar till att jämföra civilsamhällets roll i mottagningssystemen i Kanada och Sverige och är finansierad av Social Sciences and Humanities Research Council i Kanada.
41.	Friberg, Andrew S, et al. (författare) Transplantable functional islet mass – predictive biomarkers of graft function in islet after kidney transplanted patients Annan publikation (övrigt vetenskapligt/konstnärligt)abstract The ability to predict clinical function of a specific islet batch released for clinical transplantation using standardized variables remains an elusive goal. Analysis of donor, islet isolation, quality control and recipient variables was undertaken in 110 islet after kidney (IAK) transplants and correlated to the pre- to 28-day posttransplant change in C-peptide to glucose and creatinine ratio (ΔCP/GCr). Using backward multiple regression the variables positively associated to ΔCP/GCr were islet volume transplanted (p<0.001) and glucose stimulated insulin secretion (SI) (p=0.009). Factors negatively associated to ΔCP/GCr were cold ischemia time (CIT) (p=0.002) and total tissue volume (p=0.009). Donor age, donor body mass index, number of retrieved organs from the donor, preservation solution, islet insulin content, body weight of the recipient of the islets had no influence on transplant function. The transplantable functional islet mass (TFIM), accounting for islet volume transplanted, SI, CIT, and total tissue volume explained 39% of the variance of the clinical outcome in the IAK data set. Therefore, the TFIM provides a straightforward and potent tool to guide the decision to utilize a specific islet preparation for clinical transplantation.
42.	Friberg, Andrew S., et al. (författare) Transplanted functional islet mass : donor islet preparation, and recipitent factors influence early graft function in islet-after-kidney patients 2012 Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 93:6, s. 632-638 Tidskriftsartikel (refereegranskat)abstract Background.The ability to predict clinical function of a specific islet batch released for clinical transplantation using standardized variables remains an elusive goal.Methods. Analysis of 10 donor, 7 islet isolation, 3 quality control, and 6 recipient variables was undertaken in 110 islet-after-kidney transplants and correlated to the pre- to 28-day posttransplant change in C-peptide to glucose and creatinine ratio ([DELTA]CP/GCr).Results.Univariate analysis yielded islet volume transplanted (Spearman r=0.360, P<0.001) and increment of insulin secretion (r=0.377, P<0.001) as variables positively associated to [DELTA]CP/GCr. A negative association to [DELTA]CP/GCr was cold ischemia time (r=-0.330, P<0.001). A linear, backward-selection multiple regression was used to obtain a model for the transplanted functional islet mass (TFIM). The TFIM model, composed of islet volume transplanted, increment of insulin secretion, cold ischemia time, and exocrine tissue volume transplanted, accounted for 43% of the variance of the clinical outcome in the islet-after-kidney data set.Conclusion.The TFIM provides a straightforward and potent tool to guide the decision to use a specific islet preparation for clinical transplantation.
43.	Friberg, Fredrik Femtehjell, et al. (författare) When disaster strikes: staff recall and the use of staff recall systems during mass patient influx at Norwegian emergency primary health care centers - a cross-sectional study 2023 Ingår i: BMC Emergency Medicine. - : BMC. - 1471-227X. ; 23:1 Tidskriftsartikel (refereegranskat)abstract BackgroundIn Norway, planning for disasters has been specifically emphasized since the incidents on July 22(nd,) 2011. Every municipality is now legislated to have a contingency plan that includes plans for staff recall during situations with mass influx of patients. Whether the primary health care services in Norway are prepared for mass influx of patients remains unclear.Aims of the studyThe aims of this study were (1) to assess the experiences of head doctors at emergency primary health care centers (EPHCC) in Norway with mass influx of patients, (2) to explore mass influx and staff recall procedures in use, (3) to assess head doctors experiences with staff recall systems, and (4) to assess their perspective on automatized staff recall systems. We also wanted to assess whether there were differences between small and large EPHCCs regarding whether they had plans in place.MethodsThe study had a cross-sectional, multicenter design, using a self-developed questionnaire. The questionnaire was developed utilizing recommendations from the Delphi technique, including an expert group and piloting. A purposive sampling strategy was used, including head doctors from Norwegian EPHCCs (n = 169). Data were analyzed using the Statistical Package for the Social Sciences, and included descriptive statistics, Chi-Square tests and Shapiro-Wilks. Free-text answers were analyzed by content analysis.ResultsA total of 64 head doctors responded to the questionnaire. The results show that 25% of the head doctors had experienced mass influx of patients at their EPHCC. In total 54.7% of Norwegian EPHCCs did not have disaster plans that consider mass influx situations. The majority of EPHCCs plan to recall staff one by one (60.3%) or through Short-Message-Systems (34.4%). Most EPHCCs had available telephone "alarm" lists (81.4%), that are updated regularly (60.9%). However, only 17.2% had plans that consider loss of mobile phone connection or internet. In total, 67,2% of the head doctors reported to have little experience with automatized staff recall systems, and 59,7% reported to have little knowledge about such systems. There were no significant difference between small and large EPHCCs in having plans or not.ConclusionEven though our results show that few EPHCCs experience mass influx of patients, it is important to be prepared when such incidents do occur. Our results indicate that it is still potential for improvement regarding plans for staff recall and implementation of staff recall systems at Norwegian EPHCCs. Involving national disaster medicine experts in the process of generating tools or checklists could aid when constructing disaster plans. Education and implementation of training for mass influx situations at all levels should always be highlighted.
44.	Gantelius, Jesper, et al. (författare) A Lateral Flow Protein Microarray for Rapid and Sensitive Antibody Assays 2011 Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 12:11, s. 7748-7759 Tidskriftsartikel (refereegranskat)abstract Protein microarrays are useful tools for highly multiplexed determination of presence or levels of clinically relevant biomarkers in human tissues and biofluids. However, such tools have thus far been restricted to laboratory environments. Here, we present a novel 384-plexed easy to use lateral flow protein microarray device capable of sensitive (<30 ng/mL) determination of antigen-specific antibodies in ten minutes of total assay time. Results were developed with gold nanobeads and could be recorded by a cell-phone camera or table top scanner. Excellent accuracy with an area under curve (AUC of 98% was achieved in comparison with an established glass microarray assay for 26 antigen-specific antibodies. We propose that the presented framework could find use in convenient and cost-efficient quality control of antibody production, as well as in providing a platform for multiplexed affinity-based assays in low-resource or mobile settings.
45.	Gantelius, Jesper, et al. (författare) A ten-minute high density lateral flow protein microarray assay 2011 Ingår i: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011. - 9781618395955 ; , s. 1176-1178 Konferensbidrag (refereegranskat)abstract Protein microarrays are useful tools for highly multiplexed determination of presence or levels of clinically relevant biomarkers in human tissues and biofluids. However, such tools have thus far been restricted to laboratory environments. Here, we present a novel 384-plexed easy to use lateral flow protein microarray device capable of sensitive (<50ng/ml) determination of antigen specific antibodies in less than ten minutes total assay time. Results were developed with gold nanobeads and could be recorded by a cell-phone camera or table top scanner. Excellent accuracy (AUC=99.4%) was achieved in comparison with an established glass microarray assay for 26 antigen-specific antibodies.
46.	Gard, Anna, et al. (författare) Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging 2024 Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert Inc.. - 0897-7151 .- 1557-9042. Tidskriftsartikel (refereegranskat)abstract Sports-related concussions may cause white matter injuries and persistent post-concussive symptoms (PPCS). We hypothesized that athletes with PPCS would have neurocognitive impairments and white matter abnormalities that could be revealed by advanced neuroimaging using ultra-high field strength diffusion tensor (DTI) and diffusion kurtosis (DKI) imaging metrics and cerebrospinal fluid (CSF) biomarkers. A cohort of athletes with PPCS severity limiting the ability to work/study and participate in sport school and/or social activities for ≥6 months completed 7T magnetic resonance imaging (MRI) (morphological T1-weighed volumetry, DTI and DKI), extensive neuropsychological testing, symptom rating, and CSF biomarker sampling. Twenty-two athletes with PPCS and 22 controls were included. Concussed athletes performed below norms and significantly lower than controls on all but one of the psychometric neuropsychology tests. Supratentorial white and gray matter, as well as hippocampal volumes did not differ between concussed athletes and controls. However, of the 72 examined white matter tracts, 16% of DTI and 35% of DKI metrics (in total 28%) were significantly different between concussed athletes and controls. DKI fractional anisotropy and axial kurtosis were increased, and DKI radial diffusivity and radial kurtosis decreased in concussed athletes when compared with controls. CSF neurofilament light (NfL; an axonal injury marker), although not glial fibrillary acidic protein, correlated with several diffusion metrics. In this first 7T DTI and DKI study investigating PPCS, widespread microstructural alterations were observed in the white matter, correlating with CSF markers of axonal injury. More white matter changes were observed using DKI than using DTI. These white matter alterations may indicate persistent pathophysiological processes following concussion in sport.
47.	Gard, Gunvor, et al. (författare) Need for structured healthcare organization and support for return to work after stroke in Sweden : Experiences of stroke survivors 2019 Ingår i: Journal of Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1651-2081 .- 1650-1977. ; 51:10, s. 741-748 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: To explore stroke survivors' experiences of healthcare-related facilitators and barriers concerning return to work after stroke. DESIGN: A qualitative study. SETTING: Outpatient stroke rehabilitation unit at a University Hospital in southern Sweden. PARTICIPANTS: A convenient sample of 20 persons admitted to Skåne University Hospital for acute stroke care (median age 52 years), in employment of at least 10 h per week at stroke onset and having been referred to stroke rehabilitation within 180 days. METHODS: The interviews were performed by focus groups, and the data were analysed by content analysis. RESULTS: Facilitating factors were a tailored rehabilitation content with relevant treatments, adequate timing and a structured stepwise return-to-work process. A lack of sufficient early healthcare information, rehabilitation planning and coordination were perceived as barriers. An early rehabilitation plan, a contact person, and improved communication between rehabilitation actors were requested, as well as help with work transport, home care, children and psychosocial support for families. CONCLUSION: Tailored rehabilitation content and a structured stepwise return-to-work process facilitated return to work. Insufficient structure within the healthcare system and lack of support in daily life were perceived barriers to return to work, and need to be improved. These aspects should be considered in the return-to-work process after stroke.
48.	Gaudenzi, Giulia, et al. (författare) Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda) : Observational Cohort Study Protocol of the "PI-POC" Trial 2020 Ingår i: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 22:11 Tidskriftsartikel (refereegranskat)abstract Background: A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, manage patients, and improve clinical outcome. Objective: The Pediatric Infection-Point-of-Care (PI-POC) trial is investigating novel methods to improve and strengthen the differential diagnostics of suspected childhood CNS infections in low-income health systems such as those in Southwestern Uganda. This will be achieved by evaluating (1) a novel DNA-based diagnostic assay for CNS infections, (2) a commercially available multiplex PCR-based meningitis/encephalitis (ME) panel for clinical use in a facility-limited laboratory setting, (3) proteomics profiling of blood from children with severe CNS infection as compared to outpatient controls with fever yet not severely ill, and (4) Myxovirus resistance protein A (MxA) as a biomarker in blood for viral CNS infection. Further changes in the etiology of childhood CNS infections after the introduction of the pneumococcal conjugate vaccine against Streptococcus pneumoniae will be investigated. In addition, the carriage and invasive rate of Neisseria meningitidis will be recorded and serotyped, and the expression of its major virulence factor (polysaccharide capsule) will be investigated. Methods: The PI-POC trial is a prospective observational study of children including newborns up to 12 years of age with clinical features of CNS infection, and age-/sex-matched outpatient controls with fever yet not severely ill. Participants are recruited at 2 Pediatric clinics in Mbarara, Uganda. Cerebrospinal fluid (for cases only), blood, and nasopharyngeal (NP) swabs (for both cases and controls) sampled at both clinics are analyzed at the Epicentre Research Laboratory through gold-standard methods for CNS infection diagnosis (microscopy, biochemistry, and culture) and a commercially available ME panel for multiplex PCR analyses of the cerebrospinal fluid. An additional blood sample from cases is collected on day 3 after admission. After initial clinical analyses in Mbarara, samples will be transported to Stockholm, Sweden for (1) validation analyses of a novel nucleic acid-based POC test, (2) biomarker research, and (3) serotyping and molecular characterization of S. pneumoniae and N. meningitidis. Results: A pilot study was performed from January to April 2019. The PI-POC trial enrollment of patients begun in April 2019 and will continue until September 2020, to include up to 300 cases and controls. Preliminary results from the PI-POC study are expected by the end of 2020. Conclusions: The findings from the PI-POC study can potentially facilitate rapid etiological diagnosis of CNS infections in low-resource settings and allow for novel methods for determination of the severity of CNS infection in such environment.
49.	Gryth, Dan, et al. (författare) Evaluation of medical command and control using performance indicators in a full-scale, major aircraft accident exercise. 2010 Ingår i: Prehospital and Disaster Medicine. - : Cambridge University Press. - 1049-023X .- 1945-1938. ; 25:2, s. 118-123 Tidskriftsartikel (refereegranskat)abstract INTRODUCTION: Large, functional, disaster exercises are expensive to plan and execute, and often are difficult to evaluate objectively. Command and control in disaster medicine organizations can benefit from objective results from disaster exercises to identify areas that must be improved.OBJECTIVE: The objective of this pilot study was to examine if it is possible to use performance indicators for documentation and evaluation of medical command and control in a full-scale major incident exercise at two levels: (1) local level (scene of the incident and hospital); and (2) strategic level of command and control. Staff procedure skills also were evaluated.METHODS: Trained observers were placed in each of the three command and control locations. These observers recorded and scored the performance of command and control using templates of performance indicators. The observers scored the level of performance by awarding 2, 1, or 0 points according to the template and evaluated content and timing of decisions. Results from 11 performance indicators were recorded at each template and scores greater than 11 were considered as acceptable.RESULTS: Prehospital command and control had the lowest score. This also was expressed by problems at the scene of the incident. The scores in management and staff skills were at the strategic level 15 and 17, respectively; and at the hospital level, 17 and 21, respectively.CONCLUSIONS: It is possible to use performance indicators in a full-scale, major incident exercise for evaluation of medical command and control. The results could be used to compare similar exercises and evaluate real incidents in the future.
50.	Gustafsson Nyckel, Jan, 1960-, et al. (författare) Travelling and Recontextualization of Discourses on Quality in Early Childhood Education and Care : A Meta-Ethnographic Investigation 2023 Ingår i: Oxford Ethnography and Education Conference 2023. ; , s. 1-1 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract This article is a response to the need for comparative and critical studies of preschool as a local practice and examines the recontextualization of quality in Early childhood education and care. The aim of this meta-ethnographic study is to investigate how neoliberal policy discourses on quality are recontextualized and embedded in local early childhood and care institutional practices. A central concept in the analysis is recontextualization, and our pre-understanding of how neoliberal policy discourses are travelling and transformed from official to local policy that is embedded in the preschools’ work with quality as an institutional practice.The findings show how neoliberal policy discourses on quality is recontextualized, transformed and embedded in local institutional practices with different results and responses. The analysis uncovers three strategic, institutional responses as Enacting through acquiescence response, Defiance response as resistance and obfuscation of class, gender, and post-colonial perspective.

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