| 1. |
- Tomic, Tajana Tesan, et al.
(författare)
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MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression
- 2020
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Ingår i: PLOS Genetics. - : Public Library of Science. - 1553-7390 .- 1553-7404. ; 16:6
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Tidskriftsartikel (refereegranskat)abstract
- Identification of additional cancer-associated genes and secondary mutations driving the metastatic progression in pheochromocytoma and paraganglioma (PPGL) is important for subtyping, and may provide optimization of therapeutic regimens. We recently reported novel recurrent nonsynonymous mutations in the MYO5B gene in metastatic PPGL. Here, we explored the functional impact of these MYO5B mutations, and analyzed MYO5B expression in primary PPGL tumor cases in relation to mutation status. Immunohistochemistry and mRNA expression analysis in 30 PPGL tumors revealed an increased MYO5B expression in metastatic compared to non-metastatic cases. In addition, subcellular localization of MYO5B protein was altered from cytoplasmic to membranous in some metastatic tumors, and the strongest and most abnormal expression pattern was observed in a paraganglioma harboring a somatic MYO5B:p.G1611S mutation. In addition to five previously discovered MYO5B mutations, the present study of 30 PPGL (8 previous and 22 new samples) also revealed two, and hence recurrent, mutations in the gene paralog MYO5A. The three MYO5B missense mutations with the highest prediction scores (p.L587P, p.G1611S and p.R1641C) were selected and functionally validated using site directed mutagenesis and stable transfection into human neuroblastoma cells (SK-N-AS) and embryonic kidney cells (HEK293). In vitro analysis showed a significant increased proliferation rate in all three MYO5B mutated clones. The two somatically derived mutations, p.L587P and p.G1611S, were also found to increase the migration rate. Expression analysis of MYO5B mutants compared to wild type clones, demonstrated a significant enrichment of genes involved in migration, proliferation, cell adhesion, glucose metabolism, and cellular homeostasis. Our study validates the functional role of novel MYO5B mutations in proliferation and migration, and suggest the MYO5-pathway to be involved in the malignant progression in some PPGL tumors. © 2020 Tomic et al.
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| 2. |
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| 3. |
- Aydogdu, Canan, 1978, et al.
(författare)
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Radar Interference Mitigation for Automated Driving : Exploring Proactive Strategies
- 2020
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Ingår i: IEEE signal processing magazine (Print). - Piscataway : Institute of Electrical and Electronics Engineers (IEEE). - 1053-5888 .- 1558-0792. ; 37:4, s. 72-84
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Tidskriftsartikel (refereegranskat)abstract
- Autonomous driving relies on a variety of sensors, especially radars, which have unique robustness under heavy rain/fog/snow and poor light conditions. With the rapid increase of the amount of radars used on modern vehicles, where most radars operate in the same frequency band, the risk of radar interference becomes a compelling issue. This article analyzes automotive radar interference and proposes several new approaches that combine industrial and academic expertise toward the goal of achieving interference-free autonomous driving (AD). © IEEE.
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| 4. |
- Aydogdu, Canan, 1978, et al.
(författare)
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Radar Interference Mitigation through Active Coordination
- 2021
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Ingår i: IEEE National Radar Conference - Proceedings. - : IEEE. - 1097-5659. ; 2021-May, s. 1-6
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Konferensbidrag (refereegranskat)abstract
- Intelligent transportation is heavily reliant on radar, which have unique robustness under heavy rain/fog/snow and poor light conditions. With the rapid increase of the number of radars used on modern vehicles, most operating in the same frequency band, the risk of radar interference becomes an important issue. As in radio communication, interference can be mitigated through coordination. We present and evaluate two approaches for radar interference coordination, one for FMCW and one for OFDM, and highlight their challenges and opportunities.
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| 5. |
- Carvajal, Gisela, 1983, et al.
(författare)
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Comparison of Automotive FMCW and OFDM Radar Under Interference
- 2020
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Ingår i: IEEE National Radar Conference - Proceedings. - New York, NY : IEEE. - 1097-5659. ; 2020-September
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Konferensbidrag (refereegranskat)abstract
- Automotive radars are subject to interference in spectrally congested environments. To mitigate this interference, various waveforms have been proposed. We compare two waveforms (FMCW and OFDM) in terms of their radar performance and robustness to interference, under similar parameter settings. Our results indicate that under proper windowing both waveforms can achieve similar performance, but OFDM is more sensitive to interference.
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| 6. |
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| 7. |
- Boström, Pontus, 1982, et al.
(författare)
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SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.
- 2007
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Ingår i: Nature cell biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 9:11, s. 1286-93
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Tidskriftsartikel (refereegranskat)abstract
- The accumulation of cytosolic lipid droplets in muscle and liver cells has been linked to the development of insulin resistance and type 2 diabetes. Such droplets are formed as small structures that increase in size through fusion, a process that is dependent on intact microtubules and the motor protein dynein. Approximately 15% of all droplets are involved in fusion processes at a given time. Here, we show that lipid droplets are associated with proteins involved in fusion processes in the cell: NSF (N-ethylmaleimide-sensitive-factor), alpha-SNAP (soluble NSF attachment protein) and the SNAREs (SNAP receptors), SNAP23 (synaptosomal-associated protein of 23 kDa), syntaxin-5 and VAMP4 (vesicle-associated membrane protein 4). Knockdown of the genes for SNAP23, syntaxin-5 or VAMP4, or microinjection of a dominant-negative mutant of alpha-SNAP, decreases the rate of fusion and the size of the lipid droplets. Thus, the SNARE system seems to have an important role in lipid droplet fusion. We also show that oleic acid treatment decreases the insulin sensitivity of heart muscle cells, and this sensitivity is completely restored by transfection with SNAP23. Thus, SNAP23 might be a link between insulin sensitivity and the inflow of fatty acids to the cell.
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| 8. |
- Domeij Bäckryd, Rebecka, 1978-
(författare)
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Multidisciplinary Design Optimization of Automotive Structures
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Multidisciplinary design optimization (MDO) can be used as an effective tool to improve the design of automotive structures. Large-scale MDO problems typically involve several groups who must work concurrently and autonomously for reasons of efficiency. When performing MDO, a large number of designs need to be rated. Detailed simulation models used to assess automotive design proposals are often computationally expensive to evaluate. A useful MDO process must distribute work to the groups involved and be computationally efficient.In this thesis, MDO methods are assessed in relation to the characteristics of automotive structural applications. Single-level optimization methods have a single optimizer, while multi-level optimization methods have a distributed optimization process. Collaborative optimization and analytical target cascading are possible choices of multi-level optimization methods for automotive structures. They distribute the design process, but are complex. One approach to handle the computationally demanding simulation models involves metamodel-based design optimization (MBDO), where metamodels are used as approximations of the detailed models during optimization studies. Metamodels can be created by individual groups prior to the optimization process, and therefore also offer a way of distributing work. A single-level optimization method in combination with metamodels is concluded to be the most straightforward way of implementing MDO into the development of automotive structures.
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| 9. |
- Eriksson, Olof, 1978-
(författare)
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Imaging Islets of Langerhans by Positron Emission Tomography : Quantification of Beta-Cell Mass in the Native Pancreas and the Islet Graft
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Type 1 and 2 Diabetes Mellitus are a growing health problem throughout the world. There is an increasing need for methodologies, which are both reliable and non-invasive to measure the amount of insulin-producing tissue (Beta-cell mass, or BCM), as well as rapidly quantify changes in the BCM due to the onset of disease, beta-cell replacement therapy, or other treatments. Positron Emission Tomography (PET) is a non-invasive, quantitative functional imaging technique which can be used to study dynamical or static processes inside the body. In this thesis, we present a study protocol for in vivo imaging of the most common form of beta- cell replacement therapy; islet transplantation. Islets were labeled with the PET tracer, 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG), and administered intra-portally, while the recipient was monitored by PET/CT. The hepatic distribution of the islets was highly heterogeneous, and around 25% (human) or 50% (porcine) of the administered islets could not be found in the liver after completed transplantation, confirming previous reports of considerable cell injury during the procedure leading to low hepatic engraftment. Native BCM in the pancreas can potentially be quantified using a PET tracer with sufficiently high specificity, but the major obstacle is the relative low amounts of insulin producing tissue (only 1-2% of the pancreatic volume). Two tetrabenazine analogues, [18F]FE-(+)-DTBZ and [18F]FE-(+)-DTBZ-d4, are ligands to VMAT2, which is expressed in islet tissue. Both analogues were investigated and characterized as potential BCM imaging agents both in vitro and in vivo. Both tracers exhibited high preferential binding to islet tissue compared to exocrine pancreatic tissue. However, the specificity was not high enough to overcome the obscuring exocrine signal in vivo (7-10% of the signal originating from specific islet tracer uptake). This thesis demonstrates that it is possible to quantitatively assess islet transplantation by PET imaging. In vivo determination of native pancreatic BCM is, in theory, possible with both [18F]FE-(+)-DTBZ and [18F]FE-(+)-DTBZ-d4, but tracer analogues with higher islet specificity is needed for quantification of smaller BCM changes with physiological impact.
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| 10. |
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| 11. |
- Håkansson, Anna, 1978, et al.
(författare)
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Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
- 2005
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Ingår i: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-4841 .- 1552-485X. ; 133:1, s. 88-92
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Tidskriftsartikel (refereegranskat)abstract
- The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (
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| 12. |
- Håkansson, Anna, 1978, et al.
(författare)
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Investigation of genes coding for inflammatory components in Parkinson's disease.
- 2005
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Ingår i: Movement disorders : official journal of the Movement Disorder Society. - : Wiley. - 0885-3185 .- 1531-8257. ; 20:5, s. 569-73
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Tidskriftsartikel (refereegranskat)abstract
- Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles. The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.
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| 13. |
- Jeppesen, H. B., et al.
(författare)
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Study of Li-10 via the Li-9(H-2, p) reaction at REX-ISOLDE
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 642:5-6, s. 449-454
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Tidskriftsartikel (refereegranskat)abstract
- The Click to view the MathML source reaction has been investigated at 2.36 MeV/u at the REX-ISOLDE facility. In this Letter we focus on the Click to view the MathML source channel which potentially holds spectroscopic information on the unbound nucleus 10Li. The experimental excitation energy spectrum and angular distribution are compared with CCBA calculations. These calculations clearly support the existence of a low-lying (s) virtual state, with a (negative) scattering length of the order asnot, vert, similar1324 fm and a p1/2 resonance with an energy of Ersimilar, equals0.38 MeV and a width of Γsimilar, equals0.2 MeV.
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| 14. |
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| 15. |
- Kjellman, Erik, 1988-, et al.
(författare)
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ROMA - State assessment of road markings in Denmark, Nor-way and Sweden : Results from 2018
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Assessments of the performance of road markings is carried out regularly to various degrees in the Nordic countries. The main aim of the Nordic road marking assessment study is to show possible differences in road marking performance between Denmark, Norway and Sweden. Possible differences between road marking performance, dependent on region, country, type of road and AADT (Annual Average Daily Traffic) are studied. Furthermore, a comparison between the TEN-T and the non-TEN-T road network is made. As 2018 is the second year of the project, a comparison between the results for 2017 and 2018 is also made. A Nordic certification system for road marking materials has recently been introduced in Norway and Denmark and will be introduced in Sweden 2019. This means that a documented product approval (i.e. certification) will be required for use of the material on roads managed by the national road authorities. The requirements are introduced successively as the existing contracts expire. Therefore, one aim is also to study the road marking quality before and under the introduction of the new certification requirements. Continuous assessments give the opportunity to react and adjust the requirements in the future, if the performance does not develop as expected. The study is based on physical mobile road assessment measurements carried out in Denmark, Norway and Sweden by Ramböll. In total 71 road objects were measured in Denmark, 124 in Norway and 434 in Sweden. The following variables were studied: retroreflectivity of dry and wet road markings, relative visibility of dry and wet road markings, relative pre-view-time (pvt) of dry and wet road markings and cover index.
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| 16. |
- Madurga, M., et al.
(författare)
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Evidence of a new state in Be-11 observed in the Li-11 beta-decay
- 2009
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 677:5, s. 255-259
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Tidskriftsartikel (refereegranskat)abstract
- Coincidences between charged particles emitted in the beta-decay of Li-11 were observed using highly segmented detectors. The breakup channels involving three particles were Studied in full kinematics allowing for the reconstruction of the excitation energy of the Be-11 states participating in the decay. In particular, the contribution of a previously unobserved state at 16.3 MeV in Be-11 has been identified selecting the alpha + He-7 -> alpha + He-6 + n channel. The angular correlations between the alpha particle and the center of mass of the He-6 + n system favors spin and parity assignment of 3/2(-) for this state as well as for the previously known state at 18 MeV. (C) 2009 Elsevier B.V. All rights reserved.
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| 17. |
- Madurga, M., et al.
(författare)
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Kinematic identification of the t branch in the decay of 11Li
- 2009
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 42:3, s. 415-419
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Tidskriftsartikel (refereegranskat)abstract
- The -delayed 8 Li + t branch of the 11Li decay was identified via kinematical analysis of the charged particles observed in coincidence. The back-to-back events observed in a narrow angular acceptance were compared to a Monte Carlo simulation. The 8 Li + t sum energy spectrum was fitted assuming that the decay occurs through an intermediate state in 11Be . The resulting energy centroid and full-width half maximum for the intermediate state are 18.35(30)MeV and 1.5(4)MeV, respectively. The -delayed 8 Li + t branching ratio obtained from the coincidence spectrum, BR t = 0.93(8)×10-4 , is in agreement with previous measurements but more precise.
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| 18. |
- Madurga, M., et al.
(författare)
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Study of $[$beta$]$-delayed 3-body and 5-body breakup channels observed in the decay of 11Li
- 2008
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Ingår i: Nuclear Physics A. - : Elsevier BV. ; 810, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- The [beta]-delayed charged particle emission from 11Li has been studied with emphasis on the three-body n[alpha]6He and five-body 2[alpha]3n channels from the 10.59 and 18.15 MeV states in 11Be. Monte Carlo simulations using an R-matrix formalism lead to the conclusion that the AHe resonance states play a significant role in the break-up of these states. The results exclude an earlier assumption of a phase-space description of the break-up process of the 18.15 MeV state. Evidence for extra sequential decay paths is found for both states.
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| 19. |
- Marganiec, C., et al.
(författare)
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Coulomb breakup of 17Ne from the viewpoint of nuclear astrophysics
- 2013
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Ingår i: Proceedings of Science.
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Konferensbidrag (refereegranskat)abstract
- By the Coulomb breakup of 17Ne, the time-reversed reaction 15O(2p,γ)17Ne has been studied. This reaction might play an important role in the rp process, as a break-out reaction of the hot CNO cycle. The secondary 17Ne ion beam with an energy of 500 MeV/nucleon has been dissociated in a Pb target. The reaction products have been detected with the LAND-R3B experimental setup at GSI. The preliminary differential and integral Coulomb dissociation cross section sCoul has been determined, which then will be converted into a photo-absorption cross section sphot o, and a two-proton radiative capture cross section σcap. Additionally, information about the structure of the 17Ne, a potential two-proton halo nucleus, will be received. The analysis is in progress.
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| 20. |
- Marganiec, J., et al.
(författare)
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Experimental study of the O-15(2p, gamma) Ne-17 cross section by Coulomb Dissociation for the rp process
- 2016
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1
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Konferensbidrag (refereegranskat)abstract
- The time-reversed reaction O-15(2p, gamma) Ne-17 has been studied by the Coulomb dissociation technique. Secondary 17Ne ion beams at 500 AMeV have been produced by fragmentation reactions of Ne-20 in a beryllium production target and dissociated on a secondary Pb target. The incoming beam and the reaction products have been identified with the kinematically complete LAND-(RB)-B-3 experimental setup at GSI. The excitation energy prior to decay has been reconstructed by using the invariant-mass method. The preliminary differential and integral Coulomb Dissociation cross sections (sigma(Coul)) have been calculated, which provide a photoabsorption (sigma(photo)) and a radiative capture cross section (sigma(cap)). Additionally, important information about the nuclear structure of the Ne-17 nucleus will be obtained. The analysis is in progress.
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| 21. |
- Nilsson, Olof, 1978-, et al.
(författare)
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Ultrasound accurately assesses depth of invasion in T1-T2 oral tongue cancer
- 2022
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Ingår i: Laryngoscope Investigative Otolaryngology (LIO). - : John Wiley & Sons. - 2378-8038. ; 7:5, s. 1448-1455
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Tidskriftsartikel (refereegranskat)abstract
- Background: Depth of invasion (DOI) is important for the T-classification of squamous cell carcinoma of the oral tongue (SCCOT) and incorporated in the TNM 8 classification of oral cavity cancer. To determine DOI clinical palpation is performed, but the preferred radiological modality remains controversial. The aim of this study was to investigate the assessment of DOI using ultrasound (US-DOI).Methods: The DOI was assessed in 40 patients with T1-T3 SCCOT by ultrasound, palpation, computed tomography and magnetic resonance imaging (MRI). Histopathological DOI (H-DOI) was gold standard. Bland-Altman analysis was used to compare mean difference and 95% limits of agreement (LOA). Results The mean difference of US-DOI was -0.5 mm (95% LOA -4.9-4.0) compared to H-DOI and the mean difference for MRI was 3.9 mm (95% LOA -2.3-10.2). In the subgroup analysis of cT1-T2 the US-DOI mean difference was 0.1 mm and the 95% LOA limits -2.5-2.7.Conclusions: Ultrasound seems to be the most accurate method to assess DOI in T1-T2 SCCOT. MRI overestimates DOI and cannot assess a substantial proportion of the tumors. Level of Evidence 2c.
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| 22. |
- Nilsson, Olof, 1978-, et al.
(författare)
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Ultrasound-assisted resection of oral tongue cancer
- 2022
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Ingår i: Acta Oto-Laryngologica. - : Taylor & Francis. - 0001-6489 .- 1651-2251. ; 142:9-12, s. 743-748
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In surgical resection of squamous cell carcinoma of the oral tongue (SCCOT), achieving clear margins is important for prognosis. Insufficient histopathological margins are common, particularly deep margins.AIMS/OBJECTIVES: The aim of the present study was to determine whether ultrasound (US)-assisted resection could decrease the proportion of insufficient histopathological deep margins in SCCOT.MATERIAL AND METHODS: 34 patients with SCCOT undergoing US-assisted resection (study group) were compared to 76 whose resections were performed without US (conventional group). Outcome measures were insufficient deep histopathological resection margins and mean difference in deep margins.RESULTS: Insufficient deep resection margins (<5.0 mm) were seen in 8 of 34 (23.5%) in the study group, compared to 31 of 76 (40.8%) in the conventional group, unadjusted RR 0.58 [95% CI 0.30-1.12; p = .11], adjusted RR 0.82 [95% CI 0.35-1.92; p = .64]. Unadjusted mean difference was 1.4 mm (95% CI 0.1-2.7, p = .04), adjusted mean difference 1.1 mm (95% CI -2.7 to 0.5, p = .19).CONCLUSIONS: Intraoperative US can visualize the deep resection margins in T1/T2 SCCOT. US-assisted resection seems to decrease the number of insufficient histopathological deep margins, though the results are not statistically significant. Comparatively good results in the conventional group is one explanation for the lack of significance.CLINICALTRIALS.GOV ID: NCT04059861.
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| 23. |
- Tengborn, Elisabeth, 1978, et al.
(författare)
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The 8Li + 2H reaction studied in inverse kinematics at 3.15 MeV/nucleon using the REX-ISOLDE post-accelerator
- 2011
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 84:6, s. 064616-
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Tidskriftsartikel (refereegranskat)abstract
- The reaction 8Li + 2H has been studied in inverse kinematics at the incident energy of 3.15 MeV/nucleon, using the REX-ISOLDE post-accelerator. The reaction channels corresponding to (d,p), (d,d), and (d,t) reactions populating ground states and low-lying excited states in 7–9Li have been identified and the related angular distributions extracted and compared with coupled-channels, distorted-wave Born approximation (DWBA), and coupled-reaction-channels calculations. For the inelastic and (d,t) channels we find that higher order effects are very important and hence one needs to go beyond the simple DWBA to extract reliable structure information from these processes.
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| 24. |
- Tomecek, David, 1991, et al.
(författare)
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Neural network enabled nanoplasmonic hydrogen sensors with 100 ppm limit of detection in humid air
- 2024
-
Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Environmental humidity variations are ubiquitous and high humidity characterizes fuel cell and electrolyzer operation conditions. Since hydrogen-air mixtures are highly flammable, humidity tolerant H2 sensors are important from safety and process monitoring perspectives. Here, we report an optical nanoplasmonic hydrogen sensor operated at elevated temperature that combined with Deep Dense Neural Network or Transformer data treatment involving the entire spectral response of the sensor enables a 100 ppm H2 limit of detection in synthetic air at 80% relative humidity. This significantly exceeds the <1000 ppm US Department of Energy performance target. Furthermore, the sensors pass the ISO 26142:2010 stability requirement in 80% relative humidity in air down to 0.06% H2 and show no signs of performance loss after 140 h continuous operation. Our results thus demonstrate the potential of plasmonic hydrogen sensors for use in high humidity and how neural-network-based data treatment can significantly boost their performance.
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| 25. |
- Vadeby, Anna, 1969-, et al.
(författare)
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ROMA : State assessment of road markings in Denmark, Norway and Sweden - Results from 2017
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Assessment of the performance of road markings are carried out regularly to various degrees in the Nordic countries. During the coming years, the Nordic certification system for road marking materials will come into force, which means that a documented product approval (i.e. certification) will be required for use of the material on roads managed by the national road authorities. The requirements are introduced successively as the existing contracts expire. The aim of this project is to monitor and follow up how road marking quality is influenced by the introduction of the certification system in Denmark, Norway and Sweden. If the performance does not develop as expected, continuous assessments give the opportunity to react and adjust the requirements in the future. Furthermore, the aim is to show possible differences in road marking performance between the three countries, similar regions in the three countries and TEN-T-roads.The study is based on mobile road assessment measurements carried out in Denmark, Norway and Sweden by Ramböll AB. In total 71 road objects were measured in Denmark, 101 in Norway and 436 in Sweden. The following variables were studied: retroreflectivity of dry and wet road markings, relative visibility of dry and wet road markings, relative pre-view-time (pvt) of dry and wet road markings and cover index.In conclusion, there is no large difference in road marking performance in the three countries. The only significant difference is the poor visibility of edge lines on two-lane roads in Sweden and the good performance of wet road markings in Norway.
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| 26. |
- Vadeby, Anna, 1969-, et al.
(författare)
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ROMA : State assessment of road markings in Denmark, Norway and Sweden 2017–2021
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Assessments of the performance of road markings is carried out regularly to various degrees in the Nordic countries. The main aim of the Nordic road marking assessment study is to show possible differences in road marking performance between Denmark, Norway and Sweden. Possible differences between road marking performance, dependent on region, country, type of road and AADT (Annual Average Daily Traffic) are studied. Furthermore, a comparison between the TEN-T and the non-TEN-T road network is made. As 2018 is the second year of the project, a comparison between the results for 2017 and 2018 is also made.A Nordic certification system for road marking materials has recently been introduced in Norway and Denmark and will be introduced in Sweden 2019. This means that a documented product approval (i.e. certification) will be required for use of the material on roads managed by the national road authorities. The requirements are introduced successively as the existing contracts expire. Therefore, one aim is also to study the road marking quality before and under the introduction of the new certification requirements. Continuous assessments give the opportunity to react and adjust the requirements in the future, if the performance does not develop as expected.The study is based on physical mobile road assessment measurements carried out in Denmark, Norway and Sweden by Ramböll. In total 71 road objects were measured in Denmark, 124 in Norway and 434 in Sweden. The following variables were studied: retroreflectivity of dry and wet road markings, relative visibility of dry and wet road markings, relative pre-view-time (pvt) of dry and wet road markings and cover index.The results show that the retroreflectivity requirement of dry road markings (150 mcd/m2/lx) is roughly fulfilled in 50 % of the measured objects. Road markings in Denmark have lower retroreflectivity than those in Norway and Sweden. Some retroreflectivity values are low, e.g. motorway edge lines in Denmark. However, this is compensated for by a large area, which nevertheless means good visibility. Contrary: edge lines on Swedish two-lane roads have high retroreflectivity, which would imply good visibility. However, the road marking area is small, thus reducing the visibility in comparison with both Danish and Norwegian edge lines.Regarding wet road markings, road markings in Norway have higher retroreflectivity than Denmark and Sweden for every road class. This can probably be explained by the fact that Norway often has inlaid road markings, a solution seldom used in Denmark and Sweden. When analysing the results for wet road markings it should be noted that significant deviations be-tween the results from the mobile measurements and the hand-held measurements were shown during the annual validation of mobile instruments in 2017 and 2018 and therefore, the results for wet road markings should be interpreted with care.A comparison between the retroreflectivity on the Trans-European Transport Network (TEN-T) and other roads showed that there were only minor differences between the TEN-T and other roads in Denmark, while in Norway and Sweden there are somewhat higher levels for the TEN-T network. The results for relative visibility show larger differences between TEN-T and non-TEN-T and in all three countries, the relative visibility is higher for the TEN-T road network. However, studying the rela-tive pre-view-time shows that in all countries, this measure is lower on the TEN-T roads, due to higher speed limits on the TEN-T road network. For Norway and Sweden, the differences in pvt between TEN-T and other roads are rather small, while for Denmark the difference is significant, and the relative pre-view time is about 0.6 s shorter on the TEN-T roads than on other roads.There is no significant difference in cover index between the countries, but between road classes the difference is significant. Lane and centre lines seem to have a higher cover index than edge lines. This is difficult to explain, but the reason might be that lane and centre lines are reconditioned almost every year, due to many wheel roll overs. If so, measurements were car-ried out on almost new lane and centre lines, while the edge lines might have been applied in earlier years. Another explanation might be that the edge lines are profiled to a higher extent than the lane and centre lines.In the second year of the project, it is not possible to study any effect of the Nordic certification system for road markings. However, in the coming years, some effects might be possible to register.In conclusion, there is no large difference in road marking performance between the three countries and comparing the re-sults between 2017 and 2018 shows no major differences on country level. For both 2017 and 2018 the main conclusion is the poor visibility of edge lines on two-lane roads in Sweden and the good performance of wet road markings in Norway.
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