| 1. |
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| 2. |
- Ekström, Magnus Pär, et al.
(författare)
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The association of body mass index, weight gain and central obesity with activity-related breathlessness : the Swedish Cardiopulmonary Bioimage Study
- 2019
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Ingår i: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 74:10, s. 958-964
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m(2)) is rapidly increasing globally and its impact on breathlessness is unclear.Methods: This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score >= 1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.Results: We included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m(2); and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.Conclusion: Breathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.
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| 3. |
- Nilsson, Hanna, et al.
(författare)
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Incidence of groin hernia repair after radical prostatectomy : a population-based nationwide study
- 2014
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Ingår i: Annals of Surgery. - 0003-4932 .- 1528-1140. ; 259:6, s. 1223-1227
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess the incidence of groin hernia repair after radical prostatectomy for prostate cancer compared with the incidence in a control population without prostate cancer in a nationwide, population-based study.Background: Recent reports indicate an increase in the incidence of groin hernia repair after radical prostatectomy. Inadequate knowledge of the incidence of groin hernia in the general population makes this information hard to interpret.Methods: Information was retrieved from the Prostate Cancer Database (PCBaSe) and Swedish Hernia Register for events between 1998 and 2010. The incidence of groin hernia surgery was calculated for a group of men treated with radical prostatectomy (open and minimally invasive) and for a group treated with radiation therapy, and these were compared with the incidence in a control cohort of men matched for age and county of residence. Multivariate analysis was used to assess the hazard ratio (HR) of groin hernia repair according to age, tumor risk category, and Charlson Comorbidity Index.Results: A total of 28,608 cases and 105,422 controls were included in the study. Men treated with radical prostatectomy and radiation therapy had a significantly higher incidence of groin hernia repair than the control cohort: HR: 3.95 (95% confidence interval: 3.70-4.21) for retropubic prostatectomy, HR: 3.37 (95% confidence interval: 2.95-3.87) for minimally invasive prostatectomy, and HR: 1.84 (95% confidence interval: 1.66-2.04) for radiation therapy.Conclusions: An almost 4-fold increase in groin hernia repair was observed after radical prostatectomy compared with controls, and men who received radiation therapy had an almost 2-fold increase in incidence. As well as postoperative changes in the abdominal wall, increased vigilance for groin hernia seems to be important for the increased incidence of groin hernia repair seen after radical prostatectomy or radiation therapy for prostate cancer.
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| 4. |
- Nilsson, Hanna, 1979-, et al.
(författare)
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Mortality after groin hernia surgery : delay of treatment and cause of death
- 2011
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Ingår i: Hernia. - Paris : Springer. - 1265-4906 .- 1248-9204. ; 15:3, s. 301-307
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Emergency hernia surgery, in contrast to elective hernia surgery, is associated with appreciable mortality. Incarcerated hernia is the second most common cause of small bowel obstruction after adhesions, and the leading cause of bowel strangulation.METHODS: Information on patients who died within 30 days of groin hernia surgery was retrieved from the Swedish Hernia Register, from the Cause-of-Death Register, and from hospital notes.RESULTS: Of 103,710 groin hernia operations between 1992 and 2004, 292 patients died within 30 days of surgery. Hospital notes and cause of death were retrieved for 242 cases (82%). In 5 of these patients, the hernia operation was done in addition to more urgent surgery and therefore excluded from further analyses; 152 patients were admitted as emergency cases and 55 of these patients underwent bowel resection. A total of 107 patients had signs of bowel obstruction when admitted. For 37% of these patients, physical examination of the groin was not documented. Patients with bowel obstruction without a note on a palpable groin lump were more likely to undergo imaging investigation preoperatively (P < 0.001) and they had an increased time to surgery compared to patients with a palpable lump. Women and patients with femoral hernia were significantly less likely to undergo a groin examination compared to other patients. Local anaesthesia was used in 7% of all patients who died postoperatively, and in 3% of emergency cases. Pulmonary disease, sepsis and malignant disease were more common as causes of death after emergency surgery than after elective surgery.CONCLUSIONS: Groin examination of patients presenting with bowel obstruction is of utmost importance in order to minimise delay to hernia surgery.
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| 5. |
- Nilsson, Hanna, et al.
(författare)
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Mortality after groin hernia surgery
- 2007
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Ingår i: Annals of Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0003-4932 .- 1528-1140. ; 245:4, s. 656-660
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To analyze mortality following groin hernia operations.Summary Background Data: It is well known that the incidence of groin hernia in men exceeds the incidence in women by a factor of 10. However, gender differences in mortality following groin hernia surgery have not been explored in detail.Methods: The study comprises all patients 15 years or older who underwent groin hernia repair between January 1, 1992 and December 31, 2005 at units participating in the Swedish Hernia Register (SHR). Postoperative mortality was defined as standardized mortality ratio (SMR) within 30 days, ie, observed deaths of operated patients over expected deaths considering age and gender of the population in Sweden.Results: A total of 107,838 groin hernia repairs (103,710 operations), were recorded prospectively. Of 104,911 inguinal hernias, 5280 (5.1%) were treated emergently, as compared with 1068 (36.5%) of 2927 femoral hernias. Femoral hernia operations comprised 1.1% of groin hernia operations on men and 22.4% of operations on women. After femoral hernia operation, the mortality risk was increased 7-fold for both men and women. Mortality risk was not raised above that of the background population for elective groin hernia repair, but it was increased 7-fold after emergency operations and 20-fold if bowel resection was undertaken. Overall SMR was 1.4 (95% confidence interval, 1.2-1.6) for men and 4.2 (95% confidence interval, 3.2-5.4) for women, in accordance with a greater proportion of emergency operations among women compared with men, 17.0%, versus 5.1%.Conclusions: Mortality risk following elective hernia repair is low, even at high age. An emergency operation for groin hernia carries a substantial mortality risk. After groin hernia repair, women have a higher mortality risk than men due to a greater risk for emergency procedure irrespective of hernia anatomy and a greater proportion of femoral hernia.
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| 6. |
- Schön Persson, Sophie, et al.
(författare)
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Resources for work-related well-being : A qualitative study about healthcare employees' experiences of relationships at work
- 2018
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 27:23-24, s. 4302-4310
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Tidskriftsartikel (refereegranskat)abstract
- Aims and objectives: To explore municipal healthcare employees' experiences of relationships with care recipients and colleagues. The specific research questions were when do the relationships enhance well-being, and what prerequisites are needed for such relationships to occur? Background: Employees in health and social care for older people often depict their work in negative terms, and they often take a high number of sick leaves. Despite the heavy workload, other employees express well-being at work and highlight social relationships as one reason for this. However, a greater understanding of how these relationships can act as resources for workplace well-being is needed. Design: The design of the study was qualitative and exploratory. Methods: Qualitative interview studies were conducted with 23 healthcare employees in municipal health care. Thematic analysis was used to analyse the data. Results: Two themes were identified as resources for promoting relationships between employees and care recipients or colleagues: (a) Being personal-a close interpersonal relationship to a care recipient-and (b) Colleague belongingness-a sense of togetherness within the working group. Spending quality time together, providing long-term care and providing additional care were prerequisites for a close interpersonal relationship with care recipients. Trust, mutual responsibility and cooperation were prerequisites for a sense of togetherness within the working group. Conclusions: The findings provide an empirical base to raise awareness of relationships with care recipients and colleagues as health aspects. Relationships among employees in health care are vital resources that must be considered to create sustainable workplaces and consequently improve the quality of care. Relevance to clinical practice: The results of this study advocate health promotion efforts based on interpersonal relationships at the workplace. Dialogues in the working groups, based on the employees' experiences of positive daily situations, may be a promoting method for the work-related well-being of the employees.
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| 7. |
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| 8. |
- Acosta Ruiz, Vanessa, 1987-, et al.
(författare)
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Split renal function after treatment of small renal masses : comparison between radiofrequency ablation and laparoscopic partial nephrectomy.
- 2021
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Ingår i: Acta Radiologica. - : Sage Publications. - 0284-1851 .- 1600-0455. ; 62:9, s. 1248-1256
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Radiofrequency ablation (RFA) and laparoscopic partial nephrectomy (LPN) are used to treat small renal masses (SRM; ≤4 cm), although there are conflicting results in the changes in creatinine and estimated glomerular filtration rate (eGFR) after treatment. On contrast-enhanced computed tomography (CE-CT) images, the quantity and quality of renal function can be evaluated by calculating the split renal function (SRF).PURPOSE: To compare renal function after RFA or LPN treatment of SRMs through evaluation of the SRF in the affected kidney.MATERIAL AND METHODS: Single T1a renal tumors successfully treated with RFA (n = 60) or LPN (n = 31) were retrospectively compared. The SRF was calculated on pre-treatment CE-CT images and the first follow-up exam after completed treatment. Serum creatinine and eGFR values were collected simultaneously. To compare renal function outcomes, Student's t-test and multivariable linear regression models (adjusted to RFA/LPN treatment, pre-treatment SRF/eGFR, BMI, age, tumor characteristics, and Charlson Comorbidity Index) were used.RESULTS: SRF was reduced in both groups, although reduction was greater in the LPN group (LPN -5.7%) than in the RFA group (RFA -3.5%; P = 0.013). After adjusted analysis, the LPN group still had greater SRF reduction (difference 3.2%, 95% confidence interval 1.3-1.5; P = 0.001). There was no difference between groups in the change of creatinine/eGFR after treatment.CONCLUSION: Both RFA and LPN are nephron-sparing when treating SRMs. However, in this series, reduction of SRF in the affected kidney was smaller after RFA, having a more favorable preservation of renal function than LPN.
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| 9. |
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| 10. |
- Aidas, Kestutis, et al.
(författare)
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On the performance of quantum chemical methods to predict solvatochromic effects: The case of acrolein in aqueous solution.
- 2008
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 128:19, s. 1-194503
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Tidskriftsartikel (refereegranskat)abstract
- The performance of the Hartree-Fock method and the three density functionals B3LYP, PBE0, and CAM-B3LYP is compared to results based on the coupled cluster singles and doubles model in predictions of the solvatochromic effects on the vertical n-->pi(*) and pi-->pi(*) electronic excitation energies of acrolein. All electronic structure methods employed the same solvent model, which is based on the combined quantum mechanics/molecular mechanics approach together with a dynamical averaging scheme. In addition to the predicted solvatochromic effects, we have also performed spectroscopic UV measurements of acrolein in vapor phase and aqueous solution. The gas-to-aqueous solution shift of the n-->pi(*) excitation energy is well reproduced by using all density functional methods considered. However, the B3LYP and PBE0 functionals completely fail to describe the pi-->pi(*) electronic transition in solution, whereas the recent CAM-B3LYP functional performs well also in this case. The pi-->pi(*) excitation energy of acrolein in water solution is found to be very dependent on intermolecular induction and nonelectrostatic interactions. The computed excitation energies of acrolein in vacuum and solution compare well to experimental data.
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| 11. |
- Ameur, Adam, et al.
(författare)
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SweGen : a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- 2017
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Ingår i: European Journal of Human Genetics. - : NATURE PUBLISHING GROUP. - 1018-4813 .- 1476-5438. ; 25:11, s. 1253-1260
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
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| 12. |
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| 13. |
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| 14. |
- Anter, Karin Fridell, et al.
(författare)
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SYN-TES INTERDISCIPLINARY RESEARCH ON COLOUR AND LIGHT
- 2012
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Ingår i: Proceedings for Interim Meeting of the International Colour Association (AIC); AIC 2012 “In Color We Live: Color and Environment”, 22 – 25 September 2012, Taipei, Taiwan. - : The International Colour Association. ; , s. 80-83, s. 80-83
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Konferensbidrag (refereegranskat)abstract
- Colour and light have largely been considered as belonging to two different fields of knowledge, having disparate theoretical, terminological and methodological traditions. This creates a ground for misunderstandings and obstructs a fruitful interdisciplinary and interprofessional collaboration. A survey over international research literature from 2006 -2011 shows that there has been only little research on the spatial interaction between colour and light, but that the interest for this area has recently increased. The interdisciplinary Nordic research project SYN-TES: Human colour and light synthesis. Towards a coherent field of knowledge was carried out during 2010-11. Colour and light experts from Nordic universities and companies investigated different aspects of the spatial interaction between colour and light and its importance for human beings. This paper deals with the general learnings from the process. Specific results are presented in other papers at this conference.
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| 15. |
- Axman, E., et al.
(författare)
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Chronic pain and risk for reoperation for recurrence after inguinal hernia repair using self-gripping mesh
- 2020
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Ingår i: Surgery. - : Elsevier BV. - 0039-6060 .- 1532-7361. ; 167:3, s. 609-613
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Tidskriftsartikel (refereegranskat)abstract
- Background: Improved recurrence rates after groin hernia surgery have led to chronic pain becoming the most troublesome postoperative complication. Self-gripping mesh was developed to decrease the risk for development of chronic pain. The aim of this nationwide cohort study was to compare recurrence rate and chronic pain 1 year after an open, anterior mesh repair of inguinal hernias with either a self-gripping mesh or other lightweight mesh. Method: All operations registered as open anterior mesh repair (Lichtenstein) in the Swedish Hernia Registry between September 2012 and October 2016 were selected. At 1 year after repair, patients were sent a pain questionnaire assessing chronic pain. We compared the prevalence of chronic pain and reoperation for recurrence using lightweight, sutured mesh or self-gripping mesh. Results: We analyzed the 1,803 repairs using self-gripping mesh and 16,567 repairs using lightweight mesh. We found no difference in the prevalence of chronic pain 1 year after the hernia repair between selfgripping mesh and sutured lightweight mesh (OR 0.92, CI 95% 0.80-1.06, P = .257). There was no increase in reoperation for recurrence when using self-gripping mesh (HR 0.71, CI 95% 0.45-1.14, P = .156). Mean operation time was considerably less when using self-gripping mesh (43 vs 70 minutes; P > .001). Conclusion: The use of self-gripping mesh does not decrease the incidence of chronic pain and reoperation for recurrence compared with lightweight, sutured mesh for open anterior mesh repair of inguinal hernias. Furthermore, the use of self-gripping mesh is associated with a clinically important, lesser operation time. (C) 2019 Elsevier Inc. All rights reserved.
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| 16. |
- Barcala, Maximiliano Estravis, et al.
(författare)
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Whole-genome resequencing facilitates the development of a 50K single nucleotide polymorphism genotyping array for Scots pine (Pinus sylvestris L.) and its transferability to other pine species
- 2024
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Ingår i: The Plant Journal. - 0960-7412 .- 1365-313X. ; 117:3, s. 944-955
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Tidskriftsartikel (refereegranskat)abstract
- Scots pine (Pinus sylvestris L.) is one of the most widespread and economically important conifer species in the world. Applications like genomic selection and association studies, which could help accelerate breeding cycles, are challenging in Scots pine because of its large and repetitive genome. For this reason, genotyping tools for conifer species, and in particular for Scots pine, are commonly based on transcribed regions of the genome. In this article, we present the Axiom Psyl50K array, the first single nucleotide polymorphism (SNP) genotyping array for Scots pine based on whole-genome resequencing, that represents both genic and intergenic regions. This array was designed following a two-step procedure: first, 192 trees were sequenced, and a 430K SNP screening array was constructed. Then, 480 samples, including haploid megagametophytes, full-sib family trios, breeding population, and range-wide individuals from across Eurasia were genotyped with the screening array. The best 50K SNPs were selected based on quality, replicability, distribution across the draft genome assembly, balance between genic and intergenic regions, and genotype–environment and genotype–phenotype associations. Of the final 49 877 probes tiled in the array, 20 372 (40.84%) occur inside gene models, while the rest lie in intergenic regions. We also show that the Psyl50K array can yield enough high-confidence SNPs for genetic studies in pine species from North America and Eurasia. This new genotyping tool will be a valuable resource for high-throughput fundamental and applied research of Scots pine and other pine species.
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| 17. |
- Beckmann, Kerri, et al.
(författare)
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Radical radiotherapy for prostate cancer : patterns of care in Sweden 1998-2016
- 2020
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Ingår i: Acta Oncologica. - : TAYLOR & FRANCIS LTD. - 0284-186X .- 1651-226X. ; 59:5, s. 549-557
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men with PCa (e.g. treatment modalities, absorbed doses, fractionation) have been collated within PCa data Base Sweden (PCBaSe). This study reports patterns of radical radiotherapy for PCa in Sweden over the past two decades. Materials and methods: All men with non-metastatic PCa (1998-2016) who received external beam radiotherapy (EBRT) or high or low dose-rate brachytherapy (HDR-BT/LDR-BT) were identified in PCBaSe. Analyses included: trends in radiation techniques, fractionation patterns and total doses over time; PCa-specific survival comparing treatment in 2007-2017 with 1998-2006; and regional variation in type of primary radiotherapy. Results: About 20,876 men underwent primary radiotherapy. The main treatment modalities include conventionally fractionated (2.0 Gy/fraction) EBRT (51%), EBRT with HDR-BT boost (27%) and hypofractionated (>2.4 Gy/fraction) EBRT (11%). EBRT with photon or proton boost and HDR-BT and LDR-BT monotherapies were each used minimally. Use of dose-escalated EBRT (>74 Gy) and moderate hypofractionation increased over time, while use of HDR-BT declined. Considerable regional variation in treatment modalities was apparent. Risk of PCa death following primary radiotherapy had declined for intermediate-risk (HR: 0.60; 95%CI 0.47-0.87) and high-risk PCa (HR: 0.72; 95%CI 0.61-0.86). Discussion: Increased use of dose escalation and hypofractionated EBRT has occurred in Sweden over the past two decades, reflecting current evidence and practice guidelines. Disease-specific outcomes have also improved. Data collected in PCBaSe provide an excellent resource for further research into RT use in PCa management.
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| 18. |
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| 19. |
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| 20. |
- Bergman, Eva, 1959-, et al.
(författare)
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Atlantic salmon and brown trout in Lake Vänern : A proposal for a co-management system
- 2014
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Ingår i: Aquatic Ecosystem Health & Management. - : Taylor & Francis Group. - 1463-4988 .- 1539-4077. ; 17:4, s. 365-373
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Tidskriftsartikel (refereegranskat)abstract
- Co-management is of increasing interest for fisheries management. We explore possibilities for, and barriers to, developing a co-management system, using threatened populations of landlocked Atlantic Salmon and Brown Trout as examples. Good management of natural resources requires not only knowledge about the resource but also suitable tools to collect information and make decisions. In large ecosystems this can be difficult because many actors are involved, and various societal borders and traditions become barriers. Vänern is the largest lake in the EU and it holds several distinct populations of large-bodied landlocked Atlantic Salmon and Brown Trout. The lake is used for commercial, subsistence, and sport fishing as well as for other recreational activities, and in Klarälven, the largest river entering Vänern, sport fishing is popular. These salmonid populations were at critically low levels during the 1960s, but a stocking program since then has maintained the fishery, and at least one wild stock appears to be recovering since being protected in 1993. Ecosystem users all have different needs: in the lake, sport fishermen say that catches of hatchery fish have declined, and commercial fishermen have focused on other species. In the river, wild salmon may be recovering: sport fishing is popular and an ongoing project investigates the possibilities for salmon to be able to circumvent hydro-electrical plants and reach historical Norwegian spawning areas. Not only do we lack information about the salmonids’ different life stages, we also lack a suitable socio-political organization to find sustainable solutions to the different needs of diverse user groups. We argue that a co-management system that enfranchises user groups in the Vänern-Klarälven ecosystem will improve sustainable management of wild and hatchery fish.
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| 21. |
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| 22. |
- Blomkvist, Pär, 1961-, et al.
(författare)
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Bridging the critical interface : Ambidextrous innovation for water provision in Nairobi's informal settlements
- 2020
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Ingår i: Technology in society. - : Elsevier Ltd. - 0160-791X .- 1879-3274. ; 60
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Tidskriftsartikel (refereegranskat)abstract
- This article examines innovation activities in water infrastructure in Nairobi, Kenya. The focus is on efforts by Nairobi City Water and Sewerage Corporation (NCWSC) to provide water services to the inhabitants in the informal areas of the city using an automated vending machine, or Pre-Paid Dispenser (PPD). In this study, we investigate what happens when a regime actor like NCWSC tries to implement an ambidextrous (two-handed) strategy: managing the existing system according to conventional practice and at the same time innovate in new technical solutions and business models to cater for unconnected users.Besides presenting our results, our aim in this article is also to introduce a research strategy for innovation studies in infrastructural systems in low-income urban areas. Three interconnected parts stand out as our contribution:First, we present a novel conceptual framework, by adding ideas from innovation studies to the Large Technical Systems approach. We investigate how regime actors can innovate to provide water to unconnected users, without expanding the system in a traditional way.Second, we propose a novel method for analysing and understanding innovation on the margins of the infrastructural system, or in our terms, innovation in the critical interface. Central to our method is, through empirical observation, to identify misalignment between the innovation (PPD) and contextual factors at the local level, where the innovation is implemented (interface misalignment), and misalignment between the innovation and the existing water regime (internal misalignment). We use a qualitative method and results forms as a basis for further research and starting point for regime actors in search of an improved ambidextrous strategy.Third, we analyse the innovation process per se. In the Nairobi case, we assess the ambidextrous innovation strategy, and claim that the PPD functions as an adapter in the critical interface, enabling the regime actors to operate in an environment of misalignment.
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| 23. |
- Blomkvist, Pär, 1961-, et al.
(författare)
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Entrepreneurship and alignment work in the Swedish water and sanitation sector
- 2023
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Ingår i: Technology in society. - : Elsevier BV. - 0160-791X .- 1879-3274. ; 74
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Tidskriftsartikel (refereegranskat)abstract
- Water and sewage (WS) systems are, like most grid based infrastructural systems, often centralised and hierarchical and the end user has almost no possibility to influence the technical standards, business models or system architecture. The preferred method for connecting new areas to the grid are underground water pipes and gravity flow for sewage. Thus, the WS system is “tightly coupled”. It is hard to change and conservative in its system culture, exhibiting a strong “momentum” or “path dependence”. In this article we investigate an unusual case in the development of WS-systems. As a rule, WS-systems, as most infrastructural systems, develop gradually through incremental innovations, and system owners/utilities traditionally build their systems “from the inside out”. In our case, we investigate a situation where the end users took the initiative to connect a residential area, Aspvik, part of the municipality of Värmdö, outside Stockholm, Sweden, to the municipal grid and thus expand the WS-system, not from the inside out, but from the outside in. Furthermore, we highlight another unusual feature: the role of a resident that acted as the “entrepreneur” in this process of WS-system expansion. The entrepreneur had unique trust building abilities in the local community, which the regime actor (the WS utility), could not match. Historically, inventor-entrepreneurs have been common, acting as “system builders” in the establishment phase of new infrastructural systems. However, entrepreneurs outside the regime are not common in the WS sector. Although atypical in mature WS systems in developed countries, these types of local initiatives or hybrid solutions are common in developing countries. In this article, we argue that there are lessons to be learnt from our case, when dealing with system expansion processes both inside and outside the Global North.
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| 24. |
- Blomkvist, Pär, et al.
(författare)
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On the Need for System Alignment in Large Water Infrastructure : Understanding Infrastructure Dynamics in Nairobi, Kenya
- 2017
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Ingår i: Water Alternatives. - : Water Alternatives. - 1965-0175. ; 10:2, s. 283-302
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Tidskriftsartikel (refereegranskat)abstract
- In this article we contribute to the discussion of infrastructural change in Africa, and explore how a new theoretical perspective may offer a different, more comprehensive and historically informed understanding of the trend towards large water infrastructure in Africa. We examine the socio-technical dynamics of large water infrastructures in Nairobi, Kenya, in a longer historical perspective using two concepts that we call intra-systemic alignment and inter-level alignment. Our theoretical perspective is inspired by Large Technical Systems (LTS) and Multi-Level Perspective (MLP). While inter-level alignment focuses on the process of aligning the technological system at the three levels of niche, regime and landscape, intra-systemic alignment deals with how components within the regime are harmonised and standardised to fit with each other. We pay special attention to intrasystemic alignment between the supply side and the demand side, or as we put it, upstream and downstream components of a system. In narrating the history of water supply in Nairobi, we look at both the upstream (largescale supply) and downstream activities (distribution and payment), and compare the Nairobi case with European history of large infrastructures. We emphasise that regime actors in Nairobi have dealt with the issues of alignment mainly to facilitate and expand upstream activities, while concerning downstream activities they have remained incapable of expanding service and thus integrating the large segment of low-income consumers. We conclude that the present surge of large-scale water investment in Nairobi is the result of sector reforms that enabled the return to a long tradition – a 'Nairobi style' – of upstream investment mainly benefitting the highincome earners. Our proposition is that much more attention needs to be directed at inter-level alignment at the downstream end of the system, to allow the creation of niches aligned to the regime.
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| 25. |
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| 26. |
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| 27. |
- Bonde, Tiago M., et al.
(författare)
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Risk of prostate cancer death after radical radiotherapy with neoadjuvant and adjuvant therapy with bicalutamide or gonadotropin-releasing hormone agonists
- 2023
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 62:12, s. 1815-1821
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Tidskriftsartikel (refereegranskat)abstract
- Background: Oncological outcome after radical radiotherapy (RRT) combined with neoadjuvant and adjuvant androgen suppression therapy (AST) may differ according to type of AST. The aim of this nationwide register-based study was to investigate risk of prostate cancer (Pca) death after different neoadjuvant and adjuvant ASTs; (i) bicalutamide, (ii) gonadotropin-releasing hormone agonists (GnRH) or (iii) combined bicalutamide and GnRH (CAB), together with RRT.Materials and MethodsData for 6882 men diagnosed with high-risk Pca between 2007 and 2020 and treated with primary RRT was retrieved from Prostate Cancer data Base Sweden (PCBaSe) 5.0. Time to Pca death according to type of neoadjuvant and adjuvant AST was assessed by use of Kaplan-Meier plots and Cox proportional hazard models adjusted for putative confounders.Results: Data were stratified by RRT type since the effect of AST in risk of Pca death differed according to type of RRT. Compared with the reference RRT combined with neoadjuvant CAB/adjuvant GnRH, risk of Pca death for men treated with CAB/bicalutamide and conventionally fractionated external beam radiotherapy (CF-EBRT) was hazard ratio (HR) 0.73 (95% CI: 0.50-1.04), hypofractionated EBRT (HF-EBRT), HR 1.35 (95% CI: 0.65-2.81) and EBRT with high dose rate brachytherapy (EBRT-HDRBT), HR 0.85 (95% CI: 0.37-1.95). Risk of Pca death for men treated with bicalutamide/bicalutamide and: (i) CF-EBRT was HR 2.35 (95% CI: 1.42-3.90), (ii) HF-EBRT, HR 0.70 (95% CI: 0.26-1.85), (iii) HF-EBRT, HR 4.07 (95% CI: 1.88-8.77) vs the reference.Conclusion: In this observational study, risk of Pca death between men receiving different combinations of AST varied according to RRT type. No difference was found in risk of Pca death for men treated with bicalutamide or GnRH as adjuvant therapy to RRT following neoadjuvant CAB. Risk of Pca death was increased for men with monotherapy neo-/adjuvant bicalutamide in combination with CF-EBRT or EBRT-HDRBT.
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| 28. |
- Bosco, Cecilia, et al.
(författare)
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Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events
- 2017
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Ingår i: International Journal of Radiation Oncology, Biology, Physics. - : ELSEVIER SCIENCE INC. - 0360-3016 .- 1879-355X. ; 97:5, s. 1026-1031
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa).Patients and Methods: We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age-and county-matched comparison cohort of PCa-free men (n = 46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression.Results: Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis.Conclusion: Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.
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| 29. |
- Bratt, Ola, et al.
(författare)
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The Study of Active Monitoring in Sweden (SAMS) : A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer
- 2013
-
Ingår i: Scandinavian Journal of Urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 47:5, s. 347-355
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Forskningsöversikt (refereegranskat)abstract
- Objective. Only a minority of patients with low-risk prostate cancer needs treatment, but the methods for optimal selection of patients for treatment are not established. This article describes the Study of Active Monitoring in Sweden (SAMS), which aims to improve those methods. Material and methods. SAMS is a prospective, multicentre study of active surveillance for low-risk prostate cancer. It consists of a randomized part comparing standard rebiopsy and follow-up with an extensive initial rebiopsy coupled with less intensive follow-up and no further scheduled biopsies (SAMS-FU), as well as an observational part (SAMS-ObsQoL). Quality of life is assessed with questionnaires and compared with patients receiving primary curative treatment. SAMS-FU is planned to randomize 500 patients and SAMS-ObsQoL to include at least 500 patients during 5 years. The primary endpoint is conversion to active treatment. The secondary endpoints include symptoms, distant metastases and mortality. All patients will be followed for 10-15 years. Results. Inclusion started in October 2011. In March 2013, 148 patients were included at 13 Swedish urological centres. Conclusions. It is hoped that the results of SAMS will contribute to fewer patients with indolent, low-risk prostate cancer receiving unnecessary treatment and more patients on active surveillance who need treatment receiving it when the disease is still curable. The less intensive investigational follow-up in the SAMS-FU trial would reduce the healthcare resources allocated to this large group of patients if it replaced the present standard schedule.
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| 30. |
- Byström, Pär, et al.
(författare)
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Substitution of top predators : effects of pike invasion in a subarctic lake
- 2007
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Ingår i: Freshwater Biology. - : John Wiley & Sons, Inc. - 0046-5070 .- 1365-2427. ; 52:7, s. 1271–1280-
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Tidskriftsartikel (refereegranskat)abstract
- 1. Invasions of top predators may have strong cascading effects in ecosystems affecting both prey species abundance and lower trophic levels. A recently discussed factor that may enhance species invasion is climate change and in this context, we studied the effects of an invasion of northern pike into a subarctic lake ecosystem formerly inhabited by the native top predator Arctic char and its prey fish, ninespined stickleback. 2. Our study demonstrated a strong change in fish community composition from a system with Arctic char as top predator and high densities of sticklebacks to a system with northern pike as top predator and very low densities of sticklebacks. A combination of both predation and competition from pike is the likely cause of the extinction of char. 3. The change in top predator species also cascaded down to primary consumers as both zooplankton and predator-sensitive macroinvertebrates increased in abundance. 4. Although the pike invasion coincided with increasing summer temperatures in the study area we have no conclusive evidence that the temperature increase is the causal mechanism behind the pike invasion. But still, our study provides possible effects of future pike invasions in mountain lakes related to climate change. We suggest that future pike invasions will have strong effects in lake ecosystems, both by replacing native top consumers and through cascading effects on lower trophic levels.
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| 31. |
- Bäckerud, Erik, et al.
(författare)
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Så används Svenska Akademiens ordböcker på nätet. Implicit och explicit feedback från användarna
- 2021
-
Ingår i: Nordiska studier i lexikografi 15. Red. av. C. Sandström, U.-M. Forsberg, C. af Hällström-Reijonen, M. Lehtonen & K. Ruppel. - 1894-4663 .- 2246-7823. - 9789527359037
-
Konferensbidrag (refereegranskat)abstract
- This study presents and analyses search strings and user data for different Swedish lexicographical websites. The underlying empirical material was sourced from two relatively new websites, www.saob.se and the joint dictionary portal www.svenska.se, which collects and provides a single point of entry to three Swedish monolingual dictionaries financed by the Swedish Academy. Statistics are presented on the most common search strings, when and where the searches take place, and what devices and digital platforms that are commonly used while visiting the sites. In addition, the study addresses a number of questions and other forms of feedback received from dictionary users. Furthermore, the study provides suggestions and examples of how the collected data can be utilised in upcoming updates and revisions of the dictionaries.
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| 32. |
- Carlsson, Christina, et al.
(författare)
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Benefits from membership in cancer patient associations: relations to gender and involvement.
- 2006
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Ingår i: Acta oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 45:5, s. 559-563
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Tidskriftsartikel (refereegranskat)abstract
- Cancer patient associations report a growing number of members and increasing possibilities to influence health care, but knowledge about the members' views on the benefit of involvement is scarce. We therefore investigated how members (n = 1742) of Swedish patient associations for breast cancer and prostate cancer rate the benefit of membership for their physical and psychological well-being and social adjustment to cancer. Using a scoring scale, 2/3 of the members reported that membership had benefit for psychological well-being, whereas half of the members reported benefit for physical well-being and social adjustment. Individuals who had been actively involved in board work and/or contact person activities within the associations reported significantly more benefit for all three parameters. Gender differences were observed with men, represented by individuals affected by prostate cancer, reporting greater benefit for all three parameters, although especially evident for psychological well-being. Individuals who obtained membership within two years of diagnosis reported greater benefit for psychological well-being and social adjustment compared to those who became members later. In conclusion, members in patient associations for cancer report benefit particularly for their psychological well-being and actively involved members and men affected by prostate cancer perceive the greatest benefit from membership.
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| 33. |
- Carlsson, Martin, et al.
(författare)
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Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D
- 2017
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - : Taylor & Francis. - 0036-5513 .- 1502-7686. ; 77:1, s. 45-52
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Tidskriftsartikel (refereegranskat)abstract
- In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 +/- 2.0 years) total 25(OH)D was measured by LC-MS/MS (n=78), free 25(OH)D with ELISA (n=64 of 78), and bioavailable 25(OH)D was calculated. Analysis of ery-FA composition was by gas chromatography (n=56 of 78). A strong correlation between total 25(OH)D and free 25(OH)D was seen (r=.66, p<.001), and between total-25(OH)D and bioavailable 25(OH)D (r=.68, p<.001). No correlations between 25(OH)D fractions and specific fatty acids were found, and in particular, no associations with mono- and poly-unsaturated FA compositions. All 25(OH)D fractions were correlated with leptin (total 25(OH)D (r=-.33, p<.003); bioavailable 25(OH)D (r=-.47, p<.001); free 25(OH)D (r=-.44, p<.001). Associations were found between PTH and total 25(OH)D (r=-.35, p=.002) and weaker between bioavailable 25(OH)D (r=-.35, p=.040) and free 25(OH)D (r=-.28, p=.079). All fractions of 25(OH)D appear to correlate in a similar way to PTH, BMI and body fat (leptin). No association was found between ery-FA composition and free/bioavailable 25(OH)D. It is unlikely that FAs are a strong uncoupling factor of DBP-bound 25(OH)D.
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| 34. |
- Carlsson, Martin, et al.
(författare)
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Evidence of Daytime Variation of Asymmetric Dimethylarginine: An Intervention Study with Rosiglitazon in Type 2 Diabetes
- 2011
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Ingår i: The Open Endocrinology Journal. - : Bentham Open. ; :5, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Asymmetric dimethylarginine (ADMA) has in some, but not all studies been associated with insulin resistance (IR). We wanted to challenge the hypothesis that plasma ADMA levels are associated with IR in an intervention study using an insulin sensitizing drug. Another aim of the study was to study daytime ADMA variation and if food intake influence ADMA concentration.Methods: Nine patients with diet treated type 2 diabetes were investigated with daytime profiles of ADMA (8 am-5 pm) before and during treatment with rosiglitazone for 8 weeks. A control group matched for age and sex underwent a similar investigation at baseline.Results: After treatment with rosiglitazone, ADMA (0.63- 0.64 mmol/L; p=0.26) and homocysteine (10.3 -10.6 mol/L; p=0.61) concentrations did not change. Postprandial (10 am – 5 pm) ADMA concentrations were 10% higher than fasting morning levels (p=0.006) and this difference was similar for controls and diabetes patients both pre and post treatment with rosiglitazone.Conclusions: Treatment with rosiglitazone aiming to improve insulin sensitivity did not affect ADMA concentration in type 2 diabetes patients. The ADMA daytime variation and the relation to food intake appear to be a novel finding and should be considered in future studies.
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| 35. |
- Codita, Alina, et al.
(författare)
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Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage : A longitudinal study
- 2010
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Ingår i: Behavioural Brain Research. - : Elsevier BV. - 0166-4328 .- 1872-7549. ; 215:1, s. 83-94
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Tidskriftsartikel (refereegranskat)abstract
- Transgenic animals expressing mutant human amyloid precursor protein (APP) are used as models for Alzheimer disease (AD). Ideally, behavioral tests improve the predictive validity of studies on animals by mirroring the functional impact of AD-like neuropathology. Learning and memory studies in APP transgenic models have been difficult to replicate. Standardization of procedures, automatization or improved protocol design can improve reproducibility. Here the IntelliCage, an automated system, was used for behavioral testing of APP female transgenic mice with both the Arctic and Swedish mutations, the tg-ArcSwe model. Protocols covering exploration, operant learning, place learning and extinction of place preference as well as passive avoidance tests were used for longitudinal characterization of behavior. Differences in exploratory activity were significant at four months of age, when plaque-free tg-ArcSwe mice visited less frequently the IntelliCage corners and initially performed fewer visits with licks compared to non-tg animals, inside the new environment. Fourteen months old tg-ArcSwe mice required a longer time to re-habituate to the IntelliCages than non-tg mice. At both ages tg-ArcSwe mice perseverated in place preference extinction test. Fourteen months old tg-ArcSwe mice were impaired in hippocampus-dependent spatial passive avoidance learning. This deficit was found to inversely correlate to calbindin-D28k immunoreactivity in the polymorphic layer of the dentate gyrus. Reduced water intake and body weight were observed in 4 months old tg-ArcSwe animals. The body weight difference increased with age. Thus behavioral and metabolic changes in the tg-ArcSwe APP model were detected using the IntelliCage, a system which provides the opportunity for standardized automated longitudinal behavioral phenotyping.
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| 36. |
- Dalby, Lars, et al.
(författare)
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The status of the Nordic populations of the Mallard (Anas platyrhynchos) in a changing world
- 2013
-
Ingår i: Ornis Fennica. - : Finnish Omithological Soc. - 0030-5685. ; 90:1, s. 2-15
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Tidskriftsartikel (refereegranskat)abstract
- Dabbling ducks (Anas spp.) are importantmigratory quarry species, protected as a shared resource under international legislation. However, there is a lack of sufficient high-quality data on vital demographic rates and long-term trends in numbers to judge the conservation status of many duck populations at the flyway level. In response to reported declines in the North-West European flyway population of theMallard, we compiled available data on this species in the Nordic countries up to 2010. Generally, national breeding numbers showed increasing trends, wintering abundance showed variable trends, and productivitymeasures indicated stable or increasing trends.Major knowledge gaps were identified, namely the size of hunting bags, the influence of the released Mallards and the role of short-stopping in explaining changing patterns of wintering abundance across the North-West European flyway. Numerically the Nordic breeding population appears in “good condition”, and the wintering numbers have been either stable or increasing in the last two decades. The annual number of releases needs to be determined in order to judge the sustainability of the current levels of exploitation. Overall, none of the indicators showed alarming signs for the Mallard population in the Nordic countries when considered in isolation. However, the widespread decline in wintering numbers elsewhere across North-western Europe requires urgent pan-European action.
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| 37. |
- Dalby, Lars, et al.
(författare)
-
The status of the Nordic populations of the Mallard (Anas platyrhynchos) in a changing world
- 2013
-
Ingår i: Ornis Fennica. - : University of Helsinki. - 0030-5685. ; 90:1, s. 2-15
-
Tidskriftsartikel (refereegranskat)abstract
- Dabbling ducks (Anas spp.) are important migratory quarry species, protected as a shared resource under international legislation. However, there is a lack of sufficient high-quality data on vital demographic rates and long-term trends in numbers to judge the conservation status of many duck populations at the flyway level. In response to reported declines in the North-West European flyway population of the Mallard, we compiled available data on this species in the Nordic countries up to 2010. Generally, national breeding numbers showed increasing trends, wintering abundance showed variable trends, and productivity measures indicated stable or increasing trends. Major knowledge gaps were identified, namely the size of hunting bags, the influence of the released Mallards and the role of short-stopping in explaining changing patterns of wintering abundance across the North-West European flyway. Numerically the Nordic breeding population appears in "good condition", and the wintering numbers have been either stable or increasing in the last two decades. The annual number of releases needs to be determined in order to judge the sustainability of the current levels of exploitation. Overall, none of the indicators showed alarming signs for the Mallard population in the Nordic countries when considered in isolation. However, the widespread decline in wintering numbers elsewhere across North-western Europe requires urgent pan-European action.
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| 38. |
- de La Torre, Amanda R, et al.
(författare)
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Insights into conifer giga-genomes
- 2014
-
Ingår i: Plant Physiology. - : American Society of Plant Biologists. - 0032-0889 .- 1532-2548. ; 166:4, s. 1724-1732
-
Tidskriftsartikel (refereegranskat)abstract
- Insights from sequenced genomes of major land plant lineages have advanced research in almost every aspect of plant biology. Until recently, however, assembled genome sequences of gymnosperms have been missing from this picture. Conifers of the pine family (Pinaceae) are a group of gymnosperms that dominate large parts of the world's forests. Despite their ecological and economic importance, conifers seemed long out of reach for complete genome sequencing, due in part to their enormous genome size (20-30 Gb) and the highly repetitive nature of their genomes. Technological advances in genome sequencing and assembly enabled the recent publication of three conifer genomes: white spruce (Picea glauca), Norway spruce (Picea abies), and loblolly pine (Pinus taeda). These genome sequences revealed distinctive features compared with other plant genomes and may represent a window into the past of seed plant genomes. This Update highlights recent advances, remaining challenges, and opportunities in light of the publication of the first conifer and gymnosperm genomes.
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| 39. |
- Dimkovski, Zlate, 1974-, et al.
(författare)
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Functional parameter screening for predicting durability of rolling sliding contacts with different surface finishes
- 2018
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Ingår i: Surface Topography: Metrology and Properties. - Bristol : Institute of Physics Publishing (IOPP). - 2051-672X. ; 6:2
-
Tidskriftsartikel (refereegranskat)abstract
- The reliability and lifetime of machine elements such as gears and rolling bearings depend on their wear and fatigue resistance. In order to screen the wear and surface damage, three finishing processes: (i) brushing, (ii) manganese phosphating and (iii) shot peening were applied on three disc pairs and long-term tested on a twin-disc tribometer. In this paper, the elastic contact of the disc surfaces (measured after only few revolutions) was simulated and a number of functional and roughness parameters were correlated. The functional parameters consisted of subsurface stresses at different depths and a new parameter called 'pressure spikes' factor'. The new parameter is derived from the pressure distribution and takes into account the proximity and magnitude of the pressure spikes. Strong correlations were found among the pressure spikes' factor and surface peak/height parameters. The orthogonal shear stresses and Von Mises stresses at the shallowest depths under the surface have shown the highest correlations but no good correlations were found when the statistics of the whole stress fields was analyzed. The use of the new parameter offers a fast way to screen the durability of the contacting surfaces operating at similar conditions. © 2018 IOP Publishing Ltd.
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Emanuelsson, Pär, et al.
(författare)
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A Comparative Study of Industrial Static Analysis Tools (extended version)
- 2008
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Almost all software contains defects. Some defects are found easily while others are never found, typically because they emerge seldom or not at all. Some defects that emerge relatively often even go unnoticed simply because they are not perceived as errors or are not suffciently severe. Software defects may give rise to several types of errors, ranging from logical/functional ones (the program sometimes computes incorrect values) to runtime errors (the program typically crashes), or resource leaks (performance of the program degrades possibly until the program freezes or crashes). Programs may also contain subtle security vulnerabilities that can be exploited by malicious attackers to gain control over computers. Fixing defects that suddenly emerge can be extremely costly in particular if found at the end of the development cycle, or worse: after deployment. Many simple defects in modern programming languages can be found by modern compilers, e.g. in statically typed languages. But the predominating method for finding defects is testing. Testing has the potential of finding most types of defects, however, testing is costly and no amount of testing will find all defects. Testing is also problematic because it can be applied only to executable code, i.e. rather late in the development process. Alternatives to testing, such as data°ow analysis and formal verification, have been known since the 1970s but have not gained widespread acceptance outside academia|that is, until recently; lately several commercial tools for detecting runtime error conditions at compile time have emerged. The tools build on static analysis and can be used to find runtime errors as well as resource leaks and even some security vulnerabilities statically, i.e. without executing the code. This paper is a survey and comparison of three market leading static analysis tools: PolySpace Verifier, Coverity Prevent and Klocwork K7. The list is by no means exhaustive, and the list of competitors is steadily increasing, but the three tools represent state-of-the-art in the field at the moment. The main objective of this study is (1) to identify significant static analysis functionality provided by the tools, but not addressed in a normal compiler, and (2) to survey the underlying supporting technology. The goal is not to provide a ranking of the tools; nor is it to provide a comprehensive survey of all functionality provided by the tools. Providing such a ranking is problematic for at least two reasons: Static analysis is generally only part of the functionality provided by the tool; for instance, Klocwork K7 supports both refactoring and software metrics which are not supported by the two other tools. Even if restricting attention only to static analysis functionality the tools provide largely non-overlapping functionality. Secondly, even when the tools seemingly provide the same functionality (e.g. detection of dereferencing of null pointers) their solutions are often not comparable; each tool typically finds defects which are not found by any of the other tools. Studying the internals of commercial and proprietary tools is not without problems|in particular, it is impossible to get full information about technical solutions. However, some technical information is publicly available in manuals and white papers; some of the tools also originate from academic tools which have been extensively described in research journals and conference proceedings. While technical solutions may have changed since then, we believe that such information is still largely valid. We have also consulted representatives from all three providers with the purpose to validate our descriptions of the tools. Still it must be pointed out that the descriptions of suggested technical solutions is subject to a certain amount of guessing in some respects. The rest of the report is organized as follows: In Section 2 we define what we mean by the term static analysis and survey some elementary concepts and preconditions; in particular, the trade off between precision and analysis time. Section 3 contains a description of basic principles of static analysis. In Sections 4{6 we survey the static analysis functionality provided by PolySpace Verifier/Desktop, Coverity Prevent and Klocwork K7 focusing in particular on the support for the C and C++ programming languages. Section 7 addresses the complementary issue of programming guidelines such as those of The Motor Software Reliability Association (MISRA). Section 8 contains a qualitative comparison of the three tools summing up their relative merits and shortcomings. The section also surveys several industrial evaluations of the tools over time at Ericsson, in particular involving the products from Coverity and Klocwork. Section 9 contains conclusions.
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| 44. |
- Englund, Hillevi, 1980-, et al.
(författare)
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Sensitive ELISA detection of amyloid-β protofibrils in biological samples
- 2007
-
Ingår i: Journal of Neurochemistry. - : Wiley. - 0022-3042 .- 1471-4159. ; 103:1, s. 334-345
-
Tidskriftsartikel (refereegranskat)abstract
- Amyloid-β (Aβ) protofibrils are known intermediates of the in vitro Aβ aggregation process and the protofibrillogenic Arctic mutation (APPE693G) provides clinical support for a pathogenic role of Aβ protofibrils in Alzheimer's disease (AD). To verify their in vivo relevance and to establish a quantitative Aβ protofibril immunoassay, Aβ conformation dependent monoclonal antibodies were generated. One of these antibodies, mAb158 (IgG2a), was used in a sandwich ELISA to specifically detect picomolar concentrations of Aβ protofibrils without interference from Aβ monomers or the amyloid precursor protein (APP). The specificity and biological significance of this ELISA was demonstrated using cell cultures and transgenic mouse models expressing human APP containing the Swedish mutation (APPKN670/671ML), or the Swedish and Arctic mutation in combination. The mAb158 sandwich ELISA analysis revealed presence of Aβ protofibrils in both cell and animal models, proving that Aβ protofibrils are formed not only in vitro, but also in vivo. Furthermore, elevated Aβ protofibril levels in the Arctic-Swedish samples emphasize the usefulness of the Arctic mutation as a model of enhanced protofibril formation. This assay provides a novel tool for investigating the role of Aβ protofibrils in AD and has the potential of becoming an important diagnostic assay.
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| 45. |
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| 46. |
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| 47. |
- Eriksson, Pär, et al.
(författare)
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Digital consultation in primary healthcare : the effects on access, efficiency and patient safety based on provider experience; a qualitative study
- 2022
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Ingår i: Scandinavian Journal of Primary Health Care. - : Taylor & Francis Group. - 0281-3432 .- 1502-7724. ; 40:4, s. 498-506
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Tidskriftsartikel (refereegranskat)abstract
- Objective The objective of the study was to explore the experiences of healthcare staff working with and being part of the implementation of a digital platform for patient-provider consultation across quality dimensions of access, efficiency, and patient safety. Design The study uses qualitative design to investigate experiences and the views of healthcare professionals. Data collection combined semi-structured individual and focus-group interviews. Content analysis was used to identify categories within the content areas 'access', 'efficiency', and 'patient safety'. Setting The basis for the study was an e-consultation platform introduced in three primary healthcare centres in the County of Kalmar in southeast Sweden in 2019. Results Healthcare staff experienced that the platform offered an open channel for communication with patients in need of frequent contact. This reduced anxiety and therefore the frequency of follow-up appointments. Healthcare staff also noted that the platform offered flexibility in contact benefitting patients with mental health problems. These patients were found to make contact through the platform after closing hours when problems were more acute or intense. However, the risk of digitally illiterate groups being excluded was also noted. Efficiency gains were identified among patients with simple cases which were handled more quickly through the platform. However, low uptake and the experience that the platform did not replace, rather was added on top of other already existing functions and procedures, negatively affected the overall efficiency. Standardized questions in automated medical history-taking contributed to patient safety. Conclusion The findings suggest that text-based e-consultation platforms may bring important quality improvements to primary healthcare service in terms of access, efficiency, and patient safety. Yet, areas where e-consultation does not contribute to quality improvements puts important quality gains at risk.
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| 48. |
-
Exploring Patterns in Information Management : Concepts and Perspectives for Understanding IT-Related Change
- 2003. - 1st
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This book aims at advancing out understanding of information systems and IT-related organisational change. It spurs the development of the field by investigating fundamental concepts, discussing research-based models and frameworks, and reflecting on the field’s evolution and current practices. Intended readers of the book are graduate-level university and business school students, researchers, and reflective practitioners. Of the scholar contributing to the book’s nineteen chapters, many have played important roles in the development of the field in Scandinavia, Continental Europe, the United Kingdom, the United States, and Australia.
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| 49. |
- Falck-Ytter, Terje, et al.
(författare)
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Reduced Orienting to Audiovisual Synchrony in Infancy Predicts Autism Diagnosis at 3 Years of Age
- 2018
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Ingår i: Journal of Child Psychology and Psychiatry. - : Wiley. - 0021-9630 .- 1469-7610. ; 59:8, s. 872-880
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Tidskriftsartikel (refereegranskat)abstract
- Background: Effective multisensory processing develops in infancy and is thought to be important for the perception of unified and multimodal objects and events. Previous research suggests impaired multisensory processing in autism, but its role in the early development of the disorder is yet uncertain. Here, using a prospective longitudinal design, we tested whether reduced visual attention to audiovisual synchrony is an infant marker of later-emerging autism diagnosis.Methods: We studied 10-month-old siblings of children with autism using an eye tracking task previously used in studies of preschoolers. The task assessed the effect of manipulations of audiovisual synchrony on viewing patterns while the infants were observing point light displays of biological motion. We analyzed the gaze data recorded in infancy according to diagnostic status at 3 years of age (DSM-5).Results: Ten-month-old infants who later received an autism diagnosis did not orient to audiovisual synchrony expressed within biological motion. In contrast, both infants at low-risk and high-risk siblings without autism at follow-up had a strong preference for this type of information. No group differences were observed in terms of orienting to upright biological motion.Conclusions: This study suggests that reduced orienting to audiovisual synchrony within biological motion is an early sign of autism. The findings support the view that poor multisensory processing could be an important antecedent marker of this neurodevelopmental condition.
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| 50. |
- Fataftah, Nazeer, et al.
(författare)
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GIGANTEA influences leaf senescence in trees in two different ways
- 2021
-
Ingår i: Plant Physiology. - : Oxford University Press. - 0032-0889 .- 1532-2548. ; 187:4, s. 2435-2450
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Tidskriftsartikel (refereegranskat)abstract
- GIGANTEA (GI) genes have a central role in plant development and influence several processes. Hybrid aspen T89 (Populus tremula x tremuloides) trees with low GI expression engineered through RNAi show severely compromised growth. To study the effect of reduced GI expression on leaf traits with special emphasis on leaf senescence, we grafted GI-RNAi scions onto wild-type rootstocks and successfully restored growth of the scions. The RNAi line had a distorted leaf shape and reduced photosynthesis, probably caused by modulation of phloem or stomatal function, increased starch accumulation, a higher carbon-to-nitrogen ratio, and reduced capacity to withstand moderate light stress. GI-RNAi also induced senescence under long day (LD) and moderate light conditions. Furthermore, the GI-RNAi lines were affected in their capacity to respond to “autumn environmental cues” inducing senescence, a type of leaf senescence that has physiological and biochemical characteristics that differ from those of senescence induced directly by stress under LD conditions. Overexpression of GI delayed senescence under simulated autumn conditions. The two different effects on leaf senescence under LD or simulated autumn conditions were not affected by the expression of FLOWERING LOCUS T. GI expression regulated leaf senescence locally-the phenotype followed the genotype of the branch, independent of its position on the tree-and trees with modified gene expression were affected in a similar way when grown in the field as under controlled conditions. Taken together, GI plays a central role in sensing environmental changes during autumn and determining the appropriate timing for leaf senescence in Populus.
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