| 1. |
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| 2. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
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Tidskriftsartikel (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 3. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 6. |
- Berggren, Åsa, et al.
(författare)
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A sense of place at a fen
- 2014
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Ingår i: Landscapes, Histories and Societies in the Northern European Neolithic. - 9783774938823 ; 4, s. 227-234
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Bokkapitel (refereegranskat)abstract
- This paper will focus on a sense of place in prehistory. The chapter argues for the importance of the sensuous experiences of places, and in this case natural places, in the creation of memory and shared conceptions of place and landscape. Natural places played important roles in the process of creating the societal order in prehistory and in this respect can be considered similar to monuments in defining a sense of place. Here a fen in Malmö in Sweden is discussed, where artefacts were deposited during a period that includes most of the Neolithic period.The topography, the varying vegetation, the water table, as well as the deposited artefacts, created spatial structures that were experienced through the senses by those who moved around this place and performed the acts of deposition. These experiences resulted in a differentiation of this place from the surroundings, which in many cases acted as a ritualization strategy for the acts that took place there. This gave the place a special significance in thelandscape. The fact that this was a recurring practice at the fen, also underlines the historic significance of the place. The sensuous experiences of the acts, the place and the objects also created relations between people, and as such, a social organization. Variations in the social identities that were created at the fen during the course of the Neolithic are discussed in connection to the surrounding society. It seems the fen was mainly used by those that were not a part of the competition for the highest status in society, i.e. the elite, but rather a social stratum of society less likely to have, and dispose of, prestige objects. This part of society did not consist of a grey mass of people but rather a complex web of social relations.
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| 7. |
- Hydén, Susan, et al.
(författare)
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Fragments of life and death : the biography of grinding and polishing stones found in long barrows at the Almhov burial site
- 2014
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Ingår i: Landscapes, histories and societies in the Northern European Neolithic. - 9783774938823 ; Frühe Monumentalität und soziale Differenzierung 4, s. 247-260
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The burial and gathering site Almhov was discovered as a result of large-scale archaeological excavations in southern Sweden revealing the remains of five long barrows, two dolmens and a large number of pits, rich in finds. Given the multitude of activities performed at the site including, for example, monument-building, pit-digging, burying, feasting and axe-manufacturing, the site can serve as an example ofthe complexity of large Early Neolithic gathering places. The activities, as well as the physical monuments and pits, can be interpreted as an expression of how Early Neolithic man made sense of the changing world brought about by the Neolithization. Different perspectives as well as archaeological remains of various kinds offer different narratives of this on-going process. Artefacts interpreted as polishing and grinding stones were by far the most common type of ground stone artefacts found at Almhov, and the interesting contexts in which they were discovered,as well as their sheer number, poses a variety of questions about their presence at Almhov. How can we, for example, make these artefacts tell us something about the people in the area and the Neolithic way of life? This article focuses on the grinding and polishing stones found in two of the long barrows on Almhov, and uses them as the basis of a case study of how a biographical approach can be utilized as a method of categorizing and interpreting ground stone artefacts. Why, for example, were pieces of grinding stones placed in connection with the façade of one of the long barrows? Why were grinding stones, broken in half, put into graves? This paper suggests that the tools represented the novelty of making monuments and that putting them together with the dead could have been a way of mediating new practices with reference to the past.
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| 8. |
- Jennbert, Kristina, et al.
(författare)
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The seashore – beyond monumentality : The case of Pitted Ware coastal sites in southern Sweden
- 2014
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Ingår i: Landscapes, histories and societies in the Northern European Neolithic. - 9783774938823 ; 4, s. 235-243
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Bokkapitel (refereegranskat)abstract
- What is the significance of a place at the seashore? What kind of a sense of place does a place by the seashore constitute in the absence of any kind of monumental structures? Today, it is obvious within the archaeological domain that archaeological material culture is not only functional, but also acts as a metaphor for people’s self-perception. In this article, my assumption is that the different archaeo- logical cultural groups in southern Sweden during the Neolithic represent different social identities and lifestyles. As a result of this, both rival and syncretic cultural encounters existed in the past. Different cultural identities are dependent on scale, very local or regional in Scandinavia, as in other parts of Europe. Undoubtedly, processes of creoli- zation occurred between groups of people and can perhaps be understood in terms of processes of domination and competition. The character of the archaeological material culture indicates a highly power-structured mentality in the Neolithic. In the case study outlined here, the location of the Pitted Ware sites at Jonstorp in the north-western part of Scania in southern Sweden far away from the monumental landscape further south in Scania is the starting point for a discussion of Neolithic coastal sites and seashores.
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| 9. |
- Jones, Samantha E., et al.
(författare)
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Lake and crannog : A 2500-year palaeoenvironmental record of continuity and change in NE Scotland
- 2022
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 285
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Tidskriftsartikel (refereegranskat)abstract
- Wetland environments have been important resources for human habitation since prehistoric times and in parts of northern Europe these have witnessed the construction of artificial islet settlements, known as ‘crannogs’ in Scotland and Ireland. This paper presents a high-resolution multi-proxy palaeoenvironmental study from the Loch of Leys, Aberdeenshire, Scotland, the site of a recently excavated crannog that provides a chronological context for its inhabitation. The combined datasets demonstrate that the first occupation from AD 20–210 coincided not only with a transitional phase from lake to wetland (mire) but also with the timing of the first major Roman campaigns in northeast Scotland. Techniques including microfossil analysis, geochemistry, IR-spectroscopy and physical properties integrated with archaeological and historical records have helped to better define both natural changes that took place in the wetland environment and human activity (agriculture, fires, metal working) spanning the Roman Iron Age through to the present. This has allowed a better understanding of the responses of existing Iron Age communities to Roman military activity (e.g. through continuity or change in land use) as well as the resources exploited in frontier zones during the Roman and post Roman eras. This has wider significance not just for Scotland but also for other parts of Europe that had similar frontiers and conflict zones during the Roman period.
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| 10. |
- Kepp, Kasper P., et al.
(författare)
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Panel stacking is a threat to consensus statement validity
- 2024
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Ingår i: Journal of Clinical Epidemiology. - : Elsevier. - 0895-4356 .- 1878-5921. ; 173
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Tidskriftsartikel (refereegranskat)abstract
- Consensus statements can be very influential in medicine and public health. Some of these statements use systematic evidence synthesis but others fail on this front. Many consensus statements use panels of experts to deduce perceived consensus through Delphi processes. We argue that stacking of panel members toward one particular position or narrative is a major threat, especially in absence of systematic evidence review. Stacking may involve financial conflicts of interest, but nonfinancial conflicts of strong advocacy can also cause major bias. Given their emerging importance, we describe here how such consensus statements may be misleading, by analyzing in depth a recent high-impact Delphi consensus statement on COVID-19 recommendations as a case example. We demonstrate that many of the selected panel members and at least 35% of the core panel members had advocated toward COVID-19 elimination (Zero-COVID) during the pandemic and were leading members of aggressive advocacy groups. These advocacy conflicts were not declared in the Delphi consensus publication, with rare exceptions. Therefore, we propose that consensus statements should always require rigorous evidence synthesis and maximal transparency on potential biases toward advocacy or lobbyist groups to be valid. While advocacy can have many important functions, its biased impact on consensus panels should be carefully avoided.
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| 11. |
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| 12. |
- Levin, Johannes, et al.
(författare)
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α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
- 2024
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Ingår i: Alzheimer's and Dementia. - 1552-5260. ; 20:6, s. 4351-4365
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known neuropathology, we investigated the timing of occurrence and prevalence of SAA positive reactivity in ADAD in vivo. RESULTS: No asymptomatic participant and only 11% (3/27) of the symptomatic patients tested SAA positive. Neuropathology revealed LBP in 10/12 cases, primarily affecting the amygdala or the olfactory areas. In the latter group, only the individual with diffuse LBP reaching the neocortex showed α-synuclein seeding activity in CSF in vivo. DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity. Highlights: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-synuclein RT-QuIC has low sensitivity for focal, low-burden LBP.
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| 13. |
- Matthews, Nathaniel, et al.
(författare)
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Elevating the role of water resilience in food system dialogues
- 2022
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Ingår i: Water Security. - : Elsevier B.V.. - 2468-3124. ; 17
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Tidskriftsartikel (refereegranskat)abstract
- Ensuring resilient food systems and sustainable healthy diets for all requires much higher water use, however, water resources are finite, geographically dispersed, volatile under climate change, and required for other vital functions including ecosystems and the services they provide. Good governance for resilient water resources is a necessary precursor to deciding on solutions, sourcing finance, and delivering infrastructure. Six attributes that together provide a foundation for good governance to reduce future water risks to food systems are proposed. These attributes dovetail in their dual focus on incorporating adaptive learning and new knowledge, and adopting the types of governance systems required for water resilient food systems. The attributes are also founded in the need to greater recognise the role natural, healthy ecosystems play in food systems. The attributes are listed below and are grounded in scientific evidence and the diverse collective experience and expertise of stakeholders working across the science-policy interface: Adopting interconnected systems thinking that embraces the complexity of how we produce, distribute, and add value to food including harnessing the experience and expertise of stakeholders s; adopting multi-level inclusive governance and supporting inclusive participation; enabling continual innovation, new knowledge and learning, and information dissemination; incorporating diversity and redundancy for resilience to shocks; ensuring system preparedness to shocks; and planning for the long term. This will require food and water systems to pro-actively work together toward a socially and environmentally just space that considers the water and food needs of people, the ecosystems that underpin our food systems, and broader energy and equity concerns.
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| 14. |
- Morez, Adeline, et al.
(författare)
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Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK
- 2023
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 19:4
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Tidskriftsartikel (refereegranskat)abstract
- There are longstanding questions about the origins and ancestry of the Picts of early medieval Scotland (ca. 300–900 CE), prompted in part by exotic medieval origin myths, their enigmatic symbols and inscriptions, and the meagre textual evidence. The Picts, first mentioned in the late 3rd century CE resisted the Romans and went on to form a powerful kingdom that ruled over a large territory in northern Britain. In the 9th and 10th centuries Gaelic language, culture and identity became dominant, transforming the Pictish realm into Alba, the precursor to the medieval kingdom of Scotland. To date, no comprehensive analysis of Pictish genomes has been published, and questions about their biological relationships to other cultural groups living in Britain remain unanswered. Here we present two high-quality Pictish genomes (2.4 and 16.5X coverage) from central and northern Scotland dated from the 5th-7th century which we impute and co-analyse with >8,300 previously published ancient and modern genomes. Using allele frequency and haplotype-based approaches, we can firmly place the genomes within the Iron Age gene pool in Britain and demonstrate regional biological affinity. We also demonstrate the presence of population structure within Pictish groups, with Orcadian Picts being genetically distinct from their mainland contemporaries. When investigating Identity-By-Descent (IBD) with present-day genomes, we observe broad affinities between the mainland Pictish genomes and the present-day people living in western Scotland, Wales, Northern Ireland and Northumbria, but less with the rest of England, the Orkney islands and eastern Scotland—where the political centres of Pictland were located. The pre-Viking Age Orcadian Picts evidence a high degree of IBD sharing across modern Scotland, Wales, Northern Ireland, and the Orkney islands, demonstrating substantial genetic continuity in Orkney for the last ~2,000 years. Analysis of mitochondrial DNA diversity at the Pictish cemetery of Lundin Links (n = 7) reveals absence of direct common female ancestors, with implications for broader social organisation. Overall, our study provides novel insights into the genetic affinities and population structure of the Picts and direct relationships between ancient and present-day groups of the UK.
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| 15. |
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| 16. |
- Noble, Gordon, et al.
(författare)
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Dunnicaer, Aberdeenshire, Scotland : a Roman Iron Age promontory fort beyond the frontier
- 2020
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Ingår i: The Archaeological Journal. - : Taylor & Francis. - 0066-5983 .- 2373-2288. ; 177:2, s. 256-338
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Tidskriftsartikel (refereegranskat)abstract
- Dunnicaer, Aberdeenshire, a now isolated sea stack, is the findspot of five Pictish symbol stones discovered in the nineteenth century. Excavations from 2015 to 2017 have revealed a Roman Iron Age promontory fort, providing insights into the development of fortified settlement in north-east Scotland, with fortified sites being a key feature of first millennium AD elite practice in this region. The presence of rare and unusual finds indicates contact with the Roman world to the south and changes in the character of settlement as evidenced at Dunnicaer indicate broader transitions in the later Roman Iron Age native society. The archaeological sequence at Dunnicaer sheds new light on the adoption of non-roundhouse styles of architecture in first millennium AD Scotland and provides important evidence for the dating of the Pictish symbol tradition. A consideration of the impacts of coastal erosion on promontories of this nature suggests these are amongst the most threatened archaeological sites.
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| 17. |
- Olausson, Deborah, et al.
(författare)
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The "Mental" in Monumental : Battle Axe Culture in megalithic tombs in southern Sweden
- 2014
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Ingår i: Landscapes, histories and societies in the Northern European Neolithic. - 9783774938823 ; , s. 261-274
-
Bokkapitel (refereegranskat)abstract
- It is reasonable to consider that those who arranged the material accoutrements of mortuary practices, i.e. the burial, were making a more or less conscious statement about cultural identity. At least we archaeologists usually assume this to be so. An interesting case can be found in the mortuary practices ascribed to the Battle Axe culture from the later Middle Neolithic1 (2800–2350 cal BC) in southern Scandinavia. When we look at burials which we archaeologists ascribe to the Battle Axe culture we can identify several variations: flexed inhumation of a single individual in a stone-lined pit (referred to as flat-earth burial), flexed inhuma- tion of multiple individuals in a stone-lined pit, and cremation burial. Additionally, we often interpret the presence of Battle Axe artefacts and/or radi- ocarbon dates falling within this period in mega- lithic tombs as evidence that burial in such tombs was also part of the Battle Axe mortuary repertoire.
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| 18. |
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| 19. |
- Rockström, Johan, et al.
(författare)
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Sustainable intensification of agriculture for human prosperity and global sustainability
- 2017
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 46:1, s. 4-17
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Tidskriftsartikel (refereegranskat)abstract
- There is an ongoing debate on what constitutes sustainable intensification of agriculture (SIA). In this paper, we propose that a paradigm for sustainable intensification can be defined and translated into an operational framework for agricultural development. We argue that this paradigm must now be defined-at all scales-in the context of rapidly rising global environmental changes in the Anthropocene, while focusing on eradicating poverty and hunger and contributing to human wellbeing. The criteria and approach we propose, for a paradigm shift towards sustainable intensification of agriculture, integrates the dual and interdependent goals of using sustainable practices to meet rising human needs while contributing to resilience and sustainability of landscapes, the biosphere, and the Earth system. Both of these, in turn, are required to sustain the future viability of agriculture. This paradigm shift aims at repositioning world agriculture from its current role as the world's single largest driver of global environmental change, to becoming a key contributor of a global transition to a sustainable world within a safe operating space on Earth.
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| 20. |
- Sanchez-Quinto, Federico, et al.
(författare)
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Megalithic tombs in western and northern Neolithic Europe were linked to a kindred society
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:19, s. 9469-9474
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Tidskriftsartikel (refereegranskat)abstract
- Paleogenomic and archaeological studies show that Neolithic lifeways spread from the Fertile Crescent into Europe around 9000 BCE, reaching northwestern Europe by 4000 BCE. Starting around 4500 BCE, a new phenomenon of constructing megalithic monuments, particularly for funerary practices, emerged along the Atlantic facade. While it has been suggested that the emergence of megaliths was associated with the territories of farming communities, the origin and social structure of the groups that erected them has remained largely unknown. We generated genome sequence data from human remains, corresponding to 24 individuals from five megalithic burial sites, encompassing the widespread tradition of megalithic construction in northern and western Europe, and analyzed our results in relation to the existing European paleogenomic data. The various individuals buried in megaliths show genetic affinities with local farming groups within their different chronological contexts. Individuals buried in megaliths display (past) admixture with local hunter-gatherers, similar to that seen in other Neolithic individuals in Europe. In relation to the tomb populations, we find significantly more males than females buried in the megaliths of the British Isles. The genetic data show close kin relationships among the individuals buried within the megaliths, and for the Irish megaliths, we found a kin relation between individuals buried in different megaliths. We also see paternal continuity through time, including the same Y-chromosome haplotypes reoccurring. These observations suggest that the investigated funerary monuments were associated with patrilineal kindred groups. Our genomic investigation provides insight into the people associated with this long-standing megalith funerary tradition, including their social dynamics.
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| 21. |
- Turcu, I. C. E., et al.
(författare)
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HIGH FIELD PHYSICS AND QED EXPERIMENTS AT ELI-NP
- 2016
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Ingår i: Romanian Reports on Physics. - 1221-1451 .- 1841-8759. ; 68, s. S145-S231
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Tidskriftsartikel (refereegranskat)abstract
- ELI-NP facility will enable for the first time the use of two 10 PW laser beams for quantum electrodynamics (QED) experiments. The first beam will accelerate electrons to relativistic energies. The second beam will subject relativistic electrons to the strong electromagnetic field generating QED processes: intense gamma ray radiation and electron-positron pair formation. The laser beams will be focused to intensities above 10(21) Wcm(-2) and reaching 10(22)-10(23) Wcm(-2) for the first time. We propose to use this capability to investigate new physical phenomena at the interfaces of plasma, nuclear and particle physics at ELI-NP. This High Power Laser System Technical Design Report (HPLS-TDR2) presents the experimental area E6 at ELI-NP for investigating high field physics and quantum electrodynamics and the production of electron-positron-pairs and of energetic gamma-rays. The scientific community submitted 12 commissioning runs for E6 interaction chamber with two 10 PW laser beams and one proposal for the CETAL interaction chamber with 1 PW laser. The proposals are representative of the international high field physics community being written by 48 authors from 14 European and US organizations. The proposals are classified according to the science area investigated into: Radiation Reaction Physics: Classical and Quantum; Compton and Thomson Scattering Physics: Linear and Non Linear Regimes; QED in Vacuum; Atoms in Extreme Fields. Two pump-probe colliding 10 PW laser beams are proposed for the E6 interaction chamber. The focused pump laser beam accelerates the electrons to relativistic energies. The accelerated electron bunches interact with the very high electro-magnetic field of the focused probe laser beam. We propose two main types of experiments with: (a) gas targets in which the pump laser-beam is focused by a long focal length mirror and drives a wakefield in which the electron bunch is accelerated to multi-GeV energies and then exposed to the EM field of the probe laser which is tightly focused; (b) solid targets in which both the pump and probe laser beams are focused on the solid target, one accelerating the electrons in the solid and the other, delayed, providing the high electric field to which the relativistic electrons are subjected. We propose four main focusing configurations for the pump and probe laser beams, two for each type of target: counter-propagating 10 PW focused laser beams and the two 10 PW laser beams focused in the same direction. For solid targets we propose an additional configuration with plasma-mirror on the pump laser beam: the plasma mirror placed between the focusing mirror and target. It is proposed that the 10 PW laser beams will have polarization control and focus control by means of adaptive optics. Initially only one 10 PW may have polarization control and adaptive optics. In order to accommodate the two laser beams and diagnostics the proposed interaction chamber is quasi-octagonal with a diameter of 4.5 m. A large electron-spectrometer is proposed for multi-GeV electrons. Other diagnostics are requested for: gamma-rays, electrons and positrons, protons and ions, plasma characterization, transmitted and reflected laser beam. Targets will be provided by the ELI-NP Target Laboratory or purchased. The E6 experiments and diagnostics will benefit from the ELI-NP Electronics Laboratory, the Workshop and the Optics Laboratory. In order to ensure radiation-protection, a large beam-dump is planned for both multi-GeV electrons and multi-100 MeV protons.
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