| 1. |
- Metcalfe, N. B., et al.
(author)
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Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species
- 2023
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In: Bioessays. - 0265-9247. ; 45:6
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Journal article (peer-reviewed)abstract
- Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals.
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| 2. |
- Sorensen, S. L., et al.
(author)
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Femtosecond pump-probe photoelectron spectroscopy of predissociative Rydberg states in acetylene
- 2000
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In: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 112:18, s. 8038-8042
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Journal article (peer-reviewed)abstract
- We employ a pump-probe approach to molecular photoionization to study fast dissociation of Rydberg states in acetylene. By using time-resolved photoelectron spectroscopy to study the electronic state of the resulting ions we are able to monitor the system continuously during dissociation or rearrangement. We find that the predissociative lifetime for the 3R‴ (v′2 = 1) Rydberg state is about 150 fs. We demonstrate a powerful new technique using time-correlated femtosecond harmonic generation and laser light pulses to study the time evolution of ultrafast dynamic processes in molecules.
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| 5. |
- Sorensen, SL, et al.
(author)
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Femtosecond pump-probe photoelectron spectroscopy of predissociative Rydberg states in acetylene
- 2000
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In: JOURNAL OF CHEMICAL PHYSICS. - : AMER INST PHYSICS. - 0021-9606. ; 112:18, s. 8038-8042 Language: English
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Journal article (peer-reviewed)abstract
- We employ a pump-probe approach to molecular photoionization to study fast dissociation of Rydberg states in acetylene. By using time-resolved photoelectron spectroscopy to study the electronic state of the resulting ions we are able to monitor the system
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| 7. |
- Eriksson, LarsOlov, et al.
(author)
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Kapitlet Texten
- 2021
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In: Gud och det utvalda folket. Inledning till Gamla testamentet / LarsOlov Eriksson och Åke Viberg [red.].. - Stockholm : Verbum. - 9789152638989 ; , s. 17-29
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Book chapter (peer-reviewed)abstract
- Kapitlet behandlar Gamla testamentets text, skrivmaterial, kanon och kanonbildning, bibelöversättnin. Den har exkurser med rubrikerna Qumrantexterna, Septuaginta, textkritik i praktiken och bibelöversättning i ett svenskt perspektiv.
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| 8. |
- Fallani, M, et al.
(author)
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Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres
- 2011
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In: Microbiology (Reading, England). - : Microbiology Society. - 1465-2080 .- 1350-0872. ; 157:Pt 5, s. 1385-1392
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Journal article (peer-reviewed)abstract
- Although it is well established that early infant feeding has a major influence on the establishment of the gut microbiota, very little is understood about how the introduction of first solid food influences the colonization process. This study aimed to determine the impact of weaning on the faecal microbiota composition of infants from five European countries (Sweden, Scotland, Germany, Italy and Spain) which have different lifestyle characteristics and infant feeding practices. Faecal samples were collected from 605 infants approximately 4 weeks after the introduction of first solid foods and the results were compared with the same infants before weaning (6 weeks of age) to investigate the association with determining factors such as geographical origin, mode of delivery, previous feeding method and age of weaning. Samples were analysed by fluorescence in situ hybridization and flow cytometry using a panel of 10 rRNA targeted group- and species-specific oligonucleotide probes. The genus Bifidobacterium (36.5 % average proportion of total detectable bacteria), Clostridium coccoides group (14 %) and Bacteroides (13.6 %) were predominant after weaning. Similar to pre-weaning, northern European countries were associated with a higher proportion of bifidobacteria in the infant gut microbiota while higher levels of Bacteroides and lactobacilli characterized southern European countries. As before weaning, the initial feeding method influenced the Clostridium leptum group and Clostridium difficile+Clostridium perfringens species, and bifidobacteria still dominated the faeces of initially breast-fed infants. Formula-fed babies presented significantly higher proportions of Bacteroides and the C. coccoides group. The mode of birth influenced changes in the proportions of bacteroides and atopobium. Although there were significant differences in the mean weaning age between countries, this was not related to the populations of bifidobacteria or bacteroides. Thus, although the faecal microbiota of infants after first complementary foods was different to that before weaning commenced, many of the initial influences on microbiota composition were still evident.
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| 10. |
- Li, Z. S, et al.
(author)
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Radiative properties of neutral germanium obtained from excited-state lifetime and branching-ratio measurements and comparison with theoretical calculations
- 1999
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In: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 60:1, s. 198-208
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Journal article (peer-reviewed)abstract
- Using time-resolved UV laser-induced fluorescence from a laser-produced plasma, natural radiative lifetimes have been measured for 21 levels of Ge I belonging to the odd-parity 4p4d, 4p5d, and 4p6s configurations. Stimulated Brillouin scattering in water has allowed us to compress Nd:YAG laser pulses pumping a dye laser (where YAG denotes yttrium aluminum garnet), thus yielding 1-ns tunable laser pulses to enable accurate measurements of short lifetimes. Branching ratios of Ge I have been measured by inductively coupled plasma emission spectrometry, the intensity calibration being performed by means of Ar lines emitted by a hollow-cathode lamp. The experimental lifetimes and branching ratios have been combined in order to provide a set of accurate transition probabilities for the 4p-5s and 4p-4d transitions. A relativistic Hartree-Fock; calculation, taking configuration-interaction and polarization effects into account, has been combined with a least-squares optimization procedure of the Slater and spin-orbit integrals in order to test the ability of this approach to correctly predict radiative properties of the group-IV elements. Good agreement between experimental and theoretical transition probability values has been achieved for most of the transitions considered.
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| 15. |
- S. Zamith, V. Blanchet, B. Girard, J. Norin, J. Mauritsson, A. l'Huillier, J. Andersson, S. L. Sorensen, I. Hjelte, O. Björneholm and D. Gauyacq
(author)
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The predissociation of highly excited states in acetylene by time-resolved photoelectron spectroscopy
- 2003
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In: Journal of Chemical Physics. ; :119, s. 3763-
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Journal article (peer-reviewed)
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| 26. |
- Carlsson, G., et al.
(author)
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A scoping review of public building accessibility
- 2022
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In: Disability and Health Journal. - : Elsevier BV. - 1936-6574. ; 15:2
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Research review (peer-reviewed)abstract
- Background: The built environment needs to be designed so that all people can participate in the activities they want and need to do. Yet, accessibility is difficult to put into practice, and accessibility issues tend to be overlooked in the building and planning processes. Objectives: The aim of this scoping review was to summarize the research front in the area of accessibility to public buildings. Specific aims were to identify knowledge gaps, to identify access activities in relation to environmental features and to link to predominant activities in terms of the International Classification of Functioning, Disability and Health (ICF). Methods: A literature search was performed in PubMed, PsycINFO, Inspec, Embase and Cochrane databases. Articles in English based on original empirical studies investigating accessibility of public buildings for adults aged ≥18 years with functional limitations were considered. Results: Of the 40 articles included, ten involved study participants, while 30 only examined buildings using instruments to assess accessibility. In addition, the psychometric properties were only tested for a few of them. All articles concerned mobility and several visual limitations, while few addressed cognitive or hearing limitations. Ten main access activities were identified, from using parking/drop-off area to exiting building. Conclusions: By using the ICF and theoretically relating the accessibility problems to activities, the results revealed that there are large knowledge gaps about accessibility to public buildings for older people and people with functional limitations and that there is a need for more methodological considerations in this area of research.
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| 27. |
- Cheng, Liqin, et al.
(author)
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- 2024
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In: Gut microbes. - : Taylor & Francis. - 1949-0976 .- 1949-0984. ; 16:1
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Journal article (peer-reviewed)abstract
- Multidrug-resistant microorganisms have become a major public health concern around the world. The gut microbiome is a gold mine for bioactive compounds that protect the human body from pathogens. We used a multi-omics approach that integrated whole-genome sequencing (WGS) of 74 commensal gut microbiome isolates with metabolome analysis to discover their metabolic interaction with Salmonella and other antibiotic-resistant pathogens. We evaluated differences in the functional potential of these selected isolates based on WGS annotation profiles. Furthermore, the top altered metabolites in co-culture supernatants of selected commensal gut microbiome isolates were identified including a series of dipeptides and examined for their ability to prevent the growth of various antibiotic-resistant bacteria. Our results provide compelling evidence that the gut microbiome produces metabolites, including the compound class of dipeptides that can potentially be applied for anti-infection medication, especially against antibiotic-resistant pathogens. Our established pipeline for the discovery and validation of bioactive metabolites from the gut microbiome as novel candidates for multidrug-resistant infections represents a new avenue for the discovery of antimicrobial lead structures.
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| 30. |
- Engholm, M., et al.
(author)
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A structural investigation of a synthesized precursor for optical fiber applications : the heterobimetallic ErNb2(OPri)(13)
- 2006
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In: Optical materials (Amsterdam). - : Elsevier BV. - 0925-3467 .- 1873-1252. ; 29:4, s. 386-391
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Journal article (peer-reviewed)abstract
- A structural investigation of a synthesized precursor in a silica glass matrix is performed. Silica soot samples are doped with the heterobimetallic precursor ErNb2(OPri)13 by using a conventional solution doping technique and heat treatments to different temperatures. The precursor has also been introduced into a silica fiber preform by using the modified chemical vapor deposition technique. Analyses are made by using ultraviolet–visible–near infrared absorption spectroscopy, scanning electron microscopy, energy dispersive spectroscopy and powder X-ray diffraction. It is concluded that an immiscible system of ErNbO4 crystallites and Nb2O5 is formed in the silica soot samples at high temperatures. Colloidal particles of ErNbO4 are also formed in the silica glass fiber preform showing interesting features.
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| 33. |
- Garcia-Ruiz, A., et al.
(author)
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Hermetic all-fiber phase modulators using Joule heating in carbon-coated fibers
- 2018
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In: Optics InfoBase Conference Papers. - Washington, D.C. : OSA - The Optical Society. - 9781557528209
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Conference paper (peer-reviewed)abstract
- Certain applications of fiber sensors (e.g. avionics, oil industry) imply extreme operating conditions spurring the development of hermetic all-fiber devices. We present a hermetic all-fiber phase modulator based on Joule heating in a carbon-coated fiber.
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| 40. |
- Gustafsson, Nina M. S., et al.
(author)
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Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
- 2018
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9
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Journal article (peer-reviewed)abstract
- The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anticancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into ionizing radiation (IR)-induced nuclear foci in an MRN-ATM-gamma H2AX-MDC1-dependent manner and co-localizes with DNA damage and HR repair proteins. PFKFB3 relocalization is critical for recruitment of HR proteins, HR activity, and cell survival upon IR. We develop KAN0438757, a small molecule inhibitor that potently targets PFKFB3. Pharmacological PFKFB3 inhibition impairs recruitment of ribonucleotide reductase M2 and deoxynucleotide incorporation upon DNA repair, and reduces dNTP levels. Importantly, KAN0438757 induces radiosensitization in transformed cells while leaving non-transformed cells unaffected. In summary, we identify a key role for PFKFB3 enzymatic activity in HR repair and present KAN0438757, a selective PFKFB3 inhibitor that could potentially be used as a strategy for the treatment of cancer.
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| 41. |
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| 42. |
- Hergott, JF, et al.
(author)
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XUV interferometry using high-order harmonics: Application to plasma diagnostics
- 2001
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In: Laser and Particle Beams. - 0263-0346. ; 19:1, s. 35-40
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Journal article (peer-reviewed)abstract
- In this paper, we present and compare the two different XUV interferometric techniques using high-order harmonics that have been developed so far. The first scheme is based on the interference between two spatially separated phase-locked harmonic sources while the second uses two temporally separated harmonic sources. These techniques have been applied to plasma diagnostics in feasibility experiments where electron densities up to a few 1020 e[minus sign/cm3 have been measured with a temporal resolution of 200 fs. We present the main characteristics of each technique and discuss their respective potentials and limitations.
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