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- Norlund, Lena, et al.
(författare)
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Patientnära analyser används inte enhetligt i primärvården
- 2014
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Ingår i: Läkartidningen. - : Läkartidningen Förlag AB. - 0023-7205 .- 1652-7518. ; 111:24, s. 1054-1056
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Tidskriftsartikel (refereegranskat)abstract
- I en enkätstudie har omfattningen av den patientnära laboratorieverksamheten i dagens svenska primärvård kartlagts. De fem vanligaste analyserna var urintestremsa, P-glukos, P-CRP och snabbtest för grupp A-streptokocker samt B-hemoglobin.Jämfört med data som publicerades för 20 år sedan har volymen av patientnära analyser ökat, framför allt på grund av den nya analysen CRP.Även graden av ackreditering och kvalitetssäkring i dagens patientnära laborerande studerades; det framgick att ackrediteringsgraden varierar mellan 0 och 100 procent i olika regioner.
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| 2. |
- Norlund, Lena, et al.
(författare)
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A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
- 1997
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 77:2, s. 51-248
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Tidskriftsartikel (refereegranskat)abstract
- Endothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for development of premature myocardial infarction (MI). The C/T dimorphism predicts an Ala455 to Val replacement in the sixth EGF-like domain of TM. The dimorphism was investigated in 97 MI survivors and 159 healthy controls. The C allele was significantly more frequent among patients than controls (p = 0.035). The allele frequency for the C allele was 0.82 in the patients and 0.72 in the control group. The plasma concentration of TM was investigated among healthy controls but was not related to the C/T dimorphism. In conclusion, the association of the C allele with premature MI, suggests that the TM gene and the C/T dimorphism may be aetiological factors involved in the pathogenesis of MI. Possibly, the Ala455 to Val replacement may affect the function of the TM molecule and the activation of the protein C anticoagulant pathway.
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| 3. |
- Norlund, Lena, et al.
(författare)
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A novel thrombomodulin gene mutation in a patient suffering from sagittal sinus thrombosis
- 1997
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 78:4, s. 1164-1166
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Tidskriftsartikel (refereegranskat)abstract
- Thrombomodulin is an endothelial cell membrane glycoprotein that promotes protein C activation. It has been clearly demonstrated that the anticoagulant functions of the protein C system are important in the prevention of thromboembolic disease. Patients with protein C or protein S deficiency and/or resistance to activated protein C (APC resistance) are at higher risk for developing thromboembolic disease. The first mutation in the thrombomodulin gene was discovered in an American patient suffering from pulmonary embolism at the age of 45 (Ohlin and Marlar 1995). Here we report a case of sagittal sinus thrombosis in a 42-year-old Swedish woman. She was found to carry a heterozygous point mutation changing G127 to A, predicting an Ala25 to a Thr change in the mature thrombomodulin protein. This mutation was also found in her 16-year-old daughter, who so far has not suffered from any thrombotic events. The patient had no other detectable prothrombotic genetic defects associated with the coagulation system. This case supports the hypothesis of an association between mutations in the thrombomodulin gene and venous thrombosis.
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| 7. |
- Norlund, Lena, et al.
(författare)
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The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C
- 1998
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Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621. ; 36:3, s. 175-178
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Tidskriftsartikel (refereegranskat)abstract
- One of the main determinants of plasma homocysteine in healthy subjects is serum creatinine. In the present study, we therefore investigated the relation between plasma homocysteine concentration, serum creatinine and a new marker for glomerular filtration rate, plasma cystatin C concentration. Cystatin C reflects the glomerular filtration better than serum creatinine and is not related to the muscle mass and formation of creatinine. The study group consisted of 255 healthy subjects from a well-defined area in the southern part of Sweden. The concentration of plasma homocysteine was increased in men compared to women. This difference disappeared when men and women were stratified by serum creatinine values. Statistically significant correlations were noted between plasma homocysteine and age, plasma cystatin C and serum creatinine. It is shown that plasma homocysteine is not only correlated to serum creatinine as a result of renal function but also as a result of the relationship between homocysteine production and creatine-creatinine synthesis. Using linear regression we were able to show that plasma cystatin C had a higher explanatory value than age. Serum creatinine showed a lower explanatory power than age. The findings in the present study might suggest that the increase of plasma homocysteine concentration with age could be partly due to the deterioration of renal function.
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