| 1. |
- Cardell, Kristina, 1964-, et al.
(författare)
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Intradermal hepatitis B vaccination in health care workers. Response rate and experiences from vaccination in clinical practise
- 1999
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Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 31:2, s. 197-200
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Tidskriftsartikel (refereegranskat)abstract
- Health care workers at risk for hepatitis B virus infection are recommended for vaccination. Low-dose intradermal (i.d.) administration of vaccine has been suggested as a less expensive alternative to intramuscular (i.m.) inoculation. To evaluate the i.d. vaccination route, health care workers were included in a prospective study. The subjects were vaccinated with 0.1 ml (= 2 microg) recombinant vaccine (Engerix B, SmithKline Beecham) i.d. at 0, 1 and 6 months. Two months after the third vaccination, measurement of the anti-HBs level was conducted. An anti-HBs level > or =10 IU/l was considered protective. Those with an anti-HBs level <10 IU/l were given a fourth dose with new serological control after another 2 months. The results are based on the 1406 subjects that it was possible to evaluate. The seroconversion rate to protective anti-HBs level after 3 doses was 68% and after 3 or 4 doses 89%. Factors associated with a lower response rate were increasing age (p<0.05) and smoking (p<0.001). Sex or body mass index had no influence on the results. Vaccination technique seems to be of utmost importance when the i.d. route is used. Well instructed and experienced nurses are required and quality control with follow-up of overall seroconversion rate within each centre is needed.
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| 2. |
- Dannetun, E., et al.
(författare)
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Influenza vaccine coverage and reasons for non-vaccination in a sample of people above 65 years of age, in Sweden, 1998-2000
- 2003
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Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 35:6-7, s. 389-393
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Tidskriftsartikel (refereegranskat)abstract
- Influenza vaccination for the elderly has been shown to be effective. The Swedish national recommendations are that people over 65 y, and especially those with chronic cardiac and/or pulmonary disease, should be immunized annually. However, implementation of such programmes has often been far from successful. The aims of this study were to estimate vaccine coverage and especially reasons for not being vaccinated in a group of elderly people who were all clearly included in the national recommendations. The study investigated people over the age of 65 y who lived in special apartments, 'service homes', connected to the community care for the elderly in the municipality of Linköping, Sweden. The data were collected from the middle of May to the middle of July during 3 years, 1998, 1999 and 2000. Data were gathered by interviewing a sample of 210 tenants each year. All interviews were conducted using a standard questionnaire. The vaccination coverage for influenza in this population was found to be as low as around 30%. The main reason reported for non-vaccination was a lack of knowledge of the recommendations. The results clearly demonstrate that the single most important factor needed to attain high coverage is information, both to the people defined to be at risk and to health-care professionals.
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| 3. |
- Foberg, U, et al.
(författare)
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Viral haemorrhagic fever in Sweden : experiences from management of a case.
- 1991
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Ingår i: Scandinavian Journal of Infectious Diseases. - 0036-5548 .- 1651-1980. ; 23:2, s. 143-151
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Tidskriftsartikel (refereegranskat)abstract
- The first recognized case in Scandinavia with potential man to man transmission of viral haemorrhagic fever occurred in Linköping, Sweden, in January 1990. Following a visit to Kenya a 21-year-old male student suffered a very severe illness including extremely prolonged high grade fever, rash, disseminated intravascular coagulation with thrombocytopenia and severe bleedings. This necessitated one month of intensive care support including respirator treatment. The patient was discharged after 2 1/2 months in good condition, with a partial femoral nerve paresis. About 100 medical personnel were exposed to aerosol or blood before a strict containment regimen was established. No secondary cases occurred.
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| 4. |
- Normann, EK, et al.
(författare)
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Treatment of acute neonatal bacterial conjunctivitis: a comparison of fucidic acid to chloramphenicol eye drops
- 2002
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Ingår i: Acta Ophthalmologica Scandinavica. - : Wiley. - 1395-3907. ; 80:2, s. 183-187
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic(R): 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. Methods: A total of 456 newborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of life were included in the study. They were randomly assigned to a 7-day treatment with eye drops using either fucidic acid (1.0%) (Fucithalmic(R)) applied or chloramphenicol (0.5%) (Minims(R) Chloramphenicol) applied twice per day six times per day. The subjects were followed up with two visits (on days 1 and 8) and by telephone 2 weeks after the end of treatment. Results: Eighty-nine per cent of the neonates treated with Fucithalmic(R) were cured, compared to 87.9% of those treated with Minims(R) Chloramphenicol (n.s). The drug was used as instructed in 90.7% of patients treated with Fucithalmic(R) and in 78.0% of those treated with Minims(R) Chloramphenicol (P < 0.001). Conclusion: Treating neonatal conjunctivitis with fucidic acid is easier than with chloramphenicol and is equally effective.
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