| 1. |
- Berndt, Sonja, I, et al.
(författare)
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
- 2022
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:12, s. 2835-2844
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Tidskriftsartikel (refereegranskat)abstract
- Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
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| 2. |
- North, Eve V., et al.
(författare)
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WISDOM project – V. Resolving molecular gas in Keplerian rotation around the supermassive black hole in NGC 0383
- 2019
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 490:1, s. 319-330
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Tidskriftsartikel (refereegranskat)abstract
- As part of the mm-Wave Interferometric Survey of Dark Object Masses (WISDOM), we present a measurement of the mass of the supermassive black hole (SMBH) in the nearby early-type galaxy NGC 0383 (radio source 3C 031). This measurement is based on Atacama Large Millimeter/sub-millimeter Array (ALMA) cycle 4 and 5 observations of the 12CO(2–1) emission line with a spatial resolution of 58 × 32 pc2 (0.18 arcsec × 0.1 arcsec). This resolution, combined with a channel width of 10 km s−1, allows us to well resolve the radius of the black hole sphere of influence (measured as RSOI = 316 pc = 0.98 arcsec), where we detect a clear Keplerian increase of the rotation velocities. NGC 0383 has a kinematically relaxed, smooth nuclear molecular gas disc with weak ring/spiral features. We forward model the ALMA data cube with the KINEMATIC MOLECULAR SIMULATION (KinMS) tool and a Bayesian Markov Chain Monte Carlo method to measure an SMBH mass of (4.2 ± 0.7) × 109 M, a F160W-band stellar mass-to-light ratio that varies from 2.8 ± 0.6 M/LF160W in the centre to 2.4 ± 0.3 M/LF160W at the outer edge of the disc and a molecular gas velocity dispersion of 8.3 ± 2.1 km s−1(all 3σ uncertainties). We also detect unresolved continuum emission across the full bandwidth, consistent with synchrotron emission from an active galactic nucleus. This work demonstrates that low-J CO emission can resolve gas very close to the SMBH (≈ 140 000 Schwarzschild radii) and hence that the molecular gas method is highly complimentary to megamaser observations, as it can probe the same emitting material.
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