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- Auffray, C., et al.
(författare)
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COVID-19 and beyond : a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight
- 2020
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Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 9, s. 1130-18
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Tidskriftsartikel (refereegranskat)abstract
- Background: Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) belongs to a subgroup of coronaviruses rampant in bats for centuries. It caused the coronavirus disease 2019 (COVID-19) pandemic. Most patients recover, but a minority of severe cases experience acute respiratory distress or an inflammatory storm devastating many organs that can lead to patient death. The spread of SARS-CoV-2 was facilitated by the increasing intensity of air travel, urban congestion and human contact during the past decades. Until therapies and vaccines are available, tests for virus exposure, confinement and distancing measures have helped curb the pandemic. Vision: The COVID-19 pandemic calls for safeguards and remediation measures through a systemic response. Self-organizing initiatives by scientists and citizens are developing an advanced collective intelligence response to the coronavirus crisis. Their integration forms Olympiads of Solidarity and Health. Their ability to optimize our response to COVID-19 could serve as a model to trigger a global metamorphosis of our societies with far-reaching consequences for attacking fundamental challenges facing humanity in the 21st century. Mission: For COVID-19 and these other challenges, there is no alternative but action. Meeting in Paris in 2003, we set out to "rethink research to understand life and improve health." We have formed an international coalition of academia and industry ecosystems taking a systems medicine approach to understanding COVID-19 by thoroughly characterizing viruses, patients and populations during the pandemic, using openly shared tools. All results will be publicly available with no initial claims for intellectual property rights. This World Alliance for Health and Wellbeing will catalyze the creation of medical and health products such as diagnostic tests, drugs and vaccines that become common goods accessible to all, while seeking further alliances with civil society to bridge with socio-ecological and technological approaches that characterise urban systems, for a collective response to future health emergencies.
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- Lebzelter, T., et al.
(författare)
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Comparative modelling of the spectra of cool giants
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 547, s. A108-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Our ability to extract information from the spectra of stars depends on reliable models of stellar atmospheres and appropriate techniques for spectral synthesis. Various model codes and strategies for the analysis of stellar spectra are available today. Aims. We aim to compare the results of deriving stellar parameters using different atmosphere models and different analysis strategies. The focus is set on high-resolution spectroscopy of cool giant stars. Methods. Spectra representing four cool giant stars were made available to various groups and individuals working in the area of spectral synthesis, asking them to derive stellar parameters from the data provided. The results were discussed at a workshop in Vienna in 2010. Most of the major codes currently used in the astronomical community for analyses of stellar spectra were included in this experiment. Results. We present the results from the different groups, as well as an additional experiment comparing the synthetic spectra produced by various codes for a given set of stellar parameters. Similarities and differences of the results are discussed. Conclusions. Several valid approaches to analyze a given spectrum of a star result in quite a wide range of solutions. The main causes for the differences in parameters derived by different groups seem to lie in the physical input data and in the details of the analysis method. This clearly shows how far from a definitive abundance analysis we still are.
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- Nowotny, H, et al.
(författare)
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Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
- 2021
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Ingår i: Endocrine. - : Springer Science and Business Media LLC. - 1559-0100 .- 1355-008X. ; 71:3, s. 586-594
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Tidskriftsartikel (refereegranskat)abstract
- Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and secondary adrenal insufficiency in Europe is estimated to be 20–50/100.000. A growing number of AI cases are due to side effects of GC treatment used in different treatment strategies for cancer and to immunotherapy in cancer treatment. The benefit of hormone replacement therapy is evident but long-term adverse effects may arise due to the non-physiological GC doses and treatment regimens used. Given multiple GC replacement formulations available comprising short-acting, intermediate, long-acting and novel modified-release hydrocortisone as well as subcutaneous formulations, this review offers a concise summary on the latest therapeutic improvements for treatment of AI and prevention of adrenal crises. As availability of various glucocorticoid formulations and access to expert centers across Europe varies widely, European Reference Networks on rare endocrine conditions aim at harmonizing treatment and ensure access to specialized patient care for individual case-by-case treatment decisions. To improve the availability across Europe to cost effective oral and parenteral formulations of hydrocortisone will save lives.
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| 15. |
- Rau, G., et al.
(författare)
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The adventure of carbon stars : Observations and modeling of a set of C-rich AGB stars
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 600
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Tidskriftsartikel (refereegranskat)abstract
- Context. Modeling stellar atmospheres is a complex and intriguing task in modern astronomy. A systematic comparison of models with multi-technique observations is the only efficient way to constrain the models. Aims. We intend to perform self-consistent modeling of the atmospheres of six carbon-rich AGB stars (R Lep, R Vol, Y Pav, AQ Sgr, U Hya, and X TrA) with the aim of enlarging the knowledge of the dynamic processes occurring in their atmospheres. Methods. We used VLTI/MIDI interferometric observations, in combination with spectro-photometric data, and compared them with self-consistent, dynamic model atmospheres. Results. We found that the models can reproduce spectral energy distribution (SED) data well at wavelengths longer than 1 mu m, and the interferometric observations between 8 mu m and 10 mu m. Discrepancies observed at wavelengths shorter than 1 mu m in the SED, and longer than 10 mu m in the visibilities, could be due to a combination of data- and model-related effects. The models best fitting the Miras are significantly extended, and have a prominent shell-like structure. On the contrary, the models best fitting the non-Miras are more compact, showing lower average mass loss. The mass loss is of episodic or multi-periodic nature but causes the visual amplitudes to be notably larger than the observed ones. A number of stellar parameters were derived from the model fitting: T-Ross, L-Ross, M, C/O, and. M. Our findings agree well with literature values within the uncertainties. TRoss, and LRoss are also in good agreement with the temperature derived from the angular diameter T(theta((V-K))) and the bolometric luminosity from the SED fitting L-bol, except for AQ Sgr. The possible reasons are discussed in the text. Finally, theta(Ross) and theta((V-K)) agree with one another better for the Miras than for the non-Miras targets, which is probably connected to the episodic nature of the latter models. We also located the stars in the H-R diagram, comparing them with evolutionary tracks. We found that the main derived properties (L, T-eff, C/O ratios and stellar masses) from the model fitting are in good agreement with TP-AGB evolutionary calculations for carbon stars carried out with the COLIBRI code.
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- Wittkowski, M., et al.
(författare)
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Aperture synthesis imaging of the carbon AGB star R Sculptoris: Detection of a complex structure and a dominating spot on the stellar disk
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 601
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We present near-infrared interferometry of the carbon-rich asymptotic giant branch (AGB) star R Sculptoris (R Scl). Methods. We employ medium spectral resolution K-band interferometry obtained with the instrument AMBER at the Very Large Telescope Interferometer (VLTI) and H-band low spectral resolution interferometric imaging observations obtained with the VLTI instrument PIONIER. We compare our data to a recent grid of dynamic atmosphere and wind models. We compare derived fundamental parameters to stellar evolution models. Results. The visibility data indicate a broadly circular resolved stellar disk with a complex substructure. The observed AMBER squared visibility values show drops at the positions of CO and CN bands, indicating that these lines form in extended layers above the photosphere. The AMBER visibility values are best fit by a model without a wind. The PIONIER data are consistent with the same model. We obtain a Rosseland angular diameter of 8.9 ± 0.3 mas, corresponding to a Rosseland radius of 355 ± 55 R?, an effective temperature of 2640 ± 80 K, and a luminosity of log L/L? = 3.74 ± 0.18. These parameters match evolutionary tracks of initial mass 1.5 ± 0.5 M? and current mass 1.3 ± 0.7 M?. The reconstructed PIONIER images exhibit a complex structure within the stellar disk including a dominant bright spot located at the western part of the stellar disk. The spot has an H-band peak intensity of 40% to 60% above the average intensity of the limb-darkening-corrected stellar disk. The contrast between the minimum and maximum intensity on the stellar disk is about 1:2.5. Conclusions. Our observations are broadly consistent with predictions by dynamic atmosphere and wind models, although models with wind appear to have a circumstellar envelope that is too extended compared to our observations. The detected complex structure within the stellar disk is most likely caused by giant convection cells, resulting in large-scale shock fronts, and their effects on clumpy molecule and dust formation seen against the photosphere at distances of 2-3 stellar radii. © ESO, 2017.
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