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1.
  • Bauer, Fredric, et al. (författare)
  • Petrochemicals and climate change: Powerful fossil fuel lock-ins and interventions for transformative change
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • With the risk of climate breakdown, pressure is increasing for all sectors of the economy to break with fossil fuel dependence and reduce greenhouse gas emissions. In this context, the chemical industry requires more focused attention as it uses more fossil-fuel based energy than any other industry and the production of chemicals is associated with very large emissions. Beyond the climate crisis, the chemical industry significantly impacts several critical dimensions of sustainability, including the planetary boundaries for novel entities, biosphere integrity, and ocean acidification. In this report, we focus on the petrochemical sector, which represents the largest share of the chemicals industry and is generally understood to refer to the part of the industry that relies on fossil-fuel feedstocks from oil, gas, and coal. The petrochemicals sector produces chemicals mainly used for plastics and fertilisers, but the products also end up in paints, pharmaceuticals, pesticides, and other applications. This report provides a critical exploration of the petrochemical sector to strengthen awareness of its relevance to the climate crisis and to provide tools and recommendations for decision-makers in different domains to initiate, support, and accelerate much-needed transformation. The report highlights the rapid expansion of the petrochemical sector as well as the range and growth of economic, infrastructural, and political interlinkages with the fossil fuel extraction sector. It argues that these developments and dynamics are crucial to understanding pathways, strategies, and interventions for a low-carbon transition for petrochemicals.
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2.
  • Cedstrand, Emma, et al. (författare)
  • A Participatory Intervention to Improve the Psychosocial Work Environment and Mental Health in Human Service Organisations. A Mixed Methods Evaluation Study
  • 2021
  • Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Work-related stress is a global problem causing suffering and economic costs. In Sweden, employees in human service occupations are overrepresented among persons on sick leave due to mental health problems such as stress-related disorders. The psychosocial work environment is one contributing factor for this problem, making it urgent to identify effective methods to decrease stress at the workplace. The aim of the study is to evaluate a participatory intervention to improve the psychosocial work environment and mental health using an embedded mixed methods design. The study is a controlled trial with a parallel process evaluation exploring fidelity and participants' reactions to the intervention activities, experiences of learning and changes in behaviours and work routines. We collected data through documentation, interviews and three waves of questionnaires. Our results show small changes in behaviours and work routines and no positive effects of the intervention on the psychosocial work environment nor health outcomes. One explanation is end-users' perceived lack of involvement over the process causing the intervention to be seen as a burden. Another explanation is that the intervention activities were perceived targeting the wrong organisational level. A representative participation over both content and process can be an effective strategy to change psychosocial working conditions and mental health.
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3.
  • Cedstrand, Emma, et al. (författare)
  • Co-Creating an Occupational Health Intervention within the Construction Industry in Sweden : Stakeholder Perceptions of the Process and Output
  • 2021
  • Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:24
  • Tidskriftsartikel (refereegranskat)abstract
    • One way to prevent work-related stress, is to implement primary occupational health interventions aimed at improving the psychosocial work environment. However, such interventions have shown a limited effect, often due to implementation failure and poor contextual fit. Co-creation, where researchers, together with end-users and other relevant stakeholders, develop the intervention is increasingly encouraged. However, few studies have evaluated the effects of co-created interventions, and participants' experience of the co-creation process. This is one of the first studies evaluating stakeholder perceptions of co-creating an occupational health intervention. We applied a thematic analysis, with data from 12 semi-structured interviews with stakeholders involved in the co-creation. Our results show that the respondents, in general, were satisfied with engaging in the co-creation, and they reported an increased awareness regarding risk factors of stress and how these should be handled. Additionally, the respondents described trust in the intervention activities and a good fit into the context. The study indicates that co-creating occupational health interventions can enhance the implementation and the contextual fit.
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4.
  • Cedstrand, Emma, et al. (författare)
  • Effects of a co-created occupational health intervention on stress and psychosocial working conditions within the construction industry : a controlled trial
  • 2022
  • Ingår i: Frontiers In Public Health. - : Frontiers Media S.A.. - 2296-2565. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Work-related stress problems, i.e., burnout, depression, and anxiety, is a rising global health challenge. Poor mental health also appears to be a challenge for the construction industry, even though the occupational health focus has traditionally been on the physical work environment and musculoskeletal disorders. Yet, studies targeting the organisational level (i.e., work environment, policy) to enhance mental health within the construction industry are scant. Therefore, our first objective was to evaluate the effectiveness of a co-created occupational health intervention on stress and psychosocial working conditions within the construction industry in Sweden. The second objective was to evaluate whether the intervention was implemented as intended, i.e., implementation fidelity. The trial is registered in the ISRCTN clinical trial registry (ISRCTN16548039, ). Methods This is a controlled trial with one intervention and one matched control group. We co-created the program logic with stakeholders from the intervention group. The essence of the chosen intervention components, duties clarification, and structured roundmaking was enhanced planning and role clarification. We assessed adherence to the intervention and dose delivered (i.e., fidelity). We collected data on the outcomes (role clarity, team effectiveness, planning, staffing, quantitative demands, and the psychosocial safety climate) with online questionnaires at baseline, 12, and 24 months. Marginal means models adjusting for missing data patterns were applied to estimate potential differences in outcomes between groups over time. Results Fidelity was considered reasonably high. Yet, we found no intervention effects on the primary outcome stress. All outcomes, except role clarity deteriorated during the trial in the intervention and control group. However, the results indicate a positive effect of the intervention components on professionals' role clarity. The pandemic appears to have negatively affected stress and psychosocial working conditions. Conclusion The study's results suggest that co-creating occupational health interventions could be one solution for improved implementation fidelity. More studies are needed to evaluate these intervention components. Also, we recommend researchers of future intervention studies consider using missing not at random, sensitivity analysis.
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5.
  • Cedstrand, Emma, et al. (författare)
  • Study protocol of a co-created primary organizational-level intervention with the aim to improve organizational and social working conditions and decrease stress within the construction industry : a controlled trial
  • 2020
  • Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 20:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Within construction industry, physical work exposures have long been recognized as possible determinants for musculoskeletal disorders, but less attention has been given the increasing organizational and social work hazards and stress within this industry. There is to date a lack of knowledge about how to improve organizational and social working conditions and decrease stress within the construction industry.Methods: This paper outlines the design of a controlled trial to evaluate the effectiveness of a co-created organizational-level intervention with the aim to improve role clarity, quantitative demands, staffing, planning, team effectiveness, psychosocial safety climate and stress. Two regions (> 700 employees) within one large construction company in Sweden will participate as intervention and control group. Further we present the design of the process evaluation assessing fidelity, support from managers, readiness for change and contextual factors. We will utilize questionnaires, semi-structured interviews, observations and documentation as means for data collection, hence a mixed methods approach is applied.Discussion: The study is expected to contribute to the understanding of how adverse organizational and social working conditions and stress can be improved within the construction industry. By applying co-creation we wish to develop an intervention and implementation strategies that fit to the context, are in line with the needs of end-users and are supported by all management levels - all of which are highlighted features in successful workplace interventions.
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6.
  • Dima, Danai, et al. (författare)
  • Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
  • 2022
  • Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
  • Tidskriftsartikel (refereegranskat)abstract
    • Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
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7.
  • Ekström, Peter, et al. (författare)
  • Ontogenetic development of serotoninergic neurons in the brain of a teleost, the three-spined stickleback. An immunohistochemical analysis
  • 1985
  • Ingår i: Developmental Brain Research. - : Elsevier BV. - 0165-3806. ; 17:1-2, s. 209-224
  • Tidskriftsartikel (refereegranskat)abstract
    • The ontogenetic development of serotoninergic neurons in the brain of the stickleback was investigated with the indirect immunocytochemical peroxidase-antiperoxidase technique, using a specific antibody to serotonin (5-hydroxytryptamine, 5-HT). Formation of neuronal populations takes place during embryonic development. By 80 h after fertilization, the first 5-HT perikarya have appeared in the ventricular zone of the hypothalamus (nucleus recessus lateralis) and the raphe region. At 108 h the first 5-HT perikarya can be observed in area praetectalis. At 118 h a transient group of 5-HT neurons appears rostral to the nucleus recessus lateralis, and at this same age the first 5-HT perikarya may be visualized in nucleus recessus posterioris. A group of 5-HT neurons appears in the dorsolateral tegmentum at 166 h (one day after hatching, which occurs at 120-144 h after fertilization). Differentiation of the neuronal populations, in terms of migration and formation of subdivisions, starts between 80 h and 94 h, and seems to be completed between 1 and 5 days after hatching. Raphe nuclei form an anterior group comprising nuclei raphe dorsalis, raphe medialis and a ventrolateral group, and a posterior group comprising a nucleus raphe pallidus/obscurus complex, a lateral nucleus reticularis paragigantocellularis and a ventromedial nucleus raphe magnus. The posterior and ventral raphe nuclei, which are well developed at the time of hatching, have not been visualized in the adult stickleback. While formation of 5-HT neuronal systems, as well as their primary efferent pathways, takes place during early ontogenetic development, the establishment of terminal areas and their subsequent differentiation apparently takes place during later ontogenetic stages. Most presumptive target areas are penetrated by 5-HT axons at hatching, although terminal formation does not seem to start until later. A considerable number of 5-HT neuronal groups present in the embryonic and newly hatched stickleback have not been visualized in the adult stickleback. This may be due to selective cell death, changes in transmitter phenotype or maturation of axonal transport processes during development.
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8.
  • Fagerström, Anton, et al. (författare)
  • BeKind - Circularity and climate benefit of a bio- and electro-based chemical industry - effects of transitions in petrochemical value chains
  • 2022
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • This document reports the finding from the project BeKind: Circularity and climate benefit of a Bio- and Electro-based Chemical Industry - effects of transitions in petrochemical value chains. The aim of the BeKind-project has been to identify challenges for transition to a circular and climate-neutral petrochemical industry, to develop proposals for remedial activities for these obstacles and challenges, and to quantify the benefits such a transition can have for circularity, climate and social sustainability. The focus of the project has been on industrial production of liquid fuels and plastics. 
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9.
  • Frangou, Sophia, et al. (författare)
  • Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
  • 2022
  • Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
  • Tidskriftsartikel (refereegranskat)abstract
    • Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
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10.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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11.
  • Lygnerud, Kristina, et al. (författare)
  • A study on how efficient measures for secondary district heating system performance can be encouraged by motivational tariffs
  • 2023
  • Ingår i: Energy, Sustainability and Society. - 2192-0567. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: District Heating (DH) is a technology that provides heating and domestic hot water to buildings and is an important technology for supporting the European energy transition. As such the heating systems increasingly resort to renewable heat sources and waste heat, it is even more important that they operate in the most efficient way possible. DH companies have access to the primary network of which they can impact system performance. To maximize the efficiency of the system, however, it is important that the system at the building level, known as the secondary system, is also efficient; otherwise, overall system efficiency is reduced. To increase system efficiency, return temperatures from the secondary system into the primary system have been targeted through motivational tariffs. There is limited information on how to establish a motivational tariff that motivates the customer to improve both the primary and secondary systems, which is a gap that this paper aims to fill. Results: In this paper, the impacts of retrofit actions in secondary systems are assessed through simulations. The identified relevant refurbishment measures to lower the return temperature to the primary system are variable flow pumps, low-temperature radiators, parallel heat exchangers, and a pass-through DHW system. Apart from simulated refurbishments, we also identify that the secondary system sometimes generates excess heat, which is valuable to recover, especially during peak load periods for the primary system. Hence, motivational tariffs targeting secondary system efficiency should also encompass an incentive for the customer to make use of waste heat in the secondary circuit to lower peak demand for the DH system. Conclusions: To date, the most commonly used parameters introduced to customers are linked to the flow of water through the customer’s asset and the bonus malus principle. The results from simulations show that DH companies can introduce additional parameters to support customers in guiding their secondary system to perform more efficiently. Increased overall system efficiency has a positive impact on both costs and emissions.
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12.
  • Nyberg, Theo, et al. (författare)
  • Bioenergianläggning Otterbäcken
  • 2022
  • Rapport (refereegranskat)abstract
    • Transportsektorns efterfrågan på biodrivmedel ökar när klimatomställningen ska omsättas i praktik. Sverige har goda förutsättningar att producera dessa drivmedel och det finns flertalet orter runt om i landet där förutsättningarna för biodrivmedelsproduktion är goda. Gullspångs kommun har under de senaste tio åren fört en dialog med Västra Götalandsregionen om möjligheten att etablera en bioenergikombinatanläggning i Otterbäcken för att nyttja de goda förutsättningar som finns med tillgång på råvara samt goda logistiska förutsättningar med bland annat djuphamnen. I detta projekt har en utredning gjorts för att ta fram kommersiellt relevanta investeringskoncept för en bioenergikombinatanläggning i Otterbäcken, och resultaten pekar på intressanta förutsättningar för en anläggning för produktion av flytande biometan (Liquified biogas, LBG).Projektet har utgått från en äldre förstudie där förutsättningarna för en bioenergikombinat-anläggning som producerar torrefierad biomassa undersöktes. Kunskaperna från denna tidigare studie har kompletterats med nya kartläggningar av relevanta tekniker och lokala råvaror som kan ingå i ett investeringskoncept för en anläggning som producerar biodrivmedel som kan användas i befintliga tunga lastbilar. Kartläggningen omfattade sju olika tekniker som utifrån de uppdaterade kartläggningarna kondenserades ned till två investeringskoncept för djupare undersökning av investeringskoncept. Det ena konceptet var en anläggning för produktion av pyrolysolja från skogsrester och det andra konceptet var en anläggning för produktion av LBG, men på grund av en högre teknologisk mognadsgrad samt större intresse från referensgruppen för det senare konceptet (LBG) så fick detta ett större fokus i projektet.De två fördjupade investeringskoncepten inkluderade teknikbeskrivning, skiss på affärsmodell med hjälp av referensgruppen, ekonomisk bedömning av lönsamheten i investeringen samt en beräkning av klimatpåverkan för drivmedlet (endast för LBG-konceptet).Resultaten visar att det ser ut att finnas både råvaror för, teknik till och förutsättningar för en god ekonomi i en anläggning för produktion av LBG. Råvarusituationen behöver bekräftas genom kontakter med råvaruleverantörer, tekniken kan behöva viss utvärdering för att hitta etablerade teknikleverantörer med pålitlig teknik och de ekonomiska förutsättningarna är beroende av investerings- och produktionsstöd för att kunna vara kommersiellt intressanta. Trots dessa osäkerheter är den samlade bedömningen att det kan vara aktuellt för en aktör eller grupp av aktörer med intresse av att äga och driva en biogasanläggning att ta vid där projektet slutar för att på sikt gå vidare med en investering i en anläggning.
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13.
  • Rootzén, Johan, et al. (författare)
  • Holistic, actionable, transparent – How could sustainability of energy systems scenarios be assessed? - Findings from the project “100 percent renewable – how  many percent sustainable?”
  • 2023
  • Rapport (populärvet., debatt m.m.)abstract
    • In the context of achieving a climate-neutral and sustainable electricity system, energy systems modelling is often used as a tool to assist decision making. However, a challenge posed within the field is how to represent sustainability in a way that presents actionable, clear and holistic results. There is thus a need to give a more comprehensive and nuanced view of sustainability aspects of energy system modelling.To provide a basis of understanding of how sustainability could be conceptualized and assessed in energy systems modelling, six well known (from a Swedish point-of-view) sustainability frameworks were analyzed and presented in this report: the concept of Environmental Carrying Capacity, the Planetary Boundaries, the Doughnut Economics framework, the Sustainable Development Goals, the Swedish Environmental Quality Objectives and the Framework for Strategic Sustainable Development. The frameworks were structured according to their sustainability concept and according to what decision-making they would be able to provide input to. The results of the report serve as input to the discourse concerning how the energy system could be transformed to 100 % renewable electricity production along a truly sustainable way.
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14.
  • Rootzén, Johan, et al. (författare)
  • Turning the tanker? Exploring the preconditions for change in the global petrochemical industry
  • 2023
  • Ingår i: Energy Research & Social Science. - 2214-6326 .- 2214-6296. ; 104:103256
  • Tidskriftsartikel (refereegranskat)abstract
    • Meeting the goals set out in the Paris Agreement will require rapid and deep reductions of greenhouse gas emissions (GHG) across all sectors of the global economy. Like all major societal transformations, this climate transition will impact both social and technical aspects of society and, depending on how it evolves, will reallocate social and economic benefits and costs differently. Recognising the importance of decarbonising key industry sectors with large GHG emissions and an significant impact on society, this study explores the opportunities and tensions involved in a transition of the petrochemical industry. We do so by analysing how access to natural resources, the petrochemical industry's role in the economy and the socio-political landscape in key petrochemical producing countries impacts prerequisites for change. The assessment shows that devising adequate policy responses, building legitimacy for change and potentially building bottom-up pressure for a timely climate transition are likely to look very different in the 10 countries with the greatest active petrochemical capacity in the world: China, the United States, India, South Korea, Saudi Arabia, Japan, Russia, Iran, Germany and Taiwan. The indicators used to explore the prerequisites for change all point to areas where actions and policies must advance for a transition to be realised. This includes efforts to cap fossil feedstock supply and production capacity, efforts to limit and ultimately reduce demand for plastics and fertilisers, and measures to formulate transition strategies and policies that capture and provide agency for communities and groups that are currently on the receiving end of negative health and environmental impacts from the petrochemical industry and that will also, in many cases, be most closely affected by a transition.
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15.
  • Satizabal, Claudia L., et al. (författare)
  • Genetic architecture of subcortical brain structures in 38,851 individuals
  • 2019
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
  • Tidskriftsartikel (refereegranskat)abstract
    • Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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16.
  • Thompson, Paul M., et al. (författare)
  • The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
  • 2014
  • Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
  • Tidskriftsartikel (refereegranskat)abstract
    • The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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17.
  • van Veen, Theo, et al. (författare)
  • Serotonin and opsin immunoreactivities in the developing pineal organ of the three-spined stickleback, Gasterosteus aculeatus L.
  • 1984
  • Ingår i: Cell and Tissue Research. - 0302-766X. ; 237:3, s. 559-564
  • Tidskriftsartikel (refereegranskat)abstract
    • 5-hydroxytryptamine (5-HT, serotonin)- and opsin-immunoreactive sites were studied in the developing pineal complex of the stickleback, Gasterosteus aculeatus L., by use of light-microscopic indirect immunoperoxidase techniques. 5-HT immunoreactivity first occurs in the pineal organ at the age of 80 h after fertilization and appears to be localized in cells of the photoreceptor type. The outer segments of a few pineal photosensory cells exhibit opsin immunoreactivity at the age of 84 h after fertilization. The number of cells seems to increase until the pineal organ is completely developed. The increase in the number of 5-HT immunoreactive perikarya runs parallel in time to that of the opsinimmunoreactive outer segments. The cells of the parapineal organ show neither opsin nor 5-HT immunoreactivity. The retina of the embryonic stickleback does not display opsin immunoreactivity until after hatching, which takes place about 144 h after fertilization. These results suggest, in the three-spined stickleback, an earlier light-perception capacity for the developing pineal organ than for the retina.
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Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
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