SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Nylander Maria) "

Sökning: WFRF:(Nylander Maria)

  • Resultat 1-50 av 81
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  • Alsterholm, Mikael, 1977, et al. (författare)
  • Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
  • 2023
  • Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
  • Tidskriftsartikel (refereegranskat)abstract
    • SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
  •  
4.
  • Arvidsson, Susann, 1965-, et al. (författare)
  • People's perceptions of their phone call with rheuma directly, a rheumatic diseases helpline
  • 2017
  • Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 76:Suppl. 2, s. 1544-1545
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Information on rheumatic diseases is often complex to understand or scary, and additional support is often necessary. Rheuma Directly (RD) is a helpline with specially trained nurses on rheumatic diseases, funded by the Swedish Rheumatism Association and Spenshult Research and Development Centre. Little is known of how people calling a helpline perceive the contact.Objectives To describe the variation in how people perceive the contact with the helpline RD.Methods The study had a descriptive, qualitative design with a phenomenographic approach and was carried out by means of 27 semi-structured telephone interviews. The informants were 22 female and 5 men, and their ages ranged from 22 to 89 years (mean 54 years).Results The informants called RD when they had problems getting answers to their questions through the Internet or from healthcare professionals. Three different description categories emerged: Specific competence, Constructive dialogue, and Applicability. The informants' perceived Specific competence when the nurses were knowledgeable, the call was complementary to previously received information and when the informants had greater knowledge after the contact with RD. They perceived that it was a Constructive dialogue when they got someone to discuss with, a “sounding board”, and perceived emotional support, felt reassured and were satisfied with the answer. The informants perceived Applicability because RD was available and they could make different choices according to their own desire; before (how and when they would contact RD), during (what to tell and what question they would ask) and after (how and what they would do after the contact with RD).Conclusions People calling RD perceived that the telephone call with the nurses meant meeting specific competence, gaining constructive dialogue and that the helpline was applicable. This knowledge ad to a fuller understanding of factors that from a caller's perspective, are important when calling a helpline with specially trained nurses on rheumatic diseases. © 2017, Published by the BMJ Publishing Group Limited.
  •  
5.
  • Backman, Ellen, 1981-, et al. (författare)
  • Metoder för att stimulera språk och kommunikation hos barn, ungdomar och vuxna inom habiliteringen
  • 2015
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Språkliga och kommunikativa begränsningar är vanligt förekommande vid ett flertal av de diagnoser och tillstånd som återfinns hos personer inom habiliteringsverksamheter i Sverige och förutsätter en tvärprofessionell och långvarig insats. Syftet med föreliggande arbete är att systematiskt beskriva bästa tillgängliga evidens avseende interventioner fokuserade på språklig och kommunikativ förmåga för personer med medfödda funktionsnedsättningar från sex års ålder och uppåt inom habiliteringsverksamhet. Arbetet kan ses som en fortsättning på EBH-rapporten ”Tidiga kommunikations- och språkinsatser till förskolebarn”.Internationellt publicerade interventionsstudier från de senaste 15 åren med fokus på språkliga och kommunikativa förmågor vid typiskt förekommande diagnoser inom habiliteringsverksamhet granskades och sammanfattades. Initialt inkluderades endast översiktsartiklar och metaanalyser, men då dessa till största delen hade fokus på autism och/eller Alternativ och Kompletterande Kommunikation (AKK) utökades sökningen till att även inkludera ett antal primärstudier med annat fokus. Rapporten omfattar 67 studier.Resultatet visar att ”stark rekommendation att använda” (enligt GRADE) endast förekommer i begränsad utsträckning, och när det förekommer är det vid insatser relaterade till autism och/eller AKK. ”Stark rekommendation att inte använda” finns vid insatser relaterade till akupunktur/akupressur och faciliterad kommunikation. Det kan konstateras att det finns en stor brist på studier avseende vuxna personer respektive intellektuell funktionsnedsättning.Detta arbete tillför ytterligare kunskap till området för evidensbaserade insatser vid svårigheter när det gäller kommunikation och språk, och visar att evidens i strikt bemärkelse är svår att erhålla bland annat beroende på de små och heterogena patientgrupperna och, som en konsekvens av detta, en brist på stora randomiserade studier.
  •  
6.
  • Badell, Maria Valldeperas, et al. (författare)
  • Lipid Sponge-Phase Nanoparticles as Carriers for Enzymes
  • 2018
  • Ingår i: Biophysical Journal. - : Cell Press. - 0006-3495 .- 1542-0086. ; 114:3, suppl 1, s. 15A-15A
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Immobilization of enzymes into different support materials has been widely studied as means to control their activity and stability. Here we will consider lipid liquid crystalline phases as enzyme carriers, as they have been demonstrated to have a high potential in a range of applications such as drug delivery, protein encapsulation or crystallization thanks to the wide range of self-assembly structures they can form, which have cavities of nano-scale dimensions. Furthermore, such structures have also been observed in a range of living organisms. Although, reverse cubic or hexagonal lipid aqueous phase can be used to entrap smaller biomolecules, it is still challenging to encapsulate bioactive macromolecules, such as proteins. Here, we will present a novel lipid system able to form highly swollen sponge phases (L3), with aqueous pores up to 13 nm of diameter. We will show that this structure is preserved even in excess aqueous solution, where they form sponge-like nanoparticles (L3 NPs) in which two enzymes of different sizes, Aspartic protease and beta-galactosidase (34 KDa and 460 KDa, respectively), could be included. To reveal the nature of the interaction between the enzymes and the lipid matrix, we studied the adsorption of both proteins on the lipid layers formed by the L3 NPs. The results will be discussed in terms of the ability of these nanoparticles to encapsulate and release of the proteins in the lipid matrix.
  •  
7.
  •  
8.
  •  
9.
  • Chang, Debby, et al. (författare)
  • Non-lamellar lipid liquid crystalline structures at interfaces
  • 2015
  • Ingår i: Advances in Colloid and Interface Science. - : Elsevier. - 0001-8686 .- 1873-3727. ; 222, s. 135-147
  • Forskningsöversikt (refereegranskat)abstract
    • The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in biomedical devices for analyses and drug delivery, it is crucial to understand how they interact with and respond to different types of interfaces. Such non-lamellar interfacial layers can be used to entrap functional biomolecules that respond to lipid curvature as well as the confinement. It is also important to understand the structural changes of deposited lipid in relation to the corresponding bulk dispersions. They can be controlled by changing the lipid composition or by introducing components that can alter the curvature or by deposition on nano-structured surface, e.g. vertical nano-wire arrays. Progress in the area of liquid crystalline lipid based nanoparticles opens up new possibilities for the preparation of well-defined surface films with well-defined nano-structures. This review will focus on recent progress in the formation of non-lamellar dispersions and their interfacial properties at the solid/liquid and biologically relevant interfaces.
  •  
10.
  • Chang, Debby P., et al. (författare)
  • Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces
  • 2016
  • Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084. ; 18:38, s. 26630-26642
  • Tidskriftsartikel (refereegranskat)abstract
    • Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I-2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules. Their interactions with various interfaces, and the consequences for the particle structure and integrity, are essential considerations in their effectiveness as drug delivery vehicles. Here, we have studied LCNPs formed of equal fractions of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and glycerol dioleate in the presence of different fractions of the stabilizer Polysorbate 80. We have used a combination of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectometry to reveal the structure and composition of the adsorbed layer on both anionic silica and cationic (aminopropyltriethoxysilane) silanized surfaces. For both types of surfaces, there is a spread near-surface layer comprising lipid and polymer as well as a sparse coverage of intact particles. The composition of the near-surface layer is very close to that of the particles, in contrast to the lipid bilayer observed with related systems. The interaction is stronger for cationic than anionic surfaces, which is rationalized in terms of the negative zeta potential of the LCNPs. The work shows that the attachment of and spreading from LCNPs is influenced by the properties of the surface, the internal structure, composition and stability of the particles as well as the nature of the stabilizer.
  •  
11.
  • Comasco, Erika, 1982-, et al. (författare)
  • Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression
  • 2019
  • Ingår i: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 10:7, s. 3132-3142
  • Tidskriftsartikel (refereegranskat)abstract
    • Interactive effects between allelic variants of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) and stressors on depression symptoms have been documented, as well as questioned, by meta-analyses. Translational models of constitutive 5-htt reduction and experimentally controlled stressors often led to inconsistent behavioral and molecular findings and often did not include females. The present study sought to investigate the effect of 5-htt genotype, maternal separation, and sex on the expression of stress-related candidate genes in the rat hippocampus and frontal cortex. The mRNA expression levels of Avp, Pomc, Crh, Crhbp, Crhr1, Bdnf, Ntrk2, Maoa, Maob, and Comt were assessed in the hippocampus and frontal cortex of 5-htt± and 5-htt+/+ male and female adult rats exposed, or not, to daily maternal separation for 180 min during the first 2 postnatal weeks. Gene- and brain region-dependent, but sex-independent, interactions between 5-htt genotype and maternal separation were found. Gene expression levels were higher in 5-htt+/+ rats not exposed to maternal separation compared with the other experimental groups. Maternal separation and 5-htt+/− genotype did not yield additive effects on gene expression. Correlative relationships, mainly positive, were observed within, but not across, brain regions in all groups except in non-maternally separated 5-htt+/+ rats. Gene expression patterns in the hippocampus and frontal cortex of rats exposed to maternal separation resembled the ones observed in rats with reduced 5-htt expression regardless of sex. These results suggest that floor effects of 5-htt reduction and maternal separation might explain inconsistent findings in humans and rodents.
  •  
12.
  • Dabkowska, Aleksandra P., et al. (författare)
  • Non-lamellar lipid assembly at interfaces : controlling layer structure by responsive nanogel particles
  • 2017
  • Ingår i: Interface Focus. - : ROYAL SOC. - 2042-8898 .- 2042-8901. ; 7:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing three-dimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid non-lamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.
  •  
13.
  • Dabkowska, A. P., et al. (författare)
  • Temperature responsive lipid liquid crystal layers with embedded nanogels
  • 2017
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 53:8, s. 1417-1420
  • Tidskriftsartikel (refereegranskat)abstract
    • Polymer nanogels are embedded within layers consisting of a nonlamellar liquid crystalline lipid phase to act as thermoresponsive controllers of layer compactness and hydration. As the nanogels change from the swollen to the collapsed state via a temperature trigger, they enable on-demand release of water from the mixed polymer-lipid layer while the lipid matrix remains intact. Combining stimuli-responsive polymers with responsive lipid-based mesophase systems opens up new routes in biomedical applications such as functional biomaterials, bioanalysis and drug delivery.
  •  
14.
  • Emanuelsson, Ida, et al. (författare)
  • Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system : potential effects of vitamin D on brain steroidogenesis
  • 2018
  • Ingår i: Neurochemistry International. - : Elsevier BV. - 0197-0186 .- 1872-9754. ; 113, s. 46-55
  • Tidskriftsartikel (refereegranskat)abstract
    • Steroids are reported to have diverse functions in the nervous system. Enzymatic production of steroid hormones has been reported in different cell types, including astrocytes and neurons. However, the information on some of the steroidogenic enzymes involved is insufficient in many respects. Contradictory results have been reported concerning the relative importance of different cell types in the nervous system for expression of CYP17A1 and 3b-hydroxysteroid dehydrogenase (3b-HSD). 3b-HSD is important in all basic steroidogenic pathways and CYP17A1 is required to form sex hormones. In the current investigation we studied the expression of these enzymes in cultured primary rat astrocytes, in neuron-enriched cells from rat cerebral cortex and in human neuroblastoma SH-SY5Y cells, a cell line often used as an in vitro model of neuronal function and differentiation. As part of this study we also examined potential effects on CYP17A1 and 3b-HSD by vitamin D, a compound previously shown to have regulatory effects in steroid hormone-producing cells outside the brain. The results of our study indicate that astrocytes are a major site for expression of 3b-HSD whereas expression of CYP17A1 is found in both astrocytes and neurons. The current data suggest that neurons, contrary to some previous reports, are not involved in 3b-HSD reactions. Previous studies have shown that vitamin D can influence gene expression and hormone production by steroidogenic enzymes in some cells. We found that vitamin D suppressed CYP17A1-mediated activity by 20% in SH-SY5Ycells and astrocytes. Suppression of CYP17A1 mRNA levels was considerably stronger, about 50% in SH-SY5Y cells and 75% in astrocytes. In astrocytes 3b-HSD was also suppressed by vitamin D, about 20% at the enzyme activity level and 60% at the mRNA level. These data suggest that vitamin D-mediated regulation of CYP17A1 and 3b-HSD, particularly on the transcriptional level, may play a role in the nervous system.
  •  
15.
  • Exhibition: Space Waves and a Tale : Hannes Alfvén (1908–1995). Nobel Prize laureate in physics 1970.
  • 2022
  • Konstnärligt arbeteabstract
    • The exhibition Space Waves and a Tale presented parts of Alfvén's extensive research, his community engagement and last but not least, his fictional story The tale of the great computing machine from 1966.  In 1970 KTH professor Hannes Alfvén (1908 – 1995) was awarded the Nobel Prize in physics for his discoveries and applications in plasma physics. The exhibition Space Waves and a Tale presented parts of Alfvén's extensive research, his community engagement and his fictional story The tale of the great computing machine from 1966.Alfvén's research allow us to explore all corners of the universe – from the auroras on earth to the auroras on other planets, from solar wind to stellar wind, from plasma phenomena in the laboratory to astrophysical plasma phenomena in ours and other galaxies.The tale of the great computing machine is a satirical tale that tells the story of a future society controlled by computers and is also the source of inspiration for an opera with the same name.As part of the exhibition Space Waves and a Tale visitors were invited to share their visions of how future technology will shape our lives and societies. Two students from the KTH School of Architecture have contributed to the exhibition by designing and building a flexible and sustainable exhibition module. Students from BOOMERANG REXUS participated with objects related to aerospace research.Space Waves and a Tale was produced by the project group for KTH 200 years anniversary celebration together with KTH Library, The Opera: The Tale of the Great Computing Machine, the Division of Space and Plasma Physics and the KTH School of Architecture.In connection with the exhibithion there was a book discussion, popular science lecture and a class visit.
  •  
16.
  • Fusar-Poli, Laura, et al. (författare)
  • Psychometric properties of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ) in a sample of Italian psychiatric outpatients
  • 2020
  • Ingår i: Research in Autism Spectrum Disorders. - : Elsevier BV. - 1750-9467. ; 78
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The present study aimed to examine the reliability and validity of the Italian version of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ), a screening tool for autism spectrum disorder (ASD) among psychiatric outpatients. Methods: We recruited 340 subjects via an outpatient psychiatric service in Italy. Forty-eight had a diagnosis of ASD, confirmed after a comprehensive clinical assessment and the administration of the Autism Diagnostic Observation Schedule-2 (ADOS-2). The remaining 292 participants had other diagnoses, confirmed after a careful psychiatric evaluation and the administration of the Structured Clinical Interview for DSM-5 (SCID-5). The ASDASQ was administered to contact clinicians of each subject. Results: The ASDASQ showed outstanding accuracy (AUC = 0.96) in discriminating between ASD and non-ASD patients, with good sensitivity (0.85) and specificity (0.92). Agreement with clinical diagnosis was substantial (k = 0.68). Internal consistency of the tool was good (Cronbach's alpha = 0.82), while intra- (ICC = 0.97) and inter-rater reliability (ICC = 0.92) were excellent. We found also a moderate correlation between ASDASQ and ADOS-2 scores in the ASD sample (r = 0.56). Conclusion: Our findings suggest that the ASDASQ, in the Italian adaptation, may be considered a quick, simple, and effective tool to screen for ASD among psychiatric outpatients. Further studies are needed to evaluate its utility in other clinical settings.
  •  
17.
  • Gharehbaghi, Arash, et al. (författare)
  • A hybrid model for diagnosing sever aortic stenosis in asymptomatic patients using phonocardiogram
  • 2015
  • Ingår i: IFMBE Proceedings. - Cham : Springer. - 9783319193878 - 9783319193861 ; , s. 1006-1009
  • Konferensbidrag (refereegranskat)abstract
    • This study presents a screening algorithm for severe aortic stenosis (AS), based on a processing method for phonocardiographic (PCG) signal. The processing method employs a hybrid model, constituted of a hidden Markov model and support vector machine. The method benefits from a preprocessing phase for an enhanced learning. The performance of the method is statistically evaluated using PCG signals recorded from 50 individuals who were referred to the echocardiography lab at Linköping University hospital. All the individuals were diagnosed as having a degree of AS, from mild to severe, according to the echocardiographic measurements. The patient group consists of 26 individuals with severe AS, and the rest of the 24 patients comprise the control group. Performance of the method is statistically evaluated using repeated random sub sampling. Results showed a 95% confidence interval of (80.5%-82.8%) /(77.8%- 80.8%) for the accuracy/sensitivity, exhibiting an acceptable performance to be used as decision support system in the primary healthcare center.
  •  
18.
  • Gilbert, Jennifer, et al. (författare)
  • Immobilisation of β-galactosidase within a lipid sponge phase: structure, stability and kinetics characterisation
  • 2019
  • Ingår i: Nanoscale. - 2040-3372. ; 11:44, s. 21291-21301
  • Tidskriftsartikel (refereegranskat)abstract
    • In the formulation of an active enzyme enclosed in a matrix for controlled delivery, it is a challenge to achieve a high protein load and to ensure high activity of the protein. For the first time to our knowledge, we report the use of a highly swollen lipid sponge (L3) phase for encapsulation of the large active enzyme, β-galactosidase (β-gal, 238 kDa). This enzyme has large relevance for applications in, e.g. the production of lactose free milk products. The formulation consisted of diglycerol monooleate (DGMO), and a mixture of mono-, di- and triglycerides (Capmul GMO-50) stabilised by polysorbate 80 (P80). The advantage of this type of matrix is that it can be produced on a large scale with a fairly simple and mild process as the system is in practice self-dispersing, yet it has a well-defined internal nano-structure. Minor effects on the sponge phase structure due to the inclusion of the enzyme were observed using small angle X-ray scattering (SAXS). The effect of encapsulation on the enzymatic activity and kinetic characteristics of β-galactosidase activity was also investigated and can be related to the enzyme stability and confinement within the lipid matrix. The encapsulated β-galactosidase maintained its activity for a significantly longer time when compared to the free solution at the same temperature. Differences in the particle size and charge of sponge-like nanoparticles (L3-NPs) with and without the enzyme were analysed by dynamic light scattering (DLS) and zeta-potential measurements. Moreover, all the initial β-galactosidase was encapsulated within L3-NPs as revealed by size exclusion chromatography.
  •  
19.
  •  
20.
  • Gonçalves, Rui A., et al. (författare)
  • Facile control of surfactant lamellar phase transition and adsorption behavior
  • 2020
  • Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 10:31, s. 18025-18034
  • Tidskriftsartikel (refereegranskat)abstract
    • This study sets out to investigate the effect of the presence of small water-soluble additives on the tunability of the surfactant gel-to-liquid crystalline (Lß-La) phase transition temperature (Tm) for a bilayer-forming cationic surfactant and the phase behavior of such surfactant systems on dilution. This is strongly driven by the fact that this type of cationic surfactant has many interesting unanswered scientific questions and has found applications in various areas such as consumer care, the petrochemical industry, food science,etc.The underlying surfactant/additive interactions and the interfacial behavior of lamellar surfactant systems including the surfactant deposition on surfaces can provide new avenues to develop novel product formulations. We have examined dioctadecyldimethyl ammonium chloride (DODAC) in the presence of small polar additives, with respect to the phase behavior upon dilution and the deposition on silica. Differential scanning calorimetry (DSC) is used to track the transition temperature,Tm, and synchrotron and laboratory-based small and wide-angle X-ray scattering (SAXS and WAXS) were used to determine the self-assembled surfactant structure below and above theTm. DSC scans showed that upon dilution the additives could be removed from the surfactant bilayer which in turn tuned theTm. A spontaneous transition from a liquid crystalline (La) phase to a gel (Lß) phase on dilution was demonstrated, which indicated that additives could be taken out from the Laphase. By means ofin situnull ellipsometry, the deposition of a diluted surfactant Lßphase upon replacement of bulk solution by deionized water was followed. This technique enables time-resolved monitoring of the deposited surfactant layer thickness and adsorbed amount, which allows us to understand the deposition on surfaces. Robust layers at least one bilayer-thick were deposited onto the surface and shown to be irreversibly adsorbed due to poor surfactant solvency in water. The thickest layer of surfactant deposited after dilution was found for mixtures with small amounts of additive since high amounts might lead to a phase-separated system.
  •  
21.
  • Granholm, Linnea (författare)
  • Neurobiological Consequences of Social Conditions and Alcohol Exposure in Adolescent rats
  • 2015
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Adolescence represents a time of extensive reorganisation and maturation of brain circuits involved in emotions, motivation and cognition and it is a period particular sensitive for external stimuli. External stimuli can be both socio-environmental factors and exposure to exogenous compounds such as drugs of abuse (e.g. alcohol). If these stimuli are of an adverse nature the probability of develop neuropsychiatric diseases or addiction is increased. To study the neurobiological consequences of adverse events during adolescence animal models are crucial since they give the opportunity of providing an environment where the exposure of the stimuli is controlled and also enable a detailed analysis of the effects in the brain. The overall aim of in this thesis was to investigate how environmental factors, social conditions or alcohol exposure, during adolescence affect the brain and/or drug-taking in rats. Rats are very sensitive for dis- turbances in their social conditions and to induce an adverse social environment, early adolescent rats where single-housed for either a short or prolonged time. A short period of single housing induced an acute stress response and increased levels of nociceptin/orphanin FQ in brain areas associated with stress. Prolonged single housing reduced the levels of Met-enkephalin-Arg6Phe7 in several brain areas. Rats exposed to alcohol during adolescence had an altered dopamine response in dorsal striatum after an am- phetamine challenge but displayed similar amphetamine intake-behaviour as water controls. However, animals exposed to a combination of adolescent alcohol exposure and subsequent amphetamine intake had a more efficient removal of dopamine in dorsal striatum after an amphetamine challenge. This thesis demonstrates how two different environmental stimuli are able to alter the neurobiology in adolescent rats. The results further support the notion that environmental conditions are of importance for normal brain maturation and provide new evidence that endogenous opioids are severely affected by social dis- turbances during adolescence. Furthermore, additional information is provided to the existing literature of how alcohol exposure during adolescence affects dopamine dynamics and drug-taking behaviour. In the literature, the majority of the studies of adolescent alcohol exposure have focused on the nucleus accum- bens, a brain area important in the processing of rewards. The results herein provide evidence that dorsal striatum, a brain area involved in the transition into habitual drug use is also affected by adolescent alco- hol exposure. An altered drug response in dorsal striatum may affect habit formation and contribute to a heightened susceptibility for high drug consumption later in life.
  •  
22.
  • Granholm, Linnea, 1986- (författare)
  • Stress, Drugs and Neuroscience : Neurobiological Effects of Social Stressors and Drug Exposure in Young and Adolescent Rats
  • 2018
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual. Three types of negative life events were studied, in an animal model, for their effects on the brain reward system (i.e., endogenous opioids and dopamine) and voluntary drug intake. These were: disruption of maternal care, disruption of interaction with peers, and exposure to drugs. Stress, in the form of maternal separation, altered expression of opioid genes in the dorsal striatum and amygdala, and the response to subsequent alcohol intake on these genes was dependent on early life conditions. Basal levels of endogenous opioids were also dependent on how the animals were housed in early adolescence. Short single housing (30 minutes) caused an acute stress response as evidenced by increased serum corticosterone and nociceptin/orphanin FQ in brain areas associated with stress. A prolonged single housing resulted in a marked decrease of Met-Enk-Arg6-Phe7 (i.e., a marker of enkephalins) in several brain areas. The endogenous opioids were also affected by repeated exposure of ethanol during adolescence; ethanol intoxication increased the accumbal levels of Met-Enk-Arg6-Phe7 and decreased those of β-endorphin. Residual effects of the adolescent ethanol exposure were found in Met-Enk-Arg6-Phe7 levels in the amygdala, ventral tegmental area, and substantia nigra. Furthermore, rats exposed to ethanol as adolescents had alterations in the dopamine dynamics in the dorsal striatum. Both endogenous opioids and dopamine are essential in mediating rewarding properties. Alterations of these systems, caused by environmental disturbances and alcohol exposure, presented herein could explain, in part, the increased susceptibility for alcohol- and substance use disorders later in life.
  •  
23.
  • Immenschuh, Jana, et al. (författare)
  • Long-term effects of early life stress on Cyp19a1 mRNA expression and DNA methylation levels in male rats
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Early life stress (ELS) raises the risk of developing mental disorders later in life by inducing lasting epigenetic changes that can impact gene expression. Aromatase, the enzyme responsible for the synthesis of estrogen, is highly expressed in the limbic brain, a key circuit in mental wellbeing. Its neuroprotective role has been investigated in relation to brain trauma but not emotional stress. The present study aimed to investigate the effect of ELS on the expression of the aromatase gene (Cyp19a1), and whether a relation can be observed with the methylation of the gene, in the limbic brain of young adult male rats. ELS was modelled by daily maternal separation for 360 minutes (MS360) in the first three postnatal weeks and compared to a control group (MS15). Cyp19a1 mRNA levels in the cingulate cortex (CCX), medial prefrontal cortex (mPFC), hypothalamus, hippocampus, and amygdala, were quantified by real-time qPCR. Additionally, CpG methylation levels in the Cyp19a1 gene were assessed via targeted next generation bisulfite sequencing. Lower levels of Cyp19a1 were found in the mPFC in MS360 rats compared to MS15, while the opposite trend was observed in the amygdala. Additionally, higher methylation levels were observed in CpGs of intron 2 in the mPFC of MS360 compared with MS15 rats. The methylation levels of intron 2 were negatively correlated with gene expression in the mPFC of MS15 rats, while the correlation was positive for MS360 rats. These findings suggest that ELS might exert a region-specific, long-term effect on both gene expression and methylation of Cyp19a1, especially in the mPFC, a key regions in stress response regulation.
  •  
24.
  • Johnston, S. Claiborne, et al. (författare)
  • Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack
  • 2021
  • Ingår i: Stroke. - : Wolters Kluwer. - 0039-2499 .- 1524-4628. ; 52:11, s. 3482-3489
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and Purpose: In patients with acute mild-moderate ischemic stroke or high-risk transient ischemic attack, the THALES trial (Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and Aspirin for Prevention of Stroke and Death) demonstrated that when added to aspirin, ticagrelor reduced stroke or death but increased risk of severe hemorrhage compared with placebo. The primary efficacy outcome of THALES included hemorrhagic stroke and death, events also counted in the primary safety outcome. We sought to disentangle risk and benefit, assess their relative impact, and attempt to identify subgroups with disproportionate risk or benefit. Methods: In a randomized, placebo-controlled, double-blind trial of patients with mild-to-moderate acute noncardioembolic ischemic stroke or high-risk transient ischemic attack, patients were randomized within 24 hours after symptom onset to a 30-day regimen of either ticagrelor plus aspirin or matching placebo plus aspirin. For the present analyses, we defined the efficacy outcome, major ischemic events, as the composite of ischemic stroke or nonhemorrhagic death, and defined the safety outcome, major hemorrhage, as intracranial hemorrhage or hemorrhagic death. Net clinical impact was defined as the combination of these 2 end points. Results: In 11 016 patients (5523 ticagrelor-aspirin and 5493 aspirin), a major ischemic event occurred in 294 patients (5.3%) in the ticagrelor-aspirin group and in 359 patients (6.5%) in the aspirin group (absolute risk reduction 1.19% [95% CI, 0.31%-2.07%]). Major hemorrhage occurred in 22 patients (0.4%) in the ticagrelor-aspirin group and 6 patients (0.1%) in the aspirin group (absolute risk increase 0.29% [95% CI, 0.10%-0.48%]). Net clinical impact favored ticagrelor-aspirin (absolute risk reduction 0.97% [95% CI, 0.08%-1.87%]). Findings were similar when different thresholds for disability were applied and over a range of predefined subgroups. Conclusions: In patients with mild-moderate ischemic stroke or high-risk transient ischemic attack, ischemic benefits of 30-day treatment with ticagrelor-aspirin outweigh risks of hemorrhage. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03354429.
  •  
25.
  • Kozarewa, Iwanka, et al. (författare)
  • Alteration of PHYA expression change circadian rhythms and timing of bud set in Populus
  • 2010
  • Ingår i: Plant Molecular Biology. - : Springer Science and Business Media LLC. - 0167-4412 .- 1573-5028. ; 73:1-2, s. 143-56
  • Tidskriftsartikel (refereegranskat)abstract
    • In many temperate woody species, dormancy is induced by short photoperiods. Earlier studies have shown that the photoreceptor phytochrome A (phyA) promotes growth. Specifically, Populus plants that over-express the oat PHYA gene (oatPHYAox) show daylength-independent growth and do not become dormant. However, we show that oatPHYAox plants could be induced to set bud and become cold hardy by exposure to a shorter, non-24 h diurnal cycle that significantly alters the relative position between endogenous rhythms and perceived light/dark cycles. Furthermore, we describe studies in which the expression of endogenous Populus tremula x P. tremuloides PHYTOCHROME A (PttPHYA) was reduced in Populus trees by antisense inhibition. The antisense plants showed altered photoperiodic requirements, resulting in earlier growth cessation and bud formation in response to daylength shortening, an effect that was explained by an altered innate period that leads to phase changes of clock-associated genes such as PttCO2. Moreover, gene expression studies following far-red light pulses show a phyA-mediated repression of PttLHY1 and an induction of PttFKF1 and PttFT. We conclude that the level of PttPHYA expression strongly influences seasonally regulated growth in Populus and is central to co-ordination between internal clock-regulated rhythms and external light/dark cycles through its dual effect on the pace of clock rhythms and in light signaling.
  •  
26.
  • Landgren, Ellen, et al. (författare)
  • Belonging, happiness, freedom and empowerment - a qualitative study of patients' understanding of health in early rheumatoid arthritis
  • 2024
  • Ingår i: BMC Rheumatology. - London : Springer Nature. - 2520-1026. ; 8:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease, that influences patients’ health in different ways, including physical, social, emotional, and psychological aspects. The goal of rheumatology care is to achieve optimal health and personalised care and therefore, it is essential to understand what health means for patients in the early course of RA. The aim of this study was to describe the understanding of health among patients with early RA.Methods: The study had a descriptive qualitative design with a phenomenographic approach. Phenomenography is used to analyse, describe, and understand various ways people understand or experience a phenomenon, in this study, patients’ understandings of health. Individual semi-structured interviews were conducted with 31 patients (22 women and nine men, aged (38–80) with early RA, defined as a disease duration of < 1 year, and disease-modifying anti-rheumatic drugs (DMARDs) for 3–7 months. The phenomenographic analysis was conducted in 7 steps, and the outcome space presents the variation in understanding and the interrelation among categories. In accordance with the European Alliance of Associations for Rheumatology’s (EULAR) recommendations, a patient research partner participated in all phases of the study.Results: The analysis revealed four main descriptive categories: ‘Health as belonging’ was described as experiencing a sense of coherence. ‘Health as happiness’ was understood as feeling joy in everyday life. ‘Health as freedom’ was understood as feeling independent. ‘Health as empowerment’ was understood as feeling capable. Essential health aspects in early RA are comprised of a sense of coherence, joy, independence, and the capability to manage everyday life.Conclusions: This study revealed that patients’ perception of health in early RA encompasses various facets, including a sense of belonging, happiness, freedom, and empowerment. It highlighted that health is multifaceted and personal, emphasizing the importance of acknowledging this diversity in providing person-centred care. The findings can guide healthcare professionals to deepen patients’ participation in treatment goals, which may lead to better treatment adherence and health outcomes.  © The Author(s) 2024.
  •  
27.
  • Landgren, Ellen, et al. (författare)
  • “Mastering a New Life Situation” – Patients’ Preferences of Treatment Outcomes in Early Rheumatoid Arthritis – A Longitudinal Qualitative Study
  • 2020
  • Ingår i: Patient Preference and Adherence. - : Dove Medical Press Ltd.. - 1177-889X. ; 14, s. 1421-1433
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To explore patients’ preferred treatment outcomes during their first two years with rheumatoid arthritis (RA). Patients and Methods: A qualitative, longitudinal, multicenter study with interviews at two time points was performed in Sweden. Individual interviews were conducted at time point 1 with 31 patients with RA, defined as disease duration of ≤1 year and treatment for 3–7 months. Seven focus group interviews and five individual interviews were conducted at time point 2 with 22 patients 12–20 months after treatment initiation. The interviews were analyzed using the Qualitative Analysis Guide of Leuven. A core category with four related concepts emerged. Results: The core finding of patient-preferred treatment outcomes was “mastering a new life situation”. Patients preferred to experience control of the disease by controlling the symptoms and by experiencing absence of disease. To experience autonomy by regaining former activity level, experiencing independence, and being empowered was another preferred outcome. Patients preferred to regain identity through being able to participate, experience well-being, and regain former self-image. To experience joy in everyday life through vitality and believing in the future was another preferred outcome. Patients’ preferences developed over time from the acute phase of controlling the symptoms and wanting to return to the life they lived prior to diagnosis, to a more preventive way of self-management and empower-ment to master the new life situation. Conclusion: The patients’ preferred treatment outcomes during the first two years with RA were to master their new life situation and changed from a preference to return to a life lived prior disease onset, to a preference of living with quality of life, despite RA. This study increases the understanding of patients’ preferred treatment outcomes in the early disease course and can be a foundation for tailoring interventions to be more person-centered and to improve long-term treatment outcomes. © 2020 Landgren et al.
  •  
28.
  • Landgren, Ellen, et al. (författare)
  • Patients’ Perceptions of Person‐Centered Care in Early Rheumatoid Arthritis : A Qualitative Study
  • 2021
  • Ingår i: ACR Open Rheumatology. - Hoboken, NJ : John Wiley & Sons. - 2578-5745. ; 3:11, s. 788-795
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Most research on patient experiences of rheumatoid arthritis (RA) care is performed with patients who have established RA and less often with patients with early RA. Experiences of and expectations about health care may change over time, which is why the aim was to explore patients’ perceptions of person-centered care (PCC) early in the RA disease course.Methods: Thirty-one patients with early RA were interviewed in this qualitative study. An abductive qualitative content analysis was conducted based on the framework of McCormack and McCance (1,2). The four constructs, prerequisites, care environment, person-centered processes, and person-centered outcomes, constituted the four categories in the deductive part of the study. An inductive analysis generated 11 subcategories exploring the content of PCC.Results: For patients with early RA, PCC was described in terms of 1) prerequisites including being treated with respect, meeting dedicated health care professionals, and meeting professional competence; 2) care environment including having access to a multidisciplinary team, having access to health care, and encountering a supportive organization; 3) person-centered processes including being listened to, being supported, and being involved in decision-making; and 4) person-centered outcomes including being satisfied with received health care and achieving optimal health.Conclusion: Genuine PCC is important for patients early in the RA disease course, supporting the implementation of a person-centered approach during all stages in the health care system. This study contributes to information about how to further develop person-centeredness in rheumatology care. © 2021 The Authors.
  •  
29.
  • Lange, Maria, et al. (författare)
  • För lite hemkunskap ökar risken för matförgiftningar
  • 2017
  • Ingår i: Dagens Nyheter. - Stockholm : AB Dagens nyheter. - 1101-2447. ; Tisdag 15 augusti, s. 6-6
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • DN.DebattRunt 500 000 människor drabbas enligt beräkningar av matförgiftning i Sverige varje år. Bristande hygienkunskaper i hushållen är en av orsakerna. Nu är det dags för en utökad timplan i hemkunskap för att Sverige skall få medvetna konsumenter, minskat matsvinn och färre fall av matförgiftningar, skriver en grupp experter inom området.
  •  
30.
  • Larsson, Ingrid, 1968-, et al. (författare)
  • Patients’ experiences of living with RA after 1-2 years of DMARD treatment
  • 2022
  • Ingår i: Reumabulletinen. - Stockholm : Svensk reumatologisk förening. - 2000-2246 .- 2001-8061. ; 154:4, s. 66-67
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Rheumatoid arthritis (RA) is a disease with a great impact on all aspects of life. Living with RA affects patients’ health including physical, emotional, psychological, and social aspects. Patients with RA are treated with disease-modifying anti-rheumatic drugs (DMARDs) and monitored with tight control to achieve low disease activity or remission. Nevertheless, RA can be life-changing when the patients need long-term treatment to control the disease activity. The goal of treatment for patients with chronic diseases such as RA is to achieve optimal health and a life as normal as possible. It is therefore important to gain knowledge about how patients experience everyday life a short period after the initiation of DMARD treatment. Aim: To describe patients’ experiences of living with RA after 1-2 years of DMARD treatment.Methods: The study has a qualitative design with an inductive approach. Focus groups (n=17) and individual (n=5) interviews were conducted with 22 patients with RA. The participants consisted of 15 women and 7 men with a mean age of 57 years and a disease duration of 12-21 months. The participants were treated with conventional or biological DMARDS for 12-20 months. The main questions were: “Can you tell me how RA impacts your daily life?” “Which outcomes of your RA are important to you at this moment?“ The interviews were analyzed with qualitative content analysis and five categories with an overarching theme emerged (Table 1).Results: Patients’ experiences of living with RA after 1-2 years of DMARD treatment lead to new insights into life and were expressed as 1) Surrendering to disease limitations due to being restricted by pain, fatigue, and in function; 2) Adapting to disease limitations by adjusting one´s work balance and one’s social life; 3) Transitioning in self-identity due to disease limitations by not recognising oneself and experiencing a change of bodily appearance and mood; 4) Fighting disease limitations by experiencing joy through exercise, promoting health by exercise and dietary habits, and; 5) Feeling humility despite disease limitations by being grateful for the treatment and seizing the day.Conclusions: Despite the fact that patients have been living with RA and treated with DMARD for 1-2 years, they are still struggling to make everyday life work. Although patients adapt their lives to the new conditions, their lives are affected by symptoms such as fatigue, pain, stiffness, and side effects such as nausea, hair loss, and weight gain. However, patients highlight the positive effects of how exercise influences their health and how living with RA leads to new insights into life.
  •  
31.
  • Lindman, Björn, et al. (författare)
  • Polyelectrolyte-surfactant association-from fundamentals to applications
  • 2014
  • Ingår i: Colloid Journal of the Russian Academy of Science. - 1608-3067. ; 76:5, s. 585-594
  • Tidskriftsartikel (refereegranskat)abstract
    • Mixed polymer-surfactant systems have broad applications, ranging from detergents, paints, pharmaceutical, and cosmetic to biotechnological. A review of the underlying polymer-surfactant association in bulk is given. While ionic surfactants bind broadly to polymers, nonionics only do so if the polymer has a lower polarity and can interact by hydrophobic interactions. Water-soluble polymers, which have hydrophobic groups, form physical cross-links, hence they may be used as thickeners. The rheological behaviour is strongly influenced by various cosolutes; especially strong effects are due to surfactants and both a decrease and an increase in viscosity can occur. When the polymer-surfactant interactions are particularly strong, an associative phase separation can occur, like in the case where there is electrostatic attraction as well as hydrophobic; this and other types of phase separation phenomena are described. Except for linear ionic and nonionic polymers, the interactions between surfactants and cross-linked polymers, microgel particles and covalent macroscopic gels are analyzed, as well as the possibility of forming gel particles of interest for encapsulation purposes. Furthermore, the behavior of these mixed systems on surfaces is discussed. In particular, we consider the adsorption of mixtures of ionic polymers and oppositely charged surfactants on polar and nonpolar surfaces. Depending on concentration, an ionic surfactant can either induce additional polyion adsorption or induce desorption. Kinetic control of adsorption and, in particular, desorption is typical. Important consequences of this include an increased adsorption on rinsing and path dependent adsorbed layers. Recently, considerable attention has been given to the interaction between DNA and cationic surfactant, both as a means to understand the behaviour of DNA in biological systems and to develop novel formulations, for example for gene therapy. Here we review aspects such as DNA compaction, DNA covalent gels and DNA soft nanoparticles.
  •  
32.
  • Lu, Qi, et al. (författare)
  • A Multi-objective Design Optimization of a Centrifugal Cooling Fan on a TEFC Motor
  • 2017
  • Ingår i: Mechanism And Machine Science. - Singapore : Springer. - 9789811028755 - 9789811028748 ; , s. 1355-1364
  • Konferensbidrag (refereegranskat)abstract
    • A design optimization method of a centrifugal fan on a totally-enclosed fan-cooled (TEFC) motor was studied in this paper. A multi-objective optimization problem was formulated which is to decrease noise level of fan and to increase air flow rate at the same time. Two design variables, namely fan diameter (D) and blade height (H), were investigated. Responses surface models were established based on design of experiments to identify the mathematical relationships between fan performances and the design parameters. These models were later used in optimization. As a result, a Pareto front was obtained which illustrated the optimal trade-offs that can be achieved in design. The Pareto front was then experimentally verified on an in-house test rig by using acoustic holography techniques.
  •  
33.
  • Mortazavi, Susanne E., et al. (författare)
  • Acquisition of complement fixing antibodies targeting Plasmodium falciparum merozoites in infants and their mothers in Uganda
  • 2023
  • Ingår i: Frontiers in Immunology. - 1664-3224. ; 14
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Antibody-mediated complement fixation has previously been associated with protection against malaria in naturally acquired immunity. However, the process of early-life development of complement-fixing antibodies in infants, both in comparison to their respective mothers and to other immune parameters, remains less clear. Results: We measured complement-fixing antibodies in newborns and their mothers in a malaria endemic area over 5 years follow-up and found that infants’ complement-fixing antibody levels were highest at birth, decreased until six months, then increased progressively until they were similar to birth at five years. Infants with high levels at birth experienced a faster decay of complement-fixing antibodies but showed similar levels to the low response group of newborns thereafter. No difference was observed in antibody levels between infant cord blood and mothers at delivery. The same result was found when categorized into high and low response groups, indicating placental transfer of antibodies. Complement-fixing antibodies were positively correlated with total schizont-specific IgG and IgM levels in mothers and infants at several time points. At nine months, complement-fixing antibodies were negatively correlated with total B cell frequency and osteopontin concentrations in the infants, while positively correlated with atypical memory B cells and P. falciparum-positive atypical memory B cells. Conclusion: This study indicates that complement-fixing antibodies against P. falciparum merozoites are produced in the mothers and placentally-transferred, and they are acquired in infants over time during the first years of life. Understanding early life immune responses is crucial for developing a functional, long lasting malaria vaccine.
  •  
34.
  • Nilsson, Maria, et al. (författare)
  • Self-Disorders in Asperger Syndrome Compared to Schizotypal Disorder : A Clinical Study
  • 2020
  • Ingår i: Schizophrenia Bulletin. - : Oxford University Press (OUP). - 1745-1701 .- 0586-7614. ; 46:1, s. 121-129
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: There are historical and theoretical indications of a difference in subjective experience between autism spectrum disorder (ASD) and the schizophrenia spectrum. However, this difference has not been empirically explored. Therefore, to explore potential differences in subjective experience between the 2 spectra, we examined the presence/absence of self-disorders in Asperger syndrome/autism spectrum disorder (As/ASD) compared to schizotypal disorder (Sd). Self-disorders represent changes in basic self-awareness which have been found to accumulate within the schizophrenia spectrum. METHODS: All participants were recruited from clinical units and interviewed with a focus on the exploration of presence/absence of self-disorders, with the Examination of Anomalous Self-Experience (EASE) scale, and a general assessment of present psychopathology, with Schedules for Clinical Assessment in Neuropsychiatry (SCAN). RESULTS: A total of 51 participants (As/ASD, n = 22; Sd, n = 29) were included in the statistical analyses. When controlling for age, gender, years of education, mental problems before the age of 16, and special needs school attendance, there was a clear difference in presence/absence of self-disorders between the 2 groups, with significantly higher levels in the Sd group. Further, there was an overlap in SCAN-rated symptoms between the 2 groups. CONCLUSION: Our results indicate a significant difference between As/ASD and Sd at the level of the basic self, which, in turn, indicates that an exploration of anomalous self-experience is a valuable supplement in the clinical differentiation between As/ASD and Sd.
  •  
35.
  • Nylander, Ingrid, 1957-, et al. (författare)
  • Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans
  • 2017
  • Ingår i: Molecular Neurobiology. - : Humana Press. - 0893-7648 .- 1559-1182. ; 54:8, s. 6225-6234
  • Tidskriftsartikel (refereegranskat)abstract
    • Alcohol misuse has been linked to dysregulation of stress, emotion, and reward brain circuitries. A candidate key mediator of this association is the FK506-binding protein (FKBP5), a negative regulator of the glucocorticoid receptor. The aim of the present study was to further understand the Fkbp5/FKBP5-related genetic underpinnings underlying the relationship between early life social relations and alcohol drinking. The effect of maternal separation and voluntary alcohol drinking on Fkbp5 expression was investigated in the brain of young adult rats, whereas the interaction effect of the functional FKBP5 single nucleotide polymorphism rs1360780 genotype and parent-child relationship on problematic drinking was examined in young adult humans. In rats, Fkbp5 expression in the nucleus accumbens and ventral tegmental area, core regions of the reward system, was affected in a region-dependent manner and in opposite direction by maternal separation and alcohol drinking. Fkbp5 expression in the cingulate cortex was affected by the combined effect of maternal separation and alcohol drinking. In humans, the TT genotype, in the presence of a poor relationship between the child and parents, was associated with problematic drinking behavior. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking. These findings are the first to point to a role of FKBP5 in propensity to alcohol misuse and call for studies of the underlying molecular mechanisms to identify potential drug targets.
  •  
36.
  • Nylander, Lena, et al. (författare)
  • ADHD in adult psychiatry. Minimum rates and clinical presentation in general psychiatry outpatients.
  • 2009
  • Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 63:1, s. 64-71
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of the study was to determine the prevalence and comorbidity of persisting attention-deficit hyperactivity disorder (ADHD) in adult psychiatric outpatients. Consecutive patients, first visits excluded, at a general psychiatric outpatient clinic were offered a screening for childhood ADHD with the Wender Utah Rating Scale (WURS). One hundred and forty-one patients out of 398 (35%) completed and returned the scale. Patients above or near cut-off for ADHD (n=57) were offered an extensive clinical evaluation with psychiatric as well as neuropsychological examination. The attrition was analysed regarding age, sex and clinical diagnoses. Out of the screened sample, 40% had scores indicating possible childhood ADHD. These 57 patients were invited to the clinical part of the study, but 10 declined assessment, leaving 47 (37 women and 10 men) who were actually examined. Thirty of these (21 women and nine men) met diagnostic criteria for ADHD at the time of examination. Among the patients with ADHD, affective disorders were the most common psychiatric diagnoses. The rate of alcohol and/or substance abuse, as noted in the medical records, was also high in the ADHD group. In the WURS-screened group, 22% (30 patients assessed as part of this study and one person with ADHD previously clinically diagnosed) were shown to have persisting ADHD. Therefore, it is clearly relevant for psychiatrists working in general adult psychiatry to have ADHD in mind as a diagnostic option, either as the patient's main problem or as a functional impairment predisposing for other psychiatric disorders.
  •  
37.
  • Nylander, Lena, et al. (författare)
  • Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in adult psychiatry. A 20-year register study.
  • 2013
  • Ingår i: Nordic journal of psychiatry. - : Informa UK Limited. - 1502-4725 .- 0803-9488. ; 67:5, s. 344-350
  • Tidskriftsartikel (refereegranskat)abstract
    • Nylander L, Holmqvist M, Gustafson L, Gillberg C. Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in adult psychiatry. A 20-year register study. Nord J Psychiatry 2012;Early Online:1-7 Objective: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are increasingly recognized in adults. This study aimed to assess trends in diagnostic practice, diagnostic delay and comorbidity regarding ADHD and ASD in adult psychiatric patients. Methods: Individuals with diagnosed ADHD or ASD were identified in an adult psychiatry register comprising 56,462 patients. Results: ADHD was diagnosed in up to 2.7% and ASD in 1.3% of the patients. Most cases were diagnosed within 2 years of first contact with adult psychiatry, but some patients were treated for 10 years or more before being diagnosed with ADHD or ASD. Seventy per cent of ADHD and 56% of ASD patients were treated as outpatients only. Other psychiatric diagnoses were registered in about 60%. Affective disorders were common in patients with ADHD. Psychoses and intellectual disability were more common in ASD patients. Psychoactive substance use-related disorders were considerably more common in those with ADHD. Concomitant ADHD and ASD were seldom diagnosed in this clinical material. Conclusion: ADHD and ASD were probably much underdiagnosed in the studied group of psychiatric patients. Other psychiatric diagnoses were common, but not ADHD with concomitant ASD.
  •  
38.
  • Nylander, Lena, et al. (författare)
  • Autism spectrum disorders and schizophrenia spectrum disorders in adults - Is there a connection? : A literature review and some suggestions for future clinical research
  • 2008
  • Ingår i: Clinical Neuropsychiatry. - Rom : Giovanni Fioriti Editore. - 1724-4935. ; 5:1, s. 43-54
  • Forskningsöversikt (refereegranskat)abstract
    • Since autism was first described, there has been an ongoing discussion concerning the connections, if any, with schizophrenia. Once thought to be the same disorder, autistic disorder and childhood schizophrenia were in the 1970s shown to be distinguishable by symptomatology and age of onset. However, as the concept of autism spectrum disorders (ASD) as well as that of schizophrenia spectrum disorders have evolved, the distinction has become less clear. To begin with the increased frequency of ASD diagnosed in adults of normal intelligence has brought up the issue of possible comorbidily of ASD and psychoses. Second, in the schizophrenia research field, it has become clear that schizophrenia is a neurodevelopmental disorder, implying that a liability may be manifested by developmental delays or abnormalities appearing in early childhood. Thus, as neurodevelopmental markers for adult schizophrenia have become better known, it seems reasonable to speculate that ASD may be among several such vulnerability factors. Finally, autistic symptoms in adults and some non-psychotic symptoms of schizophrenia are not always easily distinguishable. Cognitive impairments, deficit symptoms and motor symptoms including catatonia may be features of ASD as well as of schizophrenia. Until we have reliable biological markers for psychiatric syndromes, differential diagnosis between ASD, particularly in patients of normal intelligence, and psychoses, particularly some variants within the schizophrenia spectrum, will remain difficult. A further confounding factor is the possibility of comorbidity. More studies are needed, preferably as collaborative efforts between adult psychiatry and child and adolescent psychiatry.
  •  
39.
  • Nylander, Lena, et al. (författare)
  • Is it possible to measure the impact of a developmental disorder diagnosis received in adulthood? An attempt at follow-up and discussion of difficulties encountered in the process.
  • 2010
  • Ingår i: Clinical Audit. ; 2, s. 127-136
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Assessment of patients’ and their significant others’ (SOs’) views of receiving a diagnosis of a developmental disorder, namely attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), or Tourette’s syndrome (TS), in adulthood. Method: One to three years after clinical examination and diagnosis, a questionnaire was sent to 225 consecutive patients. Results: One hundred twenty-one patients responded (53.7%). The number of ASD patients in contact with habilitation services and with independent living had increased, as also had the number of ADHD patients receiving medication. The patients and SO expressed satisfaction with the diagnostic process. Conclusion: ADHD or ASD diagnoses received in adulthood did not, in the patients’ opinion, have a great impact in a 1- to 3-year perspective. However, since a large number of the responding patients as well as SOs were positive to the examination as such, it is suggested that the so-called neuropsychiatric diagnostic procedure may lead to rapport and thus understanding of psychiatric patients, irrespective of diagnosis. The low number of respondents is an indication that mailed questionnaires may not be the optimal method to follow-up the impact of the developmental disorder diagnosis in these patients. There are also difficulties regarding the choice of a relevant control group and regarding measurement of patients’ opinions. Significant outcomes: According to the patients themselves, rather small changes were brought about by receiving an ADHD or ASD diagnosis in adulthood. Patients who were assigned an ADHD or ASD diagnosis were more satisfied with the diagnostic procedure and its consequences than the reference group, consisting of patients who were examined, but did not meet the criteria for an ADHD, ASD, or TS diagnosis. Patients and SOs had a positive view of the assessment procedure. Limitations: Forty-six percent of the included patients did not respond. The reference group was a diagnostically heterogeneous group of patients, most of whom had severe mental disor- ders. The availability of services may be a confounding factor, influencing the patients’ views of the present situation and the benefit of the diagnosis. There was no questionnaire given to the patients at baseline, and the mailed questionnaire had not been validated. Considering that every patient or SO answered several questions, the differences at P = 0.05 may not actually be significant if corrected for multiple comparisons.
  •  
40.
  • Nylander, Maria (författare)
  • G835P Defekter i pressgjutgods – kolvsmörjmedel
  • 2012
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Rapporten beskriver resultaten från försök hos två gjuterier. Försöken vill visa hur typ och mängd av kolvsmörjmedel påverkar gjutgodskvalitén. Hos Ljunghälls gjordes försök med både olja och granulat på samma komponent. Materialundersökningen visar något spridda resultat när det gäller defekterna. Försöken med olja gav några komponenter med relativt mycket porositeter redan vid normala mängder, medan försöken med granulat gav genomgående lägre porhalter. Hos Lundbergs pressgjuteri, där enbart olja används, gjordes försök på en tunnväggig komponent. Där ses genomgående en relativt stor skillnad i porhalt mellan de olika doseringsnivåerna, särskilt i området nära inloppet. I området längst från inloppet jämfördes även tunnare och tjockare sektioner. I detta område hade godstjockleken större betydelse för porhalten än smörjmedlets dosering. SEM-undersökningen av Lundbergs komponent visar att kolhalten i ytorna varierar beroende på smörjmedelsdosering. Då doseringen ökade, fördubblades mängden kol i godsytan. Det observerades även fläckar med mycket hög kolhalt både vid hög och vid normal dosering. Samtal med leverantörer visar att utvecklingen när det gäller kolvsmörjmedel går mot de högkoncentrerade oljorna. Anledningen är att man sett betydande förbättringar när det gäller livslängden på kolvar och kolvringar, samt att den mycket låga doseringen bidrar till minskade defekter i godset.
  •  
41.
  • Nylander, Maria (författare)
  • G882P – Strukturmetaller
  • 2014
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • I rapporten har sammanställts material kring ett urval av de aluminiumlegeringar som kallas strukturlegeringar. Gemensamt för dessa legeringar är att de har goda mekaniska egenskaper och då framförallt en hög brottförlängning, mer än 10-12 %. Utvecklingsarbetet kring dessa legeringar har till stor del skett i Tyskland och i nära samarbete med bilindustrin. En av de kändare strukturlegeringarna som beskrivs mer detaljerat i rapporten är Silafont-36, AlSi9MgMn, från Rheinfelden. En annan, som också beskrivs, är Aural-2®, AlSi10MgMnFe, från Rio Tinto Alcan. De är framställda från primäraluminium. Arbete pågår även med att ta fram högpresterande, duktila, aluminiumlegeringar från återvunnen metall. Ännu så länge har det varit svårt att uppnå samma renhet i återvunna legeringar, men det finns idag tekniker med saltbadsugnar som renar smältan mycket effektivt från föroreningar. Det är just föroreningarna, och då främst Fe, som är det stora hotet mot materialets brottförlängning. En förutsättning för att styra Al-Si-Mglegeringarnas mekaniska egenskaper är att de måste vara värmebehandlingsbara. De måste därför gjutas på ett mycket omsorgsfullt sätt, t.ex. med vakuum, för att minimera halten av innesluten luft. Behovs- och framtidanalys för Europas räkning kring strukturmetaller, har inte varit tillgänglig i använda källor. Statistiken har visat en något nedåtgående trend för framställningen av traditionellt pressgjutgods av aluminium, och även för fordonsproduktion. För trender i USA har det dock funnits en del källor att tillgå, vilka pekar på en uppgång.
  •  
42.
  • Nylander, Maria (författare)
  • G914M Trycktäta gjutgods – Si-legerad mässing
  • 2015
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Försök har genomförts för att jämföra kornförfiningseffekten av Zr-haltigt preparat med de traditionella B-haltiga preparaten hos den blyfria mässingslegeringen Cuphin. Cuphin är legerad med Si, cirka 3 %, för att uppnå en god skärbarhet. En provkokill i koppar tillverkades för försöken. Kokillens geometri utformades så att den skulle innehålla avsnitt som skulle vara särskilt utsatta för krympning och varmsprickor. För att undersöka effekten av kornförfining på dessa defekter gjordes gjutförsök i olika omgångar, med tillsatser av CuZr4 i fem nivåer samt CuB2 i två nivåer. Försöken visar att en god kornförfining uppnås med det Zr-haltiga preparatet, men att det krävs 20-40 ppm Zr. Preparatet klingar av mycket snabbt, på cirka 20-30 minuter. Med B-haltigt preparat uppnås ingen synbar kornförfining i de nivåer som testades, d.v.s. upp till de nivåer som normalt används vid kornförfining av blyhaltiga legeringar. Vid undersökning av provkropparna i stereomikroskop sågs inte några säkerställda skillnader i sprickbildning mellan de olika provomgångarna. Alla proven fick en större sjunkning vid en stor godsanhopning, men i de radier som det förväntades att sprickbildning skulle ske sågs inga sådana tendenser i något av materialen. Krympsprickor och porer var, totalt sett, mest uttalat i de ej kornförfinade proven, men hos proven som kornförfinats fanns en spridning av sprickor och porer även inom provgrupperna.
  •  
43.
  •  
44.
  •  
45.
  •  
46.
  • Nylander, Ola, 1957, et al. (författare)
  • Filmstaden - erfarenheter av ett bostadsprojekt
  • 2007
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Filmstaden är en ny stadsdel som växer fram i norra Solna. Ut¬byggnaden sker på klassisk mark, där SF, från 1920-talet fram till slutet av 1960-talet, producerade film.Brunnberg & Forshed arkitektkontor fick 1996 i uppdrag att utreda möjligheterna till bostadsbebyggelse i Filmstaden. Kv Kasematten, med 85 lägenheter, är det första kvarteret i nya Filmstaden. Inflyttningen inleddes 2005. Filmstaden är ett bostadsprojekt som vi på Brunnberg & Fors¬hed arkitektkontor är stolta över. Det är ett projekt med hög målsättning och där vi haft många idéer om arkitekturens roll för upplevelsen av stadsmässighet och som värdeskapare. När Kv Kasematten stod klart var vi därför intresserade av hur våra idéer och ansträngningar för att skapa bra bostäder tagits emot av de som fl yttade in. Vi sammanfattade våra frågor i tre övergripande frågeställningar:• Stadsmässighet - vilka egenskaper måste finnas?• Varierar bostadens kvalitet med boende kostnaden?• Vilka arkitektoniska kvaliteter är viktiga för de boende?I undersökningen intervjuades 12 familjer och en enkät med 15 frågor skickades ut till samtliga boende i kvarteret. Vi har fått in svar från drygt 2/3 av de boende.Vi har mött övervägande nöjda boende. Arkitekturen är viktig för de boende. På vår sammanfattande fråga om den yttre miljön, fasader, gård och stadsmässighet fick vi exempelvis enbart positiva svar.
  •  
47.
  •  
48.
  • Nylander, Tommy, et al. (författare)
  • Relationship between Structure and Fluctuations of Lipid Nonlamellar Phases Deposited at the Solid-Liquid Interface
  • 2017
  • Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 121:13, s. 2705-2711
  • Tidskriftsartikel (refereegranskat)abstract
    • The structure and dynamics of nanostructure films formed by mixtures of soy phosphatidylcholine and glycerol dioleate at the silicon aqueous interface were studied by grazing incidence neutron spin echo spectroscopy (GINSES), specular and off-specular neutron, reflectometry, and small-angle X-ray diffraction. Reverse hexagonal (Hr) and micellar cubic phase (Fd3m) layers at: the solid liquid interface have been identified with neutron reflectometry measurements. A preferred orientation of the liquid crystalline (LC) domains was observed only for the anisotropic,H-II phase. The size of the LC domains was found to be about 1 micrometer as estimated from the width of the diffraction peaks. GINSES revealed that the cubic phase forms rather rigid films. In comparison, the HE film was more flexible, appearing as a modified undulation spectrum of the cylinders due to the interaction with the substrate.
  •  
49.
  • Nylander, Åsa, 1974- (författare)
  • Structural and functional studies of streptococcal surface adhesins
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The oral cavity is home to an array of microorganisms that are associated with dental plaque. Some Gram-positive bacteria are common inhabitants of the oral cavity and in order to colonize such a unique environment adhesion becomes essential and is accomplish by adhesins expressed on the bacterial surface. Adhesins can interact with host molecules or with structures on the resident oral microbial flora. Members of the antigen I/II (AgI/II) protein family are commonly found on the surface of oral streptococci and have the unique feature that their putative adhesin domain is located in the centre of the primary sequence. Crystal structures representing parts of the C-terminal domains from two AgI/II members, SpaP from Streptococcus mutans and AspA from Streptococcus pyogenes, were determined to 2.2 and 1.8 Å resolution respectively. The structures are very similar and consist of two domains with DEv-IgG folds. The proteins are stabilized by intramolecular isopeptide bonds and tightly coordinated metal ions.Another group of surface proteins is the microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) that have their putative adhesin domain in the N-terminal, presented on a stalk formed by multiples of repeated C-terminal domains. Sgo0707 from Streptococcus gordonii is an example of this group of proteins and its N-terminal domain was determined to 2.1 Å resolution. The structure consists of two domains, N1 and N2, both of which adopt β-sandwiches. In the Sgo0707 structure no isopeptide bonds or metal ions were detected. A putative binding cleft is present in the N1 domain. Functional studies revealed collagen type-1 and keratinocytes as possible binding partners.In order to further characterize the AgI/II protein AspA from S. pyogenes a long form of the protein, AspA-AVPC, was expressed and purified. During the purification process it was observed that the protein fragmented into two major parts. This process could be inhibited by the addition of 0.5 mM EDTA during protein purification.In conclusion, these studies have resulted in adding to the knowledge of protein structures and function of streptococcal surface proteins.
  •  
50.
  • Political Discourses at the Extremes : Expressions of Populism in Romance-Speaking Countries
  • 2019
  • Samlingsverk (redaktörskap) (refereegranskat)abstract
    • The authors of this edited volume focus on the emergence of populist discourses, coming from  movements or parties from Romance-speaking countries in Europe and in Latin America. By combining  linguistics, social and political sciences in a discourse analytical approach, the sixteen papers  enlighten the mechanisms behind populist discourses yielding from different socio-cultural and  political contexts. The common denominator of the studies is the focus on the discursive and  rhetorical characteristics of recently emerged movements of populism in both continents.  Investigating expressions of these political movements is highly relevant in today’s society, where  the growing number of populist discourses has become a pre-eminent issue, alongside people’s  increasing insecurity regarding future political and environmental challenges. The primary audience  of this volume are researchers working in the fields of political discourse analysis; however, this  book may benefit anybody with interest in language in politics.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 81
Typ av publikation
tidskriftsartikel (51)
rapport (7)
konferensbidrag (6)
doktorsavhandling (5)
forskningsöversikt (3)
samlingsverk (redaktörskap) (2)
visa fler...
annan publikation (2)
bokkapitel (2)
konstnärligt arbete (1)
bok (1)
licentiatavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (48)
övrigt vetenskapligt/konstnärligt (29)
populärvet., debatt m.m. (3)
Författare/redaktör
Nylander, Tommy (22)
Comasco, Erika, 1982 ... (9)
Nylander, Ingrid (6)
Nylander, Lena (6)
Comasco, Erika (5)
Larsson, Ingrid, 196 ... (5)
visa fler...
Pálsson, Gunnar K. (3)
Gillberg, Christophe ... (3)
Fredriksson, Robert (3)
Andershed, Henrik, 1 ... (3)
Grundström, Karin (2)
Abarkan, Abdellah (2)
Andersson, Roger (2)
Baeten, Guy (2)
Clark, Eric (2)
Franzén, Mats (2)
Gabrielsson, Cathari ... (2)
Glad, Wiktoria (2)
Haas, Tigran (2)
Hellström, Björn (2)
Hellström Reimer, Ma ... (2)
Henriksson, Greger (2)
Holgersen, Ståle (2)
Kärrholm, Mattias (2)
Lindholm, Gunilla (2)
Listerborn, Carina (2)
Mack, Jennifer (2)
Magnusson, Jesper (2)
Mattsson, Helena (2)
Metzger, Jonathan (2)
Molina, Irene (2)
Nylander, Ola (2)
Nylund, Katarina (2)
Olsson, Lina (2)
Rizzo, Agatino (2)
Rohracher, Harald (2)
Salonen, Tapio (2)
Schalk, Meike (2)
Schmidt, Staffan (2)
Stenberg, Erik (2)
Stenberg, Jenny (2)
Tesfahuney, Mekonnen (2)
Urban, Susanne (2)
Werner, Inga Britt (2)
Westerdahl, Stig (2)
Holdaway, James (2)
Lindman, Björn (2)
Andershed, Anna-Kari ... (2)
Nylander, Eva (2)
Arvidsson, Susann, 1 ... (2)
visa färre...
Lärosäte
Lunds universitet (28)
Uppsala universitet (26)
Malmö universitet (14)
Högskolan i Halmstad (9)
RISE (8)
Göteborgs universitet (7)
visa fler...
Mälardalens universitet (6)
Örebro universitet (6)
Stockholms universitet (4)
Umeå universitet (3)
Linköpings universitet (3)
Kungliga Tekniska Högskolan (2)
Chalmers tekniska högskola (2)
Karolinska Institutet (2)
Luleå tekniska universitet (1)
Marie Cederschiöld högskola (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (70)
Svenska (11)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (31)
Naturvetenskap (29)
Teknik (5)
Lantbruksvetenskap (3)
Samhällsvetenskap (3)
Humaniora (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy