| 1. |
- Aggeborn, Linuz, 1986-, et al.
(författare)
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Disentangling the Impact of Civil Association Membership on Political Participation : Evidence from Swedish Panel Data
- 2021
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Ingår i: British Journal of Political Science. - : Cambridge Scholars Publishing. - 0007-1234 .- 1469-2112. ; 51:4, s. 1773-1781
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Tidskriftsartikel (refereegranskat)abstract
- What is the effect of membership in civil associations on political participation? Membership has been linked to providing social capital and personal networks, which in turn help citizens more easily navigate politics. Yet this link is empirically complex, since politically interested individuals self-select into networks and associations. This research note addresses the impact of membership on different forms of political participation using a panel survey from Sweden that distinguishes between passive and active membership in various types of associations. The baseline results reaffirm a strong association between membership and political participation. The survey's panel dimension is exploited to reveal that earlier scholarship has likely overstated the robustness of membership's participatory effects. Rather, the remaining impact of association membership in the panel specification is mainly driven by types of associations for which the highest degree of selection behaviour is expected.
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| 2. |
- Aggeborn, Linuz, 1986-, et al.
(författare)
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Intergenerational Transmission of Party Affiliation Within Political Families
- 2021
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Ingår i: Political Behavior. - : Springer Nature. - 0190-9320 .- 1573-6687. ; 43:2, s. 813-835
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the intergenerational transmission of political-party affiliation within families with at least two politicians. We use Swedish registry data that covers all nominated politicians for the years 1982 to 2014, as well as their family ties. First, we demonstrate there is a strong link between individuals and their parents concerning party affiliation. We also find that this intergenerational transmission persists over generations and across siblings. Our second aim is to investigate the mechanisms behind this result, which we do by first discussing two hypotheses: the one concerns a socialization pathway, the other a materialistic one. We then bring these hypotheses to the data, and we find that the socialization pathway matters more for intergenerational transmission.
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| 3. |
- Aggeborn, Linuz, 1986-, et al.
(författare)
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Parents, Peers, and Politics : The Long-term Effects of Vertical Social Ties
- 2020
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Ingår i: Quarterly Journal of Political Science. - : NOW PUBLISHERS INC. - 1554-0626 .- 1554-0634. ; 15:2, s. 221-253
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Tidskriftsartikel (refereegranskat)abstract
- We examine how one's adult political participation is affected by having social ties to a politician during adolescence. Specifically, we estimate the long-term effect of having had a classmate during upper secondary school whose parent was running for office on future voter turnout and the likelihood of running for and winning political office. We use unique Swedish population-wide administrative data and find that students in school classes with a larger number of politically active parents are more politically active as adults, both in terms of voting and political candidacy. Our results suggest that the effect of vertical social ties is predominantly mediated by indirect links between the politician and the student via the children of politicians. Moreover, we show that the strength of these mobilizing effects depends on the individual's basic predisposition to engage in different types of political activities.
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| 4. |
- Ahlskog, Rafael, et al.
(författare)
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The Fiscal Effects of EU Migration to Slovakia
- 2019
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Ingår i: Globe in Motion 2. - Bratislava : Institute of Ethnology and Social Anthropology, Slovak Academy of Sciences. - 9788097097592 - 9788097337209 ; , s. 46-61
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Bokkapitel (refereegranskat)
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| 5. |
- Brännlund, Anton
(författare)
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Wealth and the economic vote : How assets and liabilities shape election outcomes
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis contributes to the literature on economic voting, especially the subfield of the electoral impact in relation to wealth. The thesis consists of an introductory chapter and four independent research articles based on data from Sweden. Based on the first article, I find that the support for right-wing parties decreases in areas where voters are heavily invested in financial assets when there is a large amount of volatility in the world markets. Such patterns suggest that voters are responsive to financial risks. Through the second study, I illustrate that voters are sensitive to changes in monetary policies as well. More precisely, I show that voters tend to reward governments for decreases in interest rates. With the third study, I investigate the interplay of markets in a more direct way, estimating the effect of unemployment on voting in relation to household wealth. I find that the Swedish left-wing parties gain electoral advantage when the unemployment rates rise in less wealthy areas but that they lose support where voters are comparatively well-off. Finally, based on the fourth study, I investigate whether wealth has an impact on how voters behave with individual level data. The findings in this study suggest that wealthy citizens vote for right-wing parties to a grater extent. However, the estimated effect is small.
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| 6. |
- Cronert, Axel, 1986-, et al.
(författare)
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A General Approach to Measuring Electoral Competitiveness for Parties and Governments
- 2021
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Ingår i: Political Analysis. - : Cambridge University Press (CUP). - 1047-1987 .- 1476-4989. ; 29:3, s. 337-355
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Tidskriftsartikel (refereegranskat)abstract
- We develop a general approach to measuring electoral competitiveness for parties and governments, which is distinct from existing approaches in two ways. First, it allows us to estimate the actual probability of re-electing the incumbent into office, which lies closer to the theoretical concept of interest than most widely used proxies. Second, it incorporates both pre-electoral competitiveness—that is, the uncertainty about the outcome of the upcoming election—and post-electoral competitiveness—that is, the uncertainty concerning who will form the government given a certain election result. The approach can be applied to, and compared across, a multitude of institutional settings and is particularly advantageous in analyses of multiparty democracies. To demonstrate its full potential, we first apply the approach on 1,700 local government elections in Sweden. Three advantages over existing approaches are documented: Our election probability measure shows substantial variation over the election cycle, it can be accurately measured for a single party as well as a government, and it is more capable of predicting re-election into office than any previous measure of electoral competitiveness. A second application on 400 national elections in 34 democracies shows that the approach also works well in a more challenging cross-national setting.
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| 7. |
- Cronert, Axel, et al.
(författare)
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Do voters' biases impede future‐oriented policy‐making?
- 2024
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Ingår i: European Journal of Political Research. - 0304-4130 .- 1475-6765. ; 63:3, s. 1108-1128
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Tidskriftsartikel (refereegranskat)abstract
- In research on public economics, climate politics and the welfare state, voters' informational and cognitive biases are commonly understood as impeding future-oriented policy-making, by incentivizing policymakers to trade off long-term investments against short-term consumption when facing competitive elections or liquidity constraints. Yet, the assumptions about how policymakers perceive these alleged trade-offs have not yet been verified. This study reports results from a survey of Swedish local government politicians, centring around experiments about environmental-friendly public investments. We find that most politicians perceive that electoral competition stimulates rather than impedes investments. Politicians are, however, less supportive of investments if these need to be financed through absolute losses rather than gains foregone, which illustrates the relevance of endowment effects in long-term governance. We furthermore show that our micro-level observations are consistent with macro-level investment expenditure patterns. These findings demonstrate that accounting for policymakers' own perceptions is important for advancing our understanding of future-oriented policy-making.
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| 8. |
- Dancygier, Rafaela, et al.
(författare)
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Candidate Supply Is Not a Barrier to Immigrant Representation : A Case-Control Study
- 2021
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Ingår i: American Journal of Political Science. - : Wiley. - 0092-5853 .- 1540-5907. ; 65:3, s. 683-698
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Tidskriftsartikel (refereegranskat)abstract
- Immigrants are underrepresented in most democratic parliaments. To explain the immigrant-native representation gap, existing research emphasizes party gatekeepers and structural conditions. But a more complete account must consider the possibility that the representation gap begins at the supply stage. Are immigrants simply less interested in elected office? To test this explanation, we carried out an innovative case-control survey in Sweden. We surveyed elected politicians, candidates for local office, and residents who have not run; stratified these samples by immigrant status; and linked all respondents to local political opportunity structures. We find that differences in political ambition, interest, and efficacy do not help explain immigrants' underrepresentation. Instead, the major hurdles lie in securing a candidate nomination and being placed on an electable list position. We conclude that there is a sufficient supply of potential immigrant candidates, but immigrants' ambition is thwarted by political elites.
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| 9. |
- Egeblad, Louise, et al.
(författare)
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Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1
- 2010
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Ingår i: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 277:23, s. 4920-30
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Tidskriftsartikel (refereegranskat)abstract
- Human hypoxanthine-guanine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) catalyzes the conversion of hypoxanthine and guanine to their respective nucleoside monophosphates. Human HPRT deficiency as a result of genetic mutations is linked to both Lesch-Nyhan disease and gout. In the present study, we have characterized phosphoribosyltransferase domain containing protein 1 (PRTFDC1), a human HPRT homolog of unknown function. The PRTFDC1 structure has been determined at 1.7 Å resolution with bound GMP. The overall structure and GMP binding mode are very similar to that observed for HPRT. Using a thermal-melt assay, a nucleotide metabolome library was screened against PRTFDC1 and revealed that hypoxanthine and guanine specifically interacted with the enzyme. It was subsequently confirmed that PRTFDC1 could convert these two bases into their corresponding nucleoside monophosphate. However, the catalytic efficiency (k(cat)/K(m)) of PRTFDC1 towards hypoxanthine and guanine was only 0.26% and 0.09%, respectively, of that of HPRT. This low activity could be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT. In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base. The data obtained in the present study indicate that PRTFDC1 does not have a direct catalytic role in the nucleotide salvage pathway.
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| 10. |
- Fjordén, Karin, et al.
(författare)
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CD40 is a potential marker of favorable prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.
- 2010
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Ingår i: Leukemia & Lymphoma. - : Informa UK Limited. - 1029-2403 .- 1042-8194. ; 51, s. 1643-1648
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown that expression of CD40 has a favorable prognostic impact in diffuse large B-cell lymphoma (DLBCL) after anthracycline-based chemotherapy. Here we examined the prognostic value of immunohistochemically defined CD40 expression in 95 patients with DLBCL treated with both anthracycline-based chemotherapy and rituximab. Using a 10% cut-off level, 77% of the patients had CD40-positive tumors and showed a superior overall survival (p = 0.02 log-rank, hazard ratio 0.35, 95% CI 0.14-0.88, p = 0.03 Cox regression). When adjusted for International Prognostic Index in multivariate analysis, CD40 was not an independent prognostic factor (hazard ratio 0.39, 95% CI 0.15-1.04, p = 0.06 Cox regression). However, even after the introduction of immunochemotherapy, CD40 has a potential prognostic impact in DLBCL. Additional and larger studies are necessary, regarding the immunohistochemical robustness of CD40 and the biological mechanisms that contribute to the superior prognosis in CD40-expressing DLBCL.
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| 11. |
- Herman, Maria Dolores, et al.
(författare)
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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
- 2008
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Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 582:25-26, s. 3590-3594
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Tidskriftsartikel (refereegranskat)abstract
- Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.
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| 12. |
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| 13. |
- Häggström, Daniel, et al.
(författare)
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Predicting friction in synchronizer systems
- 2016
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Ingår i: Tribology International. - : Elsevier. - 0301-679X .- 1879-2464. ; 97, s. 89-96
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Tidskriftsartikel (refereegranskat)abstract
- The coefficient of friction in synchronizers is important from both a performance and a functional point of view. The synchronization process is highly transient, and the parameters affecting the coefficient of friction have strong mutual dependences, making analysis highly complex. A new friction model for a lubricated molybdenum-steel contact has been developed based on integrating results from physical rig tests and FEM simulations. A simplified thermal model has also been developed, with the purpose to quickly assess the coefficient of friction based on transient force and synchronizer dimensions. The results show good correlation with measured data except at very low sliding speed.
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| 14. |
- Magnusdottir, Audur, et al.
(författare)
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The structure of the PP2A regulatory subunit B56gamma : The remaining piece of the PP2A jigsaw puzzle
- 2009
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Ingår i: Proteins. - : Wiley. - 0887-3585 .- 1097-0134. ; 74:1, s. 212-221
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Tidskriftsartikel (refereegranskat)abstract
- The PP2A serine/threonine phosphatase regulates a plethora of cellular processes. In the cell the predominant form of the enzyme is a heterotrimer, formed by a core dimer composed of a catalytic and a scaffolding subunit, which assemble together with one of a range of different regulatory B subunits. Here, we present the first structure of a free non-complexed B subunit, B56. Comparison with the recent structures of a heterotrimeric complex and the core dimer reveals several significant conformational changes in the interface region between the B56 and the core dimer. These allow for an assembly scheme of the PP2A holoenzyme to be put forth where B56 first complexes with the scaffolding subunit and subsequently binds to the catalytic subunit and this induces the formation of a binding site for the invariant C-terminus of the catalytic subunit that locks in the complex as a last step of assembly.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Mäki, Rikard, et al.
(författare)
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Measurement and characterisation of anti-shudder properties in wet clutch applications
- 2005
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Ingår i: 2005 SAE world congress. - Warrendale, Pa : Society of Automotive Engineers, Incorporated. - 9780768016246
-
Konferensbidrag (refereegranskat)abstract
- Wet clutches operating under low velocity and continuous sliding are increasingly important in vehicle transmissions. This presents new challenges in improving anti-shudder properties of the clutch system. In order to determine anti-shudder properties the friction-velocity relationship is generally examined. The friction-velocity characteristics are however influenced by the way they are measured, and the measurement methods differ between different standards and OEM approvals, thus making direct comparisons of the anti-shudder requirements difficult. This study investigates how different parameters influence anti- shudder properties. Results show how the obtained friction-velocity characteristics are influenced by the choice of different test procedures and parameters. Methods for presenting the anti-shudder properties are compared for the different cases and a method for evaluation of the properties is suggested. Presenting data using the proposed method makes comparison of results obtained from different measurements easier or even possible.
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| 19. |
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| 20. |
- Nyman, Pär, 1984-
(författare)
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Austerity Politics : Is the Electorate Responsible?
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis contributes to the public finance literature concerned with fiscal sustainability, and consists of an introduction and four stand-alone essays. The first three essays analyse the reasons why governments accumulate large levels of debt. In the first essay, I find that parties that implement fiscal consolidations are punished by the voters in the following election. However, there does not appear to be a rewarding effect for governments that implement fiscal expansions. The second essay, which is co-authored with Rafael Ahlskog, shows how voter opposition to fiscal consolidation is shaped by moral considerations and feelings of personal responsibility. More precisely, we argue that voters are more likely to refuse fiscal consolidation when they do not feel responsible for the public debt. The third essay argues that misperceptions about the business cycle would have caused fiscal problems even if policy-making was conducted by independent experts. According to my estimates, biased projections have weakened annual budget balances by approximately one per cent of GDP. In the fourth essay, I argue that budgetary mechanisms created to improve fiscal discipline have a bias toward a reduced public sector. Because discretionary decisions are usually required to adjust public expenditures to price and wage increases, periods of rapid growth have repeatedly caused the welfare state to shrink. I use the introduction to discuss the commonalities between the essays and to situate the field of public finance in a broader, historical context.
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| 21. |
- Nyman, Pär, 1984-
(författare)
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Door-to-door canvassing in the European elections : Evidence from a Swedish field experiment
- 2017
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Ingår i: Electoral Studies. - : Elsevier. - 0261-3794 .- 1873-6890. ; 45, s. 110-118
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Tidskriftsartikel (refereegranskat)abstract
- In this paper I report the results from a door-to-door canvassing experiment conducted in Sweden during the 2014 European elections. The canvassing was performed by members of the Social Democratic Party and the experiment closely resembles the partisan nature of most mobilizing campaigns in Europe. The paper is one of the first to provide causal evidence for the mobilizing effectiveness of canvassing outside the United States. Living in a household that was visited by canvassers increases the probability of voting by 3.6 percentage points. This effect is entirely driven by estimates twice as large for occasional and first-time voters. Compared to previous research, the high compliance rate gives precisely estimated effects that are closer to average treatment effects.
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| 22. |
- Nyman, Pär, 1984-
(författare)
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Economic growth is deflating the welfare state
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Differences in economic growth is one of the primary explanations for why welfare state retrenchment has occurred in some countries and not others. Because public spending is only partially indexated to earnings, the welfare state shrinks as the economy prospers. Using growth data from countries with synchronized business cycles as an instrument, I demonstrate that the relationship can be interpreted as a causal effect of growth on both tax ratios and social spending.
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| 23. |
- Nyman, Pär, 1984-, et al.
(författare)
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Filling in the blanks : How does information about the Swedish EITC affect labour supply?
- 2023
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Ingår i: Labour Economics. - : Elsevier. - 0927-5371 .- 1879-1034. ; 85
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the role of information about tax incentives for the labour-leisure choice. We randomize 37,000 leaflets about the Swedish EITC, and then study the effects with pre-registered analyses and administrative data. Our focus is on the household decision to allocate between labour income and parental leave payments. The EITC and its interactions with the parental leave system is not well-known. Despite the substantial incentives involved, and the flexibility with which a person may earn labour income, we find that information about the EITC has a precisely estimated zero impact on labour supply on the extensive and the intensive margin.
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| 24. |
- Nyman, Pär, 1984-, et al.
(författare)
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Filling in the Blanks: How Does Information about the Swedish EITC Affect Labour Supply?
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Information plays a key role in economics. According to the benchmark neoclassical model, agents require information in order to optimize their choices. Information, however, is sometimes incomplete or asymmetric in the real world. In this paper, we investigate the role of information for the labour--leisure choice. We conduct an information experiment wherein we distribute a leaflet about the Swedish Earned Income Tax Credit (EITC), and then study the effects with registry data. More specifically, we focus on the household decision to allocate between labour income and parental leave payments. The EITC, it bears noting, applies to the former but not to the latter. The construction of the Swedish EITC generates a strong economic incentive to have some labour income during a calendar year, because it is tailored to benefit low labour income earners more in relative terms. Yet, despite the substantial economic incentives involved, and despite the flexibility with which a person may earn labour income, we find that providing information about the features of the EITC has zero impact on labour supply.
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| 25. |
- Nyman, Pär, 1984-, et al.
(författare)
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Hur påverkas arbetsutbudet av information om jobbskatteavdraget?
- 2022
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Rapport (populärvet., debatt m.m.)abstract
- Tillgång till information är en central aspekt i ekonomiska modeller. Genom attha tillgång till information kan individer och företag fatta ekonomiska beslut. Iverkligheten finns det dock flera tillfällen när information saknas eller därinformationen är svårbegriplig. Det svenska jobbskatteavdraget är tänkt att ökaincitamentet att arbeta där skatten sänks på arbetsinkomst men inte på andratyper av inkomst såsom ersättning från Försäkringskassan. Många svenskarkänner emellertid inte till hur jobbskatteavdraget är konstruerat i detalj. I dennarapport studerar vi hur information om jobbskatteavdraget påverkar arbetsutbudmed hjälp av svensk registerdata. Vi har genomfört ett informationsexperimentdär vi har skickat ut information om jobbskatteavdraget till föräldrar. Enförhållandevis okänd aspekt av jobbskatteavdraget är att det ger starkaekonomiska incitament att ha någon arbetsinkomst under ett kalenderår eftersomjobbskatteavdraget är riktat mot lägre inkomster. Vi finner inte några effekter avatt få information vare sig på sannolikheten att arbeta eller antalet arbetadetimmar.
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| 26. |
- Nyman, Pär, et al.
(författare)
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Influence of surface topography on friction characteristics in wet clutch applications
- 2006
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Ingår i: Wear. - : Elsevier BV. - 0043-1648 .- 1873-2577. ; 261:1, s. 46-52
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Tidskriftsartikel (refereegranskat)abstract
- In heavily loaded wet clutches, such as in limited slip differentials, sintered friction materials are sometimes used due to their resilience at high loads and high temperatures as well as their competitive cost in comparison to alternative friction materials. During the lifetime of the clutch, changes in the friction materials' topography occur. These changes will influence the friction characteristics of the clutch, and therefore affect the anti-shudder performance of the transmission system. This paper investigates the influence of, and classifies, changes in the topography of the sintered friction material. The topography is measured by utilizing vertical scanning interferometry. Different parameters are investigated in order to find relevant parameters correlating to the wear of the material. Results show that changes in the topography of the friction material do indeed influence the friction characteristics of the clutch and that it is possible to calculate relevant topography parameters that describe the amount of wear the material has been subjected to.
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| 27. |
- Nyman, Pär, 1984-, et al.
(författare)
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Not my problem: fairness and fiscal responsibility in the age of austerity
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Voter opposition to fiscal consolidation is often attributed to intergenerational exploitation, short-sightedness or lack of information. While these mechanisms are likely at play, the effect of voters' moral considerations are largely absent from the public finance literature. This study addresses the effects of blame and feelings of personal responsibility on support for budget consolidations. We argue that voters will feel less responsibility for fiscal problems originating from a crisis in the banking sector than if those problems result from a continuous accumulation of deficits, and will therefore be less supportive of austerity measures to repay the resulting debt. Our results, which make use of both cross-country data and a survey experiment, are consistent with this. Since financial crises and many other costly events are practically random, this can have the profoundly counter-intuitive consequence that governments are punished harder for things that are outside of their control.
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| 28. |
- Nyman, Pär, 1984-
(författare)
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Politics or perceptions? The fiscal consequences of uninformed policy makers
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Cross-national variations in fiscal performance have traditionally been seen as resulting from differences in electoral systems and types of government. However, such politico-institutional explanations appear to be sensitive to the time-period analysed. This paper provides a new explanation of why some countries have managed to consolidate public finances, while others have accumulated unsustainable levels of debt. Using real-time data for a panel of 31 OECD countries over the 1997-2012 period, the paper shows that governments have responded to biased economic forecasts with more expansionary fiscal policies than they would have if projections had been unbiased. The estimated effects are large. On average, biased projections have weakened annual budget balances by approximately one per cent of GDP.
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| 29. |
- Nyman, Pär, 1984-
(författare)
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Punished for austerity? The electoral consequences of fiscal adjustments
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In both economics and political science, conventional wisdom states that austerity policies are unpopular among voters, and that those governments which implement tax hikes and cutbacks in public spending will lose votes in the subsequent election. However, this claim has received little empirical support. This paper finds that parties which implement fiscal consolidations are punished by the voters in the following election, a result that goes against previous research, but one which is in line with conventional wisdom. The estimated effects are larger when the adjustments are visible and when there is a unified control of policymaking. There do not appear to be any electoral consequences for implementing fiscal expansions.
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| 30. |
- Nyman, Pär, 1984-
(författare)
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The political challenge of austerity politics
- 2018
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Ingår i: Bridging the Prosperity Gap in the EU. - Cheltenham : Edward Elgar Publishing. - 978 1 78643 666 5 - 978 1 78643 667 2
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Bokkapitel (refereegranskat)
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| 31. |
- Söderberg, Kristina, et al.
(författare)
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Kompetenspasset : Ett samverkansprojekt drivet av Arbetsförmedlingen, Myndigheten för yrkeshögskolan, RISE Research Institute of Sweden. Slutrapport 2024-06-30
- 2024
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet Kompetenspasset har sitt ursprung i de stora utmaningar som Sverige står inför när det gäller kompetensförsörjning på en snabbt föränderlig arbetsmarknad och det samverkansprogram som inleddes under den förra regeringsperioden. Behovet av att kunna dokumentera och erkänna både formellt, icke-formellt och informellt lärande har ökat, och EU-rådets rekommendation kring mikromeriter har varit en drivkraft för att ta fram och testa hur en gemensam svensk modell för mikromeriter skulle kunna se ut och utformas.Projektet har bedrivits som ett samverkansprojekt mellan RISE Research Institutes of Sweden, som har lett projektet; Arbetsförmedlingen, som har bidragit med arbetsmarknadsinsikter och praktisk testning av mikromeriter; och Myndigheten för yrkeshögskolan, som har arbetat med hur SeQF och mikromeriter kan komplettera varandra. Projektet har pågått mellan 2021-09-01 till och med 2024- 06-30.För att möjliggöra detta projekts genomförande har projektet beviljats ekonomiska medel av Vinnova – Sveriges innovationsmyndighet, tillsammans med medfinansiering från projektets partners.
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| 32. |
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| 33. |
- Welin, Martin, et al.
(författare)
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Structural studies of tri-functional human GART
- 2010
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 38:20, s. 7308-19
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Tidskriftsartikel (refereegranskat)abstract
- Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. Structures are compared with those of homologous enzymes from prokaryotes and analyzed in terms of the catalytic mechanism. We also report small angle X-ray scattering models for the full-length protein. These models are consistent with the enzyme forming a dimer through the middle domain. The protein has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments. This resilient seesaw shape may facilitate internal substrate/product transfer or forwarding to other enzymes in the pathway.
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