| 1. |
- Nyström, Birgitta, et al.
(författare)
-
Introduktion
- 2017. - 1:1
-
Ingår i: Modern affärsrätt : En antologi - En antologi. - 9789139020370 ; , s. 9-28
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 2. |
- Arvidsson, Niklas, et al.
(författare)
-
Avtalade ansvarsbegränsningar
- 2017
-
Ingår i: Modern affärsrätt : En antologi - En antologi. - 9789139020370 ; , s. 71-85
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 3. |
- Arvidsson, Niklas, et al.
(författare)
-
Funktionsbrist i småhusentreprenad
- 2017
-
Ingår i: Modern affärsrätt : En antologi - En antologi. - 9789139020370 ; , s. 251-267
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Arvidsson, Niklas, et al.
(författare)
-
Cirkulära möbelflöden : Hur nya affärsmodeller kan bidra till hållbar utveckling inom offentliga möbler
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sverige har en stark möbelindustri och en stolt tradition av att tillverka tidlösa och högkvalitativa möbler, ofta av naturmaterial. 2016 producerade Sverige möbler för 22,8 miljarder SEK, varav kontorsmöbler stod för nästan en fjärdedel1. Det saknas idag statistik över vad som händer med dessa möbler när de inte längre används, men det står klart att många av dem slängs i förtid när verksamheter flyttar eller när deras behov ändras. Samtidigt syns en tydlig utveckling mot att kunder mer och mer efterfrågar återbrukade eller renoverade möbler som en del i sitt hållbarhetsarbete. Denna utveckling var startpunkten för projektet ”Affärsmodell-innovation för cirkulära möbelflöden”. Affärsmodellinnovation för cirkulära möbelflöden är ett Vinnovafinansierat projekt som under åren 2015-2017 arbetat med att utveckla och testa koncept för cirkulära affärsmodeller för i första hand offentliga möbler. I projektet har tjugo aktörer från hela värdekedjan, från underleverantörer, möbelproducenter, återförsäljare och användare till forskare och branschorgan, samarbetat kring affärsutveckling, kundincitament, produktdesign, logistik, hållbarhets- och certifieringsfrågor. Den här skriften belyser hur nya affärsmodeller för mer cirkulära möbelflöden kan bidra till en mer hållbar utveckling och ger smakprov på slutsatser från projektet. Skriften riktar sig framför allt till producenter och återförsäljare av möbler för offentliga miljöer, men även kunder och inköpare tror vi kan ha stor nytta av skriften. Vi hoppas att den även kan fungera som inspiration för andra industrier och branscher som funderar på en övergång till mer cirkulära affärsekosystem.
|
|
| 9. |
|
|
| 10. |
- Avelin, Benny, 1984-, et al.
(författare)
-
Boundary estimates for solutions to operators of p-Laplace type with lower order terms
- 2011
-
Ingår i: Journal of Differential Equations. - : Elsevier BV. - 0022-0396 .- 1090-2732. ; 250:1, s. 264-291
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper we study the boundary behavior of solutions to equations of the form∇⋅A(x,∇u)+B(x,∇u)=0, in a domain Ω⊂Rn, assuming that Ω is a δ-Reifenberg flat domain for δ sufficiently small. The function A is assumed to be of p-Laplace character. Concerning B, we assume that |∇ηB(x,η)|⩽c|η|p−2, |B(x,η)|⩽c|η|p−1, for some constant c, and that B(x,η)=|η|p−1B(x,η/|η|), whenever x∈Rn, η∈Rn∖{0}. In particular, we generalize the results proved in J. Lewis et al. (2008) [12] concerning the equation ∇⋅A(x,∇u)=0, to equations including lower order terms.
|
|
| 11. |
- Avelin, Benny, et al.
(författare)
-
Optimal doubling, reifenberg flatness and operators of p-laplace type
- 2011
-
Ingår i: Nonlinear Analysis. - : Elsevier BV. - 0362-546X .- 1873-5215. ; 74:17, s. 5943-5955
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we consider equations of p-Laplace type of the form ∇⋅A(x,∇u)=0. Concerning A we assume, for p∈(1,∞) fixed, an appropriate ellipticity type condition, Hölder continuity in x and that A(x,η)=|η|p−1A(x,η/|η|) whenever x∈Rn and η∈Rn∖{0}. Let Ω⊂Rn be a bounded domain, let D be a compact subset of Ω. We say that is the A-capacitary function for D in Ω if on D, on ∂Ω in the sense of and in Ω∖D in the weak sense. We extend to Rn∖Ω by putting on Rn∖Ω. Then there exists a unique finite positive Borel measure on Rn, with support in ∂Ω, such that In this paper, we prove that if Ω is Reifenberg flat with vanishing constant, then for every τ, 0<τ≤1. In particular, we prove that is an asymptotically optimal doubling measure on ∂Ω.
|
|
| 12. |
|
|
| 13. |
- Barbosa, Edna J L, 1961, et al.
(författare)
-
Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association study.
- 2014
-
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 9:8
-
Tidskriftsartikel (refereegranskat)abstract
- Growth hormone deficiency (GHD) in adults is associated with decreased extracellular water volume (ECW). In response to GH replacement therapy (GHRT), ECW increases and blood pressure (BP) reduces or remains unchanged. Our primary aim was to study the association between polymorphisms in genes related to renal tubular function with ECW and BP before and 1 year after GHRT. The ECW measures using bioimpedance analysis (BIA) and bioimpedance spectroscopy (BIS) were validated against a reference method, the sodium bromide dilution method (Br(-)).
|
|
| 14. |
|
|
| 15. |
- Dahlén, Elsa M, et al.
(författare)
-
Sagittal Abdominal Diameter is a more Independent Measure compared with Waist Circumference to predict Arterial Stiffness in subjects with Type 2 Diabetes
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Aim: The aim of this study was to prospectively explore how laboratory and anthropometric risk factors predicted subclinical organ damage in 255 patients, with type 2 diabetes, after four years. Methods: Baseline investigations were performed in 2006 and were repeated at follow-up in 2010. Carotid intima-media thickness (IMT) was evaluated by ultrasonography and aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries at baseline and at follow-up in a cohort of subjects with type 2 diabetes aged 55-65 years old. Results: There were significant correlations between apolipoprotein B (apoB) (r= 0.144, p=0.03), C - reactive protein (CRP) (r=0.172, p=0.009) at baseline and IMT measured at follow-up. After adjustment for sex, age, treatment with statins and Hba1c, the associations remained statistically significant. HbA1c, total cholesterol or LDL-cholesterol did not correlate to IMT at follow-up. Baseline body mass index (BMI) (r=0.130, p=0.049), waist circumference (WC) (r=0.147, p=0.027) and sagittal Abdominal Diameter (SAD) (r=0.184, p=0.007) correlated to PWV at follow-up. Challenged with sex, SBP and HbA1c, the association between SAD, not WC nor BMI, and PWV remained statistically significant (p=0.036). In a stepwise linear regression, entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV. Conclusion: We conclude that apoB and CRP, but not LDL-cholesterol predicted subclinical atherosclerosis. Furthermore, SAD was more independent in predicting arterial stiffness over time, compared with WC, in middle-aged men and women with type 2 diabetes.
|
|
| 16. |
- Döttling, Martin, et al.
(författare)
-
Chapter 4: System Concept and Architecture
- 2009
-
Ingår i: Radio Technologies and Concepts for IMT-Advanced. - : John Wiley & Sons. - 9780470747636
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 17. |
- Engstrand Lilja, Helene, 1963-, et al.
(författare)
-
Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome
- 2015
-
Ingår i: Microbiome. - : Springer Science and Business Media LLC. - 2049-2618. ; 3
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The composition of the intestinal microbiota seems to be an important factor in determining the clinical outcome in children with short bowel syndrome (SBS). Alterations in the microbiota may result in serious complications such as small bowel bacterial overgrowth (SBBO) and intestinal mucosal inflammation that lead to prolonged parenteral nutrition (PN) dependency with subsequently increased risk of liver failure and sepsis. To date, there are no reported mappings of the intestinal microbiome in children with SBS. Here, we present the first report on the intestinal microbial community profile in children with SBS. Findings: The study includes children diagnosed with SBS in the neonatal period. Healthy siblings served as controls. Fecal samples were collected, and microbial profiles were analyzed by using 16S rRNA gene sequencing on the Illumina MiSeq platform. We observed a pronounced microbial dysbiosis in children with SBS on PN treatment with an increased and totally dominating relative abundance of Enterobacteriacae in four out of five children compared to children with SBS weaned from PN and healthy siblings. Conclusions: The overall decreased bacterial diversity in children with SBS is consistent with intestinal microbiome mappings in inflammatory bowel diseases such as Crohn's disease and necrotizing enterocolitis in preterm infants. Our findings indicate that intestinal dysbiosis in children with SBS is associated with prolonged PN dependency.
|
|
| 18. |
- Flodgren, Boel, et al.
(författare)
-
Affärsrätten i centrum
- 2017. - 1:1
-
Ingår i: Modern affärsrätt : En antologi - En antologi. - 9789139020370 ; , s. 29-50
-
Bokkapitel (refereegranskat)abstract
- Kapitlet innehåller en genomgång, framförallt utifrån ett förmögenhetsrättsligt perspektiv, av olika aktuella frågor inom den moderna affärsrätten. Utgångspunkten för kapitlet är att den nya ekonomin kräver nya spelregler men att affärsrätten också ska värna bestående rättsstatliga värden som rättvisa, förutsebarhet och rättssäkerhet. Det behandlar allmänna principer, etiken i affärsrätten och säger något kort om Law and Management. I kapitlet uppmärksammas olika behov av klarläggande av vad som gäller inom affärsrätten idag, och kapitlet blir därmed också en inventering av några aktuella forskningsfrågor inom modern affärsrätt.
|
|
| 19. |
|
|
| 20. |
- Fredriksson, Fanny, 1985-, et al.
(författare)
-
Improved Outcome of Intestinal Failure in Preterm Infants
- 2020
-
Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Wolters Kluwer. - 0277-2116 .- 1536-4801. ; 71:2, s. 223-231
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The aims were to evaluate the outcome and to identify predictors for survival and enteral autonomy in neonatal intestinal failure (IF).METHODS: A retrospective observational study in a Swedish tertiary centre of children born between 1995 and 2016 with neonatal IF, defined as dependency on parenteral nutrition (PN) ≥60 days, starting with PN before the age of 44 gestational weeks. Data were extracted from medical records and predictors for survival and enteral autonomy were identified by the Cox regression model. Time to death and weaning off PN analysis were performed with Kaplan-Meier curves including log rank test.RESULTS: In total, 105 children were included. Median gestational age was 28 weeks (22-42), 50% were born extremely preterm (<28 gestational weeks). PN started at a median age of two days (0-147) with a median duration of 196 days (60-3091). Necrotising enterocolitis was the dominating cause of IF (61%). Overall survival was 88%, five children died of sepsis and four of intestinal failure-associated liver disease. Survival increased from 75% during 1995-2008 to 96% during 2009-2016 (p = 0.0040). Age-adjusted small bowel length of >50% and birth 2009-2016 were predictors for survival. Enteral autonomy was achieved in 87%, with positive prediction by small bowel length of >25% of expected for gestational age and remaining ileocaecal valve.CONCLUSION: Preterm neonates with IF, at high risk of IF associated morbidity, showed a high overall survival rate. Small-bowel length and being born 2009-2016 were predictors for survival and remaining ICV and small-bowel length were predictors for enteral autonomy.
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
- Holmberg, Mats, 1958, et al.
(författare)
-
A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease
- 2022
-
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:4, s. 1040-1052
-
Tidskriftsartikel (refereegranskat)abstract
- Context: Neuropsychiatric symptoms are common features of Graves disease (GD) in hyperthyroidism and after treatment. The mechanism behind these symptoms is unknown, but reduced hippocampal volumes have been observed in association with increased thyroid hormone levels. Objective: This work aimed at investigating GD influence on regional medial temporal lobe (MTL) volumes. Methods: Sixty-two women with newly diagnosed GD underwent assessment including magnetic resonance (MR) imaging in hyperthyroidism and 48 of them were followed up after a mean of 16.4±4.2 SD months of treatment. Matched thyroid-healthy controls were also assessed twice at a 15-month interval. MR images were automatically segmented using multiatlas propagation with enhanced registration. Regional medial temporal lobe (MTL) volumes for amygdalae and hippocampi were compared with clinical data and data from symptom questionnaires and neuropsychological tests. Results: Patients had smaller MTL regions than controls at inclusion. At follow-up, all 4 MTL regions had increased volumes and only the volume of the left amygdala remained reduced compared to controls. There were significant correlations between the level of thyrotropin receptor antibodies (TRAb) and MTL volumes at inclusion and also between the longitudinal difference in the levels of free 3,5,3′-triiodothyronine and TRAb and the difference in MTL volumes. There were no significant correlations between symptoms or test scores and any of the 4 MTL volumes. Conclusion: Dynamic alterations in the amygdalae and hippocampi in GD reflect a previously unknown level of brain involvement both in the hyperthyroid state of the condition and after treatment. The clinical significance, as well as the mechanisms behind these novel findings, warrant further study of the neurological consequences of GD.
|
|
| 24. |
|
|
| 25. |
- Holmberg, Mats, 1958, et al.
(författare)
-
Structural brain changes in hyperthyroid Graves' disease: protocol for an ongoing longitudinal, case-controlled study in Göteborg, Sweden-the CogThy project.
- 2019
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 9:11
-
Tidskriftsartikel (refereegranskat)abstract
- Cognitive impairment and reduced well-being are common manifestations of Graves' disease (GD). These symptoms are not only prevalent during the active phase of the disease but also often prevail for a long time after hyperthyroidism is considered cured. The pathogenic mechanisms involved in these brain-derived symptoms are currently unknown. The overall aim of the CogThy study is to identify the mechanism behind cognitive impairment to be able to recognise GD patients at risk.The study is a longitudinal, single-centre, case-controlled study conducted in Göteborg, Sweden on premenopausal women with newly diagnosed GD. The subjects are examined: at referral, at inclusion and then every 3.25 months until 15 months. Examinations include: laboratory measurements; eye evaluation; neuropsychiatric and neuropsychological testing; structural MRI of the whole brain, orbits and medial temporal lobe structures; functional near-infrared spectroscopy of the cerebral prefrontal cortex and self-assessed quality of life questionnaires. The primary outcome measure is the change in medial temporal lobe structure volume. Secondary outcome measures include neuropsychological, neuropsychiatric, hormonal and autoantibody variables. The study opened for inclusion in September 2012 and close for inclusion in October 2019. It will provide novel information on the effect of GD on medial temporal lobe structures and cerebral cortex functionality as well as whether these changes are associated with cognitive and affective impairment, hormonal levels and/or autoantibody levels. It should lead to a broader understanding of the underlying pathogenesis and future treatment perspectives.The study has been reviewed and approved by the Regional Ethical Review Board in Göteborg, Sweden. The results will be actively disseminated through peer-reviewed journals, national and international conference presentations and among patient organisations after an appropriate embargo time.44321 at the public project database for research and development in Västra Götaland County, Sweden (https://www.researchweb.org/is/vgr/project/44321).
|
|
| 26. |
- Holmqvist, Niklas, et al.
(författare)
-
Lake trophic status and bioaccumulation of polychlorinated biphenyls in benthic organisms: a comparison between littoral and profundal invertebrates
- 2005
-
Ingår i: Canadian Journal of Fisheries and Aquatic Sciences. - 1205-7533. ; 62:6, s. 1201-1209
-
Tidskriftsartikel (refereegranskat)abstract
- We investigated the influence of lake trophic status on accumulation of polychlorinated biphenyls (PCBs) in littoral and profundal invertebrates from 19 lakes in southern Sweden. The PCB concentration in profundal chironomids (Chironomus sp.) was negatively correlated with lake trophy but the concentration in littoral crayfish (Pacifasticus leniusculus) was unrelated to shifting nutrient regimes. PCB concentrations in chironomids were negatively correlated, while crayfish did not correlate with lake total phosphorus. Two findings indicate that different processes determine bioaccumulation in littoral and profundal invertebrates: (i) a lack of correlation between PCB concentrations in crayfish and chironomids within lakes and (ii) some differences in congener distribution in the two species. We suggest a possible explanation in that chironomids are directly exposed to settling material from the pelagic zone, while crayfish are omnivorous and feed mainly in the littoral zone. A intensive investigation on one pond population could not reveal any individual factors, such as lipid content, size, or sex, influencing bioaccumulation of PCBs in crayfish.
|
|
| 27. |
- Holmqvist, Niklas, et al.
(författare)
-
Low levels of persistent organic pollutants (POPS) in New Zealand eels reflect isolation from atmospheric sources
- 2006
-
Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491. ; 141:3, s. 532-538
-
Tidskriftsartikel (refereegranskat)abstract
- Polychlorinated biphenyls (PCBs) and organic pesticides (i.e., DDTs) were measured in long finned eels (Anguilla dieffenbachii) in 17 streams on the west coast of South Island, New Zealand. Very low levels of PCBs and low levels of ppDDE were found. The concentrations of PCBs and ppDDE were not correlated within sites indicating that different processes determined the levels of the two pollutants in New Zealand eels. The PCBs probably originate from atmospheric transport, ppDDE levels are determined by land use and are higher in agriculture areas. The low contamination level of these aquatic systems seems to be a function of a low input from both long and short-range transport as well as few local point sources. No correlation could be found between lipid content and persistent organic pollutants (POPs) concentration (as shown in previous studies) in the eels which could be explained by low and irregular intake of the pollutants.
|
|
| 28. |
- Holmqvist, Niklas, et al.
(författare)
-
Persistent organic pollutants (POP) in a benthic omnivore - A comparison between lake and stream crayfish populations
- 2007
-
Ingår i: Chemosphere. - : Elsevier BV. - 1879-1298 .- 0045-6535. ; 66:6, s. 1070-1078
-
Tidskriftsartikel (refereegranskat)abstract
- We investigated the accumulation of PCB and DDT in crayfish populations in 10 streams in southern Sweden. The results were compared with an earlier study on crayfish in lakes from the same area. We found that the concentration of pollutants in crayfish did not differ between the two types of systems. Variation in body burden was higher in stream living crayfish probably because of the higher influence from pollutants deposited in the catchment area and the more dynamic transport in streams. In streams, pp'-DDE concentrations were positively correlated to trophic status (total phosphorous) while PCB did not show any correlation with the nutrient regime. Further, mean Sigma PCB and p,p'-DDE concentrations in crayfish did not correlate in streams. We suggest that the sources of the two pollutants differ for stream living crayfish. The results indicate that crayfish in streams are affected to a higher degree to pollutants in the catchment area and the precipitation regime. In lakes, internal processes govern uptake of pollutants in crayfish.
|
|
| 29. |
|
|
| 30. |
- Kassa, Ann-Marie, 1955-, et al.
(författare)
-
Experiences and satisfaction of video follow up of children with paediatric gastrointestinal conditions linking tertiary centre with guardians and clinicians at the local hospital : a cross-sectional study
- 2024
-
Ingår i: BMC Pediatrics. - : BioMed Central (BMC). - 1471-2431. ; 24:1
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundChildren with complicated gastrointestinal conditions are dependent on follow up by tertiary care specialists throughout childhood to prevent and treat complications. In Sweden, paediatric surgical- and intestinal rehabilitation centres are centralised which means that many patients and guardians have to travel long distances to access tertiary referral centres. Our tertiary referral centre has developed a model of shared care with video conferences for follow up with our centre and the patient and guardians attending together with the responsible professionals at the local hospital. This study aimed to investigate the experiences and satisfaction with video follow-up visits (VFV) between a tertiary referral centre and guardians and clinicians at their local hospital.MethodsEligible participants were families with children with oesophageal atresia, intestinal failure and intestinal motility disorders and their local clinicians attending VFV with our tertiary referral centre from 2015 to 2020. Questionnaires included fixed-response alternatives, a 6-point Likert scale and open questions.ResultsFifty-seven out of 102 families (56%) and 19 out of 27 local clinicians (70%) responded the questionnaires. In 68% of the VFV, two guardians attended compared to 35% in the physical visits. Of the guardians attending VFV, 82% lost ≤ half a working day and 91% attending physical visits lost ≥ one full working day. Median distance to the tertiary referral centre was 267 km and attending VFV avoided emissions of 7.2 metric tonnes of CO2. Of the guardians, 90% and of the clinicians 95% were satisfied with VFV. Advantages were avoidance of travelling and the participants shared the same information.ConclusionsVFV is an appropriate alternative to physical visits with a high grade of satisfaction among the guardians and clinicians. VFV was time-saving for the families and reduced CO2 emissions.
|
|
| 31. |
|
|
| 32. |
- Larsson, Per, et al.
(författare)
-
Heavy metals and stable isotopes in a benthic omnivore in a trophic gradient of lakes
- 2007
-
Ingår i: Environmental Science & Technology. - : American Chemical Society (ACS). - 1520-5851 .- 0013-936X. ; 41:17, s. 5973-5979
-
Tidskriftsartikel (refereegranskat)abstract
- Heavy metals (Cd, Hg, and Pb) and stable isotopes (N-15, C-13) in crayfish (Pacifastacus leniusculus) were studied in a trophic gradient of lakes (N = 19) in southern Sweden. Trophic indicators of the lakes as total phosphorus (tot-P) varied from 5 to 93 mu g/L. The examined lakes had no known point sources of heavy metals, but the catchment areas varied from mainly forested to agricultural land. Cd and Hg in crayfish were affected by the trophic status of the lakes, showing significant negative relationship with tot-P, total nitrogen, and chlorophyll A content and a positive relationship with lake transparency (Secchi depth). The concentration of these two heavy metals was thus higher in crayfish in the oligotrophic lakes and decreased linearly to the eutrophic ones. Pb was not related to any lake variable. Stable isotopes of carbon (delta C-13) and nitrogen (615N) in crayfish were a reflection of that found in the sediment as shown by positive linear relationships for the lakes. In the sediment of the lakes, delta C-13 signature showed significant negative relationships with the trophic indicators but positive results were shown for lake transparency. The trophic gradient of the lakes was reflected by delta C-13 in the sediment and in the crayfish. 615N in crayfish was a reflection of 615N in the sediment but the relationship was not coupled to the trophic statue of the lakes. The results from the study show that Cd and Hg in benthic omnivores as crayfish are affected by ecological processes in lakes, such as eutrophication. Stable isotopes, such as 13C and 15 N, can be used to study these ecological processes.
|
|
| 33. |
- Ledendal, Jonas, et al.
(författare)
-
Ideella organisationers medverkan i tvister på dataskyddsrättens område
- 2020
-
Ingår i: Tvistlösning inom affärsrätten. - 9789139022213 ; , s. 311-327
-
Bokkapitel (refereegranskat)abstract
- EU:s dataskyddsförordning innehåller bestämmelser om vissa ideella organisationers behörighet att uppträda som ombud för registrerade samt om sådan organisationers talerätt. Syftet med denna artikel är att undersöka vilka möjligheter sådana organisationer enligt gällande svensk rätt har att delta i övervakningen av dataskyddsreglernas efterlevnad.
|
|
| 34. |
- Lewis, John L., et al.
(författare)
-
Boundary Harnack inequalities for operators of p-Laplace type in Reifenberg flat domains
- 2008
-
Ingår i: Perspectives in Partial Differential Equations, Harmonic Analysis and Applications. - : American Mathematical Society (AMS). - 9780821844243 ; , s. 229-266
-
Bokkapitel (refereegranskat)abstract
- In this paper we highlight a set of techniques that recently have been used to establish boundary Harnack inequalities for p-harmonic functions vanishing on a portion of the boundary of a domain which is ‘flat’ in the sense that its boundary is well-approximated by hyperplanes. Moreover, we use these techniques to establish new results concerning boundary Harnack inequalities and the Martin boundary problem for operators of p-Laplace type with variable coefficients in Reifenberg flat domains.
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
- Lindström, Niklas, et al.
(författare)
-
An Analysis of Enterprise Architecture for Federated Environments
- 2017
-
Ingår i: The Practice of Enterprise Modeling. - Cham : Springer. - 9783319702407 - 9783319702414 ; , s. 156-170
-
Konferensbidrag (refereegranskat)abstract
- The challenge of business and IT-alignment has been a major concern for IT managers over the last few decades, as an increased congruence between the two aspects improves effectivity and results in organizations. Enterprise Architecture (EA) addresses the alignment by providing a holistic model-based view of the organization. However, previous research has revealed some generic discrepancies in prominent EA frameworks regarding their support towards more decentralized organizational structures. Following a case study research of a federated organization this paper analyzes in depth The Open Group Architecture Framework (TOGAF) EA framework, and based on identified discrepancies how it should be extended to provide an adequate support. By enabling the establishment and maintenance of a federated EA, the proposed extension should further increase the business and IT-alignment for federated organizations.
|
|
| 39. |
- Lundström, Niklas L.P. 1980-, et al.
(författare)
-
On a two-phase free boundary condition for p-harmonic measures
- 2009
-
Ingår i: Manuscripta mathematica. - : Springer. - 0025-2611 .- 1432-1785. ; 129:2, s. 231-249
-
Tidskriftsartikel (refereegranskat)abstract
- Let Ωi⊂Rn,i∈{1,2} , be two (δ, r 0)-Reifenberg flat domains, for some 0<δ<δ^ and r 0 > 0, assume Ω1∩Ω2=∅ and that, for some w∈Rn and some 0 < r, w∈∂Ω1∩∂Ω2,∂Ω1∩B(w,2r)=∂Ω2∩B(w,2r) . Let p, 1 < p < ∞, be given and let u i , i∈{1,2} , denote a non-negative p-harmonic function in Ω i , assume that u i , i∈{1,2}, is continuous in Ω¯i∩B(w,2r) and that u i = 0 on ∂Ωi∩B(w,2r) . Extend u i to B(w, 2r) by defining ui≡0 on B(w,2r)∖Ωi. Then there exists a unique finite positive Borel measure μ i , i∈{1,2} , on R n , with support in ∂Ωi∩B(w,2r) , such that if ϕ∈C∞0(B(w,2r)) , then∫Rn|∇ui|p−2⟨∇ui,∇ϕ⟩dx=−∫Rnϕdμi.Let Δ(w,2r)=∂Ω1∩B(w,2r)=∂Ω2∩B(w,2r) . The main result proved in this paper is the following. Assume that μ 2 is absolutely continuous with respect to μ 1 on Δ(w, 2r), d μ 2 = kd μ 1 for μ 1-almost every point in Δ(w, 2r) and that logk∈VMO(Δ(w,r),μ1) . Then there exists δ~=δ~(p,n)>0 , δ~<δ^ , such that if δ≤δ~ , then Δ(w, r/2) is Reifenberg flat with vanishing constant. Moreover, the special case p = 2, i.e., the linear case and the corresponding problem for harmonic measures, has previously been studied in Kenig and Toro (J Reine Angew Math 596:1–44, 2006).
|
|
| 40. |
|
|
| 41. |
- Lundström, Niklas L P, et al.
(författare)
-
Systems of variational inequalities in the context of optimal switching problems and operators of Kolmogorov type
- 2014
-
Ingår i: Annali di Matematica Pura ed Applicata. - : Springer. - 0373-3114 .- 1618-1891. ; 193:4, s. 1213-1247
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper we study the system where . A special case of this type of system of variational inequalities with terminal data occurs in the context of optimal switching problems. We establish a general comparison principle for viscosity sub- and supersolutions to the system under mild regularity, growth, and structural assumptions on the data, i.e., on the operator and on continuous functions , , and . A key aspect is that we make no sign assumption on the switching costs and that is allowed to depend on as well as . Using the comparison principle, the existence of a unique viscosity solution to the system is constructed as the limit of an increasing sequence of solutions to associated obstacle problems. Having settled the existence and uniqueness, we subsequently focus on regularity of beyond continuity. In this context, in particular, we assume that belongs to a class of second-order differential operators of Kolmogorov type of the form: where . The matrix is assumed to be symmetric and uniformly positive definite in . In particular, uniform ellipticity is only assumed in the first coordinate directions, and hence, may be degenerate.
|
|
| 42. |
- Lundström, Niklas L.P., et al.
(författare)
-
The Boundary Harnack Inequality for Solutions to Equations of Aronsson type in the Plane
- 2011
-
Ingår i: Annales Academiae Scientiarum Fennicae Mathematica. - : Academia Scientiarum Fennica. - 1239-629X .- 1798-2383. ; 36, s. 261-278
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper we prove a boundary Harnack inequality for positive functions which vanish continuously on a portion of the boundary of a bounded domain \Omega \subset R2 and which are solutions to a general equation of p-Laplace type, 1 < p < \infty. We also establish the same type of result for solutions to the Aronsson type equation \nabla (F(x,\nabla u)) \cdot F\eta(x,\nabla u) = 0. Concerning \Omega we only assume that \partial\Omega is a quasicircle. In particular, our results generalize the boundary Harnack inequalities in [BL] and [LN2] to operators with variable coefficients.
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
- McArdle, Conor, et al.
(författare)
-
Simulation of a distributed CORBA-based SCP
- 2000
-
Ingår i: Telecommunications and IT convergence : towards service evolution : proceedings (Lecture notes in computer science). - 0302-9743 .- 1611-3349. - 3540671528 ; 1774, s. 33-48
-
Konferensbidrag (refereegranskat)abstract
- This paper examines load balancing issues relating to a distributed CORBA-based Service Control Point. Two types of load balancing strategies are explored through simulation studies: (i) a novel ant-based load balancing algorithm, which has been devised specically for this type of system. This algorithm is compared to more traditional algorithms, (ii) a method for optimal distribution of the computational objects composing the service programs. This is based on mathematically minimising the expected communication ows between network nodes and message-level processing costs. The simulation model has been based on the recently adopted OMG IN/CORBA Interworking specication and the TINA Service Session computational object model.
|
|
| 46. |
-
Modern affärsrätt : En antologi
- 2017. - 1:1
-
Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- I denna bok presenteras sexton uppsatser som belyser centrala och aktuella affärsrättsliga frågor. Efter ett fylligt introduktionskapitel följer uppsatser som bl.a. behandlar frågor kring handel och uthyrning över internet, delningsplattformar, avtalsfrihet, entreprenad, ansvarsbegränsningar, konsumenttjänster, marknadsföring, kommersiella truster, övergång av verksamheter, processuella överenskommelser, vindikation och separation.Författarna är alla forskare och lärare vid den handelsrättsliga och den juridiska institutionen vid Lunds universitet.Boken avser att vara av betydelse för det praktiska rättslivet men också att ge bidrag till den vetenskapliga diskussionen och undervisningen på affärsrättens område.
|
|
| 47. |
|
|
| 48. |
- Nyström, Niklas, et al.
(författare)
-
Human Enterovirus Species B in Ileocecal Crohn's Disease
- 2013
-
Ingår i: Clinical and Translational Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 2155-384X. ; 4:6
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Advanced ileocecal Crohn's disease (ICD) is characterized by strictures, inflammation in the enteric nervous system (myenteric plexitis), and a high frequency ofNOD2mutations. Recent findings implicate a role ofNOD2and another CD susceptibility gene,ATG16L1, in the host response against single-stranded RNA (ssRNA) viruses. However, the role of viruses in CD is unknown. We hypothesized that human enterovirus species B (HEV-B), which are ssRNA viruses with dual tropism both for the intestinal epithelium and the nervous system, could play a role in ICD.METHODS:We used immunohistochemistry andin situhybridization to study the general presence of HEV-B and the presence of the two HEV-B subspecies, Coxsackie B virus (CBV) and Echovirus, in ileocecal resections from 9 children with advanced, stricturing ICD and 6 patients with volvulus, and in intestinal biopsies from 15 CD patients at the time of diagnosis.RESULTS:All patients with ICD had disease-associated polymorphisms inNOD2orATG16L1. Positive staining for HEV-B was detected both in the mucosa and in myenteric nerve ganglia in all ICD patients, but in none of the volvulus patients. Expression of the cellular receptor for CBV, CAR, was detected in nerve cell ganglia.CONCLUSIONS:The common presence of HEV-B in the mucosa and enteric nervous system of ICD patients in this small cohort is a novel finding that warrants further investigation to analyze whether HEV-B has a role in disease onset or progress. The presence of CAR in myenteric nerve cell ganglia provides a possible route of entry for CBV into the enteric nervous system.
|
|
| 49. |
- Nyström, Niklas
(författare)
-
Metabolomic features and viral infections in paediatric inflammatory bowel disease
- 2024
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Up to 25% of patients with inflammatory bowel disease have a paediatric onset (PIBD). The pathophysiological processes underlying PIBD are complex and largely unknown. Aims: To investigate a hypothesized role for human enterovirus B (HEV-B) in Crohn’s disease (CD) (I). To map and compare the mucosal and plasma metabolomes in new-onset PIBD patients and controls (II). To search for a new blood-based diagnostic biomarker for PIBD (III). To investigate the effect of exclusive enteral nutrition (EEN) treatment on the mucosal and plasma metabolomes in CD patients (IV). Methods: Immunohistochemistry and chromogen in situ hybridisation were used to search for HEV-B in surgical specimens from patients who had undergone surgery for stricturing ileocecal CD, and from volvulus patients as controls. Ultra-high-performance liquid chromatography mass spectrometry were used on biopsies and plasma from patients in the Uppsala PIBD inception cohort for metabolomic (II and IV) and lipidomic analyses (III). Patients were stratified by phenotypic subtypes and treatment responses. Symptomatic patients without PIBD were used as non-IBD controls. In Study III, two other independent PIBD inception cohorts were used for validation and confirmation. Results: I: HEV-B was detected in epithelial cells and neuronal ganglia of the enteric nervous system, and the specific cellular Coxsackie and adenovirus receptor (CAR) was expressed in both the intestinal epithelium and the enteric nervous system. II: Alterations in two metabolic compound classes were seen: decreased levels of lysophospholipids in inflamed ileum of CD patients and altered levels of sphingolipids in inflamed ileum and colon in both CD and ulcerative colitis, as compared with non-IBD controls. III: Discovery, validation and confirmation in three independent PIBD inception cohorts of a blood-based diagnostic two-lipid signature of PIBD. IV: A generalised downregulation of the non-inflamed ileal lipid metabolism after successful remission induction with EEN, as compared with baseline, and also as compared with non-IBD controls. Reduction of several lysophospholipids was a characteristic feature of the post-EEN ileal metabolome.Conclusions: The demonstrated presence of HEV-B supports, but does not confirm, its hypothesised role in CD. The CD-associated downregulation of mucosal metabolism both at disease onset and after successful EEN-induced inflammation resolution indicates a central role for the ileal mucosal lipid metabolism in CD, including lysophospholipids. The blood-based two-lipid signature has the potential of becoming a diagnostic tool in the clinical work-up of suspected PIBD.
|
|
| 50. |
- Nyström, Niklas, et al.
(författare)
-
Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease : Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
- 2023
-
Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 17:3, s. 418-432
-
Tidskriftsartikel (refereegranskat)abstract
- Background and AimsTo advance the understanding of inflammatory bowel disease [IBD] pathophysiology, we compared the mucosal and plasma metabolomes between new-onset paediatric IBD patients and symptomatic non-IBD controls, and correlated plasma inflammation markers and disease characteristics with the altered metabolites.MethodsPaired colonic and ileal biopsies and plasma from 67 treatment-naïve children with incident Crohn’s disease [CD; n = 47], ulcerative colitis [UC; n = 9], and non-IBD controls [n = 11] were analysed using ultra-performance liquid chromatography-mass spectrometry [UPLC-MS/MS]. Inflammatory plasma proteins [n = 92] were assessed.ResultsThe metabolomes in inflamed mucosal biopsies differed between IBD patients and controls. In CD, mucosal levels of several lysophospholipids [lysophosphatidylcholines, lysophosphatidyletanolamines, lysophosphatidylinositols, and lysophosphatidylserines] were decreased, correlating with various plasma metabolites including amino acid analogues and N-acetylated compounds. In both CD and UC, mucosal sphingolipids, including ceramide [d18:2/24:1, d18:1/24:2], lactosyl-N-palmitoyl-sphingosine [d18:1/16:0], behenoyl sphingomyelin [d18:1/22:0], lignoceroyl sphingomyelin [d18:1/24:0], and/or sphingomyelin [d18:1/24:1, d18:2/24:0] were increased, correlating with sphingolipids, bile acids, and/or N-acetylated metabolites in plasma. Among proteins associated with CD, interleukin-24 correlated with plasma metabolites, including lactosyl-N-palmitoyl sphingosine [d18:1/16:0] and phosphatidyletanolamine [18:1/18:1], haemoglobin, and faecal calprotectin. In UC, interleukin-24, interleukin-17A, and C-C motif chemokine 11 correlated with several plasma metabolites, including N-acetyltryptophan, tryptophan, glycerate, and threonate, and with the Paediatric Ulcerative Colitis Activity Index, C-reactive protein, and faecal calprotectin.ConclusionsMucosal perturbations of lysophospholipids and sphingolipids characterised the metabolome in new-onset paediatric IBD and correlated with plasma metabolites. By integrating plasma metabolomics data with inflammatory proteins and clinical data, we identified clinical and inflammatory markers associated with metabolomic signatures for IBD.
|
|
