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Sökning: WFRF:(O'Brien Russel)

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1.
  • Mittler, Eva, et al. (författare)
  • Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody
  • 2023
  • Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 15:700
  • Tidskriftsartikel (refereegranskat)abstract
    • Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.
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  • Omland, Torbjørn, et al. (författare)
  • N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes.
  • 2002
  • Ingår i: Circulation. - 1524-4539. ; 106:23, s. 2913-8
  • Tidskriftsartikel (refereegranskat)abstract
    • B-type natriuretic peptide (BNP) is a predictor of short- and medium-term prognosis across the spectrum of acute coronary syndromes (ACS). The N-terminal fragment of the BNP prohormone, N-BNP, may be an even stronger prognostic marker. We assessed the relation between subacute plasma N-BNP levels and long-term, all-cause mortality in a large, contemporary cohort of patients with ACS.
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