| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Elks, Cathy E, et al.
(författare)
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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1077-85
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Tidskriftsartikel (refereegranskat)abstract
- To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
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| 3. |
- Zuntini, Alexandre R., et al.
(författare)
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Phylogenomics and the rise of the angiosperms
- 2024
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Ingår i: NATURE. - 0028-0836 .- 1476-4687. ; 629, s. 843-850
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Tidskriftsartikel (refereegranskat)abstract
- Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods(1,2). A robust understanding of angiosperm evolution is required to explain their rise to ecological dominance. So far, the angiosperm tree of life has been determined primarily by means of analyses of the plastid genome(3,4). Many studies have drawn on this foundational work, such as classification and first insights into angiosperm diversification since their Mesozoic origins(5-7). However, the limited and biased sampling of both taxa and genomes undermines confidence in the tree and its implications. Here, we build the tree of life for almost 8,000 (about 60%) angiosperm genera using a standardized set of 353 nuclear genes(8). This 15-fold increase in genus-level sampling relative to comparable nuclear studies(9) provides a critical test of earlier results and brings notable change to key groups, especially in rosids, while substantiating many previously predicted relationships. Scaling this tree to time using 200 fossils, we discovered that early angiosperm evolution was characterized by high gene tree conflict and explosive diversification, giving rise to more than 80% of extant angiosperm orders. Steady diversification ensued through the remaining Mesozoic Era until rates resurged in the Cenozoic Era, concurrent with decreasing global temperatures and tightly linked with gene tree conflict. Taken together, our extensive sampling combined with advanced phylogenomic methods shows the deep history and full complexity in the evolution of a megadiverse clade.
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| 4. |
- Watts, Eleanor L., et al.
(författare)
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Observational and genetic associations between cardiorespiratory fitness and cancer : a UK Biobank and international consortia study
- 2024
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Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 130, s. 114-124
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association of fitness with cancer risk is not clear.Methods: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.Results: After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated.Discussion: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.
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| 5. |
- Zhou, Zheng, et al.
(författare)
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Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens : a CIBMTR report
- 2020
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 4:13, s. 3180-3190
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Tidskriftsartikel (refereegranskat)abstract
- There is a lack of large comparative study on the outcomes of reduced intensity conditioning (RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and fludarabine/melphalan (FM) regimens. Adult AML patients from Center for International Blood and Marrow Transplant Research who received first RIC allo-transplant between 2001 and 2015 were studied. Patients were excluded if they received cord blood or identical twin transplant, total body irradiation in conditioning, or graft-versus-host disease (GVHD) prophylaxis with in vitro T-cell depletion. Primary outcome was overall survival (OS), secondary end points were leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and GVHD. Multivariate survival model was used with adjustment for patient, leukemia, and transplant-related factors. A total of 622 patients received FM and 791 received FB RIC. Compared with FB, the FM group had fewer transplant in complete remission (CR), fewer matched sibling donors, and less usage of anti-thymocyte globulin or alemtuzumab. More patients in the FM group received marrow grafts and had transplantation before 2005. OS was significantly lower within the first 3 months posttransplant in the FM group (hazard ratio [HR] = 1.82, P < .001), but was marginally superior beyond 3 months (HR = 0.87, P = .05). LFS was better with FM compared with FB (HR = 0.89, P = .05). NRM was significantly increased in the FM group during the first 3 months of posttransplant (HR = 3.85, P < .001). Long-term relapse was lower with FM (HR = 0.65, P < .001). Analysis restricted to patients with CR showed comparable results. In conclusion, compared with FB, the FM RIC showed a marginally superior long-term OS and LFS and a lower relapse rate. A lower OS early posttransplant within 3 months was largely the result of a higher early NRM.
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| 6. |
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| 7. |
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| 8. |
- Isgren, Ellinor, et al.
(författare)
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Science has much to offer social movements in the face of planetary emergencies
- 2019
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Ingår i: Nature Ecology and Evolution. - : Springer Science and Business Media LLC. - 2397-334X. ; 3:11, s. 1498-1498
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Tidskriftsartikel (refereegranskat)abstract
- To the Editor — Ecologists Gardner and Wordley1 recently argued that in the face of “interconnected planetary emergencies threatening our climate and ecosystems,” information on the severity and urgency of the problem is insufficient to promote the necessary social and political change. Thus, “scientists should join civil disobedience movements to fight these unprecedented crises”. That the realization that facts alone may be insufficient is only now making headlines in the context of climate change is not the fault of the authors, but rather symptomatic of a long-standing disconnect between the natural and social sciences. While we support their ambitions, we argue that Gardner and Wordley neglect one of the most important, powerful and unique avenues for scientists to contribute to social movements — that is, with our arduously accumulated knowledge about processes of social and political change
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| 9. |
- Nelson, Laura, et al.
(författare)
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FKBPL: a marker of good prognosis in breast cancer.
- 2015
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:14, s. 12209-12223
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Tidskriftsartikel (refereegranskat)abstract
- FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemistry (IHC). In a meta-analysis, FKBPL levels were a significant predictor of BCSS; low FKBPL levels indicated poorer breast cancer specific survival (BCSS) (hazard ratio (HR) = 1.30, 95% confidence interval (CI) 1.14-1.49, p < 0.001). The prognostic impact of FKBPL remained significant after adjusting for other known prognostic factors (HR = 1.25, 95% CI 1.07-1.45, p = 0.004). For the sub-groups of 2365 estrogen receptor (ER) positive patients and 1649 tamoxifen treated patients, FKBPL was significantly associated with BCSS (HR = 1.34, 95% CI 1.13-1.58, p < 0.001, and HR = 1.25, 95% CI 1.04-1.49, p = 0.02, respectively). A univariate analysis revealed that FKBPL was also a significant predictor of relapse free interval (RFI) within the ER positive patient group, but it was only borderline significant within the smaller tamoxifen treated patient group (HR = 1.32 95% CI 1.05-1.65, p = 0.02 and HR = 1.23 95% CI 0.99-1.54, p = 0.06, respectively). The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic.
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| 10. |
- Olsson, Lennart, et al.
(författare)
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A Social Science Perspective on Resilience
- 2016
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Ingår i: The Routledge Handbook of International Resilience. - 9781138784321 - 9781315765006 ; , s. 49-62
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Bokkapitel (refereegranskat)
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| 11. |
- Almedom, Astier, et al.
(författare)
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Principles of epistemological accountability with methodological implications for measuring, assessing, and profiling human resilience
- 2015
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Ingår i: Ecology & Society. - 1708-3087. ; 20:3, s. 9-9
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Tidskriftsartikel (refereegranskat)abstract
- We propose two fundamental principles of epistemological accountability with critical methodological implications for studies designed to measure, assess, and/or profile human psychosocial resilience. Firstly, researchers involved in human psychosocial resilience studies owe it to the individuals and communities that they engage to disclose their motives and possible misreadings of the situations they enter, albeit with good intentions. Secondly, researchers and those individuals researched need to share a language of colearning and coproduction, and utilization of knowledge that is mutually intelligible. Again, the onus is on researchers and their funders to respect the researched and their particular epistemological sovereignties. As the number of published examples of authentic community-and/or needs-driven research and action to strengthen human psychosocial resilience increases, the sustainability of human social well-being and harmony may also be expected to rise. Psychosocial resilience encompasses a dynamic multidimensional set of personal capabilities as well as social and material assets/resources that individuals, families, and communities mobilize to mentally and emotionally embrace "turbulent" change and transformation while maintaining routine functioning without loss of identity, integrity, or core purpose in life that defines them as who they are individually as well as collectively. These proposed informed predictions are yet to be widely adopted and applied in the new paradigm for advancing this century of human psychosocial resilience, well-being, and sustainability.
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| 12. |
- Hansen, Melissa, et al.
(författare)
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The Best Laid Plans: Using the Capability Approach to Assess Neoliberal Conservation in South Africa-The Case of the iSimangaliso Wetland Park
- 2015
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Ingår i: The Journal of Environment & Development. - : SAGE Publications. - 1552-5465 .- 1070-4965. ; 24:4, s. 395-417
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Tidskriftsartikel (refereegranskat)abstract
- The article documents the case of South Africa's struggle to reconcile racially based poverty, a legacy of apartheid, and attempts to conserve the country's unique and important biodiversity. We present an analysis of KwaDapha, a small village in the iSimangaliso Wetland Park in northern KwaZulu-Natal, a protected area and UNESCO World Heritage Site, in terms of the capability approach. Despite South Africa's strong human rights orientation, we show that the freedom, or agency, of local users and inhabitants to achieve doings and beings according to their own values and norms, is constrained by state-led conservation management at KwaDapha. We suggest that the intellectual cause of this failure might lie in the conflation of two distinct concepts: human rights and the capability approach, in the iSimangaliso Wetland Park's predominantly market-based operationalization of sustainable development.
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| 13. |
- Isgren, Ellinor, et al.
(författare)
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Pluralism in Search of Sustainability: Ethics, Knowledge and Methdology in Sustainability Science
- 2017
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Ingår i: Challenges in Sustainability. - : Librello. - 2297-6477. ; 5:1, s. 2-6
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Tidskriftsartikel (refereegranskat)abstract
- Sustainability Science is an emerging, transdisciplinary academic field that aims to help build a sustainable global society by drawing on and integrating research from the humanities and the social, natural, medical and engineering sciences. Academic knowledge is combined with that from relevant actors from outside academia, such as policy-makers, businesses, social organizations and citizens. The field is focused on examining the interactions between human, environmental, and engineered systems to understand and contribute to solutions for complex challenges that threaten the future of humanity and the integrity of the life support systems of the planet, such as climate change, biodiversity loss, pollution, and land and water degradation. Since its inception in around the year 2000, and as expressed by a range of proponents in the field, sustainability science has become an established international platform for interdisciplinary research on complex social problems [1]. This has been done by exploring ways to promote ‘greater integration and cooperation in fulfilling the sustainability science mandate’ [2]. Sustainability science has thereby become an extremely diverse academic field, yet one with an explicit normative mission. After nearly two decades of sustainability research, it is important to reflect on a major question: what critical knowledge can we gain from sustainability science research on persistent socio-ecological problems and new sustainability challenges?
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| 14. |
- Kahn, Justine M., et al.
(författare)
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Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases
- 2020
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Ingår i: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:9, s. 2084-2094
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Tidskriftsartikel (refereegranskat)abstract
- We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). Weincluded 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Median follow-up of survivors was 7.8 years. Diagnoses included severe aplastic anemia (SAA; 24%), Fanconi anemia (FA; 10%), other marrow failure (6%), hemoglobinopathy (15%), immunodeficiency (23%), and metabolic/leukodystrophy syndrome (22%). Ten-year survival was 93% (95% confidence interval [95% CI], 92% to 94%; SMR, 4.2; 95% CI, 3.7-4.8). Seventy-one patients developed SNs (1.2%). Incidence was highest in FA (5.5%), SAA (1.1%), and other marrow failure syndromes (1.7%); for other NMDs, incidence was <1%. Hematologic (27%), oropharyngeal (25%), and skin cancers (13%) were most common. Leukemia risk was highest in the first 5 years posttransplantation; oropharyngeal, skin, liver, and thyroid tumors primarily occurred after 5 years. Despite a low number of SNs, patients had an 11-fold increased SN risk (SIR, 11; 95% CI, 8.9-13.9) compared with the general population. We report excellent long-term survival and low SN incidence in an international cohort of children undergoing HCT for NMDs. The risk of SN development was highest in patients with FA and marrow failure syndromes, highlighting the need for long-term posttransplantation surveillance in this population.
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| 15. |
- Metheny, Leland, et al.
(författare)
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Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults
- 2021
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Ingår i: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 27:11, s. 923.e1-923.e12
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Tidskriftsartikel (refereegranskat)abstract
- Patients who develop therapy-related myeloid neoplasm, either myelodysplastic syndrome (t-MDS) or acute myelogenous leukemia (t-AML), have a poor prognosis. An earlier Center for International Blood and Marrow Transplant Research (CIBMTR) analysis of 868 allogeneic hematopoietic cell transplantations (allo-HCTs) performed between 1990 and 2004 showed a 5-year overall survival (OS) and disease-free survival (DFS) of 22% and 21%, respectively. Modern supportive care, graft-versus-host disease prophylaxis, and reduced-intensity conditioning (RIC) regimens have led to improved outcomes. Therefore, the CIBMTR analyzed 1531 allo-HCTs performed in adults with t-MDS (n = 759) or t-AML (n = 772) between and 2000 and 2014. The median age was 59 years (range, 18 to 74 years) for the patients with t-MDS and 52 years (range, 18 to 77 years) for those with tAML. Twenty-four percent of patients with t-MDS and 11% of those with t-AML had undergone a previous autologous (auto-) HCT. A myeloablative conditioning (MAC) regimen was used in 49% of patients with t-MDS and 61% of patients with t-AML. Nonrelapse mortality at 5 years was 34% (95% confidence interval [CI], 30% to 37%) for patients with t-MDS and 34% (95% CI, 30% to 37%) for those with t-AML. Relapse rates at 5 years in the 2 groups were 46% (95% CI, 43% to 50%) and 43% (95% CI, 40% to 47%). Five-year OS and DFS were 27% (95% CI, 23% to 31%) and 19% (95% CI, 16% to 23%), respectively, for patients with t-MDS and 25% (95% CI, 22% to 28%) and 23% (95% CI, 20% to 26%), respectively, for those with t-AML. In multivariate analysis, OS and DFS were significantly better in young patients with low-risk t-MDS and those with t-AML undergoing HCT with MAC while in first complete remission, but worse for those with previous auto-HCT, higher-risk cytogenetics or Revised International Prognostic Scoring System score, and a partially matched unrelated donor. Relapse remains the major cause of treatment failure, with little improvement seen over the past 2 decades. These data mandate caution when recommending allo-HCT in these conditions and indicate the need for more effective antineoplastic approaches before and after allo-HCT.
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| 16. |
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| 17. |
- O Byrne, David
(författare)
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No more water, but fire next time : The conflict between environmental aims and social claims in Louisiana's post-Katrina coastal planning
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There are two levels to this thesis, the examination of the particular case and the exposition of the general approach. The case the thesis deals with is Louisiana’s coastal land-loss crisis and what can and should be done about it. I examine the current approach to coastal protection and restoration in the state of Louisiana, drawing on different economic theories of sustainable development and coastal geomorphology. Though the current plan is an improvement on previous efforts, it is still lacking in some areas. Amongst other problems, it is likely to put some fishers out of work, force them to relocate, and otherwise damage coastal communities. I argue that this is due to the critical capital approach to sustainable development that it employs which is based in utilitarian economic decisionmaking. Through a careful study of the present plan and by spotting its tensions and weaknesses, I propose an alternative approach to coastal planning which focuses on the expansion of capabilities. For this I draw on the work of Amartya Sen. I argue that this would address many problems with the current plan including those faced by the fishers. But examining the political and economic context, I find it is unlikely that the State will promote such an alternative, so I instead focus on an emergent fishers’ social movement as a potential agent of change, which can put pressure on the State to change its approach. Drawing on Gramsci’s theory of hegemony and social movement theory, in the political process tradition of Charles Tilly, I then translate this analysis into advice that might assist the movement in its struggle with the State.This thesis is also an example of a novel approach in sustainability research, which aims to make contributions at a number of levels. I propose that it provides an example of how to do interdisciplinary environmental research using the method of immanent critique; bringing together coastal geomorphology, political economy, and social movement theory. It brings together critical and problem-solving modes of research in a concrete case drawing on extended case work. I also propose a framework through which sustainability research can contribute to the practice of social movements as agent of social change towards sustainability.
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| 18. |
- O Byrne, David, et al.
(författare)
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Points of contestation in the biofuels debate: Perspectives from selected international organizations in the post 2007/08 food price crises
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The 2007/08 food price crisis brought unprecedented international attention to the relationship between food and biofuels, and their competition over land. In this article we sought to understand how the international policy framing of the nexus of food, fuel and land has developed since the food price crisis. We undertook an analysis of major reports, since the crisis, by three international policy prescriptive organizations representing food security, energy security and climate change concerns: the FAO, IEA and UNEP respectively. We analysed the contents of these reports under three categories: the policy/normative outlook, policy measures, instruments and technology, and scenarios and predictions. We found that while the IEA has remained optimistic about the potential of biofuels to contribute to both climate change mitigation and energy security, relying particularly on second generation fuels supported by government subsidies to reduce competition with food for land resources, both the FAO and UNEP appear to be growing increasingly skeptical particularly in relation to rural development. Both the FAO and UNEP show concern growing over the period since the crisis, firstly that second generation fuels with not deliver on the promise of reduced competition and secondly that biofuels production is causing problems related to local land rights in the global south. Scenarios predicting biofuel market share showed increases shortly after the crisis but have levelled off. Scenarios predicting future land use change due to biofuels firstly became less precise and later this parameter was no longer modelled. We discuss what implications the divergent and uncertain discourse around biofuels from these organizations has for the future of biofuels as a sustainable alternative to fossil fuels at the international level.
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| 19. |
- O Byrne, David, et al.
(författare)
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Teaching and learning sustainability: An assessment of the curriculum content and structure of sustainability degree programs in higher education
- 2015
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Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4057 .- 1862-4065. ; 10:1, s. 43-59
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Tidskriftsartikel (refereegranskat)abstract
- Sustainability degree programs in higher education have proliferated with the emergence of sustainability as a recognized academic field. This study evaluated the curricula of English-language programs granting degrees in sustainability by analyzing 27 bachelor's and 27 master's sustainability programs based on their (1) curricular structure, in terms of the proportion of core versus elective courses, (2) breadth of the core courses, which were classified into one of ten disciplinary categories, and (3) specific disciplinary content of core course subjects. We found that core courses made up the majority of both curricula, although bachelor's programs were more flexible than master's. Within these core courses, sustainability and social sciences were found in more than 85 % of both bachelor's and master's programs, as were natural sciences at the bachelor's level. Less than half of sustainability master's programs required a natural science course, which on average made up just 2 % of required course credits. No text was widely used in core sustainability courses. Our findings demonstrate that there is a wide divergence between the content of programs granting degrees in sustainability; many do not appear to be achieving the integration of natural and social sciences proposed in the literature. We believe that some shared foundations between programs is necessary for sustainability to develop into a mature scientific program that is recognizable across universities and understood by academics, employers, and civil society, and is effective in training the next generation of sustainability scholars and scientists.
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| 20. |
- Olsson, Lennart, et al.
(författare)
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Why resilience is unappealing to social science : Theoretical and empirical investigations of the scientific use of resilience
- 2015
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Resilience is often promoted as a boundary concept to integrate the social and natural dimensions of sustainability. However, it is a troubled dialogue from which social scientists may feel detached. To explain this, we first scrutinize the meanings, attributes, and uses of resilience in ecology and elsewhere to construct a typology of definitions. Second, we analyze core concepts and principles in resilience theory that cause disciplinary tensions between the social and natural sciences (system ontology, system boundary, equilibria and thresholds, feedback mechanisms, self-organization, and function). Third, we provide empirical evidence of the asymmetry in the use of resilience theory in ecology and environmental sciences compared to five relevant social science disciplines. Fourth, we contrast the unification ambition in resilience theory with methodological pluralism. Throughout, we develop the argument that incommensurability and unification constrain the interdisciplinary dialogue, whereas pluralism drawing on core social scientific concepts would better facilitate integrated sustainability research.
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| 21. |
- Percival, Mary-Elizabeth, et al.
(författare)
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Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation
- 2021
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Ingår i: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 56:9, s. 2108-2117
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Tidskriftsartikel (refereegranskat)abstract
- Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. We identified 2492 adult patients (1799 CR and 693 CRi) who underwent alloHCT between January 1, 2007 and December 31, 2015. The primary outcome was overall survival (OS). Multivariable analysis was performed to adjust for patient-, disease-, and transplant-related factors. Baseline characteristics were similar. Patients in CRi compared to those in CR had an increased likelihood of death (HR: 1.27; 95% confidence interval: 1.13-1.43). Compared to CR, CRi was significantly associated with increased non-relapse mortality (NRM), shorter disease-free survival (DFS), and a trend toward increased relapse. Detectable MRD was associated with shorter OS, shorter DFS, higher NRM, and increased relapse compared to absence of MRD. The deleterious effects of CRi and MRD were independent. In this large CIBMTR cohort, survival outcomes differ among AML patients based on depth of CR and presence of MRD at the time of alloHCT. Further studies should focus on optimizing post-alloHCT outcomes for patients with responses less than CR.
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