| 1. |
- Wheelwright, S, et al.
(författare)
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International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer.
- 2013
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Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 109:4, s. 852-8
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Tidskriftsartikel (refereegranskat)abstract
- Background:Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC's core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods:Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test-retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).Results:Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test-retest and RCA analyses were equivocal.Conclusion:The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients' self-reported HRQOL may be related to both cancer evolution and non-clinical events.
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| 2. |
- Brons, Maaike, et al.
(författare)
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Patterns in the Use of Heart Failure Telemonitoring: Post Hoc Analysis of the e-Vita Heart Failure Trial
- 2023
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Ingår i: JMIR cardio. - : JMIR Publications. - 2561-1011. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Research on the use of home telemonitoring data and adherence to it can provide new insights into telemonitoring for the daily management of patients with heart failure (HF). Objective: We described the use of a telemonitoring platform—including remote patient monitoring of blood pressure, pulse, and weight—and the use of the electronic personal health record. Patient characteristics were assessed in both adherent and nonadherent patients to weight transmissions. Methods: We used the data of the e-Vita HF study, a 3-arm parallel randomized trial performed in stable patients with HF managed in outpatient clinics in the Netherlands. In this study, data were analyzed from the participants in the intervention arm (ie, e-Vita HF platform). Adherence to weight transmissions was defined as transmitting weight ≥3 times per week for at least 42 weeks during a year. Results: Data from 150 patients (mean age 67, SD 11 years; n=37, 25% female; n=123, 82% self-assessed New York Heart Association class I-II) were analyzed. One-year adherence to weight transmissions was 74% (n=111). Patients adherent to weight transmissions were less often hospitalized for HF in the 6 months before enrollment in the study compared to those who were nonadherent (n=9, 8% vs n=9, 23%; P=.02). The percentage of patients visiting the personal health record dropped steadily over time (n=140, 93% vs n=59, 39% at one year). With univariable analyses, there was no significant correlation between patient characteristics and adherence to weight transmissions. Conclusions: Adherence to remote patient monitoring was high among stable patients with HF and best for weighing; however, adherence decreased over time. Clinical and demographic variables seem not related to adherence to transmitting weight.Trial Registration: ClinicalTrials.gov NCT01755988; https://clinicaltrials.gov/ct2/show/NCT01755988
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| 3. |
- Den Ouden, M. A. G., et al.
(författare)
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Stand-alone single-frequency GPS ice velocity observations on Nordenskiöldbreen, Svalbard
- 2010
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Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0416 .- 1994-0424. ; 4:4, s. 593-604
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Tidskriftsartikel (refereegranskat)abstract
- Precise measurements of ice-flow velocities are necessary for a proper understanding of the dynamics of glaciers and their response to climate change. We use stand-alone single-frequency GPS receivers for this purpose. They are designed to operate unattended for 1–3 years, allowing uninterrupted measurements for long periods with hourly temporal resolution. We present the system and illustrate its functioning using data from 9 GPS receivers deployed on Nordenskiöldbreen, Svalbard, for the period 2006–2009. The accuracy of the receivers is 1.62 m based on the standard deviation in the average location of a stationary reference station (NBRef). Both the location of NBRef and the observed flow velocities agree within one standard deviation with DGPS measurements. Periodicity (6, 8, 12, 24 h) in the NBRef data is largely explained by the atmospheric, mainly ionospheric, influence on the GPS signal. A (weighed) running-average on the observed locations significantly reduces the standard deviation and removes high frequency periodicities, but also reduces the temporal resolution. Results show annual average velocities varying between 40 and 55 m yr−1 at stations on the central flow-line. On weekly to monthly time-scales we observe a peak in the flow velocities (from 60 to 90 m yr−1) at the beginning of July related to increased melt-rates. No significant lag is observed between the timing of the maximum speed between different stations. This is likely due to the limited temporal resolution after averaging in combination with the relatively small distance (max. ±13 km) between the stations.
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| 4. |
- Oerlemans, J., et al.
(författare)
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Reconstructing the glacier contribution to sea-level rise back to 1850
- 2007
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Ingår i: CRYOSPHERE. - 1994-0416. ; 1:1, s. 59-65
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Tidskriftsartikel (refereegranskat)abstract
- We present a method to estimate the glacier contribution to sea-level rise from glacier length records. These records form the only direct evidence of glacier changes prior to 1946, when the first continuous mass-balance observations began. A globally representative length signal is calculated from 197 length records from all continents by normalisation and averaging of 14 different regions. Next, the resulting signal is calibrated with mass-balance observations for the period 1961-2000. We find that the glacier contribution to sea level rise was 5.5 +/- 1.0 cm during the period 1850-2000 and 4.5 +/- 0.7 cm during the period 1900-2000.
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| 5. |
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| 6. |
- van Pelt, Ward, et al.
(författare)
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An iterative inverse method to estimate basal topography and initialize ice flow models
- 2013
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Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0416 .- 1994-0424. ; 7:3, s. 987-1006
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Tidskriftsartikel (refereegranskat)abstract
- We evaluate an inverse approach to reconstruct distributed bedrock topography and simultaneously initialize an ice flow model. The inverse method involves an iterative procedure in which an ice dynamical model (PISM) is run multiple times over a prescribed period, while being forced with space-and time-dependent climate input. After every iteration bed heights are adjusted using information of the remaining misfit between observed and modeled surface topography. The inverse method is first applied in synthetic experiments with a constant climate forcing to verify convergence and robustness of the approach in three dimensions. In a next step, the inverse approach is applied to Nordenskioldbreen, Svalbard, forced with height-and time-dependent climate input since 1300 AD. An L-curve stopping criterion is used to prevent overfitting. Validation against radar data reveals a high correlation (up to R = 0.89) between modeled and observed thicknesses. Remaining uncertainties can mainly be ascribed to inaccurate model physics, in particular, uncertainty in the description of sliding. Results demonstrate the applicability of this inverse method to reconstruct the ice thickness distribution of glaciers and ice caps. In addition to reconstructing bedrock topography, the method provides a direct tool to initialize ice flow models for forecasting experiments.
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