| 1. |
- Ohlsson, Anders, et al.
(författare)
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Shared Reading som litteraturperformance
- 2022
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Ingår i: Shared Reading i Skandinavia : Teori of praksis - Teori of praksis. - 9788293298212 - 9788293298229 ; , s. 63-86
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Bokkapitel (refereegranskat)
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| 2. |
- Ohlsson, Sophie, et al.
(författare)
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Novel distribution of the secretory leucocyte proteinase inhibitor in kidney
- 2001
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Ingår i: Mediators of Inflammation. - : Hindawi Limited. - 0962-9351 .- 1466-1861. ; 10:6, s. 347-350
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Tidskriftsartikel (refereegranskat)abstract
- The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.
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| 3. |
- Abrahamson, Magnus, et al.
(författare)
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Human cystatin C: Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase
- 1991
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Ingår i: Biochemical Journal. - 0264-6021. ; 273:3, s. 621-626
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Tidskriftsartikel (refereegranskat)abstract
- Leucocyte elastase in catalytic amounts was observed to rapidly cleave the Val-10-Gly-11 bond of the human cysteine-proteinase inhibitor cystatin C at neutral pH. The resulting modified inhibitor had size and amino acid composition consistent with a cystatin C molecule devoid of the N-terminal Ser-1-Val-10 decapeptide. Leucocyte-elastase-modified cystatin C had more than 240-fold lower affinity than native cystatin C for papain. Removal of the N-terminal decapeptide of human cystatin C also decreased inhibition of human cathepsins B and L by three orders of magnitude, but decreased inhibition of cathepsin H by only 5-fold. A tripeptidyldiazomethane analogue of of the N-terminal portion of cystatin C was a good inhibitor of cathepsins B and L but a poor inhibitor of cathepsin H. It therefore appears that amino acid side chains of the N-terminal segment of cystatin C bind in the substrate-binding pockets of cathepsins B and L but not in those of cathepsin H. It is argued that the N-terminal cystatin C interaction with cathepsin B is physiologically important and hence that leucocyte elastase could have a function as a regulator of extracellular cysteine-proteinase inhibitory activity at sites of inflammation.
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| 4. |
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| 5. |
- Alfredson, Jens, 1970-
(författare)
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Differences in Situational Awareness and How to Manage Them in Development of Complex Systems
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Situationsmedvetenhet (Eng. Situational Awareness), (SA), handlar om att ha koll på läget och vara medveten om vad som händer. Redan då ett komplext system utvecklas får vi en möjlighet att påverka vilken SA en framtida användare av systemet kan komma att få. Det gäller att ta tillvara på detta tillfälle! Ibland uppträder skillnader i SA, beroende på en rad olika orsaker. Denna avhandling handlar om SA och hur man kan använda de skillnaderna vid utveckling av komplexa system. Detta är relevant vid utveckling av en rad olika typer av komplexa system, även om de flesta exempel i denna avhandling kommer från flygdomänen.Avhandlingen innehåller beskrivningar hämtade från litteratur inom området och förslag på utveckling av SA-teori utifrån fokus på just skillnader. Skillnaden mellan vad du behöver vara medveten om och vad du verkligen är medveten om föreslås ge en indikation om individens SA. Vidare föreslås skillnaden mellan vad du är medveten om och vad du tror dig vara medveten om också ge en indikation om individens SA. SA kan skattas för en grupp av människor som arbetar tillsammans, genom variationerna i hur samstämmiga deras uppfattningar är.Termen situationshantering (Eng. Situation Management), (SM), föreslås med en vidare mening än SA, inkluderande SA, men också varje del av perceptionscykeln, hantering av mentala resurser och hantering av situationen genom extern påverkan. SM är en väl lämpad term vid utveckling av komplexa system då fokus här är på situationen och hur den kan hanteras, snarare än fokus på vad en individ eller en grupp uppfattar.Att skatta skillnader i SA och att kunna särskilja olika typer av skillnader är viktiga förutsättningar för att kunna hantera skillnader i SA vid utveckling av komplexa system på ett bra sätt. I avhandlingen gås flera sätt att skatta sådana skillnader igenom och speciellt tas för- och nackdelar med ögonrörelsemätning upp. Med referens till litteraturen och till de bilagda artiklarna beskrivs skillnader i SA beroende på a) designalternativ, b) roller i processen från utveckling till användning c) kontext och d) analysnivå. Skillnaderna i SA föreslås ses som både kvantitativa (dvs. hög eller låg SA) och kvalitativa (tex. olika aspekter av en situation).Ansatser såsom SM, realtidsvärdering, mätning och analys av SA på flera nivåer samtidigt samt simulatorbaserad design föreslås för att hantera skillnader i SA vid utveckling av komplexa system.
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| 6. |
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| 7. |
- Alm, Torbjörn, et al.
(författare)
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Business process reengineering in the automotive area by simulator-based design
- 2007. - 1
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Ingår i: Simulation and Modeling. - Hershey, PA, USA : IGI-Global Inc.. - 9781599041988 - 1599041987 ; , s. 337-358
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The science of simulation and modeling (SM) strives to showcase the highest possible level of reality in order to determine the conditions necessary for optimal performance. SM is a multifaceted and complex field due to the numerous applications involved, particularly since SM applications range from nuclear reaction to supermarket queuing. Simulation and Modeling: Current Technologies and Applications includes examinations of current issues related to simulation such as: Web-based simulation, virtual reality, augmented reality, and artificial intelligence. This book combines different methods, views, theories, and applications of simulations into one volume, and offers insight into the computer science aspect of simulation and modeling while integrating the business practices of SM.
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| 8. |
- Alm, Torbjörn, et al.
(författare)
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Continuous versus Situation-dependent Night Vision Presentation in Automotive Applications
- 2006
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Konferensbidrag (refereegranskat)abstract
- As the number of advanced driver assistance systems in modern cars increases the question of possible negative behavioral adaptation is raised. We have investigated this phenomenon for night vision systems in a driving simulator. One common opinion is that there is a risk for using the enhanced visual conditions that come with these systems to increase speed during nighttime driving and thereby eliminate the safety margins the system was designed to provide. In our study two system approaches were compared, one with continuous presentation and one with presentation only when dangerous objects were detected by the system. The latter approach was meant to minimize the risk of negative adaptation, which was partly confirmed in the study. Moreover, the results showed better and more consistent driver performance with the situation-dependent system and all subjects preferred this approach from a workload perspective.
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| 9. |
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| 10. |
- Alm, Torbjörn, 1941-
(författare)
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Simulator-Based Design : Methodology and vehicle display application
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Human-in-the-loop simulators have long been used in the research community as well as in industry. The aviation field has been the pioneers in the use of simulators for design purposes. In contrast, corresponding activities in the automotive area have been less widespread. Published reports on experimental activities based on human-in-the-loop simulations have focused on methods used in the study, but nobody seems to have taken a step back and looked at the wider methodological picture of Simulator-Based Design. The purpose of this thesis is to fill this gap by drawing, in part, upon the author’s long experience in this field.In aircraft and lately also in ground vehicles there has been a technology shift from pure mechanics to computer-based systems. The physical interface has turned into screen-based solutions. This trend towards glass has just begun for ground vehicles. This development in vehicle technology has opened the door for new design approaches, not only for design itself, but also for the development process. Simulator-Based Design (SBD) is very compatible with this trend. The first part of this thesis proposes a structure for the process of SBD and links it to the corresponding methodology for software design.In the second part of the thesis the focus changes from methodology to application and specifically to the design of three-dimensional situation displays. Such displays are supposed to support the human operator with a view of a situation beyond the more or less limited visual range. In the aircraft application interest focuses on the surrounding air traffic in the light of the evolving free-flight concept, where responsibility for separation between aircraft will be (partly) transferred from ground-based flight controllers to air crews. This new responsibility must be supported by new technology and the situational view must be displayed from the perspective of the aircraft. Some basic design questions for such 3D displays were investigated resulting in an adaptive interface approach, where the current situation and task govern the details of information presentation.The thesis also discusses work on situation displays for ground vehicles. The most prominent example may be the Night Vision system, where the road situation ahead is depicted on a screen in the cab. The existing systems are based on continuous presentation, an approach that we have questioned, since there is strong evidence for negative behavioral adaptation. This means, for example, that the driver will drive faster, since vision has been enhanced, and thereby consume the safety margins that the system was supposed to deliver. Our investigation supports a situation-dependant approach and no continuous presentation.In conclusion, the results from our simulator-based studies showed advantages for adaptive interface solutions. Such design concepts are much more complicated than traditional static interfaces. This finding emphasizes the need for more dynamic design resources in order to have a complete understanding of the situation-related interface changes. The use of human-in-the-loop simulators and deployment of Simulator-Based Design will satisfy this need.
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| 11. |
- Andersson, Niklas, 1970, et al.
(författare)
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Pharmacological treatment of osteopenia induced by gastrectomy or ovariectomy in young female rats.
- 2004
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Ingår i: Acta orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470 .- 1651-1964. ; 75:2, s. 201-9
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Both gastrectomy (GX) and ovariectomy (OVX) induce osteopenia in man and experimental animals. The present study addresses the question--can alendronate, estrogen or parathyroid hormone (PTH) be used to treat established GX- or OVX -evoked osteopenia? METHODS: Rats were GX-, OVX- or SHAM-operated 8 weeks before starting the treatment with drugs. Each group was then treated for 8 weeks with 50 microg/kg/day alendronate, 10 microg/kg/day estrogen or 75 microg/kg/day PTH(1-84); n = 8 rats/group. Peripheral Quantitative Computed Tomography (pQCT) was used to measure trabecular bone mineral density (BMD) and various cortical bone parameters. RESULTS: At killing, 16 weeks after surgery, GX and OVX rats had a greatly reduced trabecular BMD in the metaphysis of the distal femur (GX -44% and OVX -55%). Alendronate increased the trabecular BMD by 44% in GX rats and by 64% in OVX rats, while PTH increased it by 51% and 115%, respectively. However, estrogen increased the trabecular BMD in GX rats (35%), but not in OVX rats (15%, not significant). Cortical bone parameters were adversely (but moderately) affected by GX, but not by OVX or by treatment with the three drugs. INTERPRETATION: Alendronate, estrogen and PTH restored the trabecular bone loss in rats with an established GX-evoked osteopenia. In contrast, alendronate and PTH, but not estrogen, restored the trabecular bone loss after OVX. Hence, the mechanism underlying GX-evoked bone loss differs from that underlying OVX-evoked bone loss. The ability of alendronate, estrogen and PTH to reverse the GX-evoked osteopenia in the rat may be of clinical interest when dealing with bone loss in humans after GX.
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| 12. |
- Arvola, Mattias, 1975-
(författare)
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Good to use! : Use quality of multi-user applications in the home
- 2003
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Traditional models of usability are not sufficient for software in the home, since they are built with office software in mind. Previous research suggest that social issues among other things, separate software in homes from software in offices. In order to explore that further, the use qualities to design for, in software for use in face-to-face meetings at home were contrasted to such systems at offices. They were studied using a pluralistic model of use quality with roots in socio-cultural theory, cognitive systems engineering, and architecture. The research approach was interpretative design cases. Observations, situated interviews, and workshops were conducted at a Swedish bank, and three interactive television appliances were designed and studied in simulated home environments. It is concluded that the use qualities to design for in infotainment services on interactive television are laidback interaction, togetherness among users, and entertainment. This is quite different from bank office software that usually is characterised by not only traditional usability criteria such as learnability, flexibility, effectiveness, efficiency, and satisfaction, but also professional face management and ante-use. Ante-use is the events and activities that precedes the actual use that will set the ground for whether the software will have quality in use or not. Furthermore, practices for how to work with use quality values, use quality objectives, and use quality criteria in the interaction design process are suggested. Finally, future research in design of software for several co-present users is proposed.
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| 13. |
- Arvola, Mattias, 1975-
(författare)
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Shades of Use : The Dynamics of Interaction Design for Sociable Use
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Computers are used in sociable situations, for example during customer meetings. This is seldom recognized in design, which means that computers often become a hindrance in the meeting. Based on empirical studies and socio-cultural theory, this thesis provides perspectives on sociable use and identifies appropriate units of analysis that serve as critical tools for understanding and solving interaction design problems. Three sociable situations have been studied: customer meetings, design studios and domestic environments. In total, 49 informants were met with during 41 observation and interview sessions and 17 workshops; in addition, three multimedia platforms were also designed. The empirical results show that people need to perform individual actions while participating in joint action, in a spontaneous fashion and in consideration of each other. The consequence for design is that people must be able to use computers in different manners to control who has what information. Based on the empirical results, five design patterns were developed to guide interaction design for sociable use. The thesis demonstrates that field studies can be used to identify desirable use qualities that in turn can be used as design objectives and forces in design patterns. Re-considering instrumental, communicational, aesthetical, constructional and ethical aspects can furthermore enrich the understanding of identified use qualities. Witha foundation in the field studies, it is argued that the deliberation of ynamic characters and use qualities is an essential component of interaction design. Designers of interaction are required to work on three levels: the user interface, the mediating artefact and the activity of use. It is concluded that doing interaction design is to provide users with perspectives, resources and constraints on their space for actions; the complete design is not finalized until the users engage in action. This is where the fine distinctions and, what I call 'shades of use' appear.
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| 14. |
- Berglund, Erik, 1971-
(författare)
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Library Communication Among Programmers Worldwide
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Programmers worldwide share components and jointly develop components on a global scale in contemporary software development. An important aspect of such library-based programming is the need for technical communication with regard to libraries – library communication. As part of their work, programmers must discover, study, and learn as well as debate problems and future development. In this sense, the electronic, networked media has fundamentally changed programming by providing new mechanisms for communication and global interaction through global networks such as the Internet. Today, the baseline for library communication is hypertext documentation. Improvements in quality, efficiency, cost and frustration of the programming activity can be expected by further developments in the electronic aspects of library communication.This thesis addresses the use of the electronic networked medium in the activity of library communication and aims to discover design knowledge for communication tools and processes directed towards this particular area. A model of library communication is provided that describes interaction among programmer as webs of interrelated library communities. A discussion of electronic, networked tools and processes that match such a model is also provided. Furthermore, research results are provided from the design and industrial valuationof electronic reference documentation for the Java domain. Surprisingly, the evaluation did not support individual adaptation (personalization). Furthermore, global library communication processes have been studied in relation to open-source documentation and user-related bug handling. Open-source documentation projects are still relatively uncommon even in open-source software projects. User-related Open-source does not address the passive behavior users have towards bugs. Finally, the adaptive authoring process in electronic reference documentation is addressed and found to provide limited support for expressing the electronic, networked dimensions of authoring requiring programming skill by technical writers.Library communication is addressed here by providing engineering knowledge with regards to the construction of practical electronic, networked tools and processes in the area. Much of the work has been performed in relation to Java library communication and therefore the thesis has particular relevancefor the object-oriented programming domain. A practical contribution of the work is the DJavadoc tool that contributes to the development of reference documentation by providing adaptive Java reference documentation.
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| 15. |
- Bernhardsson, Katarina, et al.
(författare)
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Obduktion och mjuka texter : Shared Reading som metod på universitetet
- 2022
-
Ingår i: Shared Reading i Skandinavia : Forskning og praksis - Forskning og praksis. - 9788293298212 - 9788293298229 ; , s. 257-287
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Bokkapitel (refereegranskat)abstract
- This chapter discusses how Shared Reading (SR) can be used as a method when teaching university students in professional education. Drawing on experiences from both the Medical School and the Creative Writing Program, the chapter shows how SR can be used to enhance professional development in two different settings. In Medical School, SR is used to create a space for exploration of relational and emotional aspects of the profession, which is here exemplified with the reading of poetry after the students’ first autopsy. In the Creative Writing Program, SR is used to slow down the reading, giving the students the opportunity to read the text as if it was still a work-in-progress, and a so-called ‘flexible’ text. The discussion shows the versatility of the method: how as, even as the method is the same, the differences come from the educational context, and what the students learn is to a large extent dependent on their future profession.
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| 16. |
- Björk, Peter, et al.
(författare)
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Release of dog polymorphonuclear leukocyte cathepsin g, normally and in endotoxin and pancreatitic shock : Isolation and partial characterization of dog polymorphonuclear leukocyte cathepsin g
- 1991
-
Ingår i: Biological Chemistry Hoppe-Seyler. - : Walter de Gruyter GmbH. - 0177-3593. ; 372:1, s. 419-426
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Tidskriftsartikel (refereegranskat)abstract
- Dog polymorphonuclear leukocyte cathepsin G was isolated from a granule extract using a two-step procedure including affinity chromatography on aTrasylol-Sepharose gel and ion-exchange chromatography on a CM 52 column. 22 of the first 24 N-terminal amino acids were determined and showed 83% and 71% identity to those of human and rat cathepsin G, respectively. Total amino-acid composition demonstrated the basic nature of the protein. In an SDS/polyacrylamide-gel electrophoresis the protein showed an Mr of 29400 compared to the Mr of 26800 calculated from the total amino-acid composition. The enzyme was shown to form complexes with α1α2-macroglobulin and arproteinase inhibitor. A specific enzyme-linked immunosorbent assay was developed for the determination of cathepsin G/α proteinase inhibitor complex in dog plasma and tissue fluids. The mean concentration of cathepsin G in normal dog plasma was determined to be 38 μ/l, measured as cathepsin G/α1-proteinase inhibitor complex. When active dog cathepsin G was added to normal dog plasma in vitro, approximately 56% could be measured by the assay. Slow intravenous infusion of a lethal dose of endotoxin in dogs was followed by a marked drop in white blood cell count and thrombocytes and a simultaneous rapid increase in plasma cathepsin G concentration, reaching a maximum level of 150 β/l. Bile-induced experimental pancreatitis in dogs was accompanied by successive increase in cathepsin G levels in plasma as well as in peritoneal exudates, reaching a maximum level of about 300 μ/l in plasma and 18 mg/ l in the exudates during the late stages of disease. & by Walter de Gruyter & Co
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| 17. |
- Bläckberg, Mats, et al.
(författare)
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Interactions in vitro and in vivo between porcine tissue kallikrein and porcine plasma proteinase inhibitors
- 1994
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Ingår i: Scandinavian Journal of Clinical & Laboratory Investigation. - : Informa UK Limited. - 1502-7686 .- 0036-5513. ; 54:8, s. 643-651
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Tidskriftsartikel (refereegranskat)abstract
- The elimination of radio-iodinated porcine tissue kallikrein, after intravenous injection in the pig, showed a rapid initial clearance from plasma (T1/2 approximately 10min), followed by a phase of slower elimination (T1/2 approximately 100min). Gel filtration of plasma samples showed complexes with alpha1-alpha2-macroglobulin (A1a2-M) and alpha1-proteinase inhibitor (A1PI), which decreased with time. The urinary excretion of undegraded tissue kallikrein was about 1.8%. Gel filtration of urine showed a minor peak representing free tissue kallikrein and a major peak representing degradation products. On average, 8.3% was found in the liver and 1.3% in the kidneys post mortem, indicating that these are the primary organs for the elimination of tissue kallikrein.The in vivo findings were supported by in vitro experiments. A1a2-M were found to be the major inhibitors of tissue kallikrein, when a mixture of the enzyme and porcine plasma was analysed by gel filtration, Immunoelectrophoresis, crossed Immunoelectrophoresis and autoradiography. A1PI was only a minor inhibitor of tissue kallikrein. Both the A1a2-M and A1-PI complex formation was found to be time-dependent and slow; unbound glandular kallikrein was still detected after 12h, even when there was a molar surplus of A1-M and A1PI. The complexes with A1a2-M and the unbound tissue kallikrein were found to be enzymatically active against low-molecular-weight chromogenic substrate. The total tissue kallikrein-inhibiting capacity of plasma seemed to be exceeded at a concentration of 800 KU/1 when analysed using the rat uterus bioassay.A1a2-M appears to be the major inhibitor of tissue kallikrein in plasma and the complexes are removed mainly by the reticulo-endothelial system, such as that in the liver.
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| 18. |
- Bläckberg, Mats, et al.
(författare)
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Studies on the release of tissue kallikrein in experimental pancreatitis in the pig
- 1994
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Ingår i: European Surgical Research. - : S. Karger AG. - 0014-312X .- 1421-9921. ; 26:2, s. 116-124
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Tidskriftsartikel (refereegranskat)abstract
- The activation of the kallikrein-kinin system is thought to be one of the pathophysiological factors in acute pancreatitis. A radioimmunoassay for porcine, pancreatic tissue kallikrein was developed and used to measure levels in normal plasma and peritoneal fluid and in experimental, bile-induced (group A) and bile trypsin-induced (group B) acute pancreatitis in the pig. Normal porcine plasma and peritoneal fluid contained about 2.17 +/- 0.11 and 1.91 +/- 0.19 microgram/l (SEM) tissue kallikrein, respectively. In experimental, acute pancreatitis there was a rapid rise in the plasma level of tissue kallikrein, followed by a slow increase to a final value of about 150% of the normal plasma level in both groups. In the peritoneal exudate a large increase (200-fold in group A and 2,000-fold in group B) in tissue kallikrein was seen, with a maximum within about 1/3 of the survival time, followed by a slow decrease until death in group B. In group A a smaller second peak was seen at about 2/3 of the survival time. Gelfiltration of peritoneal exudates showed complexes with alpha 1-, alpha 2-macroglobulin (alpha 1 alpha 2-M), and alpha 1-proteinase inhibitor (alpha 1-PI) and a large portion of free tissue kallikrein. The complexes with alpha 1 alpha 2-M and the free tissue kallikrein were found to be enzymatically active when tested on chromogenic tripeptide substrate. The presence of large amounts of free and active tissue kallikrein in the peritoneal exudate leads us to the conclusion that tissue kallikrein may be a major cause of local release of kinins in acute pancreatitis.
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| 19. |
- Bläckberg, Mats, et al.
(författare)
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Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin
- 1999
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Ingår i: Pancreas. - 0885-3177. ; 19:4, s. 325-334
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Tidskriftsartikel (refereegranskat)abstract
- The activation of the kallikrein-kinin system is thought to be one of the pathophysiologic mechanisms in acute pancreatitis. A radioimmunoassay for human urinary tissue kallikrein was developed and used to measure tissue kallikrein peritoneal exudate and plasma from 48 patients with severe acute pancreatitis. All patients were treated with intraperitoneal lavage. One group (n = 22) received high doses of the protease inhibitor aprotinin (aprotinin group), and the other group, saline (control group). Levels of kallistatin in peritoneal exudates and plasma were measured with an enzyme immunoassay. A large increase in tissue kallikrein was observed in the peritoneal exudate, which declined in both groups after multiple lavages. Complexing of liberated tissue kallikrein with kallistatin was evidenced by gel filtration in both peritoneal exudates and plasma in both groups. The decrease in kallistatin observed in both peritoneal exudate and plasma is therefore regarded as being due not only to repeated lavage, but also to true consumption of the binding protein. Some of the liberated tissue kallikrein in the peritoneal fluid and plasma was complexed to aprotinin. In the control group, six patients were operated on because of pancreatic necrosis, compared with none in the aprotinin group. The levels of tissue kallikrein in the lavage fluid were lower in the control group, but this was the result of the very low tissue kallikrein values in the six patients operated on for pancreatic necrosis. Levels of kallistatin in plasma and peritoneal exudate in these six patients were lower on the day of admission compared with the other patients, and the plasma levels continued to be lower during the first week. Large amounts of tissue kallikrein were found to be released into the peritoneal exudates in acute pancreatitis. Lavages effectively cleared the released tissue kallikrein. The tissue kallikrein was complexed to kallistatin, whereas in the aprotinin group, also to aprotinin both in plasma and in peritoneal fluid. The partitioning of kallikrein between the two inhibitors was the result of the interaction between enzyme and inhibitors and the turnover of the complexes formed. The low admission levels of kallistatin in the six patients operated on because of pancreatic necrosis suggest that kallistatin may act as an early marker of severity in acute pancreatitis.
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| 20. |
- Brun, Eva, et al.
(författare)
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Early prediction of treatment outcome in head and neck cancer with 2-18FDG PET
- 1997
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 36:7, s. 741-747
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Tidskriftsartikel (refereegranskat)abstract
- The development of alternative treatment regimens in clinical oncology has increased the need for early prediction of cancer therapy outcome. The aim of this study was, early in the treatment phase, to identify patients with advanced head and neck cancer, responding or not responding to initiated therapy. The tumour metabolic rate of glucose (MRgl) examined by 2-18FDG-PET was determined in 17 patients before and after the first weeks of either radiotherapy (16-35 Gy) or one course of combination chemotherapy. Metabolic values uptake values normalized to plasma activity integrals--were correlated to loco-regional outcome, as evaluated 5-6 weeks after completion of treatment. Initial low tumour MRgl (<20 micromol/min/100 g tissue), in primary lesions or regional metastases, predicted a local complete response. When a high initial tumour MRgl was found, the magnitude of the reduction of MRgl in the second PET examination might be an adjunct in predicting local tumour response.
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| 21. |
- Castor, Martin, 1972-
(författare)
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The use of structural equation modeling to describe the effect of operator functional state on air-to-air engagement outcomes
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Computational evidence of the operative usefulness of a new system is crucial in large system development processes concerning billions of euros or dollars. Although it is obvious that the human often is the most important and critical component of many systems, it has often been hard for Human Factors researchers to express human aspects in a computational and strict way. The thesis describes, through data based statistical modeling, how the concepts or constructs of sensor effectiveness, usability of information, mental workload, situation awareness and teamwork relates to each other and to the operative performance in a fourship of fighter pilots. Through the use of structural equation modeling, ad modum LISREL, a statistical model that describes how the operators’ functional state mediates the effects between technical system oriented variables, was developed.The constructs used in the modeling process have received widespread scientific and operational attention. They have also been identified as multi-dimensional. Many different ways of measuring them have been developed in the scientific community, and the thesis focuses on the next step, i.e. how do these higher order constructs relate to each other in something as multi-dimensional as human activity in real situations?A comprehensive human factors related dataset was collected in a large simulation based acquisition study that examined the requirements and properties of aircraft radar systems. The dataset contains 308 simulated engagements with data from four pilots each, i.e. 1232 cases in a database with 24 variables, generated by 37 pilots. The collected data and the resulting models thus summarizes more than 700 hours of experienced pilots’ complex behavior in an operationally valid environment, and in a way that is of theoretical interest as well as of importance in system development processes. The data thus comes from a real world study of complex processes in a dynamic context, although from a simulator. The thesis is a case example of modern ecologically valid experimental psychology. The data collection does not represent a classical experimental setup, but instead demonstrates methodological needs and considerations for human factors practitioners when working in system development studies. The fact that parts of the used data are classified has not affected the models and scientific conclusions, although the practical findings have been partly circumscribed in the presentation.As a result of the statistical modeling effort, a structural equation model of how the chosen constructs relate to each other, and mediate effects between technical measures by a model of the operator, is proposed. Simplicity of the model was the goal, and based on former experiences and findings, a simplex structure was hypothesized. The final model shows that the covariances between the 24 measures can be explained by a quasi-simplex structure of seven factors.
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| 22. |
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| 23. |
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| 24. |
- Danielsson, Mats, et al.
(författare)
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Decision making in emergency management : a survey study
- 1999
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Ingår i: International Journal of Cognitive Ergonomics. - : Informa UK Limited. - 1088-6362 .- 1532-7566. ; 3:2, s. 91-99
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Tidskriftsartikel (refereegranskat)abstract
- Surveyed 89 fire chiefs (aged 33-62 yrs) about their own accounts of factors affecting the difficulty level of decision making during major emergencies. The purpose of the survey was to uncover the needs and necessary conditions for implementation of decision support systems that would enhance emergency operation performance. Interview data revealed that setting priorities in lifesaving operations and evacuations, and whether to adopt an offensive or defensive fire fighting strategy were perceived as the most difficult types of decision tasks. Perceived stressors related to lack of information during the initial phase of an emergency response. Emergency management, being a control task, is analyzed within the framework of distributed dynamic decision making. Information needs differ according to the decision-maker's position in the distributed system. A model for evaluation of information transmitted to the emergency management system is proposed
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| 25. |
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| 26. |
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Ekerstad, Niklas, et al.
(författare)
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Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction
- 2022
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Ingår i: European Heart Journal. - : Oxford University Press. - 2048-8726 .- 2048-8734. ; 11:2, s. 89-98
-
Tidskriftsartikel (refereegranskat)abstract
- Aims: Data on the prognostic value of frailty to guide clinical decision-making for patients with myocardial infarction (MI) are scarce. To analyse the association between frailty classification, treatment patterns, in-hospital outcomes, and 6-month mortality in a large population of patients with MI.Methods and results: An observational, multicentre study with a retrospective analysis of prospectively collected data using the SWEDEHEART registry. In total, 3381 MI patients with a level of frailty assessed using the Clinical Frailty Scale (CFS-9) were included. Of these patients, 2509 (74.2%) were classified as non-vulnerable non-frail (CFS 1–3), 446 (13.2%) were vulnerable non-frail (CFS 4), and 426 (12.6%) were frail (CFS 5–9). Frailty and non-frail vulnerability were associated with worse in-hospital outcomes compared with non-frailty, i.e. higher rates of mortality (13.4% vs. 4.0% vs. 1.8%), cardiogenic shock (4.7% vs. 2.5% vs. 1.9%), and major bleeding (4.5% vs. 2.7% vs. 1.1%) (allP < 0.001), and less frequent use of evidence-based therapies. In Cox regression analyses, frailty was strongly and independently associated with 6-month mortality compared with non-frailty, after adjustment for age, sex, the GRACE risk score components, and other potential risk factors [hazard ratio (HR) 3.32, 95% confidence interval (CI) 2.30–4.79]. A similar pattern was seen for vulnerable non-frail patients (fully adjusted HR 2.07, 95% CI1.41–3.02).Conclusion: Frailty assessed with the CFS was independently and strongly associated with all-cause 6-month mortality, also after comprehensive adjustment for baseline differences in other risk factors. Similarly, non-frail vulnerability was independently associated with higher mortality compared with those with preserved functional ability.
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| 31. |
- Filla, Reno, et al.
(författare)
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A Case Study on Quantifying the Workload of Working Machine Operators by Means of Psychophysiological Measurements
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this study of eighteen wheel loader operators, test-driving a machine in three different traction force settings, we examine if a workload index derived from psychophysiological measurements of heart rate, finger temperature, skin conductance, respiration rate and end-tidal CO2-concentration in exhaled air can be used to assess operator workload in sufficient detail to use it as a complement to traditional subjective evaluations, and also to use such measurements in a workload-adaptive operator assistance system in a longer perspective.
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| 32. |
- Filla, Reno, et al.
(författare)
-
A Case Study on Quantifying the Workload of Working Machine Operators by Means of Psychophysiological Measurements
- 2013
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Konferensbidrag (refereegranskat)abstract
- In this study of eighteen wheel loader operators, test-driving a machine in three different traction force settings, we examine if a workload index derived from psychophysiological measurements of heart rate, finger temperature, skin conductance, respiration rate and end-tidal CO2-concentration in exhaled air can be easily used to assess operator workload in sufficient detail to use it as a complement to traditional subjective evaluations in machine testing, either of real machines or in a human-in-the-loop simulator. In a longer perspective, such measurements are expected to play a role in a workload-adaptive operator assistance system.However, the findings do not give support for this vision. Instead they indicate that other types of measurements than what have been used in our study should be employed if ease of use for practitioners such as test engineers is in focus, but also that other factors than just machine operability must be considered to have a great influence on the operator workload.
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| 33. |
- Filla, Reno
(författare)
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Quantifying Operability of Working Machines
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In working machines the human operator is essential for the performance of the total system. Productivity and energy efficiency are both dependent not only on inherent machine properties and working place conditions, but also on how the operator manoeuvres the machine. In order to operate energy-efficient the operator has to experience the machine as harmonic. This is important to consider during the development of such working machines.It is necessary to quantify operability and to include this interaction between the human operator and the machine in both the later stages of a development project (where physical prototypes are evaluated by professional test operators) as well as in the earlier stages like concept design (where only virtual prototypes are available).The influence of the human operator is an aspect that is traditionally neglected in dynamic simulations conducted in concept design, because the modelling needs to be extended beyond the technical system. The research presented in this thesis shows two approaches to rule-based simulation models of a wheel loader operator. Both operator models interact with the machine model just as a human operator does with the actual machine. It is demonstrated that both operator models are able to adapt to basic variations in workplace setup and machine capability. A “human element” can thus be introduced into dynamic simulations of working machines, providing more relevant answers with respect to operator-influenced complete-machine properties such as productivity and energy efficiency.While the influence of the human operator is traditionally ignored when evaluating machine properties in the early stages of the product development process, later stages are very reliant on professional test operators using physical prototypes. The presented research demonstrates how the traditional subjective evaluation of a machine’s operability can be complemented by a calculated measure for the operator’s control effort, derived from the recorded control commands of the machine operator. This control effort measure can also be calculated from the control commands of an operator model in a simulation, such as those presented in this thesis. It thus also allows for an assessment of operability already in the concept design phase.In addition, the results of a study of quantifying operator workload by means of measuring psycho-physiological data such as heart rate variability and respiration rate are presented as the first step towards realising workload-adaptive operator assistance functions. Once fully developed, the method itself can also be used as another complement to the traditional subjective evaluations of operability. This approach can then be applied not only in testing of physical prototypes, but also earlier in the product development process in studies on human-in-the-loop simulators.
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| 34. |
- Flodmark, Carl-Erik, et al.
(författare)
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Fokus på fetma i familjen
- 1995
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Ingår i: Familjeterapi tillämpningar ur ett svenskt perspektiv. - 9789144469119 ; , s. 54-54
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 35. |
- Flöter, A, et al.
(författare)
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Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women.
- 2005
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Ingår i: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. - : Informa UK Limited. - 0951-3590. ; 20:3, s. 155-60
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate the effect of adding testosterone undecanoate 40 mg daily to estrogen therapy on bone markers, bone mineral density and body composition in oophorectomized women. METHODS: Fifty women, 45-60 years old, who had undergone a hysterectomy and bilateral salpingo-oophorectomy for benign disorders, were randomly assigned to oral treatment with testosterone undecanoate 40 mg plus estradiol valerate 2 mg daily or placebo plus estradiol valerate 2 mg daily. Twenty-four weeks later, cross-over was performed to the other treatment regimen. Forty-four women completed the study. Their serum concentrations of insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, osteocalcin, carboxyterminal telopeptide aminoterminal (ICTP), of type I collagen propeptide of type I procollagen (PICP) and interleukin (IL)-1 receptor antagonist were measured at baseline and after 24 weeks of both treatments, as were also their body mass index (BMI) and blood pressure. Bone mineral density of the total body, spine and hip and total body fat, total lean body mass, trunk fat and trunk lean mass were determined by dual-energy X-ray absorptiometry measurements at baseline and after 24 weeks of both regimens. RESULTS: During treatment, the addition of testosterone counteracted the decrease in IGF-I and PICP seen with estrogen therapy alone. Osteocalcin and ICTP were significantly reduced to the same extent by both therapies. No change ocurred in the IL-1 receptor antagonist. A significant increase was seen in total lean body mass with the estrogen/testosterone regimen, but the total fat mass, trunk lean or fat mass remained unchanged after 24 weeks of both treatments. No effect was detected on total, hip or spinal bone mineral density after treatment with estrogen alone or estrogen/testosterone. Likewise, BMI and blood pressure were unaffected. CONCLUSIONS: The addition of testosterone to oral estrogen might have positive effects on bone as suggested by the fact that it counteracted the decline in IGF-I and PICP levels. An anabolic effect on muscle was reflected by an increase in the total lean body mass. No adverse effects were noted on BMI, fat distribution or blood pressure during the 6-month treatment with oral testosterone undecanoate.
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| 36. |
- Harms-Ringdahl, Lars, et al.
(författare)
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Approaches to accident prevention : a comparative study of eleven Swedish authorities
- 1995
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Ingår i: Safety Science. - : Elsevier BV. - 0925-7535 .- 1879-1042. ; 21:1, s. 51-63
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Tidskriftsartikel (refereegranskat)abstract
- A comparison has been made between 11 Swedish authorities involved in accident prevention. The authorities' fields of responsibility were in industry, transportation, the environment, and medical care. The aim of the investigation has been to examine approaches to and methods for the prevention of accidents. Representatives from the authorities participated in three seminars and responded to a questionnaire. There are several issues and problems which are of common concern to the authorities. A majority state that one of their greatest problems is to get the "object" of their surveillance to take responsibility, act in a committed manner and work systematically. Also, nearly all state that there are safety problems with computer-controlled equipment and with demands imposed on individuals, e.g., skills demands. At a majority of the authorities, development is in progress of methodologies to be utilized in safety matters. This applies, for example, to the investigation of accidents, surveillance and inspection, and the scrutiny of results from safety analyses. There did not seem to be any appreciable collaboration between authorities across sectoral boundaries with regard to development aimed at safety issues. However, a need for such collaboration appeared to have advantages. Only a few of the authorities gave prominence to contacts with the international scientific community as a means for improving their approaches and working methods in relation to safety.
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| 37. |
- Hyllengren, Peder, et al.
(författare)
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Contextual factors affecting moral stress : a study of military and police officers
- 2016
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Ingår i: International journal of public leadership. - 2056-4929. ; 12:4, s. 275-288
-
Tidskriftsartikel (refereegranskat)abstract
- PurposeThe purpose of this paper is to identify and gain a deeper understanding of environmental, organizational, and group conditions, and leadership-related issues in particular, in severely stressful situations involving a moral stressor faced by military and police officers.Design/methodology/approachA combined deductive and inductive approach was used, and in total 23 military and police officers, all having experience of morally difficult decisions during severely stressful conditions, were interviewed.FindingsA hierarchical conceptual framework of contextual characteristics was developed. The environmental, organizational, leadership-related, and group aspects identified in this study on morally stressful situations resemble findings from general research on work and stress. However, a stronger emphasis was put on leaders’ handling of values and his or her ability to confront senior management when needed.Practical implicationsThe results suggest that well-documented methods aimed at the prevention of, and recovery from, work-related stress, also can be used in the case of extreme situations involving moral stressors.Originality/valueThe interplay between leadership and extreme situations involving moral stressors is, to the best of the knowledge, understudied.
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| 38. |
- Jakobsson, Jenny, et al.
(författare)
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Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.
- 2006
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 91:2, s. 687-93
-
Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: The reproductive endocrinology in Asians and Caucasians is of great interest in view of large differences in prostate cancer rate and sensitivity to pharmacological male contraception. In addition, interpretation of certain antidoping tests is confounded by interethnic variation in androgen disposition. Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene. OBJECTIVE: The objective of the study was to evaluate the contribution of the UGT2B17 deletion polymorphism to the interindividual and interethnic variation of androgen metabolism and excretion. METHODS AND RESULTS: Urine from 122 Swedish and 74 Korean healthy men was analyzed for several androgen glucuronides including testosterone. The distribution of the natural logarithms of urinary testosterone concentrations showed a distinct bimodal pattern in both groups, suggesting a monogenic inheritance. When the UGT2B17 genotypes were compared with urinary testosterone levels, all of the individuals of the UGT2B17 homozygous deletion/deletion genotype had no or negligible amounts of urinary testosterone. The deletion/deletion genotype was seven times more common in the Korean (66.7%) than the Swedish population (9.3%). In addition, the Swedes had significantly higher levels of serum testosterone, compared with the Koreans. CONCLUSIONS: Our results show that the UGT2B17 polymorphism is strongly associated with the bimodal distribution of the testosterone excretion and also with the large differences in testosterone excretion between Koreans and Swedes.
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| 39. |
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| 40. |
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| 41. |
- Jungert, E., et al.
(författare)
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Negotiations in spatial reasoning applications
- 1997
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Ingår i: Proceedings. - Los Alamitos, Calif : IEEE Computer Society Press. ; , s. 222-223
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Konferensbidrag (refereegranskat)abstract
- This paper discusses how a visual language can be developed to assist the user in an interactive approach of horizontal and vertical reasoning for intelligent information retrieval. In addition, it discusses how negotiation can be performed with respect to the spatial and temporal applications, from computer science, cognitive and sociological viewpoints. It also forecasts the future evolution of web oriented meeting system. (3 refs.)
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| 42. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
-
Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 43. |
- Kjellin, Andreas, 1974-
(författare)
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Visualizing Dynamics –The Perception of Spatiotemporal Data in 2D and 3D
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In many command and control situations the understanding of dynamic events is crucial. With today’s development of hard- and software architecture, we have the possibility to visualize data in two-dimensional (2D) and three-dimensional (3D) images. The aim of this thesis is therefore to investigate different approaches to visualizing dynamic events. The visualization techniques investigated include 2D animation and time representations as markings on a 2D map. In 3D the visualization technique investigated is the “space time-cube” A further aim is to study whether the Cue Probability Learning (CPL) paradigm can be used to evaluate visualizations. By mapping time onto a spatial dimension, in the 2D visualization as lines with different densities and in 3D as height over the map, a simultaneous visualization of space and time is possible. The findings are that this mapping of time onto space is beneficial to users as compared with animations, but the two mapping techniques are not interchangeable. If a task requires judgments of metric spatial properties, a 2D visualization is more beneficial; however, if the task only requires judgments of more qualitative aspects, a 3D visualization is more beneficial. When we look at a 3D visualization, we utilize different sources of depth information. These sources are always present and each defines either a 3D scene or a projection surface. By using these different sources of depth information wisely, a visualization can be created that efficiently shows relevant information to a user while requiring a minimal amount of specialized hardware. Finally, the CPL paradigm seems to be a worthwhile option as an experimental paradigm in visualization experiments. One of the advantages of CPL is that novice users can be trained to be task experts in a controlled and time-efficient way.
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| 44. |
- Kovordanyi, Rita, 1964-, et al.
(författare)
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Dynamically Deployed Support as a Potential Solution to Negative Behavioral Adaptation
- 2005
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Ingår i: 2005 IEEE Intelligent Vehicles Symposium Proceedings, 2005. - : IEEE conference proceedings. - 0780389611 ; , s. 613-618
-
Konferensbidrag (refereegranskat)abstract
- Advanced driver assistance systems are designed to make driving easier that is, to alleviate the driver's workload, and to increase traffic safety. However, traffic safety is affected by negative behavioral adaptation, meaning that drivers tend to increase speed and pay less attention to driving when supported by an advanced assistance system. We relate behavioral adaptation to reinforcement learning at a subconscious level, and propose that driver assistance is dynamically varied within predetermined safety limits. The aim of employing a dynamic assistance policy is to prevent the driver from noticing a constant improvement in vehicle handling. We conclude by describing ongoing work for empirically evaluating an improved lane departure warning system that uses a dynamic assistance policy.
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| 45. |
- Kovordanyi, Rita, 1964-, et al.
(författare)
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Night-vision display unlit during uneventful periods may improve traffic safety
- 2006
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Ingår i: 2006 Intelligent Vehicles Symposium sponsored by the IEEE Intelligent Transportation Systems Society,2006. - : IEEE conference proceedings. - 490112286X ; , s. 282-287
-
Konferensbidrag (refereegranskat)abstract
- It is always uncertain if a new assistance system enhances traffic safety or not: empirical studies indicate that driving style may deteriorate when the driver experiences the increased safety margin created by an advanced driver assistance system. To minimize this negative effect on driving style, we redesigned a night vision system so that it appeared differently to the driver: we let the system's head-up display be turned off during operation, to be lit up only when the system detected an obstacle (e.g., a pedestrian or animal) on the road ahead. This presentation style was compared in a simulator study to the traditional solution of constantly lit-up display. The results indicate that drivers reacted more reliably (showed less variance in reaction times) using the new system, which implies that the lighting up of the IR-display constituted an effective warning. Also, drivers to a greater extent drove at normal (slower) speeds when using the re-designed system. More generally, systems offering discontinuous support (i.e. only in critical situations) may have less of a negative effect on driving style, as their presence is not felt as vividly by the driver
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| 46. |
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| 47. |
- Larsson, Gerry, Professor, 1952-, et al.
(författare)
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Stress reactions following acute situations involving moral challenges among health care professionals
- 2018
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 59:2, s. 177-185
-
Tidskriftsartikel (refereegranskat)abstract
- Many health care professionals have to make morally difficult decisions during acute, stressful situations. The aim was to explore the applicability of an existing qualitatively developed model of individual reactions among professional first responders following such situations using a quantitative approach. According to the model, the interaction of antecedent individual and contextual characteristics affect the immediate emotional reactions to acute, stressful events involving a moral dilemma. Continuous coping efforts and the quality of social support will also affect the long‐term positive and negative reactions to the event. The participants (n = 204, about 50% response rate) represented three Swedish health care professions stationed at a university hospital and a regional hospital: Physicians (n = 50), nurses (n = 94) and “others” (n =60, mainly social welfare officers and assistant nurses). Except for the personality dimension emotional stability which was measured using an established instrument, all measurement scales were operationalizations of codes and categories from the qualitative study (ten scales altogether). Four multiple regression analyses were performed with long‐term positive and negative reactions in everyday acute and morally extremely taxing situations respectively as dependent variables. The outcome showed that long‐term positive reactions covaried with much use of the coping strategies Emotional distancing and Constructive emotional confrontation and a perception of a well‐functioning Formal social support. Regarding long‐term negative reactions, higher age and little use of Emotional distancing accounted for much of the variance. Immediate emotional reactions also contributed significantly. Conclusion: the results largely supported the model concepts and their assumed relationships.
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| 48. |
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| 49. |
- Lundberg, Jonas, 1974-
(författare)
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Shaping electronic news : A case study of genre perspectives on interaction design
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis describes and analyzes implications of going from hypertext news to hypermedia news through a process of design, involving users and producers. As in any product development, it is difficult to conceive design of a novel news format that does not relate to earlier genres, and thus to antecedent designs. The hypothesis is that this problem can be addressed by explicitly taking a genre perspective to guide interaction design. This thesis draws on genre theory, which has previously been used in rhetoric, literature, and information systems. It is also informed by theories from humancomputer interaction. The methodological approach is a case study of the ELIN project, in which new tools for online hypermedia newspaper production were developed and integrated. The study follows the project from concept design to interaction design and implementation of user interfaces, over three years. The thesis makes three contributions. Firstly, a genre perspective on interaction design is described, revealing broadly in what respects genre affects design. Secondly, the online newspaper genre is described. Based on a content analysis of online newspaper front-pages, and interviews with users and producers, genre specific design recommendations regarding hypertext news front-page design are given. A content analysis of Swedish online newspapers provides a basis for a design rationale of the context stream element, which is an important part of the news context on article pages. Regarding hypervideo news, design rationale is given for the presentation of hypervideo links, in the context of a hypermedia news site. The impact on news production in terms of dynamics of convergence is also discussed. Thirdly, the design processes in cooperative scenario building workshops are evaluated, regarding how the users and producers were able to contribute. It provides implications and lessons learned for the workshop phase model. A discourse analysis also reveals important facilitator skills and how participants relied on genre in the design process.
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| 50. |
- Löfgren, Björn, et al.
(författare)
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The fidelity of a real time forest machine simulator
- 2007
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Ingår i: Fall Simulation Interoperability Workshop 2007. - 9781622761449 ; , s. 377-398
-
Konferensbidrag (refereegranskat)abstract
- It is essential to reduce the mental and physical stress on forest machine operators. The operator in a harvester cuts down one tree each 47 second, makes 12 decisions per tree and uses on average 24 functions per tree. In Sweden, we are using the Cut To Length (CTL) method, which means that the tree is cut in pieces out in the stand. This is done 1000 times a day. The solutions that come into our mind, to help the operators, are full or semi automation and other ways to improve the Human Machine Interaction (HMI). It is not practical or cost effective to initially develop automation or HMI ideas on real machines. Instead, a better solution is to use simulators. Normally, the existing forest machine simulators are used in teaching future forest machine operators. In our case, we use the simulator as a research tool. To rely on the result coming from tests with the simulator we performed a fidelity test. We conducted a time study, where a harvester operator have cut down approximately 500 trees and we have also measured data from the stand such as tree diameter, height, position, height to first live branch and tree type. We have also measured the terrain. The same stand and terrain data was implemented into the simulator and the same operator performed the same work again. The results demonstrated that there is a good fidelity between a real forest machine and the simulator. The time difference between the reality and the simulator is just ± 5 % for different work operations. Qualitatively, the results were on par. Several aspects on simulator fidelity will be discussed in the paper.
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