| 1. |
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| 2. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 3. |
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| 4. |
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| 5. |
- Olalde, I., et al.
(författare)
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The Beaker phenomenon and the genomic transformation of northwest Europe
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 555:7695, s. 190-196
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Tidskriftsartikel (refereegranskat)abstract
- From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain's gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries.
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| 6. |
- Tagliente, G., et al.
(författare)
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The n_TOF facility at CERN
- 2024
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Ingår i: 16<sup>th</sup> Varenna Conference on Nuclear Reaction Mechanisms (NRM2023). - : EDP Sciences. - 9782759891245
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Konferensbidrag (refereegranskat)abstract
- The neutron Time-of-Flight facility (n_TOF) is an innovative facility operative since 2001 at CERN, with three experimental areas. In this paper the n_TOF facility will be described, together with the upgrade of the facility during the Long Shutdown 2 at CERN. The main features of the detectors used for capture fission cross section measurements will be presented with perspectives for the future measurements.
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| 7. |
- Patronis, N., et al.
(författare)
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Status report of the n_TOF facility after the 2nd CERN long shutdown period
- 2023
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Ingår i: EPJ TECHNIQUES AND INSTRUMENTATION. - : Springer Nature. - 2195-7045. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- During the second long shutdown period of the CERN accelerator complex (LS2, 2019-2021), several upgrade activities took place at the n_TOF facility. The most important have been the replacement of the spallation target with a next generation nitrogen-cooled lead target. Additionally, a new experimental area, at a very short distance from the target assembly (the NEAR Station) was established. In this paper, the core commissioning actions of the new installations are described. The improvement in the n_TOF infrastructure was accompanied by several detector development projects. All these upgrade actions are discussed, focusing mostly on the future perspectives of the n_TOF facility. Furthermore, some indicative current and future measurements are briefly reported.
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| 8. |
- Garcia-Benito, R., et al.
(författare)
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CALIFA, the Calar Alto Legacy Integral Field Area survey III. Second public data release
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 576:A135
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the Second Public Data Release (DR2) of the Calar Alto Legacy Integral Field Area (CALIFA) survey. The data for 200 objects are made public, including the 100 galaxies of the First Public Data Release (DR1). Data were obtained with the integral-field spectrograph PMAS /PPak mounted on the 3.5 m telescope at the Calar Alto observatory. Two different spectral setups are available for each galaxy, (i) a low-resolution V500 setup covering the wavelength range 3745-7500 angstrom with a spectral resolution of 6.0 angstrom (FWHM); and (ii) a medium-resolution V1200 setup covering the wavelength range 3650-4840 angstrom with a spectral resolution of 2.3 angstrom (FWHM). The sample covers a redshift range between 0.005 and 0.03, with a wide range of properties in the color-magnitude diagram, stellar mass, ionization conditions, and morphological types. All the cubes in the data release were reduced with the latest pipeline, which includes improved spectrophotometric calibration, spatial registration, and spatial resolution. The spectrophotometric calibration is better than 6% and the median spatial resolution is 2 4. In total, the second data release contains over 1.5 million spectra.
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| 9. |
- Penston, M. V., et al.
(författare)
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The extended narrow line region of NGC 4151. I. Emission line ratios and their implications
- 1990
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 236:1, s. 53-6262
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Tidskriftsartikel (refereegranskat)abstract
- The paper presents the first results from long-slit spectra of the Seyfert galaxy NGC 4151 which give average diagnostic ratios of weak lines in the extended narrow line region (ENLR) of that galaxy and the first direct density measurement in an ENLR. These data confirm that the ENLR is kinematically undisturbed gas in the disc of the galaxy which is illuminated by an ionizing continuum stronger by a factor of 13 than a power law interpolated between observed ultraviolet and X-ray fluxes. Explanations of this apparent excess include a hot thermal continuum, time variations and an anisotropic radiation field. The authors give reasons for favouring anisotropy which might be caused by shadowing by a thick accretion disc or by relativistic beaming. Shadowing by a molecular torus is unlikely, given the absence of an infrared signal from the reradiated flux absorbed by any torus. Anisotropy would have important implications for the bolometric luminosity and nature of active galactic nuclei
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| 10. |
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| 11. |
- Dietrich, M., et al.
(författare)
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Monitoring of active galactic nuclei. IV. The Seyfert 1 galaxy NGC 4593
- 1994
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 284:1, s. 33-4343
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Tidskriftsartikel (refereegranskat)abstract
- Results of a five-month campaign of optical monitoring the Seyfert 1 galaxy NGC 4593 are presented. High resolution Halpha and Hbeta spectra and direct images in the Johnson U, B, V, R and I bands were obtained between January and June 1990. The emission lines and the continuum showed strong variations on time scales of weeks to days. The Halpha line varied by more than 30% within only 5 days. Cross-correlating the light curves of the Balmer lines with that of the optical continuum gives a lag of around 4 days. Therefore, this low luminosity Seyfert galaxy may have one of the smallest broad line regions known so far
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| 12. |
- Stirpe, G. M., et al.
(författare)
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Monitoring of active galactic nuclei. V. The Seyfert 1 galaxy Markarian 279
- 1994
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 285:3, s. 857-867867
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Tidskriftsartikel (refereegranskat)abstract
- For pt. IV see ibid., vol.284, no.1, p.33-43 (1994). Reports on the Lovers of Active Galaxies' (LAG) monitoring of the Seyfert 1 galaxy Markarian 279 from January to June 1990. The source, which was in a very bright state, gradually weakened after the first month of monitoring: the Halpha and Hbeta flux decreased by 20% and 35% respectively, and the continuum under Halpha by 30%. The luminosity-weighted radius of the broad line region (BLR), as derived from the cross-correlation function, is of the order of 10 light days. This result is very uncertain because the features in the light curves are very shallow, but it is unlikely that the radius of the BLR is more than 1 light month. The profile variations of Halpha confirm that the prevailing motions are not radial. The data of the present campaign and those obtained in previous years, when the source was in a much weaker state, show that the red asymmetry of the Balmer lines correlates positively with the broad line flux. This new effect is briefly discussed
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| 13. |
- Wanders, I., et al.
(författare)
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Spectroscopic monitoring of active galactic nuclei. II. The Seyfert-1 galaxy NGC 3516
- 1993
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 269:1-2, s. 39-5353
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Tidskriftsartikel (refereegranskat)abstract
- The authors present the results of a five month spectroscopic monitoring campaign of the Seyfert-1 galaxy NGC 3516. Using a new calibration method and applying a correction for seeing differences during the various observations they can scale the spectra to each other with a much higher accuracy than hitherto achieved. NGC 3516 shows large amplitude variations on a time scale of several weeks. Asymmetric profile variations occur on the same time scale as the continuum variations. The authors show the presence of a varying dip on the blue wing of the Hbeta profile, which is not present on the Halpha profile, and which corresponds to the absorption features previously seen in the UV emission lines of NGC 3516. From cross-correlation analysis they find a time lag of 14plusmn2 days for the Halpha and 7plusmn3 days for the Hbeta emission-line response to continuum variations
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| 14. |
- Janssen, O., et al.
(författare)
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Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube
- 2020
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Ingår i: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:3, s. 461-471
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The ROADMAP project aimed to provide an integrated overview of European real-world data on Alzheimer's disease (AD) across the disease spectrum. Methods: Metadata were identified from data sources in catalogs of European AD projects. Priority outcomes for different stakeholders were identified through systematic literature review, patient and public consultations, and stakeholder surveys. Results: Information about 66 data sources and 13 outcome domains were integrated into a Data Cube. Gap analysis identified cognitive ability, functional ability/independence, behavioral/neuropsychiatric symptoms, treatment, comorbidities, and mortality as the outcomes collected most. Data were most lacking in caregiver-related outcomes. In general, electronic health records covered a broader, less detailed data spectrum than research cohorts. Discussion: This integrated real-world AD data overview provides an intuitive visual model that facilitates initial assessment and identification of gaps in relevant outcomes data to inform future prospective data collection and matching of data sources and outcomes against research protocols.
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| 15. |
- Schweinsberg, Martin, et al.
(författare)
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Same data, different conclusions : Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
- 2021
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Ingår i: Organizational Behavior and Human Decision Processes. - : Elsevier BV. - 0749-5978 .- 1095-9920. ; 165, s. 228-249
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Tidskriftsartikel (refereegranskat)abstract
- In this crowdsourced initiative, independent analysts used the same dataset to test two hypotheses regarding the effects of scientists' gender and professional status on verbosity during group meetings. Not only the analytic approach but also the operationalizations of key variables were left unconstrained and up to individual analysts. For instance, analysts could choose to operationalize status as job title, institutional ranking, citation counts, or some combination. To maximize transparency regarding the process by which analytic choices are made, the analysts used a platform we developed called DataExplained to justify both preferred and rejected analytic paths in real time. Analyses lacking sufficient detail, reproducible code, or with statistical errors were excluded, resulting in 29 analyses in the final sample. Researchers reported radically different analyses and dispersed empirical outcomes, in a number of cases obtaining significant effects in opposite directions for the same research question. A Boba multiverse analysis demonstrates that decisions about how to operationalize variables explain variability in outcomes above and beyond statistical choices (e.g., covariates). Subjective researcher decisions play a critical role in driving the reported empirical results, underscoring the need for open data, systematic robustness checks, and transparency regarding both analytic paths taken and not taken. Implications for orga-nizations and leaders, whose decision making relies in part on scientific findings, consulting reports, and internal analyses by data scientists, are discussed.
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| 16. |
- Titos, G., et al.
(författare)
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Effect of hygroscopic growth on the aerosol light-scattering coefficient : A review of measurements, techniques and error sources
- 2016
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Ingår i: Atmospheric Environment. - : Elsevier BV. - 1352-2310 .- 1873-2844. ; 141, s. 494-507
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Forskningsöversikt (refereegranskat)abstract
- Knowledge of the scattering enhancement factor,.f(RH), is important for an accurate description of direct aerosol radiative forcing. This factor is defined as the ratio between the scattering coefficient at enhanced relative humidity, RH, to a reference (dry) scattering coefficient. Here, we review the different experimental designs used to measure the scattering coefficient at dry and humidified conditions as well as the procedures followed to analyze the measurements. Several empirical parameterizations for the relationship between f(RH) and RH have been proposed in the literature. These parameterizations have been reviewed and tested using experimental data representative of different hygroscopic growth behavior and a new parameterization is presented. The potential sources of error in f(RH) are discussed. A Monte Carlo method is used to investigate the overall measurement uncertainty, which is found to be around 20-40% for moderately hygroscopic aerosols. The main factors contributing to this uncertainty are the uncertainty in RH measurement, the dry reference state and the nephelometer uncertainty. A literature survey of nephelometry-based f(RH) measurements is presented as a function of aerosol type. In general, the highest f(RH) values were measured in clean marine environments, with pollution having a major influence on f(RH). Dust aerosol tended to have the lowest reported hygroscopicity of any of the aerosol types studied. Major open questions and suggestions for future research priorities are outlined.
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| 17. |
- Harko, T, et al.
(författare)
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Novel couplings between nonmetricity and matter
- 2018
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Ingår i: 15th Marcel Grossmann Meeting on Recent Developments in Theoretical and Experimental General Relativity, Astrophysics, and Relativistic Field Theories, MG 2018. - : World Scientific Publishing Co. Pte. Ltd..
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Konferensbidrag (refereegranskat)abstract
- We present a novel theory of gravity, namely, an extension of symmetric teleparallel gravity. This is done by introducing a new class of theories where the nonmetricity Q is coupled nonminimally to the matter Lagrangian. This nonminimal coupling entails the nonconservation of the energy-momentum tensor, and consequently the appearance of an extra force. We also present several cosmological applications.
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| 18. |
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