| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Norell Bergendahl, Margareta, et al.
(författare)
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Så skapar du det innovativa företaget
- 2008
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Ingår i: Innovationsförmåga. - Stockholm : PIEp. - 9789197785204 ; , s. 18-39
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
- Olsson, Annika, et al.
(författare)
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Ett inspirerande år
- 2008
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Ingår i: Innovationsförmåga. - 9789197785204 ; , s. 6-8
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
- Ambrosi, Aurelie, et al.
(författare)
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Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
- 2012
-
Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 71:3, s. 334-340
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. less thanbrgreater than less thanbrgreater thanMethods The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. less thanbrgreater than less thanbrgreater thanResults There was a recurrence rate of 12.1% in Ro/La-positive women, and no recurrence in Ro/La-negative women. Fetal gender and parity did not influence the development of heart block in either group. Maternal age in Ro/La-positive pregnancies with a child affected by heart block was, however, significantly higher than in pregnancies resulting in babies without heart block (pandlt;0.05). Seasonal timing of pregnancy influenced the outcome. Gestational susceptibility weeks 18-24 occurring during January-March correlated with a higher proportion of children with heart block and lower vitamin D levels during the same period in a representative sample of Swedish women and a corresponding higher proportion of children with heart block born in the summer (pandlt;0.02). Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. less thanbrgreater than less thanbrgreater thanConclusion This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. These observations may be useful for counselling when pregnancy is considered.
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| 5. |
- Anderson, Helén, et al.
(författare)
-
Skapa kundnärvaro i innovationsprocessen
- 2008
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Ingår i: Innovationsförmåga. - Malmö : Holmbergs i Malmö AB. - 9789197785204 ; , s. 40-59
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Bokkapitel (populärvet., debatt m.m.)
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| 6. |
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| 7. |
- Bergström, Annika, et al.
(författare)
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Hormonal concentrations in bitches with primary uterine inertia
- 2010
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Ingår i: Theriogenology. - : Elsevier BV. - 0093-691X .- 1879-3231. ; 73, s. 1068-1075
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Tidskriftsartikel (refereegranskat)abstract
- Normal labor is accompanied by sequential changes in blood concentrations of prostaglandin F2 alpha (measured as 15-ketodihydro-PGF2 alpha = PGFM). progesterone, estradiol, oxytocin, vasopressin, and of elevated cortisol levels The aim of this study was to investigate hormone concentrations in dogs diagnosed with primary uterine inertia before and during treatment by cesarian section. The hypothesis was the dogs would have abnormally low plasma concentrations in one or several of the hormones involved in parturition The study comprised seven bitches with total primary uterine inertia (dystocia group) treated with cesarian section and SIX healthy bitches (control group) subjected to planned cesarean section Blood samples were taken before anesthesia, before surgery started, on delivery of the first puppy and on delivery of the last puppy The progesterone PGFM ratio in plasma was higher in the dystocia group than in the control group. but the serum estradiol concentration did not differ between groups The plasma concentrations of oxytocin and vasopressin increased in both groups when the first puppies were delivered, but both hormones were more elevated in the control group than in the dystocia group on delivery of the last puppies The plasma cortisol concentration increased to the same level in both groups In conclusion, the ratio between progesterone and PGFM was higher and the oxytocin and vasopressin concentrations lower in the dystocia clogs than in the control dogs The findings indicate that these hormones are involved in the pathophysiology of total primary uterine inertia in bitches (C) 2010 Elsevier Inc. All rights reserved
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| 8. |
- Engel, C., et al.
(författare)
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Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
- 2010
-
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 19:11, s. 2859-2868
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Tidskriftsartikel (refereegranskat)abstract
- Background: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the general population.Methods: To evaluate whether the CASP8 D302H (CASP10 V410I) polymorphisms modify breast or ovarian cancer risk in BRCA1 and BRCA2 mutation carriers, we analyzed 7,353 (7,227) subjects of white European origin provided by 19 (18) study groups that participate in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A weighted cohort approach was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; Ptrend = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; Ptrend = 0.004) for BRCA1 but not for BRCA2 mutation carriers. The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers.Conclusions: CASP8 D302H decreases breast and ovarian cancer risk for BRCA1 mutation carriers but not for BRCA2 mutation carriers.Impact: The combined application of these and other recently identified genetic riskmodifiers could in the future allow better individual risk calculation and could aid in the individualized counseling and decision making with respect to preventive options in BRCA1 mutation carriers.
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| 9. |
- Harju, Anne
(creator_code:cre_t, creator_code:res_t)
-
Forskarnas galleri #3 : Space & Place: forskning om social hållbarhet i Malmö
- 2017
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Konstnärligt arbeteabstract
- I Malmö bor cirka 330 000 människor. Hälften av invånarna i Malmö är under 35 år och en femtedel är under 18 år. I utställningen Space & Place kan du ta del av hur två forskargrupper undersöker barns och ungas relation till några av stadens rum. Utställningen belyser metoder i forskningsprocessen.Projekten utgår från barns och ungas upplevelser av sin närmiljö. Forskningen är exempel på hur Malmö högskola bidrar till ett socialt hållbart Malmö.
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| 10. |
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| 11. |
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Litteraturens historia i Sverige
- 2009
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Den femte reviderade upplagan av Litteraturens historia i Sverige (red. Olsson & Algulin mfl) tar litteraturen in i 2000-talet, och läsaren möter bland mycket annat den nya arbetarlitteraturen, chick lit och den svenska deckarboomen. Litterära ikoner som Heliga Birgitta, Selma Lagerlöf och August Strindberg har fått sällskap av samtida författare som Jonas Hassen Khemiri, Henning Mankell och Sara Stridsberg
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| 12. |
-
Litteraturens historia i Sverige
- 2013. - 7
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Litteraturens historia i Sverige ges numera ut av Studentlitteratur AB. Denna sjätte upplaga innehåller dock inga förändringar av innehållet jämfört med den femte upplagan. Litteraturens historia i Sverige är en välskriven och inspirerande handbok med skönlitteraturen i centrum. Inom dess pärmar ryms grundläggande fakta och övergripande perspektiv om texter och författare, från Rökstenen och fram till våra dagar. Den femte reviderade upplagan tar litteraturen in i 2000-talet, och läsaren möter bland mycket annat den nya arbetarlitteraturen, chick lit och den svenska deckarboomen. Litterära ikoner som Heliga Birgitta, Selma Lagerlöf och August Strindberg har fått sällskap av samtida författare som Jonas Hassen Khemiri, Henning Mankell och Sara Stridsberg.De tidigare upplagorna av Litteraturens historia i Sverige och Litteraturens historia i världen mottogs med uppskattande recensioner, och båda böckerna används i undervisningen vid universitet och högskolor. Ny layout och nytt bildmaterial i fyrfärg gör denna upplaga än mer tilltalande och läsarvänlig. Litteraturens historia i Sverige är kort sagt en bok för alla som vill orientera sig i nära tusen år av svensk litteraturhistoria. I denna upplaga har Bernt Olssons och Ingemar Algulins texter kompletterats med nyskrivna texter av Anna Williams, Åsa Arping, Annika Olsson, Boel Westin och Annelie Bränström Öhman, litteraturvetare verksamma vid olika universitet i landet.
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| 13. |
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| 14. |
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| 15. |
- Olsson, Bob, 1969, et al.
(författare)
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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis.
- 2016
-
Ingår i: The Lancet. Neurology. - 1474-4465. ; 15:7, s. 673-684
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (Aβ42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- Wallin, Anders, 1950, et al.
(författare)
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Alzheimer's disease-subcortical vascular disease spectrum in a hospital-based setting: overview of results from the Gothenburg MCI and dementia studies.
- 2016
-
Ingår i: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016. ; 36:1, s. 95-113
-
Forskningsöversikt (refereegranskat)abstract
- The ability to discriminate between Alzheimer's disease (AD), subcortical vascular disease, and other cognitive disorders is crucial for diagnostic purposes and clinical trial outcomes. Patients with primarily subcortical vascular disease are unlikely to benefit from treatments targeting the AD pathogenic mechanisms and vice versa. The Gothenburg mild cognitive impairment (MCI) and dementia studies are prospective, observational, single-center cohort studies suitable for both cross-sectional and longitudinal analysis that outline the cognitive profiles and biomarker characteristics of patients with AD, subcortical vascular disease, and other cognitive disorders. The studies, the first of which started in 1987, comprise inpatients with manifest dementia and patients seeking care for cognitive disorders at an outpatient memory clinic. This article gives an overview of the major published papers (neuropsychological, imaging/physiology, and neurochemical) of the studies including the ongoing Gothenburg MCI study. The main findings suggest that subcortical vascular disease with or without dementia exhibit a characteristic neuropsychological pattern of mental slowness and executive dysfunction and neurochemical deviations typical of white matter changes and disturbed blood-brain barrier function. Our findings may contribute to better healthcare for this underrecognized group of patients. The Gothenburg MCI study has also published papers on multimodal prediction of dementia, and cognitive reserve.Journal of Cerebral Blood Flow & Metabolism advance online publication, 29 July 2015; doi:10.1038/jcbfm.2015.148.
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| 20. |
- Wallin, Anders, 1950, et al.
(författare)
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The Gothenburg MCI study: design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up.
- 2016
-
Ingår i: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016. ; 36:1, s. 114-131
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Tidskriftsartikel (refereegranskat)abstract
- There is a need for increased nosological knowledge to enable rational trials in Alzheimer's disease (AD) and related disorders. The ongoing Gothenburg mild cognitive impairment (MCI) study is an attempt to conduct longitudinal in-depth phenotyping of patients with different forms and degrees of cognitive impairment using neuropsychological, neuroimaging, and neurochemical tools. Particular attention is paid to the interplay between AD and subcortical vascular disease, the latter representing a disease entity that may cause or contribute to cognitive impairment with an effect size that may be comparable to AD. Of 664 patients enrolled between 1999 and 2013, 195 were diagnosed with subjective cognitive impairment (SCI), 274 with mild cognitive impairment (MCI), and 195 with dementia, at baseline. Of the 195 (29%) patients with dementia at baseline, 81 (42%) had AD, 27 (14%) SVD, 41 (21%) mixed type dementia (=AD+SVD=MixD), and 46 (23%) other etiologies. After 6 years, 292 SCI/MCI patients were eligible for follow-up. Of these 292, 69 (24%) had converted to dementia (29 (42%) AD, 16 (23%) SVD, 15 (22%) MixD, 9 (13%) other etiologies). The study has shown that it is possible to identify not only AD but also incipient and manifest MixD/SVD in a memory clinic setting. These conditions should be taken into account in clinical trials.Journal of Cerebral Blood Flow & Metabolism advance online publication, 15 July 2015; doi:10.1038/jcbfm.2015.147.
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| 21. |
- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 22. |
- Albers, Eva, 1966, et al.
(författare)
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Comparison of industrial xylose fermentation with yeast performed at different process scale
- 2012
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Ingår i: 13th International Congress on Yeasts, ICY 2012, August 26-30, Madison, USA.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Second generation of bioethanol production with yeast from lignocellulosic material may contribute to a sustainable production of energy. However, the commercialization of cellulose-to-ethanol remains challenging due to various limitations in process technology and microbial physiology. Despite that the technical progress lately has come far, lignocellulose bioethanol production is still not well established in full production scale. Production scale demands large financial investments and to minimize the risk knowledge about cellular performance of the yeast as response to conditions of large scale is needed. Large scale may impose specific conditions that normally are not present in smaller scale. Such conditions are then needed to be identified and mimicked in smaller scale to obtain crucial scaling-up data. In this project, we wanted to establish scalable cultivation processes and compare the performance at different scales. Experiments were performed at three process scales: lab (1.5 l), process development unit (15 l) and demonstration (10 m3) scales, with an industrial recombinant xylose fermenting Saccharomyces cerevisiae strain and corn cob, bagasse, and spruce lignocellulosic material. It was found that separate fermentation and SSF experiments could be reproducible at all scales. An ethanol level could be obtained above 4 % which is the threshold for feasible down-stream processing. Demonstration scale experiments on xylose-rich liquid of pre-treated corn cobs resulted in a 90% conversion of xylose to ethanol and on the slurry in SSF cultivation an ethanol yield of 0.44 g/g xylose was obtained.
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| 23. |
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| 24. |
- Alkharaan, Hassan, et al.
(författare)
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Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19 : A Complementary Approach to Population Surveys
- 2021
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 224:3, s. 407-414
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking. Methods. Using a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3). Results. Salivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments. Conclusions. Unlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.
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| 25. |
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| 26. |
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| 27. |
- Andersén, Mikael, 1985-, et al.
(författare)
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“It’s about how you take in things with your brain” - young people’s perspectives on mental health and help seeking : an interview study
- 2024
-
Ingår i: BMC Public Health. - : BioMed Central (BMC). - 1471-2458. ; 24:1
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Poor mental health in young people has become a growing problem globally over the past decades. However, young people have also been shown to underutilize available healthcare resources. The World Health Organisation (WHO) has formulated guidelines for youth-friendly health services (YFHSs) to increase youth participation in healthcare. Still, little is known about how young people using these services perceive mental health, indicating a knowledge gap concerning the subjective evaluation of their mental health.Aim: To investigate how young people visiting youth health clinics (YHC) perceive the concept of mental health and factors they view as central to maintaining mental health.Methods: In total 21 interviews were carried out, 16 in 2018, and 5 in 2023 to assure no changes in findings after the COVID-19 pandemic. Subjects were recruited during visits to youth health clinics (YHCs) in mid-Sweden and were aged 15–23 years. Recruitment strived to achieve heterogeneity in the sample concerning gender, sexual orientation, gender identity and age. Interviews were transcribed and analysed using qualitative content analysis.Findings: Findings of the analysis revealed two themes, “Mental health is helped and hindered by the surroundings” and “Mental health is difficult to understand and difficult to achieve”. The participants described their health as highly dependent on their social surroundings, and that these are important to maintaining health but may also affect health negatively. They described mixed experiences of the health care services and mentioned prerequisites for seeking care for mental health problems such as accessibility and respect for their integrity, including the right to turn down offered treatment. The informants also viewed mental health as an ongoing undertaking that one must work for, and that it is sometimes difficult to know what constitutes mental health. They also expressed a need from healthcare services to enquire about their health, and to show an active interest in how they are doing.Conclusions: Findings underline the need of young people’s individual needs to be met in the healthcare system and their vulnerability to their social surroundings. Health status assessments in young people should consider social and individual factors to fully capture mental health.
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| 28. |
- Andersson, Gerd, et al.
(författare)
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Classifying Mobile Services
- 2004. - 1
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A categorization of telecommunications services is presented, as a deliverable in a project commissioned by TeliaSonera.
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| 29. |
- Andersson, Staffan, et al.
(författare)
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Effect of storage time and temperature on stability of bioactive compounds in aseptically packed beverages prepared from rose hips and sea buckthorn berries
- 2015
-
Ingår i: Agricultural and Food Science. - 1795-1895 .- 1459-6067. ; 24:4, s. 273-288
-
Tidskriftsartikel (refereegranskat)abstract
- Rose hips and sea buckthorn berries contain high amounts of beneficial bioactive compounds. In this study the content and stability of natural vitamins and antioxidants were investigated in two fruit beverages made from rose hip powder, sea buckthorn berry puree and white grape juice concentrate, and wheat germ oil in one of the beverages. Beverages were formulated, pasteurised and filled aseptically in Tetra Brik packages and stored up to 35 days at 4 degrees C or 22 degrees C. Samples were analysed for the content of ascorbic acid, carotenoids, major phenolics, tocochromanols, total phenols and total antioxidant capacity as ferric reducing ability. The largest changes occurred during the first 5 days of storage, thereafter mainly ascorbic acid decreased. In the wheat germ oil supplemented beverage, alpha-tocopherol was more rapidly degraded. Negative correlations between the decrease of some carotenoids and tocochromanols, and the increase of some phenolics, suggest relationships of redox reactions specific to the amount of oil supplemented. From the present study we can conclude that additions of oil to beverages should be carefully selected to avoid oxidations of bioactive compounds. Furthermore, packaging of the beverages should be carried out at higher temperatures and thereafter it should be stored at low temperatures (4 degrees C), which decreased oxidation of all bioactive compounds except ascorbic acid.
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| 30. |
- Antoniou, Antonis C., et al.
(författare)
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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:16, s. 3304-3321
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Tidskriftsartikel (refereegranskat)abstract
- Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
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| 31. |
- Barup, Kerstin, et al.
(författare)
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Multi-disciplinary lidar applications
- 2010
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Ingår i: Laser Applications to Chemical, Security and Environmental Analysis, LACSEA 2010. - 2162-2701. - 9781557528803
-
Konferensbidrag (refereegranskat)abstract
- Lidar is a powerful technique normally associated with atmospheric monitoring. However, lidar techniques, also of the laser-induced fluorescence and laser-induced breakdown spectroscopy varieties, provide many new possibilities in unconventional fields including cultural heritage and ecological applications.
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| 32. |
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| 33. |
- Batingan Paredes, Karla Marie, et al.
(författare)
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Organizational climate for innovation and creativity—a study in Swedish retail organizations
- 2018
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Konferensbidrag (refereegranskat)abstract
- Innovation in retailing is under-investigated in academia and yet highly relevant in practice given the current changes in the retail landscape. Although retailing is often characterised by a dynamic and highly competitive environment, retail organizations are not often considered as “innovative,” at least when compared with manufacturing industries or when using existing innovation frameworks in academic literature. There is a need to consider other ways of looking into retailing’s innovativeness—such as looking into the organizational climate— which may help explain how innovation is enabled in service organizations such as retailers. We applied a mixed-methods approach using an organizational climate survey based on Ekvall’s (1996) work, and semi-structured, one-on-one interviews regarding the creative climate and other aspects of innovation management in the companies. The study shows that despite retail organizations still struggling to incorporate innovation on a strategic level and move beyond incremental developments in their operations, retail organizations score positively on being innovative regarding certain dimensions of the creative climate survey. This indicates that retailers (especially conventional ones) could benefit from challenging current practices and moving towards becoming more active innovators, since the creative climate to a certain extent seems to allow for it. Respondents within the organisations also express a need for better innovation support, whether it is through integrated, formalised structures and processes, or an improvement in the current conditions of the organizational climate. How retailers could enable themselves to become more active innovators—based on what we know that retailers look more towards entrepreneurship and continuous development as a driving force rather than institutionalized innovation practices per se—is a potential avenue for further research.
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| 34. |
- Batingan Paredes, Karla Marie, et al.
(författare)
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Retail Innovation: perceptions. management, and challenges of a systematic approach
- 2018
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Ingår i: The ISPIM Innovation Conference. - Åkersberga.
-
Konferensbidrag (refereegranskat)abstract
- The retail industry is looking for new ways to compete as digitalization and non-traditional actors are changing the game. In an industry where constant improvements are key and studies of innovation management are scarce - this qualitative study of four retail firms addresses how innovation is currently perceived and managed. As a result, we have found that innovation is an uncommon theme and there is no systematic approach to innovation management. Furthermore, despite retailers{\textquoteright} proximity to end users, the customer perspective is surprisingly limited, idea development is present but without clear criteria for selection and prioritization from an innovation point of view. For future research, we point to an interesting avenue for retailers as a “hub” for innovation, given their position in the value chain, acknowledging the need for a more strategic and systematic approach.
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| 35. |
- Beckeman, Märit, et al.
(författare)
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Driving forces for food packaging development in Sweden - a historical perspective
- 2005
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Ingår i: World of Food Science.
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Tidskriftsartikel (refereegranskat)abstract
- Availability of safe, edible food is essential. Food shortage has caused many wars and encouraged people to try to preserve food for a longer time, allowing storage and transport, often in some kind of package/container. The USA showed the way in developing the food sector and already prior to the 2nd World War they had self-service stores filled with packed goods. Europe, however, had to wait to apply the US ideas until after the war. As Sweden did not take part, the country got a head start, although with restricted imports and exports and rationing of some food. When self-service retail and new food products, particularly frozen food, became available in the 1950s, the role of packaging and distribution became important, providing mass-produced food at reasonable prices. The country took the lead in frozen food in Europe and became the origin of some quite successful packaging companies and distribution/equipment suppliers, starting up as local supporting companies to the food sector but then expanding into Europe in order to grow. The purpose of this study is to identify the key drivers in society, in the food industry and elsewhere that have affected the development of food-retail packaging, with Sweden as an example of a lead country in Europe for some years after WW II. The study is qualitative and based on semi-structured interviews with experts in the field. The results clearly indicate that frozen food technology and the introduction of self-service stores at about the same time and mainly later chilled/fresh food are the three developments that are considered to have had the most profound influence on the food sector development. Packages were considered as a consequence of the appearance of frozen or chilled food and self-service stores by the interviewees and not as very important in itself, even though neither frozen/chilled food nor self-service stores would exist without packaging and efficient distribution.
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| 36. |
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| 37. |
- Beckeman, Märit, et al.
(författare)
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The importance of packaging innovations in the Swedish food sector
- 2012
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Ingår i: Nordic Retail Research: Emerging diversity. ; , s. 193-211
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Bokkapitel (refereegranskat)abstract
- Abstract in Undetermined Packaging is of particular importance to retailers, since it can be considered an integral part of the product and the first point of contact with the brand (Rundh 2005). Over 73% of interviewed consumers rely on packaging to aid their purchasing decisions (Wells et al. 2007), and retailers are the ‘gatekeepers’ to the consumers (Dobson et al. 2003) via the retail stores, where the packaging of a product is what meets the eyes of consumers. Young (2008:26) simply states, “The package is the product”, and packaging “combines the ‘4 Ps’ of marketing: the package contains the product, packages convey messages about product attributes to consumers as part of public relations, and often its price, while also carrying promotions”, making it an integral part of the product (Hawkes 2010:297). Hence, innovations in packaging and packaging systems in the food sector are intimately connected with the contained products; success or failure can be due to either or both aspects. And the success rate of food products is low: 80 to 90% of all launched products fail within the first year, in the USA (Rudolph 1995), with similar figures in other countries. This might be due to shortcomings in the methodology to develop (Stewart-Knox & Mitchell 2003) or that the right business model to “capture value from innovations” has not been designed (Teece 2010:183). And “value exists only if the consumer perceives it as such” (Burt 1989:29). Today, many retailers control the supply chain from producers to consumers (Fernie & Sparks 2009), have expanded their range of differentiated private labels (Burt & Sparks 2002) and increasingly compete with manufacturers’ brands, including in Sweden (Beckeman & Olsson 2011). This has resulted in increased demands for more flexible production to meet a greater variety of packaging sizes, products, recipes and delivery on demand, without increasing The importance of packaging innovations in the Swedish food sector 11 194 Chapter 11 the costs, and consequently smaller order sizes and varying designs (Van Donk 2001; Van Donk et al. 2008). The real breakthrough for packaged food in Sweden came with the introduction of frozen food in 1945 and self-service stores in 1947, both of which demanded packaging (Beckeman 2006). These changes initiated efficient supply chains, which together with a value perspective have become a necessity for the different requirements of various food products (Fisher 1997; Gustafsson et al. 2006). Food and beverages range from dry products to liquids, requiring distribution/storage temperatures from ambient, via refrigerated to frozen. Hence, product demands on packaging vary. The broader background to this chapter can be found in a doctoral thesis (Beckeman 2011) based on interviews with retailers, food manufacturers and packaging suppliers active in Sweden. To our knowledge, no similar investigation of the Swedish food sector of today has been carried out. The purpose was to investigate how the three groups of actors view innovations in their own area, their roles and the roles of other actors in the chain; i.e. if there is a gap of opinions about innovations among them. This chapter summarises the results from interviewing packaging suppliers based on the following research questions: • How do innovative Swedish packaging suppliers define innovations, and how do they regard their own role in food innovations? • What is the nature of the collaboration among packaging suppliers and other actors in the supply chain regarding food innovations? ‘Consumer’ is defined as the end consumer of a food product, whereas a ‘customer’ can be a food manufacturer, a retailer or the next link in the packaging supply chain, as packaging suppliers cannot be defined as one homogenous group. They can be material producers, packaging converters, packaging machinery suppliers and other relevant suppliers (Paine 2002), and can work as partners, sub-suppliers and/or competitors with each other, depending on the situation and the demands. In this mixture of packaging suppliers, some are considered more innovative and successful than others, as previously suggested by interviewed retailers (Beckeman & Olsson 2011) and food manufacturers (Beckeman et al., in press) and are the focus of this study. This chapter is organised as follows: it starts by summarising literature on packaging and packaging functions and related to food innovations, continues with methodology, including framework for analysis, which is followed by results and analysis, and ends with conclusions.
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| 38. |
- Beckeman, Märit, et al.
(författare)
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The role of manufacturers in food innovations in Sweden
- 2013
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Ingår i: British Food Journal. - 0007-070X. ; 115:7, s. 953-974
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – The purpose of this paper is to investigate how food manufacturers in Sweden define and view innovations, how they view their role and those of other actors and the interaction/collaboration regarding innovations in the food supply/value chain. Design/methodology/approach – After an exploratory pre-study with 12 participants, a full study of Swedish manufacturers comprised of representatives from 12 food companies was initiated. In total, 21 interviews were carried out. The majority of the respondents had food industry experience. They initially answered structured questions and thereafter open-ended ones. Findings – Few, if any, innovations in the Swedish food sector are considered radical. Many are “invisible” to meet demands for lower cost, shorter orders and sustainability. The food manufacturers seem to develop products in house for consumers and not by working with them or others inside or outside the supply chain; they do not adopt an “open” innovation mindset. There is lack of trust in the chain and limited exchange of information. Some manufacturers pursue horizontal collaboration with other manufacturers abroad. Research limitations/implications – Innovations and strategies are a competitive edge for a company, so the respondents may not have been completely open. Practical implications – Manufacturers and the whole supply chain would benefit from an “open innovation” mindset to organise and work differently and build trust. Originality/value – There is no other published study on innovations and food manufacturers in Sweden. The food sector should embark on collaboration and coopetion and initiate discussions on what can be done to become more innovative.
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| 39. |
- Beckeman, Märit, et al.
(författare)
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The role of packaging suppliers in food innovations in Sweden
- 2010
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Konferensbidrag (refereegranskat)abstract
- This study investigated how selected packaging suppliers viewed innovations in food packaging, their role and the roles of other actors in the chain. Six companies and ten respondents were selected based on suggestions from previous interviews of retailers and food manufacturers. Data collection consisted of responses to specific questions followed by responses to open-ended questions. The results showed that many packaging suppliers are far removed from the end customers/consumers and out of touch with wishes and trends in the market, but that they have been responsible for many innovations in Sweden. This presents an opportunity for supply chain collaboration.
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| 40. |
- Beckeman, Märit, et al.
(författare)
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The role of Swedish retailers in food innovations
- 2011
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Ingår i: International Review of Retail, Distribution and Consumer Research. - 0959-3969. ; 21:1, s. 51-70
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Tidskriftsartikel (refereegranskat)abstract
- Innovations should create value for increasingly individualistic consumers with varying demands and for other stakeholders. Today, retailers have the power in the supply/value chain. This research investigates how Swedish food retailers view innovations, their role and that of customers and suppliers in the development process, and how they see future development. The study is based on open-ended interviews. The results show that Swedish retailers regard food product innovations as something to provide to consumers rather than achieve with consumers. Retailers want more collaboration with packaging suppliers to differentiate. Retailers are successful in establishing their own brands, in becoming brands themselves, and in competing with producer brands. This follows the UK model and may result in fewer alternatives in stores and fewer product- or new technology-based innovations by Swedish producers. Service innovations can still occur for retailers to retain consumer loyalty. Consumers demand more than new products, they want to be excited by the shopping experience. More innovations will require deeper insight about consumers, efforts from the value chain and from outsiders. Collaboration is needed to establish trust among supply chain actors.
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| 41. |
- Berg, Anna-Karin, et al.
(författare)
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Antiviral Treatment of Coxsackie B Virus Infection in Human Pancreatic Islets
- 2007
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Ingår i: Antiviral Research. - : Elsevier BV. - 0166-3542 .- 1872-9096. ; 74:1, s. 65-71
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Tidskriftsartikel (refereegranskat)abstract
- Enterovirus infections of the pancreatic islets are believed to trigger or precipitate the near total destruction of β-cells that constitutes type 1 diabetes (T1D). This study investigated the ability of an anti-picornaviral compound, pleconaril, to block the replication of two β-cell tropic Coxsackie B4 virus (CBV-4) strains in isolated human islets. The two strains, VD2921 and V89 4557, with demonstrated abilities to cause non-lytic persistence or lytic infection, respectively, in islets, represented two different potential mechanisms behind virus-induced T1D. The virus replication in the islets was studied with and without addition of pleconaril. In addition, islet morphology was studied every day. To test the effects of pleconaril and/or DMSO on the β-cells’ insulin secretion, glucose perifusions were performed on treated and untreated islets. Virus titrations showed a clear reduction of the replication of both strains after pleconaril treatment. The VD2921 strain was inhibited to undetectable levels. The V89 4557 strain, however, showed an initial reduction of titers but virus titers then increased despite the addition of a second dose of pleconaril. This incomplete inhibition of viral replication suggested the existence of a resistant subtype within this strain. Pleconaril treatment reduced the β-cells’ insulin secretion in response to glucose stimulation in some experiments and induced slight morphological changes to the islets compared to untreated controls. In summary, pleconaril reduced the replication of the two β-cell tropic CBV-4 strains in human islets. However, genetic differences between these strains influenced the effectiveness of pleconaril treatment. This stresses the importance of using multiple viral strains in antiviral tests.
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| 42. |
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| 43. |
- Bergquist, Annika, et al.
(författare)
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Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
- 2008
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Ingår i: Clinical Gastroenterology and Hepatology. - New York : Elsevier. - 1542-3565 .- 1542-7714. ; 6:8, s. 939-943
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: The importance of genetic factors for the development of primary sclerosing cholangitis (PSC) is incompletely understood. This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC. Methods: Subjects from the national Swedish cohort of PSC patients (n = 678) were matched for date of birth, sex, and region to up to 10 subjects without a diagnosis of PSC (n = 6347). Linkage through general population registers identified first-degree relatives of subjects in both the PSC and comparison cohorts (n = 34,092). Diagnoses among first-degree relatives were identified by using the Inpatient Register. Results: The risk of cholangitis was statistically significantly increased in offspring, siblings, and parents of the PSC patient cohort, compared with relatives of the comparison cohort, with the hazard ratios and 95% confidence intervals, 11.5 (1.6–84.4), 11.1 (3.3–37.8), and 2.3 (0.9–6.1), respectively. The hazard ratios for ulcerative colitis (UC) among first-degree relatives of all PSC patients was 3.3 (2.3–4.9) and for Crohn's disease 1.4 (0.8–2.5). The risk of UC for relatives of PSC patients without IBD was also increased, 7.4 (2.9–18.9). Conclusions: First-degree relatives of patients with PSC run an increased risk of PSC, indicating the importance of genetic factors in the etiology of PSC. First-degree relatives of PSC patients without IBD are also at an increased risk of UC, which might indicate shared genetic susceptibility factors for PSC and UC.
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| 44. |
- Bergquist, Annika, et al.
(författare)
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Perinatal events and the risk of developing primary sclerosing cholangitis
- 2006
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 12:37, s. 6037-6040
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life.METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC.RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life.
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| 45. |
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| 46. |
- Bertoluci, Gwenola, et al.
(författare)
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Exploring the environmental impacts of olive packaging solutions for the European food market
- 2014
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 64:1, s. 234-243
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Tidskriftsartikel (refereegranskat)abstract
- Reduction of packaging waste has been a European target for more than 40 years. However, packaging is indispensable for protecting what it carries. In this study, an analysis of the European regulations on packaging and of their resulting effect on recycling performance was performed by means of a literature survey and the national results published in the European Database, Eurostat. Based on these data, two series of five Life Cycle Assessments (corresponding to the national situation of five European countries: France, Germany, Italy, Spain, Sweden) were conducted on three olive packaging solutions: doypacks, glass jars and steel cans. The results highlight the influence of national household waste collection rates and selected technologies for waste treatment (recycling and incineration) on the environmental performance of packaging design. A qualitative analysis of user expectations by means of a questionnaire demonstrates that the environmentally better solution (doypack) was not aligned with user expectations. The loss of food introduced by the better packaging solution is also a reason to question its value. The authors conclude that it is important to increase waste collection rates and recycling in order to actually improve packaging sustainability. They also conclude that eco-design of packaging cannot be considered only in terms of the materials employed: the contribution of the consumers’ behavior is also a determinant criterion in the design of food packaging.
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| 47. |
- Bill, Susanna, et al.
(författare)
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Rethinking User Involvement in the Front End of Healthcare Innovation
- 2011
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Konferensbidrag (refereegranskat)abstract
- The purpose of this paper is to share insights from an empirical study within the Swedish healthcare system, based on a case study of the largest business unit of a Swedish medical technology company and its key customer segment. The study involving a Swedish medical technology company and three Swedish hospitals indicates need to move away from an archetypical, largely homogeneous view of the user, towards a more flexible, heterogeneous user perspective. Following from that insight the paper outlines a preliminary model aimed at improving the conditions of the firm for user involvement in the front end of healthcare innovation. In the proposed model, different users are brought to the foreground in different parts of the front-end innovation process. The research performed aimed at putting the business unit in a more beneficial position to involve users in the front end of innovation by increasing their understanding of a) which user types they actually have access to, b) which roles that different user types may take in the various stages of the innovation front-end.
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| 48. |
- Bindler, Annika, et al.
(författare)
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Academic literacies and PhD education? : Aspirations, implementation, and implications from a doctoral workshop series
- 2017
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Ingår i: Universitetspedagogiska konferensen 2017. - Umeå : Universitetspedagogik och lärandestöd (UPL), Umeå universitet. ; , s. 54-55
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This presentation reports on the process of developing and implementing a workshop series for PhD students at the Academic Resource Centre, Umeå University, launched for the first time during the spring term 2017. Adopting an academic literacies model (Lea & Street, 1998, 2006) as the framework for the course's underlying principles, its design and instruction, we propose that literacy in a university setting and especially at doctoral level can be understood not only as the individual, transferable cognitive skills of writing and reading. Rather, it is an interrelated, dynamic, and situated set of knowledge, skills, and personal attributes that support PhD students to acculturate themselves into their disciplinary discourses, as well as the academic community and wider social contexts.Lea and Street's (2006) academic literacies model draws from both the surface features of language form (the study skills model) and students' acculturation into a disciplinary and subject area community (the academic socialisation model). However, the academic literacies model moves beyond the academic socialisation model by considering social processes (such as power, identity, and authority). This model has been used in different higher education contexts, enabling the conceptualising and reconceptualising of the knowledge students should learn and do with regards to academic writing and reading (e.g. Wingate, 2012; Castanheira, Street, & Carvalho, 2015; Guzmán-Simón, García-Jiménez, & López-Cobo, 2017).In the particular setting of Umeå University, the Academic Resource Centre, University Library is the unit who provides academic support to students at all levels, including PhD students. From our experience as academic tutors, academic librarians and researchers working with the University's doctoral students, we were able to identify their need for support not only with thesis texts written in English but also a range of capabilities such as article reading, research communicating, information searching, and publishing. These needs have also been expressed by PhD students themselves. As a result, the workshop series "Write here, Write now" was developed and implemented by the Academic Resource Centre during March – May 2017. Informed by the academic literacies model, a number of factors were considered as we approached writing. Besides the focus of helping students to improve their academic English, we wished to highlight that writing is a process which involves a myriad of competence, and it is a social practice rather than merely an individual cognitive skill. Above all, we aspired to develop a course that aligns with the national goals for Swedish PhD education which are set beyond the final thesis; the aim is to educate a critical, autonomous, creative, and responsible PhD researcher (Swedish Higher Education Ordinance, Annex 2, Qualifications Ordinance). The course should also be designed following the fundamental principles of teaching and learning in higher education that promote critical thinking, active learning, learner autonomy, and collaborative learning.In our presentation, we will show how these aspirations have helped us with our attempts at defining "literacy" in PhD education at Umeå University as lying at the intersection of English language, research competence, and Information literacy. Examples of how we incorporated the intended contents and guiding principles in our pedagogical practices will be provided. Reflections on our roles as instructors and further implications regarding policy on PhD education in the Swedish context will also be discussed.
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| 49. |
- Bindler, Annika, et al.
(författare)
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No Writing Center is an Island : A Swedish Writing Center and its University Library Work Together
- 2016
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Writing center tutors and librarians share in the goal of helping students with the recursive processes of writing and researching. Nevertheless, few writing centers that are located in university libraries work collaboratively, but rather simply share a location.Research from the US shows that collaboration can take different forms, and while some of these may be readily transferable to European university systems, some will be challenging to implement. Also, this research tends to originate from librarians rather than writing consultants (Ferer, 2012).Umea University is unusual in that it works collaboratively. Drawing on our experience, we will provide a Swedish university's perspective based on the collaboration between its Writing Centre and University Library. We explain how we work together to match students' writing and researching needs, the challenges in collaborating, and what future additional collaborations are possible. Finally, we raise the question, what more can we do to develop and maintain our collaboration?Discussing best practices can provide valuable information to better meet the new generation of students. Research, thinking and writing go hand in hand. Rather than compartmentalizing these processes, writing tutors and librarians can work together with students to help them navigate these intricately linked processes. Collecting this expertise into one location allows students more comprehensive support and convenient access: "one-stop shopping" (Cooke & Bledsoe, 2008).Writing centers and libraries can have an influence in the current reformation of higher education and should contribute to the discussion by promoting their strengths and sharing their respective knowledge (Elmborg, 2005). We hope to contribute to the conversation through our presentation.
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| 50. |
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