| 1. |
- Bäck, Sven, et al.
(författare)
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Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements
- 1999
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 1361-6560 .- 0031-9155. ; 44:8, s. 1983-1996
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Tidskriftsartikel (refereegranskat)abstract
- Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from that obtained using photon beams. However, on normalization at the entrance, the relative 1/T1 at the Bragg peak was 15-20% lower than the corresponding ionization chamber data for the monoenergetic proton beam. Better agreement was found for the modulated beam, but with significant differences close to the distal edge of the 1/T1 distribution. The change in sensitivity with depth was explained by means of a linear energy transfer dependence. This property was further studied using Monte Carlo methods.
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| 2. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 3. |
- Olsson, Anki, Medicine doktor, et al.
(författare)
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Activated platelet aggregation is transiently impaired also by a reduced dose of protamine
- 2019
-
Ingår i: Scandinavian Cardiovascular Journal. - : TAYLOR & FRANCIS LTD. - 1401-7431 .- 1651-2006. ; 53:6, s. 355-360
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Protamine reduces platelet aggregation after cardiopulmonary bypass (CPB). We studied the inhibitory effect of a reduced protamine dose, the duration of impaired platelet function and the possible correlation to postoperative bleeding. Design: Platelet function was assessed by impedance aggregometry in 30 patients undergoing cardiac surgery with CPB at baseline, before protamine administration, after 70% and 100% of the calculated protamine dose, after 20 minutes and at arrival to the intensive care unit. Adenosine diphosphate (ADP), thrombin receptor activating peptide-6 (TRAP), arachidonic acid (AA) and collagen (COL) were used as activators. Blood loss was measured during operation and three hours after surgery. Results are presented as median (25th-75th percentile). Results: Platelet aggregation decreased markedly after the initial dose of protamine (70%) with all activators; ADP 89 (71-110) to 54 (35-78), TRAP 143 (116-167) to 109 (77-136), both p < .01; AA 25 (16-49) to 17 (12-24) and COL 92 (47-103) to 60 (38-81) U, both p < .05. No further decrease was seen after 100% protamine. The effect was transient and after twenty minutes platelet aggregation had started to recover; ADP 76 (54-106), TRAP 138 (95-158), AA 20 (10-35), COL 70 (51-93) U. Blood loss during operation correlated to aggregometry measured at baseline and after protaminization. Conclusions: Protamine after CPB induces a marked decrease in platelet aggregation already at a protamine-heparin ratio of 0.7:1. The impairment seems to be transient and recovery had started after 20 minutes.
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| 4. |
- Sjöblom, Ted, et al.
(författare)
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REEDS : Reference data and algorithms for research and development of smart ships
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish Transport Administration Research and Innovation fund for Maritime research funded the project "Reference data and algorithms to support research and development of smart ships". The project goes by the working name, and is communicated as, Reeds. It responds to a synthesis of a number of different needs identified in previous projects and studies. The background to the project is that in recent years the focus has been on developing algorithms to interpret and act on the physical environment around different types of craft. In order to be able to develop and evaluate these algorithms, it has become clear that open datasets and a fair benchmarking platform are required that allow various developers in industries and researchers to evaluate algorithms. In the road vehicle sector, Kitti, as of 2013, is the largest dataset used as a reference dataset. The dataset in this project contains sensor data from several data collection occasions within a maritime context, from high-precision sensors such as cameras, radar, lidar, and IMU. For marine applications, there has been no similar dataset with anywhere near the same amount of data and time synchronisation between sensors. The reference data and reference algorithms were available periodically during the project through an online service where researchers and developers could upload their algorithms to use the dataset.In addition to the dataset itself, Reeds adds additional strengths compared to other reference datasets:- New approach to comparing algorithms fairly, where new algorithms are always compared on a centralised hardware in a cloud service and re-evaluated when new data is added, i.e. an unbiased algorithm evaluation service.- Method that combines NTP and PTP time protocols for synchronisation between the sensors with microsecond accuracy- More types and more modern sensors that can be used at a higher level of abstraction and can thus be applied in more areas.- Sensor fusion of both onboard and land-side sensors- Identify areas of application for navigation and surveillance on land based on the algorithms developed during the project and the use of new sensor types not established in shipping.- The project built up a maritime reference data set that enables the creation of a digital description for the ship's surrounding environment and developed reference algorithms to demonstrate new navigation and monitoring methodology in the area of "enhanced navigation"."Enhanced navigation" is defined under the project as the use of new technology based on developments in digitisation and autonomous functions, where new navigation methods use sensors both on board and ashore to increase maritime safety and robustness. The project has built a web-based user interface referred to in the report as "Crowsnest" that handles these new sensors and visualises this data in a familiar interface similar to an overlay in ECDIS that is openly available for the public to build on. Which was used for the evaluation and concept development of new user interfaces based on feedback from pilots and VTS operators.By providing reference datasets and reference algorithms with demonstrations, researchers and companies now have the opportunity to develop algorithms for the intelligent and autonomous ships of the future.
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| 5. |
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| 6. |
- Uhlén, Mathias, et al.
(författare)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Tidskriftsartikel (refereegranskat)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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| 7. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 8. |
- Abboud, Amina, et al.
(författare)
-
Årsbok 2018 : Socialhögskolan, Lunds universitet
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Socialhögskolans årsbok ger en liten inblick i vad vi gör och vi hoppas att den bidrar till att presentera utsnitt från vår verksamhet på ett trevligt och samlat sätt. Årsboken som är Socialhögskolans tredje uppmärksammar inte bara det som skett på Socialhögskolan under 2018. Den uppmärksammar även att 2018 var året då svensk äldreomsorg fyllde 100 år. Årsbokens gästredaktör Per Gunnar Edebalk inleder därför bokens forskningsavsnitt med att i år skriva om just hundraåringens historia. Det är inledningen på ett avsnitt där flera forskare vid Socialhögskolan bjuder på bidrag som lyfter fram aspekter av äldreomsorg och åldrande.Håkan Jönson och Tove Harnett resonerar om de begrepp som omgärdar äldreomsorgens möten och organisering sett i ett socialt arbetets perspektiv. De två har även skrivit en artikel om huruvida behov ska ses annorlunda mellan grupper bara för att man passerat en viss ålder.Däremellan presenteras en text av Erika Werner som låter oss möta frågor kring en sviken generation, här genom ett möte med Agnes, som hamnade mitt i skarven när pensionssystemet reformerades. Elisabeth Carlstedt presenterar en text om hur äldreomsorgens särskilda boenden arbetar i relation till Socialtjänstlagens direktiv om meningsfullhet och värdighet, och hur svårt det är. Lars Harrysson presenterar därefter ett avsnitt om två forskningsprojekt som han och Erika Werner gjort där fokus har legat dels på pensioner för personer i ekonomiskt utsatta grupper, speciellt med migrantbakgrund, dels om hur tro och äldreomsorg samspelar, eller inte. Äldreomsorgsavsnittet avslutas sedan med en intervju som Patrik Hekkala gjort med Peter Andersson som startade kursen socialt arbete med äldre och med Tove Harnett som tagit över och fortsatt utvecklingsarbetet till dags datum.Årsboken avslutas sedan med fyra texter. En av Amina Abboud, snart färdig socionom, som skriver om sina erfarenheter av och i uppsatsskrivandet. Sedan en där vi får möta Carina Olsson som arbetat hos oss länge, men som faktiskt arbetat vid universitetet i 40 år 2018. Emelie Dahlström, Joakim Grina och Jan Abrahamsson ger sedan en bakgrundsteckning till en hos Socialhögskolan verksam social accelerator, SoPact. Som avrundning finner du sedan lite mer information om vår verksamhet här vid Socialhögskolan.
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| 9. |
- Abdallah, Jalal, et al.
(författare)
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Study of energy response and resolution of the ATLAS Tile Calorimeter to hadrons of energies from 16 to 30 GeV
- 2021
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:6
-
Tidskriftsartikel (refereegranskat)abstract
- Three spare modules of the ATLAS Tile Calorimeter were exposed to test beams from the Super Proton Synchrotron accelerator at CERN in 2017. The detector’s measurements of the energy response and resolution to positive pions and kaons, and protons with energies ranging from 16 to 30 GeV are reported. The results have uncertainties of a few percent. They were compared to the predictions of the Geant4-based simulation program used in ATLAS to estimate the response of the detector to proton-proton events at the Large Hadron Collider. The determinations obtained using experimental and simulated data agree within the uncertainties.
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| 10. |
- Ahlberg, Erik, et al.
(författare)
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"Vi klimatforskare stödjer Greta och skolungdomarna"
- 2019
-
Ingår i: Dagens nyheter (DN debatt). - 1101-2447.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
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| 11. |
- Ahlgren, Benjamin, et al.
(författare)
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A simplified model for linear correlation between annual yield and DNI for parabolic trough collectors
- 2018
-
Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 174, s. 295-308
-
Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a simple method for estimating annual thermal performance of parabolic trough collectors (PTCs) based on a linear relation with annual DNI for a certain latitude. A case study with simulations for a novel concentrating solar collector in 316 locations for three operating temperature scenarios worldwide was carried out and showed promising results for the latitudes and continents investigated. For a certain latitude and mean operating temperature, the annual yield of a PTC was found to be linearly proportional to yearly DNI. The proposed method will serve as a simplified alternative to the steady-state and quasi-dynamic methods already used. Estimating performance based on yearly DNI can be used by design engineers to do quick preliminary planning of solar plants. Customers can also use this method to evaluate existing solar collector installations. A TRNSYS/TRNSED tool that uses a steady-state model has been developed to carry out the simulations and it has been validated against a PTC array at Technical University of Denmark (DTU). The results show that the simplified method can give reliable estimates of long-term performance of parabolic trough collectors.
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| 12. |
- Akselsson, Roland, et al.
(författare)
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Virtual Reality in Air Traffic Control
- 2000
-
Ingår i: Proceedings of the IEA 2000/HFES 2000 Congress. ; 6, s. 6-275
-
Konferensbidrag (refereegranskat)abstract
- Air traffic control is a highly spatial work. However, there are currently no three-dimensional tools used in the education of air traffic controllers or in the operational work of air traffic control. This paper presents results from some pilot studies aiming to: -Find new techniques for visualization and editing of trajectories in air traffic control. -Investigate how Virtual Reality (VR) can contribute to the air traffic controllers’ understanding of the air space and of certain situations. Two VR models have been developed. In one model a procedure called ‘holding’ is visualized. In the other VR model the different sectors in the air space are shown to make it easier for the air traffic controller to build a mental picture of a sector. In a training package the user can fly around in the sector and see how traffic passes through. These introductory studies indicate the usefulness of new ways to present the third dimension in a variety of air traffic situations. The tools can be used to visualize a three dimensional situation and help the air traffic controller to build a mental model The most obvious application area is in training and education of air traffic controllers but other applications such as an explanation and communication tool in the investigation after an incident are of interest.
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| 13. |
- Al Nimer, Faiez, et al.
(författare)
-
Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination
- 2016
-
Ingår i: Neurology. - 2332-7812. ; 3:1
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: We aimed to examine the regulation of lipocalin-2 (LCN2) in multiple sclerosis (MS) and its potential functional relevance with regard to myelination and neurodegeneration. Methods: We determined LCN2 levels in 3 different studies: (1) in CSF and plasma from a case-control study comparing patients with MS (n = 147) with controls (n = 50) and patients with relapsing-remitting MS (n = 75) with patients with progressive MS (n = 72); (2) in CSF and brain tissue microdialysates from a case series of 7 patients with progressive MS; and (3) in CSF at baseline and 60 weeks after natalizumab treatment in a cohort study of 17 patients with progressive MS. Correlation to neurofilament light, a marker of neuroaxonal injury, was tested. The effect of LCN2 on myelination and neurodegeneration was studied in a rat in vitro neuroglial cell coculture model. Results: Intrathecal production of LCN2 was increased predominantly in patients with progressive MS (p < 0.005 vs relapsing-remitting MS) and displayed a positive correlation to neurofilament light (p = 0.005). Levels of LCN2 in brain microdialysates were severalfold higher than in the CSF, suggesting local production in progressive MS. Treatment with natalizumab in progressive MS reduced LCN2 levels an average of 13% (p < 0.0001). LCN2 was found to inhibit remyelination in a dose-dependent manner in vitro. Conclusions: LCN2 production is predominantly increased in progressive MS. Although this moderate increase does not support the use of LCN2 as a biomarker, the correlation to neurofilament light and the inhibitory effect on remyelination suggest that LCN2 might contribute to neurodegeneration through myelination-dependent pathways.
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| 14. |
- Albers, Eva, 1966, et al.
(författare)
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Influence of preservation methods on biochemical composition and downstream processing of cultivated Saccharina latissima biomass
- 2021
-
Ingår i: Algal Research. - : Elsevier BV. - 2211-9264. ; 55
-
Tidskriftsartikel (refereegranskat)abstract
- Saccharina latissima biomass cultivated along the Swedish west coast was subjected to four different scalable preservation methods after harvest; freezing, sun-drying, oven-drying and ensiling. Freeze-drying and freezing at -80 ?C were also included to provide dry and wet references. The effects of the different preservation methods on the composition of Saccharina biomass (on dry weight, DW, basis), and the recovery as well as properties of high-quality protein, alginate and biogas were evaluated. Sun-drying significantly reduced protein, alginate and fatty acid content of the seaweeds and thereby concentrated ash in the biomass compared to the other methods. Protein/amino acids and fatty acids were significantly concentrated in ensiled biomass, while mannitol and laminarin were reduced compared to the other biomasses. Oven-drying and -20 ?C freezing affected the composition the least, with lower ash content and alterations in some specific amino and fatty acids. Sun-drying and ensiling resulted in significantly lower protein solubility at high pH compared to the other biomasses which translated into the lowest total seaweed protein recovery using the pH-shift process. Highest protein yield was obtained with the freeze-dried reference. Ensiling lead to a significant decrease in the molecular weight of alginate, while sun-drying caused a negative effect on alginate by inducing a shift in the guluronic and mannuronic acids composition of alginate. Sun-drying gave the lowest methane yield in the anaerobic digestion experiments while freezing at -80 ?C gave the highest yield, closely followed by freezing at -20 ?C and ensiling. To conclude, preservation methods must be carefully chosen to protect the valuable component in Saccharina latissima, and to achieve an efficient downstream processing ultimately yielding high quality products as part of a seaweed biorefinery.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Axaeus, Jennie, 1974-, et al.
(författare)
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Portar till språk och litteratur : CSL 2007
- 2007
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Språk och litteratur öppnar portar till nya världar. Detta var temat för 2007 års CSL-dag. I denna bok har vi samlat fjorton av bidragen som presenterades på konferensen, skrivna av forskare och studenter vid Karlstads universitet.Håller engelskan på att förstöra svenskan? Är dagens elever sämre på att skriva än ungdomarna var för tjugo år sedan? Skall vi ha en litteraturkanon i skolan - och läser eleverna över huvud taget böcker nu för tiden? Detta är några av de frågor som ställs i artiklarna där svaren kanske kan överraska.Andra artiklar handlar om hur man stimulerar elever till att läsa och skriva, problematiken när det gäller att undervisa i svenska som andraspråk och varför elever väljer - eller inte väljer - att studera något annat främmande språk än engelska. Porten kanske finns där - men den är inte alltid helt lätt att öppna!
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| 19. |
- Balachandramurthi, Arun Ramanathan, 1989-, et al.
(författare)
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Microstructure tailoring in Electron Beam Powder Bed Fusion Additive Manufacturing and its potential consequences
- 2019
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Ingår i: Results in Materials. - : Elsevier. - 2590-048X. ; 1
-
Tidskriftsartikel (refereegranskat)abstract
- Electron Beam Powder Bed Fusion process for Alloy 718 was investigated, in the sense of microstructural evolution with varying process conditions. The existence of a geometric relationship between the melt front and the processing parameters was observed. By understanding and capitalizing on this relationship, it was possible to obtain columnar, equiaxed or bimodal microstructure.
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| 20. |
- Balogh, Joakim, et al.
(författare)
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A SANS contrast variation study of microemulsion droplet growth
- 2007
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Ingår i: The Journal of Physical Chemistry Part B. - : American Chemical Society (ACS). - 1520-5207 .- 1520-6106. ; 111:4, s. 682-689
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Tidskriftsartikel (refereegranskat)abstract
- An extensive small angle neutron scattering study is presented using contrast variation on the growth of nonionic microemulsion droplets as the temperature and thus spontaneous curvature is varied away from the emulsification failure boundary, EFB, toward zero spontaneous curvature. Two ternary systems are compared. They only differ by the chain length of the oil ( decane and hexadecane, respectively). Droplets grow in size as one moves away from the EFB. SANS data from ten different contrasts were fitted simultaneously with a model of polydisperse prolate shaped droplets interacting with an effectively hard sphere potential, and the data set further included three different droplet concentrations and four different temperatures. The model of prolates provided a good description of the data. The prolate axial ratio, obtained from the fits, increased with increasing temperature but showed only a minor variation with the droplet concentration. The two systems with different oils behave quantitatively different. In both systems, however, the droplet growth is only minor, with maximum axial ratios of about 3-4, before a bicontinuous microemulsion is formed.
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| 21. |
- Balogh, Joakim, et al.
(författare)
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Dependence on oil chain-length of the curvature elastic properties of nonionic surfactant films: Droplet growth from spheres to a bicontinuous network
- 2007
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Ingår i: Journal of Dispersion Science and Technology. - : Informa UK Limited. - 0193-2691 .- 1532-2351. ; 28:2, s. 223-230
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Tidskriftsartikel (refereegranskat)abstract
- Using NMR self-diffusion and H-2-NMR relaxation experiments, we have investigated growth of oil-in-water microemulsion droplets when spontaneous curvature is lowered, starting at emulsification failure boundary. We compare two ternary nonionic microemulsion systems, containing penta-ethylene glycol dodecyl ether (C12E5), and decane or hexadecane, at same surfactant-to-oil ratio and approximately the same spontaneous curvature. Droplet growth in microemulsions appears in general to be only minor. Quantitative differences between the two systems indicate differences in the curvature elastic constants.
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| 22. |
- Balogh, Joakim, et al.
(författare)
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Dependence on oil chain length of the curvature elastic properties of nonionic surfactant films: Emulsification failure and phase equilibria
- 2006
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Ingår i: Journal of Dispersion Science and Technology. - : Informa UK Limited. - 0193-2691 .- 1532-2351. ; 27:4, s. 497-510
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Tidskriftsartikel (refereegranskat)abstract
- We compare two ternary microemulsions, stabilized by the nonionic surfactant pentaethylene-glycol-dodecyl-ether (C12E5), containing decane or hexadecane. The comparison involves phase behavior and properties of O/W droplet microemulsions investigated with SAXS, static and dynamic light scattering, and NMR. Striking differences are observed. The systems are analyzed in terms of curvature elastic properties of surfactant film. Apart from an increase of the spontaneous curvature, there also appears to be a small but significant increase in the saddle splay constant as the oil chain length is increased.
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| 23. |
- Balogh, Joakim, et al.
(författare)
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Effects of oil on the curvature elastic properties of nonionic surfactant films: Thermodynamics of balanced microemulsions
- 2006
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Ingår i: Physical Review E (Statistical, Nonlinear, and Soft Matter Physics). - 1539-3755. ; 73:4: 041506
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Tidskriftsartikel (refereegranskat)abstract
- The free energy of nonionic balanced microemulsions based on nonionic surfactants are analyzed using experimental data from (i) phase behavior, (ii) osmotic compressibility of the balanced microemulsion structure, which is obtained from small angle neutron scattering (SANS) experiments, and (iii) data on interfacial tensions obtained by T. Sottmann and R. Strey [J. Chem. Phys. 106 8606 (1997)]. The balanced microemulsion, where the spontaneous curvature vanishes at equal volumes of water and oil, has a finite swelling with the solvent with a minimum surfactant volume fraction, Phi(*)(S). At higher surfactant concentrations the balanced microemulsion phase having the surfactant volume fraction Phi(S1) coexists with a lamellar phase of volume fraction Phi(S2). Under the constraint of Phi(W)=Phi(O), where Phi(W) and Phi(O) are the water and oil volume fractions, respectively, the free energy density can be written as an expansion in the surfactant concentration. While the phase equilibria only depend on relative values of the expansion coefficients, absolute values can be obtained from compressibility and interfacial tension data. The osmotic compressibility of the surfactant film was measured by SANS through contrast matching water and oil. The phase behavior of nonionic surfactant-water-oil systems depends strongly on the chain length of the oil, when comparing a homologous series from octane to hexadecane using the same surfactant, here being pentaethylene oxide dodecyl ether (C12E5). The three concentrations Phi(*)(S), Phi(S1), and Phi(S2) increase markedly as the chain length of the oil is increased. However, from the analysis of the surface tension data it is concluded that there are no major changes in the bending rigidities as the oil is changed. The data are analyzed within the model free energy densities G/V=a(3)Phi(3)(S)+a(5)Phi(5)(S) and G/V=a Phi(3)(S)(1+b ln Phi(S)). We find that within experimental accuracy, the first of these models provides a quantitatively consistent description of the data. For the second model there is a larger discrepancy between observed and calculated values.
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| 24. |
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| 25. |
- Barnevik Olsson, Martina, et al.
(författare)
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Autism before diagnosis : crying, feeding and sleeping problems in the first two years of life
- 2013
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 102:6, s. 635-639
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Tidskriftsartikel (refereegranskat)abstract
- Aim To chart early registered regulatory problems (RP) in a representative group of young children with and without autism spectrum disorder (ASD). Methods The target group comprised 208 preschool children with ASD, whose records from the Child Health Centres (CHC) were reviewed regarding numbers of consultations for excessive crying, feeding and sleeping problems. The records from an age- and gender-matched comparison group were obtained from the same CHCs as those of the index children Results Significant differences between the ASD and comparison groups were found for each domain studied and when domains were collapsed. Two or more consultations had occurred in 44% of the children in the ASD group and in 16% of the comparison group (p<0.001). No correlations were found with regard to gender, later severity of autism, cognitive level or degree of hyperactivity. Conclusion Regulatory problems (RP) were much more common in children who later received a diagnosis of ASD. Children with many RP in infancy require attention from CHC and paediatric services and need to be followed with regard to development and family support.
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| 26. |
- Barnevik Olsson, Martina, et al.
(författare)
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Children with borderline intellectual functioning and autism spectrum disorder : developmental trajectories from 4 to 11 years of age
- 2017
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Ingår i: Neuropsychiatric Disease and Treatment. - 1176-6328 .- 1178-2021. ; 13, s. 2519-2526
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies on autism have tended to focus either on those with intellectual disability (ie, those with intellectual quotient [IQ] under 70) or on the group that is referred to as high-functioning, that is, those with borderline, average or above average IQ. The literature on cognition and daily functioning in autism spectrum disorder combined specifically with borderline intellectual functioning (IQ 70-84) is limited. Methods: From a representative group of 208 preschool children diagnosed with autism spectrum disorder, those 50 children in the group with borderline intellectual functioning at ages 4.5-6.5 years were targeted for follow-up at a median age of 10 years. A new cognitive test was carried out in 30 children. Parents were interviewed with a semi-structured interview together with the Vineland Adaptive Behavior Scales (n=41) and the Autism-Tics, attention-deficit/hyperactivity disorder (AD/HD) and other comorbidities inventory (A-TAC) (n=36). Results: Most children of interviewed parents presented problems within several developmental areas. According to A-TAC and the clinical interview, there were high rates of attention deficits and difficulties with regulating activity level and impulsivity. Vineland Adaptive Behavior Scales composite scores showed that at school age, a majority of the children had declined since the previous assessment at ages between 4.5 and 6.5 years. Almost half the tested group had shifted in their IQ level, to below 70 or above 84. Conclusion: None of the children assessed was without developmental/neuropsychiatric problems at school-age follow-up. The results support the need for comprehensive follow-up of educational, medical and developmental/neuropsychiatric needs, including a retesting of cognitive functions. There is also a need for continuing parent/family follow-up and support.
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| 27. |
- Barnevik Olsson, Martina, et al.
(författare)
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Children with borderline intellectual functioning and autism spectrum disorder: developmental trajectories from 4 to 11 years of age
- 2017
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Ingår i: Neuropsychiatric Disease and Treatment. - : Informa UK Limited. - 1178-2021. ; 13, s. 2519-2526
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Studies on autism have tended to focus either on those with intellectual disability (ie, those with intellectual quotient [IQ] under 70) or on the group that is referred to as "high-functioning", that is, those with borderline, average or above average IQ. The literature on cognition and daily functioning in autism spectrum disorder combined specifically with borderline intellectual functioning (IQ 70-84) is limited. Methods: From a representative group of 208 preschool children diagnosed with autism spectrum disorder, those 50 children in the group with borderline intellectual functioning at ages 4.5-6.5 years were targeted for follow-up at a median age of 10 years. A new cognitive test was carried out in 30 children. Parents were interviewed with a semi-structured interview together with the Vineland Adaptive Behavior Scales (n=41) and the Autism-Tics, attention-deficit/hyperactivity disorder (AD/HD) and other comorbidities inventory (A-TAC) (n=36). Results: Most children of interviewed parents presented problems within several developmental areas. According to A-TAC and the clinical interview, there were high rates of attention deficits and difficulties with regulating activity level and impulsivity. Vineland Adaptive Behavior Scales composite scores showed that at school age, a majority of the children had declined since the previous assessment at ages between 4.5 and 6.5 years. Almost half the tested group had shifted in their IQ level, to below 70 or above 84. Conclusion: None of the children assessed was without developmental/neuropsychiatric problems at school-age follow-up. The results support the need for comprehensive follow-up of educational, medical and developmental/neuropsychiatric needs, including a retesting of cognitive functions. There is also a need for continuing parent/family follow-up and support.
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| 28. |
- Barnevik Olsson, Martina, et al.
(författare)
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Preschool to School in Autism : Neuropsychiatric Problems 8 Years After Diagnosis at 3 Years of Age
- 2016
-
Ingår i: Journal of autism and developmental disorders. - : Springer Science and Business Media LLC. - 0162-3257 .- 1573-3432. ; 46:8, s. 2749-2755
-
Tidskriftsartikel (refereegranskat)abstract
- The study presents neuropsychiatric profiles of children aged 11 with autism spectrum disorder, assessed before 4.5 years, and after interventions. The original group comprised a community sample of 208 children with ASD. Parents of 128 participated-34 with average intellectual function, 36 with borderline intellectual function and 58 with intellectual disability. They were interviewed using the Autism-Tics, AD/HD and other Comorbidities interview. Criteria for a clinical/subclinical proxy of ASD were met by 71, 89 and 95 %, respectively. Criteria for at least one of ASD, AD/HD, Learning disorder or Developmental Coordination Disorder were met by 82, 94 and 97 %. More than 90 % of children with a preschool diagnosis of ASD have remaining neuropsychiatric problems at 11, despite early intervention.
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| 29. |
- Barnevik Olsson, Martina, et al.
(författare)
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Recovery from the diagnosis of autism - and then?
- 2015
-
Ingår i: Neuropsychiatric Disease and Treatment. - 1176-6328 .- 1178-2021. ; 11, s. 999-1005
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of this study was to follow up the 17 children, from a total group of 208 children with autism spectrum disorder (ASD), who recovered from autism. They had been clinically diagnosed with ASD at or under the age of 4 years. For 2 years thereafter they received intervention based on applied behavior analysis. These 17 children were all of average or borderline intellectual functioning. On the 2-year follow-up assessment, they no longer met criteria for ASD. Methods: At about 10 years of age they were targeted for a new follow-up. Parents were given a semistructured interview regarding the child's daily functioning, school situation, and need of support, and were interviewed using the Vineland Adaptive Behavior Scales (VABS) and the Autism - Tics, Attention-deficit/hyperactivity disorder (AD/HD), and other Comorbidities (A-TAC) telephone interview. Results: The vast majority of the children had moderate-to-severe problems with attention/activity regulation, speech and language, behavior, and/or social interaction. A majority of the children had declined in their VABS scores. Most of the 14 children whose parents were A-TAC-interviewed had problems within many behavioral A-TAC domains, and four (29%) had symptom levels corresponding to a clinical diagnosis of ASD, AD/HD, or both. Another seven children (50%) had pronounced subthreshold indicators of ASD, AD/HD, or both. Conclusion: Children diagnosed at 2-4 years of age as suffering from ASD and who, after appropriate intervention for 2 years, no longer met diagnostic criteria for the disorder, clearly needed to be followed up longer. About 3-4 years later, they still had major problems diagnosable under the umbrella term of ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations). They continued to be in need of support, educationally, from a neurodevelopmental and a medical point of view. According to parent interview data, a substantial minority of these children again met diagnostic criteria for ASD.
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| 30. |
- Belgrano, Andrea, et al.
(författare)
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Överfiske - en miljöfarlig aktivitet : orsaker till fiskbeståndens utarmning och dess konsekvenser i svenska hav
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Bestånden av marina fiskarter har minskat dramatiskt i både Västerhavet och i Östersjön under de senaste 100 åren. Flera olika faktorer påverkar fiskbeståndens storlek, men ett ökande antal studier tyder på att överfiske är en huvudorsak i de flesta fall. Fisket med trål anses också skada många bottenlevande organismer, men det är idag oklart hur omfattande denna miljöpåverkan är. Vidare tyder nya studier på att förlusten av stora rovfiskar kan ge negativa effekter på hela ekosystem genom trofiska kedjereaktioner. Sammantaget anser många forskare idag att fisket utgör ett av de allvarligaste miljöhoten mot svenska hav. Denna rapport sammanställer det vetenskapliga kunskapsläget över orsakerna till nedgången av svenska marina fiskbestånd, samt fiskets roll för minskning av biodiversitet och förändringar i svenska kust- och utsjöekosystem.
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| 31. |
- Bergström, Petra, et al.
(författare)
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Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Amyloid precursor protein (APP) and its cleavage product amyloid beta (A beta) have been thoroughly studied in Alzheimer's disease. However, APP also appears to be important for neuronal development. Differentiation of induced pluripotent stem cells (iPSCs) towards cortical neurons enables in vitro mechanistic studies on human neuronal development. Here, we investigated expression and proteolytic processing of APP during differentiation of human iPSCs towards cortical neurons over a 100-day period. APP expression remained stable during neuronal differentiation, whereas APP processing changed. alpha-Cleaved soluble APP (sAPP alpha) was secreted early during differentiation, from neuronal progenitors, while beta-cleaved soluble APP (sAPP beta) was first secreted after deep-layer neurons had formed. Short A beta peptides, including A beta 1-15/16, peaked during the progenitor stage, while processing shifted towards longer peptides, such as A beta 1-40/42, when post-mitotic neurons appeared. This indicates that APP processing is regulated throughout differentiation of cortical neurons and that amyloidogenic APP processing, as reflected by A beta 1-40/42, is associated with mature neuronal phenotypes.
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| 32. |
- Bernardo, Ricardo, et al.
(författare)
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Combined solar and membrane drying technologies for sustainable fruit preservation in low-income countries – prototype development, modelling, and testing
- 2021
-
Ingår i: Solar Energy Advances. - : Elsevier BV. - 2667-1131. ; 1
-
Tidskriftsartikel (refereegranskat)abstract
- This investigation consisted of developing and evaluating solar dryers together with semi-permeable membrane pouches for drying juicy fruits in low-income tropical countries. Two design iterations were carried out including prototype modelling and testing. The latest developed solar dryers were a passive and an active solar dryer. Modelling was initially carried out mathematically using an equation solver software followed by computational fluid dynamics. Preliminary measurements were carried out on a small-scale solar dryer. Thereafter, full-scale models were developed and tested, both in laboratory and in real conditions in Mozambique. Results from modelling were validated against measurements in laboratory in Sweden and field trials in Mozambique. Prototype building and testing in Mozambique was undertaken in collaboration with local farmers and a university. Measurement results show that the dryers help to prevent microbial growth through increased temperatures. The drying flux was increased by 50% for the passive, and by 100% for the active solar dryers compared to the ambient controls that did not use a solar dryer. The total drying time was below four days for all pouches in the dryers. The active solar dryer was shown to have the shortest drying time and the highest capacity (more pouches) but also the highest costs. Mould growth and juice fermentation were observed on control pouches drying in open air. These problems were solved with the use of solar dryer technology. However, some challenges with the membrane pouches require further development including degradation of the membrane when exposed to direct sunlight.
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| 33. |
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| 34. |
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| 35. |
- Blideanu, V., et al.
(författare)
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Nucleon-induced reactions at intermediate energies : New data at 96 MeV and theoretical status
- 2004
-
Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 70:1, s. 014607-
-
Tidskriftsartikel (refereegranskat)abstract
- Double-differential cross sections for light charged particle production (up to A=4) were measured in 96 MeV neutron-induced reactions, at the TSL Laboratory Cyclotron in Uppsala (Sweden). Measurements for three targets, Fe, Pb, and U, were performed using two independent devices, SCANDAL and MEDLEY. The data were recorded with low-energy thresholds and for a wide angular range (20°–160°). The normalization procedure used to extract the cross sections is based on the np elastic scattering reaction that we measured and for which we present experimental results. A good control of the systematic uncertainties affecting the results is achieved. Calculations using the exciton model are reported. Two different theoretical approaches proposed to improve its predictive power regarding the complex particle emission are tested. The capabilities of each approach is illustrated by comparison with the 96 MeV data that we measured, and with other experimental results available in the literature.
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| 36. |
- Blomgren, Jan, et al.
(författare)
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How Strong is the Strong Interaction?
- 2004
-
Ingår i: Proceedings of the InternationalWorkshop on Nuclear Data for the Transmutation of Nuclear Waste. - 3000122761
-
Konferensbidrag (refereegranskat)
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| 37. |
- Borg, Markus, et al.
(författare)
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Illuminating a Blind Spot in Digitalization - Software Development in Sweden's Private and Public Sector
- 2020
-
Ingår i: Proceedings - 2020 IEEE/ACM 42nd International Conference on Software Engineering Workshops, ICSEW 2020. - New York, NY, USA : Association for Computing Machinery, Inc. - 9781450379632 ; , s. 299-302
-
Konferensbidrag (refereegranskat)abstract
- As Netscape co-founder Marc Andreessen famously remarked in 2011, software is eating the world - becoming a pervasive invisible critical infrastructure. Data on the distribution of software use and development in society is scarce, but we compile results from two novel surveys to provide a fuller picture of the role software plays in the public and private sectors in Sweden, respectively. Three out of ten Swedish firms, across industry sectors, develop software in-house. The corresponding figure for Sweden's government agencies is four out of ten, i.e., the public sector should not be underestimated. The digitalization of society will continue, thus the demand for software developers will further increase. Many private firms report that the limited supply of software developers in Sweden is directly affecting their expansion plans. Based on our findings, we outline directions that need additional research to allow evidence-informed policy-making. We argue that such work should ideally be conducted by academic researchers and national statistics agencies in collaboration. © 2020 ACM.
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| 38. |
- Brolin Låftman, Sara, 1974-, et al.
(författare)
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Perceived problematic alcohol use in the family and adolescents’ stress-related complaints : examining the buffering role of the school’s degree of student focus as rated by its teachers
- 2023
-
Ingår i: BMC Public Health. - 1471-2458. ; 23
-
Tidskriftsartikel (refereegranskat)abstract
- Background A non-negligible proportion of children grow up with problematic alcohol use in the family. Problematic familial drinking can be regarded as a stressor, and prior studies have consistently reported poorer mental health among adolescents who are exposed. However, it is also of relevance to identify modifiable protective factors which may buffer against stress-related ill-health in this group of adolescents. One context where such factors may be present is the school. The aim of this study is to examine the relationship between perceived problematic familial alcohol use and students’ stress-related complaints, and specifically to explore if the school’s degree of student focus can buffer against any such negative health consequences of problem drinking at home.Methods Data were drawn from four separate surveys, the Stockholm School Survey (SSS) and the Stockholm Teacher Survey (STS) conducted in 2014 and 2016 among 7,944 students (~ 15–16 years) and 2,024 teachers in 147 Stockholm senior-level school units. Perceived problematic familial alcohol use was measured by one item in the SSS. Stress-related complaints were captured by co-occurring somatic complaints and psychological distress, and reported by students in the SSS. The school’s student focus was measured by an index based on teachers’ ratings of four items in the STS. A set of covariates at the student and the school level were also included. Two-level binary logistic and linear regression models were performed.Results Perceived problematic familial alcohol use was linked with an increased likelihood of reporting co-occurring somatic complaints as well as psychological distress. Cross-level interactions revealed that the association between perceived problematic familial alcohol use and co-occurring somatic complaints was weaker among students attending schools with stronger teacher-rated student focus. Regarding psychological distress, the association was weaker for students attending schools with intermediate or strong teacher-rated student focus, compared with those attending schools with weaker teacher-rated student focus.Conclusions The findings provide support for the assumption that favourable conditions in schools can buffer against negative health consequences of problematic conditions in the family, thus serving a compensatory role.
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| 39. |
- Brolin Låftman, Sara, et al.
(författare)
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Problematic alcohol use in the family and adolescents’ stress-related complaints
- 2021
-
Ingår i: European Journal of Public Health. - : Oxford University Press (OUP).
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background. A non-negligible proportion of children grow up in families where problematic alcohol use is present. From a resilience perspective and for the implementation of effective interventions, it is relevant to examine to what extent favourable conditions in other contexts may buffer against such family adversities. The aim of the current study was to examine the relationship between problematic familial alcohol use and offspring stress-related complaints. Another aim was to explore whether teacher ratings of the school's degree of student focus can buffer against negative health consequences of problem drinking at home.Methods. Data were drawn from four cross-sectional surveys conducted in 2014 and in 2016 among 8,728 students (∼15-16 years) and 2,024 teachers in 147 Stockholm senior-level school units, with linked school-level register information. Stress-related complaints were measured from students' reports on the weekly co-occurrence of stomach-ache and headache. Teachers' ratings of the school's student focus were measured by an index based on four items which was aggregated to the school level. Student-level sociodemographic characteristics were included as control variables along with the schools' composition and student-teacher ratio. Two-level binary logistic regression analyses were performed.Results. Problematic familial alcohol use was associated with an increased likelihood of stress-related complaints among students (OR 1.74, 95% CI 1.44-2.10). The cross-level interaction revealed that this association was weaker among students in schools with higher levels of student focus.Conclusions. The study showed that the association between problematic familial alcohol use and students' stress-related complaints was less pronounced in schools with higher teacher ratings of student focus. This finding indicates that favourable conditions in schools can buffer against problematic conditions in the family, thus serving a compensatory role.Key messages. Students reporting problematic familial alcohol use were more likely to suffer from stress-related complaints.High teacher ratings of the school’s student focus buffered against the association between problematic familial alcohol use and stress-related complaints.
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| 40. |
- Brown, Darron R., et al.
(författare)
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The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Generally HPV-Naive Women Aged 16-26 Years
- 2009
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Ingår i: Journal Of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 199:7, s. 926-935
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Konferensbidrag (refereegranskat)abstract
- Background. Human papillomavirus (HPV)-6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18-related cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types was evaluated. Methods. We enrolled 17,622 women aged 16-26 years. All underwent cervicovaginal sampling and Pap testing at regular intervals for up to 4 years. HPV genotying was performed for biopsy samples, and histological diagnoses were determined by a pathology panel. Analyses were conducted among subjects who were negative for 14 HPV types on day 1. Prespecified analyses included infection of >= 6 months' duration and CIN1-3/AIS due to the 2 and 5 most common HPV types in cervical cancer after HPV types 16 and 18, as well as all tested nonvaccine types. Results. Vaccination reduced the incidence of HPV-31/45 infection by 40.3% (95% confidence interval [CI], 13.9% to 59.0%) and of CIN1-3/AIS by 43.6% (95% CI, 12.9% to 64.1%), respectively. The reduction in HPV-31/33/45/52/58 infection and CIN1-3/AIS was 25.0% (95% CI, 5.0% to 40.9%) and 29.2% (95% CI, 8.3% to 45.5%), respectively. Efficacy for CIN2-3/AIS associated with the 10 nonvaccine HPV types was 32.5% (95% CI, 6.0% to 51.9%). Reductions were most notable for HPV-31. Conclusions. HPV-6/11/16/18 vaccine reduced the risk of CIN2-3/AIS associated with nonvaccine types responsible for similar to 20% of cervical cancers. The clinical benefit of cross-protection is not expected to be fully additive to the efficacy already observed against HPV-6/11/16/18-related disease, because women may have >1 CIN lesion, each associated with a different HPV type.
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| 41. |
- Burden, Håkan, et al.
(författare)
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Självkörande landsbygd
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Hur skulle autonoma fordon kunna användas inom kollektivtrafiken på landsbygden? Genom intervjuer, workshops och en RFI (request for information, ett första steg mot upphandling) har vi undersökt frågan utifrån fyra konkreta områden i Sverige – Lund, Gotland, Eskilstuna och Skellefteå. Med en definition av landsbygd baserad på individens mobilitet har vi sett att Sveriges landsbygd rymmer mindre orter på väg att avfolkas där äldre, barn och de utan körkort hade kunnat få bättre tillgång till samhällelig service med autonoma fordon. Vi har också sett att flera av landets nya arbetsplatser kommer befinna sig på landsbygden och därmed skapa ett mobilitetsbehov från staden till landet. För att kunna realisera de identifierade möjligheterna finns ett behov av att framföra fordonen i högre hastigheter samt att de ska kunna hantera mer komplexa trafiksituationer än vad dagens piloter i städerna visat. På landsbygden finns alltså ett utrymme för nya fordon att visa upp sig. Samtidigt ser vi hur man inte ska förvänta sig att investeringarna i autonoma fordon kommer betala sig på en linje, snarare behöver man lyfta blicken och se systemeffekten när stomlinjetrafiken blir mer attraktiv då bussarna går raka vägen istället för via mindre samhällen. Vi har inte sett några belägg på att den digitala infrastrukturen behöver utvecklas för att möjliggöra försök med autonoma fordon på någon av de undersökta rutterna. Dagens 4G-täckning är fullgod och fordonen borde ha tillgång till tillräckligt bra positioneringsdata för att bedriva verksamheten. Däremot ställs flera frågor om hur ersättningstrafiken organiseras när fordonen inte klarar av vädret, vem som står för säkrare hållplatser och hur chaufförens övriga ansvar realiseras när fordonet är förarlöst.
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| 42. |
- Carlstedt, Anders, et al.
(författare)
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Management of Diastasis of the Rectus Abdominis Muscles : Recommendations for Swedish National Guidelines
- 2021
-
Ingår i: Scandinavian Journal of Surgery. - : Sage Publications. - 1457-4969 .- 1799-7267. ; 10:3, s. 452-459
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Diastasis of the rectus abdominis muscle is a common condition. There are no generally accepted criteria for diagnosis or treatment of diastasis of the rectus abdominis muscle, which causes uncertainty for the patient and healthcare providers alike. Methods: The consensus document was created by a group of Swedish surgeons and based on a structured literature review and practical experience. Results: The proposed criteria for diagnosis and treatment of diastasis of the rectus abdominis muscle are as follows: (1) Diastasis diagnosed at clinical examination using a caliper or ruler for measurement. Diagnostic imaging by ultrasound or other imaging modality, should be performed when concurrent umbilical or epigastric hernia or other cause of the patient's symptoms cannot be excluded. (2) Physiotherapy is the firsthand treatment for diastasis of the rectus abdominis muscle. Surgery should only be considered in diastasis of the rectus abdominis muscle patients with functional impairment, and not until the patient has undergone a standardized 6-month abdominal core training program. (3) The largest width of the diastasis should be at least 5 cm before surgical treatment is considered. In case of pronounced abdominal bulging or concomitant ventral hernia, surgery may be considered in patients with a smaller diastasis. (4) When surgery is undertaken, at least 2 years should have elapsed since last childbirth and future pregnancy should not be planned. (5) Plication of the linea alba is the firsthand surgical technique. Other techniques may be used but have not been found superior. Discussion: The level of evidence behind these statements varies, but they are intended to lay down a standard strategy for treatment of diastasis of the rectus abdominis muscle and to enable uniformity of management.
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| 43. |
- Dahlin, Joakim S., et al.
(författare)
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KIT signaling is dispensable for human mast cell progenitor development
- 2017
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 130:16, s. 1785-1794
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Tidskriftsartikel (refereegranskat)abstract
- Human hematopoietic progenitors are generally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the formation of mast cells. Imatinib treatment, which inhibits KIT signaling, depletes mast cells in vivo. Furthermore, the absence of SCF or imatinib treatment prevents progenitors from developing into mast cells in vitro. However, these observations do not mean that mast cell progenitors require SCF and KIT signaling throughout differentiation. Here, we demonstrate that circulating mast cell progenitors are present in patients undergoing imatinib treatment. In addition, we show that mast cell progenitors from peripheral blood survive, mature, and proliferate without SCF and KIT signaling in vitro. Contrary to the prevailing consensus, our results show that SCF and KIT signaling are dispensable for early mast cell development.
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| 44. |
- Davidsson, Henrik, et al.
(författare)
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Towards a homogenous drying rate using a solar fruit dryer
- 2017
-
Ingår i: ISES, International solar energy society, Solar World Congress 29 Oct – 02 Nov 2017, Abu Dhabi, UAE. - Freiburg, Germany : International Solar Energy Society. - 9783981465976
-
Konferensbidrag (refereegranskat)abstract
- Solar fruit drying has the potential to reduce food insecurity in developing nations. One possible technique for drying fruit is to use solar dryers. This technique is easy to use without requiring high investments. However, the drying technique can be challenging. One problem is that the drying rate could be different depending on where in the dryer the process takes place. At the beginning of the dryer, the air is dry and warm while at the exit it has picked up moisture from the products and has cooled down. This could result in severe problems for the user. One possible solution is to have an arrangement that inverts the direction of the airflow periodically. This means that the entrance and the exit of the air are shifted. Thus, the drying rate evens out. Results from the performed simulations shows that the difference in drying rate comparing the fastest with the slowest drying rate in the dryer can be reduced from approximately 110 % to 10 % with this approach. Furthermore, this paper also describes how weather condition for a design day was established. This weather condition can be used for more accurate estimates regarding drying rates and temperatures in the solar dryer.
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| 45. |
- De Knoop, Ludvig, 1972, et al.
(författare)
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Electric-field-controlled reversible order-disorder switching of a metal tip surface
- 2018
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Ingår i: Physical Review Materials. - 2475-9953. ; 2:8
-
Tidskriftsartikel (refereegranskat)abstract
- While it is well established that elevated temperatures can induce surface roughening of metal surfaces, the effect of a high electric field on the atomic structure at ambient temperature has not been investigated in detail. Here we show with atomic resolution using in situ transmission electron microscopy how intense electric fields induce reversible switching between perfect crystalline and disordered phases of gold surfaces at room temperature. Ab initio molecular dynamics simulations reveal that the mechanism behind the structural change can be attributed to a vanishing energy cost in forming surface defects in high electric fields. Our results demonstrate how surface processes can be directly controlled at the atomic scale by an externally applied electric field, which promotes an effective decoupling of the topmost surface layers from the underlying bulk. This opens up opportunities for development of active nanodevices in, e.g., nanophotonics and field-effect transistor technology as well as fundamental research in materials characterization and of yet unexplored dynamically controlled low-dimensional phases of matter.
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| 46. |
- Dillner, Joakim, et al.
(författare)
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Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial.
- 2010
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Ingår i: BMJ: British Medical Journal. - : BMJ. - 1756-1833 .- 0959-8138 .- 1468-5833. ; 341
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). DESIGN: Data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (FUTURE II)). The trials were to be 4 years in length, and the results reported are from final study data of 42 months' follow-up. SETTING: Primary care centres and university or hospital associated health centres in 24 countries and territories around the world. PARTICIPANTS: 17 622 women aged 16-26 years enrolled between December 2001 and May 2003. Major exclusion criteria were lifetime number of sexual partners (>4), history of abnormal cervical smear test results, and pregnancy. INTERVENTION: Three doses of quadrivalent HPV vaccine (for serotypes 6, 11, 16, and 18) or placebo at day 1, month 2, and month 6. MAIN OUTCOME MEASURES: Vaccine efficacy against cervical, vulvar, and vaginal intraepithelial neoplasia grade I and condyloma in a per protocol susceptible population that included subjects who received all three vaccine doses, tested negative for the relevant vaccine HPV types at day 1 and remained negative through month 7, and had no major protocol violations. Intention to treat, generally HPV naive, and unrestricted susceptible populations were also studied. RESULTS: In the per protocol susceptible population, vaccine efficacy against lesions related to the HPV types in the vaccine was 96% for cervical intraepithelial neoplasia grade I (95% confidence interval 91% to 98%), 100% for both vulvar and vaginal intraepithelial neoplasia grade I (95% CIs 74% to 100%, 64% to 100% respectively), and 99% for condyloma (96% to 100%). Vaccine efficacy against any lesion (regardless of HPV type) in the generally naive population was 30% (17% to 41%), 75% (22% to 94%), and 48% (10% to 71%) for cervical, vulvar, and vaginal intraepithelial neoplasia grade I, respectively, and 83% (74% to 89%) for condyloma. CONCLUSIONS: Quadrivalent HPV vaccine provided sustained protection against low grade lesions attributable to vaccine HPV types (6, 11, 16, and 18) and a substantial reduction in the burden of these diseases through 42 months of follow-up. TRIAL REGISTRATIONS: NCT00092521 and NCT00092534.
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| 47. |
- Dynesius, Mats, et al.
(författare)
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Bryophyte species composition at the stand scale (1 ha) – Differences between secondary stands half a century after clear-cutting and older semi-natural boreal forests
- 2021
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Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 428
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Tidskriftsartikel (refereegranskat)abstract
- A growing proportion of the boreal biome consists of managed even-aged secondary forest stands regenerated after clear-cutting. Many disturbance-intolerant species may not be able to recolonize or reach their original abundance in these stands before the next clear-cutting, potentially causing large-scale biodiversity losses. Boreal bryophytes (mosses and liverworts) include many species intolerant to clear-cutting, and at small spatial scales species richness and occupancy has been shown to remain changed in secondary stands half a century after logging. To assess if such persistent changes occur also at the stand scale, we listed and estimated cover of all bryophyte species in 1-ha plots, comparing 14 secondary stands originating from clear-cutting 40–60 years earlier with 14 older semi-natural stands. The large plots also made it possible to assess differences in occupancy and abundance for more bryophyte species than in previous studies. Species composition differed significantly for both mosses and liverworts, but unlike earlier studies, we could not detect any significant difference between stand types in species numbers. Thirteen species were significantly associated with semi-natural stands and the total cover of liverworts was less than half in secondary stands. Secondary stands had significantly fewer species typically occurring under shady conditions and/or mostly growing on “tree substrates” (dead wood and/or bases and stems of living trees). Ordination analysis further emphasized the importance of shade and suitable deadwood substrates; the among-plot variation in bryophyte species composition was related to amount of coarse deadwood as well as to gradients from shady spruce dominated to open pine dominated stands and from polar- to equator-facing slopes. Besides lack of suitable habitat conditions in secondary stands, dispersal limitation may have caused a colonization time lag for some species. The clear importance of stand scale habitat conditions for bryophyte species composition calls for management adaptions to facilitate life boating and/or recolonization by ensuring availability of shade, coarse decomposing logs, and specific deciduous tree species (Populus, Salix, Sorbus) in secondary stands.
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| 48. |
- Ek, Ulla, et al.
(författare)
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Cognitive strengths and deficits in schoolchildren with ADHD.
- 2007
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Ingår i: Acta Paediatrica (Oslo, Norway : 1992). - : Wiley. - 0803-5253 .- 1651-2227. ; 96:5, s. 756-761
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Few studies provide detailed analyses of the various aspects of the entire cognitive profile of children with ADHD. MATERIAL AND METHODS: Cognitive test data were analysed for 10- to 11-year-old children with (1) ADHD, (2) subthreshold ADHD and (3) milder attention and/or learning problems, and compared with normative data. RESULTS: Thirty-two had ADHD and 10 met the criteria for subthreshold ADHD, prevalence rates of 5.4% and 1.6%, respectively. On a group level, children with ADHD/subthreshold ADHD, and those with milder attention and/or learning problems had almost identical cognitive profiles for the 13 subtests comprising the WISC III, with particularly low results on the arithmetic, coding, information and digit span subtests (ACID profile). When analyzed individually, a complete or incomplete ACID profile (three of four subtests) was equally common in children with ADHD/subthreshold ADHD and in children with milder problems, found in about 1/5. The relative strengths of both groups were in areas demanding logical thinking, reasoning and common sense. CONCLUSION: The specific ACID profile is as common in children with ADHD as in those with minor attention and/or learning problems. The cognitive weaknesses reflected in the ACID profile might play a role as an underlying factor in various developmental disorders.
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| 49. |
- Ekman, Inger, 1952, et al.
(författare)
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Person-centered care -ready for prime time.
- 2011
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Ingår i: European Journal of Cardiovascular Nursing. - : Sage Publications. - 1474-5151 .- 1873-1953. ; 10:4, s. 248-251
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Tidskriftsartikel (refereegranskat)abstract
- Long-term diseases are today the leading cause of mortality worldwide and are estimated to be the leading cause of disability by 2020. Person-centered care (PCC) has been shown to advance concordance between care provider and patient on treatment plans, improve health outcomes and increase patient satisfaction. Yet, despite these and other documented benefits, there are a variety of significant challenges to putting PCC into clinical practice. Although care providers today broadly acknowledge PCC to be an important part of care, in our experience we must establish routines that initiate, integrate, and safeguard PCC in daily clinical practice to ensure that PCC is systematically and consistently practiced, i.e. not just when we feel we have time for it. In this paper, we propose a few simple routines to facilitate and safeguard the transition to PCC. We believe that if conscientiously and systematically applied, they will help to make PCC the focus and mainstay of care in long-term illness.
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| 50. |
- Eriksson, Britas Klemens, et al.
(författare)
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Habitat segregation of plate phenotypes in a rapidly expanding population of three-spined stickleback
- 2021
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Ingår i: Ecosphere. - : Wiley. - 2150-8925 .- 2150-8925. ; 12:6
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Tidskriftsartikel (refereegranskat)abstract
- Declines of large predatory fish due to overexploitation are restructuring food webs across the globe. It is now becoming evident that restoring these altered food webs requires addressing not only ecological processes, but evolutionary ones as well, because human-induced rapid evolution may in turn affect ecological dynamics. We studied the potential for niche differentiation between different plate armor phenotypes in a rapidly expanding population of a small prey fish, the three-spined stickleback (Gasterosteus aculeatus). In the central Baltic Sea, three-spined stickleback abundance has increased dramatically during the past decades. The increase in this typical mesopredator has restructured near-shore food webs, increased filamentous algal blooms, and threatens coastal biodiversity. Time-series data covering 22 years show that the increase coincides with a decline in the number of juvenile perch (Perca fluviatilis), the most abundant predator of stickleback along the coast. We investigated the distribution of different stickleback plate armor phenotypes depending on latitude, environmental conditions, predator and prey abundances, nutrients, and benthic production; and described the stomach content of the stickleback phenotypes using metabarcoding. We found two distinct lateral armor plate phenotypes of stickleback, incompletely and completely plated. The proportion of incompletely plated individuals increased with increasing benthic production and decreasing abundances of adult perch. Metabarcoding showed that the stomach content of the completely plated individuals more often contained invertebrate herbivores (amphipods) than the incompletely plated ones. Since armor plates are defense structures favored by natural selection in the presence of fish predators, the phenotype distribution suggests that a novel low-predation regime favors stickleback with less armor. Our results suggest that morphological differentiation of the three-spined stickleback has the potential to affect food web dynamics and influence the persistence and resilience of the stickleback take-over in the Baltic Sea.
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