| 1. |
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| 2. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Aleman, Soo, et al.
(författare)
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Health check-ups and family screening allow detection of hereditary hemochromatosis with less advanced liver fibrosis and survival comparable with the general population
- 2011
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 46:9, s. 1118-1126
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Tidskriftsartikel (refereegranskat)abstract
- Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed. Results. Overall survival among these patients was not significantly different from that of a matched normal population. The patients diagnosed through health check-ups and family screening were detected at an earlier age and had the highest rate of survival. Liver biopsy at the time of diagnosis revealed cirrhosis in 9% of those detected through the health check-ups and 5% in the case of family screening, compared with 13% for the group with arthralgia, 17% for other diseases/symptoms and 42% for liver disease. Conclusion. Health check-ups and family screening allow detection of hereditary hemochromatosis at an earlier age and with less advanced liver fibrosis, although a few of these patients have already developed cirrhosis. Our study indicates that iron indices should be included in health check-ups, and if abnormal, should lead to further investigation.
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| 4. |
- Bäck, Sven, et al.
(författare)
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Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements
- 1999
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 1361-6560 .- 0031-9155. ; 44:8, s. 1983-1996
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Tidskriftsartikel (refereegranskat)abstract
- Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from that obtained using photon beams. However, on normalization at the entrance, the relative 1/T1 at the Bragg peak was 15-20% lower than the corresponding ionization chamber data for the monoenergetic proton beam. Better agreement was found for the modulated beam, but with significant differences close to the distal edge of the 1/T1 distribution. The change in sensitivity with depth was explained by means of a linear energy transfer dependence. This property was further studied using Monte Carlo methods.
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| 5. |
- Danielsson, Åke, et al.
(författare)
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A controlled randomized trial of budesonide versus prednisolone retention enemas in active distal ulcerative colitis
- 1987
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 22:8, s. 987-992
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Tidskriftsartikel (refereegranskat)abstract
- Sixty-four patients with active distal ulcerative colitis participated in a multicentre, randomized, investigator-blind trial to compare the effect of budesonide enema, 2 mg/100 ml, with prednisolone disodium phosphate enema, 31.25 mg/100 ml. Budesonide is a new potent corticosteroid with a rapid first-pass elimination. The patients were treated for 4 weeks, and the efficacy of the drugs were evaluated by sigmoidoscopy, histology, and subjective symptoms after 2 and 4 weeks. After 4 weeks of treatment 16 of 31 patients (52%) receiving budesonide enema had healed endoscopically, compared with 8 of 33 (24%) (p = 0.045) receiving prednisolone enema. Budesonide was superior to prednisolone in terms of both significantly improved sigmoidoscopic and histologic scores and subjective symptoms evaluated by visual analogue scales. The patients receiving prednisolone had a significant depression of endogenous cortisol levels during the treatment period, but not the patients receiving budesonide. Budesonide enema seems to be a promising therapy for active distal ulcerative colitis and causes no adverse reactions
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| 6. |
- Elmberg, Maria, et al.
(författare)
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Increased Mortality Risk in Patients With Phenotypic Hereditary Hemochromatosis But Not in Their First-Degree Relatives
- 2009
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 137:4, s. 1301-1309
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Hereditary hemochromatosis (HH) is an autosomal-recessive disorder characterized by iron overload. Relatives of HH patients were screened and those with HH-associated mutations and an increased iron load were identified. However, little is known about their mortality or strategies for their management. We assessed mortality among Swedish patients with HH and their first-degree relatives using health and census registers. METHODS: We performed a matched population-based cohort study of 3832 patients with HH and their 14,496 first-degree relatives using data collected from 1990 through 2007. Mortality data from these groups were compared with that of 38,969 population controls and their 143,349 first-degree relatives using Cox regression analyses. RESULTS: Patients identified on the basis of hospitalization with HH had an increased risk (relative risk [RR]) for death (RR, 2.45; 95% confidence interval [CI], 2.27-2.64; 857 deaths). Patients identified through other means had a mortality risk that was lower than those identified in the hospital but higher than controls (RR, 1.15; 95% CI, 1.00-1.33; 216 deaths). Their first-degree relatives had only a marginally increased mortality risk (RR, 1.05; 95% CI, 1.01-1.10); this RR was similar to that of patients' spouses (RR, 1.09; 95% CI, 0.86-1.38; 82 deaths). Patients with HH who also had a family history of HH did not have an increased mortality risk compared with other groups (RR, 1.05; 95% CI 0.67-1.62; 21 deaths). CONCLUSIONS: Patients with HH have a modestly increased mortality risk compared with controls. The mortality of relatives is increased marginally compared with controls, and is similar among biological and nonbiological relatives.
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| 7. |
- Escaned, Javier, et al.
(författare)
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Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes
- 2018
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Ingår i: JACC. - : Elsevier. - 1936-8798 .- 1876-7605. ; 11:15, s. 1437-1449
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization. METHODS The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated. Patients were stratified according to revascularization decision making on the basis of iFR or FFR and to clinical presentation (SAP or ACS). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization at 1 year. RESULTS Coronary revascularization was deferred in 2,130 patients. Deferral was performed in 1,117 patients (50%) in the iFR group and 1,013 patients (45%) in the FFR group (p < 0.01). At 1 year, the MACE rate in the deferred population was similar between the iFR and FFR groups (4.12% vs. 4.05%; fully adjusted hazard ratio: 1.13; 95% confidence interval: 0.72 to 1.79; p = 0.60). A clinical presentation with ACS was associated with a higher MACE rate compared with SAP in deferred patients (5.91% vs. 3.64% in ACS and SAP, respectively; fully adjusted hazard ratio: 0.61 in favor of SAP; 95% confidence interval: 0.38 to 0.99; p = 0.04). CONCLUSIONS Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used to assess physiological significance. In deferred patients presenting with ACS, the event rate was significantly increased compared with SAP at 1 year. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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| 8. |
- Furenbäck, Ingela, 1963-
(författare)
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Utveckling av samverkan : ett deltagarorienterat aktionsforskningsprojekt inom hälso- och sjukvård
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syfte: Det övergripande vetenskapliga syftet med denna avhandling att nå en ökad förståelse om samverkansprocesser.Ansats och metoder: Studien har bedrivits genom deltagarorienterad aktionsforskning inom hälso- och sjukvården i Hässleholm. Aktörer på verksamhetsfältet har strävat efter att utveckla samverkan för att tillsammans kunna utveckla närsjukvård. Forskningen har genererat kunskap utifrån lokala omständigheter att tjäna som underlag för beslut om att genomföra praktiska förändringar i verksamheten. En kombination av olika metoder har använts för att generera empiriskt material, där den huvudsakliga metoden har varit deltagande observationer med dialog. Därutöver har intervjuer och granskning av dokument använts samt en forskningscirkel, som är en speciell metod inom deltagarorienterad aktionsforskning. Studien har haft en hermeneutisk ansats och tolkningar har gjorts med stöd av olika teoretiska perspektiv och modeller. Kurt Lewins fältteori har utgjort en övergripande teoretisk ram för studien.Resultat: En ökad förståelse om den studerade samverkansprocessen kunde nås genom att beskriva och tolka skeenden som antogs ha påverkat utvecklingen av samverkan. Processen beskrevs både utifrån vertikal och horisontell integrering inom och mellan organisationer. Beskrivningen innefattade komponenter som fanns både inom arbetsprocesser och sociala processer. Den studerade samverkansprocessen delades in i delprocesser där var och en del innehöll en viss typ av aktivitet som genomfördes för att stödja utvecklingen av samverkan. Två olika strategier för utvecklingen av samverkan identifierades och illustrerades genom olika modeller: den linjära hierarkiska modellen respektive den dynamiska modellen. Den sistnämnda utvecklades genom aktionsforskningen.Slutsatser:I ett första skede bedrev deltagarna på fältet samverkan med stöd av den linjära hierarkiska modellen. Denna modell utgör ett tankeschema där samverkan utvecklas i en linjär hierarkisk process. Politiker fattar beslut, chefer planerar och professionella genomför aktiviteterna. Modellen utgår ifrån ett konsensusteoretiskt perspektiv där konflikter betraktas som störande element. Det innebar i detta fall att aktörer inom olika domäner och organisationer undvek varandras olika föreställningsvärldar varpå samverkansprocessen stötte på hinder i utvecklingen. Aktionsforskningen intervenerade i processen genom arrangera kommunikationsarenor med deltagare från olika domäner och organisationer. Samverkan utvecklades på så sätt utifrån den dynamiska modellen. Denna modell innehåller antaganden om att samverkansprocesser är dynamiska och har sin utgångspunkt i ett konfliktteoretiskt perspektiv där konflikter betraktas som naturliga i processen.
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| 9. |
- Götberg, Matthias, et al.
(författare)
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5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve
- 2022
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 79:10, s. 965-974
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking.OBJECTIVES: The purpose of this study was to investigate the prespecified 5-year follow-up of the primary composite outcome of all-cause mortality, myocardial infarction, and unplanned revascularization of the iFR-SWEDEHEART trial comparing iFR vs FFR in patients with chronic and acute coronary syndromes.METHODS: iFR-SWEDEHEART was a multicenter, controlled, open-label, registry-based randomized clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2,037 patients were randomized to undergo revascularization guided by iFR or FFR.RESULTS: No patients were lost to follow-up. At 5 years, the rate of the primary composite endpoint was 21.5% in the iFR group and 19.9% in the FFR group (HR: 1.09; 95% CI: 0.90-1.33). The rates of all-cause death (9.4% vs 7.9%; HR: 1.20; 95% CI: 0.89-1.62), nonfatal myocardial infarction (5.7% vs 5.8%; HR: 1.00; 95% CI: 0.70-1.44), and unplanned revascularization (11.6% vs 11.3%; HR: 1.02; 95% CI: 0.79-1.32) were also not different between the 2 groups. The outcomes were consistent across prespecified subgroups.CONCLUSIONS: In patients with chronic or acute coronary syndromes, an iFR-guided revascularization strategy was associated with no difference in the 5-year composite outcome of death, myocardial infarction, and unplanned revascularization compared with an FFR-guided revascularization strategy. (Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome [iFR SWEDEHEART]; NCT02166736)
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| 10. |
- Hindorf, Ulf, et al.
(författare)
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Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis.
- 2010
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Ingår i: Journal of Hepatology. - : Elsevier BV. - 0168-8278 .- 1600-0641. ; 52:1, s. 106-111
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and methylthioinosine monophosphate (meTIMP) metabolite measurements with regard to clinical outcome. METHODS: Two hundred thirty-eight patients with AiH were included in this cross-sectional study. TPMT status was assessed in all patients, while TGN and meTIMP were measured in patients with ongoing TP medication. Clinical outcome was evaluated by liver tests and the ability to withdraw steroids. RESULTS: TPMT genotyping (n=229) revealed 207 (90.4%) wild-type and 22 heterozygous patients. One hundred forty-three patients had ongoing TP therapy with AZA (n=134) or mercaptopurine (MP; n=9); response was judged as complete response (CR) in 113 patients and partial response (PR) in 30 patients. Both TP dose (1.64 vs 1.19mg/kg; p=0.012) and TPMT activity (14.3 vs 13.5; p=0.05) were higher in PR, resulting in similar TGN levels (PR: 121pmol/8x10(8) red blood cells [RBC]; CR: 113pmol/8x10(8) RBC; p=0.33) but higher meTIMP levels in PR (1350 vs 400pmol/8x10(8) RBC; p=0.004). Patients able to withdraw steroids or who were using 5mg prednisolone daily were treated with lower TP doses than patients on higher steroid doses (1.15 vs 1.18 vs 1.82mg/kg; p<0.001). CONCLUSIONS: TP metabolite measurements are of clinical value in AiH patients who do not respond to standard TP treatment and for the identification of a shifted metabolism, which may demand an alternative treatment strategy.
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| 11. |
- Jonsson, B. G., et al.
(författare)
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Skogspolitiken hotar biologiska mångfalden
- 2008
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Ingår i: Dagens Nyheter. ; 14 april
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Ledande svenska forskare varnar för att det nationella naturarvet äventyras: Vi skäms över våra beslutsfattares likgiltighet för miljön. Den svenska skogen har förvandlats till en jättelik odlingsyta. Där förr otaliga arter levde samman i harmoni dominerar numera helt gran, tall och inplanterade främmande trädslag. Denna skogsodling utgör ett hot mot den biologiska mångfalden vilket strider mot riksdagens miljökvalitetsmål. Den svenska skogspolitiken vilar officiellt på att produktion av skogsråvara och miljö är likvärdiga mål. Men i praktiken har produktionen satts i första rummet. Bortåt 2 000 skogslevande arters överlevnad hotas på grund av den förda politiken. Vi är djupt oroade och skäms över att det rika Sverige inte arbetar effektivt för att nå nationella och internationella miljömål. Det skriver 14 ledande forskare i bland annat växtekologi, ekologisk zoologi och botanik.
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| 12. |
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| 13. |
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| 14. |
- Olsson, Ann-Margreth E., 1952-, et al.
(författare)
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Finsamprojekt förebyggande arbete : Kartläggning och behovsanalys av förebyggande arbete mot våld i nära relationer i Bromölla, Hässleholm, Kristianstad, Osby och Östra Göinge kommuner samt Region Skåne och Försäkringskassan
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Kommunerna i Skåne Nordost var tidigt ute med planer mot våld 2005. Försäkringskassan har på central nivå starkt profilerat sig som en aktör som skall motverka mäns våld mot kvinnor, men det verkar inte ha fått genomslag, än så länge. Region Skåne har markerat sig i planarbete och utvecklande av metodverktyg, som Genushanden©, men fortfarande är praxis när det gället att Våga Fråga varierande. Samverkan mellan kommuner och Regionen i form av bl. a. Familjehus och föräldrautbildningsprogram, samtal och rådgivning lockar många deltagare. De är exempel på program för normpåverkan som i andra sammanhang visat sig fungera.Kommunerna samverkar, men har också gjort olika vägval. Hässleholm har satsat på sammanhållna processer inom kommunen, samverkan mellan tre förvaltningar och ett Familjefridscentrum som utvecklar och koordinerar arbetet mot våld i nära relationer. Övriga kommuner samverkar bland annat när det gäller spetskompetens genom Kriscentrum i Kristianstad. Alla kommuner satsar på förebyggande arbete genom bl.a. föräldrautbildningar. Samverkan med polis förefaller fungera bra när det gäller ungdom, men sämre när det handlar om kvinnor och/eller barn. Det framkom att det saknades stöd riktat till unga vuxna, där också personer som har eller kan vara aktuella för aktivitetsersättning återfinns. Det pågår och planeras fortsatt kompetensutveckling riktad till personal och genom KompetensCentrum. När det gäller Kristianstad kommun handlar det om 550 personer som skall gå utbildning.Viktiga områden att fokusera på framöver är: - Våga Fråga!, idag är stor variation. Frågeställaren behöver vara trygg i vad som kan göras och erbjudas vid upptäckt av våld eller hot om våld.- Mer information, utbildning och dialog inom och mellan verksamheter för att öka kompetens för överlämnande och tilltro till varandra som samverkanspartners.- Förebyggande insatser för unga vuxna.- Kopplingen arbetsliv – livet i övrigt. Ur arbetsgivarperspektiv går det att göra mycket när det gäller att upptäcka om anställd är utsatt för våld eller hot om våld såväl i arbetet som utanför arbetet.
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| 15. |
- Olsson, Ann-Margreth E., et al.
(författare)
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Finsamprojekt förebyggande arbete : Kartläggning och behovsanalys av förebyggande arbete mot våld i nära relationer i Bromölla, Hässleholm, Kristianstad, Osby och Östra Göinge kommuner samt Region Skåne och Försäkringskassan
- 2016
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Kommunerna i Skåne Nordost var tidigt ute med planer mot våld 2005. Försäkringskassan har på central nivå starkt profilerat sig som en aktör som skall motverka mäns våld mot kvinnor, men det verkar inte ha fått genomslag, än så länge. Region Skåne har markerat sig i planarbete och utvecklande av metodverktyg, som Genushanden©, men fortfarande är praxis när det gället att Våga Fråga varierande. Samverkan mellan kommuner och Regionen i form av bl. a. Familjehus och föräldrautbildningsprogram, samtal och rådgivning lockar många deltagare. De är exempel på program för normpåverkan som i andra sammanhang visat sig fungera. Kommunerna samverkar, men har också gjort olika vägval. Hässleholm har satsat på sammanhållna processer inom kommunen, samverkan mellan tre förvaltningar och ett Familjefridscentrum som utvecklar och koordinerar arbetet mot våld i nära relationer. Övriga kommuner samverkar bland annat när det gäller spetskompetens genom Kriscentrum i Kristianstad. Alla kommuner satsar på förebyggande arbete genom bl.a. föräldrautbildningar. Samverkan med polis förefaller fungera bra när det gäller ungdom, men sämre när det handlar om kvinnor och/eller barn. Det framkom att det saknades stöd riktat till unga vuxna, där också personer som har eller kan vara aktuella för aktivitetsersättning återfinns. Det pågår och planeras fortsatt kompetensutveckling riktad till personal och genom KompetensCentrum. När det gäller Kristianstad kommun handlar det om 550 personer som skall gå utbildning. Viktiga områden att fokusera på framöver är: - Våga Fråga!, idag är stor variation. Frågeställaren behöver vara trygg i vad som kan göras och erbjudas vid upptäckt av våld eller hot om våld. - Mer information, utbildning och dialog inom och mellan verksamheter för att öka kompetens för överlämnande och tilltro till varandra som samverkanspartners. - Förebyggande insatser för unga vuxna. - Kopplingen arbetsliv – livet i övrigt. Ur arbetsgivarperspektiv går det att göra mycket när det gäller att upptäcka om anställd är utsattför våld eller hot om våld såväl i arbetet som utanför arbetet.
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| 16. |
- Olsson, Ann-Margreth E., 1952-, et al.
(författare)
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In search of the voice of children : social workers as allies and gate-keepers
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- To improve a collaborative work a new institute has emerged in some places in Sweden, the Children’s House (CH), inspired by the Children’s Advocacy Center (CAC) model. In a CH professionals; police, prosecutors, health care and social services collaborate. One of the guiding ideas for CH is that the child should have to go to only one place during the investigatory process. In an ongoing dialogical participatory action research (DPAR) study the intention is to explore the children’s participation and understanding of CH. The aim is to support and secure a collaborative process with respect for the views of the child where the participating child becomes involved and listened to not only as a victim in an interrogation but as an actor.In developing evidence-based social work and learning in social work it becomes important that researchers are given opportunity to follow proceedings and listen to different voices including young clients. In the ongoing research project the researchers are participating observing the proceedings in CH and interviewing social workers asking them to mediate contact with participating children and their parents for the researcher. The researchers want to listen to the child’s view about visiting CH, the understanding of the context and the processes before, during and after visiting CH including the process of the social investigation and meetings with social workers.Several initiatives have been taken to improve participation within the child protection system, among these to develop social workers and social investigation processes from the perspective of being the child’s advocate. Evidence has emerged indicating that the ideas of inviting children into partnership with their social worker, are risking to be superseded by the priority to the forensic interview in CH, conducted by the police. The social workers report and show difficulties in knowing how to orientate themselves in relation to the children. The researcher’s request asking the social workers to invite the participating children and their parents into research collaboration seems to, so far, made the social workers to gate-keepers protecting the children from initiative reminding them of old abusive stories as well as severe proceedings.
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| 17. |
- Olsson, Ann-Margreth E., et al.
(författare)
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In search of the voice of children : social workers as allies and gate-keepers
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- To improve a collaborative work a new institute has emerged in some places in Sweden, the Children’s House (CH), inspired by the Children’s Advocacy Center (CAC) model. In a CH professionals; police, prosecutors, health care and social services collaborate. One of the guiding ideas for CH is that the child should have to go to only one place during the investigatory process. In an ongoing dialogical participatory action research (DPAR) study the intention is to explore the children’s participation and understanding of CH. The aim is to support and secure a collaborative process with respect for the views of the child where the participating child becomes involved and listened to not only as a victim in an interrogation but as an actor. In developing evidence-based social work and learning in social work it becomes important that researchers are given opportunity to follow proceedings and listen to different voices including young clients. In the ongoing research project the researchers are participating observing the proceedings in CH and interviewing social workers asking them to mediate contact with participating children and their parents for the researcher. The researchers want to listen to the child’s view about visiting CH, the understanding of the context and the processes before, during and after visiting CH including the process of the social investigation and meetings with social workers. Several initiatives have been taken to improve participation within the child protection system, among these to develop social workers and social investigation processes from the perspective of being the child’s advocate. Evidence has emerged indicating that the ideas of inviting children into partnership with their social worker, are risking to be superseded by the priority to the forensic interview in CH, conducted by the police. The social workers report and show difficulties in knowing how to orientate themselves in relation to the children. The researcher’s request asking the social workers to invite the participating children and their parents into research collaboration seems to, so far, made the social workers to gate-keepers protecting the children from initiative reminding them of old abusive stories as well as severe proceedings.
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| 18. |
- Olsson, Ann-Margreth E., 1952-
(författare)
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Swedish families' responses to military deployment
- 2019
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Ingår i: The politics of military families. - : Routledge. - 036713442X - 9780367134426 ; , s. 253-266
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Bokkapitel (refereegranskat)abstract
- This study examines emergent responses in Swedish families when a family member working in the Swedish Armed Forces get deployed in an international military operation. A descriptive design encompassing eight years of dialogical participatory action research was used. During this period, 110 adults and 25 children participated in individual and/or group dialogical interviews. Qualitative content analysis was applied and emergent suggestions were subsequently validated in dialogues with participants. This eventually resulted in six ideal types of responses: Partnership; Supporting and mobilizing; Normalizing – ordinary life; Adjusting and negotiating; Emotional reacting; Suffering. The types, recognized by participating family members, including the soldiers, emerge as a matrix for the narrations of experiences and connected responses to the deployment. The Swedish families reject the notion that the general concept of military families captured ‘who we are’. We discuss the meaning of this in the context of organization (the Swedish Armed Forces) and society (family, government/politics).
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| 19. |
- Snogerup, Sven, et al.
(författare)
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Skånska vegetationstyper
- 2003
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Ingår i: Floran i Skåne. Vegetation och utflyktsmål. - 9197102148 ; , s. 53-76
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Bokkapitel (populärvet., debatt m.m.)
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| 20. |
- Springett, Jane, 1952-, et al.
(författare)
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Närsjukvård : bakgrund, erfarenheter och pilotstudie
- 2005
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur olika aktörer i nordöstra Skåne uppfattar begreppet (Del B). Del A ger en översikt kring ursprunget till begreppet Närsjukvård inom ramen för de förändringar i hälso- och sjukvården som sker i Sverige i stort. Den beskriver sedan vilka slags förändringar som har planerats på politisk nivå och som nu håller på att genomföras under detta paraplybegrepp, nationellt, regionalt och lokalt. För detta syfte används statliga dokument och publicerade utvärderingsstudier i stor utsträckning som källmaterial. Denna del ska därför inte ses som en heltäckande översikt. Del B inriktas på att belysa hur långt förverkligandet av idén om Närsjukvård har kommit inom regionen. Avsnittet är en kartläggning av olika aktörers förståelse av Närsjukvård i den nordöstra delen av Region Skåne. Forskningsfrågorna inriktades på hur folk pratade om Närsjukvård, det vill säga på hur de förstod och använde begreppet.
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| 21. |
- Springett, Jane, et al.
(författare)
-
Närsjukvård : bakgrund, erfarenheter och pilotstudie
- 2005
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur olika aktörer i nordöstra Skåne uppfattar begreppet (Del B). Del A ger en översikt kring ursprunget till begreppet Närsjukvård inom ramen för de förändringar i hälso- och sjukvården som sker i Sverige i stort. Den beskriver sedan vilka slags förändringar som har planerats på politisk nivå och som nu håller på att genomföras under detta paraplybegrepp, nationellt, regionalt och lokalt. För detta syfte används statliga dokument och publicerade utvärderingsstudier i stor utsträckning som källmaterial. Denna del ska därför inte ses som en heltäckande översikt. Del B inriktas på att belysa hur långt förverkligandet av idén om Närsjukvård har kommit inom regionen. Avsnittet är en kartläggning av olika aktörers förståelse av Närsjukvård i den nordöstra delen av Region Skåne. Forskningsfrågorna inriktades på hur folk pratade om Närsjukvård, det vill säga på hur de förstod och använde begreppet.
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| 22. |
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| 23. |
- Villa, Luisa L., et al.
(författare)
-
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
-
Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 24. |
- von Bothmer, Roland, et al.
(författare)
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Jord : mylla, mark och makt
- 2017
-
Bok (populärvet., debatt m.m.)abstract
- Våra jordar är basen för en hållbar matproduktion. Vi har tagit jorden och jordarna för självklara men jordens hälsa är en garanti för framtiden. Jorden vi trampar på är av största vikt för allt levande på land. Med tanke på den alarmerande hastighet med vilken världens jordar håller på att förstöras är det viktigt att fästa uppmärksamheten på jord som en värdefull resurs som måste bevaras och utnyttjas skonsamt.Människans historia har varit beroende av hur vi skött eller misskött våra jordar. Våra jordar är dock så mycket mer än den geologiska och biologiska sfären. Jord är också ett laddat begrepp. Jorden bevarar spåren efter tidens flöde och berättar med sina på många ställen tjocka kulturlager. Den är ett arkiv över människans historia och utveckling.Jordens bördighet har varit grunden för alla stora kulturer på vår planet, och krig har utkämpats för att mätta hungern efter bördig jord. Under millennierna har jorden haft en stor symbolisk betydelse, Av jord är du kommen och fosterjorden är uttryck som visar det laddade värdet som jorden och myllan har. Att äga och bruka sin egen jord har under alla tider varit en drivkraft hos människan.Vi lever i människans tidevarv, Antropocen, och i dag är det vi som styr jordens naturgeografi. Är det en slump att rädda våra själar, Save Our Souls (S.O.S.), låter så lika rädda våra jordar, Save our Soils? Ande och materia är nära förbundna och att rädda den värdefulla jorden bidrar också till att rädda oss själva. Är det också en slump att den jorden vi odlar i är homonym till planeten Jorden vi bor på när den astronomiskt korrekta termen egentligen är planeten Tellus?Med denna essäantologi vill vi belysa komplexiteten i begreppet jord och hur dess betydelse genomsyrar hela vår tillvaro. Den är ett möte mellan humaniora, naturvetenskap och agrikultur och syftar till att öka kunskapen och förståelsen om vår sköna och sköra jord.
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| 25. |
- Wallerstedt, Sven, 1944, et al.
(författare)
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Abdominal tenderness in ascites patients indicates spontaneous bacterial peritonitis
- 2007
-
Ingår i: European journal of internal medicine. - : Elsevier BV. - 0953-6205 .- 1879-0828. ; 18:1, s. 44-47
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Spontaneous bacterial peritonitis (SBP), which has been reported to be present in 10-30% of patients with cirrhotic ascites, may easily be overlooked. An important aim of our study was to determine whether there are any clinical signs which, in clinical practice, may predict or exclude SBP. Methods: We studied 133 patients with cirrhotic ascites from medical units at nine Swedish university hospitals where there had been at least one diagnostic ascites tap with analysis of polymorphonuclear leukocytes in the ascites fluid. The patients had initially been questioned about background factors and physically examined according to a standardized case record form. Samples of blood, urine, and ascites were then drawn for analysis according to a structured schedule. Results: SBP could be excluded in 80% of all the cases and was confirmed in 8% of the 133 patients in the final analysis. Abdominal pain and abdominal tenderness were more common in patients with SBP (p < 0.01), but no other physical sign or laboratory test could separate SBP cases from the others. Conclusions: SBP was present in about one-tenth of the hospitalized patients with cirrhotic ascites in this cohort. Performing repeated physical examinations and paying particular attention to abdominal tenderness may be the best way to become aware of the possible development of this complication.
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| 26. |
- Ahn, Sang-Hoon, et al.
(författare)
-
The Politics of Old Age in Sweden
- 1999
-
Ingår i: The Politic of Old Age in Europe. - : Buckingham: Open University Press.
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 27. |
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| 28. |
- Alfonsson, Sven, et al.
(författare)
-
Is online treatment adherence affected by presentation and therapist support? : A randomized controlled trial
- 2016
-
Ingår i: Computers in human behavior. - : Elsevier BV. - 0747-5632 .- 1873-7692. ; 60, s. 550-558
-
Tidskriftsartikel (refereegranskat)abstract
- In both face to face and Internet based Cognitive Behavior Therapy, patients' adherence can be improved by different means such as by using motivational techniques or automatic reminders. The main aim of this study was to investigate whether enriched treatment material presentation and/or increased frequency and quality of support would increase participants' adherence to an online relaxation program. One hundred and sixty-two participants with mild to moderate symptoms of stress or worry were included in this study. Participants were randomized to either Normal or Enhanced intervention presentation and Normal or Enhanced support in a full factorial design. Main outcome variables were progress through the online intervention and adherence to prescribed exercises. Participants in the Enhanced support group progressed further through the program than participants in the Normal support group (Z = 2.11, p = .035, r = .17) but there were no significant differences found between the Normal and Enhanced presentation groups. Participants registered a mean of 60% of the prescribed exercises with no significant differences between groups. This study shows that adherence to online interventions can be increased by increased frequency and quality of therapeutic contact. Future studies may investigate how to increase adherence to prescribed homework assignments and whether parts of the therapeutic support may be substituted with automatic systems with retained effects.
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| 29. |
- Alfonsson, Sven, et al.
(författare)
-
Motivation and Treatment Credibility Predicts Dropout, Treatment Adherence, and Clinical Outcomes in an Internet-Based Cognitive Behavioral Relaxation Program : A Randomized Controlled Trial.
- 2016
-
Ingår i: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 18:3
-
Tidskriftsartikel (refereegranskat)abstract
- Background: In previous research, variables such as age, education, treatment credibility, and therapeutic alliance have shown to affect patients' treatment adherence and outcome in Internet-based psychotherapy. A more detailed understanding of how such variables are associated with different measures of adherence and clinical outcomes may help in designing more effective online therapy.Objective: The aims of this study were to investigate demographical, psychological, and treatment-specific variables that could predict dropout, treatment adherence, and treatment outcomes in a study of online relaxation for mild to moderate stress symptoms.Methods: Participant dropout and attrition as well as data from self-report instruments completed before, during, and after the online relaxation program were analyzed. Multiple linear and logistical regression analyses were conducted to predict early dropout, overall attrition, online treatment progress, number of registered relaxation exercises, posttreatment symptom levels, and reliable improvement.Results: Dropout was significantly predicted by treatment credibility, whereas overall attrition was associated with reporting a focus on immediate consequences and experiencing a low level of intrinsic motivation for the treatment. Treatment progress was predicted by education level and treatment credibility, whereas number of registered relaxation exercises was associated with experiencing intrinsic motivation for the treatment. Posttreatment stress symptoms were positively predicted by feeling external pressure to participate in the treatment and negatively predicted by treatment credibility. Reporting reliable symptom improvement after treatment was predicted by treatment credibility and therapeutic bond.Conclusions: This study confirmed that treatment credibility and a good working alliance are factors associated with successful Internet-based psychotherapy. Further, the study showed that measuring adherence in different ways provides somewhat different results, which underscore the importance of carefully defining treatment adherence in psychotherapy research. Lastly, the results suggest that finding the treatment interesting and engaging may help patients carry through with the intervention and complete prescribed assignments, a result that may help guide the design of future interventions.
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| 30. |
- Alfonsson, Sven, et al.
(författare)
-
Socio-demographic and clinical variables associated with psychological distress one and three years after a breast cancer diagnosis
- 2016
-
Ingår i: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339. ; 24:9, s. 4017-4023
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: A large group of women (20-30%) report psychological distress shortly after breast cancer diagnosis, and some experience continued or increased symptoms over time. The aim of this study was to investigate socio-demographic and clinical variables associated with sustained psychological distress in this patient group. METHODS: Women with breast cancer (n=833) completed self-report questionnaires regarding socio-demographic and clinical variables shortly after (T1) and 3years after diagnosis (T2) while data on illness severity were collected from a quality register. The Hospital Anxiety and Depression Scale was used as a measure of psychological distress at both time points. RESULTS: The number of participants who reported elevated levels of anxiety was 231 (28%) at T1 and 231 (28%) at T2 while elevated depressive symptoms was reported by 119 (14%) women at T1 and 92 (11%) at T2. Despite non-significant differences in mean scores over time, 91 (15%) participants reported increased anxiety symptoms and 47 (7%) reported increased depressive symptoms. Poor financial situation, lack of social support, previous psychiatric treatment, and high levels of fatigue were associated with both anxiety and depressive symptoms. Reporting high levels of fatigue was the variable most strongly associated with increased psychological distress over time. CONCLUSION: Most participants reported decreased psychological distress over time, but there were subgroups of women who experienced sustained or increased symptoms of anxiety or depression. Participants with poor financial status, previous psychological problems, or high levels of fatigue may be at increased risk of psychological distress. Such individuals may benefit most from psychosocial interventions.
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| 31. |
- Alfonsson, Sven, et al.
(författare)
-
The effects of therapist support and treatment presentation on the clinical outcomes of an Internet based applied relaxation program
- 2015
-
Ingår i: Internet Interventions. - : Elsevier BV. - 2214-7829. ; 2:3, s. 289-296
-
Tidskriftsartikel (refereegranskat)abstract
- Symptoms of stress are common in the general population and associated with health risks and economic costs. Applied relaxation training has shown to be effective for reducing stress and worry both as a self-help treatment and as an internet-based intervention with therapist support. However, what factors may affect the outcome of internet based relaxation training is unclear. The aims of the present study were to investigate the effect of a brief internet based relaxation program for people with symptoms of stress or worry and to assess whether enhancing the quality of intervention presentation or therapist support had an impact on outcomes.Participants were randomized in a full factorial design to either Normal or Enhanced treatment Presentation and either Normal or Enhanced therapist Support in a four-week online program with applied relaxation. The main outcome measures were self-report instruments of stress and worry.A total of 162 participants were included in the study and 94 and 84 participants completed the post and follow-up measurements respectively. Participants in all conditions improved significantly on the main outcome measures, and the different levels of Presentation or therapist Support did not significantly affect treatment outcome. Registered number of completed exercises was a predictor of better treatment outcome, but this effect was independent of treatment condition. Enhancing internet based interventions by improving presentations and the quality of support may thus not be the best way to further improve the effect of internet based interventions. More specific knowledge of the mechanisms that affect outcomes in online psychotherapy is needed.
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| 32. |
- Altman, Daniel, et al.
(författare)
-
Anal sphincter lacerations and upright delivery postures - a risk analysis from a randomized controlled trial
- 2007
-
Ingår i: International Urogynecology Journal. - : Springer Science and Business Media LLC. - 0937-3462 .- 1433-3023. ; 18:2, s. 141-146
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate obstetric sphincter lacerations after a kneeling or sitting position at second stage of labor in a multivariate risk analysis model. MATERIALS AND METHODS: Two hundred and seventy-one primiparous women with normal pregnancies and spontaneous labor were randomized, 138 to a kneeling position and 133 to a sitting position. Medical data were retrieved from delivery charts and partograms. Risk factors were tested in a multivariate logistic regression model in a stepwise manner. RESULTS: The trial was completed by 106 subjects in the kneeling group and 112 subjects in the sitting group. There were no significant differences with regard to duration of second stage of labor or pre-trial maternal characteristics between the two groups. Obstetrical sphincter tears did not differ significantly between the two groups but an intact perineum was more common in the kneeling group (p<0.03) and episiotomy (mediolateral) was more common in the sitting group (p<0.05). Three grade IV sphincter lacerations occurred in the sitting group compared to none in the kneeling group (NS). Multivariate risk analysis indicated that prolonged duration of second stage of labor and episiotomy were associated with an increased risk of third- or fourth-degree sphincter tears (p<0.01 and p<0.05, respectively). Delivery posture, maternal age, fetal weight, use of oxytocin, and use of epidural analgesia did not increase the risk of obstetrical anal sphincter lacerations in the two upright postures. CONCLUSION: Obstetrical anal sphincter lacerations did not differ significantly between a kneeling or sitting upright delivery posture. Episiotomy was more common after a sitting delivery posture, which may be associated with an increased risk of anal sphincter lacerations. Upright delivery postures may be encouraged in healthy women with normal, full-term pregnancy.
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| 33. |
- Ambrosi, Aurelie, et al.
(författare)
-
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
- 2012
-
Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 71:3, s. 334-340
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. less thanbrgreater than less thanbrgreater thanMethods The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. less thanbrgreater than less thanbrgreater thanResults There was a recurrence rate of 12.1% in Ro/La-positive women, and no recurrence in Ro/La-negative women. Fetal gender and parity did not influence the development of heart block in either group. Maternal age in Ro/La-positive pregnancies with a child affected by heart block was, however, significantly higher than in pregnancies resulting in babies without heart block (pandlt;0.05). Seasonal timing of pregnancy influenced the outcome. Gestational susceptibility weeks 18-24 occurring during January-March correlated with a higher proportion of children with heart block and lower vitamin D levels during the same period in a representative sample of Swedish women and a corresponding higher proportion of children with heart block born in the summer (pandlt;0.02). Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. less thanbrgreater than less thanbrgreater thanConclusion This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. These observations may be useful for counselling when pregnancy is considered.
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| 34. |
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| 35. |
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| 36. |
- Annerbrink, Kristina, 1974, et al.
(författare)
-
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: A replication
- 2010
-
Ingår i: Psychiatry Research. - : Elsevier Science B.V., Amsterdam.. - 0165-1781 .- 1872-7123. ; 178:1, s. 196-198
-
Tidskriftsartikel (refereegranskat)abstract
- The association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder was studied in a Swedish sample of 211 patients and 452 controls. We found a significant excess of the Val allele in both male and female patients, the latter but not the former finding being in line with previous studies.
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| 37. |
- Annerbrink, Kristina, 1974, et al.
(författare)
-
Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene
- 2011
-
Ingår i: PSYCHIATRIC GENETICS. - : Rapid Communications of Oxford Ltd. - 0955-8829 .- 1473-5873. ; 21:2, s. 85-89
-
Tidskriftsartikel (refereegranskat)abstract
- Background Orexin A and B are neuropeptides influencing, for example, arousal and respiration. Although panic disorder is characterized by both enhanced proneness for arousal and by respiratory abnormalities, the possible influence of orexin-related genes on the risk of developing this disorder has not been studied until now. Methods We have analyzed the Ile408Val polymorphism in the hypocretin receptor 1 (HCRTR1) gene and the Val308Iso (G1246A) polymorphism in the hypocretin receptor 2 (HCRTR2) gene in a sample of 215 panic disorder patients and 454 controls. Results Although the polymorphism in the HCRTR1 did not differ between groups, the Iso allele of the HCRTR2 polymorphism was significantly more frequent in patients than in controls. After the population was divided according to sex, the association between the Iso allele of the Val308Iso polymorphism and panic disorder was observed only in female patients. Conclusion Our results suggest that the HCRTR2 polymorphism may be of importance for the pathophysiology of panic disorder. The results should be regarded as preliminary until replicated in an independent sample. This indicates that further research on the possible role of orexin in panic disorder may prove rewarding.
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| 38. |
- Anrup, Roland, et al.
(författare)
-
Centrala universitetsvärden hotas av bolagiseringsidén
- 2013
-
Ingår i: Dagens nyheter. - 1101-2447.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Högskolestiftelser. Förslaget att driva svenska universitet i stiftelseform öppnar för bolagisering. Men det är ingen riktig utredning, utan en politisk pamflett utan eftertanke. Privatisering av universitet hotar både oberoendet, forskningskvaliteten och samhällsnyttan, skriver 36 forskare vid svenska högskolor och universitet.
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| 39. |
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| 40. |
- Arkitektur & teknik 2020/21, Årskurs 3, et al.
(författare)
-
Resedagbok Schweiz augusti 2021
- 2021
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Arkitektur och tekniks årliga studieresa till Schweiz är på många sätt unik. Vi transporterar oss själva genom det vackra alplandskapet och besöker några av landets vackraste broar och byggnader. De vilda bergsmassiven och den förfinade byggnadskulturen väver sig in i varandra under hela vår magiska arkitektursafari. Resan i augusti 2021 blev nästan ett år försenad på grund av pandemin. I stället för en förberedelse av studierna i årskurs 3 blev det en festlig avslutning på kandidattiden på Chalmers. Vid sidan om våra gängse besöksmål, från Robert Maillarts och Jürg Conzetts konstruktioner till Le Corbusier och Peter Zumthors arkitektur, hade vi den här resan ett särskilt fokus på materialen lera, kalk, sten och cement, och på restaurering av broar och byggnader i dessa material.
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| 41. |
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| 42. |
- Axsäter, Sven, et al.
(författare)
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Heuristics for Handling Direct Upstream Demand in Two-Echelon Distribution Inventory Systems
- 2007
-
Ingår i: International Journal of Production Economics. - : Elsevier BV. - 0925-5273. ; 108:1-2, s. 266-270
-
Tidskriftsartikel (refereegranskat)abstract
- This paper considers a two-echelon distribution inventory system with a central warehouse and a number of retailers. There is direct customer demand also at the warehouse. If this upstream demand requires a high service, it may be advantageous to give higher priority to customer orders compared to retailer replenishments. We suggest and evaluate techniques for handling this situation. One technique means that we have an extra separate stock point for the direct customer demand at the warehouse. Another technique means that we apply a so-called critical level policy at the warehouse, i.e., if the stock on hand at the warehouse is less than or equal to the critical level, retailer replenishments are backordered.
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| 43. |
- Baison, J., et al.
(författare)
-
Genetic control of tracheid properties in Norway spruce wood
- 2020
-
Ingår i: Scientific Reports. - : Nature Research. - 2045-2322. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- Through the use of genome-wide association studies (GWAS) mapping it is possible to establish the genetic basis of phenotypic trait variation. Our GWAS study presents the first such effort in Norway spruce (Picea abies (L). Karst.) for the traits related to wood tracheid characteristics. The study employed an exome capture genotyping approach that generated 178 101 Single Nucleotide Polymorphisms (SNPs) from 40 018 probes within a population of 517 Norway spruce mother trees. We applied a least absolute shrinkage and selection operator (LASSO) based association mapping method using a functional multi-locus mapping approach, with a stability selection probability method as the hypothesis testing approach to determine significant Quantitative Trait Loci (QTLs). The analysis has provided 30 significant associations, the majority of which show specific expression in wood-forming tissues or high ubiquitous expression, potentially controlling tracheids dimensions, their cell wall thickness and microfibril angle. Among the most promising candidates based on our results and prior information for other species are: Picea abies BIG GRAIN 2 (PabBG2) with a predicted function in auxin transport and sensitivity, and MA_373300g0010 encoding a protein similar to wall-associated receptor kinases, which were both associated with cell wall thickness. The results demonstrate feasibility of GWAS to identify novel candidate genes controlling industrially-relevant tracheid traits in Norway spruce. © 2020, The Author(s).
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| 44. |
- Baison, John, et al.
(författare)
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Genome-Wide Association Study (GWAS) identified novel candidate loci affecting wood formation in Norway spruce
- 2019
-
Ingår i: The Plant Journal. - : Wiley. - 0960-7412 .- 1365-313X. ; 100:1, s. 83-100
-
Tidskriftsartikel (refereegranskat)abstract
- Norway spruce is a boreal forest tree species of significant ecological and economic importance. Hence there is a strong imperative to dissect the genetics underlying important wood quality traits in the species. We performed a functional Genome-Wide Association Study (GWAS) of 17 wood traits in Norway spruce using 178101 single-nucleotide polymorphisms (SNPs) generated from exome genotyping of 517 mother trees. The wood traits were defined using functional modelling of wood properties across annual growth rings.We applied a LASSO based association mapping method using a functional multi-locus mapping approach that utilizes latent traits, with a stability selection probability method as the hypothesis testing approach to determine significant Quantitative Trait Loci (QTLs). The analysis provided 52 significant SNPs from 39 candidate genes, including genes previously implicated in wood formation and tree growth in spruce and other species. Our study represents a multi-locus GWAS for complex wood traits in Norway spruce. The results advance our understanding of the genetics influencing wood traits and identifies candidate genes for future functional studies.
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| 45. |
- Baison, John, et al.
(författare)
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Genome-wide association study identified novel candidate loci affecting wood formation in Norway spruce
- 2019
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Ingår i: The Plant Journal. - : John Wiley & Sons. - 0960-7412 .- 1365-313X. ; 100:1, s. 83-100
-
Tidskriftsartikel (refereegranskat)abstract
- Norway spruce is a boreal forest tree species of significant ecological and economic importance. Hence there is a strong imperative to dissect the genetics underlying important wood quality traits in the species. We performed a functional genome-wide association study (GWAS) of 17 wood traits in Norway spruce using 178 101 single nucleotide polymorphisms (SNPs) generated from exome genotyping of 517 mother trees. The wood traits were defined using functional modelling of wood properties across annual growth rings. We applied a Least Absolute Shrinkage and Selection Operator (LASSO-based) association mapping method using a functional multilocus mapping approach that utilizes latent traits, with a stability selection probability method as the hypothesis testing approach to determine a significant quantitative trait locus. The analysis provided 52 significant SNPs from 39 candidate genes, including genes previously implicated in wood formation and tree growth in spruce and other species. Our study represents a multilocus GWAS for complex wood traits in Norway spruce. The results advance our understanding of the genetics influencing wood traits and identifies candidate genes for future functional studies.
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| 46. |
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| 47. |
- Bergman, Paavo, 1945-, et al.
(författare)
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Arbete och fritid
- 1977. - 1
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Ingår i: Bingospelare. - Stockholm : Tidens förlag. - 9155021840 ; , s. 32-40
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 48. |
- Bergman, Paavo, 1945-, et al.
(författare)
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Bingo en pestsmitta?
- 1977. - 1
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Ingår i: Bingospelare. - Stockholm : Tidens förlag. - 9155021840 ; , s. 26-31
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 49. |
- Bergman, Paavo, 1945-, et al.
(författare)
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Bingo och social stratifiering
- 1977. - 1
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Ingår i: Bingospelare. - Stockholm : Tidens förlag. - 9155021840 ; , s. 63-79
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 50. |
- Bergman, Paavo, 1945-, et al.
(författare)
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Umgänge och psykisk kondition
- 1977. - 1
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Ingår i: Bingospelare. - Stockholm : Tidens förlag. - 9155021840 ; , s. 80-89
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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