| 1. |
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| 2. |
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| 3. |
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| 4. |
- Li, W, et al.
(författare)
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Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL
- 2020
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 6:1, s. 63-
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Tidskriftsartikel (refereegranskat)abstract
- Dynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). The purpose of this retrospective study is to test if prediction models combining multiple MRI features outperform models with single features. Four features were quantitatively calculated in each MRI exam: functional tumor volume, longest diameter, sphericity, and contralateral background parenchymal enhancement. Logistic regression analysis was used to study the relationship between MRI variables and pathologic complete response (pCR). Predictive performance was estimated using the area under the receiver operating characteristic curve (AUC). The full cohort was stratified by hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status (positive or negative). A total of 384 patients (median age: 49 y/o) were included. Results showed analysis with combined features achieved higher AUCs than analysis with any feature alone. AUCs estimated for the combined versus highest AUCs among single features were 0.81 (95% confidence interval [CI]: 0.76, 0.86) versus 0.79 (95% CI: 0.73, 0.85) in the full cohort, 0.83 (95% CI: 0.77, 0.92) versus 0.73 (95% CI: 0.61, 0.84) in HR-positive/HER2-negative, 0.88 (95% CI: 0.79, 0.97) versus 0.78 (95% CI: 0.63, 0.89) in HR-positive/HER2-positive, 0.83 (95% CI not available) versus 0.75 (95% CI: 0.46, 0.81) in HR-negative/HER2-positive, and 0.82 (95% CI: 0.74, 0.91) versus 0.75 (95% CI: 0.64, 0.83) in triple negatives. Multi-feature MRI analysis improved pCR prediction over analysis of any individual feature that we examined. Additionally, the improvements in prediction were more notable when analysis was conducted according to cancer subtype.
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| 5. |
- Schjesvold, F., et al.
(författare)
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Cobimetinib Alone and Plus Venetoclax With/Without Atezolizumab in Patients With Relapsed/Refractory Multiple Myeloma
- 2023
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Ingår i: Clinical Lymphoma, Myeloma and Leukemia. - : Elsevier BV. - 2152-2650. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Mitogen-activated protein kinase pathway mutations are present in >50% of patients with relapsed/refractory (R/R) multiple myeloma (MM). MEK inhibitors show limited single-agent activity in R/R MM; combination with B-cell lymphoma-2 (BCL-2) and programmed death-ligand 1 inhibition may improve efficacy. This phase Ib/II trial (NCT03312530) evaluated safety and efficacy of cobimetinib (cobi) alone and in combination with venetoclax (ven) with/without atezolizumab (atezo) in patients with R/R MM. Patients and Methods: Forty-nine patients were randomized 1:2:2 to cobi 60 mg/day on days 1–21 (n = 6), cobi 40 mg/day on days 1–21 + ven 800 mg/day on days 1–28 with/without atezo 840 mg on days 1 and 15 of 28-day cycles (cobi-ven, n = 22; cobi-ven-atezo, n = 21). Safety run-in cohorts evaluated cobi-ven and cobi-ven-atezo dose levels. Results: Any-grade common adverse events (AEs) with cobi, cobi-ven, and cobi-ven-atezo, respectively, included diarrhea (33.3%, 81.8%, 90.5%) and nausea (16.7%, 50.0%, 66.7%); common grade ≥3 AEs included anemia (0%, 22.7%, 23.8%), neutropenia (0%, 13.6%, 38.1%), and thrombocytopenia (0%, 18.2%, 23.8%). The overall response rate for all-comers was 0% (cobi), 27.3% (cobi-ven), and 28.6% (cobi-ven-atezo), and 0%, 50.0%, and 100%, respectively, in patients with t(11;14)+. Biomarker analysis demonstrated non-t(11;14) patient selection with NRAS/KRAS/BRAF mutation or high BCL-2/BCL-2-L1 ratio (>52% of the study population) could enrich for responders to the cobi-ven combination. Conclusions: Cobi-ven and cobi-ven-atezo demonstrated manageable safety with moderate activity in all-comers, and higher activity in patients with t(11;14)+ MM, supporting a biomarker-driven approach for ven in MM.
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| 6. |
- De La Fuente, Eduardo, et al.
(författare)
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Detection of a new molecular cloud in the LHAASO J2108+5157 region supporting a hadronic PeVatron scenario
- 2023
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Ingår i: Publication of the Astronomical Society of Japan. - 2053-051X .- 0004-6264. ; 75:3, s. 546-566
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Tidskriftsartikel (refereegranskat)abstract
- PeVatrons are the most powerful naturally occurring particle accelerators in the Universe. The identification of counterparts associated to astrophysical objects such as dying massive stars, molecular gas, star-forming regions, and star clusters is essential to clarify the underlying nature of the PeV emission, i.e., hadronic or leptonic. We present 12,13CO (J = 2→1) observations made with the 1.85 m radio-Telescope of the Osaka Prefecture University toward the Cygnus OB7 molecular cloud, which contains the PeVatron candidate LHAASO J2108+5157. We investigate the nature of the sub-PeV (gamma-ray) emission by studying the nucleon density determined from the content of H i and H2, derived from the CO observations. In addition to MML[2017]4607, detected via the observations of the optically thick 12CO (J = 1→0) emission, we infer the presence of an optically thin molecular cloud, named [FKT-MC]2022, whose angular size is 1-1 ± 0.}^\circ}}2. We propose this cloud as a new candidate to produce the sub-PeV emission observed in LHAASO J2108+5157. Considering a distance of 1.7 kpc, we estimate a nucleon (H i + H2) density of 37 ± 14 cm-3, and a total nucleon mass(H i + H2) of 1.5 ± 0.6 × 104 M·. On the other hand, we confirm that Kronberger 82 is a molecular clump with an angular size of 0°1, a nucleon density ∼103 cm-3, and a mass ∼103 M·. Although Kronberger 82 hosts the physical conditions to produce the observed emission of LHAASO J2108+5157, [FKT-MC]2022 is located closer to it, suggesting that the latter could be the one associated to the sub-PeV emission. Under this scenario, our results favour a hadronic origin for the emission.
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| 7. |
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| 8. |
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| 9. |
- Falstad, Niklas, 1987, et al.
(författare)
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CON-quest: Searching for the most obscured galaxy nuclei
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 649
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Tidskriftsartikel (refereegranskat)abstract
- Context. Some luminous and ultraluminous infrared galaxies (LIRGs and ULIRGs) host extremely compact (r < 100 pc) and dusty nuclei. The high extinction associated with large column densities of gas and dust toward these objects render them hard to detect at many wavelengths. The intense infrared radiation arising from warm dust in these sources can provide a significant fraction of the bolometric luminosity of the galaxy and is prone to excite vibrational levels of molecules such as HCN. This results in emission from the rotational transitions of vibrationally excited HCN (HCN-vib); the brightest emission is found in compact obscured nuclei (CONs; ςHCN-vib > 1 L⊙ pc-2 in the J = 3-2 transition). However, there have been no systematic searches for CONs, and it is unknown how common they are. Aims. We aim to establish how common CONs are in the local Universe (z < 0.08), and whether their prevalence depends on the luminosity or other properties of the host galaxy. Methods. We conducted an Atacama Large Millimeter/submillimeter Array survey of the rotational J = 3-2 transition of HCN-vib in a volume-limited sample of 46 far-infrared luminous galaxies. Results. Compact obscured nuclei are identified in 38-13+18% of the ULIRGs, 21-6+12% of the LIRGs, and 0-0+9% of the lower luminosity galaxies. We find no dependence on the inclination of the host galaxy, but strong evidence of lower IRAS 25 μm to 60 μm flux density ratios (f25/f60) in CONs (with the exception of one galaxy, NGC 4418) compared to the rest of the sample. Furthermore, we find that CONs have stronger silicate features (s9.7 μm), but similar polycyclic aromatic hydrocarbon equivalent widths (EQW6.2 μm) compared to other galaxies. Along with signatures of molecular inflows seen in the far-infrared in most CONs, submillimeter observations also reveal compact, often collimated, outflows. Conclusions. In the local Universe, CONs are primarily found in (U)LIRGs, in which they are remarkably common. As such systems are often highly disturbed, inclinations are difficult to estimate, and high-resolution continuum observations of the individual nuclei are required to determine if the CON phenomenon is related to the inclinations of the nuclear disks. Further studies of the in- A nd outflow properties of CONs should also be conducted to investigate how these are connected to each other and to the CON phenomenon. The lower f25/f60 ratios in CONs as well as the results for the mid-infrared diagnostics investigated (EQW6.2 μm and s9.7 μm) are consistent with the notion that large dust columns gradually shift the radiation from the hot nucleus to longer wavelengths, making the mid- A nd far-infrared "photospheres"significantly cooler than the interior regions. Finally, to assess the importance of CONs in the context of galaxy evolution, it is necessary to extend this study to higher redshifts where (U)LIRGs are more common.
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| 10. |
- Flood, Victoria A., et al.
(författare)
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Evaluating modelled tropospheric columns of CH4, CO, and O3 in the Arctic using ground-based Fourier transform infrared (FTIR) measurements
- 2024
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Ingår i: Atmospheric Chemistry and Physics. - 1680-7316 .- 1680-7324. ; 24:2, s. 1079-1118
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Tidskriftsartikel (refereegranskat)abstract
- This study evaluates tropospheric columns of methane, carbon monoxide, and ozone in the Arctic simulated by 11 models. The Arctic is warming at nearly 4 times the global average rate, and with changing emissions in and near the region, it is important to understand Arctic atmospheric composition and how it is changing. Both measurements and modelling of air pollution in the Arctic are difficult, making model validation with local measurements valuable. Evaluations are performed using data from five high-latitude ground-based Fourier transform infrared (FTIR) spectrometers in the Network for the Detection of Atmospheric Composition Change (NDACC). The models were selected as part of the 2021 Arctic Monitoring and Assessment Programme (AMAP) report on short-lived climate forcers. This work augments the model-measurement comparisons presented in that report by including a new data source: column-integrated FTIR measurements, whose spatial and temporal footprint is more representative of the free troposphere than in situ and satellite measurements. Mixing ratios of trace gases are modelled at 3-hourly intervals by CESM, CMAM, DEHM, EMEP MSC-W, GEM-MACH, GEOS-Chem, MATCH, MATCH-SALSA, MRI-ESM2, UKESM1, and WRF-Chem for the years 2008, 2009, 2014, and 2015. The comparisons focus on the troposphere (0-7km partial columns) at Eureka, Canada; Thule, Greenland; Ny Ålesund, Norway; Kiruna, Sweden; and Harestua, Norway. Overall, the models are biased low in the tropospheric column, on average by -9.7% for CH4, -21% for CO, and -18% for O3. Results for CH4 are relatively consistent across the 4 years, whereas CO has a maximum negative bias in the spring and minimum in the summer and O3 has a maximum difference centered around the summer. The average differences for the models are within the FTIR uncertainties for approximately 15% of the model-location comparisons.
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| 11. |
- Gorski, Mark, 1989, et al.
(författare)
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A spectacular galactic scale magnetohydrodynamic powered wind in ESO 320-G030
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 684
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Tidskriftsartikel (refereegranskat)abstract
- How galaxies regulate nuclear growth through gas accretion by supermassive black holes (SMBHs) is one of the most fundamental questions in galaxy evolution. One potential way to regulate nuclear growth is through a galactic wind that removes gas from the nucleus. It is unclear whether galactic winds are powered by jets, mechanical winds, radiation, or via magnetohydrodynamic (MHD) processes. Compact obscured nuclei represent a significant phase of galactic nuclear growth. These galaxies hide growing SMBHs or unusual starbursts in their very opaque, extremely compact (r < 100 pc) centres. They are found in approximately 30% of the luminous and ultra-luminous infrared galaxy population. Here, we present high-resolution ALMA observations (∼30 mas, ∼5 pc) of ground-state and vibrationally excited HCN towards ESO 320-G030 (IRAS 11506-3851). ESO 320-G030 is an isolated luminous infrared galaxy known to host a compact obscured nucleus and a kiloparsec-scale molecular wind. Our analysis of these high-resolution observations excludes the possibility of a starburst-driven wind, a mechanically or energy driven active galactic nucleus wind, and exposes a molecular MDH wind. These results imply that the nuclear evolution of galaxies and the growth of SMBHs are similar to the growth of hot cores or protostars where gravitational collapse of the nuclear torus drives a MHD wind. These results mean galaxies are capable, in part, of regulating the evolution of their nuclei without feedback.
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| 12. |
- Izumi, T., et al.
(författare)
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On the Disappearance of a Cold Molecular Torus around the Low-luminosity Active Galactic Nucleus of NGC 1097
- 2017
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 845:1, s. L5-
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Tidskriftsartikel (refereegranskat)abstract
- We used the Atacama Large Millimeter/Submillimeter Array to map the CO(3-2) and the underlying continuum emissions around the type-1low-luminosity active galactic nucleus (LLAGN; bolometric luminosity less than or similar to 10(42) erg. s(-1)) of NGC 1097 at similar to 10 pc resolution. These observations revealed a detailed cold gas distribution within a similar to 100 pc of this LLAGN. In contrast to the luminous Seyfert galaxy NGC 1068, where a similar to 7 pc cold molecular torus was recently revealed, a distinctively dense and compact torus is missing in our CO(3-2) integrated intensity map of NGC 1097. Based on the CO(3-2) flux, the gas mass of the torus of NGC 1097 would be a factor of greater than or similar to 2-3 less than that found for NGC 1068 by using the same CO-to-H-2 conversion factor, which implies less active nuclear star formation and/or inflows in NGC 1097. Our dynamical modeling of the CO(3-2) velocity field implies that the cold molecular gas is concentrated in a thin layer as compared to the hot gas traced by the 2.12 mu m H-2 emission in and around the torus. Furthermore, we suggest that NGC 1097 hosts a geometrically thinner torus than NGC 1068. Although the physical origin of the torus thickness remains unclear, our observations support a theoretical prediction that geometrically thick tori with high opacity will become deficient as AGNs evolve from luminous Seyferts to LLAGNs.
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| 13. |
- Nagai, H., et al.
(författare)
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The ALMA Discovery of the Rotating Disk and Fast Outflow of Cold Molecular Gas in NGC 1275
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 883:2
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Tidskriftsartikel (refereegranskat)abstract
- We present observations using the Atacama Large Millimeter/submillimeter Array of the CO(2-1), HCN(3-2), and HCO+(3-2) lines in the nearby radio galaxy/brightest cluster galaxy (BCG) NGC 1275 with a spatial resolution of similar to 20 pc. In previous observations, the CO(2-1) emission was detected as radial filaments lying in the east west direction on a kiloparsec scale. We resolved the inner filament and found that it cannot be represented by a simple infalling stream on a sub-kiloparsec scale. The observed complex nature of the filament resembles the cold gas structure predicted by numerical simulations of cold chaotic accretion. Within the central 100 pc, we detected a rotational disk of molecular gas whose mass is similar to 10(8) M-circle dot. This is the first evidence of the presence of a massive cold gas disk on this spatial scale for BCGs. A crude estimate suggests that the accretion rate of the cold gas can be higher than that of hot gas. The disk rotation axis is approximately consistent with the radio-jet axis. This probably suggests that the cold gas disk is physically connected to the innermost accretion disk, which is responsible for jet launching. We also detected absorption features in the HCN(3-2) and HCO+(3-2) spectra against the radio continuum emission mostly radiated by a jet of size similar to 1.2 pc. The absorption features are blueshifted from the systemic velocity by similar to 300-600 km s(-1), suggesting the presence of outflowing gas from the active galactic nucleus (AGN). We discuss the relation of the AGN feeding with cold accretion, the origin of blueshifted absorption, and an estimate of the black hole mass using molecular gas dynamics.
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| 14. |
- Nishimura, Y., et al.
(författare)
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CON-quest: II. Spatially and spectrally resolved HCN/HCO + line ratios in local luminous and ultraluminous infrared galaxies
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 686
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Tidskriftsartikel (refereegranskat)abstract
- Context. Nuclear regions of ultraluminous and luminous infrared galaxies (U/LIRGs) are powered by starbursts and/or active galactic nuclei (AGNs). These regions are often obscured by extremely high columns of gas and dust. Molecular lines in the submillimeter windows have the potential to determine the physical conditions of these compact obscured nuclei (CONs). Aims. We aim to reveal the distributions of HCN and HCO+ emission in local U/LIRGs and investigate whether and how they are related to galaxy properties. Methods. Using the Atacama Large Millimeter/submillimeter Array (ALMA), we have conducted sensitive observations of the HCN J = 3-2 and HCO+J = 3-2 lines toward 23 U/LIRGs in the local Universe (z < 0.07) with a spatial resolution of ~0.3″ ( ~50-400 pc). Results. We detected both HCN and HCO+ in 21 galaxies, only HCN in one galaxy, and neither in one galaxy. The global HCN/HCO+ line ratios, averaged over scales of ~0.5-4 kpc, range from 0.4 to 2.3, with an unweighted mean of 1.1. These line ratios appear to have no systematic trend with bolometric AGN luminosity or star formation rate. The line ratio varies with position and velocity within each galaxy, with an average interquartile range of 0.38 on a spaxel-by-spaxel basis. In eight out of ten galaxies known to have outflows and/or inflows, we found spatially and kinematically symmetric structures of high line ratios. These structures appear as a collimated bicone in two galaxies and as a thin spherical shell in six galaxies. Conclusions. Non-LTE analysis suggests that the high HCN/HCO+ line ratio in outflows is predominantly influenced by the abundance ratio. Chemical model calculations indicate that the enhancement of HCN abundance in outflows is likely due to high-temperature chemistry triggered by shock heating. These results imply that the HCN/HCO+ line ratio can aid in identifying the outflow geometry when the shock velocity of the outflows is sufficiently high to heat the gas.
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| 15. |
- North, Eve V., et al.
(författare)
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WISDOM project – V. Resolving molecular gas in Keplerian rotation around the supermassive black hole in NGC 0383
- 2019
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 490:1, s. 319-330
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Tidskriftsartikel (refereegranskat)abstract
- As part of the mm-Wave Interferometric Survey of Dark Object Masses (WISDOM), we present a measurement of the mass of the supermassive black hole (SMBH) in the nearby early-type galaxy NGC 0383 (radio source 3C 031). This measurement is based on Atacama Large Millimeter/sub-millimeter Array (ALMA) cycle 4 and 5 observations of the 12CO(2–1) emission line with a spatial resolution of 58 × 32 pc2 (0.18 arcsec × 0.1 arcsec). This resolution, combined with a channel width of 10 km s−1, allows us to well resolve the radius of the black hole sphere of influence (measured as RSOI = 316 pc = 0.98 arcsec), where we detect a clear Keplerian increase of the rotation velocities. NGC 0383 has a kinematically relaxed, smooth nuclear molecular gas disc with weak ring/spiral features. We forward model the ALMA data cube with the KINEMATIC MOLECULAR SIMULATION (KinMS) tool and a Bayesian Markov Chain Monte Carlo method to measure an SMBH mass of (4.2 ± 0.7) × 109 M, a F160W-band stellar mass-to-light ratio that varies from 2.8 ± 0.6 M/LF160W in the centre to 2.4 ± 0.3 M/LF160W at the outer edge of the disc and a molecular gas velocity dispersion of 8.3 ± 2.1 km s−1(all 3σ uncertainties). We also detect unresolved continuum emission across the full bandwidth, consistent with synchrotron emission from an active galactic nucleus. This work demonstrates that low-J CO emission can resolve gas very close to the SMBH (≈ 140 000 Schwarzschild radii) and hence that the molecular gas method is highly complimentary to megamaser observations, as it can probe the same emitting material.
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| 16. |
- Petäjä, Tuukka, et al.
(författare)
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Overview : Integrative and Comprehensive Understanding on Polar Environments (iCUPE) - concept and initial results
- 2020
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 20:14, s. 8551-8592
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Tidskriftsartikel (refereegranskat)abstract
- The role of polar regions is increasing in terms of megatrends such as globalization, new transport routes, demography, and the use of natural resources with consequent effects on regional and transported pollutant concentrations. We set up the ERA-PLANET Strand 4 project iCUPE - integrative and Comprehensive Understanding on Polar Environments to provide novel insights and observational data on global grand challenges with an Arctic focus. We utilize an integrated approach combining in situ observations, satellite remote sensing Earth observations (EOs), and multi-scale modeling to synthesize data from comprehensive long-term measurements, intensive campaigns, and satellites to deliver data products, metrics, and indicators to stakeholders concerning the environmental status, availability, and extraction of natural resources in the polar areas. The iCUPE work consists of thematic state-of-the-art research and the provision of novel data in atmospheric pollution, local sources and transboundary transport, the characterization of arctic surfaces and their changes, an assessment of the concentrations and impacts of heavy metals and persistent organic pollutants and their cycling, the quantification of emissions from natural resource extraction, and the validation and optimization of satellite Earth observation (EO) data streams. In this paper we introduce the iCUPE project and summarize initial results arising out of the integration of comprehensive in situ observations, satellite remote sensing, and multi-scale modeling in the Arctic context.
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| 17. |
- Sewiło, Marta, et al.
(författare)
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Complex Organic Molecules in Star-Forming Regions of the Magellanic Clouds
- 2019
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Ingår i: ACS Earth and Space Chemistry. - : American Chemical Society (ACS). - 2472-3452. ; 3:10, s. 2088-2109
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Forskningsöversikt (refereegranskat)abstract
- The Large and Small Magellanic Clouds (LMC and SMC), gas-rich dwarf companions of the Milky Way, are the nearest laboratories for detailed studies on the formation and survival of complex organic molecules (COMs) under metal-poor conditions. To date, only methanol, methyl formate, and dimethyl ether have been detected in these galaxies-all three toward two hot cores in the N113 star-forming region in the LMC, the only extragalactic sources exhibiting complex hot-core chemistry. We describe a small and diverse sample of the LMC and SMC sources associated with COMs or hot-core chemistry, and compare the observations to theoretical model predictions. Theoretical models accounting for the physical conditions and metallicity of hot molecular cores in the Magellanic Clouds have been able to broadly account for the existing observations, but they fail to reproduce the dimethyl ether abundance by more than an order of magnitude. We discuss future prospects for research in the field of complex chemistry in the low-metallicity environment. The detection of COMs in the Magellanic Clouds has important implications for astrobiology. The metallicity of the Magellanic Clouds is similar to that of galaxies in the earlier epochs of the universe; thus, the presence of COMs in the LMC and SMC indicates that a similar prebiotic chemistry leading to the emergence of life, as it happened on Earth, is possible in low-metallicity systems in the earlier universe.
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| 18. |
- Siva, S, et al.
(författare)
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Consensus statement from the International Radiosurgery Oncology Consortium for Kidney for primary renal cell carcinoma
- 2016
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Ingår i: Future oncology (London, England). - : Future Medicine Ltd. - 1744-8301 .- 1479-6694. ; 12:5, s. 637-645
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To provide a multi-institutional consensus document for stereotactic body radiotherapy of primary renal cell carcinoma. Materials & methods: Eight international institutions completed a 65-item survey covering patient selection, planning/treatment aspects and response evaluation. Results: All centers treat patients with pre-existing hypertension and solitary kidneys. Five institutions apply size constraints of 5–8 cm. The total planning target volume expansion is 3–10 mm. All institutions perform pretreatment imaging verification, while seven institutions perform some form of intrafractional monitoring. Number of fractions used are 1–12 to a total dose of 25 Gy–80 GyE. Imaging follow-up for local tumor response includes computed tomography (n = 8), PET-computed tomography (n = 1) and MRI (n = 5). Follow-up frequency is 3–6 months for the first 2 years and 3–12 months for subsequent 3 years. Conclusion: Key methods for safe implementation and practice for stereotactic body radiotherapy kidney have been identified and may aid standardization of treatment delivery.
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| 19. |
- Thater, Sabine, et al.
(författare)
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Cross-checking SMBH mass estimates in NGC 6958-I. Stellar dynamics from adaptive optics-assisted MUSE observations
- 2022
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 509:4, s. 5416-5436
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Tidskriftsartikel (refereegranskat)abstract
- Supermassive black hole masses (M (BH)) can dynamically be estimated with various methods and using different kinematic tracers. Different methods have only been cross-checked for a small number of galaxies and often show discrepancies. To understand these discrepancies, detailed cross-comparisons of additional galaxies are needed. We present the first part of our cross-comparison between stellar- and gas-based M-BH estimates in the nearby fast-rotating early-type galaxy NGC 6958. The measurements presented here are based on ground-layer adaptive optics-assisted Multi-Unit Spectroscopic Explorer (MUSE) science verification data at around 0."6 spatial resolution. The spatial resolution is a key ingredient for the measurement and we provide a Gaussian parametrization of the adaptive optics-assisted point spread function for various wavelengths. From the MUSE data, we extracted the stellar kinematics and constructed dynamical models. Using an axisymmetric Schwarzschild technique, we measured an M-BH of (3.6(-2.4)(+2.7)) x10(8) M-circle dot at 3 sigma significance taking kinematical and dynamical systematics (e.g. radially varying mass-to-light ratio) into account. We also added a dark halo, but our data do not allow us to constrain the dark matter fraction. Adding dark matter with an abundance matching prior results in a 25 per cent more massive black hole. Jeans anisotropic models return M-BH of (4.6(-2.7)(+2.5)) x10(8) and (8.6(-0.8)(+0.8)) x10(8) M-circle dot at 3 sigma confidence for spherical and cylindrical alignments of the velocity ellipsoid, respectively. In a follow-up study, we will compare the stellar-based M (BH) with those from cold and warm gas tracers, which will provide additional constraints for the M-BH for NGC 6958, and insights into assumptions that lead to potential systematic uncertainty.
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| 20. |
- von Salzen, Knut, et al.
(författare)
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Clean air policies are key for successfully mitigating Arctic warming
- 2022
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Ingår i: Communications Earth & Environment. - : Springer Science and Business Media LLC. - 2662-4435. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- A tighter integration of modeling frameworks for climate and air quality is urgently needed to assess the impacts of clean air policies on future Arctic and global climate. We combined a new model emulator and comprehensive emissions scenarios for air pollutants and greenhouse gases to assess climate and human health co-benefits of emissions reductions. Fossil fuel use is projected to rapidly decline in an increasingly sustainable world, resulting in far-reaching air quality benefits. Despite human health benefits, reductions in sulfur emissions in a more sustainable world could enhance Arctic warming by 0.8 °C in 2050 relative to the 1995–2014, thereby offsetting climate benefits of greenhouse gas reductions. Targeted and technically feasible emissions reduction opportunities exist for achieving simultaneous climate and human health co-benefits. It would be particularly beneficial to unlock a newly identified mitigation potential for carbon particulate matter, yielding Arctic climate benefits equivalent to those from carbon dioxide reductions by 2050.
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| 21. |
- Wethers, Clare, 1991, et al.
(författare)
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Double, double, toil, and trouble: The tails, bubbles, and knots of the local compact obscured nucleus galaxy NGC 4418
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 683
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Tidskriftsartikel (refereegranskat)abstract
- Context. Compact obscured nuclei (CONs) are an extremely obscured (NH2>1025 cm-2) class of galaxy nuclei thought to exist in 20-40 per cent of nearby (ultra-)luminous infrared galaxies While they have been proposed to represent a key phase of the active galactic nucleus (AGN) feedback cycle, the nature of these CONs -what powers them, their dynamics, and their impact on the host galaxy -remains unknown. Aims. This work analyses the galaxy-scale optical properties of the local CON NGC 4418 (z=0.00727). The key aims of the study are to understand the impact of nuclear outflows on the host galaxy and infer the power source of its CON. Through the mapping of the galaxy spectra and kinematics, we seek to identify new structures in NGC 4418 to ultimately reveal more about the CON's history, its impact on the host, and, more generally, the role CONs play in galaxy evolution. Methods. We present new, targeted integral field unit observations of the galaxy with the Multi-Unit Spectroscopic Explorer (MUSE). For the first time, we mapped the ionised and neutral gas components of the galaxy, along with their dynamical structure, to reveal several previously unknown features of the galaxy. Results. We confirm the presence of a previously postulated, blueshifted outflow along the minor axis of NGC 4418. We find this outflow to be decelerating and, for the first time, show it to extend in both directions from the nucleus. We report the discovery of two further outflow structures: a redshifted southern outflow connected to a tail of ionised gas surrounding the galaxy and a blueshifted bubble to the north. In addition to these features, we find the [OIII] emission reveals the presence of knots across the galaxy, which are consistent with regions of the galaxy that have been photoionised by an AGN. Conclusions. We identify several new features in NGC 4418, including a bubble structure, a reddened outflow, and [OIII] knot structures throughout the galaxy. We additionally confirm the presence of a bilateral blueshifted outflow along the minor axis. Based on the properties of these features, we conclude that the CON in NGC 4418 is most likely powered by AGN activity.
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