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1.	Ruuth, M., et al. (author) Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, ismodifiable, and associates with future cardiovascular deaths 2018 In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 39:27 Journal article (peer-reviewed)abstract Aims Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive this disease, but LDL quality may also contribute. Here, we focused on the intrinsic propensity of LDL to aggregate upon modification. We examined whether inter-individual differences in this quality are linked with LDL lipid composition and coronary artery disease (CAD) death, and basic mechanisms for plaque growth and destabilization. Methods and results We developed a novel, reproducible method to assess the susceptibility of LDL particles to aggregate during lipolysis induced ex vivo by human recombinant secretory sphingomyelinase. Among patients with an established CAD, we found that the presence of aggregation-prone LDL was predictive of future cardiovascular deaths, independently of conventional risk factors. Aggregation-prone LDL contained more sphingolipids and less phosphatidylcholines than did aggregation-resistant LDL. Three interventions in animal models to rationally alter LDL composition lowered its susceptibility to aggregate and slowed atherosclerosis. Similar compositional changes induced in humans by PCSK9 inhibition or healthy diet also lowered LDL aggregation susceptibility. Aggregated LDL in vitro activated macrophages and T cells, two key cell types involved in plaque progression and rupture. Conclusion Our results identify the susceptibility of LDL to aggregate as a novel measurable and modifiable factor in the progression of human ASCVD.
2.	Back, M, et al. (author) Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities 2019 In: Nature reviews. Cardiology. - : Springer Science and Business Media LLC. - 1759-5010 .- 1759-5002. ; 16:7, s. 389-406 Journal article (peer-reviewed)
3.	Pedrelli, M, et al. (author) ATHERO-PROTECTIVE PROPERTIES OF PLASMA LIPOPROTEINS FROM BROWN BEARS (URSUS ARCTOS) DURING HIBERNATION AND ACTIVE STATE 2020 In: ATHEROSCLEROSIS. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 315, s. E69-E70 Conference paper (other academic/artistic)
4.	Pedrelli, M, et al. (author) WORKSHOP 2.1: LIPOPROTEINS AND EXTRACELLULAR MATRIX. INCREASED LIPOPROTEIN BINDING TO ARTERIAL PROTEOGLYCANS AND NORMAL MACROPHAGE CHOLESTEROL EFFLUX CAPACITY DEFINE THE PRO-ATHEROGENIC FEATURE OF CKD DYSLIPIDEMIA 2016 In: ATHEROSCLEROSIS. - : Elsevier BV. - 0021-9150. ; 252, s. E237-E237 Conference paper (other academic/artistic)

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Type of publication: conference paper (2); journal article (2)

Type of content: other academic/artistic (2); peer-reviewed (2)

Author/Editor: Oorni, K (4); Camejo, G (2); Parini, P (2); Pedrelli, M (2); Hurt-Camejo, E (2); Aittokallio, T (1); show more...; Sinisalo, J. (1); Stenvinkel, P (1); Bjorkhem, I (1); Lindholm, B (1); Qureshi, AR (1); Gistera, A. (1); Minniti, ME (1); Barany, P (1); Back, M (1); Laaksonen, R. (1); Arnemo, Jon (1); Frobert, O. (1); Dikkers, A (1); Jula, A. (1); Perola, M. (1); Kindberg, Jonas (1); Walentinsson, A (1); Jauhiainen, M. (1); Yurdagul, A (1); Tabas, I (1); Kovanen, PT (1); Boren, J (1); Baumann, M (1); Nieminen, M. S. (1); Laajala, T. D. (1); Calabresi, L (1); Hilvo, M (1); Gomaraschi, M. (1); Uusitupa, M (1); Williams, K. J. (1); Ebtehaj, S. (1); Kovanen, P. T. (1); Schwab, U. (1); Kakela, R (1); Savolainen, M. J. (1); Vihervaara, T (1); Ketelhuth, D. F. J. (1); Westerstahl, M (1); Huusko, J (1); Lahteenmaki, H (1); Lokki, M. L. (1); Emma, K (1); Nguyen, S. D. (1); Aasa, U (1); show less...

University: Karolinska Institutet (4); University of Gothenburg (1); Swedish University of Agricultural Sciences (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1); Agricultural Sciences (1)

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