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- Wortman, J. R., et al.
(författare)
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The 2008 update of the Aspergillus nidulans genome annotation: A community effort
- 2009
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Ingår i: Fungal Genetics and Biology. - : Elsevier BV. - 1096-0937 .- 1087-1845. ; 46, s. S2-S13
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Tidskriftsartikel (refereegranskat)abstract
- The identification and annotation of protein-coding genes is one of the primary goals of whole-genome sequencing projects, and the accuracy of predicting the primary protein products of gene expression is vital to the interpretation of the available data and the design of downstream functional applications. Nevertheless, the comprehensive annotation of eukaryotic genomes remains a considerable challenge. Many genomes submitted to public databases, including those of major model organisms, contain significant numbers of wrong and incomplete gene predictions. We present a community-based reannotation of the Aspergillus nidulans genome with the primary goal of increasing the number and quality of protein functional assignments through the careful review of experts in the field of fungal biology. (C) 2009 Elsevier Inc. All rights reserved.
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| 2. |
- Bruno, RR, et al.
(författare)
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Failure of Lactate Clearance Predicts the Outcome of Critically Ill Septic Patients
- 2020
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Ingår i: Diagnostics (Basel, Switzerland). - : MDPI AG. - 2075-4418. ; 10:12
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Early lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a lactate clearance >0% might differ from patients with an inferior clearance in terms of intensive care management and outcomes. This study analyzes a large collective with regards to baseline risk distribution and outcomes. Methods: In total, 3299 patients were included in this analysis, consisting of 1528 (46%) ≤0% and 1771 (54%) >0% patients. The primary endpoint was intensive care unit (ICU) mortality. Multilevel logistic regression analyses were used to compare both groups: A baseline model (model 1) with lactate clearance as a fixed effect and ICU as a random effect was installed. For model 2, patient characteristics (model 2) were included. For model 3, intensive care treatment (mechanical ventilation and vasopressors) was added to the model. Models 1 and 2 were used to evaluate the primary and secondary outcomes, respectively. Model 3 was only used to evaluate the primary outcomes. Adjusted odds ratios (aORs) with respective 95% confidence intervals (CI) were calculated. Results: The cohorts had no relevant differences regarding the gender, BMI, age, heart rate, body temperature, and baseline lactate. Neither the primary infection focuses nor the ethnic background differed between both groups. In both groups, the most common infection sites were of pulmonary origin, the urinary tract, and the gastrointestinal tract. Patients with lactate clearance >0% evidenced lower sepsis-related organ failure assessment (SOFA) scores (7 ± 6 versus 9 ± 6; p < 0.001) and creatinine (1.53 ± 1.49 versus 1.80 ± 1.67; p < 0.001). The ICU mortality differed significantly (14% versus 32%), and remained this way after multivariable adjustment for patient characteristics and intensive care treatment (aOR 0.43 95% CI 0.36–0.53; p < 0.001). In the additional sensitivity analysis, the lack of lactate clearance was associated with a worse prognosis in each subgroup. Conclusion: In this large collective of septic patients, the 6 h lactate clearance is an independent method for outcome prediction.
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| 3. |
- Dankl, D, et al.
(författare)
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Red Cell Distribution Width Is Independently Associated with Mortality in Sepsis
- 2022
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Ingår i: Medical principles and practice : international journal of the Kuwait University, Health Science Centre. - : S. Karger AG. - 1423-0151. ; 31:2, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Mortality in sepsis remains high. Studies on small cohorts have shown that red cell distribution width (RDW) is associated with mortality. The aim of this study was to validate these findings in a large multicenter cohort. <b><i>Methods:</i></b> We conducted this retrospective analysis of the multicenter eICU Collaborative Research Database in 16,423 septic patients. We split the cohort in patients with low (≤15%; <i>n</i> = 7,129) and high (>15%; <i>n</i> = 9,294) RDW. Univariable and multivariable multilevel logistic regressions were used to fit regression models for the binary primary outcome of hospital mortality and the secondary outcome intensive care unit (ICU) mortality with hospital unit as random effect. Optimal cutoffs were calculated using the Youden index. <b><i>Results:</i></b> Patients with high RDW were more often older than 65 years (57% vs. 50%; <i>p</i> < 0.001) and had higher Acute Physiology and Chronic Health Evaluation (APACHE) IV scores (69 vs. 60 pts.; <i>p</i> < 0.001). Both hospital (adjusted odds ratios [aOR] 1.18; 95% CI: 1.16–1.20; <i>p</i> < 0.001) and ICU mortality (aOR 1.16; 95% CI: 1.14–1.18; <i>p</i> < 0.001) were associated with RDW as a continuous variable. Patients with high RDW had a higher hospital mortality (20 vs. 9%; aOR 2.63; 95% CI: 2.38–2.90; <i>p</i> < 0.001). This finding persisted after multivariable adjustment (aOR 2.14; 95% CI: 1.93–2.37; <i>p</i> < 0.001) in a multilevel logistic regression analysis. The optimal RDW cutoff for the prediction of hospital mortality was 16%. <b><i>Conclusion:</i></b> We found an association of RDW with mortality in septic patients and propose an optimal cutoff value for risk stratification. In a combined model with lactate, RDW shows equivalent diagnostic performance to Sequential Organ Failure Assessment (SOFA) score and APACHE IV score.
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| 4. |
- Osmani, Flutra, et al.
(författare)
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Swift : The missing link between peer-to-peer and information-centric networks
- 2012
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Ingår i: Proceeding P2P-Dep '12 Proceedings of the First Workshop on P2P and Dependability. - New York : ACM. - 9781450311489 ; , s. 4-
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Konferensbidrag (refereegranskat)abstract
- A common pitfall of many proposals on new information-centric architectures for the Internet is the imbalance of upfront costs and immediate benefits. If properly designed and deployed, information-centric architectures can accommodate the current Internet usage which is at odds with the historical design of the Internet infrastructure. To address this concern, we focus on prospects of incremental adoption of this paradigm by introducing a peer-to-peer based transport protocol for content dissemination named Swift that exhibits properties required in an Information-Centric Network (ICN), yet can be deployed in the existing Internet infrastructure. Our design integrates components while highly prioritizing modularity and sketches a path for piecemeal adoption which we consider a critical enabler of any progress in the field.
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