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| 2. |
- Karlson, Björn, et al.
(författare)
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Return to work after a workplace-oriented intervention for patients on sick-leave for burnout : a prospective controlled study
- 2010
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Ingår i: BMC Public Health. - 1471-2458 .- 1471-2458. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In the present study the effect of a workplace-oriented intervention for persons on long-term sick leave for clinical burnout, aimed at facilitating return to work (RTW) by job-person match through patient-supervisor communication, was evaluated. We hypothesised that the intervention group would show a more successful RTW than a control group.METHODS: In a prospective controlled study, subjects were identified by the regional social insurance office 2-6 months after the first day on sick leave. The intervention group (n = 74) was compared to a control group who had declined participation, being matched by length of sick leave (n = 74). The RTW was followed up, using sick-listing register data, until 1.5 years after the time of intervention.RESULTS: There was a linear increase of RTW in the intervention group during the 1.5-year follow-up period, and 89% of subjects had returned to work to some extent at the end of the follow-up period. The increase in RTW in the control group came to a halt after six months, and only 73% had returned to work to some extent at the end of the 1.5-year follow-up.CONCLUSIONS: We conclude that the present study demonstrated an improvement of long-term RTW after a workplace-oriented intervention for patients on long-term sick leave due to burnout.TRIAL REGISTRATION: Current Controlled Trials NCT01039168.
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| 3. |
- Karlson, Björn, et al.
(författare)
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Return to work after work after a workplace-oriented intervention for patients on sick-leave for burnout - a prospective controlled study
- 2010
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Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: In the present study the effect of a workplace-oriented intervention for persons on long-term sick leave for clinical burnout, aimed at facilitating return to work (RTW) by job-person match through patient-supervisor communication, was evaluated. We hypothesised that the intervention group would show a more successful RTW than a control group. Methods: In a prospective controlled study, subjects were identified by the regional social insurance office 2-6 months after the first day on sick leave. The intervention group (n = 74) was compared to a control group who had declined participation, being matched by length of sick leave (n = 74). The RTW was followed up, using sick-listing register data, until 1.5 years after the time of intervention. Results: There was a linear increase of RTW in the intervention group during the 1.5-year follow-up period, and 89% of subjects had returned to work to some extent at the end of the follow-up period. The increase in RTW in the control group came to a halt after six months, and only 73% had returned to work to some extent at the end of the 1.5-year follow-up. Conclusions: We conclude that the present study demonstrated an improvement of long-term RTW after a workplace-oriented intervention for patients on long-term sick leave due to burnout. Trial registration: Current Controlled Trials NCT01039168.
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| 5. |
- Järver, Peter, et al.
(författare)
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Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
- 2018
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathways used by cargo destined for TLR3/4/7 signaling endosomes. Both ssDNA and ssRNA conferred the endocytic inhibition, it was concentration dependent, and required a certain ssON length. The ssON-mediated inhibition modulated signaling downstream ofTLRs that localized within the affected endosomal pathway. We further show that injection of ssON dampens dsRNA-mediated inflammatory responses in the skin of non-human primates. These studies reveal a regulatory role for extracellular ssON in the endocytic uptake of TLR ligands and provide a mechanistic explanation of their immunomodulation. The identified ssON-mediated interference of endocytosis (SOMIE) is a regulatory process that temporarily dampens TLR3/4/7 signaling, thereby averting excessive immune responses.
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| 7. |
- Karlson, Björn, et al.
(författare)
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Arbetsplatsintervention vid utmattning-Dialog hjälper!
- 2007
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Ingår i: Bulletin från Centrum för yrkes- och miljömedicin, Universitetssjukhuset i Lund/Malmö akademiska sjukhus. - 1400-2833. ; :4, s. 2-2
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Nordander, Catarina, et al.
(författare)
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Fish processing work: the impact of two sex dependent exposure profiles on musculoskeletal health
- 1999
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Ingår i: Occupational and Environmental Medicine. - 1470-7926. ; 56:4, s. 256-264
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate the impact of work tasks, physical exposure, and psychosocial factors on the risk of musculoskeletal disorders in men and women, in a defined industrial setting. METHODS: 116 male and 206 female fish industry workers were compared with 129 men and 208 women with more varied work. Physical and psychosocial work load as well as musculoskeletal complaints were recorded by a questionnaire. A physical examination was performed and an observation method was used for work evaluation. 196 male and 322 female former fish processing workers received a postal questionnaire. RESULTS: The women workers in the fish industry had worse working conditions than the men for repetitiveness, constrained neck postures, and psychosocial work environment. They also had higher prevalences of complaints of the neck and shoulder (prevalence odds ratio (POR) 1.9; 95% confidence interval (95% CI) 1.1 to 3.2), neck and shoulder and elbow and hand complaints (POR 2.9; 95% CI 1.8 to 4.7 and POR 2.8; 95% CI 1.6 to 4.7, respectively). The women more often than the men left the industry because of neck and upper limb complaints. Also, women in other work had a higher prevalence of complaints of the neck and shoulder (POR 2.3; 95% CI 1.1 to 5.1) than the men. The men in the fish processing industry had a higher prevalence of complaints of the neck and shoulder than the men in other work (POR 3.6; 95% CI 1.6 to 8.0). This difference was not shown up by the questionnaire. CONCLUSIONS: Despite superficially similar work, there were clear sex differences in physical exposure and psychosocial work environment. Work in the fish processing industry was associated with a high risk of neck and upper limb disorders in women, which was probably mainly due to their extremely repetitive work tasks; the corresponding men had less repetitive work and less disorders. Also, a healthy worker effect on neck and upper limb disorders was found. The advantage of a physical examination compared with a questionnaire is clearly shown.
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| 9. |
- Ohlsson, Kerstina, et al.
(författare)
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Disorders of the neck and upper limbs in women in the fish processing industry
- 1994
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Ingår i: Occupational and Environmental Medicine. - 1470-7926. ; 51:12, s. 826-832
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE--The aim was to study the association between personal factors and physical and psychosocial work environment factors and disorders of the neck or upper limbs among women in the fish processing industry. METHODS--A cross sectional study was performed on 206 women in the fish processing industry and 208 control women. Several physical and psychosocial work environment factors were evaluated. Subjective complaints about the neck or upper limbs were assessed by questionnaire and by a clinical examination. RESULTS--The study showed a high prevalence (35%) of diagnoses in the neck or shoulders of the exposed women. All prevalence odds ratios (POR's) were substantially higher in young women. There was a pronounced dose-response relation between disorders of the neck or shoulders and duration of employment for women < 45 years old. When studying 322 former workers, the proportion who claimed musculoskeletal complaints as the reason for leaving was highest among the older women. Muscular tension, stress or worry, work strain, and the largest fraction of the work time spent with highly repetitive work tasks were clearly associated with disorders of the neck or shoulders. The measurements of the wrist movements also showed that the work was performed almost without any pauses and that the median flexion and extension velocity was high (41 degree/s). The results of observation showed good agreement with the measurements of wrist motion. CONCLUSION--Work in the fish processing industry is a risk factor for disorders of the neck and upper limbs. Due to the homogenity of the physical work load in the exposed group, we could not show any associations between the objective measurements and disorders. In cross sectional studies the risk may be underestimated due to a healthy worker effect.
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| 10. |
- Porcel Vilchez, Mario, et al.
(författare)
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Assessing the efficacy of a multispecies pheromone dispenser for the control of tortricids in apple orchards: a three-year evaluation
- 2016
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Ingår i: IOBC-WPRS Bulletin. - 1027-3115. ; 112, s. 37-39
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Konferensbidrag (refereegranskat)abstract
- We tested the possibility of using a single device for the pheromone disruption of a number of lepidopteran pests of apple in Sweden. Experiments were carried out in single conventional orchards of different size equipped with plant hedges and surrounded by variable landscapes. An increasing inhibition of the male flying activity by the synthetic airborne pheromone was measured over the three-year period for the majority of the tested species. The reduction in the larval activity of the corresponding species varied in accordance with the management and the surrounding of the orchard. Experiments in field cages showed a significant interference effect of the synthetic pheromone formulation on location of calling females by released males. The release of each component from the device was continuous over the entire flight period of the monitored species with a partial residual release in the following season. According to our results, we recommend the use of the tested device as a tool to reduce the field population of lepidopteran pests as well as to diminish the load of chemical insecticides in orchards. Due to the variability of the results in relation to single orchard features, field scouting needs to be considered as a necessary support to growers.
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| 11. |
- Porcel Vilchez, Mario, et al.
(författare)
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Influence of agricultural management on canopy-dwelling predatory and herbivorous arthropod communities in Swedish apple orchards
- 2016
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Ingår i: IOBC-WPRS Bulletin. - 1027-3115. ; 112, s. 79-82
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Local agricultural management, and in particular pesticide usage, is a major driver of many arthropod communities in agroecosystems. For example, it is known to cause a significant impact on pest's natural enemies abundance and diversity. The aim of our study was to establish the effect of agricultural management on the community of predatory and phytophagous canopy-dwelling arthropods in Swedish apple orchards. Arthropods were sampled from the tree canopy in organic and conventional orchards using a field insect aspirator. We compared the composition at family level of the two functional groups considered (predators and herbivores) using multivariate analysis. Significant differences were obtained for the predatory community between organic and conventional orchards. Principal component analysis showed a clear clustering of conventional farms mainly associated to lower abundances of predatory mirids, anthocorids, ladybirds, dustywings and spiders. Furthermore, there was a higher variation in the predatory arthropod community in organic compared to conventional orchards. No differences were observed for the herbivore community collected in suction samples between management schemes suggesting a different response pattern to orchard management compared to the predatory community during the 2013 growing season.
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| 14. |
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| 15. |
- Wass, Caroline, et al.
(författare)
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L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study.
- 2011
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Ingår i: BMC medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT: BACKGROUND: Accumulating evidence suggests that the brain's nitric oxide (NO) signalling system may be involved in the pathophysiology of schizophrenia and could thus constitute a novel treatment target. The study was designed to investigate the benefit of L-lysine, an amino acid that interferes with NO production, as an add-on treatment for schizophrenia. METHODS: L-lysine, 6 g/day, was administered to ten patients with schizophrenia as an adjunctive to their conventional antipsychotic medication. The study was designed as a single-blinded, cross-over study where patients were randomly assigned to initial treatment with either L-lysine or placebo and screened at baseline, after four weeks when treatment was crossed over, and after eight weeks. RESULTS: L-lysine treatment caused a significant increase in blood concentration of L-lysine and was tolerated well. A significant decrease in positive symptom severity, measured by the Positive And Negative Syndrome Scale (PANSS), was detected. A certain decrease in score was also observed during placebo treatment and the effects on PANSS could not unequivocally be assigned to the L-lysine treatment. Furthermore, performance on the Wisconsin Card Sorting Test was significantly improved compared to baseline, an effect probably biased by training. Subjective reports from three of the patients indicated decreased symptom severity and enhanced cognitive functioning. CONCLUSIONS: Four-week L-lysine treatment, 6 g/day, caused a significant increase in blood concentration of L-lysine that was well tolerated. Patients showed a significant decrease in positive symptoms as assessed by PANSS in addition to self-reported symptom improvement by three patients. The NO-signalling pathway is an interesting, potentially new treatment target for schizophrenia, however the effects of L-lysine need further evaluation to decide its' potentially beneficial effects on symptom severity in schizophrenia. Trial registration: NCT00996242.
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| 16. |
- Åbjörnsson, Gunnel, et al.
(författare)
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Long-term follow-up of psychological distress, social functioning, and coping style in treated and untreated patients with solvent-induced chronic toxic encephalopathy
- 1998
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Ingår i: Journal of Occupational and Environmental Medicine. - 1536-5948. ; 40:9, s. 801-807
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Tidskriftsartikel (refereegranskat)abstract
- Patients with organic solvent-induced toxic encephalopathy (TE) (n = 13) were followed up seven years after the application of an intervention program. They were also compared with untreated TE patients diagnosed at the same time (n = 26) and with unexposed referents (n = 39). Psychological distress, social function, and coping ability and style were measured with the Symptom Checklist-90, Interview Schedule of Social Interaction, and Sense of Coherence and Strategies to Handle Stress questionnaires. Both TE groups had unchanged function in neuropsychological tests. Members of the treated group had improved their social functioning and reduced their mental stress but were not any better than the untreated patients. Compared with referents, the TE patients continued to live with increased psychological distress and used predominantly emotionally focused strategies to cope with their problems. This can be a cause for concern in family life and can also make gainful work impossible.
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