| 1. |
- Jonsson, Lina, 1982, et al.
(författare)
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Characterisation of age and polarity at onset in bipolar disorder
- 2021
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Ingår i: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 219:6, s. 659-669
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Tidskriftsartikel (refereegranskat)abstract
- Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (beta = -0.34 years, s.e. = 0.08), major depression (beta = -0.34 years, s.e. = 0.08), schizophrenia (beta = -0.39 years, s.e. = 0.08), and educational attainment (beta = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
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| 2. |
- Soda, T., et al.
(författare)
-
International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
- 2020
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Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 270:7, s. 921-932
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Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most severe end of the depressive disorder spectrum, those with treatment-resistant depression and who are prescribed electroconvulsive therapy (ECT), could lead to a better understanding of the genetic underpinnings of depression. Despite ECT being one of the most effective forms of treatment for severe depressive disorders, it is usually placed at the end of treatment algorithms of current guidelines. This is perhaps because ECT has controlled risk and logistical demands including use of general anaesthesia and muscle relaxants and side-effects such as short-term memory impairment. Better understanding of the genetics and biology of ECT response and of cognitive side-effects could lead to more personalized treatment decisions. To enhance the understanding of the genomics of severe depression and ECT response, researchers and ECT providers from around the world and from various depression or ECT networks, but not limited to, such as the Psychiatric Genomics Consortium, the Clinical Alliance and Research in ECT, and the National Network of Depression Centers have formed the Genetics of ECT International Consortium (Gen-ECT-ic). Gen-ECT-ic will organize the largest clinical and genetic collection to date to study the genomics of severe depressive disorders and response to ECT, aiming for 30,000 patients worldwide using a GWAS approach. At this stage it will be the largest genomic study on treatment response in depression. Retrospective data abstraction and prospective data collection will be facilitated by a uniform data collection approach that is flexible and will incorporate data from many clinical practices. Gen-ECT-ic invites all ECT providers and researchers to join its efforts.
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| 3. |
- Ezzat, Kariem, et al.
(författare)
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The viral protein corona directs viral pathogenesis and amyloid aggregation
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid beta-peptide (A beta(42)), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
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| 4. |
- Folkersen, Lasse, et al.
(författare)
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Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
- 2020
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Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
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Tidskriftsartikel (refereegranskat)abstract
- Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
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| 5. |
- Pålsson, Namurata, et al.
(författare)
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Corrosion behavior of zinc and copper coated structural steels in soil environments
- 2022
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Ingår i: Materialwissenschaft und Werkstofftechnik. - : John Wiley and Sons Inc. - 0933-5137 .- 1521-4052. ; 53:1, s. 68-79
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Tidskriftsartikel (refereegranskat)abstract
- Corrosion behavior of structural carbon steels grade SS400 coated with copper and zinc exposed to soil sample extracted from the central part of Thailand is studied using weight loss analyses and electrochemical methods, including open circuit potential monitoring for 3600 seconds, electrochemical impedance spectroscopic analyses and potentiodynamic polarization measurements. Bare carbon steels are also examined as a reference. Open circuit potential and polarization resistance of all samples are measured on (1, 2, 3, 4, 7, 10, 15, 30, 45, 60, 77 and 91) days of exposure. Corrosion potential is monitored only on the first and last days. After 91 days, corrosion rate in millimeter per year is calculated from weight loss and corrosion product is characterized. Effects of coating material, thickness and process on corrosion resistance of carbon steel subjected to soil environment are reported and discussed.
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| 6. |
- Sazgetdinov, K., et al.
(författare)
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A SEMI-PHYSICAL MODEL TO PREDICT PLASTICITY IN RAILWAY TURNOUT CROSSINGS
- 2022
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Ingår i: CM 2022 - 12th International Conference on Contact Mechanics and Wear of Rail/Wheel Systems, Conference Proceedings. ; , s. 749-754
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Konferensbidrag (refereegranskat)abstract
- Large dynamic contact forces in railway turnouts cause severe changes in the profile of the crossing-nose. To predict these changes, the whole system model (WSM) was developed, which uses extensive FEM simulations for the rail damage calculations that are very computationally intensive. To substitute these simulations and, thus, majorly enhance the overall performance of the WSM methodology, the semi-physical plasticity (SPP) metamodel has been developed. The SPP model is based on three foundational assumptions on the wear area, shape change area and wheel profiles envelope effects to reproduce the profile development of the crossing nose. The SPP results have shown an overall good correlation with the FEM results and, due to the semi-physical nature of the model, the computational time for such predictions was significantly improved as compared to the FEM simulations (seconds instead of weeks). The developed model will be useful for effective and time-efficient rail surface damage prediction and, as part of the WSM, contribute to the fast holistic track damage prognosis.
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| 7. |
- Scott, J., et al.
(författare)
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Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
- 2019
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Ingår i: International Journal of Bipolar Disorders. - : Springer Science and Business Media LLC. - 2194-7511. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains difficult for clinicians to reliably predict which patients will benefit without recourse to a lengthy treatment trial. Greater precision in the early identification of individuals who are likely to respond to lithium is a significant unmet clinical need. Structure The H2020-funded Response to Lithium Network (R-LiNK; ) will undertake a prospective cohort study of over 300 individuals with bipolar-I-disorder who have agreed to commence a trial of lithium treatment following a recommendation by their treating clinician. The study aims to examine the early prediction of lithium response, non-response and tolerability by combining systematic clinical syndrome subtyping with examination of multi-modal biomarkers (or biosignatures), including omics, neuroimaging, and actigraphy, etc. Individuals will be followed up for 24 months and an independent panel will assess and classify each participants' response to lithium according to predefined criteria that consider evidence of relapse, recurrence, remission, changes in illness activity or treatment failure (e.g. stopping lithium; new prescriptions of other mood stabilizers) and exposure to lithium. Novel elements of this study include the recruitment of a large, multinational, clinically representative sample specifically for the purpose of studying candidate biomarkers and biosignatures; the application of lithium-7 magnetic resonance imaging to explore the distribution of lithium in the brain; development of a digital phenotype (using actigraphy and ecological momentary assessment) to monitor daily variability in symptoms; and economic modelling of the cost-effectiveness of introducing biomarker tests for the customisation of lithium treatment into clinical practice. Also, study participants with sub-optimal medication adherence will be offered brief interventions (which can be delivered via a clinician or smartphone app) to enhance treatment engagement and to minimize confounding of lithium non-response with non-adherence. Conclusions The paper outlines the rationale, design and methodology of the first study being undertaken by the newly established R-LiNK collaboration and describes how the project may help to refine the clinical response phenotype and could translate into the personalization of lithium treatment.
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| 8. |
- Six, K., et al.
(författare)
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A whole system model framework to predict damage in turnouts
- 2023
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Ingår i: Vehicle System Dynamics. - : Informa UK Limited. - 1744-5159 .- 0042-3114. ; 61:3, s. 871-891
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a whole system model framework that enables a holistic prediction of accumulated track damage in railway turnouts. A modular approach allows for insight into the interaction of different damage mechanisms such as rail profile change due to the plastic deformation and wear as well as track settlement. The methodology focuses on the two most critical areas of the turnout in terms of damage: switch and crossing panels. It is shown that at the beginning of the service life of the turnout the running surface of the rails in these areas change significantly due to plastic deformation, which in turn increases the dynamic impact forces from passing vehicles. These impact forces cause vertical track settlement that is most pronounced in the crossing area. Track settlement introduces additional dynamics into the system leading to self-reinforcing behaviour. It is shown that the proposed methodology can predict accumulated track damage accounting for the coupling between different damage modes such as track settlement, rail profiles plastic deformation and wear. It can therefore be used for holistic assessment of turnouts e.g. in design optimisation studies.
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| 9. |
- Yoshimi, N., et al.
(författare)
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Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis
- 2016
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 21:11, s. 1504-1510
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Tidskriftsartikel (refereegranskat)abstract
- Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n = 54) and age-matched male healthy controls (n = 40). Subsequently, postmortem brain analyses, genetic analyses, metabolomics of CSF samples from rats treated with lithium or valproic acid were also performed. After multivariate logistic regression, isocitric acid (isocitrate) levels were significantly higher in the CSF from BD patients than healthy controls. Furthermore, gene expression of two subtypes (IDH3A and IDH3B) of isocitrate dehydrogenase (IDH) in the dorsolateral prefrontal cortex from BD patients was significantly lower than that of controls, although the expression of other genes including, aconitase (ACO1, ACO2), IDH1, IDH2 and IDH3G, were not altered. Moreover, protein expression of IDH3A in the cerebellum from BD patients was higher than that of controls. Genetic analyses showed that IDH genes (IDH1, IDH2, IDH3A, IDH3B) and ACO genes (ACO1, ACO2) were not associated with BD. Chronic (4 weeks) treatment with lithium or valproic acid in rats did not alter CSF levels of isocitrate, and mRNA levels of Idh3a, Idh3b, Aco1 and Aco2 genes in the rat brain. These findings suggest that abnormality in the metabolism of isocitrate by IDH3A in the mitochondria plays a key role in the pathogenesis of BD, supporting the mitochondrial dysfunction hypothesis of BD. Therefore, IDH3 in the citric acid cycle could potentially be a novel therapeutic target for BD.
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| 10. |
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Broberg, K, et al.
(författare)
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Clonal chromosome aberrations are present in vivo in synovia and osteophytes from patients with osteoarthritis
- 1997
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Ingår i: Human Genetics. - : Springer Science and Business Media LLC. - 0340-6717 .- 1432-1203. ; 101:3, s. 8-295
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Tidskriftsartikel (refereegranskat)abstract
- We have previously reported recurrent clonal chromosomal aberrations in synovia, osteophytes and articular cartilage from patients with osteoarthritis (OA). In particular, gain of chromosomes 5 and 7 was found to be strongly associated with OA. In order to exclude the possibility of in vitro artefacts, we studied three to four parallel, independent cultures from ten samples of synovia and three samples of osteophytes from ten women with primary OA. In all, 40 cultures were cytogenetically analysed, 39 of which had clonal chromosomal aberrations. The most common aberrations were +7 and +5 which were found in 38 and 12 cultures, respectively. There were striking karyotype similarities among the parallel cultures from each case. Out of a total of 83 clones, only 11 were unique for one culture, 7 from synovia and 4 from osteophytes. The genetic homogeneity among different cultures from the same patients excludes the possibility of in vitro artefacts and indicates a widespread distribution of the cytogenetically aberrant clones in vivo.
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| 16. |
- Brundin, L., et al.
(författare)
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An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
- 2016
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of suicidal patients, levels of inflammatory cytokines and the kynurenine metabolite quinolinic acid (QUIN), an N-methyl-D-aspartate receptor agonist, are increased. The enzyme amino-beta-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production of the neuroprotective metabolite picolinic acid (PIC). Therefore, decreased ACMSD activity can lead to excess QUIN. We tested the hypothesis that deficient ACMSD activity underlies suicidal behavior. We measured PIC and QUIN in CSF and plasma samples from 137 patients exhibiting suicidal behavior and 71 healthy controls. We used DSM-IV and the Montgomery-Asberg Depression Rating Scale and Suicide Assessment Scale to assess behavioral changes. Finally, we genotyped ACMSD tag single nucleotide polymorphisms (SNPs) in 77 of the patients and 150 population-based controls. Suicide attempters had reduced PIC and a decreased PIC/QUIN ratio in both CSF (P<0.001) and blood (P=0.001 and P<0.01, respectively). The reductions of PIC in CSF were sustained over 2 years after the suicide attempt based on repeated measures. The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters and associated with increased CSF QUIN. Taken together, our data suggest that increased QUIN levels may result from reduced activity of ACMSD in suicidal subjects. We conclude that measures of kynurenine metabolites can be explored as biomarkers of suicide risk, and that ACMSD is a potential therapeutic target in suicidal behavior.
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| 17. |
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| 18. |
- Hansson, Caroline, 1981, et al.
(författare)
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Risk factors for suicide in bipolar disorder: a cohort study of 12 850 patients
- 2018
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 138:5, s. 456-463
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveMethodBipolar disorder carries a high risk of suicide. Identification of risk factors is important. The aim of this study was to study risk factors for suicide in a large cohort of men and women with bipolar disorder. A prospective cohort study using clinical data from the Swedish National Quality Register for Bipolar Affective Disorder (BipolaR). The outcome variable was suicide captured in the Cause of Death Register between 2004 and 2014. Hazard ratios (HR) were calculated using Cox proportional hazards models. ResultsConclusionsOf 12 850 persons (4844 men and 8006 women) with bipolar disorder, 90 (55 men and 35 women) died by suicide during the follow-up period (between 1 and 10 years). Male sex (HR 2.56), living alone (HR 2.45), previous suicide attempts (HR 4.10), comorbid psychiatric disorder (HR 2.64), recent affective episodes (HR 2.39), criminal conviction (HR 4.43), psychiatric inpatient care (HR 2.79), and involuntary commitment (HR 3.50) were significant risk factors for suicide. Several of the statistically significant risk factors for suicide in bipolar disorder differed between men and women. Risk factors for suicide in bipolar disorder include factors associated with suicide in general, but also diagnosis-specific factors.
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| 19. |
- Inai, K., et al.
(författare)
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Selective concealment of characters for privacy protection
- 2014
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Ingår i: Proceedings - International Conference on Pattern Recognition. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 333-338
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Konferensbidrag (refereegranskat)abstract
- A method of concealing characters is proposed for degrading legibility of privacy sensitive textual information in natural scene, such as car license plate numbers and name tags. An important property of the proposed method is that it realizes selective concealing of characters, that is, the proposed method degrades legibility of character regions without degrading the quality of non-character regions. This selective concealment is realized because characters have special concealment characteristics. Specifically, character legibility can be degraded by damaging stroke structure by using exemplar-based image in painting, which does not affect non-character regions. Experimental results of qualitative and quantitative evaluations have proven that the selective concealment is practically possible. Furthermore, the quantitative evaluation through a subjective experiment revealed appropriate setups of image in painting for maximizing selective concealment performance.
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| 20. |
- Mozūraitis, Raimondas, et al.
(författare)
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Male swarming aggregation pheromones increase female attraction and mating success among multiple African malaria vector mosquito species
- 2020
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Ingår i: Nature Ecology & Evolution. - : Nature Research. - 2397-334X. ; 4:10, s. 1395-1401
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Tidskriftsartikel (refereegranskat)abstract
- Accumulating behavioural data indicate that aggregation pheromones may mediate the formation and maintenance of mosquito swarms. However, chemical cues possibly luring mosquitoes to swarms have not been adequately investigated, and the likely molecular incitants of these complex reproductive behaviours remain unknown. Here we show that males of the important malaria vector species Anopheles arabiensis and An. gambiae produce and release aggregation pheromones that attract individuals to the swarm and enhance mating success. We found that males of both species released significantly higher amounts of 3-hydroxy-2-butanone (acetoin), 6-methyl-5-hepten-2-one (sulcatone), octanal, nonanal and decanal during swarming in the laboratory. Feeding males with stable-isotope-labelled glucose revealed that the males produced these five compounds. A blend composed of synthetic analogues to these swarming odours proved highly attractive to virgin males and females of both species under laboratory conditions and substantially increased mating in five African malaria vectors (An. gambiae,An. coluzzii,An. arabiensis,An. merus and An. funestus) in semi-field experiments. Our results not only narrow a conspicuous gap in understanding a vital aspect of the chemical ecology of male mosquitoes but also demonstrate fundamental roles of rhythmic and metabolic genes in the physiology and behavioural regulation of these vectors. These identified aggregation pheromones have great potential for exploitation against these highly dangerous insects. Manipulating such pheromones could increase the efficacy of malaria-vector control programmes.
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| 21. |
- Oliveira, E., et al.
(författare)
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High Levels of Hybridization between Molecular Forms of Anopheles gambiae from Guinea Bissau
- 2008
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Ingår i: Journal of medical entomology. - 0022-2585 .- 1938-2928. ; 45:6, s. 1057-1063
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Tidskriftsartikel (refereegranskat)abstract
- In the malaria vector Anopheles gambiae Giles sensu stricto, two molecular forms denoted M and S are considered units of incipient speciation within this species. Very low hybrid frequencies and significant genetic differentiation have been found in sympatric M- and S-form populations, We studied the molecular form composition and the degree of genetic differentiation at 15 microsatellites in two samples of An. gambiae collected ill two consecutive years from Bissau, Guinea Bissau. High frequencies of M/S hybrids (19-24%) were found in this area. Coincidently, very low levels of genetic differentiation were detected between forms when analysis involved microsatellites mapped at chromosome-3 (mean F-st 0.000-0.002). The single exception was the X-linked AGXH678, for which high differentiation was measured (F-st 0.158-0.301). This locus maps near the centromere of chromosome X, a low recombination region in which selection is likely to promote divergence between M and S forms. These results strongly suggest that the degree of isolation between M and S forms, considered the units of incipient speciation within An. gambiae, is not homogenous throughout the species distribution range.
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| 22. |
- Pålsson, Carina, et al.
(författare)
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Net heterotrophy in Faroe Islands clear-water lakes: causes and consequences for bacterioplankton and phytoplankton
- 2005
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Ingår i: Freshwater Biology. - : Wiley. - 0046-5070 .- 1365-2427. ; 50:12, s. 2011-2020
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Tidskriftsartikel (refereegranskat)abstract
- 1. Five oligotrophic clear-water lakes on the Faroe Islands were studied during August 2000. Algal and bacterial production rates, community respiration, and CO2 saturation were determined. In addition, we examined the plankton community composition (phytoplankton and heterotrophic nanoflagellates) and measured the grazing pressure exerted by common mixotrophic species on bacteria. 2. High respiration to primary production (6.6–33.2) and supersaturation of CO2 (830–2140 μatm) implied that the lakes were net heterotrophic and that the pelagic heterotrophic plankton were subsidised by allochthonous organic carbon. However, in spite of the apparent high level of net heterotrophy, primary production exceeded bacterial production and the food base for higher trophic levels appeared to be mainly autotrophic. 3. We suggest that the observed net heterotrophy in these lakes was a result of the oligotrophic conditions and hence low primary production in combination with an input of allochthonous C with a relatively high availability. 4. Mixotrophic phytoplankton (Cryptomonas spp., Dinobryon spp. and flagellates cf. Ochromonas spp.) constituted a large percentage of the plankton community (17–83%), possibly as a result of their capacity to exploit bacteria as a means of acquiring nutrients in these nutrient poor systems.
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| 23. |
- Pålsson, Erik, 1975, et al.
(författare)
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Cohort profile: the Swedish National Quality Register for bipolar disorder(BipolaR)
- 2022
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Ingår i: Bmj Open. - : BMJ. - 2044-6055. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- PurposeThe Swedish National Quality Register for bipolar affective disorder, BipolaR, was established in 2004 to provide nationwide indicators for quality assessment and development in the clinical care of individuals with bipolar spectrum disorder. An ancillary aim was to provide data for bipolar disorder research.ParticipantsInclusion criteria for registration in BipolaR is a diagnosis of bipolar spectrum disorder (ICD codes: F25.0, F30.1-F30.2, F30.8-F31.9, F34.0) and treatment at an outpatient clinic in Sweden. BipolaR collects data from baseline and annual follow-up visits throughout Sweden. Data is collected using questionnaires administered by healthcare staff. The questions cover sociodemographic, diagnostic, treatment, outcomes and patient reported outcome variables. The register currently includes 39 583 individual patients with a total of 75 423 baseline and follow-up records.Findings to dateData from BipolaR has been used in several peer-reviewed publications. Studies have provided knowledge on effectiveness, side effects and use of pharmacological and psychological treatment in bipolar disorder. In addition, findings on the diagnosis of bipolar disorder, risk factors for attempted and completed suicide and health economics have been reported. The Swedish Bipolar Collection project has contributed to a large number of published studies and provides important information on the genetic architecture of bipolar disorder, the impact of genetic variation on disease characteristics and treatment outcome.Future plansData collection is ongoing with no fixed end date. Currently, approximately 5000 new registrations are added each year. Cohort data are available via a formalised request procedure from Centre of Registers Vastra Gotaland (e-mail: registercentrum@vgregion.se). Data requests for research purposes require an entity responsible for the research and an ethical approval.
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| 24. |
- Pålsson, Erik, 1975, et al.
(författare)
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Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls
- 2015
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Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X. ; 25:1, s. 133-140
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Tidskriftsartikel (refereegranskat)abstract
- Glutamate is the major excitatory neurotransmitter in the brain. Aberrations in glutamate signaling have been linked to the pathophysiology of mood disorders. Increased plasma levels of glutamate as well as higher glutamine+glutamate levels in the brain have been demonstrated in patients with bipolar disorder as compared to healthy controls. In this study, we explored the glutamate hypothesis of bipolar disorder by examining peripheral and central levels of amino acids related to glutamate signaling. A total of 215 patients with bipolar disorder and 112 healthy controls from the Swedish St. Goran bipolar project were included in this study. Glutamate, glutamine, glycine, L-serine and D-serine levels were determined in serum and in cerebrospinal fluid using high performance liquid chromatography with fluorescence detection. Serum levels of glutamine, glycine and D-serine were significantly higher whereas L-serine levels were lower in patients with bipolar disorder as compared to controls. No differences between the patient and control group in amino acid levels were observed in cerebrospinal fluid. The observed differences in serum amino acid levels may be interpreted as a systemic aberration in amino acid metabolism that affects several amino acids related to glutamate signaling. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
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| 25. |
- Pålsson, Petra, et al.
(författare)
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A survey of contemporary antenatal parental education in Sweden : What is offered to expectant parents and midwives’ experiences
- 2019
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Ingår i: Sexual and Reproductive Healthcare. - : Elsevier BV. - 1877-5756. ; 20, s. 13-19
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To explore how antenatal parental education is provided in southern Sweden and midwives’ experiences of it. Methods: A cross-sectional survey with data collection from 66 antenatal clinics and 189 midwives during 2016. Descriptive and comparative statistics, chi-square and t-tests, were used to present the findings. Results: Antenatal parental education was most commonly offered in small parental groups and the number of hours provided varied between two and ten (mean 5.8) hours. A common and structured program for the sessions was used at 37.3% of the clinics. Normal birth, pain relief, partner role during birth, breastfeeding advantages and breastfeeding initiation were the topics most extensively covered. Topic coverage was in 12 topics, mostly related to the time after birth, lower than midwives’ rated importance of the topic: p-values between 0.05 and <0.01. Only 14.2% of the midwives often provided guidance to websites. Although midwives enjoyed working with antenatal parental education, they expressed lack of organizational support and lack of personal skills in group leadership and teaching. Years of experience did not significantly affect their self-rated skills in group leadership or teaching. Conclusion: These results contribute to knowledge about contemporary antenatal parental education in Sweden. Our results showed that antenatal parental education is not always in accordance with parents’ expectations, especially concerning early parenthood and guidance on the internet. To provide antenatal parental education tailored to the needs of expectant parents it is vital to develop evidence-based guidelines and to address midwives’ needs for improved skills in group leadership and teaching.
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| 26. |
- Pålsson, Petra, et al.
(författare)
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First-time fathers experiences of their prenatal preparation in relation to challenges met in the early parenthood period : Implications for early parenthood preparation
- 2017
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Ingår i: Midwifery. - : Elsevier BV. - 0266-6138. ; 50, s. 86-92
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Tidskriftsartikel (refereegranskat)abstract
- Objective to describe first-time fathers experiences of their prenatal preparation in relation to challenges met in the early parenthood period. Design a qualitative study was conducted and data was analysed with a phenomenographical approach. Setting and participants 15 first-time fathers were recruited from three postnatal units in southern Sweden and interviewed approximately one month after their baby was born. Measurements and findings three categories and 14 conceptions about fathers' experiences of their preparation emerged from the data. ‘Acquiring knowledge and forming realistic expectations' was essential for ‘Developing strategies' and ‘Being facilitated and supported' enhanced these processes. Key conclusions and implications for practice supporting fathers to develop strategies for life with a new baby and providing expert guidance to fruitful and accurate information may help the construction of a fatherhood identity and strengthen the fatherhood role. The findings can be used to develop a parental preparation for early parenthood that will correspond to fathers' needs.
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| 27. |
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| 28. |
- Salehi, Alireza M., et al.
(författare)
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Serum profiling of anorexia nervosa : A 1H NMR-based metabolomics study
- 2021
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Ingår i: European Neuropsychopharmacology. - : Elsevier. - 0924-977X .- 1873-7862. ; 49, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Our understanding of pathophysiological mechanisms underlying anorexia nervosa (AN) is incomplete. The aim was to conduct a metabolomics profiling of serum samples from women with AN (n = 65), women who have recovered from AN (AN-REC, n = 65), and age-matched healthy female controls (HC, n = 65). Serum concentrations of 21 metabolites were measured using proton nuclear magnetic resonance (1H NMR). We used orthogonal partial least-squares discriminant analysis (OPLS-DA) modeling to assign group classification based on the metabolites. Analysis of variance (ANOVA) was used to test for metabolite concentration differences across groups. The OPLS-DA model could distinguish between the AN and HC groups (p = 9.05 × 10–11 R2Y = 0.36, Q2 = 0.37) and between the AN-REC and HC groups (p = 8.47 × 10–6, R2Y = 0.36, Q2 = 0.24,), but not between the AN and AN-REC groups (p = 0.63). Lower methanol concentration in the AN and AN-REC group explained most of the variance. Likewise, the strongest finding in the univariate analyses was lower serum methanol concentration in both AN and AN-REC compared with HC, which withstood adjustment for body mass index (BMI). We report for the first time lower serum concentrations of methanol in AN. The fact that low methanol was also found in recovered AN suggests that low serum concentration of methanol could either be trait marker or a scar effect of AN.
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| 29. |
- Seyoum, A, et al.
(författare)
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Traditional use of mosquito-repellent plants in western Kenya and their evaluation in semi-field experimental huts against Anopheles gambiae : ethnobotanical studies and application by thermal expulsion and direct burning
- 2002
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Ingår i: Transactions of the Royal Society of Tropical Medicine and Hygiene. - 0035-9203 .- 1878-3503. ; 96:3, s. 225-231
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Tidskriftsartikel (refereegranskat)abstract
- Ethnobotanical survey in 2 communities in western Kenya revealed that the most commonly known repellent plants were Ocimum americanum L. (64.1%), Lantana camara L. (17.9%), Tagetes minuta L. (11.3%) and Azadirachta indica A. Juss (8.7%) on Rusinga Island, and Hyptis suaveolens Poit. (49.2%), L. camara (30.9%) and O. basilicum L. (30.4%) in Rambira. Direct burning of plants is the most common method of application for O. americanum (68.8%), L. camara (100%) and O. basilicum (58.8%). Placing branches or whole plants inside houses is most common for H. suaveolens (33.3 and 57.8% for the respective locations), A. indica (66.7 and 100%), and T. minuta (54.8 and 56.0%). The repellency of plants suggested by the ethnobotanical survey and other empirical information was evaluated against the malaria vector Anopheles gambiae s.s. Giles in experimental huts within a screenwalled greenhouse. Thermal expulsion and direct burning were tested as alternative application methods for the selected plants O. americanum, O. kilimandscharicum Guerke, O. suave Willd., L. camara, A. indica, H. suaveolens, Lippia uckambensis Spreng and Corymbia citriodora Hook. When thermally expelled, only H. suaveolens failed to repel mosquitoes, whereas the leaves of C. citriodora (74.5%, P < 0.0001), leaves and seeds of O. suave (53.1%, P < 0.0001) and O. kilimandscharicum (52.0%, P < 0.0001) were the most effective. Leaves of C. citriodora also exhibited the highest repellency (51.3%, P < 0.0001) by direct burning, followed by leaves of L. uckambensis (33.4%, P = 0.0004) and leaves and seeds of O. suave (28.0%, P = 0.0255). The combination of O. kilimandscharicum with L. uckambensis repelled 54.8% of mosquitoes (P < 0.0001) by thermal expulsion. No combination of plants increased repellency by either method. The semi-field system described appears a promising alternative to full-field trials for screening large numbers of candidate repellents without risk of malaria exposure.
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| 30. |
- Yuan, Xuemin, et al.
(författare)
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Flotation of a complex sulphide ore I. Cu/Zn selectivity control by adjusting pulp potential with different gases
- 1996
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Ingår i: International Journal of Mineral Processing. - : Elsevier BV. - 0301-7516 .- 1879-3525. ; 46:3-4, s. 155-179
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the possibility of using gases with varying oxygen activity and their influence on copper-zinc selectivity, flotation tests were done in a mechanical laboratory cell on a fine-grained complex sulphide ore with high pyrite and pyrrhotite content. The pulp environment was modified by changing the grinding media and by using different gases in the pre-conditioning a flotation steps. A statistical design with two levels of grinding media, four levels of pre-conditioning, and three levels of flotation gas type, was used. It is found that the grinding environment is the most dominant variable influencing the flotation results. Strong interactions exist between the pre-conditioning type and the flotation gas for mild steel grinding. Such interactions, and even the direct influence of pre-conditioning and flotation gas type, are statistically insignificant for stainless steel grinding, which often gave good copper flotation. The Cu/Zn selectivity shows a strong dependence on the pre-conditioning type and flotation gases for mild steel grinding, but not for stainless steel grinding. The best Cu/Zn selectivity happens for the combination of 5% oxygen pre-conditioning and air flotation after mild steel grinding. It seems that galvanic reactions after or during the mild steel grinding facilitate surface oxidation of sulphides. A mechanism similar to ferric leaching is proposed. As expected, it was observed that the oxidising or reducing environment in the pulp, as measured by the pulp potential, has a strong influence on the flotation results.
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| 31. |
- Yuan, Xuemin, et al.
(författare)
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Flotation of a complex sulphide ore II. Influence of grinding environments on Cu/Fe sulphide selectivity and pulp chemistry
- 1996
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Ingår i: International Journal of Mineral Processing. - 0301-7516 .- 1879-3525. ; 46:3-4, s. 181-204
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the possibility of using gases with varying oxygen activity and their influence on copper-zinc selectivity, flotation tests were done in a mechanical laboratory cell on a fine-grained complex sulphide ore with high pyrite and pyrrhotite content. The pulp environment was modified by changing the grinding media and by using different gases in the pre-conditioning a flotation steps. A statistical design with two levels of grinding media, four levels of pre-conditioning, and three levels of flotation gas type, was used. It is found that the grinding environment is the most dominant variable influencing the flotation results. Strong interactions exist between the pre-conditioning type and the flotation gas for mild steel grinding. Such interactions, and even the direct influence of pre-conditioning and flotation gas type, are statistically insignificant for stainless steel grinding, which often gave good copper flotation. The Cu/Zn selectivity shows a strong dependence on the pre-conditioning type and flotation gases for mild steel grinding, but not for stainless steel grinding. The best Cu/Zn selectivity happens for the combination of 5% oxygen pre-conditioning and air flotation after mild steel grinding. It seems that galvanic reactions after or during the mild steel grinding facilitate surface oxidation of sulphides. A mechanism similar to ferric leaching is proposed. As expected, it was observed that the oxidising or reducing environment in the pulp, as measured by the pulp potential, has a strong influence on the flotation results.
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| 32. |
- Yuan, Xuemin, et al.
(författare)
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Statistical interpretation of flotation kinetics for a complex sulphide ore
- 1996
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Ingår i: Minerals Engineering. - : Elsevier BV. - 0892-6875 .- 1872-9444. ; 9:4, s. 429-442
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Tidskriftsartikel (refereegranskat)abstract
- Kinetic flotation models were applied to data from tests with reactive gases (hydrogen and sulphur dioxide) on a complex sulphide ore. The models were evaluated by statistical techniques, after non-linear regression on the model parameters. It is found that a first order model with rectangular distribution of floatability fits the test data very well. Statistical tests on copper, silver and lead kinetic data show that reactive gases have a greater influence on silver mineral flotation compared to copper-lead minerals. Sulphur dioxide generally gives higher ultimate silver recoveries than sodium bisulphite, and the magnitudes depend on the interactions between the modifiers and theflotation gases (5% H2 N2 and air). Correlation analysis suggests that silver flotation is probably determined by the floatability of a separate mineral such as tetrahedrite. Multivariate analysis on pulp chemistry data reveals that the pulp pH is the most significant variable among the pulp chemistry data, provided the grinding is iron free. The pH effect is attributed to the addition of sulphur dioxide. After autogenous or non-reducing grinding, the naturally-occurring variations in redox levels are too small to influence the flotation results, despite the tests being made with a complex sulphide ore.
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| 33. |
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