| 1. |
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| 2. |
- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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| 3. |
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| 4. |
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| 5. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 7. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 9. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 10. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 11. |
- Abolfathi, Bela, et al.
(författare)
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The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
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Tidskriftsartikel (refereegranskat)abstract
- The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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| 12. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 13. |
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| 14. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 15. |
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| 16. |
- Blanton, Michael R., et al.
(författare)
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Sloan Digital Sky Survey IV : Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
- 2017
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Ingår i: Astronomical Journal. - : IOP Publishing Ltd. - 0004-6256 .- 1538-3881. ; 154:1
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Tidskriftsartikel (refereegranskat)abstract
- We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.
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| 17. |
- Gimeno-Miguel, Antonio, et al.
(författare)
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Multimorbidity patterns in patients with heart failure : an observational Spanish study based on electronic health records
- 2019
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 9:12
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To characterise the comorbidities of heart failure (HF) in men and women, to explore their clustering into multimorbidity patterns, and to measure the impact of such patterns on the risk of hospitalisation and mortality.Design Observational retrospective population study based on electronic health records.Setting EpiChron Cohort (Aragon, Spain).Participants All the primary and hospital care patients of the EpiChron Cohort with a diagnosis of HF on 1 January 2011 (ie, 8488 women and 6182 men). We analysed all the chronic diseases registered in patients electronic health records until 31 December 2011.Primary outcome We performed an exploratory factor analysis to identify the multimorbidity patterns in men and women, and logistic and Cox proportional-hazards regressions to investigate the association between the patterns and the risk of hospitalisation in 2012, and of 3-year mortality.Results Almost all HF patients (98%) had multimorbidity, with an average of 7.8 chronic diseases per patient. We identified six different multimorbidity patterns, named cardiovascular, neurovascular, coronary, metabolic, degenerative and respiratory. The most prevalent were the degenerative (64.0%) and cardiovascular (29.9%) patterns in women, and the metabolic (49.3%) and cardiovascular (43.2%) patterns in men. Every pattern was associated with higher hospitalisation risks; and the cardiovascular, neurovascular and respiratory patterns significantly increased the likelihood of 3-year mortality.Conclusions Multimorbidity is the norm rather than the exception in patients with heart failure, whose comorbidities tend to cluster together beyond simple chance in the form of multimorbidity patterns that have different impact on health outcomes. This knowledge could be useful to better understand common pathophysiological pathways underlying this condition and its comorbidities, and the factors influencing the prognosis of men and women with HF. Further large scale longitudinal studies are encouraged to confirm the existence of these patterns as well as their differential impact on health outcomes.
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| 18. |
- Torres-Espinola, Francisco J, et al.
(författare)
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Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age : A Follow Up from the PREOBE Cohort
- 2015
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Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Brain development in fetal life and early infancy is critical to determine lifelong performance in various neuropsychological domains. Metabolic pathologies such as overweight, obesity, and gestational diabetes in pregnant women are prevalent and increasing risk factors that may adversely affect long-term brain development in their offspring. Objective: The objective of this research was to investigate the influence of maternal metabolic pathologies on the neurodevelopment of the offspring at 6 and 18 months of life. Design This was a prospective case-control study of 331 mother- and child pairs from Granada, Spain. The mothers were included during pregnancy into four groups according to their pre-gestational body mass index and their gestational diabetes status; overweight (n:56), obese (n:64), gestational diabetic (n:79), and healthy normal weight controls (n:132). At 6 months and 18 months we assessed the children with the Bayley III scales of neurodevelopment. Results: At 6 months (n=215), we found significant group differences in cognition composite language, and expressive language. Post hoc test revealed unexpectedly higher scores in the obese group compared to the normal weight group and a similar trend in overweight and diabetic group. The effects on language remained significant after adjusting for confounders with an adjusted odds ratio for a value above median in composite language score of 3.3 (95% CI: 1.1, 10.0; p=0.035) for children of obese mothers. At 18 month (n=197), the off-spring born to obese mothers had lost five points in language composite scores and the previous differences in language and cognition was replaced by a suggestive trend of lower gross motor scores in the overweight, obese, and diabetic groups. Conclusions: Infants of obese mothers had a temporary accelerated development of cognition and language, followed by a rapid deceleration until 18 months of age, particularly of language scores. This novel observation prompts further confirmative studies to explore possible placental and neurodevelopmental mechanisms involved.
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| 19. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 20. |
- Alberdi, Antxon, et al.
(författare)
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The jet of the Low Luminosity AGN of M81. Evidence of Precession
- 2013
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 61
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Konferensbidrag (refereegranskat)abstract
- In this contribution, we summarize our main results of a big campaign of global VLBI observations of the AGN in M81 (M81*) phase-referenced to the radio supernova SN 1993J. Thanks to the precise multi-epoch and multi-frequency astrometry, we have determined the normalized core-shift of the relativistic jet of M81* and estimated both the magnetic field and the particle density at the jet base. We have also found evidence of jet precession in M81* coming from the systematic time evolution of the jet orientation correlated with changes in the overall flux density.
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| 21. |
- Beswick, R. J., et al.
(författare)
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SKA studies of nearby galaxies: Star-formation, accretion processes and molecular gas across all environments
- 2014
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Ingår i: Proceedings of Science. - 1824-8039. ; 9-13-June-2014
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Konferensbidrag (refereegranskat)abstract
- The SKA will be a transformational instrument in the study of our local Universe. In particular, by virtue of its high sensitivity (both to point sources and diffuse low surface brightness emission), angular resolution and the frequency ranges covered, the SKA will undertake a very wide range of astrophysical research in the field of nearby galaxies. By surveying vast numbers of nearby galaxies of all types with mJy sensitivity and sub-arcsecond angular resolutions at radio wavelengths, the SKA will provide the cornerstone of our understanding of star-formation and accretion activity in the local Universe. In this chapter we outline the key continuum and molecular line science areas where the SKA, both during phase-1 and when it becomes the full SKA, will have a significant scientific impact.
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| 22. |
- Costagliola, Francesco, 1981, et al.
(författare)
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Molecules as tracers of galaxy evolution: an EMIR survey I. Presentation of the data and first results
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 528
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We investigate the molecular gas properties of a sample of 23 galaxies in order to find and test chemical signatures of galaxy evolution and to compare them to IR evolutionary tracers. Methods. Observation at 3 mm wavelengths were obtained with the EMIR broadband receiver, mounted on the IRAM 30 m telescope on Pico Veleta, Spain. We compare the emission of the main molecular species with existing models of chemical evolution by means of line intensity ratios diagrams and principal component analysis. Results. We detect molecular emission in 19 galaxies in two 8 GHz-wide bands centred at 88 and 112 GHz. The main detected molecules are CO, (CO)-C-13, HCN, HNC, HCO+, CN, and C2H. We also detect HC3N J = 10-9 in the galaxies IRAS 17208, IC 860, NGC 4418, NGC 7771, and NGC 1068. The only HC3N detections are in objects with HCO+/HCN 0.8). The brightest HC3N emission is found in IC 860, where we also detect the molecule in its vibrationally excited state. We find low HNC/HCN line ratios (
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| 23. |
- Horesh, Assaf, et al.
(författare)
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A Non-equipartition Shock Wave Traveling in a Dense Circumstellar Environment around SN 2020oi
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 903:2
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Tidskriftsartikel (refereegranskat)abstract
- We report the discovery and panchromatic follow-up observations of the young Type Ic supernova (SN Ic) SN 2020oi in M100, a grand-design spiral galaxy at a mere distance of 14 Mpc. We followed up with observations at radio, X-ray, and optical wavelengths from only a few days to several months after explosion. The optical behavior of the supernova is similar to those of other normal SNe Ic. The event was not detected in the X-ray band but our radio observations revealed a bright mJy source (L-nu approximate to 1.2 x 10(27) erg s(-1) Hz(-1)). Given the relatively small number of stripped envelope SNe for which radio emission is detectable, we used this opportunity to perform a detailed analysis of the comprehensive radio data set we obtained. The radio-emitting electrons initially experience a phase of inverse Compton cooling, which leads to steepening of the spectral index of the radio emission. Our analysis of the cooling frequency points to a large deviation from equipartition at the level of epsilon(e)/epsilon(B) greater than or similar to 200, similar to a few other cases of stripped envelope SNe. Our modeling of the radio data suggests that the shock wave driven by the SN ejecta into the circumstellar matter (CSM) is moving at similar to 3 x 10(4) km s(-1). Assuming a constant mass loss from the stellar progenitor, we find that the mass-loss rate is (M)over dot approximate to 1.4 x 10(-4) M-circle dot yr(-1) for an assumed wind velocity of 1000 km s(-1). The temporal evolution of the radio emission suggests a radial CSM density structure steeper than the standard r(-2).
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| 24. |
- Kool, Erik C., et al.
(författare)
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A radio-detected type Ia supernova with helium-rich circumstellar material
- 2023
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 617:7961, s. 477-482
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Tidskriftsartikel (refereegranskat)abstract
- Type Ia supernovae (SNe Ia) are thermonuclear explosions of degenerate white dwarf stars destabilized by mass accretion from a companion star1, but the nature of their progenitors remains poorly understood. A way to discriminate between progenitor systems is through radio observations; a non-degenerate companion star is expected to lose material through winds2 or binary interaction3 before explosion, and the supernova ejecta crashing into this nearby circumstellar material should result in radio synchrotron emission. However, despite extensive efforts, no type Ia supernova (SN Ia) has ever been detected at radio wavelengths, which suggests a clean environment and a companion star that is itself a degenerate white dwarf star4,5. Here we report on the study of SN 2020eyj, a SN Ia showing helium-rich circumstellar material, as demonstrated by its spectral features, infrared emission and, for the first time in a SN Ia to our knowledge, a radio counterpart. On the basis of our modelling, we conclude that the circumstellar material probably originates from a single-degenerate binary system in which a white dwarf accretes material from a helium donor star, an often proposed formation channel for SNe Ia (refs. 6,7). We describe how comprehensive radio follow-up of SN 2020eyj-like SNe Ia can improve the constraints on their progenitor systems.
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| 25. |
- Lundqvist, Peter, et al.
(författare)
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The Deepest Radio Observations of Nearby SNe Ia : Constraining Progenitor Types and Optimizing Future Surveys
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 890:2
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Tidskriftsartikel (refereegranskat)abstract
- We report deep radio observations of nearby Type Ia supernovae (SNe Ia) with the electronic Multi-Element Radio Linked Interferometer Network and the Australia Telescope Compact Array. No detections were made. With standard assumptions for the energy densities of relativistic electrons going into a power-law energy distribution and the magnetic field strength (epsilon(e) = epsilon(B)=.0.1), we arrive at upper limits on mass-loss rate for the progenitor system of SN.2013dy.(SN 2016coj, SN 2018gv, SN 2018pv, SN 2019np) of M less than or similar to 12 (2.8, 1.3, 2.1, 1.7) x 10(-8) M-circle dot yr(-1) (v(w)/100 km s-(1)), where v(w) is the wind speed of the mass loss. To SN.2016coj, SN 2018gv, SN 2018pv, and SN 2019np we add radio data for 17 other nearby SNe.Ia and model their nondetections. With the same model as described, all 21 SNe Ia have M less than or similar to 4 x 10(-8) M-circle dot yr(-1) (v(w)/ 100 km s(-1)). We compare those limits with the expected mass-loss rates in different single-degenerate progenitor scenarios. We also discuss how information on oe and oB can be obtained from late observations of SNe.Ia and the youngest SN.Ia remnant detected in radio, G1.9+0.3, as well as strippedenvelope core-collapse SNe. We highlight SN.2011dh and argue for epsilon e approximate to 0.1 and epsilon(B) approximate to 0.0033. Finally, we discuss strategies to observe at radio frequencies to maximize the chance of detection, given the time since explosion, the distance to the SN, and the telescope sensitivity.
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| 26. |
- Marti-Vidal, Ivan, 1980, et al.
(författare)
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Over-resolution of compact sources in interferometric observations
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 541, s. A135-
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Forskningsöversikt (refereegranskat)abstract
- We review the effects of source size in interferometric observations and focus on the cases of very compact sources.If a source is extremely compact and/or weak (so it is not possible to detect signature of source structure in the visibilities) we describe a test of hypothesis that can be used to set a strong upper limit to the size of the source. We also estimate the minimum possible size of a source whose structure can still be detected by an interferometer (i.e., the maximum theoretical over-resolution power of an interferometer), which depends on the overall observing time, the compactness in the array distribution, and the sensitivity of the receivers. As a result, and depending on the observing frequency, the over-resolution power of forthcoming ultra-sensitive arrays, like the Square Kilometer Array (SKA), may allow us to study details of sources at angular scales down to a few micro-arcsec.
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| 27. |
- Medina-Dols, Aina, et al.
(författare)
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Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
- 2024
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Ingår i: Cell Death Discovery. - : Springer Nature. - 2058-7716. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial cells (ECs) in the context of stroke outcome. PATJ expression analyses in patient's blood revealed that: (i) the risk allele of rs76221407 induces higher expression of PATJ, (ii) PATJ is downregulated 24 h after IS, and (iii) its expression is significantly lower in those patients with functional independence, measured at 3 months with the modified Rankin scale ((mRS) <= 2), compared to those patients with marked disability (mRS = 4-5). In mice brains, PATJ was also downregulated in the injured hemisphere at 48 h after ischemia. Oxygen-glucose deprivation and hypoxia-dependent of Hypoxia Inducible Factor-1 alpha also caused PATJ depletion in ECs. To study the effects of PATJ downregulation, we generated PATJ-knockdown human microvascular ECs. Their transcriptomic profile evidenced a complex cell reprogramming involving Notch, TGF-ss, PI3K/Akt, and Hippo signaling that translates in morphological and functional changes compatible with endothelial to mesenchymal transition (EndMT). PATJ depletion caused loss of cell-cell adhesion, upregulation of metalloproteases, actin cytoskeleton remodeling, cytoplasmic accumulation of the signal transducer C-terminal transmembrane Mucin 1 (MUC1-C) and downregulation of Notch and Hippo signaling. The EndMT phenotype of PATJ-depleted cells was associated with the nuclear recruitment of MUC1-C, YAP/TAZ, beta-catenin, and ZEB1. Our results suggest that PATJ downregulation 24 h after IS promotes EndMT, an initial step prior to secondary activation of a pro-angiogenic program. This effect is associated with functional independence suggesting that activation of EndMT shortly after stroke onset is beneficial for stroke recovery.
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| 28. |
- Perez-Torres, Miguel Angel, et al.
(författare)
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Constraining the progenitor of the type Ia SN 2014J with the EVN and eMERLIN
- 2014
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Ingår i: Proceedings of Science. - 1824-8039.
-
Konferensbidrag (refereegranskat)abstract
- We report the deepest radio interferometric observations of the closest Type Ia supernova in decades, SN 2014J, which exploded in the nearby galaxy M 82. These observations represent, together with radio observations of SNe 2011fe, the most sensitive radio studies of a Type Ia SN ever. We constrain the mass-loss rate from the progenitor system of SN 2014J to M ≲ 7.0 × 10-10 M⊙yr-1 (for a wind speed of 100 km s-1). Most single-degenerate scenarios, i.e., the wide family of progenitor systems where a red giant, main-sequence, or sub-giant star donates mass to a exploding white dwarf, are ruled out by our observations. On the contrary, our stringent upper limits to the radio emission from SN 2014 favor a double-degenerate scenario-involving two WD stars-for the progenitor system of SN 2014J, as such systems have less circumstellar gas than our upper limits. Thus, the evidence from SNe 2011fe and 2014J points in the direction of a double-degenerate scenario for both. Looking into the future, we note that the huge improvement in sensitivity of the SKA with respect to its predecessors will allow us to determine which progenitor scenario (single-degenerate vs. double-degenerate) applies to a large sample of nearby Type Ia SNe, thus unambiguously solving this issue. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.
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| 29. |
- Perez-Torres, Miguel Angel, et al.
(författare)
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Constraints on the Progenitor System and the Environs of SN 2014J from Deep Radio Observations
- 2014
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 792:1, s. Art. no. 38-
-
Tidskriftsartikel (refereegranskat)abstract
- We report deep EVN and eMERLIN observations of the Type Ia SN 2014J in the nearby galaxy M82. Our observations represent, together with JVLA observations of SNe 2011fe and 2014J, the most sensitive radio studies of Type Ia SNe ever. By combining data and a proper modeling of the radio emission, we constrain the mass-loss rate from the progenitor system of SN 2014J to (M) over dot less than or similar to 7.0 x 10(-10) M yr(-1) (for a wind speed of 100 km s(-1)). If the medium around the supernova is uniform, then n(ISM) less than or similar to 1.3 cm(-3), which is the most stringent limit for the (uniform) density around a Type Ia SN. Our deep upper limits favor a double-degenerate (DD) scenario-involving two WD stars-for the progenitor system of SN 2014J, as such systems have less circumstellar gas than our upper limits. By contrast, most single-degenerate (SD) scenarios, i.e., the wide family of progenitor systems where a red giant, main-sequence, or sub-giant star donates mass to an exploding WD, are ruled out by our observations. (While completing our work, we noticed that a paper by Margutti et al. was submitted to The Astrophysical Journal. From a non-detection of X-ray emission from SN 2014J, the authors obtain limits of (M) over dot less than or similar to 1.2 x 10(-9) M-circle dot yr(-1) (for a wind speed of 100 km s(-1)) and n(ISM) less than or similar to 3.5 cm(-3), for the rho proportional to r(-2) wind and constant density cases, respectively. As these limits are less constraining than ours, the findings by Margutti et al. do not alter our conclusions. The X-ray results are, however, important to rule out free-free and synchrotron self-absorption as a reason for the radio non-detections.) Our estimates on the limits on the gas density surrounding SN2011fe, using the flux density limits from Chomiuk et al., agree well with their results. Although we discuss the possibilities of an SD scenario passing observational tests, as well as uncertainties in the modeling of the radio emission, the evidence from SNe 2011fe and 2014J points in the direction of a DD scenario for both.
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| 30. |
- Perez-Torres, Miguel Angel, et al.
(författare)
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Core-collapse and type ia supernovae with the SKA
- 2014
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Ingår i: Proceedings of Science. - 1824-8039. ; 9-13-June-2014
-
Konferensbidrag (refereegranskat)abstract
- Core-collapse SNe (CCSNe): Systematic searches of radio emission from CCSNe are still lacking, and only targeted searches of radio emission from just some of the optically discovered CCSNe in the local universe have been carried out. Optical searches miss a significant fraction of CCSNe due to dust obscuration; CCSN radio searches are thus more promising for yielding the complete, unobscured star-formation rates in the local universe. The SKA yields the possibility to piggyback for free in this area of research by carrying out commensal, wide-field, blind transient survey observations. SKA1-SUR should be able to discover several hundreds of CCSNe in just one year, compared to about a dozen CCSNe that the VLASS would be able to detect in one year, at most. SKA, with an expected sensitivity ten times that of SKA1, is expected to detect CCSNe in the local Universe by the thousands. Therefore, commensal SKA observations could easily result in an essentially complete census of all CCSNe in the local universe, thus yielding an accurate determination of the volumetric CCSN rate. Type Ia SNe: We advocate for the use of the SKA to search for the putative prompt (first few days after the explosion) radio emission of any nearby type Ia SN, via target-of-opportunity observations. The huge improvement in sensitivity of the SKA with respect to its predecessors will allow to unambiguously discern which progenitor scenario (single-degenerate vs. double-degenerate) applies to them.
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| 31. |
- Perez-Torres, Miguel Angel, et al.
(författare)
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What is the progenitor of the Type Ia SN 2014J?
- 2014
-
Ingår i: Proceedings of the 11th Scientific Meeting of the Spanish Astronomical Society - Highlights of Spanish Astrophysics VIII, SEA 2014. ; , s. 540-546
-
Konferensbidrag (refereegranskat)abstract
- We report the deepest radio interferometric observations of the closest Type Ia supernova in decades, SN 2014J, which exploded in the nearby galaxy M 82. These observations represent, together with radio observations of SNe 2011fe, the most sensitive radio studies of a Type Ia SN ever. We constrain the mass-loss rate from the progenitor system of SN 2014J lower than 7.0 × 10^(−10) M yr^(−1) (for a wind speed of 100 km s^(−1) ). Our deep upper limits favor a double-degenerate scenario–involving two WD stars–for the progenitor system of SN 2014J, as such systems have less circumstellar gas than our upper limits. By contrast, most single-degenerate scenarios, i.e., the wide family of progenitor systems where a red giant, main-sequence, or sub-giant star donates mass to a exploding white dwarf, are ruled out by our observations. The evidence from SNe 2011fe and 2014J points in the direction of a double-degenerate scenario for both.
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| 32. |
- Privon, G., et al.
(författare)
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EXCITATION MECHANISMS FOR HCN(1-0) AND HCO+ (1-0) IN GALAXIES FROM THE GREAT OBSERVATORIES ALL-SKY LIRG SURVEY
- 2015
-
Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 814:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present new Institut de Radioastronomie Millimetrique (TRAM) 30 m spectroscopic observations of the similar to 88 GHz band, including emission from the CCH (N = 1 -> 0) multiplet, HCN (J = 1 -> 0), HCO (J = 1 -> 0), and HNC (J = 1 -> 0), for a sample of 58 local luminous and ultraluminous infrared galaxies from the Great Observatories All-sky LIRG Survey (GOALS). By combining our new TRAM data with literature data and Spitzer /IRS spectroscopy, we study the correspondence between these putative tracers of dense gas and the relative contribution of active galactic nuclei (AGNs) and star formation to the mid-infrared luminosity of each system. We find the HCN (1-0) emission to be enhanced in AGN-dominated systems (L'(HCN(1 0))/ L'(HCO+(1-o))) = 1.84), compared to composite and starburst-dominated systems (L'HCN(1413/(1-0)) = 1.14, and 0.88, respectively). However, some composite and starburst systems have LH/ CN (1 0) /LH/ CO (1 0) ratios comparable to those of AGNs, indicating that enhanced HCN emission is not uniquely associated with energetically dominant AGNs. After removing AGN-dominated systems from the sample, we find a linear relationship (within the uncertainties) between logio(L'(HCN(1-0))) and log(10)(LIR), consistent with most previous findings. Lc N(1 0) /LIR, typically interpreted as the dense-gas depletion time, appears to have no systematic trend with LIR for our sample of luminous and ultraluminous infrared galaxies, and has significant scatter. The galaxyintegrated L'(HCN(1-0)) and L'(HCO+(1-0)) emission do not appear to have a simple interpretation in terms of the AGN dominance or the star formation rate, and are likely determined by multiple processes, including density and radiative effects.
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| 33. |
- Richards, Stephen, et al.
(författare)
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Genome Sequence of the Pea Aphid Acyrthosiphon pisum
- 2010
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 8:2, s. e1000313-
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Tidskriftsartikel (refereegranskat)abstract
- Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.
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| 34. |
- Rodriguez, M. I., et al.
(författare)
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The molecular gas content of ULIRG type 2 quasars at z
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 565
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Tidskriftsartikel (refereegranskat)abstract
- We present new results of CO(1-0) spectroscopic observations of four Sloan Digital Sky Survey (SDSS) type 2 quasars (QSO2) at z similar to 0.3, observed with the 30-m IRAM radio telescope. The QSO2 have infrared luminosities in the ultra-luminous infrared galaxies (ULIRG) regime. We confirm the CO(1-0) detection in one of our four QSO2, SDSS J1543-00, with L-CO' and M-H2 (1.2 +/- 0.2) x 10(10) K km s(-1) pc(2) and (9.4 +/- 1.4) x 10(9) M-circle dot, respectively. The full width at half maximum (FWHM) of the CO(1-0) line is =575 +/- 102 km s(-1). No CO(1-0)) emission is detected in SDSS J0903+02, SDSS j1337-01, SDSS j1520-01 above 3 sigma, yielding upper limits on M(H-2) similar to 9.6, 4.3 and 5.1 x 10(9) M-circle dot, respectively. We expand previous studies of the molecular gas content of intermediate z QSO2 into the ULIRG regime. Taking into account nine QSO2 at z similar to 0.3-1.0 from the literature, we discuss the location of the 13 ULIRG QSO2 at z
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| 35. |
- Romero-Cañizales, C., et al.
(författare)
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e-MERLIN and VLBI observations of the luminous infrared galaxy IC 883: a nuclear starburst and an AGN candidate revealed
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 543, s. Article Number: A72-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The high star formation rates of luminous infrared galaxies (LIRGs) make them ideal places for core-collapse supernova (CCSN) searches. Massive star formation can often be found in coexistence with an active galactic nucleus (AGN), contributing jointly to the energy source of LIRGs. At radio frequencies, where light is unaffected by dust extinction, it is possible to detect compact components within the innermost LIRG nuclear regions, such as SNe and SN remnants, as well as AGN buried deep in the LIRG nuclei. Aims. Our study of the LIRG IC 883 aims at: (i) investigating the parsec-scale radio structure of the (circum-) nuclear regions of IC 883; (ii) detecting at radio frequencies the two recently reported circumnuclear SNe 2010cu and 2011hi, which were discovered by near-IR (NIR) adaptive optics observations of IC 883; and (iii) further investigating the nature of SN 2011hi at NIR wavelengths. Methods. We used the electronic European very long baseline interferometry (VLBI) Network (e-EVN) at 5 GHz, and the electronic Multi-Element Remotely Linked Interferometer Network (e-MERLIN) at 6.9 GHz, to observe contemporaneously the LIRG IC 883 at high angular-resolution (from tens to hundreds of milliarcsec) and with high sensitivity (
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| 36. |
- Romero-Cañizales, C., et al.
(författare)
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The nature of supernovae 2010O and 2010P in Arp 299 - II. Radio emission
- 2014
-
Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 440:2, s. 1067-1079
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Tidskriftsartikel (refereegranskat)abstract
- We report radio observations of two stripped-envelope supernovae (SNe), 2010O and 2010P, which exploded within a few days of each other in the luminous infrared galaxy Arp 299. Whilst SN 2010O remains undetected at radio frequencies, SN 2010P was detected (with an astrometric accuracy better than 1 milli arcsec in position) in its optically thin phase in epochs ranging from similar to 1 to similar to 3 yr after its explosion date, indicating a very slow radio evolution and a strong interaction of the SN ejecta with the circumstellar medium. Our late-time radio observations towards SN 2010P probe the dense circumstellar envelope of this SN, and imply M [M-circle dot yr(-1)]/upsilon(wind) [10 km s(-1)] = (3.0 - 5.1) x 10(-5), with a 5 GHz peak luminosity of similar to 1.2 x 10(27) erg s(- 1) Hz(- 1) on day similar to 464 after explosion. This is consistent with a Type IIb classification for SN 2010P, making it the most distant and most slowly evolving Type IIb radio SN detected to date.
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| 37. |
- Romero-Cañizales, C., et al.
(författare)
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Unveiling the AGN in IC 883: discovery of a parsec-scale radio jet
- 2017
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 467:2, s. 2504-2516
-
Tidskriftsartikel (refereegranskat)abstract
- IC 883 is a luminous infrared galaxy (LIRG) classified as a starburst- active galactic nucleus (AGN) composite. In a previous study, we detected a low- luminosity AGN (LLAGN) radio candidate. Here, we report on our radio follow- up at three frequencies that provides direct and unequivocal evidence of the AGN activity in IC 883. Our analysis of archival X-ray data, together with the detection of a transient radio source with luminosity typical of bright supernovae, gives further evidence of the ongoing star formation activity, which dominates the energetics of the system. At sub- parsec scales, the radio nucleus has a core-jet morphology with the jet being a newly ejected component showing a subluminal proper motion of 0.6-1 c. The AGN contributes less than 2 per cent of the total IR luminosity of the system. The corresponding Eddington factor is similar to 10(-3), suggesting this is a low-accretion rate engine, as often found in LLAGNs. However, its high bolometric luminosity (similar to 10(44) erg s(-1)) agrees better with a normal AGN. This apparent discrepancy may just be an indication of the transition nature of the nucleus from a system dominated by star formation, to an AGN-dominated system. The nucleus has a strongly inverted spectrum and a turnover at similar to 4.4 GHz, thus qualifying as a candidate for the least luminous (L(5.0)GHz similar to 6.3 x 10(28) erg s(-1) Hz(-1)) and one of the youngest (similar to 3 x 10(3) yr) gigahertz-peaked spectrum (GPS) sources. If the GPS origin for the IC 883 nucleus is confirmed, then advanced mergers in the LIRG category are potentially key environments to unveil the evolution of GPS sources into more powerful radio galaxies.
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| 38. |
- Seyed Khoei, Nazlisadat, et al.
(författare)
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Circulating bilirubin levels and risk of colorectal cancer : serological and Mendelian randomization analyses
- 2020
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Ingår i: BMC Medicine. - : Springer Nature. - 1741-7015. ; 18:1
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex.METHODS: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.RESULTS: The associations between circulating UCB levels and CRC risk differed by sex (Pheterogeneity = 0.008). Among men, higher levels of UCB were positively associated with CRC risk (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.04-1.36; per 1-SD increment of log-UCB). In women, an inverse association was observed (OR = 0.86 (0.76-0.97)). In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02-1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96-1.06); P = 0.73). Raised bilirubin levels, predicted by instrumental variables excluding rs6431625, were suggestive of an inverse association with CRC in men, but not in women. These differences by sex did not reach formal statistical significance (Pheterogeneity ≥ 0.2).CONCLUSIONS: Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.
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| 39. |
- Torres-Espinola, Francisco J., et al.
(författare)
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Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes
- 2018
-
Ingår i: PLOS ONE. - : Public Library Science. - 1932-6203. ; 13:9
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Overweight, obesity, and gestational diabetes (GD) during pregnancy may negatively affect neurodevelopment in the offspring. However, the mechanisms are unclear and objective measures of neurodevelopment in infancy are scarce. We hypothesized that these maternal metabolic pathologies impair cortical visual evoked potentials (cVEPs), a proxy for visual and neuronal maturity.Design: The PREOBE study included 331 pregnant women stratified into four groups; normal weight (controls), overweight, obesity, and GD (the latter including mothers with normal weight, overweight and obesity). In a subsample of the offspring at 3 months (n = 157) and at 18 months (n = 136), we assessed the latencies and amplitudes of the P100 wave from cVEPs and calculated visual acuity.Results: At 3 months of age, visual acuity was significantly poorer in offspring born to GD mothers. At 18 months of age, there were no differences in visual acuity but infants born to GD mothers had significantly longer latencies of cVEPs when measured at 15', and 30' of arc. The group differences at 30' remained significant after confounder adjustment (mean [SD] 121.0 [16.0] vs. 112.6 [7.6] ms in controls, p = 0.007) and the most prolonged latencies were observed in offspring to GD mothers with concurrent overweight (128.9 [26.9] ms, p = 0.002) and obesity (118.5 [5.1] ms, p = 0.020).Conclusions: Infants born to mothers with GD, particularly those with concurrent overweight or obesity, have prolonged latencies of visual evoked potentials at 18 months of age, suggesting that this maternal metabolic profile have a long lasting, non-optimal, effect on infants' brain development.
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| 40. |
- Varenius, Eskil, 1986, et al.
(författare)
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Subarcsecond international LOFAR radio images of Arp 220 at 150 MHz: A kpc-scale star forming disk surrounding nuclei with shocked outflows
- 2016
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 593, s. A86-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Arp 220 is the prototypical ultra luminous infrared galaxy (ULIRG). Despite extensive studies, the structure at MHz-frequencies has remained unknown because of limits in spatial resolution.Aims: This work aims to constrain the flux and shape of radio emission from Arp 220 at MHz frequencies.Methods: We analyse new observations with the International Low Frequency Array (LOFAR) telescope, and archival data from the Multi-Element Radio Linked Interferometer Network (MERLIN) and the Karl G. Jansky Very Large Array (VLA). We model the spatially resolved radio spectrum of Arp 220 from 150 MHz to 33 GHz.Results: We present an image of Arp 220 at 150 MHz with resolution 0.̋65 × 0.̋35, sensitivity 0.15 mJy beam-1, and integrated flux density 394 ± 59 mJy. More than 80% of the detected flux comes from extended (6''≈ 2.2 kpc) steep spectrum (α = -0.7) emission, likely from star formation in the molecular disk surrounding the two nuclei. We find elongated features extending 0.3'' (110 pc) and 0.9'' (330 pc) from the eastern and western nucleus respectively, which we interpret as evidence for outflows. The extent of radio emission requires acceleration of cosmic rays far outside the nuclei. We find that a simple three component model can explain most of the observed radio spectrum of the galaxy. When accounting for absorption at 1.4 GHz, Arp 220 follows the FIR/radio correlation with q = 2.36, and we estimate a star formation rate of 220 M⊙ yr-1. We derive thermal fractions at 1 GHz of less than 1% for the nuclei, which indicates that a major part of the UV-photons are absorbed by dust.Conclusions: International LOFAR observations shows great promise to detect steep spectrum outflows and probe regions of thermal absorption. However, in LIRGs the emission detected at 150 MHz does not necessarily come from the main regions of star formation. This implies that high spatial resolution is crucial for accurate estimates of star formation rates for such galaxies at 150 MHz.
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| 41. |
- Varenius, Eskil, 1986, et al.
(författare)
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Subarcsecond international LOFAR radio images of the M82 nucleus at 118 MHz and 154 MHz
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 574, s. Art. no. A114-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The nuclear starburst in the nearby galaxy M82 provides an excellent laboratory for understanding the physics of star formation. This galaxy has been extensively observed in the past, revealing tens of radio bright compact objects embedded in a diffuse free-free absorbing medium. Our understanding of the structure and physics of this medium in M82 can be greatly improved by high-resolution images at tow frequencies where the effects of free-free absorption are most prominent. Aims. The aims of this study are, firstly, to demonstrate imaging using international baselines of the Low Frequency Array (LOFAR), and secondly, to constrain low frequency spectra of compact and diffuse emission in the central starburst region of M82 via high resolution radio imaging at low frequencies. Methods. The international LOFAR telescope was used to observe M82 at 110-126 MHz and 146-1621\4Hz. Images were obtained using standard techniques from very long baseline interferometry. images were obtained at each frequency range: one only using international baselines, and one only using the longest Dutch (remote) baselines. Results. The 154 MHz image obtained using international baselines is a new imaging record in terms of combined image resolution (0.3") and sensitivity (sigma = 0.15 mIy/beath) at low frequencies (
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| 42. |
- Venkattu, Deepika, et al.
(författare)
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Subarcsecond-resolution Imaging of M51 with the International LOFAR Telescope
- 2023
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 953:2
-
Tidskriftsartikel (refereegranskat)abstract
- We present an International LOFAR Telescope (ILT) subarcsecond-resolution image of the nearby galaxy M51 with a beam size of 0436 × 0366 and rms of 46 μJy. We compare this image with a European VLBI Network study of M51 and discuss the supernovae in this galaxy, which have not yet been probed at these low radio frequencies. We find a flux density of 0.97 mJy for SN 2011dh in the ILT image, which is about five times smaller than the flux density reported by the LOFAR Two-metre Sky Survey (LoTSS) at 6'' resolution using the same data set without the international stations. This difference makes evident the need for LOFAR international baselines to reliably obtain flux density measurements of compact objects in nearby galaxies. Our LOFAR flux density measurement of SN 2011dh directly translates into fitting the radio light curves for the supernova and constraining the mass-loss rates of the progenitor star. We do not detect two other supernovae in the same galaxy, SN 1994I and SN 2005cs, and our observations place limits on the evolution of both supernovae at radio wavelengths. We also discuss the radio emission from the center of M51, in which we detect the active galactic nucleus and other parts of the nuclear emission in the galaxy, with a possible detection of Component N. We discuss a few other sources, including the detection of a high-mass X-ray binary not detected by LoTSS but with a flux density in the ILT image that matches well with higher-frequency catalogs.
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